Medicinal Chemistry | SPT Labtech

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>Medicinal Chemistry | SPT Labtech</title> <link rel="shortcut icon" href="https://www.sptlabtech.com/hubfs/Logos/spt-labtech-favicon.png"> <meta name="description" content="Medicinal chemistry stands as the cornerstone of modern drug discovery, blending the principles of chemistry and pharmacology to design, synthesize, and optimize compounds that can potentially become life-saving drugs.">  <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/template_assets/84186523818/1690761173406/SPT-Labtech-2021/SPT-Labtech-Theme-2021/css/main.css"> <script src="https://code.jquery.com/jquery-3.6.0.min.js" integrity="sha256-/xUj+3OJU5yExlq6GSYGSHk7tPXikynS7ogEvDej/m4=" crossorigin="anonymous"></script> <script src="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/js/select2.min.js"></script>  <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="Medicinal chemistry stands as the cornerstone of modern drug discovery, blending the principles of chemistry and pharmacology to design, synthesize, and optimize compounds that can potentially become life-saving drugs."> <meta property="og:title" content="Medicinal Chemistry | SPT Labtech"> <meta name="twitter:description" content="Medicinal chemistry stands as the cornerstone of modern drug discovery, blending the principles of chemistry and pharmacology to design, synthesize, and optimize compounds that can potentially become life-saving drugs."> <meta name="twitter:title" content="Medicinal Chemistry | SPT Labtech"> <script id="hs-search-input__valid-content-types" type="application/json"> [ "SITE_PAGE", "LANDING_PAGE", "BLOG_POST", "LISTING_PAGE", "KNOWLEDGE_ARTICLE", "HS_CASE_STUDY" ] </script> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/48986487992/1718355622882/module_48986487992_menu-section.min.css"> <link rel="stylesheet" href="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-2712622/1732567126476/module_-2712622_Site_Search_Input.min.css"> <link rel="stylesheet" href="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-2712624/1732567129016/module_-2712624_Site_Search_Results.min.css"> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/53208558468/1635426677576/module_53208558468_global_banner.min.css"> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/49540197155/1642693438631/module_49540197155_product_image_and__description.min.css"> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/76127708830/1655117434454/module_76127708830_Parallax_Image.min.css"> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/49540076202/1643122452769/module_49540076202_product_card_module.min.css"> <style> #hs_cos_wrapper_widget_1708430274090 hr { border:0 none; border-bottom-width:1px; border-bottom-style:solid; border-bottom-color:rgba(0,0,0,1.0); margin-left:auto; margin-right:auto; margin-top:60px; margin-bottom:10px; width:50%; } </style> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/114228936331/1683203485676/module_114228936331_Info_Cards.min.css"> <link rel="stylesheet" href="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/178599170471/1727256234165/module_178599170471_NEW_Global_Footer.min.css">  <style id="hs_editor_style" type="text/css"> #hs_cos_wrapper_widget_1708428468592 { display: block !important; padding-bottom: 60px !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1708430628119 { display: block !important; padding-bottom: 50px !important; padding-left: 20px !important; padding-right: 20px !important; padding-top: 60px !important } #hs_cos_wrapper_widget_1710265006637 { display: block !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1710265132569 { display: block !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1708430222740 { display: block !important; padding-top: 30px !important } #hs_cos_wrapper_widget_1708428468592 { display: block !important; padding-bottom: 60px !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1708430628119 { display: block !important; padding-bottom: 50px !important; padding-left: 20px !important; padding-right: 20px !important; padding-top: 60px !important } #hs_cos_wrapper_widget_1710265006637 { display: block !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1710265132569 { display: block !important; padding-left: 20px !important; padding-right: 20px !important } #hs_cos_wrapper_widget_1708430222740 { display: block !important; padding-top: 30px !important } .main_area-row-2-max-width-section-centering > .row-fluid { max-width: 1670px !important; margin-left: auto !important; margin-right: auto !important; } .main_area-row-7-max-width-section-centering > .row-fluid { max-width: 1670px !important; margin-left: auto !important; margin-right: auto !important; } /* HubSpot Styles (default) */ .main_area-row-2-margin { margin-top: 0px !important; } .main_area-row-2-padding { padding-top: 45px !important; padding-bottom: 20px !important; } .main_area-row-6-padding { padding-top: 10px !important; padding-bottom: 40px !important; } .main_area-row-7-padding { padding-top: 80px !important; padding-bottom: 80px !important; padding-left: 30px !important; padding-right: 30px !important; } .widget_1625497891256-hidden { display: block !important; } </style>  <script> var _hsp = window._hsp = window._hsp || []; _hsp.push(['addPrivacyConsentListener', function(consent) { if (consent.allowed || (consent.categories && consent.categories.analytics)) { (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create','UA-17436965-1','auto'); ga('send','pageview'); }}]); </script>   <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; if (!window._hsGoogleConsentRunOnce) { window._hsGoogleConsentRunOnce = true; gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); if (useGoogleConsentModeV2) { _hsp.push(['useGoogleConsentModeV2']) } else { _hsp.push(['addPrivacyConsentListener', function(consent){ var hasAnalyticsConsent = consent && (consent.allowed || (consent.categories && consent.categories.analytics)); var hasAdsConsent = consent && (consent.allowed || (consent.categories && consent.categories.advertisement)); gtag('consent', 'update', { 'ad_storage': hasAdsConsent ? 