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It significantly reduced the b-hexosaminidase release from anti-DNP-IgE" /> <meta name="twitter:image" content="https://0.academia-photos.com/5178994/2280489/3327736/s200_sheikh.rayees.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/38426411/Ethanolic_Extract_of_Alternanthera_sessilis_AS_1_Inhibits_IgE_mediated_Allergic_Response_in_RBL_2H3_Cells" /> <meta property="og:title" content="Ethanolic Extract of Alternanthera sessilis (AS-1) Inhibits IgE-mediated Allergic Response in RBL-2H3 Cells" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The present study was designed to investigate the anti-allergic effects of ethanolic extract of Alternanthera sessilis (AS-1) in rat basophilic leukemia (RBL-2H3) cells. It significantly reduced the b-hexosaminidase release from anti-DNP-IgE" /> <meta property="article:author" content="https://iiim-in.academia.edu/SheikhRayees" /> <meta name="description" content="The present study was designed to investigate the anti-allergic effects of ethanolic extract of Alternanthera sessilis (AS-1) in rat basophilic leukemia (RBL-2H3) cells. 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window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":38426411,"created_at":"2019-02-23T13:32:29.698-08:00","from_world_paper_id":null,"updated_at":"2024-11-12T21:38:34.338-08:00","_data":{"grobid_abstract":"The present study was designed to investigate the anti-allergic effects of ethanolic extract of Alternanthera sessilis (AS-1) in rat basophilic leukemia (RBL-2H3) cells. It significantly reduced the b-hexosaminidase release from anti-DNP-IgE sensitized RBL-2H3 cells. AS-1also inhibited the IgE antibody-induced increase in Interleukin-6 (IL-6), TNF-a, IL-13 and IL-4 production in these cells. The inhibitory effect of AS-1 on these cytokine was found to be nuclear factor-KB (NF-kB) dependent, as it attenuated the degradation of IKBa and nuclear translocation of NFkB. In addition, AS-1 significantly attenuated the DNP HAS-induced intracellular Ca 2+ release from these cells, which makes us speculate strongly that the decreased intracellular Ca 2+ is involved in the inhibitory effect of AS-1 on b-hexoaminidase release. Taken together, anti-allergic effects of AS-1 suggest possible therapeutic application of this extract in allergic diseases.","grobid_abstract_attachment_id":"58485835"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Ethanolic Extract of Alternanthera sessilis (AS-1) Inhibits IgE-mediated Allergic Response in RBL-2H3 Cells","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [5178994]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":58485835,"attachmentType":"pdf"}"><img alt="First page of “Ethanolic Extract of Alternanthera sessilis (AS-1) Inhibits IgE-mediated Allergic Response in RBL-2H3 Cells”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/58485835/mini_magick20190223-29220-1f4pxzj.png?1550960901" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Ethanolic Extract of Alternanthera sessilis (AS-1) Inhibits IgE-mediated Allergic Response in RBL-2H3 Cells</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="5178994" href="https://iiim-in.academia.edu/SheikhRayees"><img alt="Profile image of Sheikh Rayees" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/5178994/2280489/3327736/s65_sheikh.rayees.jpg" />Sheikh Rayees</a></div><div class="ds-work-card--detail"><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">11 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 38426411; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The present study was designed to investigate the anti-allergic effects of ethanolic extract of Alternanthera sessilis (AS-1) in rat basophilic leukemia (RBL-2H3) cells. It significantly reduced the b-hexosaminidase release from anti-DNP-IgE sensitized RBL-2H3 cells. AS-1also inhibited the IgE antibody-induced increase in Interleukin-6 (IL-6), TNF-a, IL-13 and IL-4 production in these cells. The inhibitory effect of AS-1 on these cytokine was found to be nuclear factor-KB (NF-kB) dependent, as it attenuated the degradation of IKBa and nuclear translocation of NFkB. In addition, AS-1 significantly attenuated the DNP HAS-induced intracellular Ca 2+ release from these cells, which makes us speculate strongly that the decreased intracellular Ca 2+ is involved in the inhibitory effect of AS-1 on b-hexoaminidase release. Taken together, anti-allergic effects of AS-1 suggest possible therapeutic application of this extract in allergic diseases.