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Treatment Center Directory | AMVUTTRA® (vutrisiran)

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<div class="node__content"> <div class="sections basic_page_with_sections__item"> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-11/5-2-hero-couple-silo-dt.png" width="532" height="511" alt="Spectator couple hero image" loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --image"> <div class="image-mobile1"> <div class="image-mobile1__item"> <div class="media media--image --view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-11/5-2-hero-mb.png" width="375" height="206" alt="Spectator couple hero image" loading="lazy" /> </div> </div> </div> </div> </div> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-11/5-2_hero_background-field-dt.png" width="1366" height="534" alt="Hero Treatment Center Directory" loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --large_text"> <h2>Treatment Center Directory</h2> <h3>Search the AMVUTTRA<sup>®</sup> Treatment Center Directory to locate the treatment center closest to your patient</h3> </div> <div class="blocks__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="form"> <div class="form__item"><span id="webform-submission-infusion-center-finder-block-content-28-form-ajax-content"></span><div id="webform-submission-infusion-center-finder-block-content-28-form-ajax" class="webform-ajax-form-wrapper" data-effect="none" data-progress-type="fullscreen"><form class="webform-submission-form webform-submission-add-form webform-submission-infusion-center-finder-form webform-submission-infusion-center-finder-add-form webform-submission-infusion-center-finder-block_content-28-form webform-submission-infusion-center-finder-block_content-28-add-form webform-submission-infusion-center-finder-block-content-28-add-form js-webform-details-toggle webform-details-toggle" data-drupal-selector="webform-submission-infusion-center-finder-block-content-28-add-form" action="/treatment-center-directory" method="post" id="webform-submission-infusion-center-finder-block-content-28-add-form" accept-charset="UTF-8"> <label data-drupal-selector="edit-city-state-or-zip-code" for="edit-city-state-or-zip-code">You must enter a <strong>city and state</strong>, or <strong>zip code</strong></label><div data-drupal-selector="edit-container" id="edit-container" class="js-form-wrapper form-wrapper"><div class="js-form-item form-item js-form-type-textfield form-item-location js-form-item-location form-no-label"> <label for="edit-location" class="visually-hidden js-form-required form-required">Location<span>*</span></label> <input data-drupal-selector="edit-location" type="text" id="edit-location" name="location" value="" size="60" maxlength="255" placeholder="Enter a location" class="form-text required" required="required" aria-required="true" /> </div> <div class="js-form-item form-item js-form-type-select form-item-distance js-form-item-distance form-no-label"> <label for="edit-distance" class="visually-hidden js-form-required form-required">Distance<span>*</span></label> <select class="js-webform-select2 webform-select2 form-select required" data-drupal-selector="edit-distance" id="edit-distance" name="distance" required="required" aria-required="true"><option value="10" selected="selected">within 10 miles</option><option value="15">within 15 miles</option><option value="25">within 25 miles</option><option value="50">within 50 miles</option><option value="100">within 100 miles</option></select> </div> <div data-drupal-selector="edit-actions" class="form-actions webform-actions js-form-wrapper form-wrapper" id="edit-actions"><input class="webform-button--submit button button--primary js-form-submit form-submit" data-drupal-selector="edit-actions-submit" data-disable-refocus="true" type="submit" id="edit-actions-submit" name="op" value="Find" /> </div> </div> <label class="no-results-message" data-drupal-selector="edit-no-results-message" for="edit-no-results-message">No results. Try broadening your search mile radius.</label><label class="location-error-message" data-drupal-selector="edit-location-error-message" for="edit-location-error-message">Please enter city, state, or zip code.</label><input autocomplete="off" data-drupal-selector="form-un-vxmshelutfct-6hhuju8byb5yoaxn3xpha4-7ll4" type="hidden" name="form_build_id" value="form-Un_VxmSHeLUTFcT_6HHUJU8byB5yOaxn3xPha4_7lL4" /> <input data-drupal-selector="edit-webform-submission-infusion-center-finder-block-content-28-add-form" type="hidden" name="form_id" value="webform_submission_infusion_center_finder_block_content_28_add_form" /> </form> </div></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --large_text"> <h2>Treatment Center Directory</h2><h3>Search the AMVUTTRA<sup>®</sup> Treatment Center Directory to locate the treatment center closest to your patient</h3> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="form"> <div class="form__item"><span id="webform-submission-infusion-center-finder-block-content-28-form-ajax-content"></span><div id="webform-submission-infusion-center-finder-block-content-28-form-ajax" class="webform-ajax-form-wrapper" data-effect="none" data-progress-type="fullscreen"><form class="webform-submission-form webform-submission-add-form webform-submission-infusion-center-finder-form webform-submission-infusion-center-finder-add-form webform-submission-infusion-center-finder-block_content-28-form webform-submission-infusion-center-finder-block_content-28-add-form webform-submission-infusion-center-finder-block-content-28-add-form js-webform-details-toggle webform-details-toggle" data-drupal-selector="webform-submission-infusion-center-finder-block-content-28-add-form-2" action="/treatment-center-directory" method="post" id="webform-submission-infusion-center-finder-block-content-28-add-form--2" accept-charset="UTF-8"> <label