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<span>Function</span> </div> </a> <button aria-controls="toc-Function-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Function subsection</span> </button> <ul id="toc-Function-sublist" class="vector-toc-list"> <li id="toc-Lymphocyte_maturation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Lymphocyte_maturation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Lymphocyte maturation</span> </div> </a> <ul id="toc-Lymphocyte_maturation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-IL-7_signaling" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#IL-7_signaling"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>IL-7 signaling</span> </div> </a> <ul id="toc-IL-7_signaling-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li 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Available in 16 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-16" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">16 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A7%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%83%D9%8A%D9%86_7" title="انترلوكين 7 – Arabic" lang="ar" hreflang="ar" data-title="انترلوكين 7" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Interleukin_7" title="Interleukin 7 – Czech" lang="cs" hreflang="cs" data-title="Interleukin 7" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/IL7" title="IL7 – Welsh" lang="cy" hreflang="cy" data-title="IL7" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Interleucina_7" title="Interleucina 7 – Spanish" lang="es" hreflang="es" data-title="Interleucina 7" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86_%DB%B7" title="اینترلوکین ۷ – Persian" lang="fa" hreflang="fa" data-title="اینترلوکین ۷" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interleukine_7" title="Interleukine 7 – French" lang="fr" hreflang="fr" data-title="Interleukine 7" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina_7" title="Interleucina 7 – Galician" lang="gl" hreflang="gl" data-title="Interleucina 7" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchina_7" title="Interleuchina 7 – Italian" lang="it" hreflang="it" data-title="Interleuchina 7" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3-7" title="インターロイキン-7 – Japanese" lang="ja" hreflang="ja" data-title="インターロイキン-7" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_7" title="Interleukina 7 – Polish" lang="pl" hreflang="pl" data-title="Interleukina 7" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_7" title="Interleucina 7 – Portuguese" lang="pt" hreflang="pt" data-title="Interleucina 7" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B9%D0%BA%D0%B8%D0%BD_7" title="Интерлейкин 7 – Russian" lang="ru" hreflang="ru" data-title="Интерлейкин 7" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_7" title="Интерлеукин 7 – Serbian" lang="sr" hreflang="sr" data-title="Интерлеукин 7" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin_7" title="Interleukin 7 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Interleukin 7" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%86%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B9%D0%BA%D1%96%D0%BD-7" title="Інтерлейкін-7 – Ukrainian" lang="uk" hreflang="uk" data-title="Інтерлейкін-7" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh 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class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Growth factor secreted by stromal cells in the bone marrow and thymus.</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">IL7</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_IL7_PDB_1IL7.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Protein_IL7_PDB_1IL7.png/250px-Protein_IL7_PDB_1IL7.png" decoding="async" width="250" height="208" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Protein_IL7_PDB_1IL7.png/375px-Protein_IL7_PDB_1IL7.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Protein_IL7_PDB_1IL7.png/500px-Protein_IL7_PDB_1IL7.png 2x" data-file-width="1200" data-file-height="1000" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P10168%20or%20P13232">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P10168,P13232">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3DI2">3DI2</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3DI3">3DI3</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6023">IL7</a></span>, IL-7, interleukin 7</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/146660">146660</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96561">96561</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=680">680</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL7">IL7</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000104432">IL7 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_8.svg" class="mw-file-description" title="Chromosome 8 (human)"><img alt="Chromosome 8 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/Ideogram_human_chromosome_8.svg/300px-Ideogram_human_chromosome_8.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/60/Ideogram_human_chromosome_8.svg/450px-Ideogram_human_chromosome_8.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/60/Ideogram_human_chromosome_8.svg/600px-Ideogram_human_chromosome_8.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_8_(human)" class="mw-redirect" title="Chromosome 8 (human)">Chromosome 8 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_8_ideogram.svg" class="mw-file-description" title="Chromosome 8 (human)"><img alt="Chromosome 8 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/37/Human_chromosome_8_ideogram.svg/300px-Human_chromosome_8_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/37/Human_chromosome_8_ideogram.svg/450px-Human_chromosome_8_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/37/Human_chromosome_8_ideogram.svg/600px-Human_chromosome_8_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 154.17318459515px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IL7"><img alt="Genomic location for IL7" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 160.