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/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75 3840w" src="/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2F0vv8moc6%2Fajmc%2F11ee9be36fc4be88ca66a17e7b37ebc45bb91d87-6048x4024.jpg%3Ffit%3Dcrop%26auto%3Dformat&w=3840&q=75" decoding="async" data-nimg="fill" style="position:absolute;top:0;left:0;bottom:0;right:0;box-sizing:border-box;padding:0;border:none;margin:auto;display:block;width:0;height:0;min-width:100%;max-width:100%;min-height:100%;max-height:100%" class="object-contain" loading="lazy"/></noscript></span></a></div><div class="border-t-gray-100 border-t-2 flex-auto py-2 "><span class="text-sm text-gray-500 py-2">February 13th 2025</span><div class="py-3"><a class="lg:text-[20px] text-[19px] font-[500]" href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm">Rapid IV Isatuximab Could Shift Care Practices in MM</a></div><div class="pb-2"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/kyle-munz"><i>Kyle Munz</i></a></span></div></div><a href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm"><a href="/view/rapid-iv-isatuximab-could-shift-care-practices-in-mm"><p class="mt-1 text-gray-800 text-[13px] line-clamp-6 text-hidden">Reducing intravenous (IV) isatuximab delivery from 75 minutes to 30 minutes could provide a wealth of benefits to patients with multiple myeloma (MM) and health care systems alike. </p></a></a></div></div><div class="flex-wrap w-[60%] flex "><a class="flex w-[50%] flex-col sm:pl-[35px] pl-[20px] pb-[35px] " href="/view/prolonged-survival-in-mm-insights-from-the-largest-ongoing-us-registry"><div class="w-full lg:h-[134px] h-[100px] relative bg-default-logo-background "><span 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loading="lazy"/></noscript></span></div><div class="jsx-1215160397 content-wrap"><span class="jsx-1215160397 py-3 text-sm text-gray-500 text-left"><i class="jsx-1215160397">February 13th 2025</i></span><div class="jsx-1215160397 w-full h-fit mb-4"><p class="jsx-1215160397 text-[18px] font-bold text-[#000000] text-left line-clamp-3 text-hidden">Rapid IV Isatuximab Could Shift Care Practices in MM</p></div><div class="jsx-1215160397 pb-2 text-left ]"><div><span class="text-md "><span class="mr-1 italic">By </span><a class="mr-1 text-sky-800 hover:text-primary" href="/authors/kyle-munz"><i>Kyle Munz</i></a></span></div></div></div></div></a><a target="" style="scroll-snap-align:center;text-decoration:none" class="jsx-1637274924 sm:w-[280px] xs:w-[240px] w-[65%] h-auto flex flex-col space-y-3 flex-none select-none no-underline" href="/view/prolonged-survival-in-mm-insights-from-the-largest-ongoing-us-registry"><div class="jsx-1637274924 w-full h-full flex flex-col overflow-hidden relative 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src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a60f150e189372245ee049cd9c2e6415ca9d36dd-4368x2448.jpg?fit=crop&auto=format" alt="MRD status cannot be detected with a microscope and is achieved through bone marrow analysis | image credit: Arthur Constantine - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 13th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mrd-negativity-a-robust-predictor-of-survival-outcomes-in-mm">MRD Negativity: A "Robust" Predictor of Survival Outcomes in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mrd-negativity-a-robust-predictor-of-survival-outcomes-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This meta-analysis sheds more light on the beneficial impact of multiple melanoma (MM) treatments and the predictive value of minimal residual disease (MRD) status for patient prognoses. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/subcutaneous-isatuximab-meets-primary-end-points-in-phase-3-study-for-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/2504049076ad7024f0aa5829e17f3167ed294686-300x300.jpg?fit=crop&auto=format" alt="Woman wearing Enfuse injector | image credit: Enable Injections" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 9th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/subcutaneous-isatuximab-meets-primary-end-points-in-phase-3-study-for-mm">Subcutaneous Isatuximab Meets Primary End Points in Phase 3 Study for MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/mary-caffrey">Mary Caffrey</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/subcutaneous-isatuximab-meets-primary-end-points-in-phase-3-study-for-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If the subcutaneous delivery method gains approval, an advantage daratumumab holds over isatuximab would be removed.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4ec4991c20fca48bd4a94346024fe8978ca29f9b-5496x3664.jpg?fit=crop&auto=format" alt="mRNA vaccines can boost T cell responses | image credit: myskin - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">January 9th 2025</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm">Study Advocates Immunological Value of COVID-19 Vaccination in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/study-advocates-immunological-value-of-covid-vaccination-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients with multiple myeloma (MM) can experience diminished immune responses during prolonged treatment; however, mRNA vaccines could bolster immunity in this vulnerable population. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3474531227ec6ae0ecdb2a913a4204946efd75a5-3187x1625.png?fit=crop&auto=format" alt="ASH thumbnail" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024">ICYMI: Highlights From ASH 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ash-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The 66th American Society of Hematology (ASH) Annual Meeting & Exposition took place December 7-10, 2024, in San Diego, California; the 2025 meeting is currently scheduled to take place in Orlando, Florida, December 6-9.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/ef6f1663f0b22e324047ab01ad49bda91c402dd8-3187x1625.png?fit=crop&auto=format" alt="MM Top 5 Thumbnail" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024">Top 5 Multiple Myeloma Content of 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/top-5-multiple-myeloma-content-of-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Through interviews and articles infused with expert insight, progress against this cancer that develops in the bone marrow was showcased. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/113dcf7dd1ba47890eba652e443c1fa23a50ac28-3187x1625.png?fit=crop&auto=format" alt="ICYMI: Highlights From IMS 2024 " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024">ICYMI: Highlights From IMS 2024 </a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-ims-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The expert knowledge presented at this year’s International Myeloma Society (IMS) annual meeting focused on minimal residual disease testing and status, defining and treating high-risk disease, CEPHEUS trial findings, and an investigational off-the-shelf chimeric antigen receptor T-cell therapy.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-7"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-eha-2024"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/107764a53f215059fe82c396b3cdd6f74ece52e4-3187x1625.png?fit=crop&auto=format" alt="EHA Highlights thumbnail" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">December 5th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-eha-2024">ICYMI: Highlights From EHA 2024</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/icymi-highlights-from-eha-2024"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Presentations at the European Hematology Association (EHA) 2024 Congress were encouraging for their data on innovations within the hematology/oncology space that are reshaping treatment outcomes.