CINXE.COM
Fast Forward | Journal of Pharmacology and Experimental Therapeutics
<!DOCTYPE html> <html lang="en" dir="ltr" xmlns="http://www.w3.org/1999/xhtml" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head prefix="og: http://ogp.me/ns# article: http://ogp.me/ns/article# book: http://ogp.me/ns/book#" > <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//securepubads.g.doubleclick.net" /> <link rel="dns-prefetch" href="//www.googletagmanager.com" /> <link rel="dns-prefetch" href="//cdn.foxycart.com" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <meta name="Generator" content="Drupal 7 (http://drupal.org)" /> <link rel="shortcut icon" href="https://jpet.aspetjournals.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <title>Fast Forward | Journal of Pharmacology and Experimental Therapeutics</title> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__D1jcFdgiF8kTmoGzrRvIZOTCaU7xTsfaSIzJbWyG_XU__lPqvo7iRyfvkf048Ftgved42W01OnfH1XeOrsDEkt5w__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <style type="text/css" media="all"> /* <![CDATA[ */ .user-menu-dropdown-logo>.menubar-nav>.nice-menu>.menuparent a:first-child{background:url('https://jpet.aspetjournals.org/sites/default/files/ASPET%20logo_Reverse%20White90x40.png') transparent no-repeat left top;padding-left:90px} /* ]]> */ </style> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__7CYEtfDxMu3CEBZ53TQrEfMpO7duR_XdIuTLye9W7Cc__6S17d7PTx8qxCI0N9xxJBsSirTg0BMKRBS_92GtE9fM__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <style type="text/css" media="all"> /* <![CDATA[ */ #sliding-popup.sliding-popup-bottom,#sliding-popup.sliding-popup-bottom .eu-cookie-withdraw-banner,.eu-cookie-withdraw-tab{background:#000}#sliding-popup.sliding-popup-bottom.eu-cookie-withdraw-wrapper{background:transparent}#sliding-popup .popup-content #popup-text h1,#sliding-popup .popup-content #popup-text h2,#sliding-popup .popup-content #popup-text h3,#sliding-popup .popup-content #popup-text p,.eu-cookie-compliance-secondary-button,.eu-cookie-withdraw-tab{color:#fff !important}.eu-cookie-withdraw-tab{border-color:#fff}.eu-cookie-compliance-more-button{color:#fff !important} /* ]]> */ </style> <!--[if lte IE 7]> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__ElJr3PIJEvw3qLXc1cnYiLj2G4KgDPSXFOfm6Phf8hw__JdWGm15cDWjsK6KrFlQVXQix9YgNeYysf22XZHj-Y-c__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <![endif]--> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__vP96nkAt3EeLU62QRdHXKZuS9tqQ1EMDJC_PSKd7hEk__lHjEjA8vesYocDHspzRjJD6B-seMDbxqo3imDh_XOlQ__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__jDlRKh8Fvd3KlEVLtvU4_FzoHoxonc2s6UFFVjnIlCI__uxnPlpZgPAME7jXPQp993gTkfTUD_4VyoV146ZZX2SI__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <!--[if (lt IE 9)&(!IEMobile)]> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__XH6bpcI0f2dImc-p674DLCZtWBGb-QwxJK1YexVGtno__vUceGprdo5nIhV6DH93X7fI3r8RcTJbChbas9TQXeW4__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <![endif]--> <!--[if gte IE 9]><!--> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__2WBMox6sOrN42ss5lCnH7WWVRdFdJCxtTKnQJYRwTE4__yqNvNYLvMpjy3ffuJrjjm9uW2i-Me1c23KLYuWHaqio__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <!--<![endif]--> <link type="text/css" rel="stylesheet" href="https://jpet.aspetjournals.org/sites/default/files/advagg_css/css__-wBOb6WPlq8lYeDW2qz-TM4xBszfZzP558rWu5JhXBs__nVqnNiVpXdwGxRID8fVcM68hjusTnXrbdC_uxL7rgdI__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.css" media="all" /> <script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__DdxPgqGimsdUot2QWNz_pGsHzqNGpx6RMCWHpL8YWkg__c6zfK6oHHbLpTal5PdQxeQI3xGoCM8IXWtEHwIZr560__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js"></script> <script type="text/javascript" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__gB-wkSPiN8YOlp_AcU2LDPsf7itEPIvmmeCriSfhuMs__RlAe7jNp19JhghQawVdSUKvmuGEYaMqpMdtnypdZ29A__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js"></script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i<a.length;i++)j=a[i],e(j)?g(j,0,l,0):w(j)?B(j):Object(j)===j&&h(j,l);else Object(a)===a&&h(a,l)},B.addPrefix=function(a,b){z[a]=b},B.addFilter=function(a){x.push(a)},B.errorTimeout=1e4,null==b.readyState&&b.addEventListener&&(b.readyState="loading",b.addEventListener("DOMContentLoaded",A=function(){b.removeEventListener("DOMContentLoaded",A,0),b.readyState="complete"},0)),a.yepnope=k(),a.yepnope.executeStack=h,a.yepnope.injectJs=function(a,c,d,e,i,j){var k=b.createElement("script"),l,o,e=e||B.errorTimeout;k.src=a;for(o in d)k.setAttribute(o,d[o]);c=j?h:c||f,k.onreadystatechange=k.onload=function(){!l&&g(k.readyState)&&(l=1,c(),k.onload=k.onreadystatechange=null)},m(function(){l||(l=1,c(1))},e),i?k.onload():n.parentNode.insertBefore(k,n)},a.yepnope.injectCss=function(a,c,d,e,g,i){var e=b.createElement("link"),j,c=i?h:c||f;e.href=a,e.rel="stylesheet",e.type="text/css";for(j in d)e.setAttribute(j,d[j]);g||(n.parentNode.insertBefore(e,n),m(c,0))}})(this,document); //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- yepnope({ test: Modernizr.matchmedia, nope: '/sites/all/libraries/media-match/media.match.min.js' }); //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; googletag.slots = googletag.slots || {}; //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- googletag.slots["jpet_skyscraper_160x600"] = googletag.defineSlot("/38096867/JPET_Skyscraper_160x600", [160, 600], "dfp-ad-jpet_skyscraper_160x600") .addService(googletag.pubads()); //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- googletag.slots["_leaderboard_728x90"] = googletag.defineSlot("/38096867/_Leaderboard_728x90", [728, 90], "dfp-ad-_leaderboard_728x90") .addService(googletag.pubads()); //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- document.createElement( "picture" ); //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- googletag.cmd.push(function() { googletag.pubads().enableAsyncRendering(); googletag.pubads().enableSingleRequest(); googletag.pubads().collapseEmptyDivs(); googletag.pubads().addEventListener("slotRenderEnded", function (event) { if (event.isEmpty) { var id = event.slot.getSlotElementId(); var x = document.getElementById(id); if (x.parentElement.classList.contains("dfp-tag-wrapper")) { x.parentElement.style.display = "none"; } } }); }); googletag.enableServices(); //--><!]]> </script> <script type="text/javascript" async="async"> <!--//--><![CDATA[//><!-- (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-TJLTMW'); //--><!]]> </script> <script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__GM3GJPR36rRIz0TRkjC5OQwrioSyN9aoYRivDhCO_AM__qAl84FcCv2jyN22yFGS5Oc85cjd9zKX6p_cFNLGhe-M__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js" async="async"></script> <script type="text/javascript" defer="defer" async="async" src="//cdn.foxycart.com/aspet.ecommerce.highwire.org/loader.js"></script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- jQuery.extend(Drupal.settings,{"basePath":"\/","pathPrefix":"","ajaxPageState":{"theme":"jcore_1","theme_token":"bejaUz16PTdFQuKbRITF6oz4cyPEvhWdFBIsQrwrp4M"},"colorbox":{"opacity":"0.85","current":"{current} of {total}","previous":"\u00ab Prev","next":"Next \u00bb","close":"Close","maxWidth":"98%","maxHeight":"98%","fixed":true,"mobiledetect":true,"mobiledevicewidth":"480px"},"user_uid":0,"customer_email":"","cartstack_siteid":"","foxycart_subdomain":"aspet.ecommerce.highwire.org","foxycart_always_show_cart_link":true,"hw_fc_cookie_domain":".aspetjournals.org","HighWireFoxycart":{"link_text":"Add to Cart (%short-price)","link_icon":""},"urlIsAjaxTrusted":{"\/content\/early\/recent":true},"nice_menus_options":{"delay":800,"speed":"fast"},"highwireResponsive":{"enquire_enabled":1,"breakpoints_configured":1,"breakpoints":{"zero":"all and (min-width: 0px)","xsmall":"all and (min-width: 380px)","narrow":"all and (min-width: 768px) and (min-device-width: 768px), (max-device-width: 800px) and (min-width: 768px) and (orientation:landscape)","normal":"all and (min-width: 980px) and (min-device-width: 980px), all and (max-device-width: 1024px) and (min-width: 1024px) and (orientation:landscape)","wide":"all and (min-width: 1220px)"}},"eu_cookie_compliance":{"popup_enabled":1,"popup_agreed_enabled":1,"popup_hide_agreed":0,"popup_clicking_confirmation":1,"popup_scrolling_confirmation":false,"popup_html_info":"\u003Cdiv\u003E\n \u003Cdiv class=\u0022popup-content info\u0022\u003E\n \u003Cdiv id=\u0022popup-text\u0022\u003E\n \u003Ch2\u003EWe use cookies on this site to enhance your user experience\u003C\/h2\u003E\u003Cp\u003EBy clicking any link on this page you are giving your consent for us to set cookies.\u003C\/p\u003E \u003C\/div\u003E\n \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n \u003Cbutton type=\u0022button\u0022 role=\u0022dialog\u0022 aria-labelledby=\u0022OK, I agree\u0022\n class=\u0022agree-button eu-cookie-compliance-default-button\u0022\u003EOK, I agree\u003C\/button\u003E\n \u003Cbutton type=\u0022button\u0022 role=\u0022dialog\u0022 aria-labelledby=\u0022No, give me more info\u0022\n class=\u0022find-more-button eu-cookie-compliance-more-button\u0022\u003ENo, give me more info\u003C\/button\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E","use_mobile_message":false,"mobile_popup_html_info":"\u003Cdiv\u003E\n \u003Cdiv class=\u0022popup-content info\u0022\u003E\n \u003Cdiv id=\u0022popup-text\u0022\u003E\n \u003C\/div\u003E\n \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n \u003Cbutton type=\u0022button\u0022 role=\u0022dialog\u0022 aria-labelledby=\u0022OK, I agree\u0022\n class=\u0022agree-button eu-cookie-compliance-default-button\u0022\u003EOK, I agree\u003C\/button\u003E\n \u003Cbutton type=\u0022button\u0022 role=\u0022dialog\u0022 aria-labelledby=\u0022No, give me more info\u0022\n class=\u0022find-more-button eu-cookie-compliance-more-button\u0022\u003ENo, give me more info\u003C\/button\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E","mobile_breakpoint":"768","popup_html_agreed":"\u003Cdiv\u003E\n \u003Cdiv class=\u0022popup-content agreed\u0022\u003E\n \u003Cdiv id=\u0022popup-text\u0022\u003E\n \u003Ch2\u003EThank you for accepting cookies\u003C\/h2\u003E\u003Cp\u003EYou can now hide this message or find out more about cookies.\u003C\/p\u003E \u003C\/div\u003E\n \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n \u003Cbutton type=\u0022button\u0022 class=\u0022hide-popup-button eu-cookie-compliance-hide-button\u0022\u003EHide\u003C\/button\u003E\n \u003Cbutton type=\u0022button\u0022 class=\u0022find-more-button eu-cookie-compliance-more-button-thank-you\u0022 \u003EMore info\u003C\/button\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E","popup_use_bare_css":false,"popup_height":"auto","popup_width":"100%","popup_delay":1000,"popup_link":"\/content\/our-use-cookies","popup_link_new_window":1,"popup_position":null,"popup_language":"en","store_consent":false,"better_support_for_screen_readers":0,"reload_page":0,"domain":"","popup_eu_only_js":0,"cookie_lifetime":"100","cookie_session":false,"disagree_do_not_show_popup":0,"method":"default","whitelisted_cookies":"","withdraw_markup":"\u003Cbutton type=\u0022button\u0022 class=\u0022eu-cookie-withdraw-tab\u0022\u003EPrivacy settings\u003C\/button\u003E\n\u003Cdiv class=\u0022eu-cookie-withdraw-banner\u0022\u003E\n \u003Cdiv class=\u0022popup-content info\u0022\u003E\n \u003Cdiv id=\u0022popup-text\u0022\u003E\n \u003Cp\u003E\u0026lt;h2\u0026gt;We use cookies on this site to enhance your user experience\u0026lt;\/h2\u0026gt;\u0026lt;p\u0026gt;You have given your consent for us to set cookies.\u0026lt;\/p\u0026gt;\u003C\/p\u003E\n \u003C\/div\u003E\n \u003Cdiv id=\u0022popup-buttons\u0022\u003E\n \u003Cbutton type=\u0022button\u0022 class=\u0022eu-cookie-withdraw-button\u0022\u003EWithdraw consent\u003C\/button\u003E\n \u003C\/div\u003E\n \u003C\/div\u003E\n\u003C\/div\u003E\n","withdraw_enabled":false},"color":{"logo":"https:\/\/jpet.aspetjournals.org\/sites\/default\/files\/JPET_700x104_0.png"},"omega":{"layouts":{"primary":"normal","order":["narrow","normal","wide"],"queries":{"narrow":"all and (min-width: 768px) and (min-device-width: 768px), (max-device-width: 800px) and (min-width: 768px) and (orientation:landscape)","normal":"all and (min-width: 980px) and (min-device-width: 980px), all and (max-device-width: 1024px) and (min-width: 1024px) and (orientation:landscape)","wide":"all and (min-width: 1220px)"}}}}); //--><!]]> </script> <!