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var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <div class="DesignSystem" style="margin-top:-40px"><div class="PageHeader"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><div class="u-floatLeft u-fs24 u-tcGrayDarkest"><span class="PageHeader-title u-m0x u-fw700 u-mr5x u-pr5x u-borderColorGrayLight u-borderRight1"><a href="https://azospvr.academia.edu/"><span class="u-linkUnstyled u-tcGrayDarkest">Azienda Ospedaliera Universitaria Integrata di Verona</span></a></span><h1 class="u-m0x u-fw300 u-fs24 u-displayInline">Chirurgia Plastica</h1></div><div class="u-floatRight u-mt1x"></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline"><li class="u-floatLeft u-pr5x u-mr5x u-borderColorGrayLight u-borderRight1"><a href="https://azospvr.academia.edu/"><span><i class="fa fa-arrow-left"></i>  All Departments</span></a></li><li class="u-floatLeft active"><a href="https://azospvr.academia.edu/Departments/Chirurgia_Plastica/Documents">14 Papers</a></li><li class="u-floatLeft"><a href="https://azospvr.academia.edu/Departments/Chirurgia_Plastica">1 Researchers</a></li></ul></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="u-ph0x"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47348814" data-work_id="47348814" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47348814/Pathophysiology_Study_of_Filler_Induced_Blindness">Pathophysiology Study of Filler-Induced Blindness</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A number of authors have proposed retrograde arterial embolism as the responsible mechanism for filler-induced blindness. However, no previous human study has substantiated this proposed mechanism. The aim of this study was to investigate... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47348814" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A number of authors have proposed retrograde arterial embolism as the responsible mechanism for filler-induced blindness. However, no previous human study has substantiated this proposed mechanism. The aim of this study was to investigate the pathophysiology of filler-induced blindness using a fresh cadaver perfusion technique. A fresh cadaver head perfusion model that simulates both physiologic blood pressure and flow rate of the carotid artery, ophthalmic artery, supratrochlear artery was used. The common carotid artery was cannulated and the internal jugular vein exposed for open venous drainage. A plasma-based perfusate was circulated through the cadaver head which was connected to a perfusion system consisting of a roller pump, preload reservoir, and pressure monitor. The hyaluronic acid filler mixed with methylene blue was injected into the cannulated superficial branch of the supratrochlear artery. Cadaver dissection, angiographic study, and histology were used to investigate...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47348814" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b2ac47dee61c1dd226a1e0cd2eb6b17b" rel="nofollow" data-download="{"attachment_id":66487778,"asset_id":47348814,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66487778/download_file?st=MTczMjQyMjIyOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_47348814 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47348814"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47348814, container: ".js-paper-rank-work_47348814", }); 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href="https://www.academia.edu/47348892/Patient_Satisfaction_With_an_Early_Smartphone_Based_Cosmetic_Surgery_Postoperative_Follow_Up">Patient Satisfaction With an Early Smartphone-Based Cosmetic Surgery Postoperative Follow-Up</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47348892" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a5da44dee95cdf9fb5d051264e1860b8" rel="nofollow" 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47348893" data-work_id="47348893" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47348893/Pathophysiology_Study_of_Filler_Induced_Blindness">Pathophysiology Study of Filler-Induced Blindness</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A number of authors have proposed retrograde arterial embolism as the responsible mechanism for filler-induced blindness. However, no previous human study has substantiated this proposed mechanism. The aim of this study was to investigate... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47348893" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A number of authors have proposed retrograde arterial embolism as the responsible mechanism for filler-induced blindness. However, no previous human study has substantiated this proposed mechanism. The aim of this study was to investigate the pathophysiology of filler-induced blindness using a fresh cadaver perfusion technique. A fresh cadaver head perfusion model that simulates both physiologic blood pressure and flow rate of the carotid artery, ophthalmic artery, supratrochlear artery was used. The common carotid artery was cannulated and the internal jugular vein exposed for open venous drainage. A plasma-based perfusate was circulated through the cadaver head which was connected to a perfusion system consisting of a roller pump, preload reservoir, and pressure monitor. The hyaluronic acid filler mixed with methylene blue was injected into the cannulated superficial branch of the supratrochlear artery. 