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/124e5227038c54b0c2ef35d60292e6f37e89161a-1200x738.jpg?fit=crop&auto=format" alt="Guidelines | Image Credit: © momius-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma">NCCN Guidelines Prioritize Quad Therapy in Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/nccn-guidelines-prioritize-quad-therapy-in-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In the most recent update to the National Comprehensive Cancer Network (NCCN) guidelines for treating patients who have multiple myeloma, a quadruplet regimen became the preferred first-line treatment option for transplant-eligible and -ineligible patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6c4eacfe9c992d1f7ea48bbb7606ade7b9a0b9cf-1920x1080.jpg?fit=crop&auto=format" alt="Don M. Benson, MD, PhD, James Cancer Hospital" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 22nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach">Balancing Life and Myeloma: A Patient-Centered Approach</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/balancing-life-and-myeloma-a-patient-centered-approach"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In this second part of our discussion with Don M. Benson, MD, PhD, from our recent Institute for Value-Based Medicine® event in Cleveland, Ohio, he explains how his ultimate goal for his patients is for them to live as long and as well as possible.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/c93bf646d31467af3bf1146ded1ddb1b32755d08-2022x645.png?fit=crop&auto=format" alt="Elevating Value in Cancer Care With Innovations, Accessibility, Equity" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity">Elevating Value in Cancer Care With Innovations, Accessibility, Equity</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-value-in-cancer-care-with-innovations-accessibility-equity"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Coverage from the IVBM Regional event in Denver, Colorado.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/80e6c85b19f91f7e54b4708b48cf74f795adc108-1200x738.jpg?fit=crop&auto=format" alt="Multiple Myeloma | Image Credit: © Dzmitry-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 19th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm">OS Better With Belantamab Mafodotin Triplet vs Daratumumab in R/R MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/jordyn-sava">Jordyn Sava</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/os-better-with-belantamab-mafodotin-triplet-vs-daratumumab-in-r-r-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The key secondary end point of overall survival (OS) was met in the DREAMM-7 trial of belantamab mafodotin (Blenrep; GSK) for the treatment of patients with relapsed/refractory multiple myeloma (R/R MM).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/elevating-myeloma-care-amidst-complex-treatment-choices"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/9b9874b28b21d52d6b1aa78689e72d7eb07fb979-1200x677.jpg?fit=crop&auto=format" alt="Don M. Benson, MD, PhD, James Cancer Hospital" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/elevating-myeloma-care-amidst-complex-treatment-choices">Elevating Myeloma Care Amidst Complex Treatment Choices</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/elevating-myeloma-care-amidst-complex-treatment-choices"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Don M. Benson, MD, PhD, has cared for patients at James Cancer Hospital in Ohio for 22 years, where he and his team see approximately 10,000 patient visits each year.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-13"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/eque-cel-car-t-shows-strong-results-for-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d6cda65715e52774e2cab34d922cdd302167b243-1200x738.jpg?fit=crop&auto=format" alt="Neon CAR T graphic | Image Credit: © kalpis-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 7th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/eque-cel-car-t-shows-strong-results-for-multiple-myeloma">Eque-Cel CAR T Shows Strong Results for Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/eque-cel-car-t-shows-strong-results-for-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Multiple myeloma is the second most common hematologic malignancy, but there is a treatment gap for patients with disease progression following standard-of-care therapies that include immunomodulatory agents, proteasome inhibitors, and anti-CD38 antibodies.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/making-cancer-care-easier-with-community-bispecific-antibody-programs"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4edd101225fd12036d64c1d3622149d3bddcd243-1280x719.png?fit=crop&auto=format" alt="Screenshot of an interview with Courtney VanHouzen, PharmD" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 15th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/making-cancer-care-easier-with-community-bispecific-antibody-programs">Making Cancer Care Easier With Community Bispecific Antibody Programs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/alexandra-gerlach">Alexandra Gerlach</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/laura-joszt">Laura Joszt, MA</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/making-cancer-care-easier-with-community-bispecific-antibody-programs"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Allowing patients to stay in their homes to receive bispecific antibodies can make the whole cancer journey easier, explained Courtney VanHouzen, PharmD, of Cowell Family Cancer Center, Munson Healthcare.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/miles-matter-the-geographic-disparity-that-impacts-access-to-car-t-therapy"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/3d97f41753d5036fe06a27339f606f5bb4fd9d8f-2400x1600.jpg?fit=crop&auto=format" alt="Thomas Jefferson | Image: Thomas Jefferson University " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 13th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/miles-matter-the-geographic-disparity-that-impacts-access-to-car-t-therapy">Miles Matter: The Geographic Disparity That Impacts Access to CAR T Therapy</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/ryan-flinn">Ryan Flinn</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/miles-matter-the-geographic-disparity-that-impacts-access-to-car-t-therapy"></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/delays-in-myeloma-oral-therapy-linked-to-race-age"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/75a045d91321b8483c43f41bf052203a0cb3f568-4397x3412.jpg?fit=crop&auto=format" alt="Health disparities word cloud | Image Credit: Colored Lights-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 11th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/delays-in-myeloma-oral-therapy-linked-to-race-age">Delays in Myeloma Oral Therapy Linked to Race, Age</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/delays-in-myeloma-oral-therapy-linked-to-race-age"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Outcomes of interest in this study were time from diagnosis to initial prescription fill for an oral multiple myeloma (MM) medication and time from initial diagnosis to receipt of any treatment for MM.