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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff6dde86a347fe1814dcaa933db7ea64e27db3add-8995x5997.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff6dde86a347fe1814dcaa933db7ea64e27db3add-8995x5997.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff6dde86a347fe1814dcaa933db7ea64e27db3add-8995x5997.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff6dde86a347fe1814dcaa933db7ea64e27db3add-8995x5997.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Ff6dde86a347fe1814dcaa933db7ea64e27db3add-8995x5997.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">November 23rd 2024</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/age-related-disparities-in-long-term-outcomes-for-er-her2-breast-cancer">Age-Related Disparities in Long-Term Outcomes for ER+, HER2– Breast Cancer</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/cameron-santoro"><i>Cameron Santoro</i></a></span></div></div><a href="/view/age-related-disparities-in-long-term-outcomes-for-er-her2-breast-cancer"><a href="/view/age-related-disparities-in-long-term-outcomes-for-er-her2-breast-cancer"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Younger women with estrogen receptor (ER)–positive, HER2-negative breast cancer have significantly worse long-term outcomes, including higher rates of recurrence and metastasis, compared with older women. </p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/racial-inequities-in-guideline-adherent-breast-cancer-care-and-timely-treatment"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F973e75a677d6c10332faffb73fa8e5db35289869-5580x3376.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F973e75a677d6c10332faffb73fa8e5db35289869-5580x3376.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F973e75a677d6c10332faffb73fa8e5db35289869-5580x3376.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F973e75a677d6c10332faffb73fa8e5db35289869-5580x3376.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/racial-inequities-in-guideline-adherent-breast-cancer-care-and-timely-treatment"><span class="text-sm text-gray-500">November 19th 2024</span></a><div><a class="text-[14px]" href="/view/racial-inequities-in-guideline-adherent-breast-cancer-care-and-timely-treatment"><p class="line-clamp-4 text-hidden font-[500]">Racial Inequities in Guideline-Adherent Breast Cancer Care and Timely Treatment</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/cameron-santoro"><i>Cameron Santoro</i></a></span></div></div></div></a><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/breast-cancer-outcomes-improved-in-states-with-medicaid-expansion"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" 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loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/breast-cancer-outcomes-improved-in-states-with-medicaid-expansion"><span class="text-sm text-gray-500">October 24th 2024</span></a><div><a class="text-[14px]" href="/view/breast-cancer-outcomes-improved-in-states-with-medicaid-expansion"><p class="line-clamp-4 text-hidden font-[500]">Breast Cancer Outcomes Improved in States With Medicaid Expansion</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/cameron-santoro"><i>Cameron Santoro</i></a></span></div></div></div></a><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/fda-approves-inavolisib-in-locally-advanced-metastatic-breast-cancer"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span 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class="line-clamp-4 text-hidden font-[500]">FDA Approves Inavolisib in Locally Advanced, Metastatic Breast Cancer</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/julia-bonavitacola"><i>Julia Bonavitacola</i></a></span></div></div></div></a><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/5-things-to-know-before-a-breast-screening"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="lg:object-cover object-contain " 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Updates</h2><p class="line-clamp-5 lg:line-clamp-4 font-light font-rubik text-white text-xs xl:text-sm">Experts discuss the impact of CDK4/G inhibitor use, including medication cost, total care costs, toxicity profiles, and strategies to manage and optimize patient outcomes in high-risk early breast cancer. </p><div style="color:var(--primary)"><a class="font-bold font-rubik text-xs flex items-center gap-2 mt-2.5 xs:mt-4 lg:mt-2.5 xl:mt-3.5 py-2 px-3 cursor-pointer max-w-fit bg-white hover:bg-gray-300 rounded-md" href="https://bit.ly/3XNNok1">Visit Now</a></div></div><div class="w-full max-h-[385px] lg:max-h-[243px] xl:max-h-[311px] overflow-hidden flex justify-center items-center rounded-br-none rounded-tr-md rounded-tl-md lg:rounded-r-md lg:rounded-tl-none pointer-events-none"><span style="box-sizing:border-box;display:inline-block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:relative;max-width:100%"><span 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id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/advancing-breast-cancer-care-with-her2-targeted-therapies"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f759b41e0a4142705c22cad2a695f63b5510bf59-1200x675.jpg?fit=crop&auto=format" alt="Michael Hassett, MD, MPH, Dana-Farber Cancer Institute" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/advancing-breast-cancer-care-with-her2-targeted-therapies">Advancing Breast Cancer Care With HER2-Targeted Therapies</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/advancing-breast-cancer-care-with-her2-targeted-therapies"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In this interview from our Institute for Value-Based Medicine® event in Boston, we speak with Michael Hassett, MD, MPH, Dana-Farber Cancer Institute, on the clinical significance and cost implications of HER2 in the breast cancer space.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/managing-germline-mutations-in-hereditary-breast-cancer-risk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/32ec24199c9fc74174402cb493dd846dcef6cfc8-6000x3600.jpg?fit=crop&auto=format" alt="Breastcancergeneticrisk | Image Credit: © Rasi-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/managing-germline-mutations-in-hereditary-breast-cancer-risk">Managing Germline Mutations in Hereditary Breast Cancer Risk</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/managing-germline-mutations-in-hereditary-breast-cancer-risk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Hereditary breast cancers are caused by germline mutations, which are genetic mutations inherited at conception and so called because they originate in germ cells, those that develop into reproductive cells and become eggs in female individuals and sperm in male individuals.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/acs-2024-report-shows-breast-cancer-equity-gap"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6c1a7f226de39f74c13f4eaa2febaa6281af83c9-5731x3826.jpg?fit=crop&auto=format" alt="Breast cancer support group | Image Credit: Atstock Productions - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/acs-2024-report-shows-breast-cancer-equity-gap">ACS 2024 Report Shows Breast Cancer Equity Gap</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/acs-2024-report-shows-breast-cancer-equity-gap"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The American Cancer Society (ACS) 2024 report emphasizes significant racial disparities in breast cancer outcomes and calls for increased efforts to improve equity in screening and treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/celebrating-world-dense-breast-day-raising-awareness-and-advocacy-of-dense-breasts"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3f6cbca2a7387c9f753833683d5ada1120c058fa-4000x2661.jpg?fit=crop&auto=format" alt="Breast ultrasound | Image Credit: Василь Івасюк - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/celebrating-world-dense-breast-day-raising-awareness-and-advocacy-of-dense-breasts">Celebrating World Dense Breast Day: Raising Awareness and Advocacy of Dense Breasts</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/celebrating-world-dense-breast-day-raising-awareness-and-advocacy-of-dense-breasts"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">World Dense Breast Day emphasizes the need for awareness and advocacy for individuals with dense breasts, which can negatively impact mammogram results and increase breast cancer risk.