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However, no previous human study has substantiated this proposed mechanism. The aim of this study was to investigate the pathophysiology of filler-induced blindness using a fresh cadaver perfusion technique. A fresh cadaver head perfusion model that simulates both physiologic blood pressure and flow rate of the carotid artery, ophthalmic artery, supratrochlear artery was used. The common carotid artery was cannulated and the internal jugular vein exposed for open venous drainage. A plasma-based perfusate was circulated through the cadaver head which was connected to a perfusion system consisting of a roller pump, preload reservoir, and pressure monitor. The hyaluronic acid filler mixed with methylene blue was injected into the cannulated superficial branch of the supratrochlear artery. 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$(".js-view-count-work_47348901").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78297659" data-work_id="78297659" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78297659/Abstract_Extended_Normothermic_Ex_Situ_Limb_Perfusion_Preserves_Limbs_Viable_and_Functional_Up_to_44_Hours">Abstract: Extended Normothermic Ex-Situ Limb Perfusion Preserves Limbs Viable and Functional Up to 44 Hours</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">M oday, O cber 9, 2017 is hindered in part by the availability of limbs which can survive a limited amount of time disconnected from the body. Cryobiology is the scientific field which investigates biology at low temperatures.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78297659" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">M oday, O cber 9, 2017 is hindered in part by the availability of limbs which can survive a limited amount of time disconnected from the body. Cryobiology is the scientific field which investigates biology at low temperatures. Cryobiologists have long sought to cryopreserve biological samples ranging from single cells to complex organs and whole animals. Vitrification is the transformation of a substance into a non-crystalline amorphous solid using rapid heat removal. Directional freezing is a technique, consisting of highly controlled and cell-friendly ice crystal morphology that significantly reduces mechanical damage. Extremely efficient heat removal and controlled ice crystal propagation make it suitable for freezing both small and large volumes alike. Combining Directional freezing and VCA may open the door for “Organ Banking”. If composite tissue could be frozen and then thawed without damage, non transplanted tissue and organ waste would be reduced, potentially enabling bette...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78297659" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="cce46db2dc16ae47a3b422aa367cf866" rel="nofollow" data-download="{"attachment_id":85394037,"asset_id":78297659,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85394037/download_file?st=MTczMjQyMjIyOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78297659 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78297659"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78297659, container: ".js-paper-rank-work_78297659", }); });</script></li><li class="js-percentile-work_78297659 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78297659; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78297659"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78297659 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78297659"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78297659; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78297659]").text(description); $(".js-view-count-work_78297659").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78297659").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78297661" data-work_id="78297661" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78297661/Abstract_Hand_Transplantation_in_Patients_with_Extensive_Burns_of_the_Upper_Extremities_Anatomical_Study_on_Feasibility">Abstract: Hand Transplantation in Patients with Extensive Burns of the Upper Extremities: Anatomical Study on Feasibility</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">RESULTS AND CONCLUSION: The challenge of craniopagus separation is due to the complexity of the venous plexus and shared dural venous sinus. Therefore, separation of the venous system of the twins requires meticulous planning and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78297661" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">RESULTS AND CONCLUSION: The challenge of craniopagus separation is due to the complexity of the venous plexus and shared dural venous sinus. Therefore, separation of the venous system of the twins requires meticulous planning and stereoscopic appreciation of the vasculature. Both VSP and 3D printed models were critical as references of the venous anatomy during separation and to the survival of both twins. VSP and 3D printing were also employed successfully in predicting the scalp and skull defects and designing custom guides and jigs which were used intraoperatively and facilitated surgical reconstruction.