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</nav> </div> <div class="flex items-center lg:hidden"> <a href="https://alnylamconnect.com/amvuttra" class="connect-with-educator-mobile ext-link-corporate"> <img class="red" src="/themes/amvuttra/assets/images/connect-icon.svg" alt="Connect with a rep icon"> <span>Connect</span> </a> <div class="toggle-menu flex justify-end ml-auto lg:hidden"> <img class="touch-none open show" src="/themes/amvuttra/assets/images/0.0-icn-hamburger.svg" width="30" height="23" alt="Open menu"> <img class="touch-none close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" width="30" height="30" alt="Close menu"> </div> </div> </div> </div> </header> <main class="main " role="main"> <a id="main-content" tabindex="-1"></a> <div class="main__content relative"> <div class="region region--content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-amvuttra-page-title" class="container page-title"> <h1><span>Efficacy</span> </h1> </div> <div id="block-amvuttra-content"> <article data-history-node-id="7" class="node node--basic-page-with-sections --view-mode--full"> <div class="node__content"> <div class="sections basic_page_with_sections__item"> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --large_text"> <h2>AMVUTTRA® significantly improved polyneuropathy<sup>1,2</sup></h2> <h3>Primary endpoint: change from baseline at 9 months in <span class="tool-tip tooltipstered" data-tooltip-content="#tooltip-mnis">mNIS+7</span><sup>1</sup></h3> <p id="primary" style="margin: 0px;height: 0px;"> </p> <ul> <li>mNIS+7 is a composite measure that assessed motor strength, reflexes, sensation, nerve conduction, and postural blood pressure (score range 0 to 304), with higher scores representing a greater severity of disease<sup>1</sup></li> </ul> <div class="tooltip-templates"> <div id="tooltip-mnis"><strong>mNIS+7</strong>=modified Neuropathy Impairment Score + 7.</div> </div> </div> <div class="blocks__item --tab_panel_2"><div class="tabs" data-active-tab="1"> <div class="tab-link active" data-target="1"> <span class="tab-label"> Change from baseline in mNIS+7<sup>1,2,a-c</sup> </span> </div> <div class="tab-link" data-target="2"> <span class="tab-label"> About mNIS+7 assessment<sup>1,3</sup> </span> </div> </div> <div class="panels"> <div class="panel active" data-panel="1"> <div class="inner-container"> <div class="--custom_html_code"> <div class="html-code"> <div class="html-code__item"><div class="--modal"><div class="title-toggler-container flex justify-between items-end lg:items-center mb-5"><div class="title"> </div><p><button class="toggle-modal open ml-auto"><img alt="Open modal" src="/themes/amvuttra/src/images/magnifying-glass-icon.svg"> <img alt="Open modal" src="/themes/amvuttra/src/images/magnify-hover.svg"></button></p></div><div class="image"><img src="/sites/default/files/2024-01/3.2-mnis_line_graph_18mo.svg" alt="Change in mNIS+7 from baseline at 18 months with AMVUTTRA® (vutrisiran) versus external placebo" width="775" height="375" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><sup>a</sup>Mean mNIS+7 at baseline was 60.6 with AMVUTTRA and 74.6 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -28.6 (95% CI: -34.0, -23.1).<sup>2</sup></p><p>CI=confidence interval; LS=least squares; SEM=standard error of the mean.</p></div><div class="modal"><div class="modal-overlay"> </div><div class="inner flex flex-col"><p><button class="toggle-modal close ml-auto"><img alt="Close modal" src="/themes/amvuttra/src/images/0.0-icn-x-lg.svg"></button></p><div class="title"><span>Change from baseline in mNIS+7<sup>1,2,a-c</sup></span></div><div class="image"><img src="/sites/default/files/2024-01/3.2-mnis_line_graph_18mo.svg" alt="Change in mNIS+7 from baseline at 18 months with AMVUTTRA® (vutrisiran) versus external placebo" width="775" height="375" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><sup>a</sup>Mean mNIS+7 at baseline was 60.6 with AMVUTTRA and 74.6 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -28.6 (95% CI: -34.0, -23.1).<sup>2</sup></p><p>CI=confidence interval; LS=least squares; SEM=standard error of the mean.</p></div></div></div></div></div> </div> </div> <div class="--large_text"> <div class="body footnotes"><p><sup>a</sup>Mean mNIS+7 at baseline was 60.6 with AMVUTTRA and 74.6 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -28.6 (95% CI: -34.0, -23.1).<sup>2</sup></p><p>CI=confidence interval; LS=least squares; SEM=standard error of the mean.</p></div> </div> </div> </div> <div class="panel " data-panel="2"> <div class="inner-container"> <div class="--custom_html_code"> <div class="html-code"> <div class="html-code__item"><div class="--modal"><div class="title-toggler-container flex justify-between items-end lg:items-center mb-5"><div class="title"> </div><p><button class="toggle-modal open ml-auto"><img alt="Open modal" src="/themes/amvuttra/src/images/magnifying-glass-icon.svg"> <img alt="Open modal" src="/themes/amvuttra/src/images/magnify-hover.svg"></button></p></div><div class="image"><img src="/sites/default/files/2022-09/3.2_modified_neuropathy_impairment_score%2B7.svg" alt="Modified Neuropathy Impairment Score + 7 (mNIS+7) components" width="489" height="482" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><strong>Modified Neuropathy Impairment Score + 7 (mNIS+7)<sup>1,3</sup></strong></p><ul><li>Validated composite measure of motor, sensory, and autonomic neuropathy, with a score ranging from 0 (no impairment) to 304 points, with higher scores representing a greater severity of disease</li></ul></div><div class="modal"><div class="modal-overlay"> </div><div class="inner flex flex-col"><p><button class="toggle-modal close ml-auto"><img alt="Close modal" src="/themes/amvuttra/src/images/0.0-icn-x-lg.svg"></button></p><div class="title">About mNIS+7 assessment<sup>1,3</sup></div><div class="image"><img src="/sites/default/files/2022-09/3.2_modified_neuropathy_impairment_score%2B7.svg" alt="Modified Neuropathy Impairment Score + 7 (mNIS+7) components" width="489" height="482" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><strong>Modified Neuropathy Impairment Score + 7 (mNIS+7)<sup>1,3</sup></strong></p><ul><li>Validated composite measure of motor, sensory, and autonomic neuropathy, with a score ranging from 0 (no impairment) to 304 points, with higher scores representing a greater severity of disease</li></ul></div></div></div></div></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --large_text"> <h2>48% of patients treated with AMVUTTRA experienced reversal in neuropathy impairment from baseline<sup>2,a-c</sup></h2> </div> <div class="sections__item --modal"><div class="title-toggler-container flex justify-between items-end lg:items-center mb-5"> <div class="title"> <span> Reversal in neuropathy impairment from baseline at 18 months<sup>a-c</sup> </span> </div> <p> <button class="toggle-modal open ml-auto"> <img src="/themes/amvuttra/src/images/magnifying-glass-icon.svg" alt="Open modal" /> <img src="/themes/amvuttra/src/images/magnify-hover.svg" alt="Open modal" /> </button> </p> </div> <div class="image"> <img src="/sites/default/files/2024-02/mNIS%2B7%20Reversal%20in%20Neuropathy%20Impairment%20from%20Baseline%20at%2018%20months%20graph.svg" alt="mNIS+7 Reversal in Neuropathy Impairment from Baseline at 18 months graph" loading="lazy" /> </div> <div class="body"> <p><sup>a</sup>Odds ratio: 22.9 (6.8, 76.9). </p><p><sup>b</sup>Percentages based on mITT population: AMVUTTRA (n=118); external placebo group (n=77).</p><p><sup>c</sup>Reversal defined as mNIS+7 change from baseline of <0 points. </p><p><sup>d</sup>95% CI: 39.3, 57.3.</p><p><sup>e</sup>95% CI: 0.0, 8.2.</p><p>mITT=modified intention-to-treat.</p> </div> <div class="modal"> <div class="modal-overlay"></div> <div class="inner flex flex-col"> <button class="toggle-modal close ml-auto"> <img src="/themes/amvuttra/src/images/0.0-icn-x-lg.svg" alt="Close modal" /> </button> <div class="title"> <span> Reversal in neuropathy impairment from baseline at 18 months<sup>a-c</sup> </span> </div> <div class="image"> <img src="/sites/default/files/2024-02/mNIS%2B7%20Reversal%20in%20Neuropathy%20Impairment%20from%20Baseline%20at%2018%20months%20graph.svg" alt="mNIS+7 Reversal in Neuropathy Impairment from Baseline at 18 months graph" loading="lazy" /> </div> <div class="body"> <p><sup>a</sup>Odds ratio: 22.9 (6.8, 76.9). </p><p><sup>b</sup>Percentages based on mITT population: AMVUTTRA (n=118); external placebo group (n=77).</p><p><sup>c</sup>Reversal defined as mNIS+7 change from baseline of <0 points. </p><p><sup>d</sup>95% CI: 39.3, 57.3.</p><p><sup>e</sup>95% CI: 0.0, 8.2.</p><p>mITT=modified intention-to-treat.</p> </div> </div> </div> </div> <div class="sections__item --large_text"> <ul><li>For the 55 evaluable patients treated with AMVUTTRA who did not experience reversal in neuropathy impairment at 18 months, progression was slowed compared with the external placebo group (mean change of 11 points vs 30 points)<sup>4</sup></li></ul> </div> <div class="sections__item --callout_box"> <div class="large-text"> <div class="large-text__item"><p>AMVUTTRA demonstrated consistent neurologic benefits across all subgroups, including age, sex, V30M variant status, previous TTR stabilizer use, and disease stage.<sup>1,2</sup></p></div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --large_text"> <h2>AMVUTTRA significantly improved quality of life<sup>2</sup></h2><h3>AMVUTTRA helped to alleviate the burden of the disease, as measured by <span class="tool-tip tooltipstered" data-tooltip-content="#tooltip-norfolk">Norfolk QoL-DN</span><sup>1,2</sup></h3><p style="height:0px;margin:0px;" id="secondary"> </p><ul><li>Norfolk QoL-DN is a patient-reported assessment that evaluates the effects of neuropathy in domains such as physical functioning, activities of daily living, symptoms, and autonomic function (score range -4 to 136), with higher scores representing greater impairment<sup>1</sup></li></ul><div class="tooltip-templates"><div id="tooltip-norfolk"><strong>Norfolk QoL-DN</strong>=Norfolk Quality of Life-Diabetic Neuropathy.</div></div> </div> <div class="blocks__item --tab_panel_2"><div class="tabs" data-active-tab="1"> <div class="tab-link active" data-target="1"> <span class="tab-label"> Change from baseline in Norfolk QoL-DN score<sup>2,a-c</sup> </span> </div> <div class="tab-link" data-target="2"> <span class="tab-label"> About Norfolk QoL-DN assessment<sup>5-7</sup> </span> </div> </div> <div class="panels"> <div class="panel active" data-panel="1"> <div class="inner-container"> <div class="--custom_html_code"> <div class="html-code"> <div class="html-code__item"><div class="--modal"><div class="title-toggler-container flex justify-between items-end lg:items-center mb-5"><div class="title"> </div><p><button class="toggle-modal open ml-auto"><img alt="Open modal" src="/themes/amvuttra/src/images/magnifying-glass-icon.svg"> <img alt="Open modal" src="/themes/amvuttra/src/images/magnify-hover.svg"></button></p></div><div class="image"><img src="/sites/default/files/2024-02/3.2_Norfolk_Line_Graph-CHART_18mo_v6.svg" alt="Change in Norfolk QoL-DN from baseline at 18 months with AMVUTTRA® (vutrisiran) versus external placebo" width="777" height="371" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><sup>a</sup>Norfolk QoL-DN scores at baseline were 47.1 with AMVUTTRA and 55.5 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -21.0 (95% CI: -27.1, -14.9).<sup>2</sup></p></div><div class="modal"><div class="modal-overlay"> </div><div class="inner flex flex-col"><p><button class="toggle-modal close ml-auto"><img alt="Close modal" src="/themes/amvuttra/src/images/0.0-icn-x-lg.svg"></button></p><div class="title"><span>Change from baseline in Norfolk QoL-DN score<sup>2,a-c</sup></span></div><div class="image"><img src="/sites/default/files/2024-02/3.2_Norfolk_Line_Graph-CHART_18mo_v6.svg" alt="Change in Norfolk QoL-DN from baseline at 18 months with AMVUTTRA® (vutrisiran) versus external placebo" width="777" height="371" loading="lazy" typeof="foaf:Image"></div><div class="body footnotes"><p><sup>a</sup>Norfolk QoL-DN scores at baseline were 47.1 with AMVUTTRA and 55.5 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -21.0 (95% CI: -27.1, -14.9).