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/isatuximab-approval-highlights-role-of-anti-cd38-antibody-in-myeloma-care"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/d2d71ee7e41fc353ec8dc2a9dfdc27cc40cb40ac-1200x675.jpg?fit=crop&auto=format" alt="Surbhi Sidana, MD, MBBS, Stanford University" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 2nd 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/isatuximab-approval-highlights-role-of-anti-cd38-antibody-in-myeloma-care">Isatuximab Approval Highlights Role of Anti-CD38 Antibody in Myeloma Care</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/isatuximab-approval-highlights-role-of-anti-cd38-antibody-in-myeloma-care"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">On September 20, the FDA approved isatuximab plus bortezomib, lenalidomide, and dexamethasone in the first line for patients who have multiple myeloma and are ineligible for transplant. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/mrd-as-a-new-paradigm-in-myeloma-treatment"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/790660959e556ef9c9d3b479bb627446ee9ecc80-2864x1634.png?fit=crop&auto=format" alt="Rahul Banerjee, MD, FACP." width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/mrd-as-a-new-paradigm-in-myeloma-treatment">MRD as a New Paradigm in Myeloma Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/cameron-santoro">Cameron Santoro</a><span class="jsx-ad50481d5ee26850 mr-1 ml-[1px]"> </span><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/aislinn-antrim">Aislinn Antrim</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/mrd-as-a-new-paradigm-in-myeloma-treatment"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Rahul Banerjee, MD, FACP, assistant professor in the Division of Hematology and Oncology, at the University of Washington, determines the optimal use of minimal residual disease (MRD) in individual patient management, including decisions about continuing or stopping treatment.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-19"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/varied-types-levels-of-support-needed-for-patients-with-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/7f842239e3b3b2e06a220dac987c201761de64b3-7073x3500.jpg?fit=crop&auto=format" alt="Multiple myeloma | Image credit: freshidea - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/varied-types-levels-of-support-needed-for-patients-with-multiple-myeloma">Varied Types, Levels of Support Needed for Patients With Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/julia-bonavitacola">Julia Bonavitacola</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/varied-types-levels-of-support-needed-for-patients-with-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Information on the disease and treatments, assistance with insurance, and transportation are among the types of support needed by patients with multiple myeloma to improve outcomes and overall burden.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/bridging-global-treatment-gaps-in-relapsed-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cda4a66773ecad35c99e0b776bda873d8dda6f50-1200x675.jpg?fit=crop&auto=format" alt="Leland Metheny, MD, lead investigator for the phase 1 BAFF CAR T clinical trial, University Hospitals Seidman Cancer Center" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 17th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/bridging-global-treatment-gaps-in-relapsed-multiple-myeloma">Bridging Global Treatment Gaps in Relapsed Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/bridging-global-treatment-gaps-in-relapsed-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The principal goal of therapies for multiple myeloma, which remains incurable, is to extend progression-free survival, but challenges remain bringing chimeric antigen receptor T-cell therapy to the world, explains Leland Metheny, MD, lead investigator for the phase 1 BAFF CAR T clinical trial, University Hospitals Seidman Cancer Center.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/d-vrd-boosts-mrd-negativity-in-transplant-eligible-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/e8b89f6523b42f0e4eac2c396f686ac915160fbf-1200x738.jpg?fit=crop&auto=format" alt="Clinical trial results | Image Credit: Egor-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">September 12th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/d-vrd-boosts-mrd-negativity-in-transplant-eligible-multiple-myeloma">D-VRd Boosts MRD Negativity in Transplant-Eligible Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/chris-ryan">Chris Ryan</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/d-vrd-boosts-mrd-negativity-in-transplant-eligible-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approved the quadruplet regimen on July 30 for induction and consolidation therapies in patients with newly diagnoses multiple myeloma who are eligible for autologous stem cell transplant. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/triple-target-car-t-cells-benefits-and-challenges"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cda4a66773ecad35c99e0b776bda873d8dda6f50-1200x675.jpg?fit=crop&auto=format" alt="Leland Metheny, MD, University Hospitals Seidman Cancer Center" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 30th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/triple-target-car-t-cells-benefits-and-challenges">Triple-Target CAR T Cells: Benefits and Challenges</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/triple-target-car-t-cells-benefits-and-challenges"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">In part 1 of our interview with Leland Metheny, MD, he explained how a new triple-target chimeric antigen receptor (CAR) T-cell therapy works in multiple myeloma.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-car-t-trial-in-mm-aims-for-triple-receptor-targeting"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cda4a66773ecad35c99e0b776bda873d8dda6f50-1200x675.jpg?fit=crop&auto=format" alt="Leland Metheny, MD, University Hospitals Seidman Cancer Center " width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 24th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-car-t-trial-in-mm-aims-for-triple-receptor-targeting">New CAR T Trial in MM Aims for Triple Receptor Targeting</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-car-t-trial-in-mm-aims-for-triple-receptor-targeting"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Leland Metheny, MD, is lead investigator for the Phase 1 BAFF CAR T clinical trial, which is evaluating the safety and effectiveness of a novel approach to chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM) that targets 3 receptors on cancer cells and uses electroporation vs the typical lentiviral vector delivery. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-issues-crl-for-linvoseltamab-in-r-r-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/cdc10674fe8a1ccf14048f3b60b2e86e3ffe8bb1-5000x3337.jpg?fit=crop&auto=format" alt="Regeneron logo | Image credit: Casimiro – stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-issues-crl-for-linvoseltamab-in-r-r-multiple-myeloma">FDA Issues CRL for Linvoseltamab in R/R Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/hayden-e-klein">Hayden E. Klein</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-issues-crl-for-linvoseltamab-in-r-r-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The complete response letter (CRL) was issued based on a pre-approval inspection at a third-party fill/finish manufacturer.