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Translational research services - Patheon pharma services
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The use of suboptimal materials and processes in the discovery stage can significantly disrupt progression to later clinical stages, leading to timeline delays and increased costs.</p> <p>At Thermo Fisher Scientific, our translational research services help produce small-scale molecular biology, viral vector, and cell therapy materials utilizing scaled-down processes that mirror cGMP workflows. This helps to proactively mitigate risk and enhance the transition from discovery to clinical research and ultimately commercialization, enabling an accelerated timeline from bench to bedside.</p> </div> </div> <div class="cmp-button aem-GridColumn aem-GridColumn--default--12"> <div id="button-617437901" class="btn-wrapper"> <a class=" btn btn-style-primary icon-placement-left " href="https://www.patheon.com/us/en/about-us/contact-us/capabilities.html?interest=Translational%20research%20of%20viral%20vectors" role="button" target="_self"> Contact us </a> </div> <style> #button-617437901 .btn-style-quickLink { border-left: 6px solid #1E8AE7; } #button-617437901 { padding-right:0px; padding-left:0px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-406857759"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-406857759 { border-radius: 0px; } </style> </div> </div> </div> <style type="text/css"> #container-739700346{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-739700346 { border-radius: px; } </style> </div> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn aem-GridColumn--default--12"> <div id="text-37a197b403" class="cmp-text list-style-bullets"> <h3><b>A “start-with-end-in-mind” approach helps de-risk advanced therapy development</b></h3> </div> </div> <div class="text aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-eba132b8cf" class="cmp-text list-style-bullets"> <p>When embarking on a new cell- and gene-based therapy development project, it’s crucial to keep the end goal in mind: producing larger-scale, GMP-level batches that satisfy regulatory requirements to accelerate patient access to life-saving therapies. Translational services help achieve this goal through the early establishment of standardized processes and qualifiable assays that avoid delays during the transition to larger-scale, GMP-level production.</p> <p>Translational services offer:</p> <ul> <li>Access to emerging technologies through R&D, operational, and regulatory support</li> <li>Use of research use only (RUO) materials with cGMP-equivalent counterparts</li> <li>Qualified equipment, robust training, starting and raw materials vendor management, and processes to monitor performance drift</li> <li>Scaled-down processing models using qualified reagents and analytics</li> <li>Robust in-process testing and monitoring</li> <li>Methods based on the latest regulatory guidance, continuous understanding, and incorporation of regulatory requirements</li> </ul> </div> </div> </div> </div> </div> <style type="text/css"> #well-1294414984 { border-radius: 0px; } </style> </div> <div class="cmp-well aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--newline aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--newline aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--12"> <div class="well " style="background-position-x: center;background-position-y: center;" id="well-2047597298"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--xsmall--12 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-231453587"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-01184781d6" class="cmp-text list-style-bullets"> <p><i>Our translational research services generate material for research use only (RUO), not for IND-enabling studies or diagnostics purposes.</i></p> </div> </div> </div> </div> <style type="text/css"> #container-231453587{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-231453587 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn--xsmall--12 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 translational-services-container " id="container-2123765860"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="process-development"> <div class="accordion-item"> <div class="accordion-header" id="heading-process-development"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-process-development" aria-expanded="true" aria-controls="collapse-process-development"> <span> <span class="accordion-title">Molecular biology services</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-process-development" class="accordion-collapse collapse " aria-labelledby="heading-process-development" data-bs-parent="#process-development"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-496cc636e8" class="cmp-text list-style-bullets"> <p>Our molecular biology services support viral vector and cell therapy translational services to ensure high-quality/quantity materials generation and compliance with regulatory requirements. Specifically, our services include:</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner equalizeHeights h-100" id="container-487139156"> <div class="aem-Grid aem-Grid--6 aem-Grid--small--6 aem-Grid--default--6 aem-Grid--xsmall--6 aem-Grid--medium--12 "> <div class="text aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--offset--default--0 aem-GridColumn--offset--medium--0 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6"> <div id="text-7c58f08461" class="cmp-text list-style-check"> <p> </p> <ul style="color: rgb(38,34,98);margin-bottom: 0;"> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Plasmid modification or cloning (antibiotic resistance swapping, deletion/mutation of undesired sequence(s), etc.)