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":58485835,"attachmentType":"pdf","workUrl":"https://www.academia.edu/38426411/Ethanolic_Extract_of_Alternanthera_sessilis_AS_1_Inhibits_IgE_mediated_Allergic_Response_in_RBL_2H3_Cells"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":58485835,"attachmentType":"pdf","workUrl":"https://www.academia.edu/38426411/Ethanolic_Extract_of_Alternanthera_sessilis_AS_1_Inhibits_IgE_mediated_Allergic_Response_in_RBL_2H3_Cells"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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In this study, we isolated the 9 kinds of SQTLs from Eupatorium chinense L. and examined the effects of these SQTLs on the degranulation in RBL-2H3 cells. The chemical structures of two novel compounds (SQTL-3 and 8) were determined. All the SQTLs suppressed the degranulation from Ag-stimulated RBL-2H3 cells. To disclose the inhibitory mechanism of degranulation by SQTLs, we examined the activation of intracellular signaling molecules such as Lyn, Syk, and PLCcs and intracellular free Ca 2+ concentration ([Ca 2+ ]i). None of these SQTLs showed the activation of Syk and PLCcs. The intracellular free Ca 2+ concentration ([Ca 2+ ]i) was elevated by FceRI activation, but SQTLs treatment reduced the elevation of [Ca 2+ ]i by suppressing Ca 2+ influx. Thus, it was suggested that the suppression of Ag-stimulated degranulation by these SQTLs is mainly due to the decreased Ca 2+ influx. Furthermore, in order to clarify the in vivo effect of SQTL-rich extract, we administered SQTL-rich extract to the type I allergic model mice and measured the passive cutaneous anaphylaxis (PCA) reaction induced by IgE-antigen complex. The SQTLs remarkably suppressed PCA reaction in a dose-dependent manner. Thus, it was suggested that SQTLs would be a candidate as an anti-allergic agent.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice","attachmentId":69664788,"attachmentType":"pdf","work_url":"https://www.academia.edu/52368028/Inhibitory_effects_of_sesquiterpene_lactones_isolated_from_Eupatorium_chinense_L_on_IgE_mediated_degranulation_in_rat_basophilic_leukemia_RBL_2H3_cells_and_passive_cutaneous_anaphylaxis_reaction_in_mice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52368028/Inhibitory_effects_of_sesquiterpene_lactones_isolated_from_Eupatorium_chinense_L_on_IgE_mediated_degranulation_in_rat_basophilic_leukemia_RBL_2H3_cells_and_passive_cutaneous_anaphylaxis_reaction_in_mice"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="30121358" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30121358/Suppressive_effects_of_Schizandra_chinensis_Baillon_water_extract_on_allergy_related_cytokine_generation_and_degranulation_in_IgE_antigen_complex_stimulated_RBL_2H3_cells">Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57146138" href="https://hanyang.academia.edu/DaejungKim">Daejung Kim</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nutrition Research and Practice, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited β-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-α) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells","attachmentId":50582179,"attachmentType":"pdf","work_url":"https://www.academia.edu/30121358/Suppressive_effects_of_Schizandra_chinensis_Baillon_water_extract_on_allergy_related_cytokine_generation_and_degranulation_in_IgE_antigen_complex_stimulated_RBL_2H3_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30121358/Suppressive_effects_of_Schizandra_chinensis_Baillon_water_extract_on_allergy_related_cytokine_generation_and_degranulation_in_IgE_antigen_complex_stimulated_RBL_2H3_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="31982881" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31982881/Central_stimulating_and_analgesic_activity_of_the_ethanolic_extract_of_Alternanthera_sessilis_in_mice">Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2293921" href="https://utu.academia.edu/SanjibSaha">Sanjib Saha</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="133695130" href="https://independent.academia.edu/AbdulwaliAblat">Abdulwali Ablat</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="11199880" href="https://foodsciencebangladeshcouncilscientificindustrialresearch.academia.edu/HemayetHossain">Hemayet Hossain</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Background Alternanthera sessilis is a popular vegetable and used in traditional medicinal practice of Bangladesh and other parts