Search results for: Edyta Ku艣mierz

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Ku艣mierz</title> <meta name="description" content="Search results for: Edyta Ku艣mierz"> <meta name="keywords" content="Edyta Ku艣mierz"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Edyta Ku艣mierz"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Edyta Ku艣mierz</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Biological Evaluation and Molecular Modeling Study of Thiosemicarbazide Derivatives as Bacterial Type IIA Topoisomerases Inhibitors</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pawe%C5%82%20St%C4%85czek">Pawe艂 St膮czek</a>, <a href="https://publications.waset.org/abstracts/search?q=Tomasz%20Plech"> Tomasz Plech</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Strzelczyk"> Aleksandra Strzelczyk</a>, <a href="https://publications.waset.org/abstracts/search?q=Katarzyna%20Dzitko"> Katarzyna Dzitko</a>, <a href="https://publications.waset.org/abstracts/search?q=Monika%20Wujec"> Monika Wujec</a>, <a href="https://publications.waset.org/abstracts/search?q=Edyta%20Ku%C5%9Bmierz"> Edyta Ku艣mierz</a>, <a href="https://publications.waset.org/abstracts/search?q=Piotr%20Paneth"> Piotr Paneth</a>, <a href="https://publications.waset.org/abstracts/search?q=Agata%20Paneth"> Agata Paneth</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this contribution, we will describe the inhibitory potency of nine thiosemicarbazide derivatives against bacterial type IIA topoisomerases, their antibacterial profile, and molecular modeling evaluation. We have found that one of the tested compounds, 4-benzoyl-1-(2-methyl-furan-3-ylcarbonyl) thiosemicarbazide, remarkably inhibits the activity of S. aureus DNA gyrase with the IC50 below 5 渭M. Besides, this compound displays antibacterial activity on Staphylococcus spp. and E. faecalis at non-cytotoxic concentrations in mammalian cells, with minimal inhibitory concentrations (MICs) values at 25 渭g/mL. Based on the enzymatic and molecular modeling studies we propose two factors, i.e. geometry of molecule and hydrophobic/hydrophilic balance as important molecular properties for developing thiosemicarbazide derivatives as potent Staphylococcus aureus DNA gyrase inhibitors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bioactivity" title="bioactivity">bioactivity</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20design" title=" drug design"> drug design</a>, <a href="https://publications.waset.org/abstracts/search?q=topoisomerase" title=" topoisomerase"> topoisomerase</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling" title=" molecular modeling"> molecular modeling</a> </p> <a href="https://publications.waset.org/abstracts/20179/biological-evaluation-and-molecular-modeling-study-of-thiosemicarbazide-derivatives-as-bacterial-type-iia-topoisomerases-inhibitors" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20179.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">569</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Evaluation and Selection of Construction Contractors by Polish Public Clients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kozik%20Renata">Kozik Renata</a>, <a href="https://publications.waset.org/abstracts/search?q=Le%C5%9Bniak%20Agnieszka"> Le艣niak Agnieszka</a>, <a href="https://publications.waset.org/abstracts/search?q=Plebankiewicz%20Edyta"> Plebankiewicz Edyta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Contracting authorities in the public sector are obligated to apply the principles provided for in the Polish law for the evaluation and selection of contractors. To analyze the methods of contractors, applied in practice by public clients, the notices of contract award results for construction works were analyzed. The analysis shows that the procedure selected more and more often is open to competitive bidding, where the assessment of the competence of contractors is not very precise, as well as non-competitive bidding, i.e. single source procurement. The share of procurement procedures, where the only criterion is price, is increasing. The solution to the problems existing here might be the introduction of one of the forms of pre-selection of contractors. The article also briefly discusses verification systems for companies applying for public contracts used in EU countries. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=certification" title="certification">certification</a>, <a href="https://publications.waset.org/abstracts/search?q=contractors%20selection" title=" contractors selection"> contractors selection</a>, <a href="https://publications.waset.org/abstracts/search?q=open%20tendering" title=" open tendering"> open tendering</a>, <a href="https://publications.waset.org/abstracts/search?q=public%20investors" title=" public investors"> public investors</a> </p> <a href="https://publications.waset.org/abstracts/26032/evaluation-and-selection-of-construction-contractors-by-polish-public-clients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26032.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">285</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Environmental and Formal Conditions for the Development of Blue-green Infrastructure (BGI) in the Cities of Central Europe on the Example of Poland</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Biela">Magdalena Biela</a>, <a href="https://publications.waset.org/abstracts/search?q=Marta%20Weber-Siwirska"> Marta Weber-Siwirska</a>, <a href="https://publications.waset.org/abstracts/search?q=Edyta%20Sierka"> Edyta Sierka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The current noticed trend in Central European countries, as in other regions of the world, is for people to migrate to cities. As a result, the urban population is to have reached 70% of the total by 2050. Due to this tendency, as well as taking high real estate prices and limited reserves of city green areas into consideration, the greenery and agricultural soil adjacent to cities is are to be devoted to housing projects, while city centres are expected to undergo partial depopulation. Urban heat islands and phenomena such as torrential rains may cause serious damage. They may even endanger the very life and health of the inhabitants. Due to these tangible effects of climate change, residents expect that local government takes action to develop green infrastructure (GI). The main purpose of our research has been to assess the degree of readiness on the part of the local government in Poland to develop BGI. A questionnaire using the CAWI method was prepared, and a survey was carried out. The target group were town hall employees in all 380 powiat cities and towns (380 county centres) in Poland. The form contained 14 questions covering, among others, actions taken to support the development of GI and ways of motivating residents to take such actions. 224 respondents replied to the questions. The results of the research show that 52% of the cities/towns have taken or intend to take measures to favour the development of green spaces. Currently, the installation of green roofs and living walls is are only carried out by 6 Polish cities, and a few more are at the stage of preparing appropriate regulations. The problem of rainwater retention is much more widespread. Among the municipalities declaring any activities for the benefit of GI, approximately 42% have decided to work on this problem. Over 19% of the respondents are planning an increase in the surface occupied by green areas, 14% - the installation of green roofs, and 12% - redevelopment of city greenery. It is optimistic that 67% of the respondents are willing to acquire knowledge about BGI by means of taking part in educational activities both at the national and international levels. There are many ways to help GI development. The most common type of support in the cities and towns surveyed is co-financing (35%), followed by full financing of projects (11%). About 15% of the cities declare only advisory support. Thus, the problem of GI in Central European cities is at the stage of initial development and requires advanced measures and implementation of both proven solutions applied in other European and world countries using the concept of Nature-based Solutions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=city%2Ftown" title="city/town">city/town</a>, <a href="https://publications.waset.org/abstracts/search?q=blue-green%20infrastructure" title=" blue-green infrastructure"> blue-green infrastructure</a>, <a href="https://publications.waset.org/abstracts/search?q=green%20roofs" title=" green roofs"> green roofs</a>, <a href="https://publications.waset.org/abstracts/search?q=climate%20change%20adaptation" title=" climate change adaptation"> climate change adaptation</a> </p> <a href="https://publications.waset.org/abstracts/147465/environmental-and-formal-conditions-for-the-development-of-blue-green-infrastructure-bgi-in-the-cities-of-central-europe-on-the-example-of-poland" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147465.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates 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Search results for: Edyta Ku艣mierz