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78297661" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d7580fb9f3796fc79e86ad86a00d9ed2" rel="nofollow" data-download="{"attachment_id":85394040,"asset_id":78297661,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85394040/download_file?st=MTczMjQyMjIyOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78297661 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78297661"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78297661, container: ".js-paper-rank-work_78297661", }); });</script></li><li class="js-percentile-work_78297661 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78297661; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78297661"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78297661 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78297661"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78297661; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78297661]").text(description); $(".js-view-count-work_78297661").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78297661").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78297663" data-work_id="78297663" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78297663/Abstract_Extended_Propeller_Gluteal_Thigh_Flap_to_Reconstruct_Perineal_Defects_Following_Abdominoperineal_Resection">Abstract: Extended Propeller Gluteal Thigh Flap to Reconstruct Perineal Defects Following Abdominoperineal Resection</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Suday, Sptem er 0, 2018 and fasciocutaneous flaps. This study assesses the effectiveness of the SMART course in improving participant competency. Methods: Sixty-four orthopaedic surgeons from Nepal and Bhutan participated in the Nepal... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78297663" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Suday, Sptem er 0, 2018 and fasciocutaneous flaps. This study assesses the effectiveness of the SMART course in improving participant competency. Methods: Sixty-four orthopaedic surgeons from Nepal and Bhutan participated in the Nepal SMART course in 2016 and 2017. Demographic information was collected through a pre-course survey. A competency test with plastic and orthopaedic surgery questions from prior US in-training plastic surgery exams was administered to attendees immediately before and after the course. Data were analyzed for statistically significant differences before and after the course.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78297663" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4c04efe7d2fa77bbb97f3511ec714a59" rel="nofollow" data-download="{"attachment_id":85394042,"asset_id":78297663,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85394042/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78297663 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78297663"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78297663, container: ".js-paper-rank-work_78297663", }); });</script></li><li class="js-percentile-work_78297663 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78297663; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78297663"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78297663 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78297663"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78297663; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78297663]").text(description); $(".js-view-count-work_78297663").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78297663").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78297663"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78297663]'), work: {"id":78297663,"title":"Abstract: Extended Propeller Gluteal Thigh Flap to Reconstruct Perineal Defects Following Abdominoperineal Resection","created_at":"2022-05-03T00:47:25.865-07:00","owner_id":52849455,"url":"https://www.academia.edu/78297663/Abstract_Extended_Propeller_Gluteal_Thigh_Flap_to_Reconstruct_Perineal_Defects_Following_Abdominoperineal_Resection","slug":"Abstract_Extended_Propeller_Gluteal_Thigh_Flap_to_Reconstruct_Perineal_Defects_Following_Abdominoperineal_Resection","dom_id":"work_78297663","summary":"Suday, Sptem er 0, 2018 and fasciocutaneous flaps. This study assesses the effectiveness of the SMART course in improving participant competency. Methods: Sixty-four orthopaedic surgeons from Nepal and Bhutan participated in the Nepal SMART course in 2016 and 2017. Demographic information was collected through a pre-course survey. A competency test with plastic and orthopaedic surgery questions from prior US in-training plastic surgery exams was administered to attendees immediately before and after the course. Data were analyzed for statistically significant differences before and after the course.","publication":"Plastic and Reconstructive Surgery Global Open","publication_with_fallback":"Plastic and Reconstructive Surgery