CINXE.COM

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block-system"> <div class="content"> <div id="node-5221" class="node node-page clearfix" about="/wang/about" typeof="sioc:Item foaf:Document"> <span property="dc:title" content="About" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><h2>Research overview</h2> <p class="eyecatching">We genetically encode unnatural amino acids in live cells and organisms to investigate biological processes in their natural settings and to develop new biotherapeutics.</p> <p>The Wang Lab has developed new methods for the expansion of the genetic code in a variety of cells and model organisms, including mammalian cells, stem cells, <em>C. elegans</em>, and embryonic mouse. A key development is the use of type-3 pol III promoters (e.g., H1 and U6) for expressing prokaryotic tRNA in eukaryotic cells, which has proven generally useful for code expansion in yeast, mammalian cells, and invertebrate and vertebrate animals. The lab team discovered that release factor one (RF1) is nonessential in <em>E. coli</em> and engineered autonomous bacteria capable of incorporating Uaas at multiple sites with high efficiency. By developing the concept of proximity-enabled bioreactivity, the Wang Lab designed and demonstrated that a new class of Uaas, the bioreactive Uaas, can be genetically encoded in live systems. These bioreactive Uaas enable novel covalent bonding abilities to be specifically introduced into proteins and biosystems, opening the door for new protein engineering, biological research, and therapeutic application in vivo.</p> <p>Combining chemistry with molecular and cell biology, we are designing and genetically encoding new amino acids for in vivo investigation of protein signalling and for the development of new biotherapeutics.</p> <h2>Why now</h2> <p>Proteins are the major workhorse for biology and thus implicated in various diseases. Expanding the genetic code to incorporate novel amino acids into proteins enables us to manipulate proteins at the atomic scale in their native habitat with new properties overcoming natural limit. This unprecedented precision and barrier-breaking power thus opens enormous possibilities to transform both basic biological research and therapeutics.</p> <h2>Why here</h2> <p>The work of the Wang Lab is well integrated into and supported by the special academic environment at UCSF, which focuses on biomedical sciences and health. Our research into protein signalling can reveal underlying mechanisms for pathological conditions, and research into biotherapeutics can lead to innovative drugs for diseases.</p> <h2>Lab team</h2> <p></p><div class="media media-element-container media-media-full _none"><picture class="media-element file-media-full">  <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_full/public/wang/media-browser/LabRetreat2019_2.JPG?itok=bJ6_NXRx&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_2x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=OqU8-ha0&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_3x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=UT0RFI8y&timestamp=1564527735 3x" media="(min-width: 1025px)"></source> <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_three_quarters/public/wang/media-browser/LabRetreat2019_2.JPG?itok=8SoOqv9p&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_2x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=OqU8-ha0&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_3x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=UT0RFI8y&timestamp=1564527735 3x" media="(min-width: 801px) and (max-width: 1024px)"></source> <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_full/public/wang/media-browser/LabRetreat2019_2.JPG?itok=bJ6_NXRx&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_2x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=OqU8-ha0&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_3x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=UT0RFI8y&timestamp=1564527735 3x" media="(min-width: 641px) and (max-width: 800px)"></source> <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_three_quarters/public/wang/media-browser/LabRetreat2019_2.JPG?itok=8SoOqv9p&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_1_5x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=Mank379Y&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_2x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=OqU8-ha0&timestamp=1564527735 3x" media="(min-width: 481px) and (max-width: 640px)"></source> <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_half/public/wang/media-browser/LabRetreat2019_2.JPG?itok=aiSOGzwp&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_full/public/wang/media-browser/LabRetreat2019_2.JPG?itok=bJ6_NXRx&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_1_5x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=Mank379Y&timestamp=1564527735 3x" media="(min-width: 431px) and (max-width: 480px)"></source> <source srcset="/sites/pharm.ucsf.edu/files/styles/lab_half/public/wang/media-browser/LabRetreat2019_2.JPG?itok=aiSOGzwp&timestamp=1564527735 1x, /sites/pharm.ucsf.edu/files/styles/lab_full/public/wang/media-browser/LabRetreat2019_2.JPG?itok=bJ6_NXRx&timestamp=1564527735 2x, /sites/pharm.ucsf.edu/files/styles/lab_1_5x/public/wang/media-browser/LabRetreat2019_2.JPG?itok=Mank379Y&timestamp=1564527735 3x" media="(min-width: 0px) and (max-width: 430px)"></source>    <img class="media-element file-media-full" srcset="" alt="group" title="" />  </picture></div> <p>The members of the Wang Lab have a wide breadth of expertise in organic chemistry, molecular biology, cell biology, and neuroscience. The Wang Lab encourages interdisciplinary collaboration, values innovative technology development, and pursues biological questions in depth.