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IL7"><img alt="Genomic location for IL7" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">8q21.13</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">78,675,743 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">78,805,523 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/390px-Ideogram_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/520px-Ideogram_house_mouse_chromosome_3.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 3 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (mouse)"><img alt="Chromosome 3 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/300px-Ideogram_of_house_mouse_chromosome_3.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/450px-Ideogram_of_house_mouse_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_3.svg/600px-Ideogram_of_house_mouse_chromosome_3.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 8.6725061560258px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IL7"><img alt="Genomic location for IL7" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 14.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IL7"><img alt="Genomic location for IL7" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">3 A1|3 2.02 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">7,635,054 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">7,678,820 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000104432">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">sperm</li><br /><li style="line-height: 137%;">bronchial epithelial cell</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">Achilles tendon</li><br /><li style="line-height: 137%;">jejunal mucosa</li><br /><li style="line-height: 137%;">lower lobe of lung</li><br /><li style="line-height: 137%;">caput epididymis</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">right uterine tube</li><br /><li style="line-height: 137%;">rectum</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000040329">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">lumbar spinal ganglion</li><br /><li style="line-height: 137%;">zygote</li><br /><li style="line-height: 137%;">primary oocyte</li><br /><li style="line-height: 137%;">endothelial cell of lymphatic vessel</li><br /><li style="line-height: 137%;">thymus</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">left colon</li><br /><li style="line-height: 137%;">Paneth cell</li><br /><li style="line-height: 137%;">stroma of bone marrow</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000104432">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_IL7_206693_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_IL7_206693_at_fs.png/250px-PBB_GE_IL7_206693_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_IL7_206693_at_fs.png/375px-PBB_GE_IL7_206693_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/ba/PBB_GE_IL7_206693_at_fs.png/500px-PBB_GE_IL7_206693_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/3574/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005139">interleukin-7 receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008083">growth factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005126">cytokine receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005125">cytokine activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0062023">collagen-containing extracellular matrix</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043086">negative regulation of catalytic activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007267">cell-cell signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001237">negative regulation of extrinsic apoptotic signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046622">positive regulation of organ growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045453">bone resorption</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006959">humoral immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006955">immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009887">animal organ morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010468">regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048873">homeostasis of number of cells within a tissue</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001240">negative regulation of extrinsic apoptotic signaling pathway in absence of ligand</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002360">T cell lineage commitment</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030890">positive regulation of B cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045582">positive regulation of T cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038111">interleukin-7-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001961">positive regulation of cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032722">positive regulation of chemokine production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050730">regulation of peptidyl-tyrosine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010628">positive regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045579">positive regulation of B cell