DNA-Encoded Library (DEL) Screening

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class="flex"> <div class="application-bnr-text medium"> <div class="text-block"> <h1 class="title-symbol">DNA-Encoded Library (DEL) Screening</h1> <div id="hs_cos_wrapper_widget_1629798268172_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="banner_content.description"><p>DNA-encoded library (DEL) screening has emerged as a transformative technique in drug discovery, revolutionizing the way researchers identify potential therapeutic compounds.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module widget_1625497891256-hidden" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span 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class="container bullet-list-points"> <div class="cta-download-block"> <div class="tab-content"> <div class="tab-pane in active"> <div class="product-detail-block"> <div class="product-img"> <img src="https://www.sptlabtech.com/hubfs/DNA%20encoded%20libraries.png" alt="DNA encoded libraries" loading="lazy" style="max-width: 100%; height: auto;"> </div> <div class="product-info"> <h2>Introduction to DEL screening</h2> <h2 id="singlecellingenomicsexplained" style="font-size: 48px;"></h2> <p>DNA-encoded library (DEL) screening has emerged as a transformative technique in drug discovery, revolutionizing the way researchers identify potential therapeutic compounds. The technique involves synthesizing vast libraries of small molecules, each tagged with a unique DNA sequence that acts as a molecular barcode. These libraries can then be screened against a target protein to identify promising drug candidates efficiently and cost-effectively.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430628119" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708430628119_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2><strong><span data-contrast="auto">Enhancing drug discovery with DEL screening</span></strong><span data-ccp-props="{}"> </span></h2> <p><span data-contrast="auto">High-throughput screening is a cornerstone of early-phase drug discovery, allowing the rapid identification of potential hit compounds. However, the costs associated with traditional chemical libraries can be as high as $1 billion USD, meaning this approach can quickly become expensive and resource intensive.</span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">DNA-encoded libraries (DELs) offer a powerful and cost-effective alternative to traditional high-throughput screening (HTS) methods. These consist of compounds linked to unique DNA barcodes, allowing for the simultaneous screening of vast compound libraries through affinity selection. In this process, compounds that bind to target molecules are enriched, and their DNA tags are sequenced for identification. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">This method allows millions of compounds to be tested in a single tube, vastly increasing the scale and efficiency of screening compared to traditional HTS, which typically involves individual compounds in 384 or 1536-well microplates. Furthermore, affinity selection workflows are highly amenable to automated liquid handling technologies to ensure their throughput, reliability and data quality.</span><span data-ccp-props="{}"> </span></p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708428856139" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="block"> <img src="https://www.sptlabtech.com/hubfs/DNA-Encoded%20Library.png" data-speed="-1.5" class="img-parallax"> </div></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710265006637" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1710265006637_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p> </p> <h2><strong><span data-contrast="auto">Understanding the DEL screening workflow</span></strong><span data-ccp-props="{}"> </span></h2> <p><span data-contrast="auto">A typical DEL screening workflow allows researchers to screen vast libraries of small molecules quickly and efficiently.</span><span data-ccp-props="{}"> </span><span data-ccp-props="{}"></span></p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget widget_1729173146316-flexbox-positioning dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1729173146316" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1729173146316_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_linked_image" style="" data-hs-cos-general-type="widget" data-hs-cos-type="linked_image"><img src="https://www.sptlabtech.com/hubfs/DEL%20Screening%20Workflow.png" class="hs-image-widget " style="max-width: 100%; height: auto;" alt="DEL Screening Workflow" title="DEL Screening Workflow" loading="lazy"></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1729173132256" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1729173132256_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><ul> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">A diverse library of small molecules is synthesized through combinatorial chemistry, with each step including the addition of a DNA sequence that builds a unique barcode identifier.</span><span data-ccp-props="{}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">The encoded libraries are incubated with the target protein. Non-binding ligands are removed through washing, ensuring that only specific binders remain.</span><span data-ccp-props="{}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Bound molecules are eluted, and their DNA is amplified. Sequencing then identifies the hits from the screening.