Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.

<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes"> <title>Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.</title> <meta id="meta-title" property="citation_title" content="Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia."/> <meta id="og-title" property="og:title" content="Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia."/> <meta name="twitter:widgets:autoload" content="off"/> <meta name="twitter:dnt" content="on"/> <meta name="twitter:widgets:csp" content="on"/> <meta name="google-site-verification" content="lQbRRf0vgPqMbnbCsgELjAjIIyJjiIWo917M7hBshvI"/> <meta id="meta-abstract" name="citation_abstract" content="BackgroundOlfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.MethodsTo examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.ResultsOn the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.DiscussionOur data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed."/> <meta id="meta-description" name="description" content="Author(s): Woolley, JD; Lam, O; Chuang, B; Ford, JM; Mathalon, DH; Vinogradov, S | Abstract: BackgroundOlfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.MethodsTo examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.ResultsOn the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.DiscussionOur data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed."/> <meta id="og-description" name="og:description" content="Author(s): Woolley, JD; Lam, O; Chuang, B; Ford, JM; Mathalon, DH; Vinogradov, S | Abstract: BackgroundOlfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.MethodsTo examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.ResultsOn the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.DiscussionOur data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed."/> <meta id="og-image" property="og:image" content="https://escholarship.org/images/escholarship-facebook2.jpg"/> <meta id="og-image-width" property="og:image:width" content="1242"/> <meta id="og-image-height" property="og:image:height" content="1242"/> <meta id="meta-author0" name="citation_author" content="Woolley, JD"/> <meta id="meta-author1" name="citation_author" content="Lam, O"/> <meta id="meta-author2" name="citation_author" content="Chuang, B"/> <meta id="meta-author3" name="citation_author" content="Ford, JM"/> <meta id="meta-author4" name="citation_author" content="Mathalon, DH"/> <meta id="meta-author5" name="citation_author" content="Vinogradov, S"/> <meta id="meta-publication_date" name="citation_publication_date" content="2015-03-01"/> <meta id="meta-doi" name="citation_doi" content="10.1016/j.psyneuen.2014.12.018"/> <meta id="meta-online_date" name="citation_online_date" content="2015-04-01"/> <meta id="meta-pdf_url" name="citation_pdf_url" content="https://escholarship.org/content/qt33p084k7/qt33p084k7.pdf?t=nm4wn8"/> <link rel="canonical" href="https://escholarship.org/uc/item/33p084k7"/> <link rel="stylesheet" href="/css/main-fa87d2fbdbef47d2.css"> <link rel="resource" type="application/l10n" href="/node_modules/pdfjs-embed2/dist/locale/locale.properties"> <noscript><style> .jsonly { display: none } </style></noscript>   <script type="text/plain" data-type="application/javascript" data-name="matomo"> var _paq = window._paq = window._paq || []; 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</li><li><a href="/search/?q=author%3ALam%2C%20O">Lam, O</a>; </li><li><a href="/search/?q=author%3AChuang%2C%20B">Chuang, B</a>; </li><li><a href="/search/?q=author%3AFord%2C%20JM">Ford, JM</a>; </li><li><a href="/search/?q=author%3AMathalon%2C%20DH">Mathalon, DH</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AVinogradov%2C%20S">Vinogradov, S</a> </li></ul></div><div class="c-pubinfo"><h2 class="c-pubinfo__location-heading">Published Web Location</h2><a href="https://doi.org/10.1016/j.psyneuen.2014.12.018" class="c-pubinfo__link">https://doi.org/10.1016/j.psyneuen.2014.12.018</a><a href="https://creativecommons.org/licenses/by/4.0/" class="c-pubinfo__license"><img class="c-lazyimage" data-src="/images/cc-by-large.svg" alt="Creative Commons 'BY' version 4.0 license"/></a></div><div class="c-tabs"><div class="c-tabs__tabs"><button class="c-tabs__button-more" aria-label="Show all tabs">...</button><button class="c-tabs__button--active">Main Content</button><button class="c-tabs__button">Metrics</button><button class="c-tabs__button">Author & Article Info</button></div><div class="c-tabs__content"><div class="c-tabcontent"><a name="article_abstract"></a><details class="c-togglecontent" open=""><summary>Abstract</summary><div class="c-clientmarkup"><p><h3>Background</h3>Olfaction plays an important role in mammalian social behavior. Olfactory deficits are common in schizophrenia and correlate with negative symptoms and low social drive. Despite their prominence and possible clinical relevance, little is understood about the pathological mechanisms underlying olfactory deficits in schizophrenia and there are currently no effective treatments for these deficits. The prosocial neuropeptide oxytocin may affect the olfactory system when administered intranasally to humans and there is growing interest in its therapeutic potential in schizophrenia.