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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Clazakizumab">Clazakizumab</span></caption><tbody><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">Monoclonal antibody</a></th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/File:Engineered_monoclonal_antibodies.svg" title="File:Engineered monoclonal antibodies.svg">Type</a></th><td class="infobox-data">Whole antibody</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Monoclonal_antibody#Production" title="Monoclonal antibody">Source</a></th><td class="infobox-data"><a href="/wiki/Humanized" class="mw-redirect" title="Humanized">Humanized</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Antigen" title="Antigen">Target</a></th><td class="infobox-data"><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">ALD518, BMS-945429</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data">infusion</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li>none</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li>investigational</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=1236278-28-6">1236278-28-6</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li>none</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/4S38Z8RA9O">4S38Z8RA9O</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D10312">D10312</a></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>6426</sub><span title="Hydrogen">H</span><sub>9972</sub><span title="Nitrogen">N</span><sub>1724</sub><span title="Oxygen">O</span><sub>2032</sub><span title="Sulfur">S</span><sub>42</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7005145239020000000♠"></span>145<span style="margin-left:.25em;">239</span>.02</span> g·mol<sup>−1</sup></td></tr></tbody></table> <p><b>Clazakizumab</b> (formerly <b>ALD518</b> and <b>BMS-945429</b>), an <a href="/wiki/Investigational_drug" class="mw-redirect" title="Investigational drug">investigational drug</a>, is an <a href="/wiki/Aglycosylated" class="mw-redirect" title="Aglycosylated">aglycosylated</a>, humanized rabbit <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibody</a> against <a href="/wiki/Interleukin-6" class="mw-redirect" title="Interleukin-6">interleukin-6</a>.<sup id="cite_ref-Handbook_1-0" class="reference"><a href="#cite_note-Handbook-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Clazakizumab was developed by <a href="/wiki/Bristol_Myers_Squib" class="mw-redirect" title="Bristol Myers Squib">Bristol Myers Squib</a> and <a href="/wiki/Alder_Biopharmaceuticals" class="mw-redirect" title="Alder Biopharmaceuticals">Alder Biopharmaceuticals</a>. A preliminary randomized, double-blind, <a href="/wiki/Placebo" title="Placebo">placebo</a>-controlled, <a href="/wiki/Phase_2_clinical_trial" class="mw-redirect" title="Phase 2 clinical trial">phase 2</a> dose-ranging study of clazakizumab in <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a> patients, funded by the manufacturer, suggested that clazakizumab may be an effective treatment option for musculoskeletal aspects of <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>; however, the antibody lacked a <a href="/wiki/Dose-response_effect" class="mw-redirect" title="Dose-response effect">dose-response effect</a>.<sup id="cite_ref-ArthRheum1_2-0" class="reference"><a href="#cite_note-ArthRheum1-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clazakizumab&action=edit&section=1" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a> (Actemra) an anti-IL-6 receptor mAb</li> <li><a href="/wiki/Anti-IL-6" class="mw-redirect" title="Anti-IL-6">Anti-IL-6</a>, other anti-interleukin-6 agents</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clazakizumab&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist 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.cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=svHsBQAAQBAJ&q=Clazakizumab,+BMS-945429+ALD518&pg=PA987"><i>Handbook of Therapeutic Antibodies, Volume 2</i></a>. Wiley Blackwell. 2007. p. 987. