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class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Alberto Perez" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/6263365/2574513/2990496/s200_alberto.perez.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Alberto Perez</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Alberto" 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class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="6263365" href="https://www.academia.edu/Documents/in/Latin_American_and_Caribbean_History"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/AlbertoPerez7","location":"/AlbertoPerez7","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/AlbertoPerez7","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Latin American and Caribbean History"]}" 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data-dom-id="Pill-react-component-82e32c5f-059b-4514-9a5b-c023e91710c8"></div> <div id="Pill-react-component-82e32c5f-059b-4514-9a5b-c023e91710c8"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Alberto Perez</h3></div><div class="js-work-strip profile--work_container" data-work-id="4835328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age"><img alt="Research paper thumbnail of Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age" class="work-thumbnail" src="https://attachments.academia-assets.com/49609185/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age">Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9ee9bd47f58032a33a45c5248ab5644d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49609185,"asset_id":4835328,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49609185/download_file?st=MTczMjQxOTgwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4835328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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A total of 179 infants (6-12 weeks of age) received three doses of DTPw-HBV vaccine. Blood samples for antibody determinations were taken before vaccination, 2 months after the second dose and I month after the third dose. solicited and unsolicited symptoms were recorded by parents in a diary card. All vaccinees had protective levels of anti-HBs [geometric mean titre (GMT): 1526 mlU ml-'], anti-diphtheria and antitetanus antibodies, I month after the third dose. Ninety-two percent of the subjects exhibited a response to the B. pertussis component. Most (99.4%) solicited reactions occurred within the first 48 h and the majority were mild or moderate. The safety, immunogenicity of this tetruvalent vaccine was demonstrated when it was administered in infunts following the 0, 2, 4-month dosing schedule. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="4835327"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4835327/Refinement_of_the_AMBER_Force_Field_for_Nucleic_Acids_Improving_the_Description_of_%CE%B1_%CE%B3_Conformers"><img alt="Research paper thumbnail of Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of 伪/ 纬 Conformers" class="work-thumbnail" src="https://attachments.academia-assets.com/32123088/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4835327/Refinement_of_the_AMBER_Force_Field_for_Nucleic_Acids_Improving_the_Description_of_%CE%B1_%CE%B3_Conformers">Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of 伪/ 纬 Conformers</a></div><div class="wp-workCard_item"><span>Biophysical Journal</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3aef6b247e4cc180c34cb67cf297b6f2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":32123088,"asset_id":4835327,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/32123088/download_file?st=MTczMjQxOTgwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4835327"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4835327"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4835327; 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The modified force field corrects overpopulations of the a/g 录 (g1,t) backbone that were seen in long (more than 10 ns) simulations with previous AMBER parameter sets (parm94-99). The force field has been derived by fitting to high-level quantum mechanical data and verified by comparison with very high-level quantum mechanical calculations and by a very extensive comparison between simulations and experimental data. The set of validation simulations includes two of the longest trajectories published to date for the DNA duplex (200 ns each) and the largest variety of NA structures studied to date (15 different NA families and 97 individual structures). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="829511" id="papers"><div class="js-work-strip profile--work_container" data-work-id="4835328"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age"><img alt="Research paper thumbnail of Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age" class="work-thumbnail" src="https://attachments.academia-assets.com/49609185/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/4835328/Immune_response_to_a_combined_hepatitis_B_diphtheria_tetanus_and_whole_cell_pertussis_vaccine_administered_to_infants_at_2_4_and_6_months_of_age">Immune response to a combined hepatitis B, diphtheria, tetanus and whole-cell pertussis vaccine administered to infants at 2, 4 and 6 months of age</a></div><div class="wp-workCard_item"><span>Vaccine</span><span>, 1997</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9ee9bd47f58032a33a45c5248ab5644d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":49609185,"asset_id":4835328,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/49609185/download_file?st=MTczMjQxOTgwNCw4LjIyMi4yMDguMTQ2&st=MTczMjQxOTgwNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="4835328"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="4835328"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 4835328; 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A total of 179 infants (6-12 weeks of age) received three doses of DTPw-HBV vaccine. Blood samples for antibody determinations were taken before vaccination, 2 months after the second dose and I month after the third dose. solicited and unsolicited symptoms were recorded by parents in a diary card. All vaccinees had protective levels of anti-HBs [geometric mean titre (GMT): 1526 mlU ml-'], anti-diphtheria and antitetanus antibodies, I month after the third dose. Ninety-two percent of the subjects exhibited a response to the B. pertussis component. Most (99.4%) solicited reactions occurred within the first 48 h and the majority were mild or moderate. The safety, immunogenicity of this tetruvalent vaccine was demonstrated when it was administered in infunts following the 0, 2, 4-month dosing schedule. 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