</span><span data-ccp-props="{}"> </span></li> </ul> <p><span data-contrast="auto">The remaining steps then follow the typical drug discovery pathway. Hits are synthesized and validated independently to confirm their binding affinity and biological activity. The most promising candidates undergo optimization to enhance potency, selectivity, and pharmacokinetic properties, followed by preclinical and clinical testing.</span><span data-ccp-props="{}"> </span></p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1729173176685" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1729173176685_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2> </h2> <h2><strong><span data-contrast="auto">The role of automation in DEL screening</span></strong><span data-ccp-props="{}"> </span></h2> <p><span data-contrast="auto">Multiple steps the workflow involve manual pipetting steps and are therefore prime candidates for automated liquid handling:</span><span data-ccp-props="{}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="1" data-aria-level="1"><strong><span data-contrast="auto">Increased throughput</span></strong><span data-contrast="auto">: Automation enables the parallel synthesis of vast chemical libraries, significantly boosting throughput while reducing manual errors.</span><span data-ccp-props="{}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1"><strong><span data-contrast="auto">Streamlined screening</span></strong><span data-contrast="auto">: Automated systems can manage incubation, washing, and elution steps with precision, ensuring high-throughput and consistent data quality.</span><span data-ccp-props="{}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="3" data-aria-level="1"><strong><span data-contrast="auto">Enhanced NGS preparation</span></strong><span data-contrast="auto">: Automating PCR setup and DNA preparation for NGS sequencing allows for the accurate handling of small volumes, increasing speed and accuracy beyond what is possible manually.</span><span data-ccp-props="{}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="6" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" aria-setsize="-1" data-aria-posinset="4" data-aria-level="1"><strong><span data-contrast="auto">Accelerated validation</span></strong><span data-contrast="auto">: Automation also speeds up downstream validation assays, making the overall process more efficient.</span><span data-ccp-props="{}"> </span></li> </ul> <p><span data-contrast="auto">For drug discovery labs, incorporating automation into DEL screening workflows means faster identification of promising candidates, more reliable results, and the ability to handle larger and more complex projects, ultimately accelerating the overall discovery process. </span><span data-ccp-props="{}"> </span></p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1628177031915" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="product-card-module anchor-point" id="product-card-module"> <div class="container bullet-list-points"> <div class="text-module bullet-list-points"> <h2></h2> </div> <div class="p-card-module-inr"> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>firefly<sup>®</sup></strong></h3> <p>Our all-in-one platform brings together multiple technologies within a single compact design, including non-contact dispensing, 96/384-well pipetting, shaking and temperature controlled incubation. Underpinned by powerful, intuitive software, firefly unlocks the potential of automation for all to accelerate genomics and drug discovery workflows.</p> <a class="btn" href="https://www.sptlabtech.com/products/firefly"> Explore firefly </a> </div> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=450&height=700&name=firefly-right.png" alt="firefly" loading="lazy" width="450" height="700" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=225&height=350&name=firefly-right.png 225w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=450&height=700&name=firefly-right.png 450w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=675&height=1050&name=firefly-right.png 675w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=900&height=1400&name=firefly-right.png 900w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=1125&height=1750&name=firefly-right.png 1125w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=1350&height=2100&name=firefly-right.png 1350w" sizes="(max-width: 450px) 100vw, 450px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=1200&height=1098&name=firefly%2B%20front%20facing%20half%20web.png" alt="firefly+ front facing half web" loading="lazy" width="1200" height="1098" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=600&height=549&name=firefly%2B%20front%20facing%20half%20web.png 600w, https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=1200&height=1098&name=firefly%2B%20front%20facing%20half%20web.png 1200w, https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=1800&height=1647&name=firefly%2B%20front%20facing%20half%20web.png 1800w, https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=2400&height=2196&name=firefly%2B%20front%20facing%20half%20web.png 2400w, https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=3000&height=2745&name=firefly%2B%20front%20facing%20half%20web.png 3000w, https://www.sptlabtech.com/hs-fs/hubfs/firefly%2B%20front%20facing%20half%20web.png?width=3600&height=3294&name=firefly%2B%20front%20facing%20half%20web.png 3600w" sizes="(max-width: 1200px) 100vw, 1200px"> </div> <div class="product-card-text pad-l75"> <h3>firefly+<sup>®</sup></h3> <p><span>firefly+ expands on the current liquid handling capabilities of firefly with an integrated thermocycler and additional labware capability, all while maintaining our commitment to usability and compact design. These additions facilitate longer hands-free workflows for increased .lab efficiency.