'granted' : 'denied', 'analytics_storage': hasAnalyticsConsent ? 'granted' : 'denied', 'ad_user_data': hasAdsConsent ? 'granted' : 'denied', 'ad_personalization': hasAdsConsent ? 'granted' : 'denied' }); }]); } } gtag('js', new Date()); gtag('set', 'developer_id.dZTQ1Zm', true); gtag('config', 'G-067NPSFSGT'); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-067NPSFSGT"></script>   <script> var _hsp = window._hsp = window._hsp || []; window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} var useGoogleConsentModeV2 = true; var waitForUpdateMillis = 1000; var hsLoadGtm = function loadGtm() { if(window._hsGtmLoadOnce) { return; } if (useGoogleConsentModeV2) { gtag('set','developer_id.dZTQ1Zm',true); gtag('consent', 'default', { 'ad_storage': 'denied', 'analytics_storage': 'denied', 'ad_user_data': 'denied', 'ad_personalization': 'denied', 'wait_for_update': waitForUpdateMillis }); _hsp.push(['useGoogleConsentModeV2']) } (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5GW3GJ9'); window._hsGtmLoadOnce = true; }; _hsp.push(['addPrivacyConsentListener', function(consent){ if(consent.allowed || (consent.categories && consent.categories.analytics)){ hsLoadGtm(); } }]); </script>  <link rel="canonical" href="https://www.sptlabtech.com/applications/medicinal-chemistry">  <script src="https://cdn.bioz.com/assets/bioz-w-api-2.5.min.js"></script>  <script type="text/javascript"> (function(c,l,a,r,i,t,y){ c[a]=c[a]||function(){(c[a].q=c[a].q||[]).push(arguments)}; t=l.createElement(r);t.async=1;t.src="https://www.clarity.ms/tag/"+i; y=l.getElementsByTagName(r)[0];y.parentNode.insertBefore(t,y); })(window, document, "clarity", "script", "b980n9j1zx"); </script> <meta name="facebook-domain-verification" content="6swjbfmhuvnpjm6cw3mf6etjmi0qkb"> <meta property="og:image" content="https://www.sptlabtech.com/hubfs/Med%20Chem%20Banner.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="800"> <meta property="og:image:alt" content="Med Chem"> <meta name="twitter:image" content="https://www.sptlabtech.com/hubfs/Med%20Chem%20Banner.png"> <meta name="twitter:image:alt" content="Med Chem"> <meta property="og:url" content="https://www.sptlabtech.com/applications/medicinal-chemistry"> <meta name="twitter:card" content="summary_large_image"> <meta http-equiv="content-language" content="en"> <meta name="generator" content="HubSpot"></head> <body onload="randombg()">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5GW3GJ9" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="body-wrapper hs-content-id-162901815155 hs-site-page page "> <div data-global-resource-path="SPT-Labtech-2021/SPT-Labtech-Theme-2021/templates/partials/header.html"> <header class="header"> <div class="container"> <a class="logo" href="/"> <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/logo.svg" alt="SPT Labtech"> </a> <div class="nav-outer"> <a href="javascript:void(0)" class="menuImage"> <span class="line1"></span> <span class="line2"></span> <span class="line3"></span> </a> <style> .srch-btn{position:absolute;right:1px;top:1px;background:url(//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/search-icon.svg) no-repeat center center;border:none;outline:none;cursor:pointer;font-size:0;width:40px;z-index:1;bottom:1px} </style>  <div class="menu iphonNav"> <ul class="nav-lt"> <li class="sub-menu"> <a href="javascript:void(0);">Applications</a> <ul class="applications sub-nav-outer"> <li class="nav1"> <span class="nav-hd"> <a href="https://www.sptlabtech.com/applications/genomics"> Genomics </a> </span> <ul> <li class="nav1-inr"> <div class="cmn-nav"> <a href="https://www.sptlabtech.com/applications/single-cell-genomics"> Single Cell </a> <a href="https://www.sptlabtech.com/applications/genomics/pcr-qpcr"> PCR and qPCR </a> <a href="https://www.sptlabtech.com/applications/genomics/automated-ngs-library-preparation"> NGS Library Preparation </a> <a href="/applications/genomics#synthetic-biology"> Synthetic Biology </a> <a href="https://www.sptlabtech.com/applications/genomics/transcriptomics"> Transcriptomics </a> <a href="/applications/genomics#pathogen-surveillance"> Pathogen Surveillance </a> <a href="/applications/genomics#microbiome-metagenomics"> Microbiome & Metagenomics </a> </div> </li> </ul> </li> <li class="nav1"> <span class="nav-hd"> <a href="https://www.sptlabtech.com/applications/drug-discovery"> Drug Discovery </a> </span> <ul> <li class="nav1-inr"> <div class="cmn-nav"> <a href="/applications/drug-discovery#assay-development"> Automated Assay Development </a> <a href="/applications/drug-discovery#assay-setup"> Assay Setup </a> <a href="/applications/drug-discovery/3d-cells"> 3D Cell Culture </a> <a href="https://www.sptlabtech.com/applications/medicinal-chemistry"> Medicinal Chemistry </a> <a href="https://www.sptlabtech.com/applications/drug-discovery/chemical-crystallization"> Chemical Crystallization </a> <a href="https://www.sptlabtech.com/applications/proteomics"> Proteomics </a> <a href="/applications/drug-discovery#functional-genomics"> Functional Genomics </a> <a href="https://www.sptlabtech.com/applications/design-of-experiments-doe"> Design of Experiments (DOE) </a> <a href="https://www.sptlabtech.com/applications/dna-encoded-library-del-screening"> DNA-Encoded Library (DEL) Screening </a> </div> </li> </ul> </li> <li class="nav1"> <span class="nav-hd"> <a href="https://www.sptlabtech.com/applications/structural-biology"> Structural Biology </a> </span> <ul> <li class="nav1-inr"> <div class="cmn-nav"> <a href="/applications/structural-biology/cryo-em"> Cryo-EM </a> <a href="/applications/structural-biology#electron-microscopy"> Electron Microscopy </a> <a href="/applications/structural-biology#protein-crystallography"> Protein Crystallography </a> </div> </li> </ul> </li> <li class="nav1"> <span class="nav-hd"> <a href="https://www.sptlabtech.com/applications/sample-management"> Sample Management </a> </span> <ul> <li class="nav1-inr"> <div class="cmn-nav"> <a href="/applications/sample-management#tube-sorting"> Tube