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class="vector-toc-numb">5</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon 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lang="cy" hreflang="cy" data-title="ACVR2B" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-arz mw-list-item"><a href="https://arz.wikipedia.org/wiki/ACVR2B" title="ACVR2B – Egyptian Arabic" lang="arz" hreflang="arz" data-title="ACVR2B" data-language-autonym="مصرى" data-language-local-name="Egyptian Arabic" class="interlanguage-link-target"><span>مصرى</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/ACVR2B" title="ACVR2B – Ukrainian" lang="uk" hreflang="uk" data-title="ACVR2B" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14905179#sitelinks-wikipedia" 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</div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to 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typeof="mw:File"><a href="/wiki/File:Protein_ACVR2B_PDB_1nys.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Protein_ACVR2B_PDB_1nys.png/250px-Protein_ACVR2B_PDB_1nys.png" decoding="async" width="250" height="223" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Protein_ACVR2B_PDB_1nys.png/375px-Protein_ACVR2B_PDB_1nys.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Protein_ACVR2B_PDB_1nys.png/500px-Protein_ACVR2B_PDB_1nys.png 2x" data-file-width="867" data-file-height="774" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P27040%20or%20Q13705">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P27040,Q13705">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2QLU">2QLU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4FAO">4FAO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2H62">2H62</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/174">ACVR2B</a></span>, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/602730">602730</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:87912">87912</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=863">863</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ACVR2B">ACVR2B</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000114739">ACVR2B - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_3.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/450px-Ideogram_human_chromosome_3.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/600px-Ideogram_human_chromosome_3.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_3_(human)" class="mw-redirect" title="Chromosome 3 (human)">Chromosome 3 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_3_ideogram.svg" class="mw-file-description" title="Chromosome 3 (human)"><img alt="Chromosome 3 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/300px-Human_chromosome_3_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/450px-Human_chromosome_3_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/94/Human_chromosome_3_ideogram.svg/600px-Human_chromosome_3_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 51.668037395286px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ACVR2B"><img alt="Genomic location for ACVR2B" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 57.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ACVR2B"><img alt="Genomic location for ACVR2B" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">3p22.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">38,453,890 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">38,493,142 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/260px-Ideogram_house_mouse_chromosome_9.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/390px-Ideogram_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/520px-Ideogram_house_mouse_chromosome_9.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 9 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/300px-Ideogram_of_house_mouse_chromosome_9.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/450px-Ideogram_of_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/600px-Ideogram_of_house_mouse_chromosome_9.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 276.10932085791px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ACVR2B"><img alt="Genomic location for ACVR2B" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 282.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ACVR2B"><img alt="Genomic location for ACVR2B" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">9|9 F3</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">119,231,184 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">119,264,061 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000114739">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">endothelial cell</li><br /><li style="line-height: 137%;">parotid gland</li><br /><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">Skeletal muscle tissue of biceps brachii</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">retinal pigment epithelium</li><br /><li style="line-height: 137%;">lateral nuclear group of thalamus</li><br /><li style="line-height: 137%;">Skeletal muscle tissue of rectus abdominis</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000061393">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">Rostral migratory stream</li><br /><li style="line-height: 137%;">somite</li><br /><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">renal corpuscle</li><br /><li style="line-height: 137%;">epithelium of lens</li><br /><li style="line-height: 137%;">epiblast</li><br /><li style="line-height: 137%;">Ileal epithelium</li><br /><li style="line-height: 137%;">mandibular prominence</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">maxillary prominence</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000114739">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ACVR2B_220028_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/3b/PBB_GE_ACVR2B_220028_at_fs.png/250px-PBB_GE_ACVR2B_220028_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/3b/PBB_GE_ACVR2B_220028_at_fs.png/375px-PBB_GE_ACVR2B_220028_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/3b/PBB_GE_ACVR2B_220028_at_fs.png/500px-PBB_GE_ACVR2B_220028_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/93/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004672">protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019838">growth factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048185">activin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016301">kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004674">protein