Global Open","downloadable_attachments":[{"id":85394042,"asset_id":78297663,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/85394042/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/85394042/gox-6-077.PMC6212202-libre.pdf?1651564217=\u0026response-content-disposition=attachment%3B+filename%3DAbstract_Extended_Propeller_Gluteal_Thig.pdf\u0026Expires=1732425829\u0026Signature=LyduzhcgcziyJIwuwyY247ByOsSegEcAxNQA62noLxKNGckCjW9Al8pJesFJeVBt9MaZpiMTd43lQWmVP4u3wvG6toFS-lpeANNAtorQ-h0JfoahFeqRiyHktqJadFAnoNW5npnUn~jH4cjDKU5--ztnVb6RFXUHYS3EopYVHlvyOsYGbDoDysXONHAn9t1k6PEKu2dFMEOkdY2Rm6VzYV-5g8HofjiUAytU7~L-T8kJLpbtTLTH5d3206xd8B3JZC~NxcJOY6UIvYLRabjazVlJz1b0PiPRxohtEqlvXgp7W~X8Q~DqUPoBLRKgyxWJx5A0jVJe9LoAl73xXwLSYQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/85394042/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/85394042/mini_magick20220503-28805-es3y6a.png?1651564077"}],"downloadable_attachments_with_full_thumbnails":[{"id":85394042,"asset_id":78297663,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/85394042/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/85394042/gox-6-077.PMC6212202-libre.pdf?1651564217=\u0026response-content-disposition=attachment%3B+filename%3DAbstract_Extended_Propeller_Gluteal_Thig.pdf\u0026Expires=1732425830\u0026Signature=L8ueeUJ9~meVgOX3-KB85KEt43AX5~YftaKJS5TUiRiemoS7QJXjf0HU7~mQs~~uo6hY5EZnxBe3vWd8zfEbfiAJJVEHqjm9rqur~JsenTsxFGxvEti232d-jFvVekzUKmewHcd8c6TNquCqzhje2dk~SbHVplNwi2xjXsEMesahYuwhOKMl68iI9f18S1FUxRRxFz4S3V4KVjIAK2sPnHqQS9CZJzxSFVAwxQwhIub6F-s4uOBahxpvZGtVYZBD8jVjZLEKF3VnnqjlaRq7Kx3NJdRygn5aFj6vSeGv7rBHYcOrc6NBOxfz0SE5BYxacraDTMNSD2M96xDKH0qdzA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/85394042/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/85394042/mini_magick20220503-28805-es3y6a.png?1651564077"}],"has_pdf":true,"has_fulltext":true,"page_count":2,"ordered_authors":[{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}],"publication_year":2018,"publication_year_with_fallback":2018,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_78297665" data-work_id="78297665" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/78297665/Abstract_Full_Facial_Allotransplantation_Including_the_Temporomandibular_Joints_An_Anatomical_Study_and_Surgical_Protocol">Abstract: Full Facial Allotransplantation Including the Temporomandibular Joints: An Anatomical Study and Surgical Protocol</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">INTRODUCTION: Face allotransplantation cardinally shifted the reconstruction paradigm of unmanageable facial defects. Incorporation of temporomandibular joint (TMJ) in total face allotransplant can further improve functional outcome in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78297665" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">INTRODUCTION: Face allotransplantation cardinally shifted the reconstruction paradigm of unmanageable facial defects. Incorporation of temporomandibular joint (TMJ) in total face allotransplant can further improve functional outcome in these patients. The purpose of our study was to evaluate the vascular supply of TMJ and develop a surgical protocol of a total face allotransplantation including TMJ.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78297665" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a3f64338e8960056e9ce13568c323522" rel="nofollow" data-download="{"attachment_id":85394044,"asset_id":78297665,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85394044/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78297665 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78297665"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78297665, container: ".js-paper-rank-work_78297665", }); 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We incidentally discovered a previously unrecognized pathologic entity – primary asymptomatic lymphatic insufficiency – which... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_78297667" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">CONCLUSION: This study demonstrated the effectiveness of ICG lymphography in diagnosing primary lymphedema. We incidentally discovered a previously unrecognized pathologic entity – primary asymptomatic lymphatic insufficiency – which potentially explains the inconsistent pathogenesis of lymphedema following oncologic interventions, as these patients may be more likely to develop lymphedema compared to their healthy counterparts due to pre-existing disease. This pathologic entity also raises caution over performing lymphatic tissue transfer in patients with primary disease, as transfer surgery may be the last straw necessary to cause lymphedema in the donor region. Further investigation is warranted.