differentiation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3574&rn=1">3574</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=16196&rn=1">16196</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000104432;db=core">ENSG00000104432</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000040329;db=core">ENSMUSG00000040329</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P13232">P13232</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P10168">P10168</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000880">NM_000880</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001199886">NM_001199886</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001199887">NM_001199887</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001199888">NM_001199888</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008371">NM_008371</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001313888">NM_001313888</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001313889">NM_001313889</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001313890">NM_001313890</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000871">NP_000871</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001186815">NP_001186815</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001186816">NP_001186816</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001186817">NP_001186817</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001300817">NP_001300817</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001300818">NP_001300818</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001300819">NP_001300819</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032397">NP_032397</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr8:78675743-78805523">Chr 8: 78.68 – 78.81 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr3:7635054-7678820">Chr 3: 7.64 – 7.68 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14889532" class="extiw" title="d:Q14889532">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14889533" class="extiw" title="d:Q14889533">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Interleukin 7</b> (<b>IL-7</b>) is a <a href="/wiki/Protein" title="Protein">protein</a><sup id="cite_ref-pmid3259677_5-0" class="reference"><a href="#cite_note-pmid3259677-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> that in humans is encoded by the <i>IL7</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid2643102_6-0" class="reference"><a href="#cite_note-pmid2643102-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2786840_7-0" class="reference"><a href="#cite_note-pmid2786840-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>IL-7 is a <a href="/wiki/Haematopoiesis" title="Haematopoiesis">hematopoietic</a> <a href="/wiki/Growth_factor" title="Growth factor">growth factor</a> secreted by <a href="/wiki/Stromal_cell" title="Stromal cell">stromal cells</a> in the <a href="/wiki/Bone_marrow" title="Bone marrow">bone marrow</a> and <a href="/wiki/Thymus" title="Thymus">thymus</a>. It is also produced by <a href="/wiki/Keratinocyte" title="Keratinocyte">keratinocytes</a>,<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Follicular_dendritic_cell" class="mw-redirect" title="Follicular dendritic cell">follicular dendritic cells</a>,<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Hepatocyte" title="Hepatocyte">hepatocytes</a>,<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Neuron" title="Neuron">neurons</a>, and <a href="/wiki/Epithelial_cells" class="mw-redirect" title="Epithelial cells">epithelial cells</a>,<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> but is not produced by normal <a href="/wiki/Lymphocyte" title="Lymphocyte">lymphocytes</a>.<sup id="cite_ref-Fry_TJ,_Mackall_CL_2002_3892–904_13-0" class="reference"><a href="#cite_note-Fry_TJ,_Mackall_CL_2002_3892–904-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> A study also demonstrated how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading. <sup id="cite_ref-pmid31417180_14-0" class="reference"><a href="#cite_note-pmid31417180-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The three-dimensional structure of IL-7 in complex with the <a href="/wiki/Ectodomain" title="Ectodomain">ectodomain</a> of <a href="/wiki/IL-7_receptor" class="mw-redirect" title="IL-7 receptor">IL-7 receptor</a> has been determined using <a href="/wiki/X-ray_crystallography#Biological_macromolecular_crystallography" title="X-ray crystallography">X-ray diffraction</a>.<sup id="cite_ref-pmid19141282_15-0" class="reference"><a href="#cite_note-pmid19141282-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Lymphocyte_maturation">Lymphocyte maturation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=3" title="Edit section: Lymphocyte maturation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic <a href="/wiki/Stem_cell" title="Stem cell">stem cells</a> into <a href="/wiki/Lymphoid_progenitor_cell" class="mw-redirect" title="Lymphoid progenitor cell">lymphoid progenitor cells</a> (as opposed to myeloid progenitor cells where differentiation is stimulated by <a href="/wiki/Interleukin_3" title="Interleukin 3">IL-3</a>).<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2011)">citation needed</span></a></i>]</sup> It also stimulates proliferation of all cells in the lymphoid lineage (<a href="/wiki/B_cell" title="B cell">B cells</a>, <a href="/wiki/T_cell" title="T cell">T cells</a> and <a href="/wiki/Natural_killer_cell" title="Natural killer cell">NK cells</a>).<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2011)">citation needed</span></a></i>]</sup> It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and <a href="/wiki/Homeostasis" title="Homeostasis">homeostasis</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2011)">citation needed</span></a></i>]</sup> </p><p>IL-7 is a <a href="/wiki/Cytokine" title="Cytokine">cytokine</a> important for B and T cell development. This cytokine and the hepatocyte growth factor (<a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">HGF</a>) form a <a href="/wiki/Heterodimer" class="mw-redirect" title="Heterodimer">heterodimer</a> that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> This cytokine can be produced locally by intestinal epithelial and epithelial <a href="/wiki/Goblet_cell" title="Goblet cell">goblet cells</a>, and may serve as a regulatory factor for intestinal mucosal lymphocytes.