--[if lt IE 9]><script src="http://html5shiv.googlecode.com/svn/trunk/html5.js"></script><![endif]--> </head> <body class="html not-front not-logged-in page-content page-content-early page-content-early-recent context-content hw-default-jcode-jpet"> <div id="skip-link"> <a href="#main-content" class="element-invisible element-focusable">Skip to main content</a> </div> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TJLTMW" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="region region-page-top" id="region-page-top"> <div class="region-inner region-page-top-inner"> </div> </div> <div class="page clearfix page-box-shadows footer-borders panels-page panels-layout-jcore_2col" id="page"> <header id="section-header" class="section section-header"> <div id="zone-advertising-top-wrapper" class="zone-wrapper zone-advertising-top-wrapper clearfix"> <div id="zone-advertising-top" class="zone zone-advertising-top clearfix container-30"> <div class="grid-28 suffix-1 prefix-1 region region-ad-top" id="region-ad-top"> <div class="region-inner region-ad-top-inner"> <div class="block block-dfp rtecenter block--leaderboard-728x90 block-dfp-leaderboard-728x90 odd block-without-title" id="block-dfp-leaderboard-728x90"> <div class="block-inner clearfix"> <div class="content clearfix"> <div id="dfp-ad-_leaderboard_728x90-wrapper" class="dfp-tag-wrapper"><div class="slug">Advertisement</div> <div id="dfp-ad-_leaderboard_728x90" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-_leaderboard_728x90"); }); </script> </div> </div> </div> </div> </div> </div> </div> </div> </div><div id="zone-superheader-wrapper" class="zone-wrapper zone-superheader-wrapper clearfix mobile-only print-hidden"> <div id="zone-superheader" class="zone zone-superheader clearfix mobile-only print-hidden container-30"> <div class="grid-30 region region-superheader" id="region-superheader"> <div class="region-inner region-superheader-inner"> <div class="block block-panels-mini block-responsive-menu block-panels-mini-responsive-menu odd block-without-title" id="block-panels-mini-responsive-menu"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panel-1col clearfix" id="mini-panel-responsive_menu"> <div class="panel-panel panel-col"> <div><div id="unique-id3" class="highwire-responsive-toggle-group"><div class="panel-pane pane-panels-mini pane-responsive-menu-main-menu" > <h2 class="pane-title"><span class="icon-reorder"></span><span class="element-invisible">Main menu</span></h2> <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-responsive_menu_main_menu"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-menu-tree pane-main-menu" > <div class="pane-content"> <div class="menu-block-wrapper menu-block-ctools-main-menu-1 menu-name-main-menu parent-mlid-main-menu:0 menu-level-1"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-878" role="menuitem"><a href="/" class="" data-icon-position="" data-hide-link-title="0">Home</a></li> <li class="expanded menu-mlid-892" role="menuitem"><a href="/content/by/year" data-hide-link-title="0" class="" data-icon-position="">Articles</a><nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-893" role="menuitem"><a href="/content/current" data-hide-link-title="0" class="" data-icon-position="">Current Issue</a></li> <li class="leaf menu-mlid-896" role="menuitem"><a href="/content/early/by/section" data-hide-link-title="0" class="" data-icon-position="">Fast Forward</a></li> <li class="leaf menu-mlid-987" role="menuitem"><a href="/content/latest" data-hide-link-title="0" class="" data-icon-position="">Latest Articles</a></li> <li class="leaf menu-mlid-1371" role="menuitem"><a href="/content/special-sections" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Special Sections</a></li> <li class="last leaf menu-mlid-897" role="menuitem"><a href="/content/by/year" data-hide-link-title="0" class="" data-icon-position="">Archive</a></li> </ul></nav></li> <li class="expanded menu-mlid-932" role="menuitem"><a href="/content/ifora" data-hide-link-title="0" class="" data-icon-position="">Information</a><nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-934" role="menuitem"><a href="/content/ifora" data-hide-link-title="0" class="" data-icon-position="">Instructions to Authors</a></li> <li class="leaf menu-mlid-884" role="menuitem"><a href="https://jpet.msubmit.net/cgi-bin/main.plex" data-hide-link-title="0" class="" data-icon-position="">Submit a Manuscript</a></li> <li class="leaf menu-mlid-1231" role="menuitem"><a href="http://jpet.aspetjournals.org/content/jpet-faqs" data-hide-link-title="0" class="" data-icon-position="">FAQs</a></li> <li class="leaf menu-mlid-885" role="menuitem"><a href="http://aspetjournals.org/content/aspet-journals-subscriber-help-and-services" data-hide-link-title="0" class="" data-icon-position="">For Subscribers</a></li> <li class="leaf menu-mlid-936" role="menuitem"><a href="http://www.aspetjournals.org/content/terms" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Terms & Conditions of Use</a></li> <li class="last leaf menu-mlid-978" role="menuitem"><a href="https://marketplace.copyright.com/rs-ui-web/mp/search/journal/15210103" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Permissions</a></li> </ul></nav></li> <li class="leaf menu-mlid-937" role="menuitem"><a href="/content/edboard" data-hide-link-title="0" class="" data-icon-position="">Editorial Board</a></li> <li class="expanded menu-mlid-894" role="menuitem"><a href="/alerts" data-hide-link-title="0" class="" data-icon-position="">Alerts</a><nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-895" role="menuitem"><a href="/alerts" data-hide-link-title="0" class="" data-icon-position="">Alerts</a></li> <li class="last leaf menu-mlid-881" role="menuitem"><a href="/content/rss" data-hide-link-title="0" class="" data-icon-position="">RSS Feeds</a></li> </ul></nav></li> <li class="leaf menu-mlid-1173" role="menuitem"><a href="https://www.aspet.org/aspet/journals/journals-information/joint-virtual-issues/" data-hide-link-title="0" title="Virtual Issues" name="Virtual Issues" target="_blank" class="" data-icon-position="">Virtual Issues</a></li> <li class="leaf menu-mlid-979" role="menuitem"><a href="http://jpet.aspetjournals.org/feedback" data-hide-link-title="0" class="" data-icon-position="">Feedback</a></li> <li class="last leaf menu-mlid-1370" role="menuitem"><a href="https://jpet.msubmit.net/cgi-bin/main.plex" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Submit</a></li> </ul></nav></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-menu-tree pane-umbrella-menu" > <div class="pane-content"> <div class="menu-block-wrapper menu-block-ctools-umbrella-menu-1 menu-name-umbrella-menu parent-mlid-umbrella-menu:0 menu-level-1"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first last expanded menu-mlid-748" role="menuitem"><a href="/" class="" data-icon-position="" data-hide-link-title="0">Other Publications</a><nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-749" role="menuitem"><a href="http://dmd.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Drug Metabolism and Disposition</a></li> <li class="leaf menu-mlid-846" role="menuitem"><a href="http://jpet.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Journal of Pharmacology and Experimental Therapeutics</a></li> <li class="leaf menu-mlid-847" role="menuitem"><a href="http://molpharm.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Molecular Pharmacology</a></li> <li class="leaf menu-mlid-848" role="menuitem"><a href="http://pharmrev.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacological Reviews</a></li> <li class="leaf menu-mlid-948" role="menuitem"><a href="http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacology Research & Perspectives</a></li> <li class="last leaf menu-mlid-849" role="menuitem"><a href="https://aspet.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">ASPET</a></li> </ul></nav></li> </ul></nav></div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-pane pane-panels-mini pane-responsive-menu-user-menu" > <h2 class="pane-title"><span class="icon-gear"></span><span class="element-invisible">User menu</span></h2> <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-responsive_menu_user_menu"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-menu-tree pane-user-menu" > <div class="pane-content"> <div class="menu-block-wrapper menu-block-ctools-user-menu-1 menu-name-user-menu parent-mlid-user-menu:0 menu-level-1"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf menu-mlid-784" role="menuitem"><a href="/alerts" class="" data-icon-position="" data-hide-link-title="0">My alerts</a></li> <li class="leaf menu-mlid-785" role="menuitem"><a href="/user/login?destination=/content/early/recent" class="" data-icon-position="" data-hide-link-title="0">Log in</a></li> <li class="last leaf menu-mlid-1267" role="menuitem"><a href="/cart" class="link-icon-only link-icon"><span class="icon-shopping-cart"></span> <span class="title element-invisible">My Cart</span></a></li> </ul></nav></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-user-identities" > <div class="pane-content"> <div class="highwire-user-message" data-separator="|"><span class="highwire-user-institution" data-id-type="institution" data-identity="a%3A2%3A%7Bs%3A4%3A%22show%22%3Bi%3A1%3Bs%3A7%3A%22message%22%3Bs%3A50%3A%22Institution%3A%20%5Bidentity%3Ainstitutional_display_name%5D%22%3B%7D"></span></div> </div> </div> </div> </div> </div> </div> </div> <div class="panel-pane pane-panels-mini pane-responsive-menu-search" > <h2 class="pane-title"><span class="icon-search"></span><span class="element-invisible">Search</span></h2> <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-responsive_menu_search"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-seach-qsearch-nocontext" > <div class="pane-content"> <form class="highwire-quicksearch button-style-mini button-style-mini" action="/content/early/recent" method="post" id="highwire-search-qsearch-nocontext-form" accept-charset="UTF-8"><div><div class="form-item form-item-label-invisible form-type-textfield form-item-keywords"> <label class="element-invisible" for="quick_search_header_keywords_1090726696">Search for this keyword </label> <input placeholder="Search..." type="text" id="quick_search_header_keywords_1090726696" name="keywords" value="" size="60" maxlength="128" class="form-text" /> </div> <div class="button-wrapper button-mini"><span class="icon-search"></span><input data-icon-only="1" data-font-icon="icon-search" data-icon-position="after" type="submit" id="quick_search_header_submit_1666909640" name="op" value="Search" class="form-submit" /></div><input type="hidden" name="form_build_id" value="form-pMBMaO41JsjaZXzQolZ1X-FdPNtMbxCnd5sljIWy-QM" /> <input type="hidden" name="form_id" value="highwire_search_qsearch_nocontext_form" /> </div></form> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-2 highwire-responsive-advanced-search-link pane-menu-tree" > <div class="pane-content"> <ul class="menu"> <li><a href="/search" title="Advanced search">Advanced search</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div><div class="block block-panels-mini block-hw-small-logo block-panels-mini-hw-small-logo even block-without-title" id="block-panels-mini-hw-small-logo"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panel-1col clearfix" id="mini-panel-hw_small_logo"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-small-logo" > <div class="pane-content"> <a href="/" class="" data-icon-position="" data-hide-link-title="0"><img src="https://jpet.aspetjournals.org/sites/default/files/JPET_700x104.png" alt="Journal of Pharmacology and Experimental Therapeutics" title="Journal of Pharmacology and Experimental Therapeutics" /></a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div><div id="zone-user-wrapper" class="zone-wrapper zone-user-wrapper clearfix mobile-hidden print-hidden"> <div id="zone-user" class="zone zone-user clearfix equal-height-container mobile-hidden print-hidden container-30"> <div class="grid-10 region region-user-first equal-height-element" id="region-user-first"> <div class="region-inner region-user-first-inner"> <div class="block block-nice-menus block-2 block-nice-menus-2 odd block-without-title" id="block-nice-menus-2"> <div class="block-inner clearfix"> <div class="content clearfix user-menu-dropdown user-menu-dropdown-logo"> <nav class="menubar-nav"><ul class="nice-menu nice-menu-down nice-menu-umbrella-menu" id="nice-menu-2" role="menu"><li class="menu-748 menuparent menu-path-front first odd last" role="menuitem"><a href="/" class="" data-icon-position="" data-hide-link-title="0">Other Publications</a><ul role="menu"><li class="menu-749 menu-path-dmdaspetjournalsorg first odd " role="menuitem"><a href="http://dmd.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Drug Metabolism and Disposition</a></li> <li class="menu-846 menu-path-jpetaspetjournalsorg even " role="menuitem"><a href="http://jpet.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Journal of Pharmacology and Experimental Therapeutics</a></li> <li class="menu-847 menu-path-molpharmaspetjournalsorg odd " role="menuitem"><a href="http://molpharm.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Molecular Pharmacology</a></li> <li class="menu-848 menu-path-pharmrevaspetjournalsorg even " role="menuitem"><a href="http://pharmrev.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacological Reviews</a></li> <li class="menu-948 menu-path-onlinelibrarywileycom-journal-101002-issn2052-1707- odd " role="menuitem"><a href="http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacology Research & Perspectives</a></li> <li class="menu-849 menu-path-saspetorg even last" role="menuitem"><a href="https://aspet.