<sup>2</sup></p></div></div></div></div></div> </div> </div> <div class="--large_text"> <div class="body footnotes"><p><sup>a</sup>Norfolk QoL-DN scores at baseline were 47.1 with AMVUTTRA and 55.5 with external placebo group.<sup>1,2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference -21.0 (95% CI: -27.1, -14.9).<sup>2</sup></p></div> </div> </div> </div> <div class="panel " data-panel="2"> <div class="inner-container"> <div class="--large_text"> <p><strong>Norfolk Quality of Life-Diabetic Neuropathy (Norfolk QoL-DN)<sup>5-7</sup></strong></p><ul><li>Patient questionnaire designed to capture the impact on a patient’s quality of life related to:<ul><li>Activities of daily living</li><li>Polyneuropathy symptoms</li><li>Autonomic function</li><li>Small fiber nerve function</li><li>Physical functioning/large fiber nerve function</li></ul></li><li>Score ranges from -4 to 136; higher score indicates worsening quality of life</li></ul><p> </p> </div> <div class="--large_text"> <p class="mb-15"><strong>Sample questions<sup>7</sup>:</strong></p><ul><li>Have you felt unsteady on your feet?</li><li>Have you had a problem walking down stairs?</li><li>Have you had a problem with bathing or showering?</li><li>Have you had a problem with dressing?</li><li>Were you limited in the kind of work or other activities you could perform?</li></ul> </div> </div> </div> </div> </div> <div class="blocks__item --callout_box"> <div class="large-text"> <div class="large-text__item"><p>57% of patients treated with AMVUTTRA experienced improvement in quality of life from baseline at 18 months, compared with 10% of patients in the external placebo group.<sup>2</sup></p></div> </div> </div> </div> </div> <div class="sections__item --large_text"> <h2>AMVUTTRA improved nutritional status<sup>2</sup></h2><h3>Only AMVUTTRA has been able to show an improvement from baseline in <span class="tool-tip tooltipstered" data-tooltip-content="#tooltip-mbmi">mBMI</span> after 1 dose.<sup>1,8-11</sup></h3><ul><li>Patients treated with AMVUTTRA experienced significant improvement in nutritional status from baseline at 18 months compared with placebo-treated patients, who experienced a decline (25.0 units, -115.7 units, respectively [p<0.001])<sup>2</sup></li></ul><div class="tooltip-templates"><div id="tooltip-mbmi"><strong>mBMI</strong>=modified Body Mass Index.</div></div> </div> <div class="sections__item --modal"><div class="title-toggler-container flex justify-between items-end lg:items-center mb-5"> <div class="title"> <span> <a name="mBMI">Change from baseline in mBMI<sup>11,a-c</sup></a> </span> </div> <p> <button class="toggle-modal open ml-auto"> <img src="/themes/amvuttra/src/images/magnifying-glass-icon.svg" alt="Open modal" /> <img src="/themes/amvuttra/src/images/magnify-hover.svg" alt="Open modal" /> </button> </p> </div> <div class="image"> <img src="/sites/default/files/2024-02/3.2-chart-change-from-baseline-mbmi.svg" alt="Graph about AMVUTTRA® (vutrisiran) and impact on nutritional status." loading="lazy" /> </div> <div class="body"> <p><sup>a</sup>Mean mBMI baseline was 1057.5 with AMVUTTRA and 989.9 with external placebo group.<sup>2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference 140.7 (95% CI: 108.4, 172.9).<sup>11</sup></p> </div> <div class="modal"> <div class="modal-overlay"></div> <div class="inner flex flex-col"> <button class="toggle-modal close ml-auto"> <img src="/themes/amvuttra/src/images/0.0-icn-x-lg.svg" alt="Close modal" /> </button> <div class="title"> <span> <a name="mBMI">Change from baseline in mBMI<sup>11,a-c</sup></a> </span> </div> <div class="image"> <img src="/sites/default/files/2024-02/3.2-chart-change-from-baseline-mbmi.svg" alt="Graph about AMVUTTRA® (vutrisiran) and impact on nutritional status." loading="lazy" /> </div> <div class="body"> <p><sup>a</sup>Mean mBMI baseline was 1057.5 with AMVUTTRA and 989.9 with external placebo group.<sup>2</sup></p><p><sup>b</sup>Bars represent SEM.</p><p><sup>c</sup>N=number of evaluable patients.</p><p><sup>d</sup>LS mean difference 140.7 (95% CI: 108.4, 172.9).<sup>11</sup></p> </div> </div> </div> </div> <div class="sections__item --callout_box"> <div class="large-text"> <div class="large-text__item"><p>56% of patients treated with AMVUTTRA experienced an improvement in mBMI from baseline at 18 months, compared with 7% of patients in the external placebo group.<sup>4</sup></p></div> </div> </div> <div class="sections__item --large_text"> <h3>About mBMI assessment<sup>1,12</sup>:</h3><ul><li>Nutritional status assessment based on body mass index and serum albumin (kg/m<sup>2</sup> x albumin [g/L])</li><li>Higher score indicates better nutritional status</li><li>mBMI is used as a tool to monitor disease progression and provide prognostic information, showing close correlation with duration of gastrointestinal disturbances, malabsorption, and functional capacity</li></ul> </div> <div class="sections__item --accordion"> <div class="title"> <div class="title__item">AMVUTTRA improved other key measures of disease burden</div> </div> <div class="accordion-items"> <div class="accordion-items__item --accordion_item"><div class="item"> <div class="header accordion-header flex justify-start items-center" tabindex="0" aria-label="Toggle accordion" aria-expanded="false"> <div class="arrow"> <img src="/themes/amvuttra/src/images/0.0-icn-horizontal-carrot-red.svg" alt="Toggle item"> </div> <div class="title"> Gait speed: 10-meter walk test (10MWT) </div> </div> <div class="body"> <div class="flex flex-col sm:flex-row"> <div class="blocks"> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-09/gait_speed.svg" alt="Sneaker icon" loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <ul><li>Patients treated with AMVUTTRA <strong>maintained a better gait speed</strong> from baseline at 18 months compared with those treated with placebo (-0.024 