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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F43c5f2c6c49ebaa69598d1cda74c5d0d8af64130-5500x3759.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">February 7th 2025</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/keratinocyte-skin-cancer-surgery-considered-safe-effective-in-older-patients">Keratinocyte Skin Cancer Surgery Considered Safe, Effective in Older Patients</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/hayden-e-klein"><i>Hayden E. Klein</i></a></span></div></div><a href="/view/keratinocyte-skin-cancer-surgery-considered-safe-effective-in-older-patients"><a href="/view/keratinocyte-skin-cancer-surgery-considered-safe-effective-in-older-patients"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">A single-center study suggests the surgery is safe and effective even when tumors are large or located in high-risk areas.</p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/combination-immunotherapy-offers-new-pathway-for-skin-cancer-prevention"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" 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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F9a7b965a2bfbbde9b72a91c83869caf077dd25d9-9504x6336.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/combination-immunotherapy-offers-new-pathway-for-skin-cancer-prevention"><span class="text-sm text-gray-500">January 20th 2025</span></a><div><a class="text-[14px]" href="/view/combination-immunotherapy-offers-new-pathway-for-skin-cancer-prevention"><p class="line-clamp-4 text-hidden font-[500]">Combination Immunotherapy Offers New Pathway for Skin Cancer Prevention</p></a></div><div class="py-2"><div><span class="text-md 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style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="lg:object-cover object-contain " loading="lazy"/></noscript></span></div><div class="border-t-gray-100 border-t-2 pt-2 pb-2 flex-auto "><a href="/view/adjuvant-cemiplimab-significantly-improves-disease-free-survival-in-high-risk-skin-cancer"><span class="text-sm text-gray-500">January 17th 2025</span></a><div><a class="text-[14px]" href="/view/adjuvant-cemiplimab-significantly-improves-disease-free-survival-in-high-risk-skin-cancer"><p class="line-clamp-4 text-hidden font-[500]">Adjuvant Cemiplimab Significantly Improves Disease-Free Survival in High-Risk Skin Cancer</p></a></div><div class="py-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/hayden-e-klein"><i>Hayden E. 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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2Fa25fa5c52d62114d4c8b093330326d885e98b2e7-1280x720.jpg%2FTN%2520Neill%2520Gross.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-2915913710 content-wrap"><span class="jsx-2915913710 py-3 text-sm text-gray-500 text-left"><i class="jsx-2915913710">October 20th 2022</i></span><div class="jsx-2915913710 w-full h-fit mb-4"><p class="jsx-2915913710 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Neil Gross: QOL Improvement Likely Following Treatment With Cemiplimab for cSCC</p></div></div></div></a><a target="" style="scroll-snap-align:center;text-decoration:none" 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src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-187450181 content-wrap"><span class="jsx-187450181 py-3 text-sm text-gray-500 text-left"><i class="jsx-187450181">September 5th 2021</i></span><div class="jsx-187450181 w-full h-fit mb-4"><p class="jsx-187450181 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Todd Schlesinger on How Medical, Cosmetic, Research Dermatology Interact</p></div></div></div></a><a target="" style="scroll-snap-align:center;text-decoration:none" class="jsx-609564708 sm:w-[280px] xs:w-[240px] w-[65%] h-auto flex flex-col space-y-3 flex-none select-none no-underline" href="/view/dr-todd-schlesinger-morphology-immunosuppression-affect-actinic-keratosis-outcomes"><div class="jsx-609564708 w-full h-full flex flex-col overflow-hidden relative bg-white text-center"><div class="jsx-609564708 relative w-full shadow-md shadow-grey-800 aspect-video"><span style="box-sizing:border-box;display:block;overflow:hidden;width:initial;height:initial;background:none;opacity:1;border:0;margin:0;padding:0;position:absolute;top:0;left:0;bottom:0;right:0"><img alt="" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" decoding="async" data-nimg="fill" class="object-cover" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%"/><noscript><img alt="" sizes="100vw" srcSet="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=640&q=75 640w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=750&q=75 750w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=828&q=75 828w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1080&q=75 1080w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1200&q=75 1200w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=1920&q=75 1920w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=2048&q=75 2048w, /_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F4255be9fcafad3b56c0c2c1d320dd786082a951e-1280x720.jpg%2FSchelsinger%2520TN1.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-cover" loading="lazy"/></noscript></span></div><div class="jsx-609564708 content-wrap"><span class="jsx-609564708 py-3 text-sm text-gray-500 text-left"><i class="jsx-609564708">August 19th 2021</i></span><div class="jsx-609564708 w-full h-fit mb-4"><p class="jsx-609564708 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Dr Todd Schlesinger: Morphology, Immunosuppression Affect Actinic Keratosis Outcomes</p></div></div></div></a></div></div></div><div class="flex items-center space-x-4 border-0 border-b border-secondary select-none py-1"><h2 class="text-3xl text-primary">More News</h2></div><div class="flex flex-wrap w-full pb-4"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/community-engagement-culturally-tailored-care-as-a-gateway-to-advancing-health-equity"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f30336a5a8b8ab151d51f69d588f0e1507c08c2e-5580x3376.jpg?fit=crop&auto=format" alt="Advancing health equity can be achieved through community engagement | image credit: Andrii - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/community-engagement-culturally-tailored-care-as-a-gateway-to-advancing-health-equity">Community Engagement, Culturally Tailored Care as a Gateway to Advancing Health Equity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/community-engagement-culturally-tailored-care-as-a-gateway-to-advancing-health-equity"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Many talks at the Association of Cancer Care Centers (ACCC) 41st National Oncology Conference advocated for the adoption of culturally relevant care, the leveraging of community partnerships, and community engagement to build better trust with patients and improve outcomes. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approved-red-light-led-lamp-released-for-patients-with-actinic-keratosis"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/af646e084b47344c9cbff937213b777975b4b1c6-7000x4000.jpg?fit=crop&auto=format" alt="Biofrontera's red-light LED has been approved for the treatment of actinic keratosis | image credit: marog-pixcells - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approved-red-light-led-lamp-released-for-patients-with-actinic-keratosis">FDA-Approved Red-Light LED Lamp Released for Patients With Actinic Keratosis</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/tim-smith">Tim Smith</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approved-red-light-led-lamp-released-for-patients-with-actinic-keratosis"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The announcement followed the release of the RhodoLED XL red light-emitting lamp, to be used in combination with aminolevulinic acid hydrochloride topical gel, 10% for actinic keratoses.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/certain-melanoma-subtype-may-be-more-sensitive-to-nk-t-cells"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/fb29f2bd74759a49a6ae1b0c024645d81f7df489-1200x728.jpg?fit=crop&auto=format" alt="skin cancer | Image Credit: uffoow-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/certain-melanoma-subtype-may-be-more-sensitive-to-nk-t-cells">Certain Melanoma Subtype May Be More Sensitive to NK, T Cells</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ajmc-contributor">AJMC Contributor</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/certain-melanoma-subtype-may-be-more-sensitive-to-nk-t-cells"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Of 7 subtypes identified 10,000 melanoma cells, C4 Melanoma COCO1A was the only to show indications of being more sensitive to natural killer (NK) and T cells. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/further-medicaid-expansion-would-benefit-patients-with-melanoma-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/1122d3fee53239bdca1a52dd18e722c1766cf9d4-3000x2000.jpg?fit=crop&auto=format" alt="Medicaid coverage | image credit: nelzajamal - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/further-medicaid-expansion-would-benefit-patients-with-melanoma-study-finds">Further Medicaid Expansion Would Benefit Patients With Melanoma, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/further-medicaid-expansion-would-benefit-patients-with-melanoma-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A poster presented at the 2024 American Society of Clinical Oncology annual meeting argued the benefits that Medicaid expansion can bring to patients with melanoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/management-of-melanoma-during-pregnancy-explored-at-asco-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/bbd432dfafc0987e759b114f947610044531a640-5760x3840.jpg?fit=crop&auto=format" alt="Pregnancy-associated melanoma is a rare occurence that impacts 1 in 2200 pregnancies | image credit: Alik Mulikov - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/management-of-melanoma-during-pregnancy-explored-at-asco-2024">Management of Melanoma During Pregnancy Explored at ASCO 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/management-of-melanoma-during-pregnancy-explored-at-asco-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Two posters presented at the 2024 American Society of Clinical Oncology annual meeting revealed real-world data on the outcomes and management strategies associated with melanoma during pregnancy. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/link-between-skin-cancer-and-immunosuppressants-needs-further-research"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a5b4103689ced19fd65f513e6161887e1958fe94-4256x2832.jpg?fit=crop&auto=format" alt="Skin cancer risk may be associated with immunosuppressant medication, although multiple studies exploring this relationship have not drawn concrete conclusions | image credit: Damian Gretka - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/link-between-skin-cancer-and-immunosuppressants-needs-further-research">Link Between Skin Cancer and Immunosuppressants Needs Further Research</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/link-between-skin-cancer-and-immunosuppressants-needs-further-research"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">At the 2024 American Society of Clinical Oncology annual meeting, an abstract presenting real-world data stressed the need for further research regarding the association between immunosuppressant medication and the development of skin cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/metformin-for-melanoma-holds-potential-benefits-for-patients"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2318b722a4a662e5955335c38847fb8d7b247250-5184x3456.jpg?fit=crop&auto=format" alt="Skin cancer checkup concept with cancer ribbon | image credit: Monstar Studio - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">June 10th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/metformin-for-melanoma-holds-potential-benefits-for-patients">Metformin for Melanoma Holds Potential Benefits for Patients</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/metformin-for-melanoma-holds-potential-benefits-for-patients"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Metformin showed promise for improving the overall survival rate of patients with melanoma; however, this result may be an indirect consequence of the drug.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/keratinocyte-cancers-most-commonly-located-on-the-head-and-neck-us-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9df8a46341125e61a09e5a1177a2df2642316dd7-5596x3735.jpg?fit=crop&auto=format" alt="Skin cancer screening | Image credit: Viktoriia - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 31st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/keratinocyte-cancers-most-commonly-located-on-the-head-and-neck-us-study-finds">Keratinocyte Cancers Most Commonly Located on the Head and Neck, US Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/keratinocyte-cancers-most-commonly-located-on-the-head-and-neck-us-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A large Medicare cohort study found that the most common locations of procedurally treated keratinocyte cancers in the US were the head and/or neck for both squamous cell carcinomas and basal cell carcinomas.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/concerns-about-ai-based-dermatologic-mobile-apps"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ee1d2190b4c5315ed992a68470e4fede58065f41-8000x4500.jpg?fit=crop&auto=format" alt="Person Operating Smartphone | image credit: Production Perig - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 31st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/concerns-about-ai-based-dermatologic-mobile-apps">Concerns About AI-Based Dermatologic Mobile Apps</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/concerns-about-ai-based-dermatologic-mobile-apps"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An analysis that overviewed dermatologic mobile apps with artificial intelligence (AI) features led researchers to voice concerns about the use of this technology in its current state. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-non-melanoma-skin-cancer-prefer-rsct-over-surgery"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/49a787244c60e4bfbf14283a08a5691985262d1f-5760x3840.jpg?fit=crop&auto=format" alt="Clinician Marking Non-melanoma Skin Cancer Lesion for Removal | image credit: Pixel-Shot - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-non-melanoma-skin-cancer-prefer-rsct-over-surgery">Patients With Nonmelanoma Skin Cancer Prefer RSCT Over Surgery</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-non-melanoma-skin-cancer-prefer-rsct-over-surgery"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A follow-up study utilizing interviews and survey responses demonstrates that patients prefer rhenium-188 skin cancer therapy (RSCT) over surgery in the treatment of their non-melanoma skin cancer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/patients-with-advanced-recurrent-melanoma-may-experience-lasting-aes-from-icm-therapy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/09602eea27441870c5adb11bd0ccd9e58bdd6e18-3873x3873.jpg?fit=crop&auto=format" alt="Adverse Drug Reaction Warning | image credit: Balint Radu - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-advanced-recurrent-melanoma-may-experience-lasting-aes-from-icm-therapy">Patients With Advanced, Recurrent Melanoma May Experience Lasting AEs From ICM Therapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/patients-with-advanced-recurrent-melanoma-may-experience-lasting-aes-from-icm-therapy"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A cross-sectional, mixed-methods study found that adverse effects (AEs) can occur even after 1 year of treatment with immune checkpoint modulator (ICM) therapy in patients with melanoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exploration-into-super-giant-basal-cell-carcinoma-calls-for-future-research"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cdda2265f11c4ef234ae5bf5dfea3b66f26c2ca0-3872x2592.jpg?fit=crop&auto=format" alt="Basal Cell Carcinoma | image credit: Laura Ballard - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">May 3rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exploration-into-super-giant-basal-cell-carcinoma-calls-for-future-research">Exploration Into Super-Giant Basal Cell Carcinoma Calls for Future Research</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exploration-into-super-giant-basal-cell-carcinoma-calls-for-future-research"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A systematic analysis demonstrated the rarity of super-giant basal cell carcinomas and the need for further characterization of these understudied skin cancers.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/survivors-of-early-stage-melanoma-have-high-rates-of-fear-of-recurrence-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3a9eaa0e26753550c436e7d2300a4be50a577a7f-1280x854.jpg?fit=crop&auto=format" alt="Skin cancer check | Image credit: InsideCreativeHouse - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/survivors-of-early-stage-melanoma-have-high-rates-of-fear-of-recurrence-study-finds">Survivors of Early-Stage Melanoma Have High Rates of Fear of Recurrence, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/rose-mcnulty">Rose McNulty</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/survivors-of-early-stage-melanoma-have-high-rates-of-fear-of-recurrence-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The study aimed to improve the understanding of lived experiences and the fear of recurrence among survivors of localized, stage 0 to IIA cutaneous melanoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/exploration-of-melanoma-incidence-mortality-rates-urges-further-research"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/aea8de013a8a685730d0ffdfec9cb72997464eb1-6016x4000.jpg?fit=crop&auto=format" alt="Skin Check for Melanoma | image credit: cunaplus - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/exploration-of-melanoma-incidence-mortality-rates-urges-further-research">Exploration of Melanoma Incidence, Mortality Rates Urges Further Research</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/exploration-of-melanoma-incidence-mortality-rates-urges-further-research"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A retrospective analysis out of Denmark could not find a causal relationship to explain trends in melanoma incidence and mortality rates, demonstrating the need for more research in this area. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dr-michael-farwell-on-fdg-pet-ct-imaging-to-predict-immunotherapy-response-in-advanced-melanoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/52a97d33839a05d8f9f28015bcc1699307238a87-6696x3750.jpg?fit=crop&auto=format" alt="AI-Generated CT Equipment Concept | image credit: StraSyP - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dr-michael-farwell-on-fdg-pet-ct-imaging-to-predict-immunotherapy-response-in-advanced-melanoma">Dr Michael Farwell on FDG PET/CT Imaging to Predict Immunotherapy Response in Advanced Melanoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dr-michael-farwell-on-fdg-pet-ct-imaging-to-predict-immunotherapy-response-in-advanced-melanoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Michael Farwell, MD, associate professor of radiology at the Hospital of the University of Pennsylvania, provides insights into a study on the benefits of using 18F-fluorodeoxyglucose (FDG) PET/CT imaging to detect metabolic tumor changes in skin cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-based-smartphone-app-proves-reliable-in-diagnosis-of-melanoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ee1d2190b4c5315ed992a68470e4fede58065f41-8000x4500.jpg?fit=crop&auto=format" alt="AI-Based Smartphone App Proves Reliable in Diagnosis of Melanoma" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 9th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-based-smartphone-app-proves-reliable-in-diagnosis-of-melanoma">AI-Based Smartphone App Proves Reliable in Diagnosis of Melanoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-based-smartphone-app-proves-reliable-in-diagnosis-of-melanoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A prospective study evaluating the efficacy of an artificial intelligence (AI)–based clinical support system further demonstrated the reliability of AI or machine learning as a diagnostic tool in skin cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/yes-associated-protein-may-hold-prognostic-value-in-cutaneous-melanoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/328bb390c432dc528174da7e6aba1b6155275fcc-6415x4277.jpg?fit=crop&auto=format" alt="Cancerous Cells Concept | image credit: Dr_Microbe - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">April 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/yes-associated-protein-may-hold-prognostic-value-in-cutaneous-melanoma">Yes-Associated Protein May Hold Prognostic Value in Cutaneous Melanoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/yes-associated-protein-may-hold-prognostic-value-in-cutaneous-melanoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A retrospective study analyzing tissue assays from patients with cutaneous melanoma demonstrated the promise of yes-associated protein (YAP) as a predictive biomarker for melanoma prognosis. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/ai-accurately-predicts-skin-cancer-risk-based-on-2d-facial-images"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/dd66ee40028157be31a3be7760c1c526d55e61a3-5000x2661.jpg?fit=crop&auto=format" alt="Collaboration With AI Concept | image credit: ipopba - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/ai-accurately-predicts-skin-cancer-risk-based-on-2d-facial-images">AI Accurately Predicts Skin Cancer Risk Based on 2D Facial Images</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/ai-accurately-predicts-skin-cancer-risk-based-on-2d-facial-images"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An artificial intelligence (AI) mode was more accurate in assessing patient risks for skin cancer through the analysis of 2D facial images compared with more traditional risk-factor screening. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/risk-for-second-primary-melanoma-increases-after-primary-melanoma-diagnosis-as-men-age"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7e8170effb7dd3a1c5193281c3ff1f4992ad3633-6720x4480.jpg?fit=crop&auto=format" alt="Man Prior to Skin Examination | image credit: New Africa - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 28th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/risk-for-second-primary-melanoma-increases-after-primary-melanoma-diagnosis-as-men-age">Risk for Second Primary Melanoma Increases After Primary Melanoma Diagnosis as Men Age</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/risk-for-second-primary-melanoma-increases-after-primary-melanoma-diagnosis-as-men-age"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A population-based cohort study out of Norway has found that older men have a higher risk of developing second primary invasive melanoma following an initial primary melanoma, suggesting the benefits of increased surveillance in these patients. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/radiation-therapy-associated-with-elevated-skin-cancer-risk-in-patients-with-breast-cancer"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/84239c2e05813bbe42dffe9681aafbe79da6d11e-5000x3000.jpg?fit=crop&auto=format" alt="Radiation Therapy Model | image credit: Andrii - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/radiation-therapy-associated-with-elevated-skin-cancer-risk-in-patients-with-breast-cancer">Radiation Therapy Associated With Elevated Skin Cancer Risk in Patients With Breast Cancer</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/radiation-therapy-associated-with-elevated-skin-cancer-risk-in-patients-with-breast-cancer"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Results from a retrospective cohort study analyzing patients with breast cancer bolster reports of an association between radiation therapy and subsequent risks of skin cancers. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/federated-learning-models-show-potential-in-melanoma-nevus-classification-but-improvements-needed"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4e570454cea8198115559c1f48b04eedfda5938e-4800x3000.jpg?fit=crop&auto=format" alt="AI Chip | Image credit: Shuo - stock.adobe.come" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 16th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/federated-learning-models-show-potential-in-melanoma-nevus-classification-but-improvements-needed">Federated Learning Models Show Potential in Melanoma-Nevus Classification, but Improvements Needed</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/federated-learning-models-show-potential-in-melanoma-nevus-classification-but-improvements-needed"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A multicentric, single-arm diagnostic study created a decentralized federated learning model for the classification of invasive melanomas and nevi, showcasing comparable results to centralized data models. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/use-of-immunohistochemistry-in-melanoma-diagnosis-has-grown-but-more-research-is-needed"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f558e0466476282ac8864c6fec0b249c98bc63b8-6000x4000.jpg?fit=crop&auto=format" alt="Woman Checking Skin for Signs of Melanoma | image credit: MW Photography - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/use-of-immunohistochemistry-in-melanoma-diagnosis-has-grown-but-more-research-is-needed">Use of Immunohistochemistry in Melanoma Diagnosis Has Grown, but More Research Is Needed</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/use-of-immunohistochemistry-in-melanoma-diagnosis-has-grown-but-more-research-is-needed"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A retrospective, cross-sectional study analyzed national trends of immunohistochemistry (IHC) use in the diagnosis of melanoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/more-research-needed-to-address-discordance-in-skin-cancer-treatment-guidelines"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/55127133e904f4d2f7aa555bf19c9da262b0834f-5184x3456.jpg?fit=crop&auto=format" alt="Guidelines Spelled in Blocks | image credit: chrupka - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">March 8th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/more-research-needed-to-address-discordance-in-skin-cancer-treatment-guidelines">More Research Needed to Address Discordance in Skin Cancer Treatment Guidelines </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/more-research-needed-to-address-discordance-in-skin-cancer-treatment-guidelines"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A comparative analysis on skin cancer management guidelines in the US highlights the necessity of further research in this subject. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-overdiagnosis-in-white-americans-is-increasing"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/670281d7750b86e983459bf239dd3b5d23202869-6002x4001.jpg?fit=crop&auto=format" alt="Melanoma on Skin | image credit: Ocskay Mark - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-overdiagnosis-in-white-americans-is-increasing">Skin Cancer Overdiagnosis in White Americans Is Increasing, Study Says</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-overdiagnosis-in-white-americans-is-increasing"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">An ecological study revealed increasing rates of skin cancer overdiagnosis in white Americans. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-treatment-landscape-is-evolving-with-ai"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/173b86388726b8fcd7d574469efbfd0a79d3b93a-5760x3468.jpg?fit=crop&auto=format" alt="AI Display Concept | image credit: Tierney - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-treatment-landscape-is-evolving-with-ai">Skin Cancer Treatment Landscape Is Evolving With AI</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/skin-cancer-treatment-landscape-is-evolving-with-ai"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Andrew Ress, MD, discusses the novel integration of artificial intelligence (AI) into the skin cancer treatment landscape. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/clinical-data-lacking-on-black-patients-with-melanoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/74f8c84fc89c4b20fc14a54b11eda1975bddd8e7-6720x4480.jpg?fit=crop&auto=format" alt="Preventative Melanoma Screening | image credit: sofiko14" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/clinical-data-lacking-on-black-patients-with-melanoma">Clinical Data Lacking on Black Patients With Melanoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/clinical-data-lacking-on-black-patients-with-melanoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A single-institution, retrospective cohort study evaluates knowledge gaps in clinical data on Black patients with melanoma. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/predisposition-to-early-onset-merkel-cell-carcinoma-linked-to-genetic-variants"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d1bdaee0b8f3cb2e80a02d557b48cb11a07765f-3840x2160.jpg?fit=crop&auto=format" alt="Genome Sequencing Model | image credit: catalin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/predisposition-to-early-onset-merkel-cell-carcinoma-linked-to-genetic-variants">Predisposition to Early-Onset Merkel Cell Carcinoma Linked to Genetic Variants</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/predisposition-to-early-onset-merkel-cell-carcinoma-linked-to-genetic-variants"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A case-control study found that patients with early-onset Merkel cell carcinoma exhibited genetic variations associated with the development of their disease. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/stigma-discrimination-impact-sexual-and-gender-minority-perspectives-on-full-body-skin-examinations-study-finds"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/621840a4980c33934e1a5f0d81660058fc023960-5760x3840.jpg?fit=crop&auto=format" alt="Clinician Performing Skin Examination | image credit: Peakstock - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/stigma-discrimination-impact-sexual-and-gender-minority-perspectives-on-full-body-skin-examinations-study-finds">Stigma, Discrimination Impact Sexual and Gender Minority Perspectives on Full-Body Skin Examinations, Study Finds</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/stigma-discrimination-impact-sexual-and-gender-minority-perspectives-on-full-body-skin-examinations-study-finds"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">A survey revealed the influence of prior stigmatic or discriminatory experiences on sexual and gender minority (SGM) patients’ perceptions of screening for skin cancer, stressing the need for affirming clinical settings.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/40-gep-test-utilization-can-mitigate-financial-burden-of-cutaneous-squamous-cell-carcinoma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c8ea67331850fe0f812a0f724392159704b056e6-6000x4000.jpg?fit=crop&auto=format" alt="Piggy Bank With Stethoscope | image credit: Nudphon - stock.adobe.com " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">February 1st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/40-gep-test-utilization-can-mitigate-financial-burden-of-cutaneous-squamous-cell-carcinoma">40-GEP Test Utilization Can Mitigate Financial Burden of Cutaneous Squamous Cell Carcinoma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/40-gep-test-utilization-can-mitigate-financial-burden-of-cutaneous-squamous-cell-carcinoma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Medicare-eligible patients with cutaneous squamous cell carcinoma (cSCC) could save on health care costs by utilizing the 40-gene expression profile (40-GEP) to guide treatment decisions. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/natural-hair-color-identified-as-potential-skin-cancer-risk-factor"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7a8f5b8d6db61f94038607329ff7287de0839ce4-3451x2606.jpg?fit=crop&auto=format" alt="Hair Color Spectrum | image credit: Elvira - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 23rd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/natural-hair-color-identified-as-potential-skin-cancer-risk-factor">Natural Hair Color Identified as Potential Skin Cancer Risk Factor </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/natural-hair-color-identified-as-potential-skin-cancer-risk-factor"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Results from a meta-analysis suggest a correlation between natural hair color and the development of skin cancer. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/skincancer?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/skincancer?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/skincancer?page=3">3</a><a class="px-4 py-2 border-y border-r 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Gross, MD, FACS, head and neck surgeon and director of clinical research in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center","_key":"22e84fe32a40","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"311297f98738"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"34da3606b7870"}],"_type":"block","style":"normal","_key":"c922cf9c42dd"},{"_key":"f6fed391bc1c","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"fe564c764f090"}],"_type":"block","style":"normal"},{"_key":"ad66b441075c","markDefs":[],"children":[{"text":"Can you discuss potential advantages for cemiplimab in early-stage disease?","_key":"df3c519faf930","_type":"span","marks":["strong"]}],"_type":"block","style":"normal"},{"children":[{"text":"","_key":"6756b4d5c31d0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"1c02acbaaaa5","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Applying immunotherapy to an earlier-stage setting I think has the possibility of just improving the responses. So, the smaller the tumor, the earlier stage of tumor, I suspect the better the responses. We know this just comparing the neoadjuvant trial to what we’ve seen in patients with advanced unresectable disease.","_key":"f93ceec4abb20"}],"_type":"block","style":"normal","_key":"f57fb18043f5"},{"children":[{"marks":[],"text":"","_key":"19f8e4542c1c0","_type":"span"}],"_type":"block","style":"normal","_key":"e0f66074a1ef","markDefs":[]},{"_type":"block","style":"normal","_key":"c3bd8f16e25d","markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/dr-neil-gross-cemiplimab-is-producing-encouraging-results-in-resectable-cscc","_key":"b0aa572cbe92"}],"children":[{"text":"It does offer the potential for patients to avoid radiation in some cases. And I think in the future, there will be patients who can avoid surgery altogether, although I would caution that ","_key":"e50fb78021330","_type":"span","marks":[]},{"_type":"span","marks":["b0aa572cbe92"],"text":"in this trial, and in the pilot trial as well","_key":"e50fb78021331"},{"_type":"span","marks":[],"text":", we noticed that the imaging responses significantly underestimated the pathologic responses. So when it came time to do the surgery, looking at the scans, there was still something there, and it was only after surgery when they looked at the specimens under the microscope that they determined there was no residual cancer or just a small amount of residual viable cancer.","_key":"e50fb78021332"}]},{"_type":"block","style":"normal","_key":"2da03c52fc0f","markDefs":[],"children":[{"marks":[],"text":"","_key":"1385a1474afe0","_type":"span"}]},{"markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/dr-neil-gross-on-potential-impact-of-future-novel-treatments-for-cscc","_key":"ba0bfea8cc01"}],"children":[{"_type":"span","marks":[],"text":"So we still need either ","_key":"6f3c062706d30"},{"_type":"span","marks":["ba0bfea8cc01"],"text":"a biomarker","_key":"6f3c062706d31"},{"_type":"span","marks":[],"text":" or better imaging to help us understand who will or will not need surgery or just to help define the extent of surgery and adjuvant treatments.","_key":"6f3c062706d32"}],"_type":"block","style":"normal","_key":"62028da90276"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What’s on the horizon for cemiplimab investigation?","_key":"345515a065dc0"}],"_type":"block","style":"normal","_key":"f416bcb41780"},{"children":[{"_type":"span","marks":[],"text":"","_key":"4912abae93640"}],"_type":"block","style":"normal","_key":"cd1ce60c80a3","markDefs":[]},{"_key":"ca968d1abaf6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"It’s a very active time. There are lots of different thoughts about the next steps for this. There’s so many unanswered questions currently. We still don’t know the optimal number of neoadjuvant doses of immunotherapy. In the pilot trial, we used 2 doses. In the confirmatory trial, we used up to 4, with the hopes of extending or expanding the number of pathologic responses.","_key":"a8357adca5950"}],"_type":"block","style":"normal"},{"_key":"dee75c8f5a26","markDefs":[],"children":[{"_key":"5b09179f6d2e0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"1cc743adcffc","markDefs":[],"children":[{"marks":[],"text":"We don’t know which patients can safely avoid radiation therapy, and I think this could be an important question to answer in a cooperative group setting, perhaps. We don’t know which patients can avoid surgery or the extent that surgery can be reduced for patients who respond. This is another very, very important question.","_key":"ea881a7018410","_type":"span"}]},{"markDefs":[],"children":[{"marks":[],"text":"Ultimately, we need to understand how this stacks up to standard-of-care treatment. This is only done in a phase 3 setting, and I think those studies are being contemplated right now and planned but I’m not aware of anything that’s ready to go.","_key":"d8a03942cd320","_type":"span"}],"_type":"block","style":"normal","_key":"5cbde7d59bd1"},{"_key":"ec158149b3c4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"481c3f51a39f0"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"2740c452680c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The patient stories are just so powerful. Just meeting some of the patients who’ve gone through this treatment, they’re so grateful. They are some of the most grateful patients that I have. Just understanding the focus on improving of quality of life is just so important to patients.","_key":"f22ddd2175440"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"7c7d79f140a50"}],"_type":"block","style":"normal","_key":"c290c1ff2ea1"},{"markDefs":[],"children":[{"_key":"14ceabb865640","_type":"span","marks":[],"text":"We aim for cure, we expect to cure patients, but we really want to make patients whole on the back end as well, and this is just another tool in our armamentarium to help patients get through with the least amount of adverse effects long term."}],"_type":"block","style":"normal","_key":"0d79f2194f37"},{"_type":"block","style":"normal","_key":"61cadcfac4eb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3f77ffd69d970"}]}],"taxonomyMapping":[{"parent":{"_ref":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_type":"reference"},"_createdAt":"2021-03-25T18:46:14Z","_type":"taxonomy","name":"Skin Cancer","_id":"6630cdc5-805f-485c-89b0-cc7dc33596ea","perKeywordMapping":["Dermatologic Cancer","Health Equity Diversity \u0026 Inclusion"],"cmeType":"per","_rev":"rs7eCk0lrr8LMiZP9GDe39","_updatedAt":"2023-11-03T18:21:43Z","summary":[{"_type":"block","style":"normal","_key":"af6b6692093c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"b2ad2a1380d10"},{"_type":"span","marks":["em"],"text":"AJMC® ","_key":"b2ad2a1380d11"},{"marks":[],"text":"Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.","_key":"b2ad2a1380d12","_type":"span"}]}],"identifier":"skincancer"},{"identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z"},{"_createdAt":"2020-03-30T19:16:54Z","_rev":"xqhc4WIQcOa1P2rns6bqkh","name":"Interviews","_id":"2d909731-8acf-4e3d-8962-d59b0da85320","_updatedAt":"2023-10-30T17:48:32Z","identifier":"interviews","sortOrder":3,"_type":"taxonomy"},{"_rev":"52vAUxG62nnEnK65ZDo5dG","identifier":"healthcare-delivery","parent":{"_type":"reference","_ref":"15012229-f713-4f0a-8f82-7667530bb382"},"_createdAt":"2020-05-04T23:46:13Z","_type":"taxonomy","name":"Health Care Delivery","_id":"topic_healthcare-delivery","_updatedAt":"2022-11-29T18:34:57Z"}]},{"_createdAt":"2022-11-11T16:07:14Z","is_visible":true,"title":"Dr Neil Gross on Potential Impact of Future Novel Treatments for cSCC","_updatedAt":"2022-11-27T17:39:52Z","authorMapping":[{"profileImage":{"_type":"mainImage","alt":"Maggie L. 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She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal","_key":"643be033259e","markDefs":[]},{"style":"normal","_key":"f4070c315fab","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/maggielshaw/","_key":"159c764717fb"}],"children":[{"marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on ","_key":"8e1abe71bcd2","_type":"span"},{"marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1","_type":"span"},{"_key":"abc0e18a29ce2","_type":"span","marks":[],"text":"."}],"_type":"block"}]}],"summary":"Currently, there is no treatment approved for resectable cutaneous squamous cell carcinoma (cSCC), nor do we have biomarkers to predict treatment response, noted Neil D. 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treatment approved for resectable cutaneous squamous cell carcinoma (cSCC), nor do we have biomarkers to predict treatment response. There is room for improvement, noted Neil D. Gross, MD, FACS, head and neck surgeon and director of clinical research in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center"}],"_type":"block"},{"children":[{"_key":"2d5d54c562a80","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"72c69dcbac72","markDefs":[]},{"_type":"block","style":"normal","_key":"9bc28ea5524c","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"f091a4e52a000"}]},{"_type":"block","style":"normal","_key":"0bf18a680caa","markDefs":[],"children":[{"marks":["strong"],"text":"What must future treatments for cSCC address for adverse effects beyond the physical?","_key":"e58e2ad0961c0","_type":"span"}]},{"markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/dr-neil-gross-cemiplimab-is-producing-encouraging-results-in-resectable-cscc","_key":"534f05e68521"}],"children":[{"text":"There’s no systemic therapy approved for cutaneous squamous cell carcinoma in the resectable setting. Immunotherapy is approved for patients with unresectable, or metastatic, disease, and it can improve survival for these patients; there can be durable disease control in that setting. ","_key":"dd1870b7124f0","_type":"span","marks":[]},{"marks":["534f05e68521"],"text":"This study","_key":"dd1870b7124f1","_type":"span"},{"_type":"span","marks":[],"text":" was designed to push it earlier into treatment, 1, to see if importantly we could improve quality of life, if we could spare patients functionally devastating surgery and potentially avoid radiation.","_key":"dd1870b7124f2"}],"_type":"block","style":"normal","_key":"d4c7f7500da1"},{"_type":"block","style":"normal","_key":"d6447359b242","markDefs":[],"children":[{"_key":"6041a379c7e30","_type":"span","marks":[],"text":""}]},{"children":[{"_key":"1d8ab67e220f0","_type":"span","marks":[],"text":"But it also has the opportunity to improve outcomes for patients as well. I think that is yet to be determined. And this will need to be compared to a standard-of-care approach in a phase 3 setting, I think, to be definitive evidence. But I’m confident that there is room for improvement in how we’re currently doing things and that this approach has a very good chance of beating the alternative."