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">ASPET</a></li> </ul></li> </ul></nav> </div> </div> </div> </div> </div><div class="grid-20 region region-user-second equal-height-element" id="region-user-second"> <div class="region-inner region-user-second-inner"> <div class="block block-panels-mini highwire-uid-string block-jnl-jpet-uid-strng block-panels-mini-jnl-jpet-uid-strng odd block-without-title" id="block-panels-mini-jnl-jpet-uid-strng"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_uid_strng"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-user-identities" > <div class="pane-content"> <div class="highwire-user-message" data-separator=" | "><span class="highwire-user-institution" data-id-type="institution" data-identity="a%3A2%3A%7Bs%3A4%3A%22show%22%3Bi%3A1%3Bs%3A7%3A%22message%22%3Bs%3A85%3A%22%3Cspan%20class%3D%22narrow-hidden%22%3EInstitution%3A%20%3C%2Fspan%3E%5Bidentity%3Ainstitutional_display_name%5D%22%3B%7D"></span></div> </div> </div> <div class="panel-pane pane-block pane-system-user-menu links inline pane-system" > <div class="pane-content"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf" role="menuitem"><a href="/alerts" class="" data-icon-position="" data-hide-link-title="0">My alerts</a></li> <li class="leaf" role="menuitem"><a href="/user/login?destination=/content/early/recent" class="" data-icon-position="" data-hide-link-title="0">Log in</a></li> <li class="last leaf" role="menuitem"><a href="/cart" class="link-icon-only link-icon"><span class="icon-shopping-cart"></span> <span class="title element-invisible">My Cart</span></a></li> </ul></nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="zone-branding" class="zone zone-branding clearfix mobile-hidden print-display-block container-30"> <div class="grid-19 prefix-1 region region-branding print-display-block" id="region-branding"> <div class="region-inner region-branding-inner"> <div class="branding-data clearfix"> <div class="logo-img"> <a href="/" rel="home" class="" data-icon-position="" data-hide-link-title="0"><img alt="Journal of Pharmacology and Experimental Therapeutics" src="https://jpet.aspetjournals.org/sites/default/files/JPET_700x104_0.png" /></a> </div> </div> </div> </div><div class="grid-9 suffix-1 region region-branding-second print-hidden" id="region-branding-second"> <div class="region-inner region-branding-second-inner"> <div class="block block-panels-mini block-jnl-jpet-search-box block-panels-mini-jnl-jpet-search-box odd block-without-title" id="block-panels-mini-jnl-jpet-search-box"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_search_box"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-seach-quicksearch no-margin-bottom" > <div class="pane-content"> <form class="highwire-quicksearch button-style-mini button-style-mini" action="/content/early/recent" method="post" id="highwire-search-quicksearch-form-0" accept-charset="UTF-8"><div><div class="form-item form-item-label-invisible form-type-textfield form-item-keywords"> <label class="element-invisible" for="search_rightsidebar_keywords_917097950">Search for this keyword </label> <input placeholder="search" type="text" id="search_rightsidebar_keywords_917097950" name="keywords" value="" size="60" maxlength="128" class="form-text" /> </div> <div class="button-wrapper button-mini"><span class="icon-search"></span><input data-icon-only="1" data-font-icon="icon-search" data-icon-position="after" type="submit" id="search_rightsidebar_submit_729726739" name="op" value="Search" class="form-submit" /></div><input type="hidden" name="form_build_id" value="form-7EGKXy4_Xp0F_Q24cbKoistZNX9Y0gc8vpimEKtxyeA" /> <input type="hidden" name="form_id" value="highwire_search_quicksearch_form_0" /> </div></form> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-3" > <div class="pane-content"> <p><a href="/search">Advanced Search</a></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="zone-menu" class="zone zone-menu clearfix mobile-hidden container-30"> <div class="grid-28 suffix-1 prefix-1 region region-menu main-menu-active-caret" id="region-menu"> <div class="region-inner region-menu-inner"> <div class="block block-nice-menus block-1 block-nice-menus-1 odd block-without-title" id="block-nice-menus-1"> <div class="block-inner clearfix"> <div class="content clearfix"> <nav class="menubar-nav"><ul class="nice-menu nice-menu-down nice-menu-main-menu" id="nice-menu-1" role="menu"><li class="menu-878 menu-path-front first odd " role="menuitem"><a href="/" class="" data-icon-position="" data-hide-link-title="0">Home</a></li> <li class="menu-892 menuparent menu-path-content-by-year even " role="menuitem"><a href="/content/by/year" data-hide-link-title="0" class="" data-icon-position="">Articles</a><ul role="menu"><li class="menu-893 menu-path-content-current first odd " role="menuitem"><a href="/content/current" data-hide-link-title="0" class="" data-icon-position="">Current Issue</a></li> <li class="menu-896 menu-path-content-early-by-section even " role="menuitem"><a href="/content/early/by/section" data-hide-link-title="0" class="" data-icon-position="">Fast Forward</a></li> <li class="menu-987 menu-path-content-latest odd " role="menuitem"><a href="/content/latest" data-hide-link-title="0" class="" data-icon-position="">Latest Articles</a></li> <li class="menu-1371 menu-path-node-150869 even " role="menuitem"><a href="/content/special-sections" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Special Sections</a></li> <li class="menu-897 menu-path-content-by-year odd last" role="menuitem"><a href="/content/by/year" data-hide-link-title="0" class="" data-icon-position="">Archive</a></li> </ul></li> <li class="menu-932 menuparent menu-path-node-1 odd " role="menuitem"><a href="/content/ifora" data-hide-link-title="0" class="" data-icon-position="">Information</a><ul role="menu"><li class="menu-934 menu-path-node-1 first odd " role="menuitem"><a href="/content/ifora" data-hide-link-title="0" class="" data-icon-position="">Instructions to Authors</a></li> <li class="menu-884 menu-path-sjpetmsubmitnet-cgi-bin-mainplex even " role="menuitem"><a href="https://jpet.msubmit.net/cgi-bin/main.plex" data-hide-link-title="0" class="" data-icon-position="">Submit a Manuscript</a></li> <li class="menu-1231 menu-path-jpetaspetjournalsorg-content-jpet-faqs odd " role="menuitem"><a href="http://jpet.aspetjournals.org/content/jpet-faqs" data-hide-link-title="0" class="" data-icon-position="">FAQs</a></li> <li class="menu-885 menu-path-aspetjournalsorg-content-aspet-journals-subscriber-help-and-services even " role="menuitem"><a href="http://aspetjournals.org/content/aspet-journals-subscriber-help-and-services" data-hide-link-title="0" class="" data-icon-position="">For Subscribers</a></li> <li class="menu-936 menu-path-aspetjournalsorg-content-terms odd " role="menuitem"><a href="http://www.aspetjournals.org/content/terms" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Terms & Conditions of Use</a></li> <li class="menu-978 menu-path-smarketplacecopyrightcom-rs-ui-web-mp-search-journal-15210103 even last" role="menuitem"><a href="https://marketplace.copyright.com/rs-ui-web/mp/search/journal/15210103" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Permissions</a></li> </ul></li> <li class="menu-937 menu-path-node-8 even " role="menuitem"><a href="/content/edboard" data-hide-link-title="0" class="" data-icon-position="">Editorial Board</a></li> <li class="menu-894 menuparent menu-path-alerts odd " role="menuitem"><a href="/alerts" data-hide-link-title="0" class="" data-icon-position="">Alerts</a><ul role="menu"><li class="menu-895 menu-path-alerts first odd " role="menuitem"><a href="/alerts" data-hide-link-title="0" class="" data-icon-position="">Alerts</a></li> <li class="menu-881 menu-path-node-6719 even last" role="menuitem"><a href="/content/rss" data-hide-link-title="0" class="" data-icon-position="">RSS Feeds</a></li> </ul></li> <li class="menu-1173 menu-path-saspetorg-aspet-journals-journals-information-joint-virtual-issues- even " role="menuitem"><a href="https://www.aspet.org/aspet/journals/journals-information/joint-virtual-issues/" data-hide-link-title="0" title="Virtual Issues" name="Virtual Issues" target="_blank" class="" data-icon-position="">Virtual Issues</a></li> <li class="menu-979 menu-path-jpetaspetjournalsorg-feedback odd " role="menuitem"><a href="http://jpet.aspetjournals.org/feedback" data-hide-link-title="0" class="" data-icon-position="">Feedback</a></li> <li class="menu-1370 menu-path-sjpetmsubmitnet-cgi-bin-mainplex even last" role="menuitem"><a href="https://jpet.msubmit.net/cgi-bin/main.plex" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Submit</a></li> </ul></nav> </div> </div> </div><div class="block block-menu text-right block-menu-social-media block-menu-menu-social-media even block-without-title" id="block-menu-menu-social-media"> <div class="block-inner clearfix"> <div class="content clearfix"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf" role="menuitem"><a href="https://www.facebook.com/jpetaspetjournal/" target="_blank" class="link-icon-only link-icon"><span class="icon-facebook-sign icon-2x"></span> <span class="title element-invisible">Visit jpet on Facebook</span></a></li> <li class="leaf" role="menuitem"><a href="https://twitter.com/JPET_Journal" target="_blank" class="link-icon-only link-icon"><span class="hw-icon-x-twitter"></span> <span class="title element-invisible">Follow jpet on Twitter</span></a></li> <li class="last leaf" role="menuitem"><a href="https://www.linkedin.com/groups/3320218" target="_blank" class="link-icon-only link-icon"><span class="icon-linkedin-sign icon-2x"></span> <span class="title element-invisible">Follow jpet on LinkedIn</span></a></li> </ul></nav> </div> </div> </div> </div> </div> </div> <div id="zone-header" class="zone zone-header clearfix container-30"> </div> </header> <section id="section-content" class="section section-content"> <div id="zone-content" class="zone zone-content clearfix container-30"> <div class="grid-28 suffix-1 prefix-1 region region-content" id="region-content"> <div class="region-inner region-content-inner"> <a id="main-content"></a> <div class="block block-system block-main block-system-main odd block-without-title" id="block-system-main"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panels-960-layout jcore-2col-layout" > <div class="panel-row-wrapper panel-row-first clearfix"> <div class="top-wrapper"> <div class="panel-panel panel-region-top"> <div class="inside"><div class="panel-pane pane-page-title" > <div class="pane-content"> <h1 id="page-title">Fast Forward</h1> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-snippet pane-aspet-pap-information" > <div class="pane-content"> <div class="snippet aspet-pap-information" id="aspet-pap-information"> <div class="snippet-content"> <p><em>JPET Fast Forward</em> contains papers in manuscript form that have been accepted and published in <em>JPET</em> but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).</p> </div> </div> </div> </div> </div> </div> </div> </div> <!-- /.panel-row-wrapper --> <div class="panel-row-wrapper clearfix"> <div class="main-content-wrapper grid-17 suffix-1 alpha"> <div class="panel-panel panel-region-content"> <div class="inside"><div class="panel-pane pane-highwire-pap" > <div class="pane-content"> <div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">November 04, 2024</h3><div class="highwire-list"><ul id="november-04-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156697" data-node-nid="156697" id="node-156697--21188856452" data-pisa="jpet;jpet.124.002347v1" data-pisa-master="jpet;jpet.124.002347" data-apath="/jpet/early/2024/11/04/jpet.124.002347.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002347" data-atom-uri="/jpet/early/2024/11/04/jpet.124.002347.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/11/04/jpet.124.002347" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Preclinical Evaluation of MK-8189: A Novel Phosphodiesterase 10A Inhibitor for the Treatment of Schizophrenia</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Sean Smith</span>, <span class="highwire-citation-author" data-delta="1">Dawn Toolan</span>, <span class="highwire-citation-author" data-delta="2">Monika Kandebo</span>, <span class="highwire-citation-author" data-delta="3">Joshua Vardigan</span>, <span class="highwire-citation-author" data-delta="4">Izzat Raheem</span>, <span class="highwire-citation-author" data-delta="5">Mark E Layton</span>, <span class="highwire-citation-author" data-delta="6">Jeffrey C Kern</span>, <span class="highwire-citation-author" data-delta="7">Christopher Cox</span>, <span class="highwire-citation-author" data-delta="8">Liza Gantert</span>, <span class="highwire-citation-author" data-delta="9">Kerry Riffel</span>, <span class="highwire-citation-author" data-delta="10">Eric Hostetler</span> and <span class="highwire-citation-author" data-delta="11">Jason M. Uslaner</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">November 4, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002347; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002347 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/11/04/jpet.124.002347.