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783527329373" title="Special:BookSources/9783527329373"><bdi>9783527329373</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">January 23,</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Handbook+of+Therapeutic+Antibodies%2C+Volume+2&rft.pages=987&rft.pub=Wiley+Blackwell&rft.date=2007&rft.isbn=9783527329373&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DsvHsBQAAQBAJ%26q%3DClazakizumab%2C%2BBMS-945429%2BALD518%26pg%3DPA987&rfr_id=info%3Asid%2Fen.wikipedia.org%3AClazakizumab" class="Z3988"></span></span> </li> <li id="cite_note-ArthRheum1-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-ArthRheum1_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMeaseGottlieb2016" class="citation journal cs1">Mease PJ, Gottlieb AB, et al. (September 2016). "The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis". <i>Arthritis Rheumatol</i>. <b>68</b> (9): <span class="nowrap">2163–</span>73. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fart.39700">10.1002/art.39700</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27059799">27059799</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:3644962">3644962</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arthritis+Rheumatol&rft.atitle=The+efficacy+and+safety+of+clazakizumab%2C+an+anti-interleukin-6+monoclonal+antibody%2C+in+a+phase+IIb+study+of+adults+with+active+psoriatic+arthritis.&rft.volume=68&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2163-%3C%2Fspan%3E73&rft.date=2016-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A3644962%23id-name%3DS2CID&rft_id=info%3Apmid%2F27059799&rft_id=info%3Adoi%2F10.1002%2Fart.39700&rft.aulast=Mease&rft.aufirst=PJ&rft.au=Gottlieb%2C+AB&rfr_id=info%3Asid%2Fen.wikipedia.org%3AClazakizumab" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monoclonals_for_immune_system" title="Template:Monoclonals for immune system"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monoclonals_for_immune_system" title="Template talk:Monoclonals for immune system"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monoclonals_for_immune_system" title="Special:EditPage/Template:Monoclonals for immune system"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Monoclonal_antibodies_for_the_immune_system431" style="font-size:114%;margin:0 4em"><a href="/wiki/Monoclonal_antibodies" class="mw-redirect" title="Monoclonal antibodies">Monoclonal antibodies</a> for the <a href="/wiki/Immune_system" title="Immune system">immune system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%"><a href="/wiki/Immune_system" title="Immune system">Immune system</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Human</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Immunosuppression" title="Immunosuppression">Immunosuppression</a></i>: <a href="/wiki/Abrilumab" title="Abrilumab">Abrilumab</a></li> <li><a href="/wiki/Adalimumab" title="Adalimumab">Adalimumab</a><sup>#</sup></li> <li><a href="/wiki/Anifrolumab" title="Anifrolumab">Anifrolumab</a></li> <li><a href="/wiki/Atorolimumab" title="Atorolimumab">Atorolimumab</a></li> <li><a href="/wiki/Avelumab" title="Avelumab">Avelumab</a></li> <li><a href="/w/index.php?title=Avdoralimab&action=edit&redlink=1" class="new" title="Avdoralimab (page does not exist)">Avdoralimab</a></li> <li><a href="/wiki/Belimumab" title="Belimumab">Belimumab</a></li> <li><a href="/wiki/Bleselumab" title="Bleselumab">Bleselumab</a></li> <li><a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Camidanlumab_tesirine" title="Camidanlumab tesirine">Camidanlumab tesirine</a></li> <li><a href="/wiki/Carlumab" title="Carlumab">Carlumab</a></li> <li><a href="/wiki/Cemiplimab" title="Cemiplimab">Cemiplimab</a></li> <li><a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Eldelumab" title="Eldelumab">Eldelumab</a></li> <li><a href="/wiki/Emapalumab" title="Emapalumab">Emapalumab</a></li> <li><a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Golimumab" title="Golimumab">Golimumab</a></li> <li><a href="/wiki/Ianalumab" title="Ianalumab">Ianalumab</a><sup>†</sup></li> <li><a