serine/threonine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004675">transmembrane receptor protein serine/threonine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004712">protein serine/threonine/tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016362">activin receptor activity, type II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005024">transforming growth factor beta-activated receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005026">transforming growth factor beta receptor activity, type II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034713">type I transforming growth factor beta receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046332">SMAD binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043235">receptor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048179">activin receptor complex</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007389">pattern specification process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001501">skeletal system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060021">roof of mouth development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035265">organ growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048617">embryonic foregut morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001822">kidney development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001946">lymphangiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030324">lung development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030501">positive regulation of bone mineralization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061298">retina vasculature development in camera-type eye</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016310">phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060836">lymphatic endothelial cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048705">skeletal system morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001702">gastrulation with mouth forming second</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030073">insulin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009749">response to glucose</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009791">post-embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030509">BMP signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060841">venous blood vessel development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042475">odontogenesis of dentin-containing tooth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007507">heart development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001974">blood vessel remodeling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007368">determination of left/right symmetry</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045669">positive regulation of osteoblast differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007178">transmembrane receptor protein serine/threonine kinase signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032927">positive regulation of activin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009966">regulation of signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060840">artery development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031016">pancreas development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007498">mesoderm development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032147">activation of protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009952">anterior/posterior pattern specification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032924">activin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007179">transforming growth factor beta receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0120163">negative regulation of cold-induced thermogenesis</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=93&rn=1">93</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11481&rn=1">11481</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000114739;db=core">ENSG00000114739</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000061393;db=core">ENSMUSG00000061393</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q13705">Q13705</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P27040">P27040</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001106">NM_001106</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007397">NM_007397</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001313757">NM_001313757</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001097">NP_001097</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001300686">NP_001300686</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031423">NP_031423</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr3:38453890-38493142">Chr 3: 38.45 – 38.49 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr9:119231184-119264061">Chr 9: 119.23 – 119.26 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14905179" class="extiw" title="d:Q14905179">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14905180" class="extiw" title="d:Q14905180">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Activin receptor type-2B</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>ACVR2B</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid8161782_5-0" class="reference"><a href="#cite_note-pmid8161782-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9621519_6-0" class="reference"><a href="#cite_note-pmid9621519-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> ACVR2B is an <a href="/wiki/Activin_type_2_receptor" class="mw-redirect" title="Activin type 2 receptor">activin type 2 receptor</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ACVR2B&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Activin" class="mw-redirect" title="Activin">Activins</a> are dimeric growth and differentiation factors which belong to the <a href="/wiki/Transforming_growth_factor-beta" class="mw-redirect" title="Transforming growth factor-beta">transforming growth factor-beta</a> (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of <a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">receptor serine kinases</a> which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with <a href="/wiki/Cysteine" title="Cysteine">cysteine</a>-rich region, a <a href="/wiki/Transmembrane_domain" title="Transmembrane domain">transmembrane domain</a>, and a <a href="/wiki/Cytoplasmic" class="mw-redirect" title="Cytoplasmic">cytoplasmic</a> domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a> of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ACVR2B&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>ACVR2B has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="/wiki/ACVR1B" title="ACVR1B">ACVR1B</a><sup id="cite_ref-pmid8622651_8-0" class="reference"><a href="#cite_note-pmid8622651-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8612709_9-0" class="reference"><a href="#cite_note-pmid8612709-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/SYNJ2BP" title="SYNJ2BP">SYNJ2BP</a>.