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/78297667" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bbc6c79549322fd203dfbe27021ad863" rel="nofollow" data-download="{"attachment_id":85394045,"asset_id":78297667,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85394045/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_78297667 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="78297667"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 78297667, container: ".js-paper-rank-work_78297667", }); });</script></li><li class="js-percentile-work_78297667 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78297667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_78297667"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_78297667 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="78297667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78297667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78297667]").text(description); $(".js-view-count-work_78297667").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_78297667").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="78297667"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=78297667]'), work: {"id":78297667,"title":"Abstract: Normothermic Ex-Situ Perfusion of Human Upper Extremity","created_at":"2022-05-03T00:47:26.212-07:00","owner_id":52849455,"url":"https://www.academia.edu/78297667/Abstract_Normothermic_Ex_Situ_Perfusion_of_Human_Upper_Extremity","slug":"Abstract_Normothermic_Ex_Situ_Perfusion_of_Human_Upper_Extremity","dom_id":"work_78297667","summary":"CONCLUSION: This study demonstrated the effectiveness of ICG lymphography in diagnosing primary lymphedema. 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class="u-positionAbsolute" data-has-card-for-ri-list="92805011"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="438969" href="https://www.academia.edu/Documents/in/Allotransplantation">Allotransplantation</a><script data-card-contents-for-ri="438969" type="text/json">{"id":438969,"name":"Allotransplantation","url":"https://www.academia.edu/Documents/in/Allotransplantation","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=92805011]'), work: {"id":92805011,"title":"Abstract: Full Facial Allotransplantation Including the Temporomandibular Joints: An Anatomical Study and Surgical Protocol","created_at":"2022-12-13T09:26:08.607-08:00","owner_id":52849455,"url":"https://www.academia.edu/92805011/Abstract_Full_Facial_Allotransplantation_Including_the_Temporomandibular_Joints_An_Anatomical_Study_and_Surgical_Protocol","slug":"Abstract_Full_Facial_Allotransplantation_Including_the_Temporomandibular_Joints_An_Anatomical_Study_and_Surgical_Protocol","dom_id":"work_92805011","summary":null,"publication":"Plastic and reconstructive surgery. 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Particularly, ethosomes based on phosphatidylcholine 0.9% w/w and transethosomes based on phosphatidylcholine 0.9 or 2.7% w/w plus polysorbate 80 0.3% w/w as... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_92805027" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In this study, the transdermal fate of vesicular nanosystems was investigated. Particularly, ethosomes based on phosphatidylcholine 0.9% w/w and transethosomes based on phosphatidylcholine 0.9 or 2.7% w/w plus polysorbate 80 0.3% w/w as an edge activator were prepared and characterized. The vesicle mean size, morphology and deformability were influenced by both phosphatidylcholine and polysorbate 80. Indeed, the mean diameters of ethosome were around 200 nm, while transethosome’s mean diameters were 146 or 350 nm in the case of phosphatidylcholine 0.9 or 2.7%, w/w, respectively. The highest deformability was achieved by transethosomes based on phosphatidylcholine 0.9%, w/w. The three types of vesicular nanosystems were applied on explanted human skin maintained in a bioreactor. Transmission electron microscopy demonstrated that all vesicles were able to enter the skin, keeping their structural integrity. Notably, the vesicle penetration capability was influenced by their physical-ch...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/92805027" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2b85c1c23fe049c161a02bd2caa43927" rel="nofollow" data-download="{"attachment_id":95716651,"asset_id":92805027,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/95716651/download_file?st=MTczMjQyMjIzMCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_92805027 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="92805027"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 92805027, container: ".js-paper-rank-work_92805027", }); 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$(".js-view-count[data-work-id=92805027]").text(description); $(".js-view-count-work_92805027").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_92805027").