href="/wiki/Lanadelumab" title="Lanadelumab">Lanadelumab</a></li> <li><a href="/wiki/Lenzilumab" title="Lenzilumab">Lenzilumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Lirentelimab" title="Lirentelimab">Lirentelimab</a></li> <li><a href="/wiki/Lirilumab" title="Lirilumab">Lirilumab</a></li> <li><a href="/wiki/Mavrilimumab" title="Mavrilimumab">Mavrilimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li> <li><a href="/wiki/Morolimumab" title="Morolimumab">Morolimumab</a></li> <li><a href="/wiki/Namilumab" title="Namilumab">Namilumab</a></li> <li><a href="/wiki/Oleclumab" title="Oleclumab">Oleclumab</a></li> <li><a href="/wiki/Oxelumab" title="Oxelumab">Oxelumab</a>§</li> <li><a href="/wiki/Pamrevlumab" title="Pamrevlumab">Pamrevlumab</a></li> <li><a href="/wiki/Placulumab" title="Placulumab">Placulumab</a></li> <li><a href="/wiki/Relatlimab" title="Relatlimab">Relatlimab</a><sup>†</sup></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Sifalimumab" title="Sifalimumab">Sifalimumab</a></li> <li><a href="/wiki/Tabalumab" title="Tabalumab">Tabalumab</a></li> <li><a href="/wiki/Tezepelumab" title="Tezepelumab">Tezepelumab</a></li> <li><a href="/wiki/Ulocuplumab" title="Ulocuplumab">Ulocuplumab</a></li> <li><a href="/wiki/Varlilumab" title="Varlilumab">Varlilumab</a></li></ul> <ul><li><i>Immune activation</i>: <a href="/wiki/Ipilimumab" title="Ipilimumab">Ipilimumab</a></li> <li><a href="/wiki/Durvalumab" title="Durvalumab">Durvalumab</a></li> <li><a href="/wiki/Nivolumab" title="Nivolumab">Nivolumab</a></li> <li><a href="/wiki/Tremelimumab" title="Tremelimumab">Tremelimumab</a></li> <li><a href="/wiki/Urelumab" title="Urelumab">Urelumab</a></li></ul> <ul><li><i>Other</i>: <a href="/wiki/Bertilimumab" title="Bertilimumab">Bertilimumab</a></li> <li><a href="/w/index.php?title=Ontamalimab&action=edit&redlink=1" class="new" title="Ontamalimab (page does not exist)">Ontamalimab</a></li> <li><a href="/wiki/Zanolimumab" title="Zanolimumab">Zanolimumab</a></li></ul> <ul><li><i>Combination</i>: <a href="/wiki/Nivolumab/relatlimab" title="Nivolumab/relatlimab">Nivolumab/relatlimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Mouse</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Afelimomab" title="Afelimomab">Afelimomab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/wiki/Faralimomab" title="Faralimomab">Faralimomab</a></li> <li><a href="/wiki/Gavilimomab" title="Gavilimomab">Gavilimomab</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li> <li><a href="/wiki/Maslimomab" title="Maslimomab">Maslimomab</a></li> <li><a href="/wiki/Nerelimomab" title="Nerelimomab">Nerelimomab</a></li> <li><a href="/wiki/Odulimomab" title="Odulimomab">Odulimomab</a></li> <li><a href="/wiki/Telimomab_aritox" title="Telimomab aritox">Telimomab aritox</a></li> <li><a href="/wiki/Vepalimomab" title="Vepalimomab">Vepalimomab</a></li> <li><a href="/wiki/Zolimomab_aritox" title="Zolimomab aritox">Zolimomab aritox</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chimeric_antibody" class="mw-redirect" title="Chimeric antibody">Chimeric</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Andecaliximab" title="Andecaliximab">Andecaliximab</a><sup>†</sup></li> <li><a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Clenoliximab" title="Clenoliximab">Clenoliximab</a></li> <li><a href="/wiki/Galiximab" title="Galiximab">Galiximab</a></li> <li><a href="/wiki/Gomiliximab" class="mw-redirect" title="Gomiliximab">Gomiliximab</a></li> <li><a href="/wiki/Infliximab" title="Infliximab">Infliximab</a></li> <li><a href="/wiki/Keliximab" title="Keliximab">Keliximab</a></li> <li><a href="/wiki/Lumiliximab" title="Lumiliximab">Lumiliximab</a></li> <li><a href="/wiki/Priliximab" title="Priliximab">Priliximab</a></li> <li><a href="/wiki/Teneliximab" title="Teneliximab">Teneliximab</a></li> <li><a href="/wiki/Vapaliximab" title="Vapaliximab">Vapaliximab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Humanized_antibody" title="Humanized antibody">Humanized</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Immunosuppressive:</i> <a