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ribociclib-for-early-breast-cancer-treatment-with-high-recurrence-rate"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/479562cf75024b96c9055ce170fc5ee092146c83-6960x4640.jpg?fit=crop&auto=format" alt="FDA approval. | Image Credit: Tada Images - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ribociclib-for-early-breast-cancer-treatment-with-high-recurrence-rate">FDA Approves Ribociclib for Early Breast Cancer Treatment With High Recurrence Rate</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-ribociclib-for-early-breast-cancer-treatment-with-high-recurrence-rate"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved ribociclib (Kisqali) for adjuvant treatment of high-risk, hormone receptor-positive, HER2-negative early breast cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/addressing-disparities-in-long-term-survivorship-and-quality-of-life-for-young-patients-with-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/98b2b127ba91a01b820b60faf5eb82544b95d755-5000x3337.jpg?fit=crop&auto=format" alt="Addressing Disparities in Long-Term Survivorship and Quality of Life for Young Patients With Breast Cancer " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/addressing-disparities-in-long-term-survivorship-and-quality-of-life-for-young-patients-with-breast-cancer">Addressing Disparities in Long-Term Survivorship and Quality of Life for Young Patients With Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/alana-hippensteele">Alana Hippensteele</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/addressing-disparities-in-long-term-survivorship-and-quality-of-life-for-young-patients-with-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Disparities continue in younger patients, raising the need for novel interventions to mitigate challenges associated with younger age at diagnosis.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breast-density-disclosure-now-mandated-for-mammograms"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/acdec6c75b61f432c0b6a36a178616b5586ae59a-5120x2880.jpg?fit=crop&auto=format" alt="Mammogram screening. | Image Credit: Gorodenkoff - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breast-density-disclosure-now-mandated-for-mammograms">Breast Density Disclosure Now Mandated for Mammograms</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breast-density-disclosure-now-mandated-for-mammograms"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Mammography facilities are now nationally required to inform patients about their breast density, which can affect cancer detection.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-enhanced-breast-cancer-screening-economically-viable-in-the-uk"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aabbf38d2c99291f06112b17174587a6f877b690-5523x3675.jpg?fit=crop&auto=format" alt="Health care costs and fees. | Image Credit: Nuttapong punna - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-enhanced-breast-cancer-screening-economically-viable-in-the-uk">AI-Enhanced Breast Cancer Screening Economically Viable in the UK</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-enhanced-breast-cancer-screening-economically-viable-in-the-uk"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Using artificial intelligence (AI) in breast cancer screenings in the United Kingdom could be cost-effective and improve health outcomes after identifying more cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/narrowing-the-focus-to-address-care-disparities-dr-demetria-smith-graziani"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/112dcda2c154a98b9ac511d95539c510b5697af1-1200x640.png?fit=crop&auto=format" alt="Demetria Smith-Graziani, MD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/narrowing-the-focus-to-address-care-disparities-dr-demetria-smith-graziani">Narrowing the Focus to Address Care Disparities: Dr Demetria Smith-Graziani</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/narrowing-the-focus-to-address-care-disparities-dr-demetria-smith-graziani"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While it can seem overwhelming or difficult to decide where to start addressing racial and ethnic disparities in health care, the key is to focus on a manageable area that can be built upon.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/systemic-inequities-in-global-breast-cancer-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef69d9652a7be5d00035f595ad2e119fcd5afaeb-5599x3958.jpg?fit=crop&auto=format" alt="Global breast cancer map. | Image Credit: vectorfusionart - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/systemic-inequities-in-global-breast-cancer-care">Systemic Inequities in Global Breast Cancer Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/systemic-inequities-in-global-breast-cancer-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A new review highlights the urgent need for research-driven solutions in breast cancer to enhance early detection, treatment, and patient support across diverse populations. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/biological-and-structural-factors-fuel-racial-disparities-in-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/112dcda2c154a98b9ac511d95539c510b5697af1-1200x640.png?fit=crop&auto=format" alt="AJMC Q&A With Demetria Smith-Graziani, MD, MPH | Photo credit: Emory Winship Cancer Institute" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/biological-and-structural-factors-fuel-racial-disparities-in-breast-cancer">Biological and Structural Factors Fuel Racial Disparities in Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/biological-and-structural-factors-fuel-racial-disparities-in-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Demetria Smith-Graziani, MD, MPH, Emory University School of Medicine, explained biological and structural obstacles to equitable breast cancer outcomes and care across racial and ethnic groups. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-improves-breast-cancer-detection-but-requires-careful-monitoring"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a60d6234f3e07d105e7448610665edf62fc579ea-6240x2479.jpg?fit=crop&auto=format" alt="Researchers collaborate. | Image Credit: wichayada - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-improves-breast-cancer-detection-but-requires-careful-monitoring">AI Improves Breast Cancer Detection but Requires Careful Monitoring</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-improves-breast-cancer-detection-but-requires-careful-monitoring"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Artificial intelligence (AI) can aid in breast cancer detection, but radiologists need training to ensure accuracy and prevent missed cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/covid-19-disrupted-breast-cancer-screenings-exacerbated-disparities"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4c9ead5e20cbc18be88e575296fb89dfc6867bbb-5000x3000.jpg?fit=crop&auto=format" alt="Medical mammogram exam | Image Credit: TeraVector - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-disrupted-breast-cancer-screenings-exacerbated-disparities">COVID-19 Disrupted Breast Cancer Screenings, Exacerbated Disparities</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/covid-19-disrupted-breast-cancer-screenings-exacerbated-disparities"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The COVID-19 pandemic disrupted breast cancer screenings, leading to decreased follow-up rates and widening health disparities.