<sup id="cite_ref-pmid11882656_10-0" class="reference"><a href="#cite_note-pmid11882656-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ACVR2B&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000114739">GRCh38: Ensembl release 89: ENSG00000114739</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000061393">GRCm38: Ensembl release 89: ENSMUSG00000061393</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=93">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D93&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=11481">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span 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the human type IIB activin receptor"</a>. <i>Blood</i>. <b>83</b> (8): 2163–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood.V83.8.2163.2163">10.1182/blood.V83.8.2163.2163</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8161782">8161782</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Expression+of+type+II+activin+receptor+genes+during+differentiation+of+human+K562+cells+and+cDNA+cloning+of+the+human+type+IIB+activin+receptor&rft.volume=83&rft.issue=8&rft.pages=2163-70&rft.date=1994-05&rft_id=info%3Adoi%2F10.1182%2Fblood.V83.8.2163.2163&rft_id=info%3Apmid%2F8161782&rft.aulast=Hild%C3%A9n&rft.aufirst=K&rft.au=Tuuri%2C+T&rft.au=Er%C3%A4maa%2C+M&rft.au=Ritvos%2C+O&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood.V83.8.2163.2163&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-pmid9621519-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid9621519_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFIshikawaKaiMurataTamari1998" class="citation journal cs1">Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y (July 1998). <a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs100380050054">"Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene"</a>. <i>J. Hum. Genet</i>. <b>43</b> (2): 132–4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs100380050054">10.1007/s100380050054</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9621519">9621519</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Hum.+Genet.&rft.atitle=Genomic+organization+and+mapping+of+the+human+activin+receptor+type+IIB+%28hActR-IIB%29+gene&rft.volume=43&rft.issue=2&rft.pages=132-4&rft.date=1998-07&rft_id=info%3Adoi%2F10.1007%2Fs100380050054&rft_id=info%3Apmid%2F9621519&rft.aulast=Ishikawa&rft.aufirst=S&rft.au=Kai%2C+M&rft.au=Murata%2C+Y&rft.au=Tamari%2C+M&rft.au=Daigo%2C+Y&rft.au=Murano%2C+T&rft.au=Ogawa%2C+M&rft.au=Nakamura%2C+Y&rft_id=https%3A%2F%2Fdoi.org%2F10.1007%252Fs100380050054&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93">"Entrez Gene: ACVR2B activin A receptor, type IIB"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+ACVR2B+activin+A+receptor%2C+type+IIB&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D93&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-pmid8622651-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8622651_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAttisanoWranaMontalvoMassagué1996" class="citation journal cs1">Attisano L, Wrana JL, Montalvo E, Massagué J (March 1996). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231089">"Activation of signalling by the activin receptor complex"</a>. <i>Mol. Cell. Biol</i>. <b>16</b> (3): 1066–73. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.16.3.1066">10.1128/mcb.16.3.1066</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231089">231089</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8622651">8622651</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol.+Cell.+Biol.&rft.atitle=Activation+of+signalling+by+the+activin+receptor+complex&rft.volume=16&rft.issue=3&rft.pages=1066-73&rft.date=1996-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC231089%23id-name%3DPMC&rft_id=info%3Apmid%2F8622651&rft_id=info%3Adoi%2F10.1128%2Fmcb.16.3.1066&rft.aulast=Attisano&rft.aufirst=L&rft.au=Wrana%2C+JL&rft.au=Montalvo%2C+E&rft.au=Massagu%C3%A9%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC231089&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-pmid8612709-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8612709_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDe_WinterDe_VriesVan_AchterbergAmeerun1996" class="citation journal cs1">De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". <i>Exp. Cell Res</i>. <b>224</b> (2): 323–34. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fexcr.1996.0142">10.1006/excr.1996.0142</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8612709">8612709</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Exp.+Cell+Res.&rft.atitle=Truncated+activin+type+II+receptors+inhibit+bioactivity+by+the+formation+of+heteromeric+complexes+with+activin+type+I.+receptors&rft.volume=224&rft.issue=2&rft.pages=323-34&rft.date=1996-05&rft_id=info%3Adoi%2F10.1006%2Fexcr.1996.0142&rft_id=info%3Apmid%2F8612709&rft.aulast=De+Winter&rft.aufirst=JP&rft.au=De+Vries%2C+CJ&rft.au=Van+Achterberg%2C+TA&rft.au=Ameerun%2C+RF&rft.au=Feijen%2C+A&rft.au=Sugino%2C+H&rft.au=De+Waele%2C+P&rft.au=Huylebroeck%2C+D&rft.au=Verschueren%2C+K&rft.au=Van+Den+Eijden-Van+Raaij%2C+AJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> <li id="cite_note-pmid11882656-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11882656_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMatsuzakiHanaiKishiLiu2002" class="citation journal cs1">Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M112472200">"Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway"</a>. <i>J. Biol. Chem</i>. <b>277</b> (21): 19008–18. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M112472200">10.1074/jbc.M112472200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11882656">11882656</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Biol.+Chem.