m/sec, -0.264 m/sec, respectively [p<0.001])<sup>2</sup></li></ul><h3>About 10MWT assessment<sup>1</sup>:</h3><ul><li>Measure of gait speed (m/sec)</li><li>A higher number indicates less disability/less impairment</li></ul> </div> </div> </div> </div> </div> </div> </div> </div> <div class="accordion-items__item --accordion_item"><div class="item"> <div class="header accordion-header flex justify-start items-center" tabindex="0" aria-label="Toggle accordion" aria-expanded="false"> <div class="arrow"> <img src="/themes/amvuttra/src/images/0.0-icn-horizontal-carrot-red.svg" alt="Toggle item"> </div> <div class="title"> Ability to perform everyday activities: Rasch-built Overall Disability Scale (R-ODS) </div> </div> <div class="body"> <div class="flex flex-col sm:flex-row"> <div class="blocks"> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-10/3-2-everday-activities_0.svg" alt="Sun icon" loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <ul><li>Patients treated with AMVUTTRA were <strong>better able to perform activities of daily living</strong> compared with placebo-treated patients (LS mean change from baseline at 18 months was -1.5 and -9.9, respectively [p<0.001])<sup>2</sup></li></ul><h3>R-ODS<sup>3,13</sup>:</h3><ul><li>24-item scale that evaluated patient-reported ability to perform activities of daily living such as eating, bathing, dressing, and standing</li><li>Score ranges from 0 to 48; higher score indicates less disability</li></ul> </div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2022-09/sample_question.svg" alt="Sample questions icon" loading="lazy" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <p class="mb-15"><strong>Sample questions<sup>13</sup>:</strong></p><p class="mb-15">Are you able to:</p><ul><li>Walk 1 flight of stairs?</li><li>Bend and pick up an object?</li><li>Take a shower?</li><li>Do the shopping?</li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --callout_box"> <div class="large-text"> <div class="large-text__item"><p>A US expert panel recommended AMVUTTRA as one of the first-line treatments for the polyneuropathy of hATTR amyloidosis.<sup>14</sup></p></div> </div> </div> <div class="sections__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="paragraphs"> <div class="paragraphs__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --gray_block"> <div class="media"> <div class="media__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="130" height="109.08" viewBox="0 0 130 109.08"> <image id="treatmentCenter_4x" data-name="treatmentCenter@4x" width="130" height="109.08" 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</svg> </div> </div> </div> </div> </div> <div class="title"> <div class="title__item">Find a treatment center</div> </div> <div class="text"> <div class="text__item"><div class="title">Find a treatment center</div><p>Locate a treatment center closest to your patients.</p></div> </div> <div class="link-icon"> <div class="link-icon__item --link_icon"><a class="link" href="/treatment-center-directory" title="View the directory" muted="muted"> View the directory <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" width="18.809" height="18.809" viewBox="0 0 18.809 18.809"> <g id="pin" transform="translate(0.87 -0.553)"> <path id="Path_32092" data-name="Path 32092" d="M0,0H18.809V18.809H0Z" transform="translate(-0.87 0.553)" fill="none"/> <g id="CTA_arrow" data-name="CTA arrow" transform="translate(6.13 3.552)"> <path id="Path" d="M0,0,5.334,6.141,0,12.282" fill="none" stroke="#e7004c" 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ac2bTM/IqOlDDJxpDGiAb2MiTmfS+5oDq9KKZZIOR6UZwwblqgbs6SG40JkIAmAklbeCoMDEk2hjRGNMiGWBFGYzANswjoFAjozkyjF0W0YK5AwJK6QVbIM+sNYGlIwJ1AOQoG0EiyMaQRokH2MtRLjle5v1q8kwQClpOkyVMmZFdypJtltVajQFDjxFjpIlCuggGtGMTOyDTPkEaIBslweUT/HfbKfNZje+jxr7ZGlGdas8F84dwtNANWjG8eGZC+D1K2UBPdLKf1vwLrFZTAplfuFb/b9y9BH8vGhxHhO9745cT3viXVGLJcREO3fNtWSaGwpqi3lA+BQEvOFqpAaJcLs9DNMhAzkED6CaRh4akwWimIMSSmg1ePnZCbbXPuSZTHpoiG92qs9FaZ9gopGLZozCOtSaMnYaXclsutZN8ZaXazXFs5/bgdAt0sp/X/AusVAgEKhhMQ6yqnnjjxOero3Wkf0sDf5lhC7KJhZNaErspjOKJFCoYuXRmkNN0Vsl7YiupRyHWSlBl6NVULNdGLonwrGEigCAIUDPnQpk+U3/2Dd+ZfdDnb372FoiGHjU7FtJyCIYe0/2GLjLJGbuf4Rz0RAz0IeKk75DLPdLN8gguPSIAEhMCPiF+9eKto636qKBwLJl8szm++zt49X1RaJj0Er6yqAX9bbaGoH3S2NIo6jb2nQZa6uaiS+z/0HQ5J+EMaiVEv9+vkpjRMhD8Cezo3irau3xb9h2AkX2N2lhdFdBniFwDdLBvTNCxIggngb8WD2z9b9IJuEAx/Ne9rCSbgXnTYKKDnUmUtG/wYcwj4wb3F4brWSyaIBlRcR1ijI9EUprlc1mmd3HxtFuA46Zl9d0ih8GRRnttMYWcJBDhYwXzpINOfTKkDy0ECphOgYPBvocnV85VEA4QFeNqMIfHt3OKfS7gxTBAN4dboeGoPyl6GtrAS/u/f7GwJKy2T0jn73Nl/N76m6v1+ZbLEwo5Dj/pFNe4+BYJxTcIClQEBCga1Rm6sPlW5t9YUY0gTRAPUUtihJPU1IhJWyEItl5vvL/CwC687vYqKCjH/jGlCCgbPrPAf/+mX/11sa/+ZZzxTblpOkmqrmtiDYEqjsBxlRwCeWh/b/TWlX9BOcLCOxOIZlzvdSt21JBpDmiAadHyUixINUiw0y7dyndxiMzKReWsNEAxnnDNT1NR6CwYYN7a+dGvR//G1VkImbgmEBjnEQDfLumkzfRJQI1BOK1WqEfGOlURjSBNEgzfV4u52BX1MCoaF8plWuekQMUGLoyW+qmD4/d4fiWcUpwJpKagtUQoEGxCekoCBBCgYgjdKEo0h0yoaArVeOQgGAPHrYcBwRClTowJBd4hsd7NcJ4cZuFCTAyheIgHDCFAwFN8gSTOGLHvRIAVDvWzuVrmltocBr/OceVM9hyRKNVxCHkGCXSA0ylkM9dUzgyTBuCRAAgYQwMJTWEdicLg3cGnwd2DZgm+X9Y+DpBlDlr1okG/5SrmlWjA0NNaJU6a5V1G3YKBACPy3lA+QQCIIlPNKlWE1UNKMIctaNIz0MkA0pDaMH18l5sw/xbV+YQsGull2Rc0bJJAqAhQM4TRn0owhy1o0yCZfLjf3n+DhvBOxpnLqaU2iYkyFaxmeavte0d7arEThC2F+wyVizuQLOMRgQeGeBFJMgIIhvMYNYgyZGTrglHGzvNjmdEPHtXIXDQt1QDUlzalNEz3tGLCmfSkOm+Di9aym95f1eKQpbc1ykEBUBLjwVPiksUquijvpzv49TpnjO9bmdEPHtZN1JJqgNFMrGjC98g1zGl2bAtbOMF4qJqBn4dIF38r6hOfshmII8hkSSCYBCgY97YZp5aoBPnRsIdLvWLn3NNjYp+d0qjR89BqW+PVL3yyqskuarhRvnn11Uc/yIRIggeQSoGDQ13YNcvaYamjv3W1fL6dF9dkw4lE0hEHRsDTQyzDjDZNcSwXnTS7dXK7PYAbExXP/wf6yusbnDRIggfQQKEUw4Ff0JfNvsS+2lB44IdQEU85Vw6G+gmWy2dOgCo/xnAnUTxrv2suAxae2td/v/KDL1YqTxohzZQ8DV4N0AcTLJJBSAqXOrkrz0tZhNjl81OCHmYqvi47+XfasYczfLLc2uWkP5W7ToB1wHBlMf8Nk12yxtLXKi5mbwPDrx8RvX/mB+I/N7xfopYDwYCABEkg3AQqGaNu3oVqtt8Gllziy3gaKhmjfC+25wS+D22JU+CNQymwJWPdiTYq7n/2QeOC56wSmXTGQAAmkjwAFQ/RtmhRjSNo0RP9uaM2xfnKNa/rP7v+J672gN/b3bBXYMAOjeeIFnHoZFCDjk4ChBNCT+Miu/xXY7smqDo2lLRLB9kkxhqRoCNauxsduOKXOtYw7D/3C9V6xNzDUgd4LbJaTp9NPeReNnooFyudIIEYCXHgqPvhJMYakaIjvHQk9Z8yacBua2N3RquQ8pJRCYawNPQ/Hex/OFwsaLxZzG1