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (February 2011)">citation needed</span></a></i>]</sup> <a href="/wiki/Knockout_studies" class="mw-redirect" title="Knockout studies">Knockout studies</a> in mice suggested that this cytokine plays an essential role in lymphoid cell survival.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="IL-7_signaling">IL-7 signaling</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=4" title="Edit section: IL-7 signaling"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-left" typeof="mw:File/Thumb"><a href="/wiki/File:IL-7receptor_and_signaling.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/IL-7receptor_and_signaling.jpg/300px-IL-7receptor_and_signaling.jpg" decoding="async" width="300" height="345" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/IL-7receptor_and_signaling.jpg/450px-IL-7receptor_and_signaling.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a7/IL-7receptor_and_signaling.jpg/600px-IL-7receptor_and_signaling.jpg 2x" data-file-width="606" data-file-height="696" /></a><figcaption><b>IL-7 receptor and signaling</b>, common γ chain (blue) and IL-7 receptor-α (green)</figcaption></figure> <p>IL-7 binds to the <a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7 receptor</a>, a heterodimer consisting of <a href="/wiki/CD127" class="mw-redirect" title="CD127">Interleukin-7 receptor alpha</a> and <a href="/wiki/CD132" class="mw-redirect" title="CD132">common gamma chain receptor</a>.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Binding results in a cascade of signals important for T-cell development within the thymus and survival within the periphery. Knockout mice which genetically lack IL-7 receptor exhibit thymic <a href="/wiki/Atrophy" title="Atrophy">atrophy</a>, arrest of T-cell development at the double positive stage, and severe <a href="/wiki/Lymphopenia" class="mw-redirect" title="Lymphopenia">lymphopenia</a>. Administration of IL-7 to mice results in an increase in recent thymic emigrants, increases in B and T cells, and increased recovery of T cells after <a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">cyclophosphamide</a> administration or after bone marrow transplantation. </p> <div class="mw-heading mw-heading2"><h2 id="Disease">Disease</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=5" title="Edit section: Disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=6" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-7 promotes hematological malignancies (acute lymphoblastic leukemia, T cell lymphoma).<sup id="cite_ref-pmid10068062_19-0" class="reference"><a href="#cite_note-pmid10068062-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Viral_Infections">Viral Infections</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=7" title="Edit section: Viral Infections"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Elevated levels of IL-7 have also been detected in the plasma of <a href="/wiki/HIV" title="HIV">HIV-infected patients</a>.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_application">Clinical application</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=8" title="Edit section: Clinical application"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-7 as an <a href="/wiki/Immunotherapy" title="Immunotherapy">immunotherapy</a> agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during <a href="/wiki/HIV" title="HIV">HIV infection</a>.<sup id="cite_ref-Fry_TJ,_Mackall_CL_2002_3892–904_13-1" class="reference"><a href="#cite_note-Fry_TJ,_Mackall_CL_2002_3892–904-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cancer_2">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=9" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Recombinant_DNA" title="Recombinant DNA">Recombinant</a> IL-7 has been safely administered to patients in several phase I and II <a href="/wiki/Clinical_trials" class="mw-redirect" title="Clinical trials">clinical trials</a>. A human study of IL-7 in patients with <a href="/wiki/Cancer" title="Cancer">cancer</a> demonstrated that administration of this cytokine can transiently disrupt the homeostasis of both CD8+ and CD4+ T cells with a commensurate decrease in the percentage of CD4+CD25+Foxp3+ T regulatory cells.<sup id="cite_ref-pmid16699374_22-0" class="reference"><a href="#cite_note-pmid16699374-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> No objective cancer regression was observed, however a <a href="/w/index.php?title=Dose_limiting_toxicity&action=edit&redlink=1" class="new" title="Dose limiting toxicity (page does not exist)">dose limiting toxicity</a> (DLT) was not reached in this study due to the development of neutralizing <a href="/wiki/Antibodies" class="mw-redirect" title="Antibodies">antibodies</a> against the <a href="/wiki/Recombinant_cytokine" class="mw-redirect" title="Recombinant cytokine">recombinant cytokine</a>. </p> <div class="mw-heading mw-heading3"><h3 id="HIV_infection">HIV infection</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=10" title="Edit section: HIV infection"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Associated with antiretroviral therapy, IL-7 administration decreased local and systemic inflammations in patients that had incomplete T-cell reconstitution. These results suggest that IL-7 therapy can possibly improve the quality of life of those patients.<sup id="cite_ref-IL7HIV_23-0" class="reference"><a href="#cite_note-IL7HIV-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Transplantation">Transplantation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=11" title="Edit section: Transplantation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-7 could also be beneficial in improving immune recovery after allogenic <a href="/wiki/Stem_cell" title="Stem cell">stem cell</a> transplant.