of Asia to relive tiredness, laziness, and sleeps as well as pain and inflammation. However, no report was found on the neuropharmacological and analgesic activity of this plant to-date. Present study was undertaken to evaluate the neuropharmacological and analgesic activity of the ethanol extract of A. sessilis whole plant (ETAS) in mice models. Methods Central stimulating activity was investigated by pentobarbitone induced sleeping time, open field, and hole cross tests. Analgesic activity was evaluated by acetic acid induced writhing and hot-plate methods. The tests were performed at 250 and 500 mg/kg body weight dose levels. Results In sleeping time test, ETAS significantly (p < 0.001) increased the onset of sleep, and decreased the duration of sleep. In open field and hole cross tests, ETAS significantly (p < 0.001) increased the movements of mice which persisted throughout the study period. In writhing test, ETAS showed, significant (p < 0.001) inhibition of writhing reflex. In hot plate test, ETAS significantly (p < 0.001) raised the pain threshold. In HPLC analysis for polyphenols, (+)-catechin, rutin, ellagic acid, and quercetin were detected in ETAS (117.72, 490.74, 3007.26, and 13.85 mg/100 g of dry extract, respectively). Conclusion Present study supported the traditional uses of A. sessilis and indicated that the plant can be a potential source of bioactive molecules.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice","attachmentId":52254622,"attachmentType":"pdf","work_url":"https://www.academia.edu/31982881/Central_stimulating_and_analgesic_activity_of_the_ethanolic_extract_of_Alternanthera_sessilis_in_mice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31982881/Central_stimulating_and_analgesic_activity_of_the_ethanolic_extract_of_Alternanthera_sessilis_in_mice"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="116971971" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116971971/In_vivo_antiasthmatic_studies_and_phytochemical_characterization_on_the_stem_extracts_of_Alternanthera_sessilis_L_using_Guinea_pigs_model">In vivo antiasthmatic studies & phytochemical characterization on the stem extracts of Alternanthera sessilis L. using Guinea pigs model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="300327637" href="https://independent.academia.edu/SkAbdulrahaman1">Sk Abdul rahaman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of entomology and zoology studies, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">The present investigation has been carried out to evaluate the antiasthmatic activity by in vitro and in vivo models in guinea pigs followed by phytochemical characterization using Gas chromatography Mass spectrum analysis of the hydroalcoholic and acetone extracts of the stem extracts of Alternanthera sessilis. In histamine and acetylcholine-induced bronchospasm studies acetone extracts of the plant have significantly increased PCT 10.52 and 11.36 by Tukey’s test (**p&lt;0.01), compared with control. Histamine and acetylcholine-induced ileum contraction studies also showed that the acetone extracts exhibited response was1.8 with 63.3% and 2.7 with 51% inhibition by Dunnett’s test (p&lt;*0.05). The results of GC-MS analysis depicted following phytoconstituents with major peak area namely 79.29% methoxy-bis (cyclopentadiene), 2.83% 5,10-dihexyl-5,10-dihydroindolo[3,2-b]indole-2,7-dicarbaldehyde and 1.84% 1,2-bis[3,4-dimethoxy benzyl]-1,2-bis (methoxymethyl) ethane respectively. The r...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In vivo antiasthmatic studies \u0026 phytochemical characterization on the stem extracts of Alternanthera sessilis L. using Guinea pigs model","attachmentId":112954148,"attachmentType":"pdf","work_url":"https://www.academia.edu/116971971/In_vivo_antiasthmatic_studies_and_phytochemical_characterization_on_the_stem_extracts_of_Alternanthera_sessilis_L_using_Guinea_pigs_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/116971971/In_vivo_antiasthmatic_studies_and_phytochemical_characterization_on_the_stem_extracts_of_Alternanthera_sessilis_L_using_Guinea_pigs_model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="74018952" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74018952/The_Extract_of_Kincung_Flower_Etlingera_elatior_Jack_R_M_Sm_Activity_to_Decrease_IL_4_and_IgE_Levels_in_Type_I_Hypersensitivity_White_Male_Mice">The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33465211" href="https://independent.academia.edu/YufriAldi">Yufri Aldi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pharmacognosy Journal</p><p class="ds-related-work--abstract ds2-5-body-sm">Recent research of kincung flower (Etlingera elatior (Jack) R.M.Sm.) showed it could be used as an alternative drug for anti-allergies because it had activity in inhibiting the active cutaneous anaphylactic reaction in mice. 11-13 It could inhibit degranulation of mice mast cells 12,13, which decreased basophils, eosinophils and lymphocytes. It increased neutrophils and the total number of leukocytes. 