&rft.atitle=Regulation+of+endocytosis+of+activin+type+II+receptors+by+a+novel+PDZ+protein+through+Ral%2FRal-binding+protein+1-dependent+pathway&rft.volume=277&rft.issue=21&rft.pages=19008-18&rft.date=2002-05&rft_id=info%3Adoi%2F10.1074%2Fjbc.M112472200&rft_id=info%3Apmid%2F11882656&rft.aulast=Matsuzaki&rft.aufirst=T&rft.au=Hanai%2C+S&rft.au=Kishi%2C+H&rft.au=Liu%2C+Z&rft.au=Bao%2C+Y&rft.au=Kikuchi%2C+A&rft.au=Tsuchida%2C+K&rft.au=Sugino%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M112472200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AACVR2B" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ACVR2B&action=edit&section=4" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=ACVR2B"><i>ACVR2B</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=ACVR2B"><i>ACVR2B</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q13705">Q13705</a></i> (Human Activin receptor type-2B) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P27040">P27040</a></i> (Mouse Activin receptor type-2B) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=ACVR2B&action=edit&section=5" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBurdineSchier2000" class="citation journal cs1">Burdine RD, Schier AF (2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.14.7.763">"Conserved and divergent mechanisms in left-right axis formation"</a>. <i>Genes Dev</i>. <b>14</b> (7): 763–76. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.14.7.763">10.1101/gad.14.7.763</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10766733">10766733</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:34764551">34764551</a>.</cite><span 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src="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/PDB_1nys_EBI.jpg/180px-PDB_1nys_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/96/PDB_1nys_EBI.jpg/270px-PDB_1nys_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/96/PDB_1nys_EBI.jpg/360px-PDB_1nys_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nys</b>: Crystal Structure of Activin A Bound to the ECD of ActRIIB P41</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1nyu_EBI.jpg" class="mw-file-description" title="1nyu: Crystal Structure of Activin A Bound to the ECD of ActRIIB"><img alt="1nyu: Crystal Structure of Activin A Bound to the ECD of ActRIIB" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/PDB_1nyu_EBI.jpg/180px-PDB_1nyu_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/67/PDB_1nyu_EBI.jpg/270px-PDB_1nyu_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/67/PDB_1nyu_EBI.jpg/360px-PDB_1nyu_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nyu</b>: Crystal Structure of Activin A Bound to the ECD of ActRIIB</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1s4y_EBI.jpg" class="mw-file-description" title="1s4y: Crystal structure of the activin/actrIIb extracellular domain"><img alt="1s4y: Crystal structure of the activin/actrIIb extracellular domain" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1s4y_EBI.jpg/180px-PDB_1s4y_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1s4y_EBI.jpg/270px-PDB_1s4y_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/PDB_1s4y_EBI.jpg/360px-PDB_1s4y_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1s4y</b>: Crystal structure of the activin/actrIIb extracellular domain</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2h62_EBI.jpg" class="mw-file-description" title="2h62: Crystal structure of a ternary ligand-receptor complex of BMP-2"><img alt="2h62: Crystal structure of a ternary ligand-receptor complex of BMP-2" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/PDB_2h62_EBI.jpg/180px-PDB_2h62_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/PDB_2h62_EBI.jpg/270px-PDB_2h62_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/PDB_2h62_EBI.jpg/360px-PDB_2h62_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2h62</b>: Crystal structure of a ternary ligand-receptor complex of BMP-2</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2h64_EBI.jpg" class="mw-file-description" title="2h64: Crystal structure of a ternary ligand-receptor complex of BMP-2"><img alt="2h64: Crystal structure of a ternary ligand-receptor complex of BMP-2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PDB_2h64_EBI.jpg/180px-PDB_2h64_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PDB_2h64_EBI.jpg/270px-PDB_2h64_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PDB_2h64_EBI.jpg/360px-PDB_2h64_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2h64</b>: Crystal structure of a ternary ligand-receptor complex of BMP-2</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_signaling:_TGFβ_signaling_pathway" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:TGF_beta_signaling" title="Template:TGF beta signaling"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:TGF_beta_signaling" title="Template talk:TGF beta signaling"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:TGF_beta_signaling" title="Special:EditPage/Template:TGF beta signaling"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_signaling:_TGFβ_signaling_pathway" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_signaling" title="Cell signaling">Cell signaling</a>: <a href="/wiki/TGF%CE%B2_signaling_pathway" class="mw-redirect" title="TGFβ signaling pathway">TGFβ signaling pathway</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Transforming_growth_factor_beta_superfamily" title="Transforming growth factor beta superfamily">TGF beta superfamily of ligands</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Ligand of <a href="/wiki/Activin_receptor" title="Activin receptor">ACVR</a> or <a href="/wiki/TGF_beta_receptor" title="TGF beta receptor">TGFBR</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGF beta family</a> <ul><li><a href="/wiki/TGF_beta_1" title="TGF beta 1">TGF-β1</a></li> <li><a href="/wiki/TGF_beta_2" title="TGF beta 2">TGF-β2</a></li> <li><a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">TGF-β3</a></li></ul></li> <li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a> <ul><li><a href="/wiki/INHA" title="INHA">INHA</a></li> <li><a href="/wiki/INHBA" title="INHBA">INHBA</a></li> <li><a href="/wiki/INHBB" title="INHBB">INHBB</a></li> <li><a href="/wiki/INHBC" title="INHBC">INHBC</a></li></ul></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Ligand of <a href="/wiki/Bone_morphogenetic_protein_receptor" title="Bone morphogenetic protein receptor">BMPR</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">Bone morphogenetic proteins</a> <ul><li><a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">BMP2</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_3" title="Bone morphogenetic