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-25"></div></div></div><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/second-asct-extends-survival-in-relapsed-multiple-myeloma"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/8caf2ee1f420c7185048fb92441c1b5b881d218a-1200x738.jpg?fit=crop&auto=format" alt="stem cells | Image Credit: jarun011-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 20th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/second-asct-extends-survival-in-relapsed-multiple-myeloma">Second ASCT Extends Survival in Relapsed Multiple Myeloma</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/second-asct-extends-survival-in-relapsed-multiple-myeloma"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">To continue the response they experienced with a first autologous stem‐cell transplant (ASCT) for their multiple myeloma, patients in this analysis received a second ASCT, with French investigators evaluating their outcomes. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/challenges-with-pomalidomide-for-patients-with-comorbid-rrmm-ckd"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/568bbc1591d5d6400d39c9416b6235ce6dfcf018-1200x738.jpg?fit=crop&auto=format" alt="MM treatment | Image Credit: Dzmitry-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 14th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/challenges-with-pomalidomide-for-patients-with-comorbid-rrmm-ckd">Challenges With Pomalidomide for Patients With Comorbid RRMM, CKD</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/challenges-with-pomalidomide-for-patients-with-comorbid-rrmm-ckd"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Patients who have comorbid relapsed/refractory multiple myeloma (RRMM) and advanced chronic kidney disease (CKD) are often excluded from clinical trials, leaving treatment gaps for these high-risk patients. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/novel-therapies-needed-for-older-patients-with-rrmm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/0636f60ec186da460f794acfef0878325c54f9ec-1200x738.jpg?fit=crop&auto=format" alt="MM blood test | Image Credit: luchschenF-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">August 6th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/novel-therapies-needed-for-older-patients-with-rrmm">Novel Therapies Needed for Older Patients With RRMM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/novel-therapies-needed-for-older-patients-with-rrmm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Relapsed/refractory multiple myeloma (RRMM) remains an incurable hematologic cancer, often resulting in patients treated with several classes of medications—particularly older patients.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/daratumumab-and-hyaluronidase-fihj-based-quadruplet-approved-in-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f2d1812ac576b862153d30d4fe7e135bec6ddffc-1200x738.jpg?fit=crop&auto=format" alt="FDA | Image Credit: ra2studio-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 31st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/daratumumab-and-hyaluronidase-fihj-based-quadruplet-approved-in-mm">Daratumumab and Hyaluronidase-fihj–Based Quadruplet Regimen Approved in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/daratumumab-and-hyaluronidase-fihj-based-quadruplet-approved-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Daratumumab/hyaluronidase-fihj plus bortezomib, lenalidomide, and dexamethasone is now approved by the FDA to treat newly diagnosed multiple myeloma (MM) in patients eligible for autologous stem cell transplant. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/beyond-eha-2024-promising-research-in-multiple-myeloma-to-watch"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f6b179d9974841eb0d393e097d87babad52e750c-1920x1080.png?fit=crop&auto=format" alt="Joseph Mikhael, MD, an expert on multiple myeloma" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/beyond-eha-2024-promising-research-in-multiple-myeloma-to-watch">Beyond EHA 2024: Promising Research in Multiple Myeloma to Watch</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/joseph-mikhael-md">Joseph Mikhael, MD</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/beyond-eha-2024-promising-research-in-multiple-myeloma-to-watch"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Dr. Mikhael discusses EHA 2024 data he found particularly noteworthy to share with colleagues. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/dual-target-car-t-cells-achieve-100-response-rate-in-mm"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a8ce964403b3f6531ee8a6c5d1ff46969a56666b-1200x728.jpg?fit=crop&auto=format" alt="CAR T in MM | Image Credit: LASZLO-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 w-full xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 font-bold article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">July 25th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/dual-target-car-t-cells-achieve-100-response-rate-in-mm">Dual-Target CAR T Cells Achieve 100% Response Rate in MM</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#000] text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/dual-target-car-t-cells-achieve-100-response-rate-in-mm"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">This new analysis examined the investigational chimeric antigen receptor (CAR) T-cell therapy GC012F among patients with newly diagnosed and high-risk multiple myeloma (MM).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div><div class="w-full text-center flex justify-center pb-24"><a class="px-4 py-2 border-y border-r bg-primary text-white" href="/compendium/multiple-myeloma?page=1">1</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=2">2</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=3">3</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=4">4</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=5">5</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=6">6</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=7">7</a><a class="px-4 py-2 border-y border-r " href="/compendium/multiple-myeloma?page=8">8</a><div class="px-4 py-2 border-y border-r">...</div><a class="px-4 py-2 border-y border-r" href="/compendium/multiple-myeloma?page=10">10</a><a class="px-4 py-2 border-y border-r" href="/compendium/multiple-myeloma?page=2">></a></div></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" 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It's striking, because at diagnosis, their number 1 goal—in this paper anyway—was overall survival. Nothing else mattered. And in the relapse/refractory setting, the number 1 goal, by far and away, was survival. The reason it's such an interesting paper is that that middle, that in-between, when the disease is in remission, it's all about quality of life. It's energy, fatigue, pain, cognitive function, independence, freedom. Those metrics take on substantially more meaning and importance for patients overall and beyond survival.","_key":"01fa067ca3940","_type":"span"}],"_type":"block","style":"normal"},{"_key":"b3547bc19325","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2c11316f10510"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Myeloma is not a sprint, it's a marathon. And I think as physicians, as specialists, we need to be sensitive to where patients are in the journey. When somebody is newly diagnosed, their risk tolerance is very different than when their disease is in remission and you're trying to cajole them into taking a maintenance pill that might cause diarrhea or it might cause a rash. This is what I mean by taking into account patients' desires and goals.","_key":"9c2dc2e2f59f0"}],"_type":"block","style":"normal","_key":"2c54f82fe451"},{"_key":"0519421b2b46","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"9c6eae269a0d0"}],"_type":"block","style":"normal"},{"style":"normal","_key":"4cab7ee5b2bf","markDefs":[],"children":[{"_key":"ba83c7a6b4cb0","_type":"span","marks":[],"text":"I'll give you another example. We had a patient last year who was diagnosed in the early part of the year, got induction treatment, got into remission, we collected his stem cells, and then his daughter got engaged. And she wanted to get married while dad was well. 