13 Kincung flower had properties as and anti-cancer and tumours. 13-17 It showed anti-cancer activity against cervical cancer cells and skin cancer. 13,16,17 Kincung flower also contained high antioxidants 13, ABSTRACT Introduction: Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) is a herbal plant which contains many secondary metabolites. It showed to suppress allergic reactions by inhibiting mast cell degranulation, active cutaneous anaphylaxis and decreasing the number of basophils and eosinophils. Aim: The study conducted to determine the decreased IL-4 and IgE level of type I hypersensitivity male white mice using kincung flowers extract. Material and Methods: The maceration method used to make ethanol extract of Kincung flower (Etlingera elatior (Jack) R.M.Sm.). The research used 25 allergic male white mice, which made by injected 20% albumen that given on the first day 0.2 mL/20 g intraperitoneally. On the seventh day are given albumen with the same dose subcutaneously. The characteristic of the allergic mice is the redness at the injection site. It divided into five groups: the negative control group, the positive control group and three dose groups (100; 300; and 1000 mg/kg). After mice given extract for seven days, then measured IgE and IL-4 levels in the serum of mice. Results: The results after three dose groups (100; 300; and 1000 mg/kg) given, the negative and positive control group showed sequentially the IL-4 level was: 33.024; 27.933; 25.192; 23.130 and 41.538 ng/ mL. And IgE level in serum was 0.944; 0.629; 0.210; and 1,597 µg/ mL. Conclusion: It concluded that kincung flowers decreased IL-4 and IgE level significantly (p<0.05). So it could use as an anti-allergic drug.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice","attachmentId":82323961,"attachmentType":"pdf","work_url":"https://www.academia.edu/74018952/The_Extract_of_Kincung_Flower_Etlingera_elatior_Jack_R_M_Sm_Activity_to_Decrease_IL_4_and_IgE_Levels_in_Type_I_Hypersensitivity_White_Male_Mice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/74018952/The_Extract_of_Kincung_Flower_Etlingera_elatior_Jack_R_M_Sm_Activity_to_Decrease_IL_4_and_IgE_Levels_in_Type_I_Hypersensitivity_White_Male_Mice"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="77921363" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/77921363/Anti_Inflammatory_Activity_Is_a_Possible_Mechanism_by_Which_the_Polyherbal_Formulation_Comprised_ofNigella_sativa_Seeds_Hemidesmus_indicus_Root_andSmilax_glabra_Rhizome_Mediates_Its_Antihepatocarcinogenic_Effects">Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised ofNigella sativa(Seeds),Hemidesmus indicus(Root), andSmilax glabra(Rhizome) Mediates Its Antihepatocarcinogenic Effects</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42905989" href="https://independent.academia.edu/IraThabrew">Ira Thabrew</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evidence-Based Complementary and Alternative Medicine, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">The present study investigated the anti-inflammatory effects of a polyherbal decoction comprised ofNigella sativa, Hemidesmus indicus, andSmilax glabrain order to justify its claimed antihepatocarcinogenic activity. Activation of hepatic nuclear factor-kappa B (NF-κB), IκB kinase (IKKα/β) proteins, and TNFαand IL-6 expression was investigated in diethylnitrosamine- (DEN-) induced C3H mice-bearing early hepatocarcinogenic changes. Acute phase inflammatory response was evaluated by carrageenan-induced rat paw edema formation. Anti-inflammatory mechanisms were also assessed by determining effect on (a) membrane stabilization, (b) nitric oxide (NO) inhibitory activity, and (c) inhibition of leukocyte migration. A significant inhibition of the paw edema formation was observed in healthy rats as well as in rats bearing early hepatocarcinogenic changes with oral administration of the decoction. As with the positive control, indomethacin (10 mg/kg b.w.) the inhibitory