Processing </a> <a href="/applications/sample-management#compound-management"> Compound Management </a> <a href="https://www.sptlabtech.com/applications/sample-management/automated-biobanking"> Automated Biobanking </a> </div> </li> </ul> </li> </ul> </li> <li class="sub-menu"> <a href="javascript:void(0);">Products</a> <ul class="products sub-nav-outer"> <div class="top-hd"> <a href="https://www.sptlabtech.com/products">Find a product that fits your needs <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/rt-arw3.svg" alt=""></a></div> <li class="nav2 wd1"> <span class="nav-heading nav-heading-with-link"> <a href="https://www.sptlabtech.com/liquid-handling"> Liquid Handling </a> </span> <ul> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/firefly" style="color:inherit"> <span class="nav-hd2">firefly</span> <span class="nav-desc">Accelerate genomic research with innovative all-in-one, compact liquid handling</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/mosquito" style="color:inherit"> <span class="nav-hd2">mosquito</span> <span class="nav-desc">Nanolitre liquid handling technology performs ‘traditional’ tasks at a fraction of the volume, and higher speeds</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/dragonfly" style="color:inherit"> <span class="nav-hd2">dragonfly</span> <span class="nav-desc">Delivers accurate and repeatable nanolitre to milliliter dispensing</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/apricot" style="color:inherit"> <span class="nav-hd2">apricot</span> <span class="nav-desc">Automated liquid handling instrumentation for convenient general use across your entire team</span> </a> </li> </ul> </li> <li class="nav2 wd2"> <span class="nav-heading nav-heading-with-link"> <a href="https://www.sptlabtech.com/sample-preparation"> Sample Preparation </a> </span> <ul> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/chameleon" style="color:inherit"> <span class="nav-hd2">chameleon</span> <span class="nav-desc">Automated consistent application of samples to high-quality foil grids for cryo-EM</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/quantifoil" style="color:inherit"> <span class="nav-hd2">Quantifoil</span> <span class="nav-desc">Market-leading sample supports enable cryo-EM researchers to optimize data quality</span> </a> </li> </ul> </li> <li class="nav2 wd1"> <span class="nav-heading nav-heading-with-link"> <a href="https://www.sptlabtech.com/sample-management"> Sample Management </a> </span> <ul> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/compound" style="color:inherit"> <span class="nav-hd2">comPOUND</span> <span class="nav-desc">A scalable, reliable, and secure compound management solution</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/biomicrolab" style="color:inherit"> <span class="nav-hd2">BioMicroLab</span> <span class="nav-desc">Easy-to-use sample management automation instruments</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/arktic" style="color:inherit"> <span class="nav-hd2">arktic</span> <span class="nav-desc">Robust biospecimen storage and management down to -80°C</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/lab2lab" style="color:inherit"> <span class="nav-hd2">lab2lab</span> <span class="nav-desc">Novel sample and data transfer network system</span> </a> </li> <li class="nav2-inr"> <a class="cmn-nav2" href="https://www.sptlabtech.com/products/compact" style="color:inherit"> <span class="nav-hd2">comPACT</span> <span class="nav-desc">Reliable and efficient -20°C storage and retrieval has never been more accessible</span> </a> </li> </ul> </li> </ul> </li> <li class="sub-menu"> <a href="javascript:void(0);">About</a> <ul class="about sub-nav-outer"> <li class="nav3"> <a class="abt-link1" href="https://www.sptlabtech.com/company"> <span class="nav-hd3">Company</span> <span class="nav-desc3">With a focus on liquid handling, sample preparation and sample management, our expert teams create state-of-the-art solutions that scientists and researchers can trust</span> </a> <a class="abt-link1" href="https://www.sptlabtech.com/culture"> <span class="nav-hd3">Culture</span> <span class="nav-desc3">We have one overarching mission: to work together to accelerate life science research. Through our innovative solutions and state-of-the-art tools, we believe we can make a real difference to human health</span> </a> <a class="abt-link1" href="https://www.sptlabtech.com/spt-partners"> <span class="nav-hd3">Partners</span> <span class="nav-desc3">Collaboration is key in our mission to make a real difference to human health. Partnering with application leaders globally, we co-create to solve new challenges across the life sciences.</span> </a> <a class="abt-link1" href="https://www.sptlabtech.com/innovation"> <span class="nav-hd3">Innovation</span> <span class="nav-desc3">From the initial prototype through to manufacturing, installation and beyond, we bring a problem-solving mindset and technical expertise to drive innovation</span> </a> </li> <li class="nav4"> <a class="link1" href="https://www.sptlabtech.com/executive-leadership"> <span class="nav-hd3">Executive Leadership</span> <span class="img-block"> <img src="https://www.sptlabtech.com/hubfs/C%20Suite%20Leadership.jpg" alt="C Suite Leadership" loading="lazy"> </span> <span class="nav-hd4"></span> <span class="nav-desc3">Through strategic guidance, visionary thinking, and a relentless pursuit of excellence, our senior executives steer SPT Labtech towards achieving its mission of making a real difference to human health through solving advanced laboratory challenges.</span> <span class="link1">Learn more <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""></span> </a> </li> <li class="nav4"> <a href="https://www.sptlabtech.com/innovation" class="link2"> View all<img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""> </a> <a class="link1" href="https://www.sptlabtech.com/board-of-directors"> <span class="nav-hd3">Board of Directors</span> <span class="img-block"> <img src="https://www.sptlabtech.com/hubfs/Board%20Members.jpg" alt="Board Members" loading="lazy"> </span> <span class="nav-hd4"></span> <span class="nav-desc3">Our Board of Directors are committed to driving the long-term success and sustainability of SPT Labtech, providing expert guidance and oversight to execute the company’s ambitious commercial strategy.