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">October 23, 2024</h3><div class="highwire-list"><ul id="october-23-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156694" data-node-nid="156694" id="node-156694--21282539859" data-pisa="jpet;jpet.124.002334v1" data-pisa-master="jpet;jpet.124.002334" data-apath="/jpet/early/2024/10/23/jpet.124.002334.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002334" data-atom-uri="/jpet/early/2024/10/23/jpet.124.002334.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/23/jpet.124.002334" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Clinical Development of the GluN2B-selective NMDA Receptor Inhibitor NP10679 for the Treatment of Neurologic Deficit after Subarachnoid Hemorrhage</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Haichen Wang</span>, <span class="highwire-citation-author" data-delta="1">Raymond J Dingledine</span>, <span class="highwire-citation-author" data-delta="2">Scott J. Myers</span>, <span class="highwire-citation-author" data-delta="3">Stephen F. Traynelis</span>, <span class="highwire-citation-author" data-delta="4">Chuan Fang</span>, <span class="highwire-citation-author" data-delta="5">Yanli Tan</span>, <span class="highwire-citation-author" data-delta="6">George W Koszalka</span> and <span class="highwire-citation-author" data-delta="7">Daniel T. Laskowitz</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 23, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002334; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002334 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/23/jpet.124.002334.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">October 08, 2024</h3><div class="highwire-list"><ul id="october-08-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156502" data-node-nid="156502" id="node-156502--2657826265" data-pisa="jpet;jpet.124.002104v1" data-pisa-master="jpet;jpet.124.002104" data-apath="/jpet/early/2024/10/08/jpet.124.002104.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002104" data-atom-uri="/jpet/early/2024/10/08/jpet.124.002104.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/08/jpet.124.002104" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Pharmacological effects of small molecule BCR-ABL tyrosine kinase inhibitors on platelet <strong>function</strong></strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Yiheng Zhang</span>, <span class="highwire-citation-author" data-delta="1">Chih-Jen Yang</span>, <span class="highwire-citation-author" data-delta="2">Alexander R. Melrose</span>, <span class="highwire-citation-author" data-delta="3">Jiaqing Pang</span>, <span class="highwire-citation-author" data-delta="4">Kirrali Schofield</span>, <span class="highwire-citation-author" data-delta="5">Serena D. Song</span>, <span class="highwire-citation-author" data-delta="6">Iván Parra-Izquierdo</span>, <span class="highwire-citation-author" data-delta="7">Tony J. Zheng</span>, <span class="highwire-citation-author" data-delta="8">Joseph P. Lyssikatos</span>, <span class="highwire-citation-author" data-delta="9">Stefan D. Gross</span>, <span class="highwire-citation-author" data-delta="10">Joseph J. Shatzel</span>, <span class="highwire-citation-author" data-delta="11">Owen J. T. McCarty</span> and <span class="highwire-citation-author" data-delta="12">Joseph E. Aslan</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 8, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002104; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002104 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/08/jpet.124.002104.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156499" data-node-nid="156499" id="node-156499--2989368365" data-pisa="jpet;jpet.124.002238v1" data-pisa-master="jpet;jpet.124.002238" data-apath="/jpet/early/2024/10/08/jpet.124.002238.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002238" data-atom-uri="/jpet/early/2024/10/08/jpet.124.002238.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/08/jpet.124.002238" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>The protective effect of irisin against hemorrhagic injury is mediated by PI3K and p38 pathways in hemorrhage/resuscitation.</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Huai Wen</span>, <span class="highwire-citation-author" data-delta="1">Naohiro Yano</span>, <span class="highwire-citation-author" data-delta="2">Thomas Zhao</span>, <span class="highwire-citation-author" data-delta="3">Lei Wei</span> and <span class="highwire-citation-author" data-delta="4">Ting C Zhao</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 8, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002238; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002238 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/08/jpet.124.002238.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156494" data-node-nid="156494" id="node-156494--21936267820" data-pisa="jpet;jpet.124.002424v1" data-pisa-master="jpet;jpet.124.002424" data-apath="/jpet/early/2024/10/08/jpet.124.002424.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002424" data-atom-uri="/jpet/early/2024/10/08/jpet.124.002424.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/08/jpet.124.002424" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Metformin in Overcoming Enzalutamide Resistance in Castration-Resistant Prostate Cancer</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Kendall Simpson</span>, <span class="highwire-citation-author" data-delta="1">Derek B. Allison</span>, <span class="highwire-citation-author" data-delta="2">Daheng He</span>, <span class="highwire-citation-author" data-delta="3">Jinpeng Liu</span>, <span class="highwire-citation-author" data-delta="4">Chi Wang</span> and <span class="highwire-citation-author" data-delta="5">Xiaoqi Liu</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 8, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002424; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002424 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/08/jpet.124.002424.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156495" data-node-nid="156495" id="node-156495--2118329745" data-pisa="jpet;jpet.124.002254v1" data-pisa-master="jpet;jpet.124.002254" data-apath="/jpet/early/2024/10/08/jpet.124.002254.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002254" data-atom-uri="/jpet/early/2024/10/08/jpet.124.002254.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/08/jpet.124.002254" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Eugenio Antonio Carrera Silva</span>, <span class="highwire-citation-author" data-delta="1">Jorge Correale</span>, <span class="highwire-citation-author" data-delta="2">Carla Rothlin</span> and <span class="highwire-citation-author" data-delta="3">Juan Manuel Ortiz Wilczyñski</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 8, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002254; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002254 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/08/jpet.124.002254.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156497" data-node-nid="156497" id="node-156497--22059554181" data-pisa="jpet;jpet.124.002207v1" data-pisa-master="jpet;jpet.124.002207" data-apath="/jpet/early/2024/10/08/jpet.124.002207.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002207" data-atom-uri="/jpet/early/2024/10/08/jpet.124.002207.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/10/08/jpet.124.002207" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">The protective effect of Amitriptyline on experimental colitis through inhibiting TLR4/MD2 signaling pathway</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Chengcheng Zeng</span>, <span class="highwire-citation-author" data-delta="1">Qingqing Zhu</span>, <span class="highwire-citation-author" data-delta="2">Wu Peng</span>, <span class="highwire-citation-author" data-delta="3">Chen Huang</span>, <span class="highwire-citation-author" data-delta="4">Huiting Chen</span>, <span class="highwire-citation-author" data-delta="5">Hongli Huang</span>, <span class="highwire-citation-author" data-delta="6">Yongjian Zhou</span> and <span class="highwire-citation-author" data-delta="7">Chong Zhao</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">October 8, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002207; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002207 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/10/08/jpet.124.002207.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">September 20, 2024</h3><div class="highwire-list"><ul id="september-20-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156482" data-node-nid="156482" id="node-156482--256844549" data-pisa="jpet;jpet.124.002252v1" data-pisa-master="jpet;jpet.124.002252" data-apath="/jpet/early/2024/09/20/jpet.124.002252.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002252" data-atom-uri="/jpet/early/2024/09/20/jpet.124.002252.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/09/20/jpet.124.002252" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Efficacy of Fluoxetine and (<em>R,S)</em> Ketamine in Attenuating Conditioned Fear Behaviors in Male Mice</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Megan Wells</span>, <span class="highwire-citation-author" data-delta="1">Jan Hoffmann</span>, <span class="highwire-citation-author" data-delta="2">Autumn Stage</span>, <span class="highwire-citation-author" data-delta="3">Isabella Enger</span>, <span class="highwire-citation-author" data-delta="4">Jayme Pomper</span>, <span class="highwire-citation-author" data-delta="5">Lily Briggs</span> and <span class="highwire-citation-author" data-delta="6">Amber LaCrosse</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">September 20, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002252; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002252 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/09/20/jpet.124.002252.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156483" data-node-nid="156483" id="node-156483--21137732460" data-pisa="jpet;jpet.124.002356v1" data-pisa-master="jpet;jpet.124.002356" data-apath="/jpet/early/2024/09/20/jpet.124.002356.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002356" data-atom-uri="/jpet/early/2024/09/20/jpet.124.002356.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/09/20/jpet.124.002356" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Contrasting the Reinforcing Effects of the Novel Dopamine Transport Inhibitors JJC8-088 and JJC8-091 in Monkeys: Potential Translation to Medication Assisted Treatment </strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Mia I. Allen</span>, <span class="highwire-citation-author" data-delta="1">Omeed Rahimi</span>, <span class="highwire-citation-author" data-delta="2">Bernard N. Johnson</span>, <span class="highwire-citation-author" data-delta="3">Jianjing Cao</span>, <span class="highwire-citation-author" data-delta="4">Amy Hauck Newman</span> and <span class="highwire-citation-author" data-delta="5">Michael A Nader</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">September 20, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002356; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002356 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/09/20/jpet.124.002356.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">September 16, 2024</h3><div class="highwire-list"><ul id="september-16-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156468" data-node-nid="156468" id="node-156468--2456304042" data-pisa="jpet;jpet.124.002138v1" data-pisa-master="jpet;jpet.124.002138" data-apath="/jpet/early/2024/09/16/jpet.124.002138.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002138" data-atom-uri="/jpet/early/2024/09/16/jpet.124.002138.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/09/16/jpet.124.002138" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Identification of pyrimidine structure-based compounds as allosteric ligands of the dopamine transporter as therapeutic agents for NeuroHIV</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ana Catya Jimenez-Torres</span>, <span class="highwire-citation-author" data-delta="1">Jamison A Hastie</span>, <span class="highwire-citation-author" data-delta="2">Sarah E Davis</span>, <span class="highwire-citation-author" data-delta="3">Katherine D Porter</span>, <span class="highwire-citation-author" data-delta="4">Bin Lei</span>, <span class="highwire-citation-author" data-delta="5">Omar Moukha-Chafiq</span>, <span class="highwire-citation-author" data-delta="6">Sixue Zhang</span>, <span class="highwire-citation-author" data-delta="7">Theresa H Nguyen</span>, <span class="highwire-citation-author" data-delta="8">Subramaniam Ananthan</span>, <span class="highwire-citation-author" data-delta="9">Corinne E Augelli-Szafran</span> and <span class="highwire-citation-author" data-delta="10">Jun Zhu</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">September 16, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002138; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002138 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/09/16/jpet.124.002138.