effect was pronounced ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised ofNigella sativa(Seeds),Hemidesmus indicus(Root), andSmilax glabra(Rhizome) Mediates Its Antihepatocarcinogenic Effects","attachmentId":85147689,"attachmentType":"pdf","work_url":"https://www.academia.edu/77921363/Anti_Inflammatory_Activity_Is_a_Possible_Mechanism_by_Which_the_Polyherbal_Formulation_Comprised_ofNigella_sativa_Seeds_Hemidesmus_indicus_Root_andSmilax_glabra_Rhizome_Mediates_Its_Antihepatocarcinogenic_Effects","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/77921363/Anti_Inflammatory_Activity_Is_a_Possible_Mechanism_by_Which_the_Polyherbal_Formulation_Comprised_ofNigella_sativa_Seeds_Hemidesmus_indicus_Root_andSmilax_glabra_Rhizome_Mediates_Its_Antihepatocarcinogenic_Effects"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="10309725" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/10309725/Pharmacological_study_of_anti_allergic_activity_of_Syzygium_cumini_L_Skeels">Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="25267467" href="https://independent.academia.edu/Andr%C3%A9Sampaio4">André Sampaio</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brazilian Journal of Medical and Biological Research, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Myrtaceae is a plant family widely used in folk medicine and Syzygium and Eugenia are among the most important genera. We investigated the anti-allergic properties of an aqueous leaf extract of Syzygium cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins and flavonoids are the major components of the extract. Oral administration of SC (25-100 mg/kg) in Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P ≤ 0.05) and, to a lesser extent, the allergic paw edema (23% inhibition, 100 mg/kg; P ≤ 0.05). SC treatment also inhibited the edema induced by histamine (58% inhibition; P ≤ 0.05) and 5-HT (52% inhibition; P ≤ 0.05) but had no effect on plateletaggregating factor-induced paw edema. SC prevented mast cell degranulation and the consequent histamine release in Wistar rat (180-200 g; N = 7/group) peritoneal mast cells (50% inhibition, 1 µg/mL; P ≤ 0.05) induced by compound 48/80. Pre-treatment of BALB/c mice (18-20 g; N = 7/group) with 100 mg/kg of the extract significantly inhibited eosinophil accumulation in allergic pleurisy (from 7.662 ± 1.524 to 1.89 ± 0.336 x 10 6 /cavity; P ≤ 0.001). This effect was related to the inhibition of IL-5 (from 70.9 ± 25.2 to 12.05 ± 7.165 pg/mL) and CCL11/eotaxin levels (from 60.4 ± 8.54 to 32.8 ± 8.4 ng/mL) in pleural lavage fluid, using ELISA. These findings demonstrate an anti-allergic effect of SC, and indicate that its anti-edematogenic effect is due to the inhibition of mast cell degranulation and of histamine and serotonin effects, whereas the inhibition of eosinophil accumulation in the allergic pleurisy model is probably due to an impairment of CCL11/eotaxin and IL-5 production.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels","attachmentId":47443671,"attachmentType":"pdf","work_url":"https://www.academia.edu/10309725/Pharmacological_study_of_anti_allergic_activity_of_Syzygium_cumini_L_Skeels","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/10309725/Pharmacological_study_of_anti_allergic_activity_of_Syzygium_cumini_L_Skeels"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="89691967" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/89691967/Monoterpenes_Isolated_fromMinthostachys_verticillata_Griseb_Epling_Essential_Oil_Modulates_Immediate_Type_Hypersensitivity_ResponsesIn_VitroandIn_Vivo">Monoterpenes Isolated fromMinthostachys verticillata(Griseb.) Epling Essential Oil Modulates Immediate-Type Hypersensitivity ResponsesIn VitroandIn Vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="191239359" href="https://independent.academia.edu/JZYGADLO">JULIO ZYGADLO</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Planta Medica, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">Minthostachys verticillata l " Lamiaceae l " essential oil l " monoterpenes l " immediate-type allergic reaction</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Monoterpenes Isolated fromMinthostachys verticillata(Griseb.) Epling Essential Oil Modulates Immediate-Type Hypersensitivity ResponsesIn VitroandIn