</span> <span class="link1">Learn more <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""></span> </a> </li> </ul> </li> <li class="sub-menu"> <a href="javascript:void(0);">Knowledge Base</a> <ul class="knowledge-base sub-nav-outer"> <li class="nav5"> <a href="/resources" class="abt-link1"> <span class="nav-hd3">Resources</span> <span class="nav-desc3">Our wide range of insightful resources include videos, whitepapers, eBooks, application notes and more</span> </a> <a href="https://www.sptlabtech.com/events" class="abt-link1"> <span class="nav-hd3">Events & Webinars</span> <span class="nav-desc3">Meet the SPT team at events all over the globe and virtually via our webinars</span> </a> <a href="https://www.sptlabtech.com/labtechunplugged" class="abt-link1"> <span class="nav-hd3">Podcast</span> <span class="nav-desc3">We chat with innovators and leaders from across the community to gain their unique insights.</span> </a> <a href="https://www.sptlabtech.com/news" class="abt-link1"> <span class="nav-hd3">News</span> <span class="nav-desc3">Latest news from SPT Labtech globally</span> </a> <a href="https://www.sptlabtech.com/blog" class="abt-link1"> <span class="nav-hd3">Blog</span> <span class="nav-desc3">Our latest blog posts feature trends in research, innovative techniques and new technology</span> </a> </li> <p class="blogCount d-none"> 10 </p> <li class="nav6"> <a class="link1" href="https://www.sptlabtech.com/blog/enhancing-usability-and-compliance-firefly"> <span class="date-block">31 October, 2024</span> <span class="img-block"> <img src="https://6586853.fs1.hubspotusercontent-na1.net/hub/6586853/hubfs/firefly%20software%20thumbnail.png?length=320&name=firefly%20software%20thumbnail.png" alt=""> </span> <span class="nav-desc3"> Enhancing usability and compliance: Latest updates to firefly® liquid handling software </span> <span class="link1" href="https://www.sptlabtech.com/blog/enhancing-usability-and-compliance-firefly">Continue reading <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""></span> </a> </li> <li class="nav6"> <a class="link1" href="https://www.sptlabtech.com/news/spt-labtech-and-ice-bioscience-launch-joint-automated-laboratory"> <span class="date-block">29 October, 2024</span> <span class="img-block"> <img src="https://6586853.fs1.hubspotusercontent-na1.net/hub/6586853/hubfs/5-1.jpg?length=320&name=5-1.jpg" alt=""> </span> <span class="nav-desc3"> SPT Labtech and ICE Bioscience Launch Joint Automated Laboratory in China for Intelligent Drug Screening </span> <span class="link1" href="https://www.sptlabtech.com/news/spt-labtech-and-ice-bioscience-launch-joint-automated-laboratory">Continue reading <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""></span> </a> </li> <li class="nav6"> <a class="link1" href="https://www.sptlabtech.com/news/spt-labtech-and-synthace-deliver-accessible-drug-discovery"> <span class="date-block">05 September, 2024</span> <span class="img-block"> <img src="https://6586853.fs1.hubspotusercontent-na1.net/hub/6586853/hubfs/dragonfly%20discovery%20and%20DOE.png?length=320&name=dragonfly%20discovery%20and%20DOE.png" alt="SPT Labtech and Synthace partner to accelerate drug discovery through accessible DOE"> </span> <span class="nav-desc3"> SPT Labtech and Synthace partner to accelerate drug discovery through accessible DOE </span> <span class="link1" href="https://www.sptlabtech.com/news/spt-labtech-and-synthace-deliver-accessible-drug-discovery">Continue reading <img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/arw-rt.png" alt=""></span> </a> </li> </ul> </li> <li class=""> <a href="https://apply.workable.com/spt-labtech/">Careers</a> </li> </ul> <ul class="nav-rt"> <li class="sub-menu"> <a href="javascript:void(0);">Support</a> <ul class="applications sub-nav-outer smaller-submenu"> <li class="nav1"> <span class="nav-hd"> Support </span> <ul> <li class="nav1-inr"> <div class="cmn-nav"> <a class="cmn-nav2" href="https://www.sptlabtech.com/reliance"> <span class="nav-hd2">reliance</span> <span class="nav-desc">Our reliance service provides access to a dedicated support team to safeguard your investment and secure your productivity.</span> </a> <a class="cmn-nav2" href="https://www.sptlabtech.com/product-help-center"> <span class="nav-hd2">Product Help Center</span> <span class="nav-desc">Our brand new Product Help Center is your one-stop resource for manuals, guides, and videos.</span> </a> </div> </li> </ul> </li> </ul> </li> <li class=""> <a href="https://store.sptlabtech.com/">Shop </a> </li> <li class="book-btn"><span id="hs_cos_wrapper_module_16240008250073_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_cta" style="" data-hs-cos-general-type="widget" data-hs-cos-type="cta"><span class="hs-cta-wrapper" id="hs-cta-wrapper-6a6c36c6-cfe0-4de5-ba19-c9d6334747be"><span class="hs-cta-node hs-cta-6a6c36c6-cfe0-4de5-ba19-c9d6334747be" id="hs-cta-6a6c36c6-cfe0-4de5-ba19-c9d6334747be"><a href="https://cta-redirect.hubspot.com/cta/redirect/6586853/6a6c36c6-cfe0-4de5-ba19-c9d6334747be"><img class="hs-cta-img" id="hs-cta-img-6a6c36c6-cfe0-4de5-ba19-c9d6334747be" style="border-width:0px;" src="https://no-cache.hubspot.com/cta/default/6586853/6a6c36c6-cfe0-4de5-ba19-c9d6334747be.png" alt="Product inquiry"></a></span><script charset="utf-8" src="/hs/cta/cta/current.js"></script><script type="text/javascript"> hbspt.cta._relativeUrls=true;hbspt.cta.load(6586853, '6a6c36c6-cfe0-4de5-ba19-c9d6334747be', {"useNewLoader":"true","region":"na1"}); </script></span></span></li> </ul> </div>  <div class="srch-block"> <a class="srch-icon" href="javascript:void(0);"><img src="//www.sptlabtech.com/hubfs/raw_assets/public/SPT-Labtech-2021/SPT-Labtech-Theme-2021/images/search-icon.svg" alt=""></a> <div class="seach-box"> <div