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156464" data-node-nid="156464" id="node-156464--21561792840" data-pisa="jpet;jpet.124.002237v1" data-pisa-master="jpet;jpet.124.002237" data-apath="/jpet/early/2024/09/16/jpet.124.002237.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002237" data-atom-uri="/jpet/early/2024/09/16/jpet.124.002237.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/09/16/jpet.124.002237" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Claire E Miller</span> and <span class="highwire-citation-author" data-delta="1">Phillip R Zoladz</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">September 16, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002237; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002237 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/09/16/jpet.124.002237.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156461" data-node-nid="156461" id="node-156461--21235719305" data-pisa="jpet;jpet.124.002281v1" data-pisa-master="jpet;jpet.124.002281" data-apath="/jpet/early/2024/09/16/jpet.124.002281.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002281" data-atom-uri="/jpet/early/2024/09/16/jpet.124.002281.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/09/16/jpet.124.002281" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">First-in-Class Mitogen-Activated Protein Kinase p38α: MAPK-Activated Protein Kinase-2 (MK2) Dual Signal Modulator with Anti-inflammatory and Endothelial-stabilizing Properties</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Mohan E Tulapurkar</span>, <span class="highwire-citation-author" data-delta="1">Kari Ann Shirey</span>, <span class="highwire-citation-author" data-delta="2">Katerina N. Lugkey</span>, <span class="highwire-citation-author" data-delta="3">Wendy Luo</span>, <span class="highwire-citation-author" data-delta="4">Ritu Lal</span>, <span class="highwire-citation-author" data-delta="5">Adam Galan</span>, <span class="highwire-citation-author" data-delta="6">Omar Mahmoud</span>, <span class="highwire-citation-author" data-delta="7">Nathaniel McClean</span>, <span class="highwire-citation-author" data-delta="8">Kiruphagaran Thangaraju</span>, <span class="highwire-citation-author" data-delta="9">Daniel Cericola</span>, <span class="highwire-citation-author" data-delta="10">Daniel Lewis</span>, <span class="highwire-citation-author" data-delta="11">William A. Murphy</span>, <span class="highwire-citation-author" data-delta="12">Steven Fletcher</span>, <span class="highwire-citation-author" data-delta="13">Alexander D. MacKerell</span>, <span class="highwire-citation-author" data-delta="14">Stefanie N. Vogel</span>, <span class="highwire-citation-author" data-delta="15">Paul Shapiro</span> and <span class="highwire-citation-author" data-delta="16">Jeffrey D Hasday</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">September 16, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002281; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002281 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/09/16/jpet.124.002281.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">August 23, 2024</h3><div class="highwire-list"><ul id="august-23-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156329" data-node-nid="156329" id="node-156329--21874873330" data-pisa="jpet;jpet.124.002154v1" data-pisa-master="jpet;jpet.124.002154" data-apath="/jpet/early/2024/08/23/jpet.124.002154.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002154" data-atom-uri="/jpet/early/2024/08/23/jpet.124.002154.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/08/23/jpet.124.002154" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS‐CoV‐2 Spike protein subunit 1 - induced acute lung injury in mice</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Pavel A Solopov</span>, <span class="highwire-citation-author" data-delta="1">Ruben Manuel Luciano Colunga Biancatelli</span>, <span class="highwire-citation-author" data-delta="2">Tierney Day</span>, <span class="highwire-citation-author" data-delta="3">Betsy Gregory</span>, <span class="highwire-citation-author" data-delta="4">Elizabeth R Sharlow</span>, <span class="highwire-citation-author" data-delta="5">John S. Lazo</span> and <span class="highwire-citation-author" data-delta="6">John D Catravas</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">August 23, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002154; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002154 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/08/23/jpet.124.002154.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156331" data-node-nid="156331" id="node-156331--2405761190" data-pisa="jpet;jpet.124.002222v1" data-pisa-master="jpet;jpet.124.002222" data-apath="/jpet/early/2024/08/23/jpet.124.002222.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002222" data-atom-uri="/jpet/early/2024/08/23/jpet.124.002222.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/08/23/jpet.124.002222" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Significance of Nitric Oxide Derived from the </strong><strong>Nitric Oxide Synthases System in Cardiovascular </strong><strong>Inter-Organ Cross-Talk</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Masato Tsutsui</span> and <span class="highwire-citation-author" data-delta="1">Kazuhiro Yatera</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">August 23, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002222; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002222 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/08/23/jpet.124.002222.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">August 21, 2024</h3><div class="highwire-list"><ul id="august-21-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156319" data-node-nid="156319" id="node-156319--21478565634" data-pisa="jpet;jpet.124.002184v1" data-pisa-master="jpet;jpet.124.002184" data-apath="/jpet/early/2024/08/21/jpet.124.002184.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002184" data-atom-uri="/jpet/early/2024/08/21/jpet.124.002184.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/08/21/jpet.124.002184" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Drug-induced long QT syndrome: Concept and non-clinical models for predicting the onset of drug-induced torsade de pointes in patients in compliance with ICH E14/S7B guidance</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Atsushi Sugiyama</span>, <span class="highwire-citation-author" data-delta="1">Ai Goto</span>, <span class="highwire-citation-author" data-delta="2">Hiroko Izumi-Nakaseko</span>, <span class="highwire-citation-author" data-delta="3">Yoshinori Takei</span>, <span class="highwire-citation-author" data-delta="4">Akira Takahara</span> and <span class="highwire-citation-author" data-delta="5">Ryuichi Kambayashi</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">August 21, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002184; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002184 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/08/21/jpet.124.002184.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156320" data-node-nid="156320" id="node-156320--22026347268" data-pisa="jpet;jpet.124.002282v1" data-pisa-master="jpet;jpet.124.002282" data-apath="/jpet/early/2024/08/21/jpet.124.002282.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002282" data-atom-uri="/jpet/early/2024/08/21/jpet.124.002282.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/08/21/jpet.124.002282" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Mitigation of cisplatin-induced acute kidney injury through oral administration of FAAH Inhibitor PF-04457845</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Chaoling Chen</span>, <span class="highwire-citation-author" data-delta="1">Weili Wang</span>, <span class="highwire-citation-author" data-delta="2">Justin L. Poklis</span>, <span class="highwire-citation-author" data-delta="3">Pin-Lan Li</span>, <span class="highwire-citation-author" data-delta="4">Aron H. Lichtman</span>, <span class="highwire-citation-author" data-delta="5">David A. Gewirtz</span> and <span class="highwire-citation-author" data-delta="6">Ningjun Li</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">August 21, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002282; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002282 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/08/21/jpet.124.002282.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156321" data-node-nid="156321" id="node-156321--2969364191" data-pisa="jpet;jpet.124.002273v1" data-pisa-master="jpet;jpet.124.002273" data-apath="/jpet/early/2024/08/21/jpet.124.002273.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002273" data-atom-uri="/jpet/early/2024/08/21/jpet.124.002273.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/08/21/jpet.124.002273" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Inhibition of TTX-S Na<sup>+</sup> currents by a novel blocker QLS-278 for antinociception</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Min Su</span>, <span class="highwire-citation-author" data-delta="1">Xiang-shuo Ou-yang</span>, <span class="highwire-citation-author" data-delta="2">Ping Zhou</span>, <span class="highwire-citation-author" data-delta="3">Li-ying Dong</span>, <span class="highwire-citation-author" data-delta="4">Li-ming Shao</span>, <span class="highwire-citation-author" data-delta="5">Ke-Wei Wang</span> and <span class="highwire-citation-author" data-delta="6">Ya-ni Liu</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">August 21, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002273; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002273 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/08/21/jpet.124.002273.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">July 19, 2024</h3><div class="highwire-list"><ul id="july-19-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156227" data-node-nid="156227" id="node-156227--2478606173" data-pisa="jpet;jpet.124.002223v1" data-pisa-master="jpet;jpet.124.002223" data-apath="/jpet/early/2024/07/19/jpet.124.002223.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002223" data-atom-uri="/jpet/early/2024/07/19/jpet.124.002223.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/07/19/jpet.124.002223" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong><strong>OKN-007 is an Effective Anticancer Therapeutic Agent Targeting Inflammatory and Immune Metabolism Pathways in Endometrial Cancer.</strong></strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Sugantha Priya Elayapillai</span>, <span class="highwire-citation-author" data-delta="1">Anjalika Gandhi</span>, <span class="highwire-citation-author" data-delta="2">Samrita Dogra</span>, <span class="highwire-citation-author" data-delta="3">Debra Saunders</span>, <span class="highwire-citation-author" data-delta="4">Nataliya Smith</span>, <span class="highwire-citation-author" data-delta="5">Cole Hladik</span>, <span class="highwire-citation-author" data-delta="6">Rheal A. Towner</span>, <span class="highwire-citation-author" data-delta="7">Katherine M. Moxley</span> and <span class="highwire-citation-author" data-delta="8">Bethany N. Hannafon</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">July 19, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002223; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002223 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/07/19/jpet.124.002223.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156221" data-node-nid="156221" id="node-156221--21169479380" data-pisa="jpet;jpet.124.002086v1" data-pisa-master="jpet;jpet.124.002086" data-apath="/jpet/early/2024/07/19/jpet.124.002086.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002086" data-atom-uri="/jpet/early/2024/07/19/jpet.124.002086.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/07/19/jpet.124.002086" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Interrogating a Compound Library in Search of an Inhibitor for TREM-like Transcript-1 to Fibrinogen Binding</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Andrea Acsiniuc</span>, <span class="highwire-citation-author" data-delta="1">Barbara Manfredi</span>, <span class="highwire-citation-author" data-delta="2">Javier Menédez-Pérez</span>, <span class="highwire-citation-author" data-delta="3">Siobhan Branfield</span> and <span class="highwire-citation-author" data-delta="4">A Valance Washington</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">July 19, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002086; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002086 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/07/19/jpet.124.002086.