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Plasmid production (up to 20 mg)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Plasmid purification (silica column, liquid chromatography)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Plasmid concentration and formulation (UF, TFF)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Standard analytics (quantity, integrity, purity)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Additional analytics (identity, purity, safety, etc.)</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-487139156{ background-image: url(''); 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background-color: ; background-size: cover; background-position: center; min-height: px; } #container-506549318 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-109096583"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-109096583 { border-radius: 0px; } </style> </div> <div class="text aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-b91061adb8" class="cmp-text list-style-bullets"> <p><b>Large-scale plasmid DNA manufacturing services<b></b></b></p> <p><b><b> </b></b></p> </div> </div> <div class="text aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-442d580121" class="cmp-text list-style-bullets"> <p>We produce plasmid DNA for a wide variety of R&D, clinical, and commercial bioprocessing applications. Plasmids can be manufactured by leveraging our proven platform process or via a customized production process. We can tailor our services for your unique molecule to improve its performance efficiency and scale up as needed.</p> <p>Learn more about our plasmid DNA manufacturing services <a href="https://www.patheon.com/us/en/our-capabilities/advanced-therapies/plasmid-manufacturing-services.html">here</a>.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-2123765860{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-2123765860 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn--xsmall--12 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 cgmp-plasmid-dna-container " id="container-1511263990"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="manufacturing-capabilities"> <div class="accordion-item"> <div class="accordion-header" id="heading-manufacturing-capabilities"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-manufacturing-capabilities" aria-expanded="true" aria-controls="collapse-manufacturing-capabilities"> <span> <span class="accordion-title">Viral vector translational services</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-manufacturing-capabilities" class="accordion-collapse collapse " aria-labelledby="heading-manufacturing-capabilities" data-bs-parent="#manufacturing-capabilities"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-0b1faef397" class="cmp-text list-style-bullets"> <p>Our viral vector translational services use standardized methods and scaled-down, cGMP-compatible processes for adeno-associated virus (AAV) and lentiviral (LV) production. Plasmids that are designed and engineered for purpose through molecular biology services are transfected in clonal, documented, and qualified HEK293 cell lines. The cells are grown in suspension and serum-free cell culture (up to 10L). Throughout the process, qualifiable analytics with controls and standards are utilized to characterize the viral vectors.</p> <p>Our viral vector translational services include:</p> </div> </div> <div class="cmp-container aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--offset--default--0 aem-GridColumn--offset--medium--0 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6"> <div class="cmp-container-inner p-3 equalizeHeights h-100" id="container-48426078"> <div class="aem-Grid aem-Grid--6 aem-Grid--small--12 aem-Grid--default--6 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--offset--default--0 aem-GridColumn--offset--medium--0 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6"> <div id="text-a05ccc7ebd" class="cmp-text list-style-check"> <ul style="color: rgb(38,34,98);margin-bottom: 0;"> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Cell expansion</b></li> <p> </p> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Plasmid transfection (transient transfection)</b></li> <p> </p> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Virus production (AAV, LV)</b></li> <p> </p> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Scale-specific virus purification (PEG concentration, affinity and ion-exchange chromatography, tangential flow filtration [TFF] concentration)<br /> <br /> </b></li> <li style="color: rgb(38,34,98);line-height: 170.0%;"><b>Characterization of viral vectors</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-48426078{ background-image: url(''); 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That includes process development, clinical and commercial manufacturing, fill/finish services, regulatory service, and cold chain logistics. Learn more about our end-to-end viral vector development and manufacturing solutions and 20+ years of industry experience <a href="https://www.patheon.com/us/en/our-capabilities/advanced-therapies/viral-vector-manufacturing-services.html">here</a>.