tKSZLPkkAoBIb3tYlj+/dl0xratHU0zdd7+sTRXS+PnuceVExrEBVNJ3ydVEw7RVRMmyYq6urEmNPV59XnpmnyMQVDvK2TFGNIioZ435NQcx8/vtI1vbbDT7ne03Gjrfspge13L08Rsye+TZw97QN0Ma0DNNPMIzD4hyfF8IED4tiutqwY+PPeLjH8bHdeHNWTo2KvZ9STm6pExXnSTbsUF2PnzRZj5s0VlaefJU6qS55negoGz6aO7CaMITHs6xc8jCHb/J4t9T5FQ6kEDXq+bmK1a2kO9GxyvafzBownt7X/LLvB0Gd+w0ViTsNSDl/ohF4maaP3YPCPT2cFwtAzu8Sx37waac3/fHBQ/HnDXgFxMSBO/P+qOHuiGPuXp4rKRWeIyvnzje+VQC9ka9v/DjyrCrAxTbCl+UvsUQzpzcPfSBXRgOzgGdI2DR4zKNaHVBTXZCgaXNEk78a46rGOhYZhk4pfc8eHQ7xI48kQYZZpUgOPPyKGNm8Tg7/cVnQPgm506NkYfnbTqJDIFRHV77zIqJ4ILjyl+20Iln4SjCEpGoK1qdGxq8Y5i4YO6XZUNdSOnSx6jh5SjV5UvFzjSSylfeYplwkaTxaFMvUPvZ7pFv2/ekwMPvFHcfRXewR+3Sct5IqII+IuUfWh00XV284VcQsICgbz3qQgxpA9gwftFYjEVwNFgx17gs/HjHVeArszgGh455z/JeqqmsSO1x4RmG2hu4cC6dN4MsEvnaaiwzah/+HHxdBDzyVSKHhhGbxnu8CWKyDGv/cyr0dCv0fBEDrSUBKEMaRq6OwvcCcNY5p6uXWpplFMPIqGYqgZ+ozbzAnVMTJUyxojw6JU2DDeCSPKUpxCqeKyjCdb22rEfLnsNo0nVcmlIx56FfoeekD0/cevjB16CJu0JSB6br5PjPvQeaLm8stExczmsLPJSw9eXeGkrZiAadWXzPtHGjUXA0/xGVW7Bpe/6+htaFXMqqhoFA1FYUvnQ/iDYA+YMont/KPXie2vPSx2dj5StNMXe9pu5xi+sIwnUaazTnk/jSfdYKXgOgwaMz+6QwysPWFMqKNasC04eTZ+iAk522GWOKl2vHI2uVMzh58+GHrvB4Zd+r71ZHbD8MX4D75HVL3pAuXyqUYsZeEp/F987+nfpRGzKuwi4zVUn6psDIlZL1PrTsvNqUWetOZeCPuYoiFsogam19mvZtNQVeHuGKp67ASxeMbl2Q0v6raD98splU8WZXEdBBGmFrXuXT3i++ECsWDKxaO9IUHSYVzzCGAIou8n/5Xtqg+zdGOXzc5Og4SPhcrF54gx02dq+fV+bPtWMZzJCPh9OLb7ZTG871AoMzis3oexy34iaj/+wdDEAwVDmG+ZvrQaxp+qnHhH7y67aEBPg9ZA0aAVrxmJqy5Qper7HMp2at3XspXD2OjOzseUlXGxRJyMJ+dMvoDdpMUCjfE5fGy71/ybOCqnK5Ya4Cth7DvnyOmNp4mqxYsind4IB0/4A5rbI4AhlqHt27JCYmjzjpLqCD6HN6wWYYgHCoZS37Tonm+smaecWWcMy2RTNCg3j/kRBweOCrcZFLpKf2bTMoEN0zrjMp5srn9rtgy66sh0wyEQ1jAEehLGvX1x5CJBhQIcO0FEWELi9du6xeAfficGnvh90UadpYgHLDz1yM6vFS3qsbT1+c3XcUhCpfFDimMbbvBM1cEYcrZ8AGNwXZ4PlnCToqEEeKY9OtAfvWiwGMDq1zKehNORHe3H16Ow7uvaW8aTmIEB48kFUy6xd9fpyprpKhLAr++eu+8S/Ws3Fm0LYMo0RcUqj0aDiBh34SXZTawSAr0sPf+5vigBYYmHcdc8Luquvsp3yIUrVY42Q+IOTDaGpGhI3OtkfoExAwMbjCf3dG4U2167n8aT5jeblhLCbuHIjWuLmg0Bw8XxH3mnGLe0xfcDqaXwGhLFkEb9KrluxSoh4Kiq/xetgW06YDCKqajV1ywVdZ+61rGUFAyOWBJz0WRjSIqGxLxG/gXtPtwnJk4qtAiHAyUVfwsuU3j8M3aJAeNJa/gCxpM72uH74dHIjCdhQInuVRpPujSQxsvoXei6+dbAH0QUSefsAY1VDpy01QMxvLJN9N57nxi452nlnhjMtuj9hnR61bpV1N90rc2W43XxzMs/Llqo4//MX807brMUuFJ8IBQCJhtDUjSE0sRmJAKbBqdQWzldSTQMDmecHg/l2nHjydPE2+esFDCebOv6bXZBq1AS90jEWrYbwmn+5L8WC065hMaTHrzCuIVf0Edu+HflD6CV57hrFit1u1vx07KHX4YJ198g6j55fBhnYP3vlXtmsN5Gx4U3ipobL8rpdThJvG3O50Rt1VTxWzlsFyS0zL6B9kFBgGmKa7IxJEWDpkaPI9n+viHHbCsrah2v2y+6rJxmj1byudX7AOPJPYeeFM+9dp+SqCklY/S0wKENNowXYuEslIMhPALoXcjcvjbrayBIquUqFuyMYP+A4QZsfQ/eJ+DwSdVtttXrMOm2r44O5SySU6RnTFwkNrywUgxI3yd+gYLBj1B09002hjw5OgzMSTeBvj5nv/yN0lmIaoARY1QBxpPw/fCRRfeLSxd8KzuUgFXzdAcMw2Do4kfP/LXAVDQMnTCURgAGfp2fuCGQYIBYmPKH78gx/ptGP3SllSI9T8Ot9JSNP8z2IGBaqUpAr0PnpX+fFRxW/FNqF4gPL/yJaHRw3GbFwZ6CIZeGGceqU+BdhpW1+WugaDDj/QitFLBrsIegK6fZn4/iHIaTGEe94pz/zP4Bc/JOGXY5LN8PP33+GnHvsyvEplfuFTAgYwhGAL+KD11xi7JjI0yZbHz8GxQLPpitngeIBwgslYCeiSOfvkt0rbp5NHrVmDqx/IzvSVF+yeg16yC7tDWHJCwcRu1hDKkaHH74tKg+GzQeRUNQYobH7+kp7G0IsnLaoUJnIZHW2DKevPzsdeKKs+8RZ035GxFF7wOGZjBt8983vSfb+4A1Nxj8CRy5bXX2I6XSjY5fzBN+8GHRcPt3bYZ7/vmUcwyIB/TGTFp/gxjz9qlKKDDDouPyawSGjBAgHP5q3lfzhAP+Xy1b8G0O0ykRjT5SEGPITIQrXlI0RP8uaM2xLzNQkD6GAVQ/vB39uwqej+sCyg3DyauX/EJcfOo3RPPE8yMpCownH33xRvEfm98vsLgPbC8Y8gngY3T4+i8rD0dgRgR+MUe9mmN+qZN9BodRjfeuzQ5ZqNQEwxXtSz+R9Q1hxYdwaJn999m/BxAMQcbOrTS4j4bAhHHTlDNyWMm4WfnhgBFpCBkQmOnR3YwhG6rnKnmFi8oYMihHa+EsDB9g4ay4jCfnNCwte+94EAywX8BHyS9kexdWf+y4cyO/yLyvRACGktVLL5BTWr/v2wboAcLQ0YScNjiz6T3ijQ0XiPFj4TiQwVQC1orDKuVzsGuQzkD0BPY06OEaW6puxpCqRjUoeJTGkEFBWQtnwXjyA2esjdx48u6tf1vWxpMweOy47DrfjxXaFbYL2fF46RGRIVwCcBLV8MPVSrYOEA5dH/lBnoEkBUO47aErNVXbLpdFCVt0lIuiQQfVmNNMqjFkUGzoWs01ngwijILmZcXPNZ7E8EU5GU9CMOBX6/Czx8fJLSZO+7rV78vaLmA8niE8Ai/m2NpYtg6wE1GZYQEDSRitMiSHQGO12uJV+LvkMIyqZQYFhyeS8/4olxTGkHbPkEkyhlSu6EhEy3jSWjjr2QM/FXu7n4jE9wOMJ7HB3mJB48UCwyhpDJZg8DN4xMdr4r9+dnTBpjSyiKtO1kqV019dKN4x50vSSdmMbFFgJ1I5f744/Pl/9hV0EA4ItC3JYjD+n8lYJvuQWjE7enfbHddpEQ3saVBrj0TFGuovdPIUxBgyM3QwUfXNLaxlPInhiyiNJ7FwlmU8+Zs9a5xUf24xE3WsKhhg2d/w0P+hYNDQupZgQNL7e7aI+5+7WuTO8MFwReN931OaXcEeBw0NpCnJKTVzlVN2MIakaFCmV+YR+3oLRQOQwBhSJTgY1ag8Zlwc/Op/92m3io8t/i/xlpmfkfWfo72M8Dy5rf1n4u5nP5T1/QCX2Un2/aAqGGC/gDF2uERmCI8A3p1cwWClDA+PEKlP7PmOdUlguAKzK1R8OlA4jGIz+sBEY0j2NBj9yhRXuEym3/HBEp2FOKaZhIuW8SR8P0RpPImZKPA8aRlPmmxg6tSOw/vasjYMfkMS+EjB9wLtF5woFn8NguHB7Z8VmALsFp5tv188/MJXxeCxE+vGwKcDhYMbseRdV/2xE5UxJEVD8t4hpRL3Ojh5CuIspKPXHH8NShVWjGQZT8L3A1znRmk8+dCOL2R9P8B40sFoSbEG0UQ77ofhn3zXPsDHCR8phnAJWIJBZQr0S91PivXPX1eUcMD6FuhNYjCXgGnGkBQN5r4rJZWs18HJU4krp5VUHhMfhuHk+878Xtbz5JKmKwVWwtQdMHwBw0kMX/z8ha/kjUvrzjtI+ip+GCgYghBVjxtEMFipdsherbu2fFC81rPDupQVc349DpYfB/QqMZhJIGsMqVg0GEPaQuh2DRQNNsJpOXUSDUG8v3X2v5gWFL71gPHkm2dfnV04C8aTCyZf7PtMGBEs40ksnAXjSQf/8WFkEzgNrFvg57iJgiEwVqUH8A5gSEKlh8GeIOwc/ufw7/MuqwxVQDgcvv6fRl1O5yXAk9gJmGYMSdEQ+yuhpwBuxpCq3fFpMYYMShfGk/D9AONJDF+ojicGzSc3PuZYw3jSWjgrTuPJ3rvXCaxb4BUoGLzoFH8PgmHDjs8XJRiQK97XJbOuLCiAinCASOy6+daCZ3khfgKmGUNSNMT/TmgpAY0hS8Nq+X6wjCejXDgLxpPWwllRGk8O/uFJkbnhAU9wFAyeeIq+aQkGCMhigt/S1hAOWP/DKwzes11ANDKYR0D1x0sUxpAUDea9H6GViMaQ4aDEsI61cBb+OEe5cJZlPKl74SwYPnZ/6ruewOCHYeIXV3rG4c3gBHQLBqtE9Td9xdePA0QjDSMtYubsTTKGpEdIc96L0EsCu4aa2qq8dGkMmYcj8AmMJy3Pkztee0TsPPSLSDxPPnPwToENgqW5/q2hL2d86Pqve86UqDh7YtYPA6dVBn5lPB/o6N0j13r5g/Qjcq1wW9WwakytOKV2gfj+79+elxZWrr147j8I1e5rtN2k274qOi/9e8+2hmdJOIpiW+fhjvUkiGdILJMNO62c0JxzXPIhRUPJCM1NIGsMOS3f9z+NIcNpL8t4EgaUGELY0f6o53z6cHIVAsaT2DADY7402Fww5ZKSlzdGl/TRDXtdiwjX0JO+/UV+RFwJFX+jsWaOwBY0QDAUs7Q1nG/Bzffh5atds8TaIpnb14oJ19/gGoc3oiUQxBhyf/cWu5BcGGZpOTwRJk3D0qIxZDQNgl96cRtPFrtwFrqi/ewYam+6TMBNMYMZBIoVDFbpq950gai58SLr1HHf960nBWxcGMwg0FgzX7kgHYUz35YqP6wQkT0NCpCSGsXLGFJ1dgTGW4P0TiSVVRjltownreELLJy1U3rzK9a4TbVMmJ5nLZyF6aLNk85XXjir6+bve2Yz/gsXcHEjT0LHb0J8DWdOeGXE1dczPeLoLvepy0ObT/hUsGcx/PTB7BBC0/4H826VKhisxOo+da0YbN3qObX2yI1rxZRHLrAe4T5GAvjbAj8y8PPiFw7173SKgt6GLU43gl6jaAhKLGHxYQxpt2sI6hmSoiF4o1sLZ8GAEgsL7eh4NDusEDylYE/A5TC23708RQ5f/LVYcMol9vHN0QQz//p9z48GDB/rPnnNaHweuBPoXvNvnkM87k9634EYsXp5YEH/3tO/K/ABCSP42TdkhynkOwKBwRA/gcnV85VEA4QFHITZ3hOKhvibMBklGOw/WiAaaAwZbdvB9wM2uI7ec+hJ8dxr9yn95y+llPjDYRlPwjfH/IaL8own4QGwf+1Gzyzqb7o2NXYMTj0BVuXHTJ9p7EJb6L2wftmFKRhQd9g31HzxXZ7DU3hHxr/n3cbysdqwHPaN1acq//Do6N2pza7Beh/LgXlZ1rFHzqCYPKU2r+5Beg7KyTNkHiQNJ+h9WDzj8uxmGU+2yXUDdA9fYCiqZ2i/FC7vELDER+j6h295WtBjzNv6hasBhbYkMXV08A+/yw4LoPv/z3u7BH4xqwT0rIw5bYaoXHSGqH7nRcYJJtsvR5Uq+capuWKFGPjNJtdeEniLzPzoDq4v4ktSf4TpE2VngZxBpRJ0GkNSNKi0QILjZLqdV7zEr08VuwYXZyEJJmJG0WE8iQ3diHs6N4qdnY8ptUexpV887aOjggEGbl6zJbLDEgnqkoZQ6HvoAc+Pnwo3eEXENiA2iSPirqwzpKq3nZt6m46JKz8uOjbc6IoIHkKHr25jb4MroWhumGIMydkT0bR3bLn09Q055l1X2eR43X4Rv4JNX5HRXuYknePXY+7CWfA8GfbCWdNrF8o83jOKBQZuXgHDEkkIED+Hr/+yeHXBldkudi8hVEx94CHxyKfvEq8t/qCA/QfESRoDepRg8OoV0DPFEC8B/K1Q/dvgYQxZciUoGkpGaHYCw8PDYnDgaEEhS1w5rSA9XiidgGU8+ZFF9wssnBWW58klM64aLVzfg/d5dtfj42H6sATEQucnj/sawIddd0AXfe83HhPtSz8hwC+NAQav8MfhFiDIOAXTjU5012EMqRIsY0hbXBhDlhwoGkpGaH4CvZnBgkIGcRbSWbjcakF6vBAuARhOvvu0W7MLZ71l5meUf2HYS4Fehln152Yv45dyz83uHz18NHJnSxw4si07fGJPM65zGDNaYiHsXgWVOkE8oOcBZUjbUtLw/lh9jfd0/v6HH1fBxDgaCcAYUjXAGNIWKBpsQHjqQgDGkPag6noWz6nYPtjT53k4BNAlCeNJ9D584Iy12WW7MVdfNeT2MvTcfZen8SOcOFmug1/r2SF+tv1acffWvxW/3HVLrMt2Q+wcuW216LjwRk9bDFUmpcaDYIEr5oHHHyk1KaOer73iw569DVnbBjnrhiE+AlljSMXsYQxpCxQNNiA8dSHgZgxZ4sppLrnxsi4CmPUCz5NXL/lFdhlkv2XO7b0MXlMssbbE+PdeNlr0p/Yed/oEmxb4fcCy3f+x+f0CniejtHFB70LHZdcJeCg0KaDXoesjP8iKGZPKVUpZVHobeu9176kqJW8+q0bABGNIzp5Qa6tEx3IzhsTKafAm6BcsY0iMuTOYQUBl4Sz4ZrCCXy9DzaeXWVGzzqj29xT8Ssn6lrA8T8LeYkHjxcqeJ0cTD3DQe/c6Tx8CAZLSFhVi5s89feL17sLePG2ZakwYvQ0QlxBFTmHgnqflEFb3aI+UUxxe00fAMoaM0zMkbRr0ta8xKdMY0pimCL0gEHJYNMsynoQbaQRYWefOmBhY/3vXvO29DL97+Xuuca0bWDTr0RdvFD965q/Fb/asCb33oWvVzcYLBosFuu0xVTMNAb0N4z50nmtVICb6f/WY633e0E8giDGkQ2lKHqKgaHCgmsZLNIZMY6vm1wnGk9bCWRfN/cfRm34zJnJ7GZ47+F+BvFWiF2pb+8/E3c9+SNz77Arx3MENJRlPwn6h4/JrBD7EDPEQqLn8xDCVUwn6H37C6TKvRUQgiDEknMjZQrPtPPApRUNgZMl8gMaQyWy3YkqNLsypdaePPtr3f//f6LH9wN7LsOnAj+1RlM8x1NW6d/Wo8aTDHyzPtCAYOj9xQ2p+tXtWVvHmsV27FWOGFw3upccum+2aIAxB0zZ7xLWyBt5oqJmrXKr2wplvLcoPu0SkaHABk7bLNIZMW4uq1QeGhF5d56X0MriVwDKefGjHF7LGk7/f+yPf4QsKBmeaf870Ot/QfLX6XW/zzGFgY6vnfd7UR6AxgGg41PeivSAcnrAT4bkzAS9jSOcn8q9axpD5V3lmOoGe/1zvWkT4ZcAaC1b402s/tQ5D21sLZ2H44ucvfCU7fGFPnILBTiT+c7wXXs6e+jf8Nv5ClmkJYMekOu26o3+XndJEeaHZfjHIOXsagtBKcFwYQw4fGy6oAT1DFiBJzQV8jIcees61PjB4s/wyvNz1R9GhMJPGNTGFGzCexPDFMy/fmRe7+5/XePaG5EXmSSQE8F5UXnqma17ovcL7xRAPgYZqtSEKl9lxJfU2UDTE0+ax5NpDz5CxcI8rU1i5u02dQ5lyDd6a6s7I+n5Q9d1RbJ0aq+eIJbOuHH0cazrQ6HEUh1EHWO3TK3AWhRcdvff8fLTk5u5gW0TRkAuIx+4Eug/3FdwM4hmyo79gfKwgPV4wh8DgE390LQxWsoTBmxXGVlRnF866/Ox1Wc+TWDhLtQvUSsNvP056srx43i2j0bCWAdZ0YDCTQO7QlVMJhzY/73SZ1yIgEKcxJHsaImhgU7Lo7XV22FLiymmmVI/lyCGArmOvxZyql701J3b+ITxPvn3OyqznyTAXzlo87SpRXz0jmxnK1/2p7+ZnzDOjCGCIwnMWxX/zR0RcDRanMSQ9QsbV6jHkO9DnLBrgLETFw5i1chqm9DGYTcCv63j8pe9TqgB8P2CD6+g9h54Uz712n9K7Yk8cwxKL5BoaVui6+VbPoRMrnq49jPwqzmtyTD6OxbAcC2LAxcpFC1zX+xh+tjs79TK3x8qAIpdFESxjSBio+wUPY8g2v2ed7lM0OFFJ6bXBwWNZY8iKMRV5NYSzEBipqQSsnBZkSEMlTcYJn4DX0ETVh04fNYBUzRl/pLBwFjaMke5of1S+M08KlT9ayOOtb7huNCss9OTVCzIaMeQD1LvqbeeKqnPPyxuaKcjmdiEwVbXv54+JwV9u81xKvODZlF2oXHyO6BXuQ0hHd7zgzTJlPEyqDowhVRYT9DCGbCumPhQNxVBL8DMwhpw4aXxeDbIrpx3Mt2jPi5BzgpXTKBpygBh66PVRrlx0WkmlRvtj6z96ROzp3Ci2vXa/5xomCyZfkrc8d2b1PSXlH+Th7LRSueQz1lSwZoqoPD/m9HPEBLmJ64WAR83eH2woS/FQefpZnriO7npRjLvQMwpvaiIAY0gV0YDsIfRtf7dhDOk+H9ujzBQNHnDSeAvGkHbRUOLKaWnElOg6+S3ZPG5pSyj1wzBV7sJZzx74qdjb/UTB8MWSmVeN5oeFs9CtHUUY/4UL5OJK1ziKha7+V0Rm8KDo6N0lho71ZItTW9UkJoybNipwrDJi9U9smOlRboabEFrwGurWZkObd1iYuI+YQFBjSJtoaCm2uBQNxZJL6HNOxpAhrJyWUBrpLPbQ5m2uFcMHQMcYNIYvYDwpxMrsKpk7OjB88ZRAL0Ou8aPX8tyuhQ54A70LE//1s6LqTRfkPQmhsE0Km7bu3xQIm7yI8uSNEy8Qs+vfmrfoV92nrhUV004RPTffF6s9hr2sus/H/MV0V9Hw571durNn+i4E4jKGpGhwaZC0XqYxZFpb9kS9hp4p8AI3erPqr7y7m0cjlnBgGU9i+KLipBMTtODEyctvRAlZjj6KqaQNP1yd17vwWs8O8dTe78uu3C2j8fwOXpL2GtjgJRP2GLPqz80+gh6HyvnzRceFN/olEcp9E37Jj5k7SwyK7Y71ceuBcIzMi6ESCGIMmRk6aM/b8gzZZr/hd37if7RfTN5PBQHLGNJemSArp8EYksFMApjK6LXWROUi/aLBIoMerMoxtdlTlEu3EycnwYB1L+577hOBBINVfuzhJfOhHZ8Xm1+5d/Ry1t7hBx8ePU/7wdh5p3pWEf42GOIhoOoZ0sX2obmYUlM0FEMt4c84eYbMGkMq1gvGkAxmEhja7j40gRJXvektsRQctgw6g10wDB7LiAee+6x4RtHA169sbV1PiYOZE86MsnYO0maiHMJJdceFXznUNWl1bJAz31TDq5kX7FFb7BdUzikaVCilLI6TZ0gaQ6ajkYc2bXWtCOwZgswgcE2oiBs6bRlgw1B/07WjdYNgWP/8dUX3LljVg9OzJU1XiivOvke878zvCbjazg0wskTeaQ922xB7fb3eOXtcnodLoGG8umiA0a8tLLSdK53SpkEJU7oi0RgyXe2ZWxuvMXAYtMURMGVRpy1D7U2XCQwZIFiCodjFt7D2xvTahWLBlEsEPGN6BQiwmi++S2RueMArGu+RgDYCjTXzlNPuDGmZbIoGZeTpiXhUOnlyCvQM6UQlWdeGny4weBqtAAza4ghejqZKLQ8cNmGowAqP77410GqdlkjAL7Y5DUtFUG+n8KzZ+88PaxVFVt3i3MOdtJunzOGDHXEWrazz9hO2uXA6C9cOmi3v18utKzee3zFFgx+hFN7vc3EnTc+QyW5sGBt6/aKHd7+oA8rk5Wiq1PJMWPmp0SRgrIgZD/ZgrQhYV9kk6irl7IqauaJO+mQI8gfXnqZ1jt4GLDHe963CfK04ad8PH+hMexWNrp+qkycXY0gMUbQGqSBFQxBaKYrr5OQpiGfI9t7ddg9jKaKTzKr4GUGOmT4z8or5rYFRSoFqbrwoz+cE1rbIXd+ilLSDPDv+3ReVtWgIwopxwycAY0gXQVCQGYwhbWK5RUZqLYjocYGGkB5w0nyrp6dw8Sr8+lINhwrHx1QfZTxNBIYPHPBMWYdTJ88M5U2dQxNwDW1CgD1F2g0isXAVg5kEojaGpGgw8z3QXqq+zEBBHpazkIIbDhccVk5ziMVLURIYPvCaa3ZeSxy7PhTCjaO/2hNCKoVJjLtm8ehsicK70V9xWzEz+pIwx3IjELUxJEVDub1hI/Xt7xtyrLmqsxCXldMc0+TFaAgc2/1yNBkp5oKVIr1sLBSTcYxW/a4LHa/HdZG/xOMiz3xtww2eQDyMIT2fy71J0ZBLo4yO3YwhLaMxFRRYOY3BHAJ/zvS5FmbsvOhnTgxu2uxanlJuwN+En++AUtIv5lmsSaEjvN5d2COoIx+mmWwCqn+3XWwfAvlroGhI9rtSUumdnDwFXTmtpALw4VAJeC0edFJt/nLooWbsktjQ5gIPdC4xg10e+5fqDm2CpVx87Ipp04p/2ONJL5fgHo/xVpkRiNIzJEVDmb1cudV1MoYsceW03OR5HDEB0xYPGt53SAuBykX5nhm1ZMJESSBBBKI0hqRoSNCLEXZRaQwZNlFz04vDR4OuX8lYZdK0YNpwiWl8WB69BKI0hqRo0NuWRqdOY0ijmyfRhYMRpK5guYzWlT7TLSTg5fXx5Lroh74KS1jeV0IwhlQGSNGgjCp9EWkMmZ421fmRLobScCZTzGO+z2A1S4boCXh5fYzLPXn0FMzOUdUYsrN/t1NFWpwuOl2jaHCiUkbXaAyZjsbW9ZEulo6fo6li0z1p4rhiH+VzJJBqAnCTrhIGh3tFV/8+e1TlGRQUDXZ0ZXZOY8gya/CIquvlaCqiIkSazeAf0r32hNdCaHHYy0TauAnJbHKgZbILehsoGhLSzrEXk8aQsTcBC0ACRhPwWwgtjjVNjAYWU+GmyIXYVEOnXDvIFigabEB46kJgyGWZbHqGdAHGyyTgQEDXcIxDVpFf8lsILY41TSKHkIAMZ9UvUS6lg5Mn5SVwOTyhjDmdETOZfseKqRrV4GF6hnREyItlRCDNwzHHdhX8Kh1t2bjWNBktAA/yCDRUz8k7dzspxRiSosGNahld73VY8TKIZ8gjA96rK5YRSla1TAkMbd6R2pp7efaMwz15akGHULHG6nlKqZRiDEnRoIQ43ZF6HVa8DLJMdieXyY79BSmXcWUvV9lxNsLRDXu1ZQ+bgjiD10qllYvOirNozNtGIApjSIoGG/RyPHUSDSU6CylHjLHW2W9cOS1j7qa5ykaj65454WdToPPF81updNyFl+jMnmkHJBCFMSRFQ8BGSWP0vl7nZbJV7RocjGrSiCnRdUrTmLtpjqwGf/O7RL8bXoXv+/ljrrerPnS66z3eiIdAFMaQFA3xtK1RuboZQ5a4cppRdWRhoiUwdp6+lSiHdu6MtjI+uQ3+cptPjOTe9qpb1dvOTW7FUlxy3caQFA0pfnmCVM3RGDKQs5BdQbJjXA0EvFwse60doKEo4qS6Wh3JZtMc2vy8trSDJtz34H3CxCGToPVwij/w+COedat+50VOj/FazAR