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156222" data-node-nid="156222" id="node-156222--21928010216" data-pisa="jpet;jpet.124.002203v1" data-pisa-master="jpet;jpet.124.002203" data-apath="/jpet/early/2024/07/19/jpet.124.002203.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002203" data-atom-uri="/jpet/early/2024/07/19/jpet.124.002203.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/07/19/jpet.124.002203" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Mechanisms and management of thrombosis in cancer: focus on gastrointestinal malignancies</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Simone Monegatti</span>, <span class="highwire-citation-author" data-delta="1">Nicola Martinelli</span>, <span class="highwire-citation-author" data-delta="2">Simonetta Friso</span>, <span class="highwire-citation-author" data-delta="3">Henri MH Spronk</span> and <span class="highwire-citation-author" data-delta="4">Hugo ten Cate</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">July 19, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002203; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002203 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/07/19/jpet.124.002203.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">July 02, 2024</h3><div class="highwire-list"><ul id="july-02-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156129" data-node-nid="156129" id="node-156129--21234388163" data-pisa="jpet;jpet.124.002171v1" data-pisa-master="jpet;jpet.124.002171" data-apath="/jpet/early/2024/07/02/jpet.124.002171.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002171" data-atom-uri="/jpet/early/2024/07/02/jpet.124.002171.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/07/02/jpet.124.002171" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Formoterol alters chemokine expression and ameliorates pain behaviors after moderate spinal cord injury in female mice</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ingrid L Peterson</span>, <span class="highwire-citation-author" data-delta="1">Natalie E Scholpa</span>, <span class="highwire-citation-author" data-delta="2">Kiara J Bachtle</span>, <span class="highwire-citation-author" data-delta="3">Jennifer B Frye</span>, <span class="highwire-citation-author" data-delta="4">Sanna H Loppi</span>, <span class="highwire-citation-author" data-delta="5">Austin D Thompson</span>, <span class="highwire-citation-author" data-delta="6">Kristian Doyle</span>, <span class="highwire-citation-author" data-delta="7">Tally Marie Largent-Milnes</span> and <span class="highwire-citation-author" data-delta="8">Rick G. Schnellmann</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">July 2, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002171; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002171 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/07/02/jpet.124.002171.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">June 27, 2024</h3><div class="highwire-list"><ul id="june-27-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156127" data-node-nid="156127" id="node-156127--21214878139" data-pisa="jpet;jpet.124.002240v1" data-pisa-master="jpet;jpet.124.002240" data-apath="/jpet/early/2024/06/27/jpet.124.002240.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002240" data-atom-uri="/jpet/early/2024/06/27/jpet.124.002240.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/27/jpet.124.002240" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">NOSH-aspirin (NBS-1120) inhibits estrogen receptor negative breast cancer <em>in vitro</em> and i<em>n vivo</em> by modulating redox-sensitive signaling pathways</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Mitali Chattopadhyay</span>, <span class="highwire-citation-author" data-delta="1">Niharika Nath</span>, <span class="highwire-citation-author" data-delta="2">Ravinder Kodela</span>, <span class="highwire-citation-author" data-delta="3">Shalaka Metkar</span>, <span class="highwire-citation-author" data-delta="4">Sarin A. Soyemi</span> and <span class="highwire-citation-author" data-delta="5">Khosrow Kashfi</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 27, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002240; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002240 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/27/jpet.124.002240.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156122" data-node-nid="156122" id="node-156122--21326694934" data-pisa="jpet;jpet.124.002199v1" data-pisa-master="jpet;jpet.124.002199" data-apath="/jpet/early/2024/06/27/jpet.124.002199.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002199" data-atom-uri="/jpet/early/2024/06/27/jpet.124.002199.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/27/jpet.124.002199" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Quantification </strong><strong>of </strong><strong>Cinpanemab (BIIB054) Binding to </strong><strong>α-</strong><strong>Synuclein in Cerebrospinal Fluid of Phase 1 Single Ascending Dose Samples </strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">YuTing Liu</span>, <span class="highwire-citation-author" data-delta="1">Minhua Yang</span>, <span class="highwire-citation-author" data-delta="2">Kyle Fraser</span>, <span class="highwire-citation-author" data-delta="3">Danielle Graham</span>, <span class="highwire-citation-author" data-delta="4">Paul H. Weinreb</span>, <span class="highwire-citation-author" data-delta="5">Andreas Weihofen</span>, <span class="highwire-citation-author" data-delta="6">Warren D. Hirst</span>, <span class="highwire-citation-author" data-delta="7">Jesse M. Cedarbaum</span> and <span class="highwire-citation-author" data-delta="8">Blake Pepinsky</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 27, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002199; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002199 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/27/jpet.124.002199.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node156125" data-node-nid="156125" id="node-156125--2605165803" data-pisa="jpet;jpet.123.001874v1" data-pisa-master="jpet;jpet.123.001874" data-apath="/jpet/early/2024/06/27/jpet.123.001874.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.123.001874" data-atom-uri="/jpet/early/2024/06/27/jpet.123.001874.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/27/jpet.123.001874" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>The elucidation of species-specific receptor pharmacology: a case study using subtype selective <em>para</em>- and <em>meta</em>-carborane estrogen receptor agonists</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Adeoluwa A. Adeluola</span>, <span class="highwire-citation-author" data-delta="1">Hanna S. Radomska</span>, <span class="highwire-citation-author" data-delta="2">Tyler A. Wilson</span>, <span class="highwire-citation-author" data-delta="3">Samuel K. Kulp</span>, <span class="highwire-citation-author" data-delta="4">Alyssa Kabat</span>, <span class="highwire-citation-author" data-delta="5">Timothy H. Helms</span>, <span class="highwire-citation-author" data-delta="6">Abigail K. Mayo</span>, <span class="highwire-citation-author" data-delta="7">Emma J. Montgomery</span>, <span class="highwire-citation-author" data-delta="8">Justin Thomas</span>, <span class="highwire-citation-author" data-delta="9">Lynn M. Marcho</span>, <span class="highwire-citation-author" data-delta="10">Travis Costa</span>, <span class="highwire-citation-author" data-delta="11">Mayu Fukuda</span>, <span class="highwire-citation-author" data-delta="12">Diana D. Kang</span>, <span class="highwire-citation-author" data-delta="13">Sandip Vibhute</span>, <span class="highwire-citation-author" data-delta="14">Dasheng Wang</span>, <span class="highwire-citation-author" data-delta="15">Chad E. Bennett</span> and <span class="highwire-citation-author" data-delta="16">Christopher C. Coss</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 27, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2023-001874; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.123.001874 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/27/jpet.123.001874.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last even"><div class="highwire-article-citation highwire-citation-type-highwire-article node156126" data-node-nid="156126" id="node-156126--2205041806" data-pisa="jpet;jpet.124.002298v1" data-pisa-master="jpet;jpet.124.002298" data-apath="/jpet/early/2024/06/27/jpet.124.002298.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002298" data-atom-uri="/jpet/early/2024/06/27/jpet.124.002298.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/27/jpet.124.002298" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">VERU-111, an Orally Available Tubulin Inhibitor, Suppresses Ovarian Tumor Growth and Metastasis</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Shelby Waddell</span>, <span class="highwire-citation-author" data-delta="1">Guannan Zhao</span>, <span class="highwire-citation-author" data-delta="2">Ziping Liu</span>, <span class="highwire-citation-author" data-delta="3">Hao Chen</span>, <span class="highwire-citation-author" data-delta="4">Wenjing Zhang</span>, <span class="highwire-citation-author" data-delta="5">Yaohong Wang</span>, <span class="highwire-citation-author" data-delta="6">Duane D. Miller</span>, <span class="highwire-citation-author" data-delta="7">Junming Yue</span> and <span class="highwire-citation-author" data-delta="8">Wei Li</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 27, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002298; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002298 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/27/jpet.124.002298.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">June 10, 2024</h3><div class="highwire-list"><ul id="june-10-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155981" data-node-nid="155981" id="node-155981--2190430959" data-pisa="jpet;jpet.123.002050v1" data-pisa-master="jpet;jpet.123.002050" data-apath="/jpet/early/2024/06/10/jpet.123.002050.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.123.002050" data-atom-uri="/jpet/early/2024/06/10/jpet.123.002050.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/10/jpet.123.002050" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Therapeutic targeting of full-length interleukin-33 protein levels with cell-permeable decoy peptides attenuates fibrosis in the bleomycin model in vivo</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Sergei P. Atamas</span>, <span class="highwire-citation-author" data-delta="1">Virginia K. Lockatell</span>, <span class="highwire-citation-author" data-delta="2">Nevins W. Todd</span>, <span class="highwire-citation-author" data-delta="3">John C. Papadimitriou</span>, <span class="highwire-citation-author" data-delta="4">Violeta Rus</span>, <span class="highwire-citation-author" data-delta="5">Katerina N. Lugkey</span>, <span class="highwire-citation-author" data-delta="6">Stefanie N. Vogel</span>, <span class="highwire-citation-author" data-delta="7">Vladimir Y. Toshchakov</span> and <span class="highwire-citation-author" data-delta="8">Irina G. Luzina</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 10, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2023-002050; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.123.002050 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/10/jpet.123.002050.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last even"><div class="highwire-article-citation highwire-citation-type-highwire-article node155982" data-node-nid="155982" id="node-155982--236682289" data-pisa="jpet;jpet.124.002121v1" data-pisa-master="jpet;jpet.124.002121" data-apath="/jpet/early/2024/06/10/jpet.124.002121.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002121" data-atom-uri="/jpet/early/2024/06/10/jpet.124.002121.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/10/jpet.124.002121" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Long-term treatment with the streptococcal exotoxin streptolysin O inhibits vascular smooth muscle contraction by inducing iNOS expression in endothelial cells</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Mihiro Seki</span>, <span class="highwire-citation-author" data-delta="1">Masashi Mukohda</span>, <span class="highwire-citation-author" data-delta="2">Hirotaka Tajima</span>, <span class="highwire-citation-author" data-delta="3">Nayu Morikita</span>, <span class="highwire-citation-author" data-delta="4">Ryuya Imai</span>, <span class="highwire-citation-author" data-delta="5">Kazuhide Itaya</span>, <span class="highwire-citation-author" data-delta="6">Risuke Mizuno</span> and <span class="highwire-citation-author" data-delta="7">Hiroshi Ozaki</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 10, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002121; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002121 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/10/jpet.124.002121.