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For newly diagnosed patients, I may use MRD testing to decide whether or not to pursue upfront transplant or a delayed transplant approach in standard-risk multiple myeloma patients. So, if a patient has standard risk multiple myeloma [and] has attained MRD negativity to frontline induction therapy, I may consider deferring transplant after a conversation about the risks and benefits with the patient."}],"_type":"block","style":"normal","_key":"0032007dc552"},{"children":[{"_type":"span","marks":[],"text":"","_key":"54e82bb05eda0"}],"_type":"block","style":"normal","_key":"d1b6f79c406d","markDefs":[]},{"_key":"98ed3d66e8a9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think on the back end, where MRD can also be very helpful is knowing when to deintensify therapy. I think we're getting more and more data about perhaps there are some patients who have been on long-term lenalidomide maintenance therapy after transplant who have sustained MRD negativity where we could potentially stop therapy. And there's now data coming out of a couple of groups, such as the University of Chicago and Memorial Sloan Kettering, that have shown that this approach is feasible, even after stopping lenalidomide maintenance in patients with sustained embryonic negativity, that these patients can remain in remission for a very long time. So, that's something else that I've also started to incorporate in my practice as well. And there are more and more prospective studies that are looking at this sort of deintensification of maintenance therapy based on MRD testing that will be reported in the future.","_key":"3fd1096fd92d0"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"06a001f80440","markDefs":[],"children":[{"marks":[],"text":"","_key":"8270d04002160","_type":"span"}]},{"_type":"block","style":"normal","_key":"c6b3def6ae8a","markDefs":[],"children":[{"_key":"cc116d7556740","_type":"span","marks":["strong"],"text":"How do you balance patient treatment selection with the need to optimize long-term outcomes and cost-effectiveness?"}]},{"_type":"block","style":"normal","_key":"f24eb04bce5a","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"261db23806ad0"}]},{"_type":"block","style":"normal","_key":"b85680e41780","markDefs":[],"children":[{"_type":"span","marks":[],"text":"It's really great that we have both options, CAR T therapies and bispecific antibodies, available for our patients in 2024. 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He also addresses the role of the immune system in this hematologic disease, the potential of curative therapies, and long-term survivors.","_key":"453d8b1aaaab"}],"_type":"block","style":"normal","_key":"30e462e8b6c4"},{"_key":"7ff6bf525271","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"99fcaa0793a30"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"“I think about it like a regression model,” Benson says. “There's multiple variables that go into determining this outcome. 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I think that it's a multifactorial outcome. So I think sometimes we, as physicians, feel like we have control of things because we have so many good treatments, we have combinations of treatments, we have radiation, we have all kinds of things at our disposal and things should work the way we want them to. And sometimes they don't. I've had patients with high-risk cytogenetics who, if they read the book, would have lived 2 years and are still alive 10 years later. And I've seen young patients with “standard risk” cytogenetics who die 3 or 4 years into their disease."}],"_type":"block"},{"style":"normal","_key":"9834839c2b79","markDefs":[],"children":[{"text":"So I think about it like a regression model. There's multiple variables that go into determining this outcome. It might be patient age, it might be their fitness, it might be the cytogenetics, the kind of myeloma they have. I had several patients who died of COVID-19 in the pandemic—in complete remission, and out of the blue, this global pandemic comes.","_key":"f14ca3a6a3200","_type":"span","marks":[]}],"_type":"block"},{"style":"normal","_key":"a1e49745593a","markDefs":[],"children":[{"_key":"9ed9dabe3bca0","_type":"span","marks":[],"text":"I think colloquially we call that variable "},{"_type":"span","marks":["em"],"text":"luck","_key":"9ed9dabe3bca1"},{"_type":"span","marks":[],"text":", but a lot of the research we do in our laboratory is looking at how the immune system interacts with the tumor. It’s not the molecular subtype of the myeloma that's driving outcome; it's the way the patient's immune system is trying to recognize and respond to the disease that's driving outcome. It's very clear in a basic science laboratory, but how do we make that actionable? 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Here, he highlights the transformative impact of bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapies on relapsed/refractory (R/R) ","_key":"7c6fbead35852","_type":"span","marks":[]},{"text":"multiple myeloma","_key":"7c6fbead35853","_type":"span","marks":["44cca15ea464"]},{"_type":"span","marks":[],"text":" and discusses the incorporation of anti–CD-38 monoclonal antibodies into frontline therapy.","_key":"7c6fbead35854"}],"_type":"block","style":"normal"},{"_key":"fac09999331e","markDefs":[],"children":[{"marks":[],"text":"","_key":"22d42371530b0","_type":"span"}],"_type":"block","style":"normal"},{"style":"normal","_key":"45069e05dc90","markDefs":[],"children":[{"marks":["em"],"text":"This transcript has been lightly edited for clarity.","_key":"f66f90853b1d0","_type":"span"}],"_type":"block"},{"_key":"3ae850d64365","markDefs":[],"children":[{"text":"","_key":"76918c44cf920","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"0ff2bc8ee9b90"}],"_type":"block","style":"normal","_key":"d599dbc20e1f"},{"children":[{"_type":"span","marks":[],"text":"","_key":"2e027d9499ec0"}],"_type":"block","style":"normal","_key":"fc5d45dda00a","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"How has integrating bispecific antibodies and CAR T-cell therapies altered treatment sequencing for R/R multiple myeloma?","_key":"105ea2b9526d0"}],"_type":"block","style":"normal","_key":"053de7b5df1c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3f85535a5d390"}],"_type":"block","style":"normal","_key":"35b1d09f25b6"},{"style":"normal","_key":"62f2c6107b36","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Bispecific T-cell antibodies and CAR T therapies have really transformed the treatment landscape for relapsed/refractory multiple myeloma over the last 2 to 3 years or so. Before their regulatory pools, we had very