<h3>Methods</h3>To examine this model, we administered 40IU of oxytocin and placebo intranasally to 31 patients with a schizophrenia spectrum illness and 34 age-matched healthy control participants in a randomized, double-blind, placebo-controlled, cross-over study. On each test day, participants completed an olfactory detection threshold test for two different odors: (1) lyral, a synthetic fragrance compound for which patients with schizophrenia have specific olfactory detection threshold deficits, possibly related to decreased cyclic adenosine 3',5'-monophosphate (cAMP) signaling; and (2) anise, a compound for which olfactory detection thresholds change with menstrual cycle phase in women.<h3>Results</h3>On the placebo test day, patients with schizophrenia did not significantly differ from healthy controls in detection of either odor. We found that oxytocin administration significantly and selectively improved olfactory detection thresholds for lyral but not for anise in patients with schizophrenia. In contrast, oxytocin had no effect on detection of either odor in healthy controls.<h3>Discussion</h3>Our data indicate that oxytocin administration may ameliorate olfactory deficits in schizophrenia and suggest the effects of intranasal oxytocin may extend to influencing the olfactory system. Given that oxytocin has been found to increase cAMP signaling in vitro a possible mechanism for these effects is discussed.</p></div><p class="o-well-colored">Many UC-authored scholarly publications are freely available on this site because of the UC's <a href="https://osc.universityofcalifornia.edu/open-access-at-uc/open-access-policy/">open access policies</a>. <a href="https://help.escholarship.org/support/tickets/new">Let us know how this access is important for you.</a></p></details><details class="c-togglecontent" open=""><a name="article_main"></a><summary>Main Content</summary><div class="c-pdfview"><button class="c-pdfview__button-download">Download PDF to View</button><button class="c-pdfview__button-view">View Larger</button></div><div class="c-pdfview__accessibility">For improved accessibility of PDF content, <a href="/content/qt33p084k7/qt33p084k7.pdf?t=nm4wn8">download the file</a> to your device.</div><div class="c-pdfview__viewer"><div id="pdfjs-cdl-wrapper"> <div 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<span data-l10n-id="print_progress_percent" data-l10n-args='{ "progress": 0 }' class="relative-progress">0%</span> </div> <div class="buttonRow"> <button id="printCancel" class="overlayButton"><span data-l10n-id="print_progress_close">Cancel</span></button> </div> </div> </div>     </div>  </div>  <div id="printContainer"></div> </div>  </div></div></details></div><p><br/></p></div></div></main><aside><section class="o-columnbox1"><header><h2>Jump To</h2></header><div class="c-jump"><a href="/uc/item/33p084k7">Article</a><ul class="c-jump__tree" aria-labelledby="c-jump__label"><li><a href="/uc/item/33p084k7">Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia</a></li><li><a href="/uc/item/33p084k7">1 Introduction</a></li><li><a href="/uc/item/33p084k7">2 Methods</a></li><li><a href="/uc/item/33p084k7">3 Results</a></li><li><a href="/uc/item/33p084k7">4 Discussion</a></li><li><a href="/uc/item/33p084k7">Contributors</a></li><li><a href="/uc/item/33p084k7">Role of the funding source</a></li><li><a href="/uc/item/33p084k7">Conflict of interest statement</a></li><li><a href="/uc/item/33p084k7">Acknowledgements</a></li><li><a href="/uc/item/33p084k7">Appendix A Supplementary data</a></li><li><a href="/uc/item/33p084k7">References</a></li></ul><ul class="c-jump__siblings"><li><a href="/uc/item/33p084k7">Metrics</a></li><li><a href="/uc/item/33p084k7">Author & Article Info</a></li></ul></div></section><div><section class="o-columnbox1"><header><h2>Related Items</h2></header><ul class="c-relateditems"><li><h3><a class="o-textlink__secondary" href="/uc/item/80n4s736"><div class="c-clientmarkup">Multiple forms of discrimination and obsessive-compulsive disorder: a prospective cohort study.</div></a></h3><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ANagata%2C%20Jason">Nagata, Jason</a>; </li><li><a 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Oxytocin administration selectively improves olfactory detection thresholds for lyral in patients with schizophrenia.