data-drupal-selector="edit-city-state-or-zip-code" for="edit-city-state-or-zip-code--2">You must enter a <strong>city and state</strong>, or <strong>zip code</strong></label><div data-drupal-selector="edit-container" id="edit-container--2" class="js-form-wrapper form-wrapper"><div class="js-form-item form-item js-form-type-textfield form-item-location js-form-item-location form-no-label"> <label for="edit-location--2" class="visually-hidden js-form-required form-required">Location<span>*</span></label> <input data-drupal-selector="edit-location" type="text" id="edit-location--2" name="location" value="" size="60" maxlength="255" placeholder="Enter a location" class="form-text required" required="required" aria-required="true" /> </div> <div class="js-form-item form-item js-form-type-select form-item-distance js-form-item-distance form-no-label"> <label for="edit-distance--2" class="visually-hidden js-form-required form-required">Distance<span>*</span></label> <select class="js-webform-select2 webform-select2 form-select required" data-drupal-selector="edit-distance" id="edit-distance--2" name="distance" required="required" aria-required="true"><option value="10" selected="selected">within 10 miles</option><option value="15">within 15 miles</option><option value="25">within 25 miles</option><option value="50">within 50 miles</option><option value="100">within 100 miles</option></select> </div> <div data-drupal-selector="edit-actions" class="form-actions webform-actions js-form-wrapper form-wrapper" id="edit-actions--3"><input class="webform-button--submit button button--primary js-form-submit form-submit" data-drupal-selector="edit-actions-submit-2" data-disable-refocus="true" type="submit" id="edit-actions-submit--2" name="op" value="Find" /> </div> </div> <label class="no-results-message" data-drupal-selector="edit-no-results-message" for="edit-no-results-message--2">No results. Try broadening your search mile radius.</label><label class="location-error-message" data-drupal-selector="edit-location-error-message" for="edit-location-error-message--2">Please enter city, state, or zip code.</label><input autocomplete="off" data-drupal-selector="form-j-z8y6uvq1414qg55xlhrwoic-owmg2dxbh-7c7gik4" type="hidden" name="form_build_id" value="form-j-z8y6UvQ1414qG55XLhRwoiC_Owmg2dxbh_7C7Gik4" /> <input data-drupal-selector="edit-webform-submission-infusion-center-finder-block-content-28-add-form-2" type="hidden" name="form_id" value="webform_submission_infusion_center_finder_block_content_28_add_form" /> </form> </div></div> </div> </div> </div> </div> <div class="blocks__item --custom_html_code"> <div class="html-code"> <div class="html-code__item"><div class="infusion-center"><div class="content"><div class="map-container"><div class="search-map-result" id="map">&nbsp;</div></div><div class="results-container"><div class="search-results">&nbsp;</div><div class="email-results-container --modal_trigger"><a href="#send-results-form">Email a link to these results</a></div></div></div><div class="no-result hidden"><h4>No results? Try broadening your search</h4></div></div></div> </div> </div> </div> </div> </div> </div> <div class="sections__item --large_text"> <p>The AMVUTTRA Treatment Center Directory is for informational purposes only. No fees or other remuneration have been or will be exchanged for a treatment center’s inclusion in this database. Inclusion of centers in this database will be based on opt-in approval by authorized personnel for those sites listed. Inclusion in this database does not represent an endorsement of, recommendation for, or referral to the treatment centers listed in this database by Alnylam Pharmaceuticals. Likewise, participating treatment centers do not necessarily administer or endorse any Alnylam products.</p><p>To find other treatment centers near your patient, try using the <a href="https://locator.infusioncenter.org">National Infusion Center Association (NICA) Locator</a>.</p> </div> <div class="sections__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="paragraphs"> <div class="paragraphs__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --gray_block"> <div class="media"> <div class="media__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="130" height="109.08" viewBox="0 0 130 109.08"> <image id="treatmentCenter_4x" data-name="treatmentCenter@4x" width="130" height="109.08" 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</svg> </div> </div> </div> </div> </div> <div class="title"> <div class="title__item">Interested in being listed in the AMVUTTRA Online Treatment Center Directory?</div> </div> <div class="text"> <div class="text__item">&nbsp;</div> </div> <div class="link-icon"> <div class="link-icon__item --link_icon"><a class="link" href="/treatment-center-registration" title="Register now" muted="muted"> Register now <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" width="18.809" height="18.809" viewBox="0 0 18.809 18.809"> <g id="pin" transform="translate(0.87 -0.553)"> <path id="Path_32092" data-name="Path 32092" d="M0,0H18.809V18.809H0Z" transform="translate(-0.87 0.553)" fill="none"/> <g id="CTA_arrow" data-name="CTA arrow" transform="translate(6.13 3.552)"> <path id="Path" d="M0,0,5.334,6.141,0,12.282" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/> </g> </g> </svg> </div> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --large_text"> <p><a href="mailto:Treatment_Center_Directory@alnylam.com">Update or remove your contact information</a> from this directory.</p> </div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> </div> </div> </div> <div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> 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