</span></p> <a class="btn" href="https://www.sptlabtech.com/products/firefly/greater-walk-away-automation"> Explore firefly+ </a> </div> </div> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>mosquito<sup>®</sup></strong> HV genomics</h3> <p>mosquito ® HV genomics offers highly accurate and precise multi-channel pipetting from 500 nL to 5 µL allowing researchers to benefit from miniaturization across a range of applications, irrespective of liquid class. The instrument’s pre-sterilized disposable pipettes eliminate cross-contamination and maintain data integrity while the rapid plate-to-plate pipetting motion and tip exchange maximize speed and efficiency.</p> <a class="btn" href=""> Explore mosquito </a> </div> <div class="product-card-img"> <img src="https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=418&height=534&name=cp-img1.png" alt="" loading="lazy" width="418" height="534" srcset="https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=209&height=267&name=cp-img1.png 209w, https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=418&height=534&name=cp-img1.png 418w, https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=627&height=801&name=cp-img1.png 627w, https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=836&height=1068&name=cp-img1.png 836w, https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=1045&height=1335&name=cp-img1.png 1045w, https://19644453.fs1.hubspotusercontent-na1.net/hub/19644453/hubfs/cp-img1.png?width=1254&height=1602&name=cp-img1.png 1254w" sizes="(max-width: 418px) 100vw, 418px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=451&height=650&name=dragonfly-product-dfdiscovery---text-block-1.png" alt="dragonfly-product-dfdiscovery---text-block-1" loading="lazy" width="451" height="650" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=226&height=325&name=dragonfly-product-dfdiscovery---text-block-1.png 226w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=451&height=650&name=dragonfly-product-dfdiscovery---text-block-1.png 451w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=677&height=975&name=dragonfly-product-dfdiscovery---text-block-1.png 677w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=902&height=1300&name=dragonfly-product-dfdiscovery---text-block-1.png 902w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=1128&height=1625&name=dragonfly-product-dfdiscovery---text-block-1.png 1128w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=1353&height=1950&name=dragonfly-product-dfdiscovery---text-block-1.png 1353w" sizes="(max-width: 451px) 100vw, 451px"> </div> <div class="product-card-text pad-l75"> <h3><strong>dragonfly<sup>®</sup></strong> discovery</h3> <p>Multi-channel non-contact dispensing from positive displacement syringes. The dragonfly product range delivers accurate and repeatable nanoliter to milliliter dispensing, every time, irrespective of liquid viscosity or environmental conditions.</p> <a class="btn" href="//www-sptlabtech-com.sandbox.hs-sites.com/apricot-product-range-spt-labtech-0"> Explore dragonfly </a> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span id="hs_cos_wrapper_main_area-module-7" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"></span> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-section main_area-row-5-padding main_area-row-5-max-width-section-centering"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-16 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_17219139272393" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_17219139272393_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2>Conclusion</h2> <p>DNA-encoded library (DEL) screening is a powerful tool in the arsenal of drug discovery, offering unparalleled efficiency and accuracy in identifying potential therapeutic compounds. While the technique presents certain challenges, innovations in liquid handling solutions, such as SPT Labtech's firefly and firefly+, provide effective solutions that streamline workflows and enhance the overall efficiency of DEL screening. By leveraging these advanced technologies, researchers can unlock the full potential of DEL screening, accelerating the <a href="/applications/drug-discovery" rel="noopener">discovery of new drugs </a>and ultimately improving patient outcomes.</p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_1710348640448" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_1710348640448_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>Key Resources</h3></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-19 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710237004996" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <section class="vertical-tabs-section"> <div class="container"> <div class="how_work_flight"> <div class="vert-tab"> <div class="recr-content active" data-index="1"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">Poster ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>01.