}],"_type":"block","style":"normal","_key":"1042419e3267","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"556c4fa28bfb0"}],"_type":"block","style":"normal","_key":"8bdb9dbe2afb"},{"children":[{"_type":"span","marks":["strong"],"text":"Is there potential for biomarkers in the space?","_key":"a87187c773e90"}],"_type":"block","style":"normal","_key":"39138db9fc32","markDefs":[]},{"_type":"block","style":"normal","_key":"7ef64675441f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"We don’t know currently which patients will respond to neoadjuvant treatment and which ones will not. We don’t have a biomarker currently. We looked in this study at tumor mutational burden, we looked at PD-L1 status; we’ve collected circulating tumor DNA, and that is being analyzed. But as of yet, we don’t have predictors of response to treatment. But that’s going to be critical moving forward. I think if we can identify biomarkers of response and really select our patients better for treatment, then it’ll be a win-win for everyone.","_key":"9efa9b736e460"}]},{"style":"normal","_key":"726d07266e53","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"768500fdbb340"}],"_type":"block"},{"markDefs":[],"children":[{"marks":[],"text":"One thing that’s really nice about this approach, the neoadjuvant approach, is that you can see the responses almost in real time. Patients will tell you that it’s improving. Patients have even told me that they’ve seen other skin cancers or skin lesions fall off during the neoadjuvant treatment or that their tumor itself, they felt it shrink or have seen it shrink. And we’ve seen this on imaging as well. So, you can measure the responses and see how it’s working. And if it’s working, great, you can continue. And if it’s not, you can shift gears and you can always go to a standard approach of surgery and radiation for advanced cancer.","_key":"8727a26afc040","_type":"span"}],"_type":"block","style":"normal","_key":"c2f2293702f8"}],"ExcludeFromPubMedXML":false,"link":"/view/dr-neil-gross-on-potential-impact-of-future-novel-treatments-for-cscc","source":null},{"body":[{"markDefs":[],"children":[{"text":"","_key":"f1fdfdf500bb0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"09c9c670ad92"},{"videoID":"6314742472112","source":"brightcove","_key":"2679d04be67e","_type":"video"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Neil D. Gross, MD, FACS, head and neck surgeon and director of clinical research in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center, discusses the results of study he and his team conducted in the setting of resectable stage II to IV cutaneous squamous cell carcinoma.","_key":"74022d549256"}],"_type":"block","style":"normal","_key":"84ca73ecc462"},{"_type":"block","style":"normal","_key":"32f6185540dc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"93c724e14b660"}]},{"_type":"block","style":"normal","_key":"c750e45e874e","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://oncologypro.esmo.org/meeting-resources/esmo-congress/neoadjuvant-cemiplimab-in-patients-pts-with-stage-ii-iv-m0-cutaneous-squamous-cell-carcinoma-cscc-primary-analysis-of-a-phase-ii-study","_key":"2f3b147aa5c1"}],"children":[{"_type":"span","marks":[],"text":"One of ","_key":"533e408dab560"},{"marks":["2f3b147aa5c1"],"text":"this study’s","_key":"533e408dab561","_type":"span"},{"_type":"span","marks":[],"text":" principal findings was a 51% complete pathologic response (pCR) rate, and this can have implications on reducing the need for more extensive surgery and radiation, Gross stated.","_key":"533e408dab562"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"50c9f9b3cd9f0"}],"_type":"block","style":"normal","_key":"0b6a36421241","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"3cd19bf13ffd0"}],"_type":"block","style":"normal","_key":"0319a2782bed"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"f5d0efb0a52f0","_type":"span"}],"_type":"block","style":"normal","_key":"50315cc0ff98"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"For those who may not view a 51% pathologic complete response rate as a good result, can you explain why this is a positive in the setting of advanced disease?","_key":"58acffa6d9ab0"}],"_type":"block","style":"normal","_key":"b5e45997b45c"},{"_type":"block","style":"normal","_key":"0284a393195b","markDefs":[],"children":[{"text":"","_key":"7c669b6357630","_type":"span","marks":[]}]},{"_type":"block","style":"normal","_key":"978e19ef3451","markDefs":[],"children":[{"_key":"bf0d3de024210","_type":"span","marks":[],"text":"Comparing this study to the current standard of care, which is surgery and radiation, there’s a lot of room for improvement. The effects of surgery and standard radiation can be devastating [in the] long term. In this study, just over half of the patients had a complete pathologic response. So they could have a more limited surgery, and those patients are probably safe not having radiation as well. Another about 13% of patients in this study—so overall, about two-thirds of patients had a deep pathologic response; most of those were complete pathologic responses—a smaller percentage had a near complete pathologic response. Those patients also do exceedingly well. They seem to behave similarly well to the patients who have a complete response."}]},{"_key":"1c918f95c942","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a69dcf3641eb0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Now, there are about a third of patients who just don’t respond as well. They may have a partial response. 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Gross, MD, FACS, head and neck surgeon and director of clinical research in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center.","_key":"a27f224f99292"}],"_type":"block","style":"normal","_key":"322e23321639","markDefs":[{"href":"https://www.ajmc.com/compendium/skincancer","_key":"7c2bf0ec3c6c","_type":"link"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"a126d1382a5c0"}],"_type":"block","style":"normal","_key":"0807c7113bf3","markDefs":[]},{"children":[{"marks":["strong","underline"],"text":"Transcript","_key":"c872836359dd0","_type":"span"}],"_type":"block","style":"normal","_key":"38456d215e5a","markDefs":[]},{"markDefs":[],"children":[{"marks":["strong"],"text":"How does cemiplimab fulfill an unmet need in the immunotherapy space?","_key":"4d51f0aac9900","_type":"span"}],"_type":"block","style":"normal","_key":"c07dc8768d03"},{"_key":"6753427b7fed","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3f626352fa530"}],"_type":"block","style":"normal"},{"style":"normal","_key":"999f2c45b26e","markDefs":[],"children":[{"_key":"19140af320630","_type":"span","marks":[],"text":"Immunotherapy is currently approved for use in unresectable cutaneous squamous cell carcinoma, and it’s really taken a page from the melanoma history. Immunotherapy has changed the practice of melanoma over the last decade or two, but it has yet to change the practice of [resectable] cutaneous squamous cell carcinoma. But both are uniquely responsive to immunotherapy and that has to do with the UV damage created from sun exposure and that is particularly well suited to immunotherapy."}],"_type":"block"},{"_type":"block","style":"normal","_key":"f584d36b2639","markDefs":[],"children":[{"_key":"3784d71377ad0","_type":"span","marks":[],"text":""}]},{"markDefs":[{"_type":"link","href":"https://www.ajmc.com/view/dr-neil-gross-cemiplimab-is-producing-encouraging-results-in-resectable-cscc","_key":"397b852a5d43"}],"children":[{"_type":"span","marks":[],"text":"Historically, patients with advanced cutaneous squamous cell carcinoma would be treated with surgery and radiation as the primary treatment—but that has a lot of potential toxicities. Surgeries can be functionally devastating, and radiation can have long-term side effects. Immunotherapy is approved for unresectable disease, but ","_key":"f2f515d76a860"},{"_type":"span","marks":["397b852a5d43"],"text":"this is the first study","_key":"f2f515d76a861"},{"_key":"f2f515d76a862","_type":"span","marks":[],"text":" to bring it earlier into the phase of care and to see if that can impact function and outcomes for patients."}],"_type":"block","style":"normal","_key":"fd200a526402"},{"children":[{"_key":"cc92e9d62a9c0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"37005b9f0195","markDefs":[]},{"_type":"block","style":"normal","_key":"8f0d960043a8","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So, we don’t have the long-term survival data for these patients, we don’t have the long-term quality-of-life data—those data are maturing—but I think we’ll see that the oncologic outcomes will be at least as good and durable. We know this from the long-term follow-up from the pilot trial, which is now over 3 years old. I think, importantly, it will demonstrate significant improvement in quality of life for patients, enabling less invasive surgeries, and for many patients, enabling the avoidance of radiation therapy, which can be very toxic in the head and neck region.","_key":"ffd9080dd0cd0"}]},{"children":[{"_type":"span","marks":[],"text":"","_key":"1f52a7e40d240"}],"_type":"block","style":"normal","_key":"9fb47db51a5c","markDefs":[]},{"style":"normal","_key":"2dbe51dadb69","markDefs":[],"children":[{"_type":"span","marks":[],"text":"It's such a grind going in for treatment over and over again. These patients, at least in the head and neck, they go for 6 weeks. The impact on quality of life is particularly dramatic in the head and neck; it’s just such a sensitive area. It’s where people eat, where they breathe, where they’re seen, or where they see from; it can affect their hearing, all their senses. So, it can be functionally devastating, the treatments, including radiation, and that can last a lifetime, too, not just during treatment.","_key":"08bc473c53c40"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"5631e063394b0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"06d80cb75a26"},{"markDefs":[],"children":[{"_key":"a807cd2c80d30","_type":"span","marks":[],"text":"The huge benefit of this approach is that I believe many patients will be able to avoid radiation treatment after surgery, and that’s where I think it can have a profound impact on quality of life long term. So a smaller surgery, more focused surgery, and perhaps avoiding radiation altogether. 