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_7&action=edit&section=12" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 35em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000104432">GRCh38: Ensembl release 89: ENSG00000104432</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span 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"Stimulation of B-cell progenitors by cloned murine interleukin-7". <i>Nature</i>. <b>333</b> (6173): <span class="nowrap">571–</span>3. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1988Natur.333..571N">1988Natur.333..571N</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F333571a0">10.1038/333571a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3259677">3259677</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4315541">4315541</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Stimulation+of+B-cell+progenitors+by+cloned+murine+interleukin-7&rft.volume=333&rft.issue=6173&rft.pages=%3Cspan+class%3D%22nowrap%22%3E571-%3C%2Fspan%3E3&rft.date=1988-06&rft_id=info%3Adoi%2F10.1038%2F333571a0&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A4315541%23id-name%3DS2CID&rft_id=info%3Apmid%2F3259677&rft_id=info%3Abibcode%2F1988Natur.333..571N&rft.aulast=Namen&rft.aufirst=AE&rft.au=Lupton%2C+S&rft.au=Hjerrild%2C+K&rft.au=Wignall%2C+J&rft.au=Mochizuki%2C+DY&rft.au=Schmierer%2C+A&rft.au=Mosley%2C+B&rft.au=March%2C+CJ&rft.au=Urdal%2C+D&rft.au=Gillis%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+7" class="Z3988"></span></span> </li> <li id="cite_note-pmid2643102-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid2643102_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGoodwinLuptonSchmiererHjerrild1989" class="citation journal cs1">Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE (January 1989). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC286452">"Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells"</a>. <i>Proc. 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Biology and implications for dermatology"</a>. <i>Exp. 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clin.+Exp.+Immunol.&rft.atitle=Expansion+of+restricted+cellular+immune+responses+to+HIV-1+envelope+by+vaccination%3A+IL-7+and+IL-12+differentially+augment+cellular+proliferative+responses+to+HIV-1&rft.volume=108&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E243-%3C%2Fspan%3E50&rft.date=1997&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1904649%23id-name%3DPMC&rft_id=info%3Apmid%2F9158092&rft_id=info%3Adoi%2F10.1046%2Fj.1365-2249.1997.d01-1006.x&rft.aulast=Kim&rft.aufirst=JH&rft.au=Loveland%2C+JE&rft.au=Sitz%2C+KV&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1904649&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+7" class="Z3988"></span></li></ul> </div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist 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href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CXCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CXCL1" title="CXCL1">CXCL1</a>/KC</li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">CXCL4</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/wiki/Interleukin_8" title="Interleukin 8">CXCL8/IL8</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11</a></li> <li><a href="/wiki/SDF-1_(biology)" class="mw-redirect" title="SDF-1 (biology)">CXCL12</a></li> <li><a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li> <li><a href="/wiki/CXCL14" title="CXCL14">CXCL14</a></li> <li><a href="/wiki/CXCL15" title="CXCL15">CXCL15</a></li> <li><a href="/wiki/CXCL16" title="CXCL16">CXCL16</a></li> <li><a href="/wiki/CXCL17" title="CXCL17">CXCL17</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CX3CL</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CX3CL1" title="CX3CL1">CX3CL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">XCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/XCL1" title="XCL1">XCL1</a></li> <li><a href="/wiki/XCL2" title="XCL2">XCL2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor_necrosis_factors" class="mw-redirect" title="Tumor necrosis factors">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li> <li><a href="/wiki/Lymphotoxin" title="Lymphotoxin">Lymphotoxin</a> <ul><li><a href="/wiki/Lymphotoxin_alpha" title="Lymphotoxin alpha">TNFB/LTA</a></li> <li><a href="/wiki/Lymphotoxin_beta" title="Lymphotoxin beta">TNFC/LTB</a></li></ul></li> <li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L">TNFSF4</a></li> <li><a href="/wiki/CD154" title="CD154">TNFSF5/CD40LG</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">TNFSF6</a></li> <li><a href="/wiki/CD70" title="CD70">TNFSF7</a></li> <li><a href="/wiki/CD153" title="CD153">TNFSF8</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">TNFSF9</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">TNFSF10</a></li> <li><a href="/wiki/RANKL" title="RANKL">TNFSF11</a></li> <li><a href="/wiki/A_proliferation-inducing_ligand" class="mw-redirect" title="A proliferation-inducing ligand">TNFSF13</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">TNFSF13B</a></li> <li><a href="/wiki/EDA_(gene)" class="mw-redirect" title="EDA (gene)">EDA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a><br />(grouped by<br />receptor<br />subunit)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_2" title="Interleukin 2">IL2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">IL15</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a>/<a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li> <li><a class="mw-selflink selflink">IL7</a></li> <li><a href="/wiki/Interleukin_9" title="Interleukin 9">IL9</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">IL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CSF2RB" title="CSF2RB">β chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_3" title="Interleukin 3">IL3</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">GMCSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">IL6 