</p> <h2>Affiliations</h2> <p>We are also a member of the <a href="https://cvri.ucsf.edu/">Cardiovascular Research Institute</a> and the <a href="https://cancer.ucsf.edu">Helen Diller Family Comprehensive Cancer Center</a>.</p></div></div></div> </div> </div> </div> </div> </div> </div>  <div id="sidebar-first"> <div class="region region-sidebar-first"> <div id="block-domain-menu-block-main-menu" class="block block-domain-menu-block"> <div class="content"> <div class="skip primary"> <a href="#postnav">Skip primary navigation</a> </div> <div class="menu-block-wrapper menu-block-main-menu menu-name-5419a5c9ec036648e3415d4a69923ecd parent-mlid-0 menu-level-1"> <ul class="menu"><li class="first leaf menu-mlid-8216"><a href="/wang" tabindex="0">Home</a></li> <li class="leaf active-trail active menu-mlid-12501"><a href="/wang/about" class="active-trail active" tabindex="0">About</a></li> <li class="leaf menu-mlid-8226"><a href="/wang/people" tabindex="0">People</a></li> <li class="collapsed menu-mlid-8231"><a href="/wang/research" tabindex="0">Research</a></li> <li class="leaf menu-mlid-8236"><a href="/wang/publications" tabindex="0">Publications</a></li> <li class="leaf menu-mlid-394571"><a href="/wang/photos" tabindex="0">Photos</a></li> <li class="leaf menu-mlid-8256"><a href="/wang/news-media-coverage" tabindex="0">News</a></li> <li class="leaf menu-mlid-8251"><a href="/wang/open-positions" tabindex="0">Open Positions</a></li> <li class="leaf menu-mlid-8271"><a href="/wang/thanks" tabindex="0">Thanks</a></li> <li class="last leaf menu-mlid-8246"><a href="/wang/contact" tabindex="0">Contact Us</a></li> </ul></div> <span id="postnav"></span> </div> </div> </div> </div> </div>  </div>  </div>  </div>  <div role="complementary" class="footer-make-a-gift-and-quote"> <div class="footer-make-a-gift"> <a href="https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_GeneralGivingForm&Primary=Pharmacy">Make a gift</a> </div> </div> <div class="footer-wrapper-outer" role="contentinfo"> <div class="footer-wrapper-inner"> <div class="footer-site-names-and-disclaimer"> <div id="parent-1-name-wrapper"> <div id="parent-2-name"><a href="https://pharmchem.ucsf.edu">Department of Pharmaceutical Chemistry</a></div> <div id="parent-1-name"><a href="https://pharmacy.ucsf.edu/">School of Pharmacy</a></div> </div> </div> <div class="footer menu"> <div class="region region-footer"> <div id="block-menu-footer" class="block block-menu"> <h2>Footer Menu</h2> <div class="content"> <ul class="menu"><li class="first leaf"><a href="https://pharmacy.ucsf.edu/suggestions" tabindex="0">Suggestions</a></li> <li class="first leaf"><a href="https://pharmacy.ucsf.edu/support?reporturl=https%3A//pharm.ucsf.edu/wang/about" tabindex="0">Report a problem</a></li> <li class="leaf"><a href="/wang/./contact" tabindex="0">Contact us</a></li> <li class="first leaf"><a href="https://websites.ucsf.edu/digital-accessibility" tabindex="0">Accessibility</a></li> <li class="leaf"><a href="https://www.ucsf.edu/website-privacy-policy" tabindex="0">Privacy policy</a></li> <li class="leaf"><a href="https://websites.ucsf.edu/website-terms-use" tabindex="0">Terms of use</a></li> <li class="leaf"><a href="https://websites.ucsf.edu/azlist" tabindex="0">A-Z website list</a></li> <li class="last leaf"><a href="/saml_login?destination=wang/about" tabindex="0">Log in</a></li> </ul> </div> </div> </div> </div> <div class="footer-social"> <div class="item-list"><ul><li class="first"><a href="https://www.facebook.com/ucsfpharmacy" class="facebook">Facebook</a></li> <li><a href="https://www.youtube.com/user/ucsfpharmacy" class="youtube">YouTube</a></li> <li class="last"><a href="https://x.com/ucsfpharmacy" class="twitter">X</a></li> </ul></div> </div> <div class="copyright"> © 2002–2024 The Regents of the University of California </div> </div> </div> <script type="text/javascript" src="https://pharm.ucsf.edu/sites/pharm.ucsf.edu/files/advagg_js/js__GM3GJPR36rRIz0TRkjC5OQwrioSyN9aoYRivDhCO_AM__qAl84FcCv2jyN22yFGS5Oc85cjd9zKX6p_cFNLGhe-M__4ZDS9Hjb2g1wcZ1YiOr1dgMtxsu_rgENwwDfaK8O-58.js" async="async"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"3132ed34d6","applicationID":"70694961","transactionName":"YFRUNUpZDUdUUEddV1kedwJMUQxaGl1cUF1oQVcGXWcVXVBE","queueTime":15,"applicationTime":581,"atts":"TBNXQwJDHkk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>