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">June 07, 2024</h3><div class="highwire-list"><ul id="june-07-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155966" data-node-nid="155966" id="node-155966--21178494172" data-pisa="jpet;jpet.124.002120v1" data-pisa-master="jpet;jpet.124.002120" data-apath="/jpet/early/2024/06/07/jpet.124.002120.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002120" data-atom-uri="/jpet/early/2024/06/07/jpet.124.002120.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/07/jpet.124.002120" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Pan AMPK Activation Protects Tubules in Rat Ischemic Acute Kidney Injury</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Henriette Frikke-Schmidt</span>, <span class="highwire-citation-author" data-delta="1">Kamal Albarazanji</span>, <span class="highwire-citation-author" data-delta="2">Jenson Qi</span>, <span class="highwire-citation-author" data-delta="3">David Frederick</span>, <span class="highwire-citation-author" data-delta="4">Janos Steffen</span>, <span class="highwire-citation-author" data-delta="5">Shanker Kalyana-Sundaram</span>, <span class="highwire-citation-author" data-delta="6">Rong Meng</span>, <span class="highwire-citation-author" data-delta="7">Zheng Huang Devine</span>, <span class="highwire-citation-author" data-delta="8">Tao Chen</span>, <span class="highwire-citation-author" data-delta="9">Qiu Li</span>, <span class="highwire-citation-author" data-delta="10">Fuyong Du</span>, <span class="highwire-citation-author" data-delta="11">George Ho</span>, <span class="highwire-citation-author" data-delta="12">Jianying Liu</span>, <span class="highwire-citation-author" data-delta="13">Roseann Riley</span>, <span class="highwire-citation-author" data-delta="14">Romer A Gonzalez-Villalobos</span>, <span class="highwire-citation-author" data-delta="15">Raul C Camacho</span>, <span class="highwire-citation-author" data-delta="16">Andrea R Nawrocki</span>, <span class="highwire-citation-author" data-delta="17">Meghan Pryor</span>, <span class="highwire-citation-author" data-delta="18">Min Lee</span>, <span class="highwire-citation-author" data-delta="19">Victoria Wong</span>, <span class="highwire-citation-author" data-delta="20">Rosalie Matico</span>, <span class="highwire-citation-author" data-delta="21">Elsie Diaz</span>, <span class="highwire-citation-author" data-delta="22">Daniel Krosky</span>, <span class="highwire-citation-author" data-delta="23">Mark Wall</span>, <span class="highwire-citation-author" data-delta="24">Elise Gao</span>, <span class="highwire-citation-author" data-delta="25">Akshay A Shah</span>, <span class="highwire-citation-author" data-delta="26">James Leonard</span>, <span class="highwire-citation-author" data-delta="27">Mark Erion</span>, <span class="highwire-citation-author" data-delta="28">Alessandro Pocai</span> and <span class="highwire-citation-author" data-delta="29">Mark R Player</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 7, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002120; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002120 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/07/jpet.124.002120.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="even"><div class="highwire-article-citation highwire-citation-type-highwire-article node155964" data-node-nid="155964" id="node-155964--2258563875" data-pisa="jpet;jpet.124.002185v1" data-pisa-master="jpet;jpet.124.002185" data-apath="/jpet/early/2024/06/07/jpet.124.002185.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002185" data-atom-uri="/jpet/early/2024/06/07/jpet.124.002185.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/07/jpet.124.002185" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Chronic activation of β-adrenergic receptors leads to tissue water and electrolyte retention</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Steeve Akumwami</span>, <span class="highwire-citation-author" data-delta="1">Kento Kitada</span>, <span class="highwire-citation-author" data-delta="2">Yoshihide Fujisawa</span>, <span class="highwire-citation-author" data-delta="3">Netish Kumar Kundo</span>, <span class="highwire-citation-author" data-delta="4">Md. Moshiur Rahman</span>, <span class="highwire-citation-author" data-delta="5">Asahiro Morishita</span>, <span class="highwire-citation-author" data-delta="6">Hiroaki Kitamura</span>, <span class="highwire-citation-author" data-delta="7">Asadur Rahman</span>, <span class="highwire-citation-author" data-delta="8">Yuichi Ogino</span> and <span class="highwire-citation-author" data-delta="9">Akira Nishiyama</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 7, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002185; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002185 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/07/jpet.124.002185.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155965" data-node-nid="155965" id="node-155965--21935614973" data-pisa="jpet;jpet.124.002264v1" data-pisa-master="jpet;jpet.124.002264" data-apath="/jpet/early/2024/06/07/jpet.124.002264.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002264" data-atom-uri="/jpet/early/2024/06/07/jpet.124.002264.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/06/07/jpet.124.002264" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Discovery of Aurovertin B as a Potent Metastasis Inhibitor against Triple-Negative Breast Cancer: Elucidating the Complex Role of the ATF3-DUSP1 Axis</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Jian-Jun Shen</span>, <span class="highwire-citation-author" data-delta="1">Xi Yang</span>, <span class="highwire-citation-author" data-delta="2">Meng Yu</span>, <span class="highwire-citation-author" data-delta="3">Qing-Cui Li</span>, <span class="highwire-citation-author" data-delta="4">Ru-Yu Wang</span>, <span class="highwire-citation-author" data-delta="5">Wen-Yan Yu</span>, <span class="highwire-citation-author" data-delta="6">Jia-Li Zhang</span>, <span class="highwire-citation-author" data-delta="7">Yi-Li Chen</span>, <span class="highwire-citation-author" data-delta="8">Wen-Ting Zhu</span>, <span class="highwire-citation-author" data-delta="9">Jia Li</span>, <span class="highwire-citation-author" data-delta="10">Zha-Jun Zhan</span> and <span class="highwire-citation-author" data-delta="11">Rui Wu</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">June 7, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002264; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002264 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/06/07/jpet.124.002264.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">May 22, 2024</h3><div class="highwire-list"><ul id="may-22-2024"><li class="first odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155938" data-node-nid="155938" id="node-155938--21594483390" data-pisa="jpet;jpet.124.002152v1" data-pisa-master="jpet;jpet.124.002152" data-apath="/jpet/early/2024/05/22/jpet.124.002152.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002152" data-atom-uri="/jpet/early/2024/05/22/jpet.124.002152.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/05/22/jpet.124.002152" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Evaluation of Systemic and Brain Pharmacokinetic Parameters for Repurposing Metformin Using Intravenous Bolus Administration</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Sejal Sharma</span>, <span class="highwire-citation-author" data-delta="1">Yong Zhang</span>, <span class="highwire-citation-author" data-delta="2">Dhavalkumar Patel</span>, <span class="highwire-citation-author" data-delta="3">Khondker Ayesha Akter</span>, <span class="highwire-citation-author" data-delta="4">Sounak Bagchi</span>, <span class="highwire-citation-author" data-delta="5">Ali Ehsan Sifat</span>, <span class="highwire-citation-author" data-delta="6">Ehsan Nozohouri</span>, <span class="highwire-citation-author" data-delta="7">Yeseul Ahn</span>, <span class="highwire-citation-author" data-delta="8">Vardan T Karamyan</span>, <span class="highwire-citation-author" data-delta="9">Ulrich Bickel</span> and <span class="highwire-citation-author" data-delta="10">Thomas J Abbruscato</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">May 22, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002152; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002152 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/05/22/jpet.124.002152.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li><li class="last even"><div class="highwire-article-citation highwire-citation-type-highwire-article node155940" data-node-nid="155940" id="node-155940--2675524582" data-pisa="jpet;jpet.124.002149v1" data-pisa-master="jpet;jpet.124.002149" data-apath="/jpet/early/2024/05/22/jpet.124.002149.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002149" data-atom-uri="/jpet/early/2024/05/22/jpet.124.002149.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/05/22/jpet.124.002149" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Platelet Spreading and Clot Retraction are Regulated by two Distinct α<sub>IIb</sub>β<sub>3</sub> Outside-in Signaling Pathways</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Arjit Nigam</span>, <span class="highwire-citation-author" data-delta="1">Voddarahally N Manjuprasanna</span>, <span class="highwire-citation-author" data-delta="2">Meghna U Naik</span> and <span class="highwire-citation-author" data-delta="3">Ulhas P. Naik</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">May 22, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002149; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002149 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/05/22/jpet.124.002149.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">May 06, 2024</h3><div class="highwire-list"><ul id="may-06-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155327" data-node-nid="155327" id="node-155327--21484009254" data-pisa="jpet;jpet.124.002176v1" data-pisa-master="jpet;jpet.124.002176" data-apath="/jpet/early/2024/05/06/jpet.124.002176.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002176" data-atom-uri="/jpet/early/2024/05/06/jpet.124.002176.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/05/06/jpet.124.002176" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Protease-activated receptor 2: a promising therapeutic target for women's cancers</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Himani Shah</span>, <span class="highwire-citation-author" data-delta="1">David P Fairlie</span> and <span class="highwire-citation-author" data-delta="2">Junxian Lim</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">May 6, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2024-002176; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002176 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/05/06/jpet.124.002176.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">April 26, 2024</h3><div class="highwire-list"><ul id="april-26-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155320" data-node-nid="155320" id="node-155320--21263286565" data-pisa="jpet;jpet.124.002170v1" data-pisa-master="jpet;jpet.124.002170" data-apath="/jpet/early/2024/04/26/jpet.124.002170.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002170" data-atom-uri="/jpet/early/2024/04/26/jpet.124.002170.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/04/26/jpet.124.002170" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title"><strong>Central Nervous System Distributional Kinetics of Selected Histone Deacetylase Inhibitors</strong></span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Wenqiu Zhang</span>, <span class="highwire-citation-author" data-delta="1">Ju-Hee Oh</span>, <span class="highwire-citation-author" data-delta="2">Wenjuan Zhang</span>, <span class="highwire-citation-author" data-delta="3">Courtney C. Aldrich</span>, <span class="highwire-citation-author" data-delta="4">Rachael W Sirianni</span> and <span class="highwire-citation-author" data-delta="5">William F. Elmquist</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">April 26, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002170; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002170 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/04/26/jpet.124.002170.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">April 05, 2024</h3><div class="highwire-list"><ul id="april-05-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155196" data-node-nid="155196" id="node-155196--21500807016" data-pisa="jpet;jpet.124.002110v1" data-pisa-master="jpet;jpet.124.002110" data-apath="/jpet/early/2024/04/05/jpet.124.002110.