like/<a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_11" title="Interleukin 11">IL11</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_30" title="Interleukin 30">IL30</a></li> <li><a href="/wiki/Interleukin_31" title="Interleukin 31">IL31</a> <ul><li>+non IL <a href="/wiki/Oncostatin_M" title="Oncostatin M">OSM</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">LIF</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor" title="Ciliary neurotrophic factor">CNTF</a></li> <li><a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">CTF1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=IL12_family&action=edit&redlink=1" class="new" title="IL12 family (page does not exist)">IL12 family</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_12" title="Interleukin 12">IL12</a></li> <li><a href="/wiki/Interleukin_23" title="Interleukin 23">IL23</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">IL35</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-taxilin" title="Alpha-taxilin">IL14</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">IL16</a></li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">IL32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">IL34</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL10_family" class="mw-redirect" title="IL10 family">IL10 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a>/<a href="/wiki/Interleukin_22" title="Interleukin 22">IL22</a></li> <li><a href="/wiki/Interleukin_19" title="Interleukin 19">IL19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">IL20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">IL24</a></li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">IL26</a></li> <li><a href="/wiki/Interferon_type_III" title="Interferon type III">Interferon type III</a> <ul><li><a href="/wiki/Interleukin_28" title="Interleukin 28">IL28/IFNL2+3</a></li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">IL29/IFNL1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon" title="Interferon">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_I" title="Interferon type I">I</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a></li> <li><a href="/wiki/IFNA2" title="IFNA2">IFNA2</a></li> <li><a href="/wiki/IFNA4" title="IFNA4">IFNA4</a></li> <li><a href="/wiki/IFNA5" title="IFNA5">IFNA5</a></li> <li><a href="/wiki/IFNA6" title="IFNA6">IFNA6</a></li> <li><a href="/wiki/IFNA7" title="IFNA7">IFNA7</a></li> <li><a href="/wiki/IFNA8" title="IFNA8">IFNA8</a></li> <li><a href="/wiki/IFNA10" title="IFNA10">IFNA10</a></li> <li><a href="/wiki/IFNA13" title="IFNA13">IFNA13</a></li> <li><a href="/wiki/IFNA14" title="IFNA14">IFNA14</a></li> <li><a href="/wiki/IFNA16" title="IFNA16">IFNA16</a></li> <li><a href="/wiki/IFNA17" title="IFNA17">IFNA17</a></li> <li><a href="/wiki/IFNA21" title="IFNA21">IFNA21</a></li> <li><a href="/wiki/IFNB1" title="IFNB1">IFNB1</a></li> <li><a href="/wiki/IFNK" title="IFNK">IFNK</a></li> <li><a href="/wiki/IFNW1" title="IFNW1">IFNW1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_II" class="mw-redirect" title="Interferon type II">II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNG</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_1_family" class="mw-redirect" title="Interleukin 1 family">IL1 family</a>: <a href="/wiki/IL1A" class="mw-redirect" title="IL1A">IL1A/IL1F1</a></li> <li><a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">IL1B/IL1F2</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">1Ra/IL1F3</a></li> <li><a href="/wiki/IL1F5" class="mw-redirect" title="IL1F5">IL1F5</a></li> <li><a href="/wiki/IL36A" title="IL36A">IL1F6</a></li> <li><a href="/wiki/IL1F7" class="mw-redirect" title="IL1F7">IL1F7</a></li> <li><a href="/wiki/IL36B" title="IL36B">IL1F8</a></li> <li><a href="/wiki/IL1F9" class="mw-redirect" title="IL1F9">IL1F9</a></li> <li><a href="/wiki/IL1F10" title="IL1F10">IL1F10</a></li> <li><a href="/wiki/Interleukin_33" title="Interleukin 33">33/IL1F11</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">18/IL1G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL17_family" class="mw-redirect" title="IL17 family">IL17 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_17" title="Interleukin 17">IL17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">IL25</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hematopoietic" class="mw-redirect" title="Hematopoietic">Hematopoietic</a> <ul><li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">KITLG</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li></ul></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">SPP1</a></li> <li><a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By function/<br />cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Proinflammatory_cytokine" class="mw-redirect" title="Proinflammatory cytokine">proinflammatory cytokine</a></i> <ul><li><a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">IL1</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li></ul></li></ul> <ul><li><a href="/wiki/Monokine" title="Monokine">Monokine</a></li> <li><a href="/wiki/Lymphokine" title="Lymphokine">Lymphokine</a> <ul><li><i>T<sub>h</sub>1</i> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNγ</a></li> <li><a href="/wiki/Tumor_necrosis_factor_beta" class="mw-redirect" title="Tumor necrosis factor beta">TNFβ</a></li></ul></li> <li><i>T<sub>h</sub>2</i> <ul><li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li></ul></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators601" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators601" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a class="mw-selflink selflink">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_17" title="Interleukin 17">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" 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