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/black-women-with-obesity-elevated-leptin-levels-at-higher-risk-for-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ee4083fbdaed5bb77b56a9fe7bf8191189623c1f-9504x6336.jpg?fit=crop&auto=format" alt="Pink ribbon for breast cancer. | Image Credit: Andrey Popov - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 31st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/black-women-with-obesity-elevated-leptin-levels-at-higher-risk-for-breast-cancer">Black Women With Obesity, Elevated Leptin Levels at Higher Risk for Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/black-women-with-obesity-elevated-leptin-levels-at-higher-risk-for-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The risk of early-onset breast cancer, particularly luminal A and triple-negative subtypes, was higher in Black women with obesity and high leptin levels compared with White women. This research highlights the urgent need for targeted interventions to address racial disparities in breast cancer outcomes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dose-modifications-patient-adherence-strategies-for-managing-toxicities-cdk-4-6-inhibitors"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6965a7e6cd60020344e97d679724e3b57879419b-1048x592.png?fit=crop&auto=format" alt="A panel of 4 experts on breast cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dose-modifications-patient-adherence-strategies-for-managing-toxicities-cdk-4-6-inhibitors">Dose Modifications & Patient Adherence Strategies for Managing Toxicities CDK 4/6 Inhibitors</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollos-s-hanna-pharmd-bcps-bcop">Kirollos S. Hanna, PharmD, BCPS, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hope-rugo-md">Hope Rugo, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joyce-o-shaughnessy-md">Joyce O’Shaughnessy, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/naomi-dempsey-md">Naomi Dempsey, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dose-modifications-patient-adherence-strategies-for-managing-toxicities-cdk-4-6-inhibitors"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A panel of experts discuss the variables of dosage and patient adherence in regards to managing toxicities from CDK4/6 inhibitors.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-o-shaughnessy-shares-her-management-strategy-for-hematologic-toxicities-with-ribociclib"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6965a7e6cd60020344e97d679724e3b57879419b-1048x592.png?fit=crop&auto=format" alt="A panel of 4 experts on breast cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-o-shaughnessy-shares-her-management-strategy-for-hematologic-toxicities-with-ribociclib">Dr. O’Shaughnessy Shares Her Management Strategy for Hematologic Toxicities with Ribociclib</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollos-s-hanna-pharmd-bcps-bcop">Kirollos S. Hanna, PharmD, BCPS, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hope-rugo-md">Hope Rugo, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joyce-o-shaughnessy-md">Joyce O’Shaughnessy, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/naomi-dempsey-md">Naomi Dempsey, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-o-shaughnessy-shares-her-management-strategy-for-hematologic-toxicities-with-ribociclib"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A medical expert navigates toxicity management in patients being treated with ribociclib.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/hope-rugo-md-shares-her-management-strategy-for-gi-toxicities-with-abema"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6965a7e6cd60020344e97d679724e3b57879419b-1048x592.png?fit=crop&auto=format" alt="A panel of 4 experts on breast cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/hope-rugo-md-shares-her-management-strategy-for-gi-toxicities-with-abema">Hope Rugo, MD Shares Her Management Strategy for GI Toxicities with Abema</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollos-s-hanna-pharmd-bcps-bcop">Kirollos S. Hanna, PharmD, BCPS, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hope-rugo-md">Hope Rugo, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joyce-o-shaughnessy-md">Joyce O’Shaughnessy, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/naomi-dempsey-md">Naomi Dempsey, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/hope-rugo-md-shares-her-management-strategy-for-gi-toxicities-with-abema"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Dr. Rugo details her management strategy in regards to GI toxicities.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-breast-cancer-immunotherapy-trials-make-modest-clinical-impact"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e7fdf62a3eba5b90514d56dd75262e68f0ccabac-5760x3840.jpg?fit=crop&auto=format" alt="Female patient holding up breast cancer awareness ribbon | Image Credit: Pixel-Shot - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-breast-cancer-immunotherapy-trials-make-modest-clinical-impact">Study: Breast Cancer Immunotherapy Trials Make Modest Clinical Impact</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/brooke-mccormick">Brooke McCormick</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-breast-cancer-immunotherapy-trials-make-modest-clinical-impact"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite numerous trials, breast cancer immunotherapies have had a modest clinical impact, with only 2 approved drugs, highlighting inefficiencies in the clinical trial system.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/risks-benefits-of-bilateral-mastectomy-for-unilateral-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7632a412f95244f825b118f7de18a59e0da1a2b6-4023x2682.jpg?fit=crop&auto=format" alt="Mammogram screening | Image Credit: okrasiuk - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/risks-benefits-of-bilateral-mastectomy-for-unilateral-breast-cancer">Risks, Benefits of Bilateral Mastectomy for Unilateral Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/risks-benefits-of-bilateral-mastectomy-for-unilateral-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Despite a significant increase in women with unilateral breast cancer who received a bilateral mastectomy, this study found no survival benefit compared with other treatment options. Although removing the unaffected breast reduces the risk of developing cancer in the other breast, results did not show decreased risk of death from breast cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/hormone-therapy-may-reduce-dementia-risk-in-patients-with-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6216d8b25f653b6e76813ac771ad25e10e33f594-5145x2915.jpg?fit=crop&auto=format" alt="Oncologist examines brain. | Image Credit: Liubomyr - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 18th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/hormone-therapy-may-reduce-dementia-risk-in-patients-with-breast-cancer">Hormone Therapy May Reduce Dementia Risk in Patients With Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/hormone-therapy-may-reduce-dementia-risk-in-patients-with-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Study results suggest hormone therapy after breast cancer may lower dementia risk, particularly for younger Black women, but further research is needed to confirm these findings.