href="/wiki/Apolizumab" title="Apolizumab">Apolizumab</a><sup>§</sup></li> <li><a href="/wiki/Aselizumab" title="Aselizumab">Aselizumab</a></li> <li><a href="/wiki/Atezolizumab" title="Atezolizumab">Atezolizumab</a></li> <li><a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Camrelizumab" title="Camrelizumab">Camrelizumab</a><sup>†</sup></li> <li><a href="/wiki/Cedelizumab" title="Cedelizumab">Cedelizumab</a></li> <li><a href="/wiki/Certolizumab_pegol" title="Certolizumab pegol">Certolizumab pegol</a></li> <li><a href="/wiki/Crizanlizumab" title="Crizanlizumab">Crizanlizumab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab</a></li> <li><a href="/wiki/Eculizumab" title="Eculizumab">Eculizumab</a></li> <li><a href="/wiki/Efalizumab" title="Efalizumab">Efalizumab</a><sup>‡</sup></li> <li><a href="/wiki/Epratuzumab" title="Epratuzumab">Epratuzumab</a></li> <li><a href="/wiki/Erlizumab" title="Erlizumab">Erlizumab</a></li> <li><a href="/wiki/Etrolizumab" title="Etrolizumab">Etrolizumab</a><sup>†</sup></li> <li><a href="/wiki/Fontolizumab" title="Fontolizumab">Fontolizumab</a></li> <li><a href="/wiki/Frexalimab" title="Frexalimab">Frexalimab</a><sup>†</sup></li> <li><a href="/wiki/Inebilizumab" title="Inebilizumab">Inebilizumab</a></li> <li><a href="/wiki/Itolizumab" title="Itolizumab">Itolizumab</a></li> <li><a href="/wiki/Lampalizumab" title="Lampalizumab">Lampalizumab</a><sup>†</sup></li> <li><a href="/wiki/Letolizumab" title="Letolizumab">Letolizumab</a></li> <li><a href="/wiki/Ligelizumab" title="Ligelizumab">Ligelizumab</a><sup>†</sup></li> <li><a href="/wiki/Lulizumab_pegol" title="Lulizumab pegol">Lulizumab pegol</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Mogamulizumab" title="Mogamulizumab">Mogamulizumab</a></li> <li><a href="/wiki/Natalizumab" title="Natalizumab">Natalizumab</a></li> <li><a href="/wiki/Ocrelizumab" title="Ocrelizumab">Ocrelizumab</a> (<a href="/wiki/Ocrelizumab/hyaluronidase" title="Ocrelizumab/hyaluronidase">+hyaluronidase</a>)</li> <li><a href="/wiki/Omalizumab" title="Omalizumab">Omalizumab</a></li> <li><a href="/wiki/Ozoralizumab" title="Ozoralizumab">Ozoralizumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li> <li><a href="/wiki/Pateclizumab" title="Pateclizumab">Pateclizumab</a></li> <li><a href="/wiki/Pembrolizumab" title="Pembrolizumab">Pembrolizumab</a></li> <li><a href="/wiki/Pexelizumab" title="Pexelizumab">Pexelizumab</a></li> <li><a href="/wiki/Pidilizumab" title="Pidilizumab">Pidilizumab</a></li> <li><a href="/wiki/Plozalizumab" title="Plozalizumab">Plozalizumab</a></li> <li><a href="/wiki/PRO_140" class="mw-redirect" title="PRO 140">PRO 140</a><sup>†</sup></li> <li><a href="/wiki/Quilizumab" title="Quilizumab">Quilizumab</a></li> <li><a href="/wiki/Ravulizumab" title="Ravulizumab">Ravulizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li> <li><a href="/wiki/Retifanlimab" title="Retifanlimab">Retifanlimab</a></li> <li><a href="/wiki/Rontalizumab" title="Rontalizumab">Rontalizumab</a></li> <li><a href="/wiki/Rovelizumab" title="Rovelizumab">Rovelizumab</a></li> <li><a href="/wiki/Ruplizumab" title="Ruplizumab">Ruplizumab</a></li> <li><a href="/wiki/Samalizumab" title="Samalizumab">Samalizumab</a></li> <li><a href="/wiki/Satralizumab" title="Satralizumab">Satralizumab</a></li> <li><a href="/wiki/Siplizumab" title="Siplizumab">Siplizumab</a></li> <li><a href="/wiki/Spartalizumab" title="Spartalizumab">Spartalizumab</a><sup>†</sup></li> <li><a href="/wiki/Talizumab" title="Talizumab">Talizumab</a></li> <li><a href="/wiki/Teclistamab" title="Teclistamab">Teclistamab</a></li> <li><a href="/wiki/Teplizumab" title="Teplizumab">Teplizumab</a></li> <li><a href="/wiki/Tislelizumab" title="Tislelizumab">Tislelizumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Toralizumab" title="Toralizumab">Toralizumab</a></li> <li><a href="/wiki/Tregalizumab" title="Tregalizumab">Tregalizumab</a></li> <li><a href="/wiki/Vatelizumab" title="Vatelizumab">Vatelizumab</a></li> <li><a href="/wiki/Vedolizumab" title="Vedolizumab">Vedolizumab</a></li> <li><a