limited options for treatment of what we call triple class refractory multiple myeloma—these are patients who are refractory to IMiDs [immunomodulatory drugs], proteasome inhibitors, anti–CD-38 monoclonal antibodies. And the advent of bispecific antibodies and CAR T therapies have really provided a very efficacious therapy with not only high overall response rates, but durable responses for this challenging patient population to treat.","_key":"35259bc671090"}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"e8f5b16920380","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f3a737c48663"},{"children":[{"_type":"span","marks":["strong"],"text":"How do you see anti–CD-38 monoclonal antibodies changing the standard of care in multiple myeloma?","_key":"eaa6a68663540"}],"_type":"block","style":"normal","_key":"1414ad39d343","markDefs":[]},{"style":"normal","_key":"1512c5089a63","markDefs":[],"children":[{"marks":[],"text":"","_key":"39c1e7980b390","_type":"span"}],"_type":"block"},{"_key":"50a86098159b","markDefs":[],"children":[{"_key":"8e35b01d26a80","_type":"span","marks":[],"text":"Anti–CD-38 monoclonal antibodies like daratumumab and isatuximab have really transformed the landscape for the treatment of multiple myeloma, both in the relapsed setting [and] the newly diagnosed setting. And I think one of the most exciting things recently in the last couple years has been the incorporation of anti–CD-38 monoclonal antibodies in frontline therapy. Now, we have multiple studies showing the addition of anti–CD-38 monoclonal antibodies with the backbone of bortezomib/lenalidomide/dexamethasone, or even carfilzomib/dexamethasone really adds benefit in terms of not only MRD-negative rates, but also in some studies, progression-free survival as well."}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"8868838ac6600"}],"_type":"block","style":"normal","_key":"fcd75efd10e5","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"I think most of us would consider that the standard of care for newly diagnosed multiple myeloma should incorporate an anti–CD-38 monoclonal antibody plus a protease inhibitor [and] IMiD backbone as standard of care for both transplant-eligible and even transplant-ineligible patients who are fit to receive a quadruple-based therapy.","_key":"c0e4a800675e0"}],"_type":"block","style":"normal","_key":"ca52ad217044"}],"published":"2024-12-10T19:17:00.000Z","_createdAt":"2024-12-09T19:17:45Z","summary":"Hans Lee, MD, MD Anderson Cancer Center, talks about recent advancements in multiple myeloma treatment pathways. 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Systems need to balance the cost-effectiveness with the clinical effectiveness of newer treatments like chimeric antigen receptor T-cell therapies (CAR T) and bispecific monoclonal antibodies, he explained.","_key":"e3830b99cffb"}],"_type":"block"},{"_key":"aeb764836d2c","markDefs":[],"children":[{"_key":"9029875d9f34","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"dc380efa847e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Sanchez participated in a panel discussion on best practices in multiple myeloma care at a recent Institute for Value-Based Medicine","_key":"6df76e649f4f"},{"text":"®","_key":"18f9f111d84a","_type":"span","marks":["superscript"]},{"marks":[],"text":" event in Chicago.","_key":"28270978d2ac","_type":"span"}]},{"children":[{"_type":"span","marks":["em"],"text":"","_key":"f78659e583b3"}],"_type":"block","style":"normal","_key":"398fd8110714","markDefs":[]},{"children":[{"_type":"span","marks":["em"],"text":"This transcript has been lightly edited for clarity.","_key":"dd34b87b605e"}],"_type":"block","style":"normal","_key":"7915019e56e0","markDefs":[]},{"_type":"block","style":"normal","_key":"1f8c276e87c4","markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"","_key":"cdb81f287a21"}]},{"_type":"block","style":"normal","_key":"d9bed6a84632","markDefs":[],"children":[{"_key":"7389bc8ad90b","_type":"span","marks":["strong","underline"],"text":"Transcript"}]},{"_key":"58144b501006","markDefs":[],"children":[{"_key":"c7f6c0a660e3","_type":"span","marks":["strong"],"text":""}],"_type":"block","style":"normal"},{"_key":"e021c39f3590","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What are some of the most notable advancements you’ve seen in the treatment of multiple myeloma in recent years, and how have they impacted patient outcomes?","_key":"feb1221a7d480"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"089e81a84ce2"}],"_type":"block","style":"normal","_key":"1b81852ae5ad"},{"style":"normal","_key":"0c4723cc0a2c","markDefs":[],"children":[{"marks":[],"text":"We've seen great achievements. I think one of the most important ones has been the addition of the anti–CD-38 monoclonal antibodies, and adding them to the backbone of RBD [lenalidomide (Revlimid), bortezomib, and dexamethasone] or KRD [carfilzomib (Kyprolis), lenalidomide, and dexamethason] previous treatments. With those [as] induction chemotherapy, we've had the greatest responses that we've ever seen in multiple myeloma. So I think that has certainly affected the outcome in terms of response rates, progression-free survival, and hopefully overall survival in the future. We're excited to see that. Additionally, cell therapies and bispecifics are very interesting therapies. So we're excited to see myeloma [treatments] moving there as well.","_key":"280466ff607e0","_type":"span"}],"_type":"block"},{"style":"normal","_key":"a1eaeb9b1b92","markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"","_key":"34db0c36d057"}],"_type":"block"},{"style":"normal","_key":"61201454f0bf","markDefs":[],"children":[{"text":"How do you approach the challenge of balancing cost-effectiveness with clinical effectiveness when incorporating novel therapies like CAR T and bispecific antibodies into multiple myeloma care?","_key":"e145ab661d3b0","_type":"span","marks":["strong"]}],"_type":"block"},{"_type":"block","style":"normal","_key":"e941fa925dcf","markDefs":[],"children":[{"text":"","_key":"fa6d961b679e","_type":"span","marks":[]}]},{"_key":"42f8940512f7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"That's a great question. [With] all of our therapies, the better they get, the more expensive they get. So that's a challenge, and it's a challenge for our system. For the most part, so far, I think we always put efficacy first. In that way, I think using CAR Ts are the most efficacious treatments, and then bipecifics. But again, I think that's the challenge we all have. I work where we see a patient population who is insured by Medicare or Medicaid, so we are more limited than other institutions in the state, so we have to be cognizant of that or of what treatments we're going to give. 