0G0NSNMTcwKZk72TXUOLKaaZUrWzK4eVi2WvtAB2AdBpmHv3vF3UUuag0+x9+oqjngjz0eqYnSPTQ4vb+5GHXtMZds1gKw4mu93kjPgK6jSEpGuJrW6NydhINNIY0qol8C1MxrcE1TtSzDvwMM10LqnADv+xNsGuAAaTOWRMWiqO7ohdJfnWr/dvlVvG4N4xAicaQzX7VoWjwI1Qm92kMmfyGrmhqdK1EHF3oOh3/9Pznete6RnXjyI1rI8kq6qElVCrzrTtd64Z25fLkrnhivxHEGLKjv0CQLvWrAEWDH6EyuU9jyOQ3tJ/xYdS/zr16PkqlPfTQcyJO/wWZf/2+53h/qfXLff7YC6/knmo/Rt2O/eZV13xqP/5B13u8YQaBCZVTlApyqN/RqNhzHQqKBiW05RGJxpDJbmc/48Nj+6P13Dl23mxtQP98cFBkbo/ml769EhBfvd94zH5Z2zk+4MP72rSln5uwX93Qy1D1pgtyH+GxgQQmV89XKtWRoXbRf/SIPS5Fg50Iz50JONk10BjSmZWJV/3+mEc9Nl61eJFWTH3fejJy2wb0bhy64hat9XJKvO+/fu50OdRrqNvhz/+zZ5r1X/+C533eNINAY7X6lOeO3oLeBooGM5rR/FIM9B8tKCSNIQuQGH3Ba9pl1OsjYNz75KYqrby6bv5+ZMMU+Kh2fuIGgV6OqEP/2o1a62nVzcv2pebGi4ROA9eomaY5v+kTPb/7eVXf370l71yeeD7M4Qk7rjI+z3SXtuIlPUPG//JUzJzsWojhpw+63tN1o/LSM3UlnU0XXffd/7xGax5I3Pqoeo316yyEzuEYlbpBjNZ96lqdVWTaIRJorFEbnkCWQY0hKRpCbKikJ9XXN+RYhSCeIbv69zmmwYvREKhcdJprRvjwRDU2bhVi3NvebB1q2w+s3SS6Vt2sLX2M83dcdp2ncaC2zHMSxnAMnEmFGTC1sn3pJzzrht6i+psoGMLkrjut6rEThC5jSIoG3a2XoPSHh4fF4EDhEEVtVZNyLTp6dyvHZcTwCYyZN9cz0cE/Pu15P+ybVW96i/YhCpQZwqHzk58NvQsfMwk6LrwxspkSfvyPfPou0Xv3Or9ovvfRu3DkttXi8PLVvsMttTddximWvkTNi6DLGJKiwby2jrVEvZnC8doSnYXEWp9yy9zPGDJqF8zwGqh7iMJqYzhawq/mMH6NI432S66MdJaEVQ+/feaGB7ICqZheIzwDIZTlJHsu/ELd6veJ8e+9zC8a7xtIQJcx5BgD68oixUigJzMgJk/JXzcgiLMQ2jXE2HgjWWNanJunwjhcMFe/68JsT0AUZDAEk/01/oMNYvxH3inGLW1RNt7DMARWdcQiTV4GgVHUwy+PrEDa8DmBlSaxcFTVuee51hNDEMd27RZDm18Qg/ds90t69D5cRddcsWL0nAfJIpA1hjx4p1KhYQxp+zvvagxJ0aCEtHwiuRlDYuW0zv49viA6+zk84QtJc4TKRQtcRYPlgjlKj37o/ag4e22kH2LUE7/IM+IBASO+MafNEG4eMzGrBEaiccyKKPVVgAg4LgTuyiaFulprkLgJR5U8x3/hAjHh+htUojKOoQR0GUNSNBja4HEVy80YEiunqYiGweFeAWPI+uqZcVWh7POtXHyO6BXuzocGN22OfIy65tPLsj0AcTQOZjzENesh6vqGUc8JP/gwhySibjgN+VnGkHDg5Bc8PENusT9LmwY7kTI/dzOGLHHltDKnGm318cveyz9C/4bfRlsgmRvGxSvO5qqIkYMPkCHemUnrb6BgCMDM9Kg6jCEpGkxv9RjKR2PIGKCHnKWX8SF+jRZjRFdqEdHbUE4hSSIJdjBTNv6QLqJT9oLqMIakaEjZSxJGdWAMaQ82Ixn77bxzGkPm4YjlxM8/wsDG1sjLhd4GfJzKIeBXe+N93xONj38ja1Nhap1RTgxHNNz+XYGZLgzpIhDEM2R74XR5R2NIioZ0vSOh1MbLGFIlAxpDqlDSGwf+EbxCHEMUKM/ElR/3KlZq7k2++2vZjzAMTht+uFrABbNJAWIBZULvAqdUmtQy4ZalLoCPnUN9BctkUzSE2xzpTc3LGFKl1pYxpEpcxtFDAL8aMWXOLcQ1RIGPqGkfUDdGxV7HL/fc2SloC7hgnvKH73i2SbH5BXkuVyygTOxdCEIveXFhkF5VUaNU8I7+XfZ46Hpqtl9kT4OdCM8FjSHT8RL4DVH03ntfLBXFx8prYa1YChVSphBEbr/csdhT/aqbsuIBUxrxAY8qwJ8DxMwpm36SFTAUC1GRjz+fhuq5SoVwmR1X0NtA0aCEs/wiOa14Sc+QyXoPxl14ieeHaeCeaF1K59KbdNtXPcuWGzcpx+jZUVnUCeIBPhDwAa//j09nex/CNppEJnPQuQAAKzRJREFUeigPhMLUHXeKSbd901XMJIUvy1kcgem15yg/+HLXM/a4BaKBfhrsiHieJdB9uE9MnDQ+jwaNIfNwJOJk3IfOE1joyCnAmRHcJbv9MnZ6Jqxr+HBi3P/QFbck0qmSnQM+0OhFCBog7LAhYEYL1gYZPvCa9N64I3vNz0GTZVg6dt4scVLteAEfHZWnn8Vhhyw9/gMCDTVqPQ2IC2NI29/5FlzPDRQNuTR4PEqgt7dwDQrcVPUM2TO0fzQtHsRHoObyy1xFA0rV93//XyyiAXlj3B+LIcHtc5ID1mcIw90yhNR4ueWF2/POeEICgQk0BhANKsaQHJ4I3ATl8cBAn7NoqKucpgQAXsj6jx5RistI+gjgQ2T9GnXKBQaRWJsgroBeDnShJzWg7GEIhqTWn+U2n0DYxpAUDea3eSwlHBw8JoaPDRfkXaKzkIL0eEE/gZoPvsszk55/+4nnfd03IRwwth+lYWCpdYLNAHwwxDG0U2rZ+Xz5EQjTGJKiofzeH+Ua9zgskx3EWQhWTmOInwDGzL0M7TBuHmdvAwihjLBx8Cpn/CSPlwAzEeC4KXdapSllYzlIwIlAmMaQFA1OhHktSwDGkPZQ4spp9uR4HhEBPxfOcfc2AAM+wvgY46NsYkBPCHpEMBOBUxZNbCGWyY1AUGNIWzotuecUDbk0eJxHwMkY0lo5LS+iy4nLymkusXlZJwF0o3v9ijehtwH1x8cYH2XThiss74nWTAedbcW0SSBsAmEaQ1I0hN06KUrPzRiyxJXTUkQoWVXx623IfOtOYyqEj3PWxbF0ghRnwFRKeHKk98Q4W4F5l0ogTGNIioZSWyPFz9MYMl2N69fbgJkU8NtgSkCvA5wg4aMdpQdF9MhkexZkvvC9gBkoDCSQdAJhGUNSNCT9TdBcfhpDagYccfJ+vQ09N98nXs90R1wq7+zw0c6KB7m4EqY46nBBDXuFrIMmabMw5ZE7sz0LFAve7cK7ySIQxBjy1cwL9sqNeoakcyc7Gp7nEXDyDEljyDxEiTpBb0P/w08IN0+D8BKZuX1t9iNtWsXQ84DyY4Ow6f/VY9Jz4vPi2AuvCPSSBAnoTRjzF9PFmLmzRPXSCzgTIgg8xk0kgdqqqcrl7ujdJabWnZYbn6IhlwaP3Ql4GUPCgZNfoDGkH6Ho79d+/IPi8IbVrhnD7XTV298iqt4Urz2BawHljRMC4kSsY9u3iuFMRhzbtVv8OdN74oY8OrmuRoyZNzd7zeR65RWaJyQQIoHGmnnKqXV6LJPNngZljOUZ0csYUkU0WJ4hMeuCwQwC+GiOu+ZxMbB2k2uBjty4Vk5/TNYaBpiyiT9oFAWuzcobZUzA1nPgSaKz/0X7/dnyQr3cumjTYEfD8zwCNIbMw5Gak4lfXOnpgXH42e7sMEVqKsyKkAAJiCB2DQ64skMUFA0OZHgpnwCNIfN5pOEsOzNh9cc8q4JhioHHH/GMw5skQALJIVBZUatU2P09W53iteAiRYMTGl7LI9DTU7h4VRBjyMxQMCO1vMx5oo0AfCH4eV88csO/GzebQhsQJkwCKScQZO0gBxTsaXCAwksOBPoyAwVXg3iG7OjfVfA8L5hBoP6mr3gOU2A2RecnbjCjsCwFCZBAnARg08CehjhbICl59/cNORa1tnK643X7xc7+PfZLPDeEgMowBaYzdq262ZASsxgkQAIxEViKfDk8ERP9JGXb11c4PIHyBzGqebnrmSRVuazKimEKODbyCphpYZK3SK+y8h4JkIAzgTCGiikanNnyqo2A04qXJa6cZsuBp3ESwGwKP0+LRz59V+xLaMfJiHmTQNIJZIYOKlWhoXqOazyKBlc0vJFLwNkY8riznNx4bseHCp2FuEXl9RgIYJhi0m1f9bRvQLG6P/VdASdKDCRAAskj0Nm/W6nQVRV1rvEoGlzR8EYuASdjyBJXTstNnscGEMiu8eAzDROGkYeuuIXCwYD2KqYIg394spjH+EwKCHT17xODw/meUt2qVVfZ5HaLNg2uZHgjj4CbMWSJK6fl5cGT+AnAvqFu9fs8C0Lh4InH2JuwSTm8fLU4cpu7C3FjC8+ClUzgle7NymnUVbqvU8GeBmWM5R2RxpDl0/41V6zwNYykcEjW+4DZL7BJQYDTLhq1Jqv9wihtW9dvlZOZPjHrksExPkWDIxZedCJAY0gnKum8Vr/qJgqHFDQtVgPt/ORnC9YZgYCgcEhBAytWof/oEdHW/ZRibCFm1S9xjUvR4IqGN+wEaAxpJ5Luc5UZFexxMPcdgMEqHHO5LYNO4WBu24Vdsmf3/0Q5SY+p9BuRCEWDMkpGpDFkeb0DmFHR8MPVvlMxLeHAX67mvB9oi6zBqnTM5RV6br6PbsK9AKXgHnoZtrXfr1yT2fXnu8Vtww2KBjc8vF5AgMaQBUhSfyGIcMAv196716WeickVxHCEZb8AMecV4JdjysYfCrQxQ3oJoJdBddYEKMyZfIEbjDbcoGhww8PrBQRoDFmApCwuqAoHwMjc8ED2o4WPF0O0BKzhCHjv9Atjl83O9iJRMPiRSvb9VzMviGcO3qlcCQxNYCq9S2jFdYoGFzq87Eyg12HFS3qGdGaVpqtBhAM+WhhLpxOo6N6AzL9+X3RceKPAOiF+AS7DG27/LnsY/EAl/D6GJX790jcD1eKsqe/3it+KmxQNXoh4r4BAr8OKl4016p4hewbV3JgWZMwLsROAcGi8d63vrAoUFB8vjKlzuEJvs0GYdVx+jej9xmNKGU34wYcFZsYwpJ/AU23fE0EWC5xQOUXMbWxxA/OgdYOiwSLBvRIBJ9Hg0Z1VkGZn/4sF13ghWQTw0Rn/Bddxz9HKYEwdwxWHr/8yje1GqYRzgOGfIL0LJzdVicbHvyHGv/eycArAVIwm8Mtdt4gdhx4NVMbF01Z4xV9v3aRosEhwr0Sgr9d5mWyPaTp56e7v4boFeUASejLh+hsEfrWqhMF7tov2pZ+gXwAVWApxMDOi47LrlHsXYL8Ag8cxp5+jkDqjJJ1AMYIBC1Sd2bTMq+oUDV50eM+dQCbT73izofpUx+tOF2Gcw5B8AvjVil+v+BXrF9DrgNkVcDQ0vK/NLzrvOxDAuhHgB47Dz6oZmtbceBHtFxxYpvESbBh+/sJXAvcwgMX5b/g7LyR3yJtdVgT2NFgkuFcm4GgMOV5dNHT07lLOixHNJoBfr/gVi1+zKgGOhtrf9Lns+gecYaFCTGSXI4dYwLoRbo6a7ClVnC1XLV1/g6j71LX2WzxPIYGXu54RP/3TRwN5fbQwnDXlbzw9QMp4a6y42I/JPeExCagQgF1DTW3+r8vGmnkqj2bjdHKZbGVWSYiYnVkhrfEzi76v3GWO9Q8G7nlaVF+zVNRe8WFa8js0NHoWev7tJ8pCwUoC9iZ1n7yGTC0gKd5j5cpn9t1RVO8CsGBY4rxZH/MiBC+QW3IjUDTk0uCxEoGsMeS0fIcwU+tOU3oWkWgMqYwqURHxq7Zy8TniyI1rlbrPMWQBq//+tRspHnJaGjYL/Q8/EVgsoHdhwjeuEVVv8jdSzcmOhwkkgCHebQfvL1osoMpVFTXiHW/8sqgeO8GLwCr7TYoGOxGe+xLwMoZUMXRUieNbCEYwkgA+WI33nSUyt6/NrqaoUki7eBj/nneLipnNKo