protein 3">BMP3</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_4" title="Bone morphogenetic protein 4">BMP4</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_5" title="Bone morphogenetic protein 5">BMP5</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_6" title="Bone morphogenetic protein 6">BMP6</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_7" title="Bone morphogenetic protein 7">BMP7</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_8A" title="Bone morphogenetic protein 8A">BMP8a</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_8b" class="mw-redirect" title="Bone morphogenetic protein 8b">BMP8b</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_10" title="Bone morphogenetic protein 10">BMP10</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_15" title="Bone morphogenetic protein 15">BMP15</a></li></ul></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">Growth differentiation factors</a> <ul><li><a href="/wiki/GDF1" title="GDF1">GDF1</a></li> <li><a href="/wiki/GDF2" title="GDF2">GDF2</a></li> <li><a href="/wiki/GDF3" title="GDF3">GDF3</a></li> <li><a href="/wiki/GDF5" title="GDF5">GDF5</a></li> <li><a href="/wiki/GDF6" title="GDF6">GDF6</a></li> <li><a href="/wiki/GDF7" title="GDF7">GDF7</a></li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin/GDF8</a></li> <li><a href="/wiki/Growth_differentiation_factor-9" title="Growth differentiation factor-9">GDF9</a></li> <li><a href="/wiki/GDF10" title="GDF10">GDF10</a></li> <li><a href="/wiki/GDF11" title="GDF11">GDF11</a></li> <li><a href="/wiki/GDF15" title="GDF15">GDF15</a></li></ul></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">Anti-müllerian hormone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF beta receptors</a><br />(<a href="/wiki/Activin_receptor" title="Activin receptor">Activin</a>, <a href="/wiki/Bone_morphogenetic_protein_receptors" class="mw-redirect" title="Bone morphogenetic protein receptors">BMP</a>, <a href="/wiki/TGF-beta_receptor_family" title="TGF-beta receptor family">family</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR1:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_type_1_receptors" title="Activin type 1 receptors">Activin type 1 receptors</a> <ul><li><a href="/wiki/ACVR1" title="ACVR1">ACVR1</a></li> <li><a href="/wiki/ACVR1B" title="ACVR1B">ACVR1B</a></li> <li><a href="/wiki/ACVR1C" title="ACVR1C">ACVR1C</a></li></ul></li> <li><a href="/wiki/ACVRL1" title="ACVRL1">ACVRL1</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_receptor,_type_1" title="Bone morphogenetic protein receptor, type 1">BMPR1</a> <ul><li><a href="/wiki/BMPR1A" title="BMPR1A">BMPR1A</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">BMPR1B</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR2:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_type_2_receptors" title="Activin type 2 receptors">Activin type 2 receptors</a> <ul><li><a href="/wiki/ACVR2A" title="ACVR2A">ACVR2A</a></li> <li><a class="mw-selflink selflink">ACVR2B</a></li></ul></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone_receptor" title="Anti-Müllerian hormone receptor">AMHR2</a></li> <li><a href="/wiki/BMPR2" title="BMPR2">BMPR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR3:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Betaglycan" class="mw-redirect" title="Betaglycan">betaglycan</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Signal_transduction" title="Signal transduction">Transducers</a>/<a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> (<a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">SMAD1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">SMAD2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">SMAD3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">SMAD5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">SMAD9</a>)</li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> (<a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">SMAD6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">SMAD7</a>)</li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">SMAD4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/TGF_beta_signaling_pathway#Ligand_agonists.2Fantagonists" title="TGF beta signaling pathway">Ligand inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cerberus_(protein)" title="Cerberus (protein)">Cerberus</a></li> <li><a href="/wiki/Chordin" title="Chordin">Chordin</a></li> <li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Follistatin" title="Follistatin">Follistatin</a></li> <li><a href="/wiki/Gremlin_(protein)" title="Gremlin (protein)">Gremlin</a></li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a></li> <li><a href="/wiki/Latent_TGF-beta_binding_protein" title="Latent TGF-beta binding protein">LTBP1</a></li> <li><a href="/wiki/Noggin_(protein)" title="Noggin (protein)">Noggin</a></li> <li><a href="/wiki/Poly(A)-specific_ribonuclease" title="Poly(A)-specific ribonuclease">PARN</a></li> <li><a href="/wiki/Thrombospondin_1" title="Thrombospondin 1">THBS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Co-receptor" title="Co-receptor">Coreceptors</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BAMBI" title="BAMBI">BAMBI</a></li> <li><a href="/wiki/Cripto" title="Cripto">Cripto</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Zinc_finger_FYVE_domain-containing_protein_9" title="Zinc finger FYVE domain-containing protein 9">SARA</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Kinases:_Serine/threonine-specific_protein_kinases_(EC_2.7.11-12)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Serine/threonine-specific_protein_kinases" title="Template:Serine/threonine-specific protein kinases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Serine/threonine-specific_protein_kinases" title="Template talk:Serine/threonine-specific protein kinases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Serine/threonine-specific_protein_kinases" title="Special:EditPage/Template:Serine/threonine-specific protein kinases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Kinases:_Serine/threonine-specific_protein_kinases_(EC_2.7.11-12)" style="font-size:114%;margin:0 4em"><a href="/wiki/Kinase" title="Kinase">Kinases</a>: <a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.7.11-12)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Serine/threonine-specific_protein_kinases_(EC_2.7.11.1-EC_2.7.11.20)" style="font-size:114%;margin:0 4em"><a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (EC 2.7.11.1-EC 