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/lower-utilization-seen-for-patients-with-breast-cancer-using-remote-monitoring-with-texts"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b1ac13a9694f079f8cee9a1a1b58aa1b1e579a3b-5739x3826.jpg?fit=crop&auto=format" alt="Patient with breast cancer using mobile app to track symptoms. | Image Credit: Rakchanok - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/lower-utilization-seen-for-patients-with-breast-cancer-using-remote-monitoring-with-texts">Lower Utilization Seen for Patients With Breast Cancer Using Remote Monitoring With Texts</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/lower-utilization-seen-for-patients-with-breast-cancer-using-remote-monitoring-with-texts"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A remote monitoring app with alerts for doctors did not improve medication adherence in patients with breast cancer, but those receiving tailored text messages on top of monitoring saw reduced high-cost health care use.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/brca-genes-in-breast-cancer-balancing-risk-treatment-with-breast-conservation-therapy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9a51ecfc7952665526fce33dc0c00d0554da777c-5184x3888.jpg?fit=crop&auto=format" alt="BRCA mutation genetic testing. | Image Credit: Yurii Kibalnik - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/brca-genes-in-breast-cancer-balancing-risk-treatment-with-breast-conservation-therapy">BRCA Genes in Breast Cancer: Balancing Risk, Treatment With Breast-Conservation Therapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/brca-genes-in-breast-cancer-balancing-risk-treatment-with-breast-conservation-therapy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Breast-conserving therapy for BRCA1/2 mutation carriers has higher risks of future breast cancers than the general population, but most patients avoid another cancer event, and many remain bilateral mastectomy–free after 20 years.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-dempsey-shares-how-the-type-of-endocrine-therapy-can-impact-toxicities-seen-in-her-patients"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6965a7e6cd60020344e97d679724e3b57879419b-1048x592.png?fit=crop&auto=format" alt="A panel of 4 experts on breast cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-dempsey-shares-how-the-type-of-endocrine-therapy-can-impact-toxicities-seen-in-her-patients">Dr Dempsey Shares How the Type of Endocrine Therapy Can Impact Toxicities Seen in Her Patients</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollos-s-hanna-pharmd-bcps-bcop">Kirollos S. Hanna, PharmD, BCPS, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hope-rugo-md">Hope Rugo, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joyce-o-shaughnessy-md">Joyce O’Shaughnessy, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/naomi-dempsey-md">Naomi Dempsey, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-dempsey-shares-how-the-type-of-endocrine-therapy-can-impact-toxicities-seen-in-her-patients"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Dr. Dempsey details how different types of endocrine therapies have impacted toxicities within her patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/primary-differences-in-the-toxicity-profiles-of-abemaciclib-and-ribociclib"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6965a7e6cd60020344e97d679724e3b57879419b-1048x592.png?fit=crop&auto=format" alt="A panel of 4 experts on breast cancer" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/primary-differences-in-the-toxicity-profiles-of-abemaciclib-and-ribociclib">Primary Differences in the Toxicity Profiles of Abemaciclib and Ribociclib</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kirollos-s-hanna-pharmd-bcps-bcop">Kirollos S. Hanna, PharmD, BCPS, BCOP</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hope-rugo-md">Hope Rugo, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joyce-o-shaughnessy-md">Joyce O’Shaughnessy, MD</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/naomi-dempsey-md">Naomi Dempsey, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/primary-differences-in-the-toxicity-profiles-of-abemaciclib-and-ribociclib"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A panel of experts compare the toxicity profiles of abemaciclib and ribociclib.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/blu-222-shows-safety-tolerability-in-combination-therapy-for-patients-with-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9fb5b784d1fe5baee7f4b6916f89a8e68ffb7a39-5416x3611.jpg?fit=crop&auto=format" alt="Doctor and patient with breast cancer. | Image Credit: Pixel-Shot - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/blu-222-shows-safety-tolerability-in-combination-therapy-for-patients-with-breast-cancer">BLU-222 Shows Safety, Tolerability in Combination Therapy for Patients With Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/blu-222-shows-safety-tolerability-in-combination-therapy-for-patients-with-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Early data suggest that BLU-222 combined with ribociclib and fulvestrant is safe and tolerable for patients with HR-positive and HER2-negative breast cancer, potentially overcoming resistance to CDK4/6 inhibitors.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/sh-105-gains-fda-approval-for-breast-ovarian-cancers"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3deabc81aa93f0e49190012e256a274872b958e8-4363x3438.jpg?fit=crop&auto=format" alt="FDA approval | Image Credit: BHM - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/sh-105-gains-fda-approval-for-breast-ovarian-cancers">SH-105 Gains FDA Approval for Breast, Ovarian Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/sh-105-gains-fda-approval-for-breast-ovarian-cancers"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved SH-105 (Tepylute) prediluted injectable treatment for breast and ovarian cancers. This innovative formulation eliminates the need for complex powder reconstitution, improving safety and patient care.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/t-dm1-shows-promise-with-low-recurrence-rates-in-her2-positive-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4158092685ca6a612fa66d12ec1e2c8775b0fa95-4738x3166.jpg?fit=crop&auto=format" alt="Patients with HER2-positive breast cancer showed benefit with T-DM1 treatment. | Image Credit- Marina - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/t-dm1-shows-promise-with-low-recurrence-rates-in-her2-positive-breast-cancer">T-DM1 Shows Promise With Low Recurrence Rates in HER2-Positive Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/t-dm1-shows-promise-with-low-recurrence-rates-in-her2-positive-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with stage I HER2-positive breast cancer treated with rastuzumab emtansine (T-DM1) had beneficial long-term outcomes with a 5-year disease-free survival rate of 97%, with the HER2DX score potentially identifying those at higher risk of recurrence.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-reduced-by-bariatric-surgery-in-patients-with-high-insulin-levels"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a4efc5d9b20db081b50c2842a8449f4b2f25d744-4743x3162.jpg?fit=crop&auto=format" alt="Breast cancer ribbon. | Image Credit: Visual Generation - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-reduced-by-bariatric-surgery-in-patients-with-high-insulin-levels">Breast Cancer Risk Reduced by Bariatric Surgery in Patients With High Insulin Levels</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-reduced-by-bariatric-surgery-in-patients-with-high-insulin-levels"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A Swedish study suggests bariatric surgery may lower breast cancer risk in obese women, particularly those with high insulin levels at baseline. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-management-in-transgender-men-after-chest-contouring-surgery"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/550bbdf1dcc2621fbf262858a948c83be7ffd663-5823x4090.jpg?fit=crop&auto=format" alt="Group of people holding bc ribbon | Image Credit/ Rawpixel.com - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-management-in-transgender-men-after-chest-contouring-surgery">Breast Cancer Risk Management in Transgender Men After Chest Contouring Surgery</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breast-cancer-risk-management-in-transgender-men-after-chest-contouring-surgery"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This study highlights the lack of clear guidelines for breast cancer management in transgender men after chest contouring surgery. While data is limited, the authors suggest adapting existing recommendations for cisgender women and implementing risk management strategies like pre-surgery evaluation and education.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/neighborhood-deprivation-linked-to-increased-breast-cancer-deaths-for-white-women-but-not-black-women"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3e80bd9ee8d050b4fa27a61194021b815d34c09c-5376x3584.jpg?fit=crop&auto=format" alt="Black woman doctor | Image Credit | mihail - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/neighborhood-deprivation-linked-to-increased-breast-cancer-deaths-for-white-women-but-not-black-women">Neighborhood Deprivation Linked to Increased Breast Cancer Deaths for White Women, but Not Black Women</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/neighborhood-deprivation-linked-to-increased-breast-cancer-deaths-for-white-women-but-not-black-women"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A recent study found that neighborhood deprivation is associated with higher breast cancer death rates for non-Hispanic White women, but not Black women. This suggests factors beyond socioeconomic status contribute to the racial disparity.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/breast-cancer?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=6">6</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=7">7</a><a class="px-4 py-2 border-y border-r " href="/compendium/breast-cancer?page=8">8</a><div class="px-4 py-2 border-y 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","published":"2024-08-21T13:28:48.767Z","updatedOn":null,"contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles"},"authors":[{"displayName":"Cameron Santoro","url":"cameron-santoro"}],"title":"Systemic Inequities in Global Breast Cancer Care","url":"systemic-inequities-in-global-breast-cancer-care","thumbnail":{"alt":"Global breast cancer map. | Image Credit: vectorfusionart - stock.adobe.com","caption":"A new review highlights the urgent need for research-driven solutions in breast cancer to enhance early detection, treatment, and patient support across diverse populations. | Image Credit: vectorfusionart - stock.adobe.com","asset":{"_ref":"image-ef69d9652a7be5d00035f595ad2e119fcd5afaeb-5599x3958-jpg","_type":"reference"},"_type":"mainImage"},"_id":"01ae1396-089d-41e4-b42d-d8867dbbd44c","factCheckAuthors":null},{"contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"authors":[{"displayName":"Rose McNulty","url":"rose-mcnulty"}],"_id":"c97cd9d2-40cf-4db2-aa8e-a53f2cc9a2b8","url":"biological-and-structural-factors-fuel-racial-disparities-in-breast-cancer","thumbnail":{"_type":"mainImage","alt":"AJMC Q\u0026A With Demetria Smith-Graziani, MD, MPH | Photo credit: Emory Winship Cancer Institute","caption":"AJMC Q\u0026A With Demetria Smith-Graziani, MD, MPH | Photo credit: Emory Winship Cancer Institute","asset":{"_ref":"image-112dcda2c154a98b9ac511d95539c510b5697af1-1200x640-png","_type":"reference"}},"published":"2024-08-19T19:32:21.309Z","title":"Biological and Structural Factors Fuel Racial Disparities in Breast Cancer","summary":"Demetria Smith-Graziani, MD, MPH, Emory University School of Medicine, explained biological and structural obstacles to equitable breast cancer outcomes and care across racial and ethnic groups. 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Wei spoke with ","_key":"9e8a44e4ea8c0","_type":"span","marks":[]},{"marks":["em"],"text":"The American Journal of Managed Care","_key":"3f0446395c24","_type":"span"},{"_type":"span","marks":["em","superscript"],"text":"®","_key":"92e06912eb1f"},{"_type":"span","marks":[],"text":" at the Denver Regional Institute for Value-Based Medicine","_key":"b7d68321460f"},{"_type":"span","marks":["superscript"],"text":"®","_key":"1d0ed4d909ba"},{"_type":"span","marks":[],"text":" event, where she participated in a session on new treatments for HR+/HER2– breast cancer.\n","_key":"0ee88014057c"}],"_type":"block","style":"normal","_key":"f32cfb9f19dd","markDefs":[]},{"style":"normal","_key":"77925eb4f590","markDefs":[],"children":[{"marks":[],"text":"She emphasized emerging research, such as the promising role of targeting specific mutations like ","_key":"18bb4a69a8670","_type":"span"},{"marks":["em"],"text":"PIK3CA","_key":"c76ee7678dbb","_type":"span"},{"marks":[],"text":" and ","_key":"177f79d39063","_type":"span"},{"marks":["em"],"text":"ESR1","_key":"63fbdb99ae78","_type":"span"},{"_type":"span","marks":[],"text":". Genomic profiling is increasingly being utilized to identify patients who may benefit from these targeted therapies, although its adoption in the first-line setting for metastatic breast cancer remains under discussion. Overall, the field of HR+/HER2– breast cancer is witnessing groundbreaking developments, with a focus on personalized medicine and targeted therapies to improve patient outcomes.","_key":"60008dac3118"}],"_type":"block"},{"style":"normal","_key":"387f4f8b9894","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"","_key":"4a8296567e89"}],"_type":"block"},{"markDefs":[],"children":[{"text":"This transcript was lightly edited for clarity.","_key":"bddeec4e6af10","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":"\n","_key":"4a447c17bbe00"}],"_type":"block","style":"normal","_key":"2624ba867767"},{"style":"normal","_key":"3ecc5b565ae5","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"97bfb85aecef0"}],"_type":"block"},{"_type":"block","style":"normal","_key":"ad1c334a15a7","markDefs":[],"children":[{"_key":"2f3031d67711","_type":"span","marks":["strong","underline"],"text":""}]},{"_key":"45ce56ac71be","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are the most promising areas of research currently exploring new therapeutic targets or approaches for HR+/HER2- breast cancer?","_key":"a4db24f1afd50"}],"_type":"block","style":"normal"},{"style":"normal","_key":"309a3c3397de","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"96fa94c60ee60"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"There's many exciting research [studies] going on. For the nonmetastatic setting, I think we are exploring more treatment options in addition to the traditional tamoxifen and aromatase inhibitors that try to improve the outcome and decrease the cancer recurrence risk.","_key":"d4a152bc93690"}],"_type":"block","style":"normal","_key":"536c97e70ff5","markDefs":[]},{"markDefs":[],"children":[{"text":"","_key":"b065719ed9ed0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"d61a2bf553b8"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"For example, the recently FDA-approved ribociclib is 1 of the drugs. A couple years ago, adjuvant abemaciclib was also approved for this purpose as well. Both are used in the adjuvant setting.","_key":"8e592ebc583f0"}],"_type":"block","style":"normal","_key":"7ce7f7d4ce66"},{"children":[{"_type":"span","marks":[],"text":"","_key":"720b91eca3f80"}],"_type":"block","style":"normal","_key":"8f92f1c29d31","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the metastatic setting, there's also many exciting developments as well. We have this ","_key":"e88fced2165f0"},{"marks":["em"],"text":"PIK3CA","_key":"d9bce5aaa0f8","_type":"span"},{"marks":[],"text":" mutation, and then many companies are trying to develop inhibitors to target that. Also, we have this ","_key":"5ab5607fff04","_type":"span"},{"_type":"span","marks":["em"],"text":"ESR1","_key":"83a939c02a5c"},{"text":" mutation, and we do have a medication that can target that at this moment.","_key":"d48846c3fcd3","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"b65e32cda962"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"4b11e561086d0","_type":"span"}],"_type":"block","style":"normal","_key":"1b8e3798f1d4"},{"_key":"716ce595982e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"There is also this concept of, \"What if the patient has both ","_key":"deda3a582e640"},{"marks":["em"],"text":"PIK3CA","_key":"d389271108b8","_type":"span"},{"marks":[],"text":" mutation and ","_key":"03ef56b7d6ff","_type":"span"},{"text":"ESR1","_key":"080dea9c9a8f","_type":"span","marks":["em"]},{"_key":"af152ab33e8d","_type":"span","marks":[],"text":" mutation? Should we use a combo-targeted mutation?