id="hs_cos_wrapper_search_input" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="hs-search-field"> <div class="hs-search-field__bar"> <form data-hs-do-not-collect="true" action="/hs-search-results"> <input type="text" class="hs-search-field__input" name="term" autocomplete="off" aria-label="Search" placeholder="Search"> <input type="hidden" name="type" value="SITE_PAGE"> <input type="hidden" name="type" value="BLOG_POST"> </form> </div> <ul class="hs-search-field__suggestions"></ul> </div></div>  <div id="hs_cos_wrapper_search_results" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="hs-search-results"> <template class="hs-search-results__template"> <li> <a href="#" class="hs-search-results__title">Content Title</a> <p class="hs-search-results__description">Description</p> </li> </template> <ul id="hsresults" class="hs-search-results__listing"></ul> <div class="hs-search-results__pagination" data-search-path="/applications/medicinal-chemistry"> <a href="" class="hs-search-results__prev-page"></a> <a href="" class="hs-search-results__next-page"></a> </div> </div></div>  </div> </div> </div> </div> </header> </div> <div class="container-fluid m-0 p-0"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1629798268172" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="application-banner image" style="background-image: url('https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/08%20-%20Blog/goodbye-handpipetting.jpg')"> <div class="overlay"> <div class="grey-overlay"> <div class="container"> <div class="breadcrumb-container"> <ol class="breadcrumb custom-breadcrumb"> <li class="breadcrumb-item" data="1"><a href="/">Home</a></li> <li class="breadcrumb-item"> Drug Discovery </li> </ol> </div> </div> <div class="container"> <div class="flex"> <div class="application-bnr-text medium"> <div class="text-block"> <h1 class="title-symbol">Medicinal Chemistry</h1> <div id="hs_cos_wrapper_widget_1629798268172_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="banner_content.description"><p><span>Medicinal chemists manipulate molecules at the nanoscale level to create new and better therapeutics with enhanced efficacy and specificity. Incorporating automation into low volume workflows enables labs to meet the accuracy and throughput demands of modern drug discovery.</span></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module widget_1625497891256-hidden" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span id="hs_cos_wrapper_widget_1625497891256" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"></span> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-4 main_area-row-2-max-width-section-centering main_area-row-2-padding main_area-row-2-margin dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708428468592" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708428468592_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p>Medicinal chemistry is a multidisciplinary field at the intersection of chemistry, biology and pharmacology focused on the design, development, and optimization of biologically active compounds for therapeutic use. In the early stages of drug discovery, the focus is on the identification and synthesis of new chemical entities that can interact with specific biological targets. During the hit-to-lead optimization stage, the chemical structure of promising candidates is modified to enhance pharmacological properties, such as potency, selectivity, permeability, metabolic stability and solubility.</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430725766" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="download-and-book-block" id="download-and-book-block"> <div class="container bullet-list-points"> <div class="cta-download-block"> <div class="tab-content"> <div class="tab-pane in active"> <div class="product-detail-block"> <div class="product-img"> <img src="https://www.sptlabtech.com/hubfs/Med%20Chem%20mini%20banner.png" alt="Med Chem mini banner" loading="lazy" style="max-width: 100%; height: auto;"> </div> <div class="product-info"> <h2>Chemical Space Exploration</h2> <h2 id="singlecellingenomicsexplained" style="font-size: 48px;"></h2> <p>Exploration of chemical space is fundamental to the process of <a href="/applications/drug-discovery" rel="noopener">drug discovery</a>. It involves investigating the universe of both known and unknown molecules, as well as the synthetic transformations necessary for their production, and their relationships to each other. It is estimated that this vast chemical landscape contains over 10<sup>60</sup> drug-like compounds, any of which could potentially serve as a life-saving therapeutic agent.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430628119" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708430628119_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3><strong>Navigating the Chemical Space</strong></h3> <p>The challenge of exploring chemical space extends beyond its sheer size. Not all theoretically possible molecules can be synthesized easily, if at all. For those that can be synthesized, some may be highly unstable or reactive, making them difficult to isolate or study. AI and machine learning (ML) can help with navigating chemical space but the models they generate might be difficult to interpret.</p> <p>To overcome these challenges, there is a growing need to combine AI/ML models with <a href="https://pubs.acs.org/doi/10.1021/acs.oprd.9b00140" rel="noopener">high throughput experimentation (HTE)</a> to efficiently identify and validate novel compounds. In this hybrid approach, virtual screening is used to prioritize promising candidates, which are then experimentally validated through HTE. The data generated from HTE can be fed back into the virtual screening models, refining their predictions and real-world relevance in an iterative cycle. This process not only enhances the accuracy of models but also focuses exploration on the most promising regions of chemical space. Additionally, it enables rapid optimization of reaction conditions, significantly reducing the time and cost associated with the identification of novel drug candidates.