CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "jpet.aspetjournals.org",cType: 'managed',cRay: '91399501db939bab',cH: 'n_8kRPS.vWYIl2rKiX0jYq8022lqLuBqysZGNs6QtX8-1739835202-1.2.1.1-sLMgakmMt0Cs.Sgk0pNlRK43mvDdHwr.UnTQviMPXI3auZTiK5VgY28Gddi8KLa4',cUPMDTk: "\/content\/early\/2024\/10\/08\/jpet.124.002104?__cf_chl_tk=VJg72cO.U864cbmJYXi7MFz.gV5zl0XZQKBF8_HhO7M-1739835202-1.0.1.1-Wdti9yUN.gIULpprc6Dbm7SyfLUiWFvPngPx7jn.ujM",cFPWv: 'g',cITimeS: '1739835202',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/content\/early\/2024\/10\/08\/jpet.124.002104?__cf_chl_f_tk=VJg72cO.U864cbmJYXi7MFz.gV5zl0XZQKBF8_HhO7M-1739835202-1.0.1.1-Wdti9yUN.gIULpprc6Dbm7SyfLUiWFvPngPx7jn.ujM",md: "HMONYTtoMEpEqY4_enrmnpLHPOpr.k9Do2kA9l_1kNs-1739835202-1.2.1.1-M0FuNCefzCnS_QQOzQrnrlXP40LEUQGvSUChZTUYySGGlTb0UyZY_sZsmm_mHrsH9VWoCMvDmkzx.Uk79Zq4GLT9memJPf9JsB6GV7Pbe.Dz0hUfRqc1R_X.Lu3312M6HKuvdgJyjkDUG9aGkUtqqnsKkvdBwo9h7Iax2FTfoxMQxa7kTWYgLENl0knVodJeA3kuzv2GB_SYZpLwogfPN4hphqIzVMrn4FBzDvrZgrm.zJEa6V4UF10Mb4w79bU.lrJXXgVVljAODWQDUjdDmVYY2vPIreeZzS256JsXukip5dV_DCLdv_w4XGr53NVTebRSZJyq_9cxamNajrRMriG.x7pbzffurA1f2dvU4DGJhpb_b5CX7aLq0mNyb.1uvj301whG8GawRgk2iP901uz5duA2aBmX7q_J7QeL_iBu4KkmciCi2Hl5TnWVINK_FJR5WD_QRF95tmSwLAlqNX1OJMfmOsavRn_UhGo3ngJ.qDuMjizLWXvjTL_6L_mwKV2fRGcRbDt5JLsbJYucFUOzu.5FdiVHkX73tCMQkT1K3bB0Lee.gyaxAy8tA4KxQjOhfe4QO5z744MumrKojwas_Mbb8htXhjxkJj58k3efnMjJKdE3hMqArPecsfnR.tl0i0XPd1PtQwvTZb2_9Pk88HU7W1rDfVHFmmgtEngcqPjb1JAdBmZgFv_Rt5saPBLb0CGk8XA3vWXlo900nnUnpYqyZdxfqqM.MXhLWgj4KEe1HLGhyE1g3p8hEMWLEJOCS3.TOnO5cmPuXwAlahWZa_CBW_MFyZTdWAlwzDbHKQWuyNuqP8ugWbz3H_WZiOpgx7dCYnaM8g61YezTGuXWUvhYXAUQ_3Vzsf91jd._NAMarTqVNgMJpmj7q5j_crDXhQTtmHEkBiFn3Lh2VutlrlYQVd657TkCnF4dFzVM8SmVxLMNNG8D9Cn8.vMLzrOvrQrE_R8MCG37W4P2c460Wna1MzaZTTG2HeHrvQnhL25yrtp6plwTiaipe9.IdcmY81FuQl4CM8W_EfuI.WU275th1yQ8QNmkGmnnII0OkEj96ZPTzcShyisHa.0_juo30_AeH1vreJKTU20x.A5209f4AN77VDnhdlWnrOcQ1TqygUMlOzLoe5EsAtI7z3ukkrPa2LIRh_yBb38qyZDjR3sss_nwANWfOTl2fgq8ChzYRWxBKwd8oEIPKf.oW0z_nJsirBPRxSqgsvw5rQJ7xa36DkFBskzCl9jwJboxUUIFA1rSR8ibrIvDl555Ly8WHraqJEEH6RD5X5sFbwEH1JdOUzSpPrdBN6XU_B89_pU2DP5IK6ZFY3uBFesup486cGj3odYEBRm10kEaTAB3dIdPMBDxOkGY8Laox43hZ_5nSiLS8j_Qe8VWGsBgacclKeg6rFfILa9EQTHoEl0ZQ4SikKrM2vchUqVypCks9XmXD8fx6PYvIDSRu9KScY03IM7qVdW2TvxAdgFjb9eCcQfQqRfoNaLDY6SBTcCpYsIGwgvw4The2ffYPgqvjKdsvKkMdEM_NtYfivmMwoRnmuHqz3knSSZQWKMLTEHiYVrYFtdI4ya5P28UbUgOJ.7o4VQMQ6CKORocX4FqOhKxOh.Nsj9VJBrhqgEhB.ehZPlP.eNa.WuAggK4D3rGKVQk3c85cQFPSGDGQ1eYS1zmt6xhTrlUTnu6iTWfsE0FT61nEbCsElo6_nd27n7spleSx1PfxuTOOzjQv2JrP2S032Kw.7YlKhN6W.fMSWDL_lyt8buVF1W32qwXtF.OpmN5HBOBwxFVeJBTu0aGW1F3uHBNnOs3Nn2rz4vtOR7_aywRlfSt_JXBInn.MMhSe7TmhIaR.kIbbs.K5lied6VrtD8Gd5cbwctfvwyimOydaNr6DOMAlFJ4Sl7jtShcCwy8Zv3PZZcuR.q2mBvUENYJVzBDHA9aI.LjSIQRtpvuvVijna6HiYSP8n3WxX7x_p5b3.92NrWlxs3g180qTa42QBvZnm9COs_gJiXimV40gbnY1XYzKyBG4qrRFg7QvP7YMRFari5hQc7ESkq4lRT1ULD4qdseU8lJRlIk85pYvg9sJdkwispmTIN8syJ1_Q2VoPPM0Gfe0z_klwpqfnEw9GLDfPC_FIwtDM2bUkK89Bsl0kvyWLSiPACzA.m0Kh6sQ_VUgi8.d.DTAcWRcfOmxPOvpOwGf4bA2cBcuJwLAwDzUk3mYCeg5aaoUtR469.Q8TRcnOAHYHpnOFvvnVL_PmkWH4Pws3bGWpceqtyKlnafQu2vGLzQoNmIRHgQS1AqoVNeath2aa6RyC4s2.2Xyy0OL6PitjHrrilloFsC5VJVmxic684AJPYnf7LN4_.I1tnbkxBI8FhmwsS0FXNQu3fH04brmS3MdJ9P_dn4xS9RFhBtJs1zN_GAMxgchqCDSSb3DBA.ARpjSQmhkBTCX.joqVn4xe_MmDHAnYOg3T5LtEAve2pvust.mAXjAYvEa.7MVZhMIXENJ7vKzY_V72JDqWU7bvnv0E9V6PYhz1zIh6tpN_f6BfELoVGfBaETMTVIwQN8V0nwb270gRW5opG5UYSMwa8m1o1SJFqRKdzgLkmCOMKhYQz17GokY6vW8LjQoEpCNIG1OvODvg",mdrd: "OosN49kh4x1cs4_j7QfGdHZjfePg2qPcQMfvBBMalnY-1739835202-1.2.1.1-lJdvog1NmR.PknBNipuKO5whUtHjG4QZKl3fXIvvH.odzCUDQTFEykUYl04c9wLpd4g0jwT_bc.8U0k7sV7KO6XqoZdD8m2YfT46jfbahz61_DdtasTBIiMWUMdRp3XL0aoIiMxn6V7lRjnJCFpdXzMUPrKLjySwhjXH9Gs2h2d_IXJnsz6aB.v63NiInaU42au.DCvP1euVCnp08YF0pvCFFxKmd4_HLnfq_eh8zVDLAHm7HJJ8MndTUIUWW0TwrEMhwQZzLgXLwwT7ia7Bc50xeq_LdjA106wOEdHPCNXTluEc7wGcUGR4GWh_qtKmguXSKMajeZzcXe9kDvIv4p2NLSYUjYVj6ejEI97wAZ7dZ4vTgMONDY5NCbolAkGcMitcbYgt2.B2KYoe1pNGbcQ_zLYMJkiDjQdWeeWlbXqK6HsxUZY_MUyXtUxh9YFsRn8tgR21L7IfL8o3SQOz6mBV3olB8mQI3DDkAwtZD68Zi5oouZNLWmBFhdO4PBVWUhXtwX98sOH6iy33OnHiOe8aX5QgHkZZLWOBbaGRE99SnTV5obEI8B9A0E_lKPtliEatirOsz6mo92LVn9wi8nFEUySmTfIMLi6q_uSxrJ84YJLVkAndAeBAaWvJ3LIxr9iD8MGW4lCt.QWXJJ1tp.zWC_F6YZe04lBxh1AJRlS_OaAvDTYKOiBFs.FIDxp4D0vRASqZsupWY7aSyo5degAn0D0gEZdv0yy7sp0xSTPML3XQnQ.uJUvuQkqLiBaAnyltJOQPR9PZCq.jxy6Tq3Lk4cSpA3UEurh.eepm_O0b2bAIGLw9W2XyR6VgvGUzWDh8UXqSBXhlc6tDZBmuOXBenbNn73FzBu0ONCJfK9NSGQFNSAvAci.liO2haNNIx2uF.J4YwLmxVnbua9LCVS9rLRb_TED7pi2B2e1opjNznF0iT1TORepIIbQS75QwvRkoxpFO92GbckhQ0IotQn_mz40ktNONW5SICExbj4Gb4oh31VS7zKtDb79sk.PaTJvncTX3XDWO8mMFPShzNDwP6GR1aVFzOYkB0oCYGFqRqDSvtr83KICt3qXiCEDrRqtQQXlWwltKr2tMFGIg3FV5JxiOb3UZ7XDYMyTLbGLutE9ILIiGZYdZQhalszh53emgCc5hoiCZ1kENBtAnVMf4gZMmWKhJRqN9BUHIDcUt6nViwj4lzJcCYZroQNb3.HiczpfztVULanxThbD3vxF7H2MirLoAzOq1GCJdO.6FLISd6BOxbJXF5Fj.oJxeTuYgCsSZbZ0yJpPUXL23IQD7Vd5W7Eu6Jv3ZxQGCPxfeDVfx5bn968JaMAcuKErpAg_l1TZ4AB0dO0hAUTd0cu8hQgXUfjtK6CuL2OvegvCx_1Sx2QQXrHpzC7jlEumnzs.sVludnImA9Dzgj1zYFp907i_6xURD9Y.MU6NjiEtlYhLSRoDdURWM0QGAg_8yOdVReI.ASYCsSj.P7Q8SkOBt_m7CWSMf__JMfqz61I17JPE2tnBHMsLr_zYgMuerAi5uwoyiHG0MnS2HECXoiHsMZRiIspm8KxhxQEPmL1JPtmsjydw2Gbux77HqDJ4x_kwKnN9ry8Rnee_22dxx1YLZPnizMlunafdV3NgLmrrCODYfiAhkT0ZFwuZVbgQKF2JBmNFEOqn3LC0sI5VHl0H2L5Rn5tvDYedtmwBynjyAEESuU.yAsfctp1GJJXOJf_n2eQ9fRtmcnH4iromgp2Q57fCe7izO36xRVpWCMU8499U2N.4dZJPXIU7nwfiBlH2lrGUDPjfE0fN3GMIKzj7VD5VSaThGMv7AshrvuzEjLALIyCQThwHen_PuQpFraPaO25TRi91fTw4CwUF1.k5eHsqgCNBoLsh1Sqz82FsccdKp8yXoSAK2bLZalbsBmeprhcfVoOORTHDnfZeV5odxqKBodmXljnQdMOZ_jJZr9DRCE_k3642CBt6M7CobLQekowq280CbCWqI2ezqtw"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=91399501db939bab';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/content\/early\/2024\/10\/08\/jpet.124.002104?__cf_chl_rt_tk=VJg72cO.U864cbmJYXi7MFz.gV5zl0XZQKBF8_HhO7M-1739835202-1.0.1.1-Wdti9yUN.gIULpprc6Dbm7SyfLUiWFvPngPx7jn.ujM" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>