\" Those are some of the very exciting fields the research is currently focused on as well."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"552e67298ccf0"}],"_type":"block","style":"normal","_key":"e98e782927bb"},{"children":[{"_type":"span","marks":["strong"],"text":"How is genomic profiling being used to tailor treatment plans for patients with HR+/HER2- breast cancer?","_key":"fffd63d291a20"}],"_type":"block","style":"normal","_key":"43060ec04978","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"c7f8f1e21f2a0"}],"_type":"block","style":"normal","_key":"a2b3ff4e9704","markDefs":[]},{"style":"normal","_key":"3ab37f086993","markDefs":[],"children":[{"_key":"44e9240c18fa0","_type":"span","marks":[],"text":"That's a very good question. I think historically we are running very behind compared with our peers. For example for lung cancer, they will check the EGFR at the time when the patient was diagnosed with metastatic disease."}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"","_key":"4507614828e20"}],"_type":"block","style":"normal","_key":"b7adc360bcf0","markDefs":[]},{"_key":"8d2ca8fda65a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, because historically we don't have all of these actionable mutations, we don't have the drugs that can target those mutations, we are way behind compared with our peers. We don't check NGS [next-generation sequencing], but now because we have this medication that can target PIK3CA mutation, and also we have medication that specifically benefits a patient with ESR1 mutation, so we start to check the patient with more genomic testing with NGS and the circulating tumor DNA.","_key":"92d05a7ef9a00"}],"_type":"block","style":"normal"},{"style":"normal","_key":"4027c332d21e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"71edbbe2b8410"}],"_type":"block"},{"style":"normal","_key":"2ec4e1cb3b5c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Now the thing is, because the PIK3CA inhibitor is approved for second line and also the elacestrant target ESR1 is also approved for the second line. Most of the time we still feel that's not much value to check the NGS when the patient was diagnosed with metastatic breast cancer because the result does not really change how we treat the patient in the first line. 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She emphasized the need for biomarkers to identify patients who could benefit from more aggressive therapies, such as triplet therapy. She also discussed the promising potential of selective estrogen receptor degraders (SERDs), which may replace aromatase inhibitors as the standard of care due to their superior efficacy and reduced side effects.","_key":"3df55b7eec162","_type":"span"}],"_type":"block","style":"normal","_key":"8c14608d2a15"},{"children":[{"_key":"ca57627aedb6","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"7ae221f77943","markDefs":[]},{"_key":"720a75177db5","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript was lightly edited for clarity.","_key":"0680d733074a0"}],"_type":"block","style":"normal"},{"_key":"88b988e3a04b","markDefs":[],"children":[{"_key":"189dd60054cc","_type":"span","marks":["em"],"text":""}],"_type":"block","style":"normal"},{"style":"normal","_key":"598ad4066b01","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"5842a52687740"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"455a1820fbd7","_type":"span","marks":["strong","underline"],"text":""}],"_type":"block","style":"normal","_key":"f5580236957b"},{"markDefs":[],"children":[{"text":"How are researchers addressing the challenges of drug resistance and recurrence in HR+/HER2- breast cancer?","_key":"23f59ad9b77f0","_type":"span","marks":["strong"]},{"_type":"span","marks":[],"text":"\n","_key":"14fd722cf57f0"}],"_type":"block","style":"normal","_key":"2d06ebbdcf1d"},{"_key":"71a5d08689ab","markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/fda-approves-inavolisib-in-locally-advanced-metastatic-breast-cancer","_key":"4b1f5b12da88","blank":true}],"children":[{"_type":"span","marks":[],"text":"With the ","_key":"f4758d3ad69c0"},{"_type":"span","marks":["4b1f5b12da88"],"text":"inavolisib approval","_key":"f4758d3ad69c1"},{"_type":"span","marks":[],"text":", there's the concept that, obviously, many patients are, in fact, endocrine-resistant and will become endocrine-resistant. This is not likely early on in the course of their treatment, but likely somewhere around years 5 through 10 or beyond. These are patients who metastasize and are resistant to an aromatase inhibitor.","_key":"f4758d3ad69c2"}],"_type":"block","style":"normal"},{"_key":"7831442b55a7","markDefs":[],"children":[{"text":"","_key":"390e497e25170","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"cebc231237fa","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://medlineplus.gov/genetics/gene/pik3ca/","_key":"8150e1d3cd47"}],"children":[{"_type":"span","marks":[],"text":"I think that being forward thinkers and thinking ahead of the menu of choices we already have and using biomarkers like this trial did. The ","_key":"44e3658316ff0"},{"marks":["8150e1d3cd47"],"text":"PIK3CA","_key":"44e3658316ff1","_type":"span"},{"_type":"span","marks":[],"text":" patients that progress on aromatase inhibitors within a year are the patients that are going to get a triplet therapy, so escalate therapy in those [patients] who are truly endocrine resistant.","_key":"44e3658316ff2"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"0e3b1f2db2680","_type":"span"}],"_type":"block","style":"normal","_key":"018f3a98424f"},{"_type":"block","style":"normal","_key":"877ba8185f11","markDefs":[],"children":[{"_type":"span","marks":[],"text":"There are a lot of challenges in sequencing that still remain today that I think are not answered. I think we have a lot of choices out but then we're left with \"How do we choose one agent over another?\" I think that speaks to the testament of how quickly the FDA is approving these agents, the clinical trials, and how robust they have been, but that leaves us in the clinic with challenges. I think biomarkers probably would be my conclusion statement on how to do a better job with resistance.","_key":"0a8ee1340b9d0"}]},{"_type":"block","style":"normal","_key":"2ae16d96ecc7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e56c8f9b41370"}]},{"markDefs":[],"children":[{"text":"In your opinion, what are the most exciting areas of research that may lead to significant breakthroughs in the treatment of HR+/HER2- breast cancer in the next decade?","_key":"09ee36fe776a0","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"42f01ef033bf"},{"markDefs":[],"children":[{"text":"","_key":"a90cb3d8d9cd0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"431b40871dbf"},{"_type":"block","style":"normal","_key":"a408d60c044e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We have a variety of menus in our current treatment options with the oral SERDs, selective estrogen receptor degraders. I tell my patients this; we've made it known that SERDs are superior to our most potent injection, which is faslodex [fulvestrant] in the metastatic setting. There's no reason to believe that SERDS are not going to be more effective than an aromatase inhibitor.","_key":"88acd30695a60"}]},{"_type":"block","style":"normal","_key":"904c0b035270","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4fa5a4d767fe0"}]},{"style":"normal","_key":"7199c7efdae9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"If we look at just the trajectory of how tamoxifen beat aromatase inhibitors, now we have this new wave of options. 