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Lead investigator Neil D. Gross, MD, FACS, head and neck surgeon and director of clinical research in the Department of Head and Neck Surgery at MD Anderson, recently discussed these results with ","_key":"f6b6a7373fe92"},{"_type":"span","marks":["em"],"text":"The American Journal of Managed Care","_key":"f6b6a7373fe93"},{"_type":"span","marks":[],"text":"®","_key":"f6b6a7373fe94"},{"_type":"span","marks":["em"],"text":".","_key":"f6b6a7373fe95"}],"_type":"block","style":"normal"},{"_key":"c07855e45644","markDefs":[],"children":[{"marks":[],"text":"","_key":"cd2a5d0704900","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"01aaab7283c20"}],"_type":"block","style":"normal","_key":"ed363580b4d0"},{"_key":"8400bbbcffff","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"Can you discuss your study presented at ESMO on cemiplimab and why the monoclonal antibody is important in making progress against cSCC?","_key":"0a012804a9050"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"af9091ab6c740"}],"_type":"block","style":"normal","_key":"e249bcfccb9a","markDefs":[]},{"_key":"80fb12304586","markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://oncologypro.esmo.org/meeting-resources/esmo-congress/neoadjuvant-cemiplimab-in-patients-pts-with-stage-ii-iv-m0-cutaneous-squamous-cell-carcinoma-cscc-primary-analysis-of-a-phase-ii-study","_key":"b438253841ee"}],"children":[{"_type":"span","marks":[],"text":"I’m pleased to discuss ","_key":"1fb5aa4537b60"},{"_type":"span","marks":["b438253841ee"],"text":"our trial on neoadjuvant immunotherapy in stage II to IV cutaneous squamous cell carcinoma","_key":"1fb5aa4537b61"},{"_key":"1fb5aa4537b62","_type":"span","marks":[],"text":". It’s important to highlight up front that this is in resectable disease. Immunotherapy is approved for use in unresectable, or metastatic, cutaneous squamous cell carcinoma, but this is the first trial, other than a pilot trial we completed, to test immunotherapy in the neoadjuvant setting in resectable cutaneous squamous cell carcinoma."}],"_type":"block","style":"normal"},{"children":[{"marks":[],"text":"","_key":"f19a442e77990","_type":"span"}],"_type":"block","style":"normal","_key":"5b988997bf4d","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"The pilot study was performed here at MD Anderson; it included only 20 patients with resectable but advanced-stage disease, where the intent was really not to influence treatment. In that study, patients had to undergo the full extent of surgery after neoadjuvant therapy as they would have at baseline. We were really astounded to see the responses to treatment in that pilot trial. Over half of the patients had a complete pathologic response to treatment, and based on the strength of those results, it prompted a multicenter confirmatory trial that was reported at ESMO and ","_key":"199d88582b020"},{"_type":"span","marks":["be20592ef34a"],"text":"published in ","_key":"199d88582b021"},{"_type":"span","marks":["be20592ef34a","em"],"text":"The New England Journal of Medicine","_key":"199d88582b022"},{"_type":"span","marks":[],"text":".","_key":"199d88582b023"}],"_type":"block","style":"normal","_key":"562e5c4f33c1","markDefs":[{"_key":"be20592ef34a","nofollow":true,"blank":true,"_type":"link","href":"https://www.nejm.org/doi/10.1056/NEJMoa2209813"}]},{"children":[{"_key":"f1f5338e0af00","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"8aa43afedb68","markDefs":[]},{"_key":"fd7182b76145","markDefs":[],"children":[{"text":"That confirmatory trial was completed at over 20 centers in the United States, Australia, and Europe. It enrolled 79 patients; it included patients with stage II to stage IV resectable cutaneous squamous cell carcinoma. One important difference with this study, from the pilot trial, is that it allowed for smaller surgery as patients responded to immunotherapy.","_key":"5fa9be2cca000","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"8e4e70792d0a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Patients in this study were allowed to have less-invasive surgery if it was oncologically appropriate. Surgeons were still required, and encouraged, to remove all gross tumor, but if they felt safe, they could preserve functionally important structures. We had several patients in the trial where that was the case. We highlighted 2 patients in the manuscript who were recommended for up-front orbital exenteration as part of their surgery and planned adjuvant radiation. In both cases, they had a partial response on imaging, but a complete pathologic response at the time of surgery, sparing the eye, and then have gone on to follow up. So very, very encouraging results.","_key":"2aea43284c34"}]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"e2a1d1edf4e30","_type":"span"}],"_type":"block","style":"normal","_key":"495185b83fb1"},{"children":[{"_type":"span","marks":[],"text":"And in the multicenter trial, we confirmed what we saw in the pilot trial, which is that over half of the patients had a complete pathologic response—no residual viable tumor—when it came time for surgery, and another 10 patients out of 79 had a near complete pathologic response. So less than 10% residual viable tumor cells in the specimens. 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She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal","_key":"643be033259e"},{"markDefs":[{"_key":"159c764717fb","nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/maggielshaw/"}],"children":[{"marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on ","_key":"8e1abe71bcd2","_type":"span"},{"marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1","_type":"span"},{"_key":"abc0e18a29ce2","_type":"span","marks":[],"text":"."}],"_type":"block","style":"normal","_key":"f4070c315fab"}],"profileImage":{"_type":"mainImage","alt":"Maggie L. Shaw","asset":{"_ref":"image-7219c501186d8cbe6d25614b5b22645ea1c6fe2c-600x619-jpg","_type":"reference"}},"_updatedAt":"2024-08-07T15:47:36Z","url":{"current":"maggie-l-shaw","_type":"slug"},"displayName":"Maggie L. 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I would never want to start any type of immunomodulatory/inhibitor type of medicine on a transplant patient without talking to the rest of the patient's transplant team. I wouldn't totally rule it out, but there's definitely literature out there that the transplant doctors and transplant pharmacists are very much aware of: that these immune inhibitors do lead to increased graft rejection, rejection of that transplanted organ. And patients don't want that, and of course neither do any of us as doctors.","_key":"3670369182fe0"}],"_type":"block","style":"normal","_key":"38f0a54effc6"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"bdde47404a290","_type":"span"}],"_type":"block","style":"normal","_key":"206673895974"},{"_key":"202a47de42c9","markDefs":[{"blank":true,"_type":"link","href":"https://pubmed.ncbi.nlm.nih.gov/31302190/","_key":"c267d0340a7b"}],"children":[{"_key":"debe57e232400","_type":"span","marks":[],"text":"There's "},{"_type":"span","marks":["c267d0340a7b"],"text":"a recent study","_key":"debe57e232401"},{"_key":"debe57e232402","_type":"span","marks":[],"text":" in "},{"_type":"span","marks":["em"],"text":"Journal of the American Academy of Dermatology","_key":"debe57e232403"},{"text":", a nice analysis of what's in the literature so far, using things like checkpoint inhibitors in transplant patients. And they did show that this is a real concern, that the transplanted organ can be rejected and fail when you're put on a checkpoint inhibitor, or ipilimumab. There was about a 40% chance of that kind of rejection of the organ, and 14% of those patients did die from rejection, losing that key organ.","_key":"debe57e232404","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_key":"820afd6d145b0","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"ff5e5d9a0211","markDefs":[]},{"_type":"block","style":"normal","_key":"7b6fac62606e","markDefs":[],"children":[{"marks":[],"text":"Another thing to keep in mind is that some of these cancers are quite advanced, and the majority of the patients treated with those medicines, you can get a sense that it was an attempt to really control the cancer, because the majority of the patients who died in that analysis died from the cancer, not from graft rejection.","_key":"4b3797457e020","_type":"span"}]},{"_type":"block","style":"normal","_key":"4689c8faec79","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ad9eed4d63950"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think sometimes in medicine we have these really tough decisions to make. I wouldn't say that you can't use those medicines—I have not had to use a medicine like that for skin cancer—but some of the patients certainly do have internal malignancies as well that can be quite advanced. It's something that just needs good communication among a really great team of doctors and, the most important, also patient input.","_key":"7110a584312c0"}],"_type":"block","style":"normal","_key":"df9e23d9a449"},{"children":[{"_key":"e090884c30430","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"0199a30e8a67","markDefs":[]}],"is_visible":true,"contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"factCheckAuthorMapping":null},{"summary":"Todd Schlesinger, MD, FAAD, director, Dermatology and Laser Center of Charleston and Clinical Research Center of the Carolinas, explains the process of Mohs surgery for removing skin cancers and preserving healthy surrounding tissue.","taxonomyMapping":[{"perKeywordMapping":["Dermatologic Cancer","Health Equity Diversity \u0026 Inclusion"],"cmeType":"per","_rev":"rs7eCk0lrr8LMiZP9GDe39","_updatedAt":"2023-11-03T18:21:43Z","summary":[{"style":"normal","_key":"af6b6692093c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"b2ad2a1380d10"},{"_type":"span","marks":["em"],"text":"AJMC® ","_key":"b2ad2a1380d11"},{"marks":[],"text":"Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.","_key":"b2ad2a1380d12","_type":"span"}],"_type":"block"}],"identifier":"skincancer","parent":{"_ref":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_type":"reference"},"_createdAt":"2021-03-25T18:46:14Z","_type":"taxonomy","name":"Skin Cancer","_id":"6630cdc5-805f-485c-89b0-cc7dc33596ea"},{"_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z","identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News"},{"identifier":"interviews","sortOrder":3,"_type":"taxonomy","_createdAt":"2020-03-30T19:16:54Z","_rev":"xqhc4WIQcOa1P2rns6bqkh","name":"Interviews","_id":"2d909731-8acf-4e3d-8962-d59b0da85320","_updatedAt":"2023-10-30T17:48:32Z"}],"_type":"article","_id":"dc35e795-f0d2-4fea-984f-1d7255b8646f","published":"2021-09-28T14:30:57.429Z","title":"Dr Todd Schlesinger: Tissue-Sparing Mohs Surgery Is Highly Accurate","_createdAt":"2021-09-28T13:55:39Z","ExcludeFromHomePage":false,"is_visible":true,"authorMapping":[{"_createdAt":"2020-05-05T10:50:09Z","_rev":"4vyIlJfwMwqB8NbLEufdwW","_type":"author","_id":"author_51b2956e2bd42e0d6e35a66971fd60bc","biography":[{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Maggie is an editor for The American Journal of Managed Care® (AJMC®) and produces written, video, and podcast content covering several disease states. 