</p> <p>Since the curation of AI/ML models heavily depends on large volumes of high-quality experimental results, ensuring the accuracy of this data is paramount. Automating HTE has become critical to preventing the introduction of noise, false positives, and false negatives.</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708428856139" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="block"> <img src="https://www.sptlabtech.com/hubfs/Med%20Chem%20mid%20banner%20(1).png" data-speed="-1.5" class="img-parallax"> </div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710265006637" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1710265006637_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p> </p> <h3><strong>Advancing Chemistry with High-Throughput Techniques</strong></h3> <p>In recent years, ultra-high throughput experimentation (uHTE) has emerged as a transformative approach. It significantly increases the number of data points generated per experiment, while simultaneously addressing the challenges associated with limited quantities of newly synthesized or rare compounds and the scarcity of substrates. Automated uHTE enables the simultaneous execution of over 1500 experiments at the nanomolar scale, significantly reducing material consumption and set-up time. This methodology accelerates the design-make-test learning cycle, enhancing efficiency in chemical exploration and compound optimization. Additionally, the reaction <a href="/blog/automation-miniaturization-solution-testing-research-bottlenecks" rel="noopener">miniaturization</a> supports sustainable practices by decreasing the volume of hazardous chemicals required and minimizing waste generation.</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710265132569" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1710265132569_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p style="font-size: 48px;"> </p> <h3><strong>Enhancing Reproducibility</strong></h3> <p>Ensuring consistency in HTE and uHTE experiments can be difficult due to the scale and speed of the process. Small variations in experimental conditions or human errors can lead to significant discrepancies in the results. These experiments often require precise pipetting of challenging solutions, such as metal catalysts or organic solvents, which are difficult to handle manually, especially when low volume transfers are needed. Advances in liquid handling technologies are addressing these issues effectively. <a href="https://www.sptlabtech.com/products/mosquito/mosquito-lv">mosquito LV</a>, a low volume pipettor that is agnostic to liquid viscosity, enables the automated execution of multi-parallel synthesis at the nanomolar scale, facilitating precise and highly reproducible investigations of reaction discovery and optimization. These reactions include Suzuki cross-couplings, reductive aminations, N-alkylations, nucleophilic aromatic substitutions (S<sub>N</sub>Ar), as well as transition-metal catalyzed couplings such as the Pd-catalyzed Buchwald-Hartwig amination, metallophotoredox C–N and C–O bond formations, and C–H functionalizations (<strong>ref 1-7</strong>)</p> <p><a href="https://www.sptlabtech.com/products/evx-96">Evaporex® (EVX) evaporators</a> seamlessly integrate into medicinal chemistry workflows, offering efficient solvent removal under controlled conditions, reducing well-to-well and plate-to-plate variability, and sample contamination risk. The instrument's high-throughput capabilities empower researchers to conduct large-scale screening experiments efficiently, accelerating the pace of drug discovery and development.</p> <h3><strong>Related products</strong></h3> <p>With a focus on liquid handling, sample preparation and sample management, our expert teams create state-of-the-art solutions that scientists and researchers can trust.</p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1628177031915" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="product-card-module anchor-point" id="product-card-module"> <div class="container bullet-list-points"> <div class="text-module bullet-list-points"> <h2></h2> </div> <div class="p-card-module-inr"> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>Evaporex<sup>®</sup></strong></h3> <p>Accelerate the discovery process with optimized microplate sample preparation</p> <p>EVX evaporators minimize low-volume sample drying time by evenly directing heated gas to microplates using dual upper and lower stainless steel needle assemblies. With full control over the temperature and flow rate, you can ensure optimum evaporation rate for your experiments for increased research productivity.</p> <a class="btn" href="https://www.sptlabtech.com/products/evx-96"> Explore Evaporex </a> </div> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=403&height=519&name=Evaporex%20192.png" alt="Evaporex 192" loading="lazy" width="403" height="519" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=202&height=260&name=Evaporex%20192.png 202w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=403&height=519&name=Evaporex%20192.png 403w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=605&height=779&name=Evaporex%20192.png 605w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=806&height=1038&name=Evaporex%20192.png 806w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=1008&height=1298&name=Evaporex%20192.png 1008w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/13%20Evaporex/Evaporex%20192.png?width=1209&height=1557&name=Evaporex%20192.png 1209w" sizes="(max-width: 403px) 100vw, 403px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=450&height=650&name=mosquito-product-LV---text-block-1.png" alt="mosquito-product-LV---text-block-1" loading="lazy" width="450" height="650" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=225&height=325&name=mosquito-product-LV---text-block-1.png 225w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=450&height=650&name=mosquito-product-LV---text-block-1.png 450w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=675&height=975&name=mosquito-product-LV---text-block-1.png 675w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=900&height=1300&name=mosquito-product-LV---text-block-1.png 900w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=1125&height=1625&name=mosquito-product-LV---text-block-1.png 1125w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/01%20-%20mosquito/03%20-%20mosquito%20LV/mosquito-product-LV---text-block-1.png?width=1350&height=1950&name=mosquito-product-LV---text-block-1.png 1350w" sizes="(max-width: 450px) 100vw, 450px"> </div> <div class="product-card-text pad-l75"> <h3><strong>mosquito<sup>®</sup></strong> LV </h3> <p>mosquito LV offers highly accurate and precise multichannel pipetting from 25 nL to 1.2 µL and simplifies assay miniaturization and compound handling workflows with automated, high throughput operation.