href="/wiki/Visilizumab" title="Visilizumab">Visilizumab</a></li> <li><a href="/wiki/Vobarilizumab" title="Vobarilizumab">Vobarilizumab</a></li> <li><a href="/wiki/TGN1412" class="mw-redirect" title="TGN1412">TGN1412</a><sup>§</sup><br /></li></ul> <p><i>Immune activation</i>: <a href="/wiki/Dostarlimab" title="Dostarlimab">Dostarlimab</a><br /> <i>Other:</i> <a href="/wiki/Ibalizumab" title="Ibalizumab">Ibalizumab</a> </p> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Chimeric + humanized<br /></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Otelixizumab" title="Otelixizumab">Otelixizumab</a></li> <li><a href="/wiki/Rozanolixizumab" title="Rozanolixizumab">Rozanolixizumab</a></li> <li><a href="/wiki/Sutimlimab" title="Sutimlimab">Sutimlimab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Human</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bermekimab" title="Bermekimab">Bermekimab</a></li> <li><a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a></li> <li><a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Humanized</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Bimekizumab" title="Bimekizumab">Bimekizumab</a></li> <li><a class="mw-selflink selflink">Clazakizumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Mirikizumab" title="Mirikizumab">Mirikizumab</a><sup>†</sup></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a><sup>†</sup></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Spesolimab" title="Spesolimab">Spesolimab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Veterinary</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lokivetmab" title="Lokivetmab">Lokivetmab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="text-align:center;;width:1%">Inflammatory <a href="/wiki/Lesion" title="Lesion">lesions</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Mouse5" scope="row" class="navbox-group" style="width:1%;text-align:center;">Mouse</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Besilesomab" title="Besilesomab">Besilesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_fanolesomab" title="Technetium (99mTc) fanolesomab">Fanolesomab</a><sup>‡</sup></li> <li><a href="/wiki/Lemalesomab" title="Lemalesomab">Lemalesomab</a></li> <li><a href="/wiki/Technetium_(99mTc)_sulesomab" title="Technetium (99mTc) sulesomab">Sulesomab</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="text-align:center;;padding: 0px;"><div><div class="hlist"> <ul><li><sup>#</sup><a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li><sup>‡</sup><a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li><sup>†</sup><a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li><sup>§</sup>Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators601" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators601" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a class="mw-selflink selflink">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_7" title="Interleukin 7">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_17" title="Interleukin 17">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Clazakizumab&oldid=1187917121">https://en.wikipedia.org/w/index.php?title=Clazakizumab&oldid=1187917121</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Drugs_not_assigned_an_ATC_code" title="Category:Drugs not assigned an ATC code">Drugs not assigned an ATC code</a></li><li><a href="/wiki/Category:Drugs_developed_by_Bristol_Myers_Squibb" title="Category:Drugs developed by Bristol Myers Squibb">Drugs developed by Bristol Myers Squibb</a></li><li><a href="/wiki/Category:Antibodies" title="Category:Antibodies">Antibodies</a></li><li><a href="/wiki/Category:Experimental_monoclonal_antibodies" title="Category:Experimental monoclonal antibodies">Experimental monoclonal antibodies</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:Short_description_is_different_from_Wikidata" title="Category:Short description is different from Wikidata">Short description is different from Wikidata</a></li><li><a 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