CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pharmrev.aspetjournals.org",cType: 'managed',cRay: '9219a5d08d3bfd80',cH: 'PhJknP4bhKpjSrrGLdae5CIRcfCUVEBmYwve6tTPlfc-1742184701-1.2.1.1-vlZ.2DzRxfhQG1IA3ZEKTzUAj_Y3fHkWsVZaSLbURPm034iH30W0Ry2974CIh9jq',cUPMDTk: "\/?__cf_chl_tk=CnVy1coxVfMyFp8fcT1.9lt_cQQPqAxztRfKQfdJ4UI-1742184701-1.0.1.1-V2XobmLJ8pJT8NakHnVfHqO8ZouF4k1nJmDhm5BD5Q4",cFPWv: 'g',cITimeS: '1742184701',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/?__cf_chl_f_tk=CnVy1coxVfMyFp8fcT1.9lt_cQQPqAxztRfKQfdJ4UI-1742184701-1.0.1.1-V2XobmLJ8pJT8NakHnVfHqO8ZouF4k1nJmDhm5BD5Q4",md: "gqpxfeX4cQ0yjATTnG4iveNQWfOHw3SmU_4L877UfbA-1742184701-1.2.1.1-S6gwX.oouXz24QvN8G..vkfYg_nH1ezf3XjynXX3VL55BsOZHee6NhdtYPmM583dLjdet59fMz3lQI8A9oEr0LsOc6DbyrU_7DClQoCnOhzZ8kVFhcDGdmywJQUAtSfA7OjQDuIq6Vax_hRYyHtQXmiv481SBc2HuTmWGo4kbFfWx_6qk0t4MV2A7_._8PiEaJZpjVQndJgrFrtiy5SZrSyYs6xzV8gmeMg7cqkqhVmasiNxBBTioZNV49WSFOc7nj1I5iyPjdkjdRVz2dYQYObzYnnXgwKuKxvywcb7fbZIsJNh5rwaKzCAu7bGF4r9KRuOASfDq0rJthVaTR757VUVp7kROkHm0ZNTNwdl60KirqfaLJJMRmhgEWqshUceJnTFNknD5yyvcMeYDW4MwSgkZV.ivWUgufJL0_268D1gF8QNIBSrOo0mmcHl5BCbg9k9hn_b5THYc77CXx0P_oyFckwaIQ1V_5PCX22YxZsFFMQo1O.h.Gj5s93v_twwY4z1NYuUWxQ7vWWPPQupyME3drgYRsyEL41VLghrqZdWGCyJwM.1XnxYELDSS5hmHNEOA8d5OyQbm5A3IpUg.L5v9V8wBHqIK7MlpZPrVX2fffFPHlIRWhbuVBPZnTF3l50QrA6844oh.72jCA_jQ5oc6SYbRh7gkd5jFfrwl5vpaWnk09MI05O5qlAcNozFTlVQuIBnffy5HN6X.93ImPLg9JfnXE12.9bAckN6hZxB1je1wKTVKT6dU9yYm3qkaAPAELGzJRR4A2VGncmw1rrKxOvUDRSvKRvhBI7A8jTqbiN9Sfo3o_wX_L0LrzKna7SACnfUtGtCaMKiBiOCB6rMJMikJ3dxbAJHWJ6xqbxBFlY86.TLioEHm0TA_d1c0Vh1QYp4devfCLj66GtUNXNKN9KnqDPcPpujmK2ap8QvkKLJQS_rVpG6TWDYQJy5n.vL3v0W.fkCEyUSVmY1L3Kwj3ebOpzXXGlh46qMvEam6wQKxLA7IdjHcqFJ2KZ1kyrmneduIZXz.rq1CveHYjbb1kU.qOzJpEF9z6BLf_C.23ic5XBlKABj8_RSKFDBHc3PWtzXv6ystPoPr4yKQCYSJrZnEpsFZLjBDvLM4Eksl5q8ZMzaogbGTJp6LX7Ka7OoACXyI1b62FsfaNar7Wki0_AAPhh48okpvqmu.kX6e7PBYA.Eom25Jm80hDp6rR12mC4wNLb7oM.cZTv49w",mdrd: "hWXEdeflVOFffQ9FsHm9ZyWJQVKjKSBBhKM3BR3aaB4-1742184701-1.2.1.1-rhH75nrlF5BrY.AgrzelSKPVvbo1Zu_j.llajPrdvgKq_LkQczLvmWrQon6fXaeITA.csXRYfOom1z.U3PwmbEhAq4Lfrus2dy7.GF3cz.f61aK9b_hHZwtUdTgGEHyaTGYHTCO6DFHQo5DhFJ9.s0kbVaWcjphZZMjCEisKKqAIo4pdoD.u8Eizpm7CRyutTBkVos_9v4z7MuRAi1rJAws9c6KiI8j6hxQGJ0WVnI6wT9gJZ9VyIn.exVF3Z0gZC41yD2vJkLQQrMwHwyn53ujF2AcNchGiJzUDSd2b9kX2TUlmaY4kYyUJJN5XIz8y1ibjmabnXb81O7qZCbCorn3oIIrU5afvXBgzrNJ5CC_w5s63nEBhyWf5qjrMGeqDj82oJwSlU1i0.eg5ZHD.jLnlQjWFcNLGo1T_upXEFYpovlR6twfxfNn4tkyPsYOfAS27Gcj0b4WFuiXm9GKlqoolKxskvXvIeBILtbcpd8WVtNouPnYf1NixCOmjooUWMACCf8bxVole4ziVwzGt_ZvWiFC3frEEMCjWuYDny6oXL7toV.Px7YT8Q3MKObDILBF2Rre3Z.vHD02sIc7lD5qrDopXZmwU8aiOqXb0cVxGb0dtwOhP9YuWqlxfzkQeq_t1qUmwCvPy8houIVA7eudcNZhgrF5YFFJxTEZRFDFrQ4k3i1DFKCBlCqSrC3lJTsJBUJVi6GHmWs20dBuh2rmSICVcWcvzQ0k2UM2wkxC5dJ8rIGvvo4XlBEYtLkYOOoM2NsbzOLk_ZqMmX3839WIywP68Lbfwd3SMFuEBFnt76VDJvj1S.r.4C8EtZusr1q9ki.D_04h36V51RjMWm2jljTa48pPAUIKxZWvwIxP9HxBmR7r.akNUxUqI_xjL2ZaYs0WB21NkY9o8zeVaBbBOD04thqEk58UOr9uKZ5EQ7MlE2d2MHhjeT5nQZeFj3mCskPg93jbhFci.jrpBrxoT0AtJVFBOoNjy2iT4zuoOXanyEtfLemH51rwUqnpNAtuckAhOAI9iMtS1PUc2hjRQ_iXE.zqwg8sONyt.S5haNCEfmLa90oo85IuUH.C1HBMsYJCx6kjzi7XPUakkziA7lZ6KIo7I7jp5MNistQUqonv8eZoLf5oE8kQtXBlw7augVmAH6bSP1TtmjLPGgDDEmVqOBNtgGDuF2yDoMn0_I5N2jJQdEMvQCN286b2ZpDjVevsrceglL7T1YtfRTwqt2GL9N.l1oNpepihk8D_nlCQIEHOvs8u0f_dWS3t0T69p0QnWBug0Vn0bNMO57t7vEXMsM9llHIHm65Se91.W5x3ltwiIZmnRUn87NOHKsFq50shPkji0b4ytxyEkyv7VvF8COYCXhJP16xgyifvHbU9a56.BVHH4OOeklrdKeCIJD.2gkSzjB4CbsSQRFnz0X03xgy70sa8tqQ9Rw09Is.hVHjHLcW8ZayvGTSfXUV9XRNCDNvU13RH5WmSYo23kAl3iNacwrYd4lOh9NtBVGazA9uSG2TyaeVootPyYSip.ILaiHIPslZJMPk2aRqaEotMlvjAbtl2GBzMfeNsXztcl8LuYqrnQneQgPvOwCrdrghawg5hiKhsQQzClmpvsv_KlLcdcZRcLrl49CQTE5bFrtQZTLBneIxzGlbWbzObT2Ol9LGkpjvufZVD67ImObbcHnu1HC_X6RQrn_2QHY2Cj9XP_s7VTxgkx8Xfl7Wy7FAfooshbWstY3pLH6ajDa4FNDpcQNnieLMZicDAY9lcmvmOjWcS4jbWG16wEc46jkBgAZmFYSfT3RWH.WJRINe64IOOT8zu3FZqWYBjfGXNlLw1jz00wVHJkWJGeRGHvGRFcwVoB3tWMnzpqJ2hmjTbu6vMOzuEGtd.bDInFEMPTszJ8FO1M1Y.Hq_Z8EDcihKS7O3Ia8BTiwvWZT1fgZ9vpBnzASos14aYp8_QYAnL5wRweV1S3SOscJaZgs1E8YVK6blwQ24SdSzganqrDy3b6EPppAzUwzpZoun.wCT1q103pbsHGOPJy5V_5tv6W5OV2sLBSQClvh6d_dqkLgkzNeFrziWXdxov7how"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=9219a5d08d3bfd80';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/?__cf_chl_rt_tk=CnVy1coxVfMyFp8fcT1.9lt_cQQPqAxztRfKQfdJ4UI-1742184701-1.0.1.1-V2XobmLJ8pJT8NakHnVfHqO8ZouF4k1nJmDhm5BD5Q4" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>