</p> <p>The easy-to-use instrument enables significant time and reagent savings through low volume pipetting and ultra-low source dead volumes for a rapid return on research investment.</p> <a class="btn" href="https://www.sptlabtech.com/products/mosquito/mosquito-lv-genomics"> Explore mosquito LV </a> </div> </div> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>mosquito<sup>®</sup></strong> X1</h3> <p>mosquito X1 enables accurate and precise single-channel positive displacement pipetting from 25 nL to 1.2 μL (LV) or 500 nL to 5 μL (HV).</p> <p>With programmable sampling of any individual well in any plate, as well as multiple deck positions, mosquito X1 is ideally suited to rapidly cherry pick compounds from high throughput screening (HTS) plates for validation and secondary profiling or to normalize compound stock concentrations.</p> <a class="btn" href="https://www.sptlabtech.com/products/mosquito/mosquito-x1"> Explore mosquito X1 </a> </div> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=350&height=490&name=mosquito_X1-1.png" alt="mosquito_X1-1" loading="lazy" width="350" height="490" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=175&height=245&name=mosquito_X1-1.png 175w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=350&height=490&name=mosquito_X1-1.png 350w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=525&height=735&name=mosquito_X1-1.png 525w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=700&height=980&name=mosquito_X1-1.png 700w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=875&height=1225&name=mosquito_X1-1.png 875w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/01%20-%20Low%20Volume%20Liquid%20Handling/mosquito_X1-1.png?width=1050&height=1470&name=mosquito_X1-1.png 1050w" sizes="(max-width: 350px) 100vw, 350px"> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span id="hs_cos_wrapper_main_area-module-7" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"></span> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430274090" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <hr></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-16 main_area-row-6-padding dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430222740" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708430222740_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2 style="font-size: 20px; text-align: center; line-height: 1; font-weight: normal;">Looking to explore some of the automation solutions we offer?</h2> <h2 style="font-size: 24px; text-align: center; line-height: 1;">Then be sure to get in touch with one of our experts!</h2></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430383635" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="button"> <button> <a href="https://www.sptlabtech.com/contact"> Get In Touch </a> </button> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-19 dnd-section main_area-row-7-max-width-section-centering main_area-row-7-padding"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-20 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1725454294282" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1725454294282_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h5><strong>References</strong></h5> <ol> <li>Buitrago Santanilla A, Regalado EL, Pereira T, et al. Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Science. 2015; 347 (6217): 49-53. <a href="https://doi.org/10.1126/science.1259203">https://doi.org/10.1126/science.1259203</a></li> <li>Lin S, Dikler S, Blincoe WD, et al. Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS. Science. 2018; 361 (6402): eaar6236. <a href="https://doi.org/10.1126/science.aar6236">https://doi.org/10.1126/science.aar6236</a></li> <li>Pomberger, A, Pedrina McCarthy, A. A, Khan, A, et al. The Effect of Chemical Representation on Active Machine Learning Towards Closed-Loop Optimization. React. Chem. Eng. 2022, 7, 1368, <a href="https://doi.org/10.1039/D2RE00008C">https://doi.org/10.1039/D2RE00008C</a></li> <li>Gesmundo, N., Dykstra, K., Douthwaite, J.L. et al. Miniaturization of popular reactions from the medicinal chemists’ toolbox for ultrahigh-throughput experimentation. Nat. Synth 2. 2023, 1082–1091. <a href="https://doi.org/10.1038/s44160-023-00351-1">https://doi.org/10.1038/s44160-023-00351-1</a></li> <li>Taylor CJ, Pomberger A, Felton KC, et al. A Brief Introduction to Chemical Reaction Optimization. <em>Chem Rev</em>. 2023; 123 (6): 3089-3126. <a href="https://doi.org/10.1021/acs.chemrev.2c00798">https://doi.org/10.1021/acs.chemrev.2c00798</a></li> <li>Mahjour B, Zhang R, Shen Y, et al. Rapid planning and analysis of high-throughput experiment arrays for reaction discovery. Nat Commun. 2023; 14 (1): 3924. <a href="https://doi.org/10.1038/s41467-023-39531-0">https://doi.org/10.1038/s41467-023-39531-0</a></li> <li>Stevens R, Bendito-Moll E, Battersby DJ, et al. Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs. J Med Chem. 2023;66(22):15437-15452. <a href="https://doi.org/10.1021/acs.jmedchem.3c01604">https://doi.org/10.1021/acs.jmedchem.3c01604</a></li> </ol></span></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div data-global-resource-path="SPT-Labtech-2021/SPT-Labtech-Theme-2021/templates/partials/footer.html"><footer class="footer"> <div class="container"> <div class="container-fluid footer-inr"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1727255406258" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><footer class="footer"> <div class="footer-top"> <img src="https://www.sptlabtech.com/hubfs/Admin/Logos/SPT%20Labtech%20Logo.png" alt="Logo" class="footer-logo"> </div> <div class="footer-line"></div> <div class="footer-nav"> <a href="https://www.sptlabtech.com/products">Products</a> <a href="https://www.sptlabtech.com/company">Company</a> <a href="https://www.sptlabtech.com/culture">Culture</a> <a href="https://apply.workable.com/spt-labtech/">Careers</a> <a href="https://www.sptlabtech.com/resources">Resources</a> <a href="https://www.sptlabtech.com/product-inquiry">Contact</a> <a href="https://store.sptlabtech.com/">Shop</a> </div> <div class="footer-line"></div> <div class="footer-bottom"> <div class="column column-left"> <p style="font-size: 20px;"><strong>Subscribe to get our latest update</strong></p> <button class="subscribe-button" id="subscribeButton">Subscribe</button> </div> <div class="column column-right"> <p style="font-size: 20px;"> <strong>Follow Us</strong></p> <div class="social-icons"> <a href="https://www.linkedin.com" target="_blank"> <img src="https://www.sptlabtech.com/hubfs/Quantifoil%20Website/Admin%20only/Logos/Teal%20LinkedIn%20Logo%20Icon%20PNG.png.png" alt="LinkedIn"> </a> <a href="https://www.twitter.com" target="_blank"> <img src="https://www.sptlabtech.com/hubfs/Twitter%20-%20X%20New%20logo.png" alt="X"> </a> </div> </div> </div> <div class="footer-final"> <div> <a href="https://www.sptlabtech.com/privacy">Privacy Policy</a> <a href="https://www.sptlabtech.com/legal">Legal</a> </div> <div class="footer-date"> <p>© 2024 SPT Labtech Ltd</p> </div> </div> </footer>  <div id="popupForm" class="popup"> <div class="popup-content"> <span class="close-btn" id="closePopup"></span>  <span id="hs_cos_wrapper_widget_1727255406258_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_form" style="" data-hs-cos-general-type="widget" data-hs-cos-type="form"><h3 id="hs_cos_wrapper_form_640765073_title" class="hs_cos_wrapper form-title" data-hs-cos-general-type="widget_field" data-hs-cos-type="text"></h3> <div id="hs_form_target_form_640765073"></div> </span> </div> </div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </footer></div>  <script defer src="/hs/hsstatic/content-cwv-embed/static-1.1293/embed.js"></script> <script src="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/template_assets/85829631861/1690760505242/SPT-Labtech-2021/SPT-Labtech-Theme-2021/js/compiled.min.js"></script> <script> var hsVars = hsVars || {}; hsVars['language'] = 'en'; </script> <script src="/hs/hsstatic/cos-i18n/static-1.53/bundles/project.js"></script> <script src="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-2712622/1732567125858/module_-2712622_Site_Search_Input.min.js"></script> <script src="https://cdn2.hubspot.net/hub/-1/hub_generated/module_assets/-2712624/1732567128319/module_-2712624_Site_Search_Results.min.js"></script> <script src="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/76127708830/1655117433638/module_76127708830_Parallax_Image.min.js"></script> <script src="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/49540076202/1643122452660/module_49540076202_product_card_module.min.js"></script> <script src="https://www.sptlabtech.com/hs-fs/hub/6586853/hub_generated/module_assets/178599170471/1727256233458/module_178599170471_NEW_Global_Footer.min.js"></script>  <script data-hs-allowed="true" src="/_hcms/forms/v2.js"></script> <script data-hs-allowed="true"> var options = { portalId: '6586853', formId: '5b4046a5-3ae9-41a7-983d-d70e4888a4ed', formInstanceId: '2549', pageId: '162901815155', region: 'na1', pageName: "Medicinal Chemistry | SPT Labtech", inlineMessage: "Thanks for submitting the form.", rawInlineMessage: "Thanks for submitting the form.", hsFormKey: "ba57c87bd8eb8b53acd397b39cc76dfa", css: '', target: '#hs_form_target_form_640765073', contentType: "standard-page", formsBaseUrl: '/_hcms/forms/', formData: { cssClass: 'hs-form stacked hs-custom-form' } }; options.getExtraMetaDataBeforeSubmit = function() { var metadata = {}; if (hbspt.targetedContentMetadata) { var count = hbspt.targetedContentMetadata.length; var targetedContentData = []; for (var i = 0; i < count; i++) { var tc = hbspt.targetedContentMetadata[i]; if ( tc.length !== 3) { continue; } targetedContentData.push({ definitionId: tc[0], criterionId: tc[1], smartTypeId: tc[2] }); } metadata["targetedContentMetadata"] = JSON.stringify(targetedContentData); } return metadata; }; hbspt.forms.create(options); </script>  <script type="text/javascript"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); _hsq.push(["setCanonicalUrl", "https:\/\/www.sptlabtech.com\/applications\/medicinal-chemistry"]); _hsq.push(["setPageId", "162901815155"]); _hsq.push(["setContentMetadata", { "contentPageId": 162901815155, "legacyPageId": "162901815155", "contentFolderId": null, "contentGroupId": null, "abTestId": null, "languageVariantId": 162901815155, "languageCode": "en", }]); </script> <script type="text/javascript" id="hs-script-loader" async defer src="/hs/scriptloader/6586853.js"></script>  <script type="text/javascript"> var hsVars = { render_id: "ef68528c-17c8-4090-aa20-98c11157281e", ticks: 1732614046442, page_id: 162901815155, content_group_id: 0, portal_id: 6586853, app_hs_base_url: "https://app.hubspot.com", cp_hs_base_url: "https://cp.hubspot.com", language: "en", analytics_page_type: "standard-page", scp_content_type: "", analytics_page_id: "162901815155", category_id: 1, folder_id: 0, is_hubspot_user: false } </script> <script defer src="/hs/hsstatic/HubspotToolsMenu/static-1.354/js/index.js"></script> <script>(function(d,u,ac){var s=d.createElement('script');s.type='text/javascript';s.src='https://a.omappapi.com/app/js/api.min.js';s.async=true;s.dataset.user=u;s.dataset.account=ac;d.getElementsByTagName('head')[0].appendChild(s);})(document,65183,73101);</script> </body></html>

CINXE.COM

Medicinal Chemistry | SPT Labtech