2.7.11.20)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Non-specific_serine/threonine_protein_kinase" class="mw-redirect" title="Non-specific serine/threonine protein kinase">Non-specific serine/threonine protein kinases</a> (EC 2.7.11.1)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/LATS1" title="LATS1">LATS1</a></li> <li><a href="/wiki/LATS2" title="LATS2">LATS2</a></li> <li><a href="/wiki/MAST1" title="MAST1">MAST1</a></li> <li><a href="/wiki/MAST2" title="MAST2">MAST2</a></li> <li><a href="/wiki/STK38" title="STK38">STK38</a></li> <li><a href="/wiki/STK38L" title="STK38L">STK38L</a></li> <li><a href="/wiki/CIT_(gene)" class="mw-redirect" title="CIT (gene)">CIT</a></li> <li><a href="/wiki/ROCK1" title="ROCK1">ROCK1</a></li> <li><a href="/wiki/SGK" title="SGK">SGK</a></li> <li><a href="/wiki/SGK2" title="SGK2">SGK2</a></li> <li><a href="/wiki/SGK3" title="SGK3">SGK3</a></li> <li><a href="/wiki/AKT" class="mw-redirect" title="AKT">Protein kinase B</a> <ul><li><a href="/wiki/AKT1" title="AKT1">AKT1</a></li> <li><a href="/wiki/AKT2" title="AKT2">AKT2</a></li> <li><a href="/wiki/AKT3" title="AKT3">AKT3</a></li></ul></li> <li><a href="/wiki/Ataxia_telangiectasia_mutated" class="mw-redirect" title="Ataxia telangiectasia mutated">Ataxia telangiectasia mutated</a></li> <li><a href="/wiki/MTOR" title="MTOR">mTOR</a></li> <li><a href="/wiki/EIF-2_kinase" title="EIF-2 kinase">EIF-2 kinases</a> <ul><li><a href="/wiki/Protein_kinase_R" title="Protein kinase R">PKR</a></li> <li><a href="/wiki/EIF2AK1" title="EIF2AK1">HRI</a></li> <li><a href="/wiki/EIF2AK3" title="EIF2AK3">EIF2AK3</a></li> <li><a href="/wiki/EIF2AK4" title="EIF2AK4">EIF2AK4</a></li></ul></li> <li><a href="/wiki/Wee1" title="Wee1">Wee1</a> <ul><li><a href="/wiki/Wee1-like_protein_kinase" title="Wee1-like protein kinase">WEE1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pyruvate_dehydrogenase_kinase" title="Pyruvate dehydrogenase kinase">Pyruvate dehydrogenase kinase</a> (EC 2.7.11.2)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pyruvate_dehydrogenase_lipoamide_kinase_isozyme_1" title="Pyruvate dehydrogenase lipoamide kinase isozyme 1">PDK1</a></li> <li><a href="/wiki/PDK2" title="PDK2">PDK2</a></li> <li><a href="/wiki/PDK3" title="PDK3">PDK3</a></li> <li><a href="/wiki/PDK4" title="PDK4">PDK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dephospho-(reductase_kinase)_kinase" title="Dephospho-(reductase kinase) kinase">Dephospho-(reductase kinase) kinase</a> (EC 2.7.11.3)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AMP-activated_protein_kinase" title="AMP-activated protein kinase">AMP-activated protein kinase</a> α <ul><li><a href="/wiki/Protein_kinase,_AMP-activated,_alpha_1" title="Protein kinase, AMP-activated, alpha 1">PRKAA1</a></li> <li><a href="/wiki/PRKAA2" title="PRKAA2">PRKAA2</a></li></ul></li> <li>β <ul><li><a href="/wiki/PRKAB1" title="PRKAB1">PRKAB1</a></li> <li><a href="/wiki/PRKAB2" title="PRKAB2">PRKAB2</a></li></ul></li> <li>γ <ul><li><a href="/wiki/PRKAG1" title="PRKAG1">PRKAG1</a></li> <li><a href="/wiki/PRKAG2" title="PRKAG2">PRKAG2</a></li> <li><a href="/wiki/PRKAG3" title="PRKAG3">PRKAG3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)_kinase" title="3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase">3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase</a> (EC 2.7.11.4)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BCKDK" title="BCKDK">BCKDK</a></li> <li><a href="/wiki/BCKDHA" title="BCKDHA">BCKDHA</a></li> <li><a href="/wiki/BCKDHB" title="BCKDHB">BCKDHB</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(isocitrate_dehydrogenase_(NADP%2B))_kinase" class="mw-redirect" title="(isocitrate dehydrogenase (NADP+)) kinase">(isocitrate dehydrogenase (NADP+)) kinase</a> (EC 2.7.11.5)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IDH2" title="IDH2">IDH2</a></li> <li><a href="/wiki/IDH3A" title="IDH3A">IDH3A</a></li> <li><a href="/wiki/IDH3B" title="IDH3B">IDH3B</a></li> <li><a href="/wiki/IDH3G" title="IDH3G">IDH3G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(tyrosine_3-monooxygenase)_kinase" title="(tyrosine 3-monooxygenase) kinase">(tyrosine 3-monooxygenase) kinase</a> (EC 2.7.11.6)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STK4" title="STK4">STK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myosin-heavy-chain_kinase" title="Myosin-heavy-chain kinase">Myosin-heavy-chain kinase</a> (EC 2.7.11.7)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aurora_kinase" title="Aurora kinase">Aurora kinase</a> <ul><li><a href="/wiki/Aurora_A_kinase" class="mw-redirect" title="Aurora A kinase">Aurora A kinase</a></li> <li><a href="/wiki/Aurora_B_kinase" class="mw-redirect" title="Aurora B kinase">Aurora B kinase</a></li> <li><a href="/wiki/Aurora_C_kinase" class="mw-redirect" title="Aurora C kinase">Aurora C kinase</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fas-activated_serine/threonine_kinase" title="Fas-activated serine/threonine kinase">Fas-activated serine/threonine kinase</a> (EC 2.7.11.8)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FASTK" title="FASTK">FASTK</a></li> <li><a href="/wiki/STK10" title="STK10">STK10</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Goodpasture-antigen-binding_protein_kinase" title="Goodpasture-antigen-binding protein kinase">Goodpasture-antigen-binding protein kinase</a> (EC 2.7.11.9)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/I%CE%BAB_kinase" title="IκB kinase">IκB kinase</a> (EC 2.7.11.10)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CHUK" title="CHUK">CHUK</a></li> <li><a href="/wiki/IKK2" title="IKK2">IKK2</a></li> <li><a href="/wiki/TANK-binding_kinase_1" title="TANK-binding kinase 1">TBK1</a></li> <li><a href="/wiki/IKBKE" title="IKBKE">IKBKE</a></li> <li><a href="/wiki/IKBKG" title="IKBKG">IKBKG</a></li> <li><a href="/wiki/IKBKAP" title="IKBKAP">IKBKAP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protein_kinase_A" title="Protein kinase A">cAMP-dependent protein kinase</a> (EC 2.7.11.11)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Protein_kinase_A" title="Protein kinase A">Protein kinase A</a></li> <li><a href="/wiki/PRKACG" title="PRKACG">PRKACG</a></li> <li><a href="/wiki/PRKACB" title="PRKACB">PRKACB</a></li> <li><a href="/wiki/PRKACA" title="PRKACA">PRKACA</a></li> <li><a href="/wiki/PRKY" title="PRKY">PRKY</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CGMP-dependent_protein_kinase" title="CGMP-dependent protein kinase">cGMP-dependent protein kinase</a> (EC 