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Reactions to this injection may happen during treatment with GIVLAARI.</p><p>Tell your doctor or nurse right away if you experience any of the following symptoms of an injection site reaction during treatment: redness, pain, itchiness, rash, discoloration, or swelling around the injection site.</p></li><li><p class="p-0 m-0"><strong>Increased blood homocysteine levels</strong></p><p>GIVLAARI may cause increased levels of homocysteine (a type of amino acid) in your blood. Your doctor will check your homocysteine levels before and during treatment by doing blood tests. If your levels are increased, your doctor may check your folate, vitamins B12 and B6, and tell you to take a vitamin B6 supplement.</p></li><li><p class="p-0 m-0"><strong>Inflammation of the pancreas (pancreatitis)</strong></p><p>Cases of acute pancreatitis including some that were severe, have been reported in patients receiving GIVLAARI. If you have a severe case of acute pancreatitis your doctor or nurse will decide whether to temporarily interrupt or stop treatment with GIVLAARI.</p></li></ul><p class="pb-0"><strong>What are the common side effects of GIVLAARI?</strong></p><p>The most common side effects of GIVLAARI are nausea and injection site reactions. These are not all the possible side effects of GIVLAARI. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</p><h3 class="isi-title white-space-nowrap">WHAT IS GIVLAARI<sup>®</sup> (givosiran)?</h3><p>GIVLAARI is a prescription medicine used to treat acute hepatic porphyria (AHP) in adults.</p><p><strong>For additional information about GIVLAARI, please see the full </strong><a href="https://www.alnylam.com/wp-content/uploads/pdfs/GIVLAARI-Prescribing-Information.pdf" target="_blank"><strong>Prescribing Information.</strong></a></p></div></section></section><div id="footer"><div class="footer_inner clearfix"><div class="footer_bottom_holder"><div class="up-footer"><img class="img-fluid" src="/themes/custom/effvision/images/dna-lines-footer.png" width="1175" height="16" loading="lazy"></div><div class="footer_bottom"><div class="textwidget"><div class="container"><div class="row"><div class="col-md-4"><div class="top_wrapper_links"><a href="https://www.alnylam.com/privacy-policy/">Privacy Policy</a> <a href="https://www.alnylam.com/legal-notice/">Legal Notice</a> <a href="https://alnylampolicies.com/contact#us/">Contact Us</a></div></div><div class="col-md-8"><div class="right-col-footer"><div class="left-footer-bottom" style="text-align:right;"><div class="copyright span">Copyright © 2024 Alnylam Pharmaceuticals, Inc. 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