</h2> <h4>Accelerating Drug Discovery at Totus Medicines: DNA-Encoded Library Screening with firefly®</h4> <p></p><p><span>Totus Medicines has developed a platform capable of identifying covalent small molecule ligands via high-throughput cell-based DEL screening. This poster outlines how the team is streamlining hit identification, optimization, and technology development, to accelerate the discovery of novel therapeutic candidates using our firefly automated liquid handling platform. We present the metrics that have been collected over one year of screening using Totus Medicine’s proprietary covalent DELs to run over 2000 unique selections against a large number of targets, spanning diverse therapeutic areas.</span></p> <p style="text-align: center;"><a href="https://6586853.fs1.hubspotusercontent-na1.net/hubfs/6586853/SPT%20Labtech%20-%20Totus%20-%20SLAS2024%20poster.pdf" rel="noopener">Read More</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=200&height=110&name=DEL%20screening%20Totus.png" alt="DEL screening Totus" loading="lazy" width="200" height="110" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=100&height=55&name=DEL%20screening%20Totus.png 100w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=200&height=110&name=DEL%20screening%20Totus.png 200w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=300&height=165&name=DEL%20screening%20Totus.png 300w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=400&height=220&name=DEL%20screening%20Totus.png 400w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=500&height=275&name=DEL%20screening%20Totus.png 500w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20Totus.png?width=600&height=330&name=DEL%20screening%20Totus.png 600w" sizes="(max-width: 200px) 100vw, 200px"> </div> </div> </div> <div class="recr-content " data-index="2"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">Webinar ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>02.</h2> <h4>Accelerate small molecule lead discovery with automated multichannel pipetting and DEL technology</h4> <p></p><p><span>When </span><span>utilizing</span><span> screening methods such as DEL technology, follow-up hit validation must be performed using traditional biochemical assays.<br>In this webinar, the team from X-Chem reviews the use of mosquito LV to accelerate early-stage small molecule lead discovery through the lens of Hydroxyacid oxidase 1 (HAO1). <br></span></p> <p style="text-align: center;"><a href="/how-to-accelerate-small-molecule-lead-discovery-with-automated-multichannel-pipetting-and-del-technology-register" rel="noopener">Watch Now</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=190&height=100&name=DEL%20screening%20XChem%20webinar.png" alt="DEL screening XChem webinar" loading="lazy" width="190" height="100" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=95&height=50&name=DEL%20screening%20XChem%20webinar.png 95w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=190&height=100&name=DEL%20screening%20XChem%20webinar.png 190w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=285&height=150&name=DEL%20screening%20XChem%20webinar.png 285w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=380&height=200&name=DEL%20screening%20XChem%20webinar.png 380w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=475&height=250&name=DEL%20screening%20XChem%20webinar.png 475w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem%20webinar.png?width=570&height=300&name=DEL%20screening%20XChem%20webinar.png 570w" sizes="(max-width: 190px) 100vw, 190px"> </div> </div> </div> <div class="recr-content " data-index="3"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">Application Note ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>03.</h2> <h4>mosquito® LV: An assay's best friend</h4> <p></p><p>After a successful DEL screen, it is essential to have access to a high-throughput method of assaying compounds to validate hits. Learn how mosquito LV's positive displacement nanoliter pipetting has improved the way that X-Chem work with off-DNA compounds synthesized from DELcore and DELflex collaborations.</p> <p style="text-align: center;"><a href="https://6586853.fs1.hubspotusercontent-na1.net/hubfs/6586853/XChem%20mosquito%20LV_An%20assays%20best%20friend_app%20note_FINAL.pdf" rel="noopener">Download now</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=100&height=156&name=DEL%20screening%20XChem.png" alt="DEL screening XChem" loading="lazy" width="100" height="156" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=50&height=78&name=DEL%20screening%20XChem.png 50w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=100&height=156&name=DEL%20screening%20XChem.png 100w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=150&height=234&name=DEL%20screening%20XChem.png 150w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=200&height=312&name=DEL%20screening%20XChem.png 200w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=250&height=390&name=DEL%20screening%20XChem.png 250w, https://www.sptlabtech.com/hs-fs/hubfs/DEL%20screening%20XChem.png?width=300&height=468&name=DEL%20screening%20XChem.png 300w" sizes="(max-width: 100px) 100vw, 100px"> </div> </div> </div> </div> </div> </div> </section> <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.6.1/jquery.min.js"></script> <script> $(document).ready(function() { $(".recr-content").click(function() { var index = $(this).data('index'); 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