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1511263990{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1511263990 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn--xsmall--12 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 viral-vector-services-accordion-container " id="container-1344406010"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="robust-analytics"> <div class="accordion-item"> <div class="accordion-header" id="heading-robust-analytics"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-robust-analytics" aria-expanded="true" aria-controls="collapse-robust-analytics"> <span> <span class="accordion-title">Cell therapy translational services</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-robust-analytics" class="accordion-collapse collapse " aria-labelledby="heading-robust-analytics" data-bs-parent="#robust-analytics"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--xsmall--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-741cedc8cf" class="cmp-text list-style-bullets"> <p>Our services enable the accelerated and effective translation of cell therapy research through the early establishment of standardized processes and qualifiable analytics. Our flexible, à la carte platform for immune and stem cells supports the optimization and establishment of your cell therapy manufacturing process with continual R&D, operational, and regulatory support.</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner py-3 " id="container-901011394"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--xsmall--12 "> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner equalizeHeights h-100" id="container-2002464460"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--offset--medium--0 aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner p-3 equalizeHeights h-100" id="container-2133959126"> <div class="aem-Grid aem-Grid--6 aem-Grid--small--12 aem-Grid--default--6 aem-Grid--medium--12 "> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="text-da32f020a4" class="cmp-text list-style-check"> <ul style="color: rgb(38,34,98);margin-bottom: 0;"> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Process optimization and establishment</b></li> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Proof-of-concept studies</b></li> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Raw material assessment</b></li> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Qualifiable analytics used in cGMP manufacturing</b></li> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Assay development and establishment</b></li> <li style="color: rgb(38,34,98);line-height: 350.0%;"><b>Quality management system</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-2133959126{ background-image: url(''); 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background-color: ; background-size: cover; background-position: center; min-height: px; } #container-870560498 { border-radius: px; } </style> </div> </div> </div> <style type="text/css"> #container-2002464460{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-2002464460 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-459879"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-459879 { border-radius: 0px; } </style> </div> <div class="text aem-GridColumn--xsmall--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-682a3f5a9e" class="cmp-text list-style-bullets"> <p>Our extensive experience working with stem cells and immune cell therapies allows for comprehensive workflow support (components, processing systems, in-process testing, analytics) to maximize the quality and efficiency of your translational therapy. </p> </div> </div> </div> </div> <style type="text/css"> #container-901011394{ background-image: url(''); 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background-color: ; background-size: cover; background-position: center; min-height: px; } #container-649984193 { border-radius: px; } </style> </div> </div> </div> <style type="text/css"> #container-2138679301{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-2138679301 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-530665504"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-530665504 { border-radius: 0px; } </style> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-a30422e79c" class="cmp-text list-style-bullets"> <p><b>End-to-end cell therapy development and manufacturing services</b></p> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-6e85dfbc0f" class="cmp-text list-style-bullets"> <p>In addition to cell therapy translational services, we provide support for all other aspects of the cell therapy development and manufacturing journey. Learn more about our end-to-end cell therapy development and manufacturing solutions <a href="https://www.patheon.com/us/en/our-capabilities/advanced-therapies/cgmp-cell-therapy-development-and-manufacturing-services.html">here</a>. </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1344406010{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1344406010 { border-radius: px; } </style> </div> </div> </div> </div> <style type="text/css"> #well-2047597298 { border-radius: 0px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " style="background-color: #FFFFFF;background-position-x: center;background-position-y: center;border-color: #FFFFFF;background-image: url('/content/dam/patheon/global/site-images/softgels/Made In Background Blue.png');" id="well-1145081954"> <div class="container-fluid container-lg p-5"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-141475143"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-18d093c521" class="cmp-text list-style-bullets"> <h3 style="color: rgb(255,255,255);"><b>Elevate your translational research with the industry’s leading research and development team</b></h3> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-1e2b774600" class="cmp-text list-style-bullets"> <p style="color: rgb(255,255,255);">Our dedicated advanced therapy research and development team of 60+ members — including more than 20 PhD scientists spanning diverse disciplines such as virology, biochemistry, molecular biology, cell biology, and microbiology — is committed to advancing the cell and gene therapy development and manufacturing landscape.