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I'm from the transplant world, so that's where we really need to make sure the patient has a caregiver or has someone who can help them navigate the system and help them with the chores. Usually with our patient population that we take care at UIC, we try to always make sure the patient has someone who can help navigate everything, the whole transplant or chemotherapy process, everything. I think it's the most important thing. And it's a team, so our nurses do a great job there, too.","_key":"5ae18d7fd6f60"}],"_type":"block","style":"normal","_key":"bb5cef088d35"},{"children":[{"_key":"aae1b40ec78e","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"40cfee73e7c7","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"What advice would you give to other oncologists who are looking to adopt more value-based approaches to managing multiple myeloma?","_key":"2ad7234542580"}],"_type":"block","style":"normal","_key":"fe3ab3738fcd"},{"markDefs":[],"children":[{"text":"","_key":"5d2c058d87ea","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"2268d18ece05"},{"children":[{"text":"My advice would be to, first, use the most effective therapies for myeloma that you have up front, and don't be afraid to use the new therapies that are available, especially the bispecifics and CAR T. We can select the patients who are the best patients to whom we can give those treatments. Make sure patients are not very frail or ultra frail; we can adapt those treatments according to their frailty status. But don't be afraid either to use them. Because these are all new treatments that make us anxious and make us go, \"What are we going to do if the patient gets a fever?\"—all those things, yeah— but don't be afraid to try to use targeted therapies in the right patient.","_key":"f29cd95236790","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"5c501a207014","markDefs":[]}],"is_visible":true,"source":null},{"_rev":"Nphhc06GU7PslEeOdbRtob","_type":"article","url":{"current":"mrd-a-game-changer-in-multiple-myeloma","_type":"slug"},"contentCategory":{"_id":"ee14ccb3-3542-4414-9046-927be1198c76","_updatedAt":"2020-04-03T20:03:44Z","_createdAt":"2020-04-03T20:03:44Z","_rev":"Yw6MEKZDMdk6hC2JCPjfiB","_type":"contentCategory","name":"Videos"},"body":[{"_key":"f4b14cd49936","videoObject":{"videoDuration":"PT2M17S","videoDescription":"Interview with Surbhi Sidana, MD, MBBS","_type":"videoDetails","videoTitle":"MRD: A Game Changer in multiple myeloma","thumbnail":{"_type":"image","asset":{"_type":"reference","_ref":"image-d2d71ee7e41fc353ec8dc2a9dfdc27cc40cb40ac-1200x675-jpg"}}},"_type":"video","caption":"Surbhi Sidana, MD, MBBS","videoID":"6363688938112","disableAutoPlayVideo":false,"source":"brightcove"},{"_key":"001a5aba3648","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bd8a0bbc0d55"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"In part 2 of our interview with Surbhi Sidana, MD, MBBS, vice chair of the American Society of Hematology’s Committee on Communications and associate professor of medicine and director of the Myeloma Disease Focused Group at Stanford University, she delves into one of the hottest topics in the hematologic malignancy space today: minimal residual disease status.","_key":"2999cc26c4f60"}],"_type":"block","style":"normal","_key":"27b9cd91ebb2"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"57a82be0d7bd0","_type":"span"}],"_type":"block","style":"normal","_key":"d5dfea1bc93f"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Here she explains just what are these remnants of cancer that remain after completion of treatment and their significance to future treatment decisions and outcomes.","_key":"065a56b787ac0"}],"_type":"block","style":"normal","_key":"bc4a0fe69eed"},{"style":"normal","_key":"53e48d35b7f6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d6240b2a7d170"}],"_type":"block"},{"_type":"block","style":"normal","_key":"42505e0bddbf","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/view/isatuximab-approval-highlights-role-of-anti-cd38-antibody-in-myeloma-care","_key":"33ff064e5a57"},{"blank":true,"_type":"link","href":"https://www.ajmc.com/view/fda-approves-isatuximab-with-vrd-as-first-line-option-for-transplant-ineligible-multiple-myeloma","_key":"45288976db66"},{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/multiple-myeloma","_key":"b8fbc6cb991c"}],"children":[{"text":"Also make sure to check our ","_key":"233a7b9cfdfd0","_type":"span","marks":[]},{"marks":["33ff064e5a57"],"text":"part 1","_key":"233a7b9cfdfd1","_type":"span"},{"_type":"span","marks":[],"text":" of our exclusive interview with her regarding the recent ","_key":"233a7b9cfdfd2"},{"text":"FDA approval of isatuximab","_key":"233a7b9cfdfd3","_type":"span","marks":["45288976db66"]},{"_type":"span","marks":[],"text":" (Sarclisa; 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But this is like the iceberg: you can detect something on the surface, then you do a bone marrow [test and] you can detect something under the surface. But we know that even with those techniques, a lot of disease was left behind that they were just not sensitive enough to detect. So, MRD, or minimal residual disease, testing is just a more sensitive technique to detect disease that cannot be detected by conventional technologies."}],"_type":"block","style":"normal","_key":"42663d1d89af","markDefs":[]},{"style":"normal","_key":"d5c4a53f535f","markDefs":[],"children":[{"marks":[],"text":"","_key":"963bac9bb6f30","_type":"span"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"There's a couple of ways to do it by our current methodologies. Both of them right now rely on bone marrow testing: next-generation flow cytometry, which is an advanced flow cytometry to [provide a] more sensitive way of detection, or next-generation sequencing that detects the clone in myeloma at the time of diagnosis or relapse and tracks that clone through sequencing of the VDJ region in the plasma cell and just tracks that one clone to detect it at a very low level.","_key":"8f9de165a7cc0"}],"_type":"block","style":"normal","_key":"9cd8bd26c74c"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bcb4ac9e5d860"}],"_type":"block","style":"normal","_key":"10f739c2a94b"},{"_type":"block","style":"normal","_key":"005a8ef2b630","markDefs":[],"children":[{"marks":[],"text":"It's just a sensitive way to detect disease that we couldn't previously detect. And what this tells us is that if you have low-level disease that we cannot detect by MRD—it doesn't mean there's no disease, just that these techniques cannot detect—those patients do better. We've seen that historically.","_key":"38d06ac96fe20","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e40841cfd7a60"}],"_type":"block","style":"normal","_key":"cf90ac37678c"},{"children":[{"_type":"span","marks":[],"text":"Now, the FDA ODAC [Oncologic Drugs Advisory Committee] came out ","_key":"54b2dae43cf80"},{"marks":["17839c83ace1"],"text":"with a decision","_key":"54b2dae43cf81","_type":"span"},{"_type":"span","marks":[],"text":" that MRD will be used as a surrogate end point. They're open to that as a surrogate end point for drug approval. So, I think the field is moving in that direction. So, yes, MRD negativity rates were actually higher in this clinical trial [IMROZ, NCT03319667] with a quadruplet induction.","_key":"54b2dae43cf82"}],"_type":"block","style":"normal","_key":"1759ec02d35c","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/view/after-odac-what-s-next-for-mrd-testing-in-multiple-myeloma-","_key":"17839c83ace1"}]},{"_key":"042a745eb7bc","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d5e4a676c1f00"}],"_type":"block","style":"normal"},{"style":"normal","_key":"d888804a3c5d","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/view/cepheus-sub-q-daratumumab-with-vrd-improves-mrd-negativity-pfs-in-myeloma-if-transplant-deferred","_key":"379fada9485e"}],"children":[{"_type":"span","marks":[],"text":"We just had the IMS 2024 meeting in Brazil, and there they presented another clinical trial, which was very similar, just used a different anti-CD38, ","_key":"b4c7a478db150"},{"_type":"span","marks":["379fada9485e"],"text":"the CEPHEUS trial","_key":"b4c7a478db151"},{"marks":[],"text":", where the primary end point was actually MRD negativity. 