2.7.11.12)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CGMP-dependent_protein_kinase" title="CGMP-dependent protein kinase">Protein kinase G</a></li> <li><a href="/wiki/PRKG1" title="PRKG1">PRKG1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a> (EC 2.7.11.13)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Protein_kinase_C" title="Protein kinase C">Protein kinase C</a></li> <li><a href="/wiki/Protein_kinase_C_zeta_type" title="Protein kinase C zeta type">Protein kinase Cζ</a></li> <li><a href="/wiki/PKC_alpha" title="PKC alpha">PKC alpha</a></li> <li><a href="/wiki/PRKCB1" title="PRKCB1">PRKCB1</a></li> <li><a href="/wiki/PRKCD" title="PRKCD">PRKCD</a></li> <li><a href="/wiki/PRKCE" title="PRKCE">PRKCE</a></li> <li><a href="/wiki/PRKCH" title="PRKCH">PRKCH</a></li> <li><a href="/wiki/PRKCG" title="PRKCG">PRKCG</a></li> <li><a href="/wiki/PRKCI" title="PRKCI">PRKCI</a></li> <li><a href="/wiki/PRKCQ" title="PRKCQ">PRKCQ</a></li> <li><a href="/wiki/Protein_kinase_N1" title="Protein kinase N1">Protein kinase N1</a></li> <li><a href="/wiki/PKN2" title="PKN2">PKN2</a></li> <li><a href="/wiki/PKN3_(gene)" title="PKN3 (gene)">PKN3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rhodopsin_kinase" title="Rhodopsin kinase">Rhodopsin kinase</a> (EC 2.7.11.14)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhodopsin_kinase" title="Rhodopsin kinase">Rhodopsin kinase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta_adrenergic_receptor_kinase" class="mw-redirect" title="Beta adrenergic receptor kinase">Beta adrenergic receptor kinase</a> (EC 2.7.11.15)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta_adrenergic_receptor_kinase" class="mw-redirect" title="Beta adrenergic receptor kinase">Beta adrenergic receptor kinase</a></li> <li><a href="/wiki/Beta_adrenergic_receptor_kinase-2" class="mw-redirect" title="Beta adrenergic receptor kinase-2">Beta adrenergic receptor kinase-2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/G_protein-coupled_receptor_kinase" title="G protein-coupled receptor kinase">G-protein coupled receptor kinases</a> (EC 2.7.11.16)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GRK4" title="GRK4">GRK4</a></li> <li><a href="/wiki/GRK5" title="GRK5">GRK5</a></li> <li><a href="/wiki/GRK6" title="GRK6">GRK6</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ca2%2B/calmodulin-dependent_protein_kinase" class="mw-redirect" title="Ca2+/calmodulin-dependent protein kinase">Ca2+/calmodulin-dependent</a> (EC 2.7.11.17)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BRSK2" title="BRSK2">BRSK2</a></li> <li><a href="/wiki/CAMK1" title="CAMK1">CAMK1</a></li> <li><a href="/w/index.php?title=CAMK1A&action=edit&redlink=1" class="new" title="CAMK1A (page does not exist)">CAMK1A</a></li> <li><a href="/w/index.php?title=CAMK1B&action=edit&redlink=1" class="new" title="CAMK1B (page does not exist)">CAMK1B</a></li> <li><a href="/wiki/CAMK1D" title="CAMK1D">CAMK1D</a></li> <li><a href="/w/index.php?title=CAMK1G&action=edit&redlink=1" class="new" title="CAMK1G (page does not exist)">CAMK1G</a></li> <li><a href="/wiki/Ca2%2B/calmodulin-dependent_protein_kinase_II" title="Ca2+/calmodulin-dependent protein kinase II">CAMK2</a></li> <li><a href="/wiki/CAMK2A" class="mw-redirect" title="CAMK2A">CAMK2A</a></li> <li><a href="/wiki/CAMK2B" title="CAMK2B">CAMK2B</a></li> <li><a href="/wiki/CAMK2D" title="CAMK2D">CAMK2D</a></li> <li><a href="/wiki/CAMK2G" title="CAMK2G">CAMK2G</a></li> <li><a href="/wiki/CAMK4" title="CAMK4">CAMK4</a></li> <li><a href="/wiki/Myosin_light-chain_kinase" title="Myosin light-chain kinase">MLCK</a></li> <li><a href="/wiki/CASK" title="CASK">CASK</a></li> <li><a href="/wiki/CHEK1" title="CHEK1">CHEK1</a></li> <li><a href="/wiki/CHEK2" title="CHEK2">CHEK2</a></li> <li><a href="/wiki/DAPK1" title="DAPK1">DAPK1</a></li> <li><a href="/wiki/DAPK2" title="DAPK2">DAPK2</a></li> <li><a href="/wiki/DAPK3" title="DAPK3">DAPK3</a></li> <li><a href="/wiki/STK11" title="STK11">STK11</a></li> <li><a href="/wiki/MAPKAPK2" title="MAPKAPK2">MAPKAPK2</a></li> <li><a href="/wiki/MAPKAPK3" title="MAPKAPK3">MAPKAPK3</a></li> <li><a href="/wiki/MAPKAPK5" title="MAPKAPK5">MAPKAPK5</a></li> <li><a href="/wiki/MARK1" title="MARK1">MARK1</a></li> <li><a href="/wiki/MARK2" title="MARK2">MARK2</a></li> <li><a href="/wiki/MARK3" title="MARK3">MARK3</a></li> <li><a href="/wiki/MARK4" title="MARK4">MARK4</a></li> <li><a href="/wiki/MELK" title="MELK">MELK</a></li> <li><a href="/wiki/MKNK1" title="MKNK1">MKNK1</a></li> <li><a href="/wiki/MKNK2" title="MKNK2">MKNK2</a></li> <li><a href="/wiki/NUAK1" title="NUAK1">NUAK1</a></li> <li><a href="/wiki/NUAK2" title="NUAK2">NUAK2</a></li> <li><a href="/wiki/OBSCN" class="mw-redirect" title="OBSCN">OBSCN</a></li> <li><a href="/wiki/PASK" title="PASK">PASK</a></li> <li><a href="/wiki/PHKG1" title="PHKG1">PHKG1</a></li> <li><a href="/wiki/PHKG2" title="PHKG2">PHKG2</a></li> <li><a href="/wiki/PIM1" title="PIM1">PIM1</a></li> <li><a href="/wiki/PIM2_(gene)" title="PIM2 (gene)">PIM2</a></li> <li><a href="/wiki/Protein_kinase_D1" title="Protein kinase D1">PKD1</a></li> <li><a href="/wiki/PRKD2" title="PRKD2">PRKD2</a></li> <li><a href="/wiki/PRKD3" title="PRKD3">PRKD3</a></li> <li><a href="/wiki/PSKH1" title="PSKH1">PSKH1</a></li> <li><a href="/wiki/SNF1LK2" title="SNF1LK2">SNF1LK2</a></li> <li><a href="/wiki/KIAA0999" title="KIAA0999">KIAA0999</a></li> <li><a href="/wiki/STK40" title="STK40">STK40</a></li> <li><a href="/wiki/SNF1LK" class="mw-redirect" title="SNF1LK">SNF1LK</a></li> <li><a href="/wiki/SNRK" title="SNRK">SNRK</a></li> <li><a href="/wiki/SPEG" title="SPEG">SPEG</a></li> <li><a href="/wiki/TSSK2" title="TSSK2">TSSK2</a></li> <li><a href="/wiki/Kalirin" title="Kalirin">Kalirin</a></li> <li><a href="/wiki/TRIB1" title="TRIB1">TRIB1</a></li> <li><a href="/wiki/TRIB2" title="TRIB2">TRIB2</a></li> <li><a href="/wiki/TRIB3" title="TRIB3">TRIB3</a></li> <li><a href="/wiki/TRIO_(gene)" title="TRIO (gene)">TRIO</a></li> <li><a href="/wiki/Titin" title="Titin">Titin</a></li> <li><a href="/wiki/DCLK1" title="DCLK1">DCLK1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myosin_light-chain_kinase" title="Myosin light-chain kinase">Myosin light-chain kinase</a> (EC 2.7.11.18)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MYLK" title="MYLK">MYLK</a></li> <li><a href="/wiki/MYLK2" title="MYLK2">MYLK2</a></li> <li><a href="/wiki/MYLK3" title="MYLK3">MYLK3</a></li> <li><a href="/wiki/MYLK4" title="MYLK4">MYLK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Phosphorylase_kinase" title="Phosphorylase kinase">Phosphorylase