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Mohs surgery has a set of appropriate-use criteria, and most dermatologists will be aware of those criteria. In a nutshell, we're talking tumors that are in sensitive areas of the body: the central part of the face, the ears, the temples, the scalp, the nose, the lips, fingers, genital areas, things like that. We're looking where we want to spare tissue, and we want to remove the cancer with the smallest amount of normal skin around it.","_key":"ca0af5855c5c0","_type":"span"}],"_type":"block","style":"normal"},{"_key":"434248094d74","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The other big important piece of Mohs surgery is the way that pathology slides are processed. The key is that they're processed so that way 100% of the surgical margin is examined in 1 plane. As you slice through the specimen, you can see all the way around the edges and you can see the center at the same time—that’s what you see when you do the first layer of Mohs. This is a micrographic, highly controlled type of surgery with a high cure rate.","_key":"796cce66571b0"}],"_type":"block","style":"normal"},{"_key":"2a2874a35db0","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The other important point is that the surgeon is also the pathologist, so the same person is removing the tissue and seeing what's going on clinically with a patient and the tumor bed. They're also reading the slides and comparing those, too, and that comparison that's done by that 1 person improves the accuracy tremendously over traditional surgery.","_key":"f2a203da7dc90"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Mohs surgery is a highly accurate, microscopically controlled surgery that can help our patients get clear of tumors with the lowest chance of recurrence.","_key":"ea3d9a8091f90"}],"_type":"block","style":"normal","_key":"28d87aa945d9"}],"contentCategory":{"_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z"},"internalTag":["Mohs surgery","normal skin","scalp, temples","genital areas","pathology slides ","micrographic","microscopically controlled"],"url":{"current":"dr-todd-schlesinger-tissue-sparing-mohs-surgery-is-highly-accurate","_type":"slug"},"updatedOn":null},{"_id":"f760c349-d2bb-439c-86e4-52d7e9d0cd85","is_visible":true,"url":{"_type":"slug","current":"dr-christine-ko-transplant-patients-face-unique-skin-cancer-risks"},"summary":"Patients who undergo transplant face an increased risk of skin cancer because of their immunosuppressed status, explained Christine Ko, MD, professor of dermatology and pathology at Yale University.\n","link":"/view/dr-christine-ko-transplant-patients-face-unique-skin-cancer-risks","updatedOn":null,"internalTag":["skin cancer","transplant patients","orgran rejection","immunosuppressed status","dermatopathology","azathioprine","calcineurin inhibitors","ultraviolet light–induced mutations","genetic code"],"body":[{"source":"brightcove","_key":"92e352661f54","_type":"video","videoID":"6271749720001"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Patients who undergo transplant face an increased risk of skin cancer because of their immunosuppressed status, notably from the medicines they are on to prevent organ rejection, some of which can cause DNA mutations, explained Christine Ko, MD, professor of dermatology and pathology at Yale University.","_key":"1fe51b6dceae"}],"_type":"block","style":"normal","_key":"9a74bcfec193"},{"_key":"ff9db556c00e","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"b0ef4f1cdc4f0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":["strong"],"text":"What factors predispose transplant patients to a higher risk of skin cancers?","_key":"03d6046981ab0","_type":"span"}],"_type":"block","style":"normal","_key":"f5da35261608"},{"markDefs":[],"children":[{"text":"So I enjoy transplant dermatology because I've been interested for a long time in skin cancer. One of the more common skin cancers they get is reported to be squamous cell carcinoma, which has been a long-standing interest of mine, initially more from the dermatopathology side. So these types of patients, some people are surprised. Some of my friends are like, “Why are you seeing transplant patients?” I reply, “Well, I just look at their skin.” The reason they're at increased risk for skin cancer is because of the immunosuppressive medicines they're on to prevent rejection of the transplanted organ. The great thing is, medicine is continuing to evolve and some of the newer immunosuppressive medicines that they're put on are not as promoting of skin cancer.","_key":"8a8347fb30e90","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"e3b280078e8f"},{"_type":"block","style":"normal","_key":"0c7ace5f92aa","markDefs":[],"children":[{"marks":[],"text":"So that's great, but for example, azathioprine used to be used more, and that can directly cause mutations in our genetic code, in our DNA. And that's not good. There's a relationship also with sun exposure and sun damage; sun also being able to cause ultraviolet light–induced mutations. And so anything that can sort of add on to that is not good, and azathioprine can do that.","_key":"7fc603bd5b660","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Cyclosporine and tacrolimus are other medicines that are used more often now, compared to azathioprine, and they're both in a class called calcineurin inhibitors. Those medicines don't directly cause DNA damage—like kind of inserting themselves into the DNA the way that azathioprine does—so that's good. But both of those also have strong immunosuppressive effects, which transplant doctors want for the sake and the patient wants too for the sake of their transplanted organ, but [they] can reduce immune surveillance, which is important for preventing skin cancer, particularly in sun-damaged skin of these patients who sometimes have very light skin and a significant amount of sun exposure from the past.","_key":"750862614ac40"}],"_type":"block","style":"normal","_key":"d465b0401c07"}],"source":null,"factCheckAuthorMapping":null,"thumbnail":{"asset":{"extension":"jpg","url":"https://cdn.sanity.io/images/0vv8moc6/ajmc/c8036a2f8d2f2556835dd05e6380691ead28ee3d-1280x720.jpg","_updatedAt":"2021-04-18T13:08:05Z","originalFilename":"Ko TN9.jpg","uploadId":"pTW4LEQyyDxoBnIQuIc74Yk0Hi6pyJjf","_id":"image-c8036a2f8d2f2556835dd05e6380691ead28ee3d-1280x720-jpg","_rev":"g4B6uv27sZb3vM8Dw5ZWKE","path":"images/0vv8moc6/ajmc/c8036a2f8d2f2556835dd05e6380691ead28ee3d-1280x720.jpg","size":134322,"assetId":"c8036a2f8d2f2556835dd05e6380691ead28ee3d","metadata":{"palette":{"lightMuted":{"foreground":"#000","title":"#fff","population":7.04,"background":"#c7a89e","_type":"sanity.imagePaletteSwatch"},"vibrant":{"title":"#fff","population":0.36,"background":"#7e1d34","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"dominant":{"background":"#c7a89e","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":7.04},"_type":"sanity.imagePalette","darkMuted":{"foreground":"#fff","title":"#fff","population":2.49,"background":"#4c392e","_type":"sanity.imagePaletteSwatch"},"muted":{"title":"#fff","population":1.22,"background":"#a07969","_type":"sanity.imagePaletteSwatch","foreground":"#fff"},"lightVibrant":{"background":"#dcc49c","_type":"sanity.imagePaletteSwatch","foreground":"#000","title":"#fff","population":0},"darkVibrant":{"background":"#14246c","_type":"sanity.imagePaletteSwatch","foreground":"#fff","title":"#fff","population":0}},"hasAlpha":false,"lqip":"data:image/jpeg;base64,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","dimensions":{"_type":"sanity.imageDimensions","width":1280,"aspectRatio":1.7777777777777777,"height":720},"isOpaque":true,"_type":"sanity.imageMetadata"},"_type":"sanity.imageAsset","mimeType":"image/jpeg","sha1hash":"c8036a2f8d2f2556835dd05e6380691ead28ee3d","_createdAt":"2021-04-18T13:08:05Z"}},"_rev":"X5BLXvIsQK0op5bUQGHwuB","_type":"article","authorMapping":[{"profileImage":{"_type":"mainImage","alt":"Maggie L. 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Our medical patients oftentimes become research patients; our research patients become medical patients; both sides end up being cosmetic patients. I think it's a continuum. For example, if someone has skin cancer, they may end up either having ","_key":"0162c10b64a20","_type":"span"},{"text":"Mohs","_key":"0162c10b64a21","_type":"span","marks":["caaa49eb98bb"]},{"_type":"span","marks":[],"text":" surgery or excisional surgery or whatnot. They may end up also in a study, after a surgery. They may end up going to the cosmetic area to have laser treatment, a follow-up to treat the scar to make that look nicer. It really all runs together.","_key":"0162c10b64a22"}],"_type":"block","style":"normal","_key":"90ce87d1f604"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"dbc87bf008b50"}],"_type":"block","style":"normal","_key":"f814529fd464"},{"children":[{"_type":"span","marks":[],"text":"I think having ","_key":"4e2e723afa340"},{"marks":["d5965365190c"],"text":"a practice","_key":"4e2e723afa341","_type":"span"},{"_type":"span","marks":[],"text":" that has the different components and sort of being a full-service practice for a patient kind of makes their lives easier as well. I think the research side of its unique and that we can offer something to those patients that may not have any other options, who are maybe looking for other options, maybe they're uninsured and they don't have treatment options that other patients might have, or they just are very interested in learning and how they can help other patients by participating in the trial.","_key":"4e2e723afa342"}],"_type":"block","style":"normal","_key":"a52f1d072df6","markDefs":[{"blank":true,"_type":"link","href":"https://dermandlaser.com/","_key":"d5965365190c"}]},{"_type":"block","style":"normal","_key":"566368b0fb6f","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"791d7ad3481c0"}]},{"style":"normal","_key":"c20d7a594b8a","markDefs":[],"children":[{"marks":[],"text":"So there's lots of reasons why patients sort of move between one part of the practice and another, but it's very comforting, I think, to be able to have all the components in one place.","_key":"f1608072451e0","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"81f6666796d80"}],"_type":"block","style":"normal","_key":"f06090ef51c4"},{"_type":"block","style":"normal","_key":"783ae65bf907","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How has the treatment of patients with