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She highlights how checkpoint inhibitors like pembrolizumab have shown efficacy in specific settings, while managing immune-related adverse events.\n","_key":"11c5bd452adf"}],"_type":"block"},{"_key":"f0e93b717b40","markDefs":[],"children":[{"_key":"4167e819d0050","_type":"span","marks":["em"],"text":"This transcript was lightly edited for clarity."}],"_type":"block","style":"normal"},{"_key":"0ed0ae65644e","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"","_key":"d23b6e51eb72"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"44f0bec8489e0"},{"_type":"span","marks":[],"text":"\n","_key":"bf68f660db600"}],"_type":"block","style":"normal","_key":"efbb3a4277e8","markDefs":[]},{"markDefs":[],"children":[{"_key":"2cea3e2edac90","_type":"span","marks":["strong"],"text":"How are new treatments impacting patient outcomes, and what are the long-term implications?"}],"_type":"block","style":"normal","_key":"60f8a6add993"},{"children":[{"_type":"span","marks":[],"text":"","_key":"3ffb6dbdb0bc0"}],"_type":"block","style":"normal","_key":"3861d8f896a2","markDefs":[]},{"_type":"block","style":"normal","_key":"ef199995a5da","markDefs":[],"children":[{"_key":"11850fdcf8010","_type":"span","marks":[],"text":"This is very exciting because the ADCs, all of the targeted therapies, I think significantly improve the outcome."}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"1ca98296a7880"}],"_type":"block","style":"normal","_key":"6e940f85392d"},{"_type":"block","style":"normal","_key":"419fe86f2c13","markDefs":[],"children":[{"marks":[],"text":"Historically, in the metastatic setting, before the CDK4/6 inhibitor was approved, patients had a much shorter overall survival. However, now with the CDK4/6 inhibitor, the overall survival among all the CDK4/6 inhibitors is about 50 to 60 months, that's about 5 to 6 years on average.","_key":"ff7828a6214b0","_type":"span"}]},{"_type":"block","style":"normal","_key":"01070d5d445a","markDefs":[],"children":[{"marks":[],"text":"","_key":"3999e820fa930","_type":"span"}]},{"style":"normal","_key":"bd93456a0996","markDefs":[],"children":[{"_type":"span","marks":[],"text":"After that, a patient can use ADCs and other chemotherapy, putting all of those together in an [endocrine receptor]–positive metastatic breast cancer. I think we can pretty reasonably bring them to 5, 6, or 7 years of overall survival when putting together [these therapies and] adding on the new ADC benefit. 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She advocates for using resources, colleagues, and community outreach to ensure diverse patient populations have access to clinical trials while also highlighting the need to address personal biases among providers and to educate on these biases.","_key":"7a37c8193dcb","_type":"span"}],"_type":"block","style":"normal","_key":"187258b6cfa3","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"69ae9b3aa118"}],"_type":"block","style":"normal","_key":"b5e7baca3499"},{"style":"normal","_key":"dc33bf47af95","markDefs":[],"children":[{"text":"This transcript has been lightly edited.","_key":"78466aa5a8030","_type":"span","marks":["em"]},{"marks":[],"text":"\n","_key":"618ab7380f1f0","_type":"span"}],"_type":"block"},{"_key":"099c1a20b9a2","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"9556f0bbfe150"}],"_type":"block","style":"normal"},{"style":"normal","_key":"215a7abd5fda","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"","_key":"596c530fcf5b"}],"_type":"block"},{"_key":"85fc4e0840e1","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How can we accelerate the development and translation of novel therapies into clinical practice? What role can collaboration between researchers, clinicians, and industry play in this process?","_key":"dc238b51a0170"}],"_type":"block","style":"normal"},{"style":"normal","_key":"50123e62ec72","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5ae2dcd9127b0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"We can't move the needle forward if we don't access clinical trials and if we don't bring them to patients, in my opinion, in the community. It's great to have academic centers who are collaborators and are pushing the needle forward in other ways, but I think our patients really live in communities and they want to be able to be treated in their communities without having to travel far for that treatment. In my opinion, the collaboration has to be uniform between pharmaceutical companies, where many of our sponsors [are], academics, and community; it really has to be a blend of the 3.","_key":"c326c4be2d0a0"}],"_type":"block","style":"normal","_key":"99b99a209817"},{"_type":"block","style":"normal","_key":"9e9c4a05c633","markDefs":[],"children":[{"text":"","_key":"b8ffdd2748aa0","_type":"span","marks":[]}]},{"_key":"5a0b2338d084","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The way to do it is research, and the way to also do that effectively is to do a better job at making inclusion criteria for trials more representative of who our patients truly are. This has become topline priority for the FDA with the idea that minorities are representing less than 5% of all our clinical trials, and that does a disservice to the true representation of what our communities are like.","_key":"ee2c2971cc470"}],"_type":"block","style":"normal"},{"style":"normal","_key":"d11af6c90e69","markDefs":[],"children":[{"text":"","_key":"bb72531637be0","_type":"span","marks":[]}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"I think if we do a better job at offering clinical trials, dismantle the idea that clinical trials are often taboo for many communities, and do a better job at education, then bringing this to the community is probably the way to move forward.","_key":"f4d736320a3b0"}],"_type":"block","style":"normal","_key":"2ec59366bfd7","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"d654188f245b","_type":"span"}],"_type":"block","style":"normal","_key":"b2660179b94e"},{"_type":"block","style":"normal","_key":"79f32d940023","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How can we ensure that patients with HR+/HER2– breast cancer have access to the latest and most effective treatments, regardless of their socioeconomic status or geographic location?","_key":"2a6242e4463a0"}]},{"_key":"9ce5821ca1c0","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"76fb2dd388f2"}],"_type":"block","style":"normal"},{"_key":"1855dc58f557","markDefs":[],"children":[{"text":"I think representation on the other side of the forward-facing patient is super important. In my opinion, I think if you have a physician who represents a portion of that population (ie, a Latinx physician, an African American physician), you get an immediate sense of trust. It really does happen. I've seen that be the case. I'm Latinx myself, and being able to speak in the language that they feel most comfortable with, not having to have a intermediate person or a translator is a huge way to build trust.","_key":"5ecc220ad37d0","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"e2fd6cec5f3f0"}],"_type":"block","style":"normal","_key":"272080b1c7d3","markDefs":[]},{"_type":"block","style":"normal","_key":"e7be8649c913","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We can't all be of all different backgrounds in oncology, but what we can do is use our resources, use our colleagues, use educators, use nurse navigators, use the collaborative relationships that already exists in coming out to the community and make that happen.","_key":"1527563640480"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"da13d158ed330"}],"_type":"block","style":"normal","_key":"e891c71e01c4"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"But I think the most important thing also, which I believe wholeheartedly in, is the idea of dismantling some of our own misconceptions about who are the ideal patients. I think all of us have biases built in, no one can say they don't. I think whether that's because someone comes from a less accessible area of town and doesn't have a ride, maybe we would never present a trial to them, whereas we might have the idea that someone else could and would accept a clinical trial, and therefore why waste your time bringing that to their attention? I think checking in with biases is super important from a provider and physician perspective as well.","_key":"71ba2e2b78fc0"}],"_type":"block","style":"normal","_key":"02a38734f9c2"},{"children":[{"_type":"span","marks":[],"text":"","_key":"854664b349d00"}],"_type":"block","style":"normal","_key":"0cd799907e4f","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"To summarize, it's really education, checking biases, making sure that community-based practices have access to those clinical trials. 