+mJg7sPPr+6+diYP3vlQSXveKwXWCPjZ1Kes7Ro9DRu1vsP7JF7O1+QhwZai+5cm+Z+Rnh82MPtgyt9owoGuxEeO5LwMsYUlUQQCn7vLC+5WAEMwlguAKzK6re/hblXgfUxBIP6H2AA6Lqd12Y6l/NsOno/5XsaSmiV8FqediS1H/9C2Unsqz6p3FvCYROiAQ526yzf3cgN9AqTFpm3+A3WwKWtiud0qJocKLCa74EYAxpt2toCGgMSdHgiznREdDrMOWRC7L+BDAEAVGgGuBVElvF2dKZ1PI3i7T0PlhCYfCJPwpMRS02cCiiWHJmPYcfTxnp8E6nQLDXWEEw4JFVchudMYELVqBosEhwH4gAjSED4SrryLB1wEc/86M7skIgCAxMLex99rGs7QMWWKpe9lZRtXhRonwOwKBxaNNWMdi6VcnNsxcfiIWaTy+jkyYvSIbeg0DAzDEYgsOuS7VXNszqKAoGeH/MmzGRWwaKhlwaPFYmQGNIZVSMKAnARgGeJI/97VbRvebfAhv5ASJcU2d+84DIiAdkD8REMfYvTxWVi84QVeeeZ0z3PHoShrZvy4qEoc07iqqn0wtDseBExdxrJgiEXDowemxp/pKXm2grOrzvrbBOnPYUDU5UeM2XAI0hfRExggMB+HXAYkmDHy9uOqGVJHoghp+VQxgCKzrelRURY/5iuhgzd1Z2BseY6TO1CwkYLx7bvy8rEI7tflkc+9P+oowYrTo57SkWnKiYdQ0+Etql/QHW1YmrB8GLCKZVXjLvH71Wr7Qehx3DCrk5DktYkSgaLBLcByLQ1+fsThqeIVW73WgMGQh5qiLD3gEbxEP/w48HHrawwzguIrrFoNguesWJxZswpHHSxHFi7LxZ4qTa8dnHMC1UNbye6RFHdx1fL2X4YIcYPtApXu8eKHmYwS//qg+dLsZ/8D2pNgT1Y2DifUsgHJJDDB39cqihf4+JxRwt05KmK8WbZ189eu5xAMHQIrctHnGytyga/AjxviOB4eFhMThwVFSNG5t3P4gxJAyAaAyZh6/sTizxMHx1m+i9976sw6cgBpN+wKyloo+KvaNRc0XF6EUDDtCrkCajTwOQllSEpAmE3MpiLaB3zPmSSu8CHlMWDIhM0QAKDEUR6M0MFoiGCeOmKacFi2GPpViV02HE5BOAzUN2EazrRXZhq1KmISaJBtbtqLz0zNRPLzW5TbBmQ0fvTrG/e4vIDL2aiB4EN54QC0tmXOXnFjr38UCCAQ9SNOTi43EgAj3SnfTkKbV5z8yqX5J37nWiOozhlQbvpY8AFsLCNvz1NjGwsVX0b/it9uGAKClaQmHc294sxl14SZRZl31euQKhQ85gONS/MxRHSXGChZHj/MkXi7OnfUC1Z8Eq7lZ5sFxubdYFlT1FgwolxnEkkOl2W/FyjtJYH5yWMJCAGwH0PtRcsSK7wegQAmJo8wsl+Tdwy0v3dThhqly0QFQvvSBR00V1c9GZfhoFgsULxo3TaxeK6RMWFttb+x2Z1korvSB7ioYgtBg3j4CbMWRj9Twl0TA43Cvg/ay+emZeujwhATuBEwJC3rnt+MqP8H0Q5rRGe57FnqMnoeK8pqxIgNEl7DYY9BKwe1HsGdqf+B4EixgEAv6mTpbO86bUzA0y9GAlkbuHcc8KubXKrahA0VAUNj4EAm7GkHi5xSE1RvCnTtGgxoqxThCwDCizV26XPhy2S+dJmzbL2Q3tcrbDy2L46YOBPFCeSDnYEYwXT55dnxUIY+edKsZMn8aehGAIA8e2CwQdbpYDFyqkB0IWCLmlgu3CmpGtK/dG0GOKhqDEGD+PgJMxJNSwaqAxpCopxvMiAP8P2HKD5WjJadpkbryjG07MrMB1SwjkxsHQAsLJdTVizLy5oqKuriC/3Pg8DodAmgUCjBYxRR0zzmBAHsQeLADd0MSClSdFg0WC+6II0BiyKGx8KAICWDjLGhoYd6FHhrKngiF+AqZ5UQyTSK5AaKyZF8VUcxg5omdhvdxK6lmwc6BosBPheSACNIYMhIuRSYAEJAEKhNBfA/QotI5sEAptctMSKBq0YC2fRGkMWT5tzZqSQDEE0ioQMNWxoXqunMUghxnkkGyj3CK0z9oo22KLbSumeQI/Q9EQGBkfyCVAY8hcGjwmgfImkGQvil4tF6NAQA8CxEHryB7HbXKLLVA0xIY+PRnTGDI9bcmakIAqAQoEVVLK8YwTCE4lp2hwosJrgQjQGDIQLkYmgUQRsJwkYSXHpCzUpAp4QuUUMbl6vvSDcKqYPnGhHGKYL6rHTlB9vJR4iRAIThWkaHCiwmuBCPT2DjrGx5xjlVXg6BnSER8vkkDkBCyBgHUY0uJm2YIYo0DAnF7L/qB15LjLKlfS9hQNSWsxA8s70OcsGoJ4hsQfq4gUvoEEWSQSiJ5AmgUCfrDUVU6LvAdh754OseO5fWLPrgNi1wv7xcGDXU/d/dAXU+USlKIh+v+rqctxcPCYGD42LCrGVOTVra5yat651wlWmdPk3MQrW94jgbIgkOskKW09CBq9KHq+G9s2/484sO/QqEDYt/+w6O8fsj9zzH4h6ecUDUlvQUPK3yOXyZ44aXxeaTBGKA7emXfN7QTdoRQNbnR4nQTUCeQKBKwkSzfL6uzcYkIg7Nr+imjbfVC8IoXCrhdfdYua+usUDalv4mgq2H24r0A0wKhINeDXDwMJkEAwAmkWCJYXxdqqpjAWalIGS4HgjYqiwZsP7yoScDKGhI0CjI+ODLX7poJ17RlIgATcCdidJKWpB8ESCFiHISI3y1nQ+LHT0zMohuSwwgvP7xc/+N4v3BuAd7IEKBr4IoRCwM0YEtOZVEQD4tAYMpSmYCIpIGAXCBhmSEuIWyD0ZQZEf9+Q6LMZcHe8mtgJDZG+GhQNkeJOb2ZuxpCY/9zW/ZRSxWkMqYSJkVJGIK0Cwe5FsU4OM0ytOy2S1rN6ENwEQiSFSGkmFA0pbdg4qkVjyDioM88kEcj1opgZOijS0oNgFwhRrcOAWVv4uwORMDhw1LEHIUnvRxLKStGQhFZKSBlpDJmQhmIxIyGQKxA6+ncpOTqLpGAlZmKCQIANFYZE0cPJEC0BioZoeac6NxpDprp5WTkPAmkVCHYvihhiiGIlx9weBAoEjxcvhlsUDTFAT2uWNIZMa8uyXhaBNHtRtAuEqNZhwLACFr3DGjaZ7n4xNHSUPQjWC2fgnqLBwEZJapFoDJnUlmO5nQhQIDhRKe2aXSD0yVkMw8PDpSXKpyMlQNEQKe70Z0ZjyPS3cRprCCdJmUFpmJjChZricrNMgZDG/ylCUDSks11jqxWNIWNDz4wVCaTZi2JcAqFXOkjqlcML2Pp6h0Qm06/YGoyWNAIUDUlrMcPLi18X9kDPkHYiPI+KQJoFApwk1VU2icnSi+KUmrmRrd1CgRDV22tmPhQNZrZLYksFT2tOIYhnSKfneY0E/AjASRKGGDp7d2f9H9DNsh8x//sUCP6Myi0GRUO5tbjm+tpds1rZBfEMielrXPHSIse9E4G0elFEXU11s+zUDrxWfgQoGsqvzbXX2MmuoUF2n6qGdvlLkaJBlVb646VVIFhOkhqkq/W4Fmqim+X0//8Ju4YUDWETZXrZVeMmThqfRwJuZVXDoT4uk63KKm3xLCdJPRhmkMul081yaS1sOUnCSo4UCKWx5NPHCVA08E0InQD+ONkDvMjhl9XgcK/9VsE5XO4ypJ+AJRAgEulmufT2tgQCevroRbF0nkzBmQBFgzMXXi2BgJsxZEP1XKVfjp39e0rInY+aSCCtAiHXiyKG4OJYqIkCwcQ3Pr1lomhIb9vGVjM3Y0gYeKl2N9MYMrbmKyljuxfFzNCB1CzUlCsQpk9cKAXCfIHpxLpDrpMkCgTdtJm+HwGKBj9CvF8UARpDFoUtUQ/ZBcKh/p3iyFB7ourgVlgTBALWYaCbZbcW4vW4CFA0xEU+5fnC8KoUY8gDma2S0OUpp5Sc6qVZINi9KMbRg0CBkJz/C+VeUoqGcn8DNNW/VGPItu6nBD5UUXT/akKQ2GTtXhR7hvanpgfBLhCimtprOUka6D+aXcmRPQiJ/e9R9gWnaCj7V0APADdjyGm1CwUEgUrY07lRnNm0TCUq4xRJwC4Q0uRFMW6BwHUYinwp+ZjRBCgajG6e5BbOzRiyuf6tyqJh04F1FA0hvgJpFgi5XhQnjJsWmXMwqweBAiHEF5VJGU2AosHo5kl24ZyMIWdMXKRcKRjVPXdwA4WDMrETEdPqRR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</a></div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> </div> </div> </div> <div id="references" id="block-referencesinefficacy" class="block-references"> <div class="container"> <div class="body"> <div class="body__item"><h2>References</h2> <ol> <li>AMVUTTRA Prescribing Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc.</li> <li>Adams D, Tournev IL, Taylor MS, et al. <em>Amyloid.</em> 2023;30(1):18-26.</li> <li>Adams D, Suhr OB, Dyck PJ, et al. <em>BMC Neurol.</em> 2017;17(1):181.</li> <li>Data on file. Alnylam Pharmaceuticals, Inc.</li> <li>Vinik EJ, Hayes R, Oglesby A, et al. <em>Diabetes Technol Ther.</em> 2005;7(3):497-508.</li> <li>Vinik EJ, Vinik AI, Paulson JF, et al. <em>J Peripher Nerv Syst.</em> 2014;19(2):104-114.</li> <li>Vinik EJ, Vinik AI. In: Farquhar I, Summers KH, Sorkin A, eds. The Value of Innovation: Impact on Health, Life Quality, Safety, and Regulatory Research. Bingley, UK: Emerald Group Publishing Ltd; 2007;16:29-52.</li> <li>TEGSEDI Prescribing Information. Waltham, MA: Akcea Therapeutics, Inc.</li> <li>ONPATTRO Prescribing Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc.</li> <li>WAINUA Prescribing Information. Wilmington, DE: AstraZeneca Pharmaceuticals LP.</li> <li>Obici L, Ajroud-Driss S, Lin KP, et al. <em>Neurol Ther.</em> 2023;12(1):1759-1775.</li> <li>Suhr OB, Danielsson A, Holmgren G, et al. <em>J Intern Med.</em> 1994;235(5):479-485.</li> <li>van Nes SI, Vanhoutte EK, van Doorn PA, et al. <em>Neurology</em>. 2011;76(4):337-345.</li> <li>Karam C, Mauermann ML, Gonzalez-Duarte A, et al. <em>Muscle Nerve</em>. 2024;69(3):273-287.</li> </ol> </div> </div> </div> </div><div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> 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