advanced skin cancers changed over the years?","_key":"394a1f2126be0"}]},{"_type":"block","style":"normal","_key":"44e34d7d5258","markDefs":[],"children":[{"_key":"b714ab7758720","_type":"span","marks":[],"text":""}]},{"style":"normal","_key":"e7d45ec14071","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So this treatment of skin cancer has changed significantly over the past several years, primarily in the past 5 years, and some of the top developments in the treatment of these skin cancers have been the medical treatments. We've had Mohs surgery around for a number of years now, and it has undergone a slow advance and is doing very well in treating our patients that have tumors that are candidates for Mohs surgery. But for those patients who are not surgical candidates or maybe not radiation therapy candidates, for various reasons, we now have medical treatments for advanced skin cancer. And that's really where most of the innovation has come.","_key":"53b27f4523e20"}],"_type":"block"},{"_type":"block","style":"normal","_key":"28c3e779fddb","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9b88d76690ca0"}]},{"_key":"369da9e12253","markDefs":[],"children":[{"marks":[],"text":"A few years ago, we really didn't have any approved therapies for squamous cell carcinoma that was locally advanced or metastatic, and now we have 2 treatments, 2 immunotherapy medications that are approved. So that's been a paradigm shift from what we call traditional cytotoxic chemotherapy. Think paclitaxel and radiation, epidermal growth factor receptor inhibitors, think cetuximab medications—things like that were used to treat squamous cell carcinoma that was cutaneous in origin but never approved. So I think the approval of immunotherapy has been a big advance.","_key":"e00960c3a8840","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"4bd2d933d3d30"}],"_type":"block","style":"normal","_key":"7a131c8731e6","markDefs":[]},{"_key":"5437dda9f77b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The increased experience that we have with the hedgehog pathway–inhibiting medications is also an advance. So hopefully we'll continue to see a targeted approach to the treatment of skin cancer, with new developments and new research that is looking to enhance the benefits and the outcomes of immunotherapy, looking to treat the patients that are maybe resistant to those therapies that aren't responding or for whatever reason are maybe progressing on those therapies.","_key":"c423f01c5c200"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"94a1bffff1090","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"9655d41e74e4"}],"title":"Dr Todd Schlesinger on How Medical, Cosmetic, Research Dermatology Interact","internalTag":["skin cancer","reserach dermatology","medical patients","research patients","Schlesinger","Mohs surgery","innovation"],"updatedOn":null,"_createdAt":"2021-08-31T14:34:39Z","_id":"c27cc17d-df5b-4ba7-ad08-5b4665ca99d7","taxonomyMapping":[{"perKeywordMapping":["Dermatologic Cancer","Health Equity Diversity \u0026 Inclusion"],"cmeType":"per","_rev":"rs7eCk0lrr8LMiZP9GDe39","_updatedAt":"2023-11-03T18:21:43Z","summary":[{"_key":"af6b6692093c","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The ","_key":"b2ad2a1380d10"},{"_type":"span","marks":["em"],"text":"AJMC® ","_key":"b2ad2a1380d11"},{"marks":[],"text":"Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.","_key":"b2ad2a1380d12","_type":"span"}],"_type":"block","style":"normal"}],"identifier":"skincancer","parent":{"_ref":"297fa3d1-5216-46eb-bf51-66c5f77c3c8a","_type":"reference"},"_createdAt":"2021-03-25T18:46:14Z","_type":"taxonomy","name":"Skin Cancer","_id":"6630cdc5-805f-485c-89b0-cc7dc33596ea"},{"_createdAt":"2020-03-30T18:05:45Z","_rev":"OU32WOWh4YetHW0RkWbkso","_type":"taxonomy","name":"News","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","_updatedAt":"2022-01-19T10:20:16Z","identifier":"news"},{"_createdAt":"2020-03-30T19:16:54Z","_rev":"xqhc4WIQcOa1P2rns6bqkh","name":"Interviews","_id":"2d909731-8acf-4e3d-8962-d59b0da85320","_updatedAt":"2023-10-30T17:48:32Z","identifier":"interviews","sortOrder":3,"_type":"taxonomy"},{"name":"Browse Videos","_id":"7701725f-7550-4170-9bd5-217ccfb9e403","_updatedAt":"2021-01-11T17:33:53Z","identifier":"browse-videos","_createdAt":"2021-01-11T17:17:07Z","_rev":"9Hk29MwXotQfwan9hSYfpg","_type":"taxonomy"}],"source":null,"factCheckAuthorMapping":null,"url":{"current":"dr-todd-schlesinger-on-how-medical-cosmetic-research-dermatology-interact","_type":"slug"},"link":"/view/dr-todd-schlesinger-on-how-medical-cosmetic-research-dermatology-interact","_rev":"4Mv5qiEHvXhTLQxvsfra5C","published":"2021-09-05T12:00:00.000Z","_type":"article","contentCategory":{"_type":"contentCategory","name":"Videos","_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB"},"_updatedAt":"2021-09-28T14:00:29Z","summary":"Being a full-service dermatology practice helps make patients' lives easier when they have skin cancer, explained Todd Schlesinger, MD, FAAD, director, Dermatology and Laser Center of Charleston and Clinical Research Center of the Carolinas.\n","is_visible":true,"authorMapping":[{"profileImage":{"_type":"mainImage","alt":"Maggie L. 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Todd Schlesinger: Morphology, Immunosuppression Affect Actinic Keratosis Outcomes","_updatedAt":"2021-08-17T20:19:27Z","link":"/view/dr-todd-schlesinger-morphology-immunosuppression-affect-actinic-keratosis-outcomes","factCheckAuthorMapping":null,"summary":"Actinic keratosis outcomes can be affected by several variables, and these lesions need to be treated to minimize progression risk, noted Todd Schlesinger, MD, FAAD, director, Dermatology and Laser Center of Charleston and Clinical Research Center of the Carolinas.","_id":"cbab084b-848d-4081-a9c5-9a9a22e0dc62","internalTag":["skin cancer"],"source":null,"published":"2021-08-19T12:00:00.000Z","body":[{"markDefs":[],"children":[{"text":"","_key":"163c2d0ec86e","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"81654842d4bd"},{"_type":"video","videoID":"6268170608001","source":"brightcove","_key":"4085155fc9e3"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Actinic keratosis outcomes can be affected by several variables, including chronic sun exposure, mutational burden, and immunosuppression. These concerning lesions need to be treated to minimize progression risk, noted Todd Schlesinger, MD, FAAD, director, Dermatology and Laser Center of Charleston and Clinical Research Center of the Carolinas.","_key":"fb5f674edf110"}],"_type":"block","style":"normal","_key":"8cbbfdf83664"},{"_key":"46da4aa2a644","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9799051e60800"}],"_type":"block","style":"normal"},{"style":"normal","_key":"ec951ebdac84","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"afc06b7134920"}],"_type":"block"},{"markDefs":[],"children":[{"_key":"134b14b3b0af0","_type":"span","marks":["strong"],"text":"Why do 10% of patients with actinic keratosis develop skin cancer?"}],"_type":"block","style":"normal","_key":"592bece9d6d1"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"0000076d0fa90"}],"_type":"block","style":"normal","_key":"a9841a11fb3c"},{"_key":"834db42ebd0c","markDefs":[],"children":[{"text":"I think to reverse that question. If you're gonna say close to 90% of patients with actinic keratosis don't develop skin cancers, the other 10% do, or approximately. So, actinic keratoses are small keratotic lesions that develop typically on skin that has been chronically exposed to the sun—occurs a little more in our subpopulation that are older, more Caucasian, more males than females. These are lesions that are concerning, and they all should be treated to minimize the risk of progression. That's the main concern.","_key":"9cf711bf8ef30","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"style":"normal","_key":"d59883a35d17","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5c2a5fa408cc0"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"As far as who develops skin cancer and who doesn't, I think one thing that can be argued is that the amount of sun exposure someone's had over a lifetime can affect that. But since actinic keratoses and squamous cell carcinomas are tumors that rely on their mutational burden to develop tumors, which means a number of mutations or the types of mutations that are present—such as ","_key":"0176cf92c9fa0"},{"_type":"span","marks":["em"],"text":"p53 ","_key":"0176cf92c9fa1"},{"_type":"span","marks":[],"text":"or ","_key":"0176cf92c9fa2"},{"_type":"span","marks":["em"],"text":"Notch","_key":"0176cf92c9fa3"},{"_type":"span","marks":[],"text":" mutations—in these tumors sort of determine what direction they're going to go in.","_key":"0176cf92c9fa4"}],"_type":"block","style":"normal","_key":"712d61f697f8","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"790e8681d3b00","_type":"span"}],"_type":"block","style":"normal","_key":"d1965cddb4c9"},{"_type":"block","style":"normal","_key":"7655086fc73a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"So I think more often than not it’s the morphology of the individual lesion that helps decide whether it's going to go toward cancer, and also the patient's level of immunosuppression. A patient who may be older, or may be on immunosuppressive therapy of one kind or another, may be a solid organ transplant recipient or other transplant, might have a higher risk as well. So I think it's a complex interplay between the tumor cells, the pending tumor cells in actinic keratosis, and the patient's immune response.","_key":"154f848461af0"}]}],"_type":"article","authorMapping":[{"_type":"author","_id":"author_51b2956e2bd42e0d6e35a66971fd60bc","biography":[{"children":[{"_type":"span","marks":[],"text":"Maggie is an editor for The American Journal of Managed Care® (AJMC®) and produces written, video, and podcast content covering several disease states. She joined AJMC® in 2019, and has been with AJMC®’s parent company, MJH Life Sciences®, since 2014, when she started as a copy editor.","_key":"abc0e18a29ce0"}],"_type":"block","style":"normal","_key":"643be033259e","markDefs":[]},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.linkedin.com/in/maggielshaw/","_key":"159c764717fb"}],"children":[{"marks":[],"text":"She has a BA in English from Penn State University. You can connect with Maggie on ","_key":"8e1abe71bcd2","_type":"span"},{"marks":["159c764717fb"],"text":"LinkedIn","_key":"abc0e18a29ce1","_type":"span"},{"_key":"abc0e18a29ce2","_type":"span","marks":[],"text":"."}],"_type":"block","style":"normal","_key":"f4070c315fab"}],"profileImage":{"_type":"mainImage","alt":"Maggie L. Shaw","asset":{"_ref":"image-7219c501186d8cbe6d25614b5b22645ea1c6fe2c-600x619-jpg","_type":"reference"}},"_updatedAt":"2024-08-07T15:47:36Z","url":{"current":"maggie-l-shaw","_type":"slug"},"displayName":"Maggie L. 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