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This results in a great effect in the frontline setting of treatment for multiple myeloma.","_key":"702b7894016e","_type":"span"}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"45e024e269ba0"}],"_type":"block","style":"normal","_key":"00472c80195a"},{"style":"normal","_key":"4f659b993f62","markDefs":[],"children":[{"marks":[],"text":"At the same time, we are also aware of new developments like CAR [chimeric antigen receptor] T-cell treatments and treatments with bispecific antibodies.","_key":"542a2e47377b0","_type":"span"}],"_type":"block"},{"style":"normal","_key":"6659f5c3e0a4","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f456171e3d8c0"}],"_type":"block"},{"_key":"b53aaf0fb805","markDefs":[],"children":[{"text":"The organization for which I'm working, The European Myeloma Network [EMN], also coordinates 2 important trials in the frontline setting. One trial is comparing CAR T-cell treatment with standard autologous stem cell transplantation. This trial is ongoing in many countries around the world, coordinated by EMN.","_key":"6c8862d0afd30","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"ce37f7ff812d0"}],"_type":"block","style":"normal","_key":"306dac0fb23e","markDefs":[]},{"style":"normal","_key":"25f3bbc12420","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The other trial is about the use of bispecifics in the maintenance setting—in this case, teclistamab, also for a frontline treatment for patients with multiple myeloma. Trials have been done in the relapse setting and we know they are very effective, have very high response rates, and lasting responses of good quality.","_key":"4703da37a2820"}],"_type":"block"},{"style":"normal","_key":"d58d43cba6ea","markDefs":[],"children":[{"_key":"3da478fac5c10","_type":"span","marks":[],"text":""}],"_type":"block"},{"_key":"48e5ff43a8c4","markDefs":[],"children":[{"_key":"feccf4e2f14d0","_type":"span","marks":[],"text":"We expect that when moving these novel agents from the relapse setting to the frontline setting, the impact on the treatment in terms of response rate, but especially duration of response, will be huge."}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"5ac4d28ffae00"}],"_type":"block","style":"normal","_key":"6ba987eb24c5"},{"markDefs":[],"children":[{"_key":"2fb0ffc23d630","_type":"span","marks":[],"text":"We expect that this will be the next step in myeloma treatment that will set the new standard of care and we expect a lot from that. 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This gathering will bring together leading experts in the field to discuss the latest advancements in myeloma research, covering fundamental, preclinical, and clinical aspects of the disease.\n","_key":"a98f93c5e1a42","_type":"span"}],"_type":"block","style":"normal"},{"markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/multiple-myeloma","_key":"15fb77974f47","nofollow":false}],"children":[{"_key":"1108eff9e41c0","_type":"span","marks":[],"text":"Anant Madabhushi, PhD, executive director for the Emory Empathetic AI for Health Institute, proposes using AI to address disparities in "},{"marks":["15fb77974f47"],"text":"multiple myeloma","_key":"f088e1ce541c","_type":"span"},{"_type":"span","marks":[],"text":" care. He argues that systemic racism contributes significantly to these disparities, but there may also be subtle phenotypic differences between populations that can be identified to develop more tailored treatment approaches.","_key":"864dbe5dac2c"}],"_type":"block","style":"normal","_key":"53c17d5757f7"},{"_type":"block","style":"normal","_key":"b1a9ae95941e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ce9cc94aed4b"}]},{"markDefs":[],"children":[{"_key":"769a338eb5770","_type":"span","marks":["em"],"text":"This transcript has been lightly edited for clarity."}],"_type":"block","style":"normal","_key":"2335b8176cbd"},{"_key":"3f173340cb04","markDefs":[],"children":[{"_key":"d0e7e9787911","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_type":"span","marks":["strong","underline"],"text":"Transcript","_key":"54bbe7c7b5ac0"}],"_type":"block","style":"normal","_key":"6b46ee6339b3"},{"_type":"block","style":"normal","_key":"27e27c896cae","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c6e67eaa3420"}]},{"markDefs":[],"children":[{"marks":["strong"],"text":"How can AI help address disparities in multiple myeloma care and outcomes?","_key":"85210111e6fa0","_type":"span"}],"_type":"block","style":"normal","_key":"2f92b3120dc4"},{"_key":"04f32e0dfea7","markDefs":[],"children":[{"text":"","_key":"548faa8a9993","_type":"span","marks":[]}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"_key":"70260210740c0","_type":"span","marks":[],"text":"I will react by saying that the issue of disparities in cancer care is well established. We know that there are several different reasons for the disparities that we observe across different populations in the context of cancer care. Let's call out the 800-pound gorilla in the room. A lot of it has been the issue of systemic racism that has caused significant disparities in access and subsequently outcomes for different populations, particularly populations of color. As we look to better understand the disease, and we're seeing this in other cancers and other diseases, that beyond the social determinants of health and beyond the socioeconomic factors and access, we also are starting to acknowledge that there are subtle differences in the phenotype of the disease across different populations. And our work in prostate cancer and endometrial cancer has shown that using technologies like AI, we can start to tease out very subtle differences in the appearance of the disease across different populations. For instance, in prostate cancer and endometrial cancer, our work has revealed that there are cellular-level differences in the pathology images of, say, Black patients and White patients in the context of endometrial cancer and prostate cancer."}],"_type":"block","style":"normal","_key":"c28ee0147ae6"},{"_type":"block","style":"normal","_key":"0b4194fdb87c","markDefs":[],"children":[{"marks":[],"text":"","_key":"0a521e9fdba00","_type":"span"}]},{"children":[{"_key":"98c04f43b1950","_type":"span","marks":[],"text":"Again, I will repeat what I initially said. I know very little about multiple myeloma and I'm looking to learn at this particular meeting but I think that there's an opportunity to really use powerful technologies like AI to start to dive into understanding phenotypic differences between populations. I'm not suggesting that there are necessarily differences, but if there are differences, then we need to be cognizant of those differences and try to start accounting for that, potentially in starting to create more tailored AI models."}],"_type":"block","style":"normal","_key":"3bfeca32011f","markDefs":[]},{"_type":"block","style":"normal","_key":"04db5b94f6da","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"2bd9a88cbc0d0"}]},{"_key":"c5a25d8ecef2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"One of the things that AI has been accused of, quite rightly, is the fact that it is very prone to bias. It is very prone to exacerbating inequity and the only way to really address that is to be intentional about the way we develop the AI. To do that, we have to look at these approaches to try to understand, first and foremost, are there differences in the appearance of the disease across different populations? 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