CINXE.COM

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  <img class="media-element file-media-full" srcset="" alt="" title="" />  </picture></div> <p></p><div class="media media-element-container media-media-full _none"><div class="media-youtube-video media-element file-media-full media-youtube-1"> <iframe class="media-youtube-player" width="" height="" title="WALS: Biospecific Chemistry for Covalent Linking of Biomacromolecules" src="https://www.youtube.com/embed/hqf-eWWBU8Y?wmode=opaque&controls=&modestbranding=1&rel=0" name="WALS: Biospecific Chemistry for Covalent Linking of Biomacromolecules" frameborder="0" allowfullscreen="" id="WALS: Biospecific Chemistry for Covalent Linking of Biomacromolecules">Video of WALS: Biospecific Chemistry for Covalent Linking of Biomacromolecules</iframe> </div> <div class="field field-name-field-image-caption field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>NIH Director's WALS Lecture: Biospecific Chemistry for Covalent Linking of Biomacromolecules (9/18/2024)</p></div></div></div></div> <p><strong>Selected publications</strong></p> <ul> <li><strong>Biospecific chemistry for covalent linking of biomacromolecules</strong>.<br /> <em>Chem. Rev.</em> in press (2024), Open Access, DOI: <a href="https://doi.org/10.1021/acs.chemrev.4c00066">10.1021/acs.chemrev.4c00066</a><br /> Cao, L.; and Wang, L.</li> <li><strong>Genetically enabling phosphorus fluoride exchange click chemistry in proteins</strong>.<br /> <em>Chem</em> 10:1868-1884 (2024), Open Access, DOI: <a href="https://doi.org/10.1016/j.chempr.2024.02.010">10.1016/j.chempr.2024.02.010</a><br /> Cao, L.; Yu, B.; Li, S.; Zhang, P.; Li, Q.; and Wang, L.</li> <li><strong>Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects</strong>. <br /> <em>ACS Cent. Sci.</em> 9:1241-1251 (2023), DOI: <a href="https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00288">10.1021/acscentsci.3c00288</a> <br /> Klauser, P.C.; Chopra, S.; Cao, L.; Bobba, K.N.; Yu, B.; Seo, Y.; Chan, E.; Flavell, R.R.; Evans, M.J.; and Wang, L.</li> <li><strong>Genetically encoded chemical crosslinking of carbohydrate</strong>.<br /> <em>Nat. Chem.</em> 15:33-42 (2023), DOI: <a href="https://doi.org/10.1038/s41557-022-01059-z">10.1038/s41557-022-01059-z</a> <a href="https://rdcu.be/cXgml">PDF</a><br /> Li, S.; Wang, N.; Yu, B.; Sun, W.; and Wang, L.</li> <li><strong>Genetically encoded chemical crosslinking of RNA in vivo. </strong><br /> <em>Nat. Chem.</em> 15:21-32 (2023), <a href="https://doi.org/10.1038/s41557-022-01038-4">doi: 10.1038/s41557-022-01038-4</a> <a href="https://rdcu.be/cW2bZ">PDF</a><br /> Sun, W.; Wang, N.; Liu, H.; Yu, B.; Jin, L.; Ren, X.; Shen, Y.; and Wang, L.</li> <li><strong>Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants. </strong><br /> <em>Chem. </em>8: 2766-2783 (2022). <a href="https://pubmed.ncbi.nlm.nih.gov/35874165/">PubMed</a><br /> Yu, B.; Li, S.; Tabata, T.; Wang, N.; Cao, L.; Kumar, G. R.; Sun, W.; Liu, J.; Ott, M. M.; and Wang, L.</li> <li><strong>New Covalent Bonding Ability for Proteins.</strong> <br /> <em>Protein Sci. </em>31: 312-322 (2022). <a href="https://pubmed.ncbi.nlm.nih.gov/34761448/">PubMed</a><br /> Cao, L.; Wang, L.</li> <li><strong>Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics.</strong> <br /> <em>Cell</em>. 182(1): 85-97 (2020). <a href="https://pubmed.ncbi.nlm.nih.gov/32579975/">PubMed</a><br /> Li, Q., Chen, Q., Klauser, P. C., Li, M., Zheng, F., Wang, N., Li, X., Zhang, Q., Fu, X., Wang, Q., Xu, Y., Wang, L.</li> <li><strong>Genetically encoding fluorosulfate-L-tyrosine to react with lysine, histidine and tyrosine via SuFEx in protein in vivo.</strong><br /> <em>J. Am. Chem. Soc. </em>140(15):4995-4999 (2018). <a href="https://pubmed.ncbi.nlm.nih.gov/29601199">PubMed</a><br /> Wang, N., Yang, B., Fu, C., Zhu, H., Zheng, F., Kobayashi, J., Liu J., Li, S., Cheng, M., Wang, P. G., Wang, Q., Wang, L.</li> <li><strong>Spontaneous and specific chemical crosslinking in live cells to capture and identify protein interactions.</strong><br /> <em>Nat. Comm.</em> 8:1-10 (2017). <a href="https://pubmed.ncbi.nlm.nih.gov/29269770">PubMed</a><br /> Yang, B., Tang, S., Ma, C., Li, S. T., Shao, G. C., Dang, B., DeGrado, W. F., Dong, M. Q., Wang, P. G., Ding, S., Wang, L.</li> <li><strong>Site-specific incorporation of phosphotyrosine using an expanded genetic code.</strong><br /> <em>Nat. Chem. Biol.</em> 13:842-844 (2017). <a href="https://pubmed.ncbi.nlm.nih.gov/28604697">PubMed</a><br /> Hoppmann, C., Wong, A., Yang, B., Li, S., Hunter, T., Shokat, K.M., and Wang, L.</li> <li><strong>Heritable expansion of the genetic code in mouse and zebrafish.</strong><br /> <em>Cell Research</em> 27:294-297 (2017). <a href="https://pubmed.ncbi.nlm.nih.gov/27934867">PubMed</a><br /> Chen, Y., Ma, J., Lu, W, Tian, M., Thauvin, M., Yuan, C., Volovitch, M., Wang, Q., Holst, J., Liu, M., Vriz, S., Ye, S., Wang, L., Li, D.</li> <li><strong>Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR.</strong><br /> <em>Cell</em>. 2013 Dec 5; 155(6):1258-69. <a href="https://pubmed.ncbi.nlm.nih.gov/24290358">PubMed</a><br /> Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L.</li> <li><strong>In vivo expression of a light-activatable potassium channel using unnatural amino acids.</strong><br /> <em>Neuron</em>. 2013 Oct 16; 80(2):358-70. <a href="https://pubmed.ncbi.nlm.nih.gov/24139041">PubMed</a><br /> Kang JY, Kawaguchi D, Coin I, Xiang Z, O'Leary DD, Slesinger PA, Wang L.</li> <li><strong>Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity.</strong><br /> <em>Nat. Methods.</em> 2013 Sep; 10(9):885-8. <a href="https://pubmed.ncbi.nlm.nih.gov/23913257">PubMed</a><br /> Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L.</li> <li><strong>RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites.</strong><br /> <em>Nat. Chem. Biol</em>. 2011 Nov; 7(11):779-86. <a href="https://pubmed.ncbi.nlm.nih.gov/21926996">PubMed</a><br /> Johnson DB, Xu J, Shen Z, Takimoto JK, Schultz MD, Schmitz RJ, Xiang Z, Ecker JR, Briggs SP, Wang L.</li> <li><strong>Genetically encoding unnatural amino acids for cellular and neuronal studies.</strong><br /> <em>Nat. 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