<br /> </p> <p style="color: rgb(255,255,255);">Our mission involves the meticulous engineering of next-generation viral and non-viral vector, cell therapy, and plasmid DNA platforms, as well as developing more precise and qualifiable analytical assays. We are also establishing new benchmarks for quality standards and extending regulatory support for cGMP manufacturing.</p> <p style="color: rgb(255,255,255);">Our industry-leading knowledge and expertise is also utilized to consult and support early-stage developers through our translational research services.</p> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-1d78f33d24" class="cmp-text list-style-bullets"> <p style="color: rgb(255,255,255);">Gain insight into our team's recent scientific publications:</p> <ul> <li style="color: rgb(255,255,255);"><a href="https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00513?" target="_blank" style="color: rgb(255,255,255);"><u>Development of a rapid adeno-associated virus (AAV) identity testing platform through comprehensive intact mass analysis of full-length AAV capsid proteins, journal of proteome research, 2024</u></a></li> <br /> <li style="color: rgb(255,255,255);"><a href="https://www.isct-cytotherapy.org/article/S1465-3249(23)00950-7/fulltext" target="_blank" style="color: rgb(255,255,255);"><u>Equipment evaluation for process scalability and readiness for current Good Manufacturing Practices in cell therapy workflows, Cytotherapy, 2023</u></a></li> <br /> <li style="color: rgb(255,255,255);"><a style="color: rgb(255,255,255);" href="https://pubmed.ncbi.nlm.nih.gov/37419424/" target="_blank"><u>SP3-based host cell protein monitoring in AAV-based gene therapy products using LC-MS/MS. Eur J Pharm Biopharm. 2023</u></a></li> <br /> <li style="color: rgb(255,255,255);"><a style="color: rgb(255,255,255);" href="https://www.frontiersin.org/articles/10.3389/fbioe.2023.1223227/full" target="_blank"><u>Assessing the suitability of cell counting methods during different stages of a cell processing workflow using an ISO 20391-2 guided study design and analysis, Frontiers in Bioengineering and Biotechnology, 2023</u></a></li> <br /> <li style="color: rgb(255,255,255);"><a style="color: rgb(255,255,255);" href="https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(23)00159-6" target="_blank"><u>Universal ddPCR-based assay for the determination of lentivirus infectious titer and lenti-modified cell vector copy number, Molecular Therapy Methods & Clinical Development, 2023</u></a></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-141475143{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-141475143 { border-radius: px; } </style> </div> <div class="cmp-button aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--medium--3 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--xsmall--9 aem-GridColumn--offset--default--0 aem-GridColumn--default--2"> <div id="button-1455945311" class="btn-wrapper"> <a class=" btn btn-style-primary icon-placement-left " href="https://www.patheon.com/us/en/about-us/contact-us/capabilities.html?interest=Translational%20research%20of%20viral%20vectors" role="button" target="_self"> Contact us </a> </div> <style> #button-1455945311 .btn-style-quickLink { border-left: 6px solid #1E8AE7; } #button-1455945311 { padding-right:0px; padding-left:0px; } </style> </div> </div> </div> </div> <style type="text/css"> #well-1145081954 { border-radius: 0px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " style="background-color: #EBF2FA;background-position-x: center;background-position-y: center;border-color: #FFFFFF;" id="well-1867383483"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-762487079"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--phone--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0 aem-GridColumn--offset--medium--0 aem-GridColumn--phone--none aem-GridColumn--phone--6 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--6"> <div class="cmp-container-inner py-5 " id="container-1269639051"> <div class="aem-Grid aem-Grid--6 aem-Grid--small--12 aem-Grid--default--6 aem-Grid--xsmall--6 aem-Grid--phone--6 aem-Grid--medium--12 "> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--phone--6 aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--small--12 aem-GridColumn--default--6"> <div id="text-5cef59d297" class="cmp-text list-style-bullets"> <h4><b><a href="https://www.patheon.com/us/en/site-locations/san-diego-ca.html">Pharmaceutical services science and technology facility in San Diego, California, USA</a></b></h4> <h4> </h4> </div> </div> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--phone--none aem-GridColumn--xsmall--newline aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--small--12 aem-GridColumn--phone--2 aem-GridColumn--offset--phone--1 aem-GridColumn--default--6"> <div id="text-3aba13e9e1" class="cmp-text list-style-bullets"> <p>Our 32,000-square-foot facility is located at the heart of San Diego’s buzzing biotechnology hub. 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