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She focused on 2 FDA-approved antibody drug conjugates (ADCs): trastuzumab deruxtecan (T-DXd; Enhertu; Daiichi Sankyo/AstraZeneca) and sacituzumab govitecan (SG), which have both demonstrated improved PFS and OS in metastatic breast cancer. \n","_key":"192590fe2e21"}],"_type":"block","style":"normal"},{"_key":"55519cc7a2a4","markDefs":[],"children":[{"marks":["em"],"text":"This transcript has been lightly edited.","_key":"db6951d6ffa20","_type":"span"},{"_type":"span","marks":[],"text":"\n","_key":"782f469e97390"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"2ed519df73b3","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"5148b24bacff0"}]},{"children":[{"_type":"span","marks":["strong","underline"],"text":"","_key":"4169f25d37d8"}],"_type":"block","style":"normal","_key":"3925eb0af5f6","markDefs":[]},{"markDefs":[],"children":[{"text":"Can you discuss some of the emerging therapies for HR+/HER2– breast cancer, such as CDK4/6 inhibitors, poly ADP-ribose polymerase (PARP) inhibitors, and antibody-drug conjugates?","_key":"25dc426bd5b30","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"9072cfc77b94"},{"_type":"block","style":"normal","_key":"6098bd431861","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"88448e5c2b0e0"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I'm so excited we have so many treatment options we can offer our patients right now. In the adjuvant setting, now we can offer CDK4/6 inhibitors in addition to traditional aromatase inhibitors and tamoxifen, and in addition to the ovarian function suppressions.","_key":"a90bf41f8b810"}],"_type":"block","style":"normal","_key":"73cbf20c7056"},{"style":"normal","_key":"665a2fd87e5b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d93307394c2d0"}],"_type":"block"},{"style":"normal","_key":"6019acd0ac5d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Previously, we could only use abemaciclib, and now we have a new ribociclib. If a patient is unable to tolerate abemaciclib, we can try ribociclib. The ribociclib population is more broad, so if the patients are not eligible for abemaciclib, we can offer the patients ribociclib. This is a CDK4/6 inhibitor in the nonmetastatic setting.","_key":"0581706c430a0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\n","_key":"b7b979f95e2a0"}],"_type":"block","style":"normal","_key":"00f4b843ac9d"},{"_key":"d734e0be69dc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"In the metastatic setting, CDK4/6 inhibitors plus aromatase inhibitors as the first line of therapy has significantly improved the PFS and the overall survival as well. We have 3 CDK4/6 inhibitors we can offer to our patients. This is good because if a patient could not tolerate 1 CDK4/6 inhibitors, we can try different ones. We have many options for our patients in the metastatic setting right now.","_key":"6d88bf43eb520"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f89a150010cf"}],"_type":"block","style":"normal","_key":"107c41b72e59"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ADCs are another exciting field. We have 2 FDA-approved ADCs right now. One is T-DXd, another one is a sacituzumab govitecan, and we're expecting the third ADC, Dato-DXd, that could potentially could be approved. We're waiting for that news. So those are very exciting drugs.","_key":"9ee26cb9e5240"}],"_type":"block","style":"normal","_key":"988175ee8422"},{"style":"normal","_key":"1bfcba134d6e","markDefs":[],"children":[{"marks":[],"text":"","_key":"26c2380bbd050","_type":"span"}],"_type":"block"},{"children":[{"text":"T-DXd and Enhertu have both have been used in ER-positive, HER2-negative [HER2–] metastatic breast cancer. They not only improve the PFS, but also improve the overall survival. It's really hard to see any drugs improve overall survival in the metastatic setting, and they both achieved that primary end point. Those are very exciting drugs.","_key":"4230511696d80","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"517a332bcac7","markDefs":[]},{"_key":"33ff431af6c6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"aa61f32313890"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"The third one, Dato-DXd [datopotamab deruxtecan], if it is approved, I think will potentially be a good option for our patients. The Dato-DXd is based on the ","_key":"fdf36ba863bf0"},{"_type":"span","marks":["f2b18fe27749"],"text":"TROPION-Breast01","_key":"fdf36ba863bf1"},{"_key":"fdf36ba863bf2","_type":"span","marks":[],"text":", a phase 3 study comparing the physicians’ choice among patients with ER-positive, HER2-low or HER2-negative metastatic breast cancer who have had aromatase inhibitor plus a CDK4/6 inhibitor, and also have had 1 line of chemotherapy. Dato-DXd significantly improved PFS compared with the physicians’ choice.\n"}],"_type":"block","style":"normal","_key":"2146d7761df3","markDefs":[{"href":"https://www.astrazeneca.com/media-centre/press-releases/2024/datopotamab-deruxtecan-final-overall-survival-results-reported-in-patients-with-metastatic-hr-positive-her2-low-or-negative-breast-cancer-in-tropion-breast01-phase-iii-trial.html","_key":"f2b18fe27749","nofollow":true,"blank":true,"_type":"link"}]},{"style":"normal","_key":"1cc335b506f9","markDefs":[],"children":[{"_key":"4d6f7a4a863d0","_type":"span","marks":[],"text":"We don't have the overall survival data yet. However, based on the toxicity profile and the PFS data, this drug seems very well tolerated. It is beneficial in terms of improved PFS, and the treatment schedule is pretty benign as well. Treatment is every 3 weeks compared with saci [SG] that is day 1, day 8, every 21 days over 1 cycle.\n"}],"_type":"block"},{"_key":"6c0ab8f3e0f6","markDefs":[],"children":[{"_key":"e6bf58fd241a0","_type":"span","marks":[],"text":"Another benefit of this medication is we are not too worried about the grade 5 ILD [interstitial lung disease] with Dato-DXd compared with T-DXd. Just my personal preference. I think the Dato-DXd compared with saci has a benefit of a more convenient treatment schedule compared with T-DXd, [that] has less concern of ILD with much better tolerance. 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Burstein emphasized the importance in fostering patient-physician relationships to build trust and ultimately, gain a better understanding of the treatments they are undergoing.","_key":"8e76cd112f080"}],"_type":"block","style":"normal"},{"_key":"250925b8e10f","markDefs":[],"children":[{"_key":"500ef451a8c40","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_key":"d9e3d8e62d35","markDefs":[],"children":[{"_type":"span","marks":["em"],"text":"This transcript was lightly edited for clarity. 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