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.124.002110" data-atom-uri="/jpet/early/2024/04/05/jpet.124.002110.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/04/05/jpet.124.002110" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Deletion of PTP4A3 phosphatase in high grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release.</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">John S. Lazo</span>, <span class="highwire-citation-author" data-delta="1">Kelly N. Isbell</span>, <span class="highwire-citation-author" data-delta="2">Sai Ashish Vasa</span>, <span class="highwire-citation-author" data-delta="3">Danielle C. Llaneza</span>, <span class="highwire-citation-author" data-delta="4">Garnett A Mingledorff</span> and <span class="highwire-citation-author" data-delta="5">Elizabeth R Sharlow</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">April 5, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-AR-2024-002110; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.124.002110 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/04/05/jpet.124.002110.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div><div class="highwire-list-wrapper highwire-list-pap highwire-article-citation-list"><h3 class="highwire-list-title">March 07, 2024</h3><div class="highwire-list"><ul id="march-07-2024"><li class="first last odd"><div class="highwire-article-citation highwire-citation-type-highwire-article node155067" data-node-nid="155067" id="node-155067--2312283095" data-pisa="jpet;jpet.123.002048v1" data-pisa-master="jpet;jpet.123.002048" data-apath="/jpet/early/2024/03/07/jpet.123.002048.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jnl-jpet-list-complete clearfix"> <div class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="jpet;jpet.123.002048" data-atom-uri="/jpet/early/2024/03/07/jpet.123.002048.atom" data-request-view="full"><i class="highwire-access-icon highwire-access-icon-user-access user-access icon-ok-sign" title="You have access" aria-hidden="true" style="display:none;"></i><span class="element-invisible highwire-access-icon highwire-access-icon-user-access" style="display:none;">You have access</span></span></div> <a href="/content/early/2024/03/07/jpet.123.002048" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">Evidence for cytoprotective autophagy in response to HER2-targeted monoclonal antibodies</span></a> <div class="highwire-cite-authors"><div class="highwire-citation-authors-type highwire-citation-authors-type-author"><span class="contributor-of-type"><em></em></span> <span class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ahmed M. Elshazly</span>, <span class="highwire-citation-author" data-delta="1">Aya A. Elzahed</span> and <span class="highwire-citation-author" data-delta="2">David A. Gewirtz</span></span></div></div> <div class="highwire-cite-metadata"><span class="highwire-cite-metadata-journal highwire-cite-metadata">Journal of Pharmacology and Experimental Therapeutics </span><span class="highwire-cite-metadata-date highwire-cite-metadata">March 7, 2024, </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">JPET-MR-2023-002048; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.1124/jpet.123.002048 </span></div> <div class="highwire-cite-extras"><span class="highwire-foxycart-add-to-cart-ahah highwire-foxycart-add-to-cart-ahah" data-text="Add to Cart (%short-price)" data-apath="/jpet/early/2024/03/07/jpet.123.002048.atom" data-type="link" data-font-icon="" data-parent-id="15231"></span></div> </div> </div></li></ul></div></div> </div> </div> </div> </div> </div> <div class="sidebar-right-wrapper grid-10 omega"> <div class="panel-panel panel-region-sidebar-right"> <div class="inside"><div class="panel-pane pane-custom pane-1 pap_link_custom" > <div class="pane-content"> <p><a href="/content/early/by/section">View by section</a></p> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-panels-mini pane-jnl-jpet-dfp-skyscraper-slot" > <div class="pane-content"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_dfp_skyscraper_slot"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-block pane-dfp-jpet-skyscraper-160x600 text-center pane-dfp" > <div class="pane-content"> <div id="dfp-ad-jpet_skyscraper_160x600-wrapper" class="dfp-tag-wrapper"><div class="slug">Advertisement</div> <div id="dfp-ad-jpet_skyscraper_160x600" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-jpet_skyscraper_160x600"); }); </script> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <!-- /.panel-row-wrapper --> </div> </div> </div> </div> </div> </div> </div> </section> <footer id="section-footer" class="section section-footer"> <div id="zone-postscript" class="zone zone-postscript clearfix container-30"> <div class="grid-28 suffix-1 prefix-1 region region-postscript-fourth" id="region-postscript-fourth"> <div class="region-inner region-postscript-fourth-inner"> <div class="block block-panels-mini block-jnl-jpet-footer block-panels-mini-jnl-jpet-footer odd block-without-title" id="block-panels-mini-jnl-jpet-footer"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panels-960-row jcore-row-4col clearfix" id="mini-panel-jnl_jpet_footer"> <div class="panel-panel panel-region-col-1 grid-7 alpha"> <div class="inside"><div class="panel-pane pane-snippet pane-jnl-jpet-footer-menu-first-column" > <div class="pane-content"> <div class="snippet jnl-jpet-footer-menu-first-column" id="jnl-jpet-footer-menu-first-column"> <div class="snippet-content"> <style type="text/css"><!-- #snipsocial a i { color: #ffffff; } --> </style> <nav class="navcontainer"> <ul style="list-style-type:none"> <li><a href="/">Home</a></li> <li><a href="/alerts">Alerts</a></li> </ul> </nav> <nav id="snipsocial"><a class="link-icon-only link-icon" href="https://www.facebook.com/jpetaspetjournal/" target="_blank"><i class="icon-facebook-sign icon-2x"><span class="title element-invisible">Facebook</span></i></a> <a class="link-icon-only link-icon" href="https://twitter.com/JPET_Journal" target="_blank"><i class="hw-icon-x-twitter icon-2x"><span class="title element-invisible">Twitter</span></i></a> <a class="link-icon-only link-icon" href="https://www.linkedin.com/groups/3320218" target="_blank"><i class="icon-linkedin-sign icon-2x"><span class="title element-invisible">LinkedIn</span></i></a> <a class="link-icon-only link-icon" href="/content/rss"><i class="icon-rss-sign icon-2x"><span class="title element-invisible">RSS</span></i></a></nav> </div> </div> </div> </div> </div> </div> <div class="panel-panel panel-region-col-2 grid-7"> <div class="inside"><div class="panel-pane pane-block pane-menu-navigate pane-menu" > <h2 class="pane-title">Navigate</h2> <div class="pane-content"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf" role="menuitem"><a href="/content/current" title="Menu to navigate current issue" class="" data-icon-position="" data-hide-link-title="0">Current Issue</a></li> <li class="leaf active-trail" role="menuitem"><a href="/content/early/recent" data-hide-link-title="0" class="active-trail active" data-icon-position="">Fast Forward by date</a></li> <li class="leaf" role="menuitem"><a href="/content/early/by/section" data-hide-link-title="0" class="" data-icon-position="">Fast Forward by section</a></li> <li class="leaf" role="menuitem"><a href="/content/latest" data-hide-link-title="0" class="" data-icon-position="">Latest Articles</a></li> <li class="leaf" role="menuitem"><a href="/content/by/year" class="" data-icon-position="" data-hide-link-title="0">Archive</a></li> <li class="leaf" role="menuitem"><a href="/search" class="" data-icon-position="" data-hide-link-title="0">Search for Articles</a></li> <li class="leaf" role="menuitem"><a href="/feedback" class="" data-icon-position="" data-hide-link-title="0">Feedback</a></li> <li class="last leaf" role="menuitem"><a href="https://www.aspet.org/" class="" data-icon-position="" data-hide-link-title="0">ASPET</a></li> </ul></nav> </div> </div> </div> </div> <div class="panel-panel panel-region-col-3 grid-7"> <div class="inside"><div class="panel-pane pane-block pane-menu-more-information pane-menu" > <h2 class="pane-title">More Information</h2> <div class="pane-content"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf" role="menuitem"><a href="http://highwire.stanford.edu/cgi/journalinfo?qNum=all&journal_set=jpet&sendit=Submit" class="" data-icon-position="" data-hide-link-title="0">About JPET</a></li> <li class="leaf" role="menuitem"><a href="/content/edboard" class="" data-icon-position="" data-hide-link-title="0">Editorial Board</a></li> <li class="leaf" role="menuitem"><a href="/content/ifora" class="" data-icon-position="" data-hide-link-title="0">Instructions to Authors</a></li> <li class="leaf" role="menuitem"><a href="https://jpet.msubmit.net/cgi-bin/main.plex" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Submit a Manuscript</a></li> <li class="leaf" role="menuitem"><a href="http://jpet.aspetjournals.org/citetrack" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Customized Alerts</a></li> <li class="leaf" role="menuitem"><a href="/content/rss" data-hide-link-title="0" class="" data-icon-position="">RSS Feeds</a></li> <li class="leaf" role="menuitem"><a href="http://www.aspetjournals.org/content/aspet-journals-subscriber-help-and-services" data-hide-link-title="0" class="" data-icon-position="">Subscriptions</a></li> <li class="leaf" role="menuitem"><a href="https://www.aspet.org/webforms.aspx?ekfrm=84" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Permissions</a></li> <li class="last leaf" role="menuitem"><a href="http://www.aspetjournals.org/content/terms" data-hide-link-title="0" class="" data-icon-position="">Terms & Conditions of Use</a></li> </ul></nav> </div> </div> </div> </div> <div class="panel-panel panel-region-col-4 grid-7 omega"> <div class="inside"><div class="panel-pane pane-block pane-menu-menu-aspet-journals pane-menu" > <h2 class="pane-title">ASPET's Other Journals</h2> <div class="pane-content"> <nav class="menubar-nav"><ul class="menu" role="menu"><li class="first leaf" role="menuitem"><a href="http://dmd.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Drug Metabolism and Disposition</a></li> <li class="leaf" role="menuitem"><a href="http://molpharm.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Molecular Pharmacology</a></li> <li class="leaf" role="menuitem"><a href="http://pharmrev.aspetjournals.org" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacological Reviews</a></li> <li class="last leaf" role="menuitem"><a href="http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2052-1707/" data-hide-link-title="0" target="_blank" class="" data-icon-position="">Pharmacology Research & Perspectives</a></li> </ul></nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="zone-footer" class="zone zone-footer clearfix container-30"> <div class="grid-28 suffix-1 prefix-1 region region-footer-first" id="region-footer-first"> <div class="region-inner region-footer-first-inner"> <div class="block block-panels-mini block-jnl-jpet-foot-info block-panels-mini-jnl-jpet-foot-info odd block-without-title" id="block-panels-mini-jnl-jpet-foot-info"> <div class="block-inner clearfix"> <div class="content clearfix"> <div class="panel-display panel-1col clearfix" id="mini-panel-jnl_jpet_foot_info"> <div class="panel-panel panel-col"> <div><div class="panel-pane pane-snippet pane-footer-copyright-text" > <div class="pane-content"> <div class="snippet footer-copyright-text" id="footer-copyright-text"> <div class="snippet-content"> <div style="float:right;">ISSN 1521-0103 (Online)</div> <p>Copyright © 2024 by the American Society for Pharmacology and Experimental Therapeutics</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </footer> </div> <div class="region region-page-bottom" id="region-page-bottom"> <div class="region-inner region-page-bottom-inner"> </div> </div><script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__vbQwZ73SX3evUEnyHfIdkdefjmaibJvWpRz5fkek_AA__3cfWQW8vgZoQX3crzEajjgl0b4gUuju12Vx6v9V_Fvc__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js"></script> <script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__Jd5dsvNznZMdglFu8sSni1wCsUfzvQbApHPAZwt5TY4__65Mqa1DMRwcSvPxjJEn6BXgMm-ckF3oOvkUTG9HRADI__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js" defer="defer"></script> <script type="text/javascript" src="https://jpet.aspetjournals.org/sites/default/files/advagg_js/js__WcTpt-w0y1FyXrxZNriX8Ts1KjsFTDpdvZaw9yhRn24__aFJpdvsZPb1v9rWrq-WXbz_WQ9IThQN-mFTCdm1cfXc__f4AsOcbRHjchAvJjG7WfFm_ajP03jTV9KDUm_eqgLLg.js"></script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- function euCookieComplianceLoadScripts() {} //--><!]]> </script> <script type="text/javascript"> <!--//--><![CDATA[//><!-- var eu_cookie_compliance_cookie_name = ""; //--><!]]> </script> </body> </html>