Vivo","attachmentId":93443207,"attachmentType":"pdf","work_url":"https://www.academia.edu/89691967/Monoterpenes_Isolated_fromMinthostachys_verticillata_Griseb_Epling_Essential_Oil_Modulates_Immediate_Type_Hypersensitivity_ResponsesIn_VitroandIn_Vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/89691967/Monoterpenes_Isolated_fromMinthostachys_verticillata_Griseb_Epling_Essential_Oil_Modulates_Immediate_Type_Hypersensitivity_ResponsesIn_VitroandIn_Vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="17166814" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17166814/The_anti_allergic_activity_of_Cymbopogon_citratus_is_mediated_via_inhibition_of_nuclear_factor_kappa_B_Nf_%CE%9Ab_activation">The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36764723" href="https://independent.academia.edu/CostaRyan">Ryan Costa</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36871114" href="https://iaene.academia.edu/MartaMachado">Marta Machado</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36890418" href="https://independent.academia.edu/RaimonRios">Raimon Rios</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BMC Complementary and Alternative Medicine, 2015</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: The prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma. Methods: We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model. A/J mice were sensitized (100 μg/animal s.c.) and challenged (10 μg/ animal i.n.) with Bt mite extract and treated with 60, 120 or 180 mg/kg of Cy standardized hexane extract. The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; Th2 cytokine concentrations in BAL and expression of NF-κB. Results: Our results showed that oral administration of a Cy hexane extract (especially 180 mg/Kg) reduced the numbers of leukocytes/eosinophils in BAL; the eosinophil peroxidase activity in BAL; the infiltration of leukocytes in lung tissue; the production of mucus in the respiratory tract; the level of IL-4 in BAL and the nuclear expression of NF-κB.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation","attachmentId":42297326,"attachmentType":"pdf","work_url":"https://www.academia.edu/17166814/The_anti_allergic_activity_of_Cymbopogon_citratus_is_mediated_via_inhibition_of_nuclear_factor_kappa_B_Nf_%CE%9Ab_activation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17166814/The_anti_allergic_activity_of_Cymbopogon_citratus_is_mediated_via_inhibition_of_nuclear_factor_kappa_B_Nf_%CE%9Ab_activation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="7826244" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7826244/Immunomodulatory_activity_of_Semecarpus_anacardium_extract_in_mononuclear_cells_of_normal_individuals_and_rheumatoid_arthritis_patients">Immunomodulatory activity of Semecarpus anacardium extract in mononuclear cells of normal individuals and rheumatoid arthritis patients</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="14530920" href="https://independent.academia.edu/divyasingh39">divya singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Ethnopharmacology, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Semecarpus anacardium (SA) Linn. (family Anacardiaceae), is a plant well-known for its medicinal value in Ayurveda. The nut extracts of this plant have been traditionally used as antihelminthic, anti-fungal, anti-carcinogenic and in the treatment of nervous debilities and arthritis. In this study we have evaluated crude ethanolic extract of SA nuts for its anti-inflammatory activities in vitro using peripheral blood and synovial fluid mononuclear cells of healthy individuals and rheumatoid arthritis (RA) patients. SA extract inhibited the spontaneous and LPS induced production of proinflammatory cytokines IL-1␤ and IL-12p40 but had no effect on TNF-␣ and IL-6 production, both at protein and mRNA level.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunomodulatory activity of Semecarpus anacardium extract in mononuclear cells of normal individuals and rheumatoid arthritis patients","attachmentId":48325488,"attachmentType":"pdf","work_url":"https://www.academia.edu/7826244/Immunomodulatory_activity_of_Semecarpus_anacardium_extract_in_mononuclear_cells_of_normal_individuals_and_rheumatoid_arthritis_patients","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/7826244/Immunomodulatory_activity_of_Semecarpus_anacardium_extract_in_mononuclear_cells_of_normal_individuals_and_rheumatoid_arthritis_patients"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":58485835,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":58485835,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_58485835" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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