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="92805027"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="276821" href="https://www.academia.edu/Documents/in/Molecular_sciences">Molecular sciences</a><script data-card-contents-for-ri="276821" type="text/json">{"id":276821,"name":"Molecular sciences","url":"https://www.academia.edu/Documents/in/Molecular_sciences","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=92805027]'), work: {"id":92805027,"title":"Ex Vivo Evaluation of Ethosomes and Transethosomes Applied on Human Skin: A Comparative Study","created_at":"2022-12-13T09:26:21.779-08:00","owner_id":52849455,"url":"https://www.academia.edu/92805027/Ex_Vivo_Evaluation_of_Ethosomes_and_Transethosomes_Applied_on_Human_Skin_A_Comparative_Study","slug":"Ex_Vivo_Evaluation_of_Ethosomes_and_Transethosomes_Applied_on_Human_Skin_A_Comparative_Study","dom_id":"work_92805027","summary":"In this study, the transdermal fate of vesicular nanosystems was investigated. Particularly, ethosomes based on phosphatidylcholine 0.9% w/w and transethosomes based on phosphatidylcholine 0.9 or 2.7% w/w plus polysorbate 80 0.3% w/w as an edge activator were prepared and characterized. The vesicle mean size, morphology and deformability were influenced by both phosphatidylcholine and polysorbate 80. Indeed, the mean diameters of ethosome were around 200 nm, while transethosome’s mean diameters were 146 or 350 nm in the case of phosphatidylcholine 0.9 or 2.7%, w/w, respectively. The highest deformability was achieved by transethosomes based on phosphatidylcholine 0.9%, w/w. The three types of vesicular nanosystems were applied on explanted human skin maintained in a bioreactor. Transmission electron microscopy demonstrated that all vesicles were able to enter the skin, keeping their structural integrity. 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Therefore, developing highly reliable skin models is crucial for preclinical studies.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_99501652" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Skin is a major administration route for drugs, and all transdermal formulations must be tested for their capability to overcome the cutaneous barrier. Therefore, developing highly reliable skin models is crucial for preclinical studies. The current in vitro models are unable to replicate the living skin in all its complexity; thus, to date, excised human skin is considered the gold standard for in vitro permeation studies. However, skin explants have a limited life span. In an attempt to overcome this problem, we used an innovative bioreactor that allowed us to achieve good structural and functional preservation in vitro of explanted human skin for up to 72 h. This device was then used to set up an in vitro inflammatory model by applying two distinct agents mimicking either exogenous or endogenous stimuli: i.e., dithranol, inducing the contact dermatitis phenotype, and the substance P, mimicking neurogenic inflammation. Our in vitro system proved to reproduce inflammatory events ob...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/99501652" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1ac44d48c885e93504705e399d12117b" rel="nofollow" data-download="{"attachment_id":100573241,"asset_id":99501652,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/100573241/download_file?st=MTczMjQyMjIzMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_99501652 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="99501652"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 99501652, container: ".js-paper-rank-work_99501652", }); 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However, EVNLP cannot preserve the organ viability infinitely. We identified evidence of mitochondrial injury (swelling, elongation, and membrane disruption) after 24 hours of EVNLP of human upper extremities. The goal of this study was to identify metabolic derangements in the skeletal muscle during EVNLP.Materials and MethodsFourteen human upper extremities were procured from organ donors after family consent. Seven limbs underwent EVNLP for an average of 41.6 ± 9.4 hours, and seven contralateral limbs were preserved at 4°C for the same amount of time. Muscle biopsies were performed at 24 hours of perfus...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/111596060" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dd97443c92bbc6a286a8ebdfe7fef5ae" rel="nofollow" data-download="{"attachment_id":109088696,"asset_id":111596060,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/109088696/download_file?st=MTczMjQyMjIzMSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52849455" href="https://azospvr.academia.edu/EdoardoDallaPozza">Edoardo Dalla Pozza</a><script data-card-contents-for-user="52849455" type="text/json">{"id":52849455,"first_name":"Edoardo","last_name":"Dalla Pozza","domain_name":"azospvr","page_name":"EdoardoDallaPozza","display_name":"Edoardo Dalla Pozza","profile_url":"https://azospvr.academia.edu/EdoardoDallaPozza","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_111596060 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="111596060"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 111596060, container: ".js-paper-rank-work_111596060", }); 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However, EVNLP cannot preserve the organ viability infinitely. We identified evidence of mitochondrial injury (swelling, elongation, and membrane disruption) after 24 hours of EVNLP of human upper extremities. The goal of this study was to identify metabolic derangements in the skeletal muscle during EVNLP.Materials and MethodsFourteen human upper extremities were procured from organ donors after family consent. Seven limbs underwent EVNLP for an average of 41.6 ± 9.4 hours, and seven contralateral limbs were preserved at 4°C for the same amount of time. 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