kinase</a> (EC 2.7.11.19)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Phosphorylase_kinase,_alpha_1" title="Phosphorylase kinase, alpha 1">PHKA1</a></li> <li><a href="/wiki/PHKA2" title="PHKA2">PHKA2</a></li> <li><a href="/wiki/PHKB" title="PHKB">PHKB</a></li> <li><a href="/wiki/PHKG1" title="PHKG1">PHKG1</a></li> <li><a href="/wiki/PHKG2" title="PHKG2">PHKG2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Elongation_factor_2_kinase" title="Elongation factor 2 kinase">Elongation factor 2 kinase</a> (EC 2.7.11.20)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EEF2K" title="EEF2K">EEF2K</a></li> <li><a href="/wiki/STK19" title="STK19">STK19</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polo_kinase" title="Polo kinase">Polo kinase</a> (EC 2.7.11.21)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PLK1" title="PLK1">PLK1</a></li> <li><a href="/wiki/PLK2" title="PLK2">PLK2</a></li> <li><a href="/wiki/PLK3" title="PLK3">PLK3</a></li> <li><a href="/wiki/PLK4" title="PLK4">PLK4</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Serine/threonine-specific_protein_kinases_(EC_2.7.11.21-EC_2.7.11.30)" style="font-size:114%;margin:0 4em"><a href="/wiki/Serine/threonine-specific_protein_kinase" title="Serine/threonine-specific protein kinase">Serine/threonine-specific protein kinases</a> (EC 2.7.11.21-EC 2.7.11.30)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Polo_kinase" title="Polo kinase">Polo kinase</a> (EC 2.7.11.21)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PLK1" title="PLK1">PLK1</a></li> <li><a href="/wiki/PLK2" title="PLK2">PLK2</a></li> <li><a href="/wiki/PLK3" title="PLK3">PLK3</a></li> <li><a href="/wiki/PLK4" title="PLK4">PLK4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyclin-dependent_kinase" title="Cyclin-dependent kinase">Cyclin-dependent kinase</a> (EC 2.7.11.22)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cdk1" class="mw-redirect" title="Cdk1">CDK1</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_2" title="Cyclin-dependent kinase 2">CDK2</a></li> <li><a href="/wiki/CDKL2" title="CDKL2">CDKL2</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_3" title="Cyclin-dependent kinase 3">CDK3</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_4" title="Cyclin-dependent kinase 4">CDK4</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_5" title="Cyclin-dependent kinase 5">CDK5</a></li> <li><a href="/wiki/CDKL5" title="CDKL5">CDKL5</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_6" title="Cyclin-dependent kinase 6">CDK6</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_7" title="Cyclin-dependent kinase 7">CDK7</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_8" title="Cyclin-dependent kinase 8">CDK8</a></li> <li><a href="/wiki/CDK9" class="mw-redirect" title="CDK9">CDK9</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_10" title="Cyclin-dependent kinase 10">CDK10</a></li> <li><a href="/wiki/CDK12" title="CDK12">CDK12</a></li> <li><a href="/wiki/CDC2L5" class="mw-redirect" title="CDC2L5">CDC2L5</a></li> <li><a href="/wiki/PCTK1" title="PCTK1">PCTK1</a></li> <li><a href="/wiki/PCTK2" title="PCTK2">PCTK2</a></li> <li><a href="/wiki/PCTK3" title="PCTK3">PCTK3</a></li> <li><a href="/wiki/PFTK1" title="PFTK1">PFTK1</a></li> <li><a href="/wiki/CDC2L1" title="CDC2L1">CDC2L1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(RNA-polymerase)-subunit_kinase" title="(RNA-polymerase)-subunit kinase">(RNA-polymerase)-subunit kinase</a> (EC 2.7.11.23)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RPS6KA5" title="RPS6KA5">RPS6KA5</a></li> <li><a href="/wiki/RPS6KA4" title="RPS6KA4">RPS6KA4</a></li> <li><a href="/wiki/P70S6_kinase" class="mw-redirect" title="P70S6 kinase">P70S6 kinase</a></li> <li><a href="/wiki/P70-S6_Kinase_1" title="P70-S6 Kinase 1">P70-S6 Kinase 1</a></li> <li><a href="/wiki/RPS6KB2" title="RPS6KB2">RPS6KB2</a></li> <li><a href="/wiki/RPS6KA2" title="RPS6KA2">RPS6KA2</a></li> <li><a href="/wiki/RPS6KA3" title="RPS6KA3">RPS6KA3</a></li> <li><a href="/wiki/RPS6KA1" title="RPS6KA1">RPS6KA1</a></li> <li><a href="/wiki/RPS6KC1" title="RPS6KC1">RPS6KC1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">Mitogen-activated protein kinase</a> (EC 2.7.11.24)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extracellular_signal-regulated_kinases" title="Extracellular signal-regulated kinases">Extracellular signal-regulated</a> <ul><li><a href="/wiki/MAPK1" title="MAPK1">MAPK1</a></li> <li><a href="/wiki/MAPK3" title="MAPK3">MAPK3</a></li> <li><a href="/wiki/MAPK4" title="MAPK4">MAPK4</a></li> <li><a href="/wiki/MAPK6" title="MAPK6">MAPK6</a></li> <li><a href="/wiki/MAPK7" title="MAPK7">MAPK7</a></li> <li><a href="/wiki/MAPK12" title="MAPK12">MAPK12</a></li> <li><a href="/wiki/MAPK15" title="MAPK15">MAPK15</a></li></ul></li> <li><a href="/wiki/C-Jun_N-terminal_kinases" title="C-Jun N-terminal kinases">C-Jun N-terminal</a> <ul><li><a href="/wiki/MAPK8" title="MAPK8">MAPK8</a></li> <li><a href="/wiki/Mitogen-activated_protein_kinase_9" title="Mitogen-activated protein kinase 9">MAPK9</a></li> <li><a href="/wiki/MAPK10" title="MAPK10">MAPK10</a></li></ul></li> <li><a href="/wiki/P38_mitogen-activated_protein_kinases" title="P38 mitogen-activated protein kinases">P38 mitogen-activated protein</a> <ul><li><a href="/wiki/MAPK11" title="MAPK11">MAPK11</a></li> <li><a href="/wiki/MAPK13" title="MAPK13">MAPK13</a></li> <li><a href="/wiki/MAPK14" title="MAPK14">MAPK14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MAP_kinase_kinase_kinase" title="MAP kinase kinase kinase">MAP3K</a> (EC 2.7.11.25)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MAP_kinase_kinase_kinase" title="MAP kinase kinase kinase">MAP kinase kinase kinases</a> <ul><li><a href="/wiki/MAP3K1" title="MAP3K1">MAP3K1</a></li> <li><a href="/wiki/MAP3K2" title="MAP3K2">MAP3K2</a></li> <li><a href="/wiki/MAP3K3" title="MAP3K3">MAP3K3</a></li> <li><a href="/wiki/MAP3K4" title="MAP3K4">MAP3K4</a></li> <li><a href="/wiki/ASK1" title="ASK1">MAP3K5</a></li> <li><a href="/w/index.php?title=MAP3K6&action=edit&redlink=1" class="new" title="MAP3K6 (page does not exist)">MAP3K6</a></li> <li><a href="/wiki/MAP3K7" title="MAP3K7">MAP3K7</a></li> <li><a href="/wiki/MAP3K8" title="MAP3K8">MAP3K8</a></li></ul></li> <li><a href="/wiki/C-Raf" title="C-Raf">RAFs</a> <ul><li><a href="/wiki/ARAF" title="ARAF">ARAF</a></li> <li><a href="/wiki/BRAF_(gene)" title="BRAF (gene)">BRAF</a></li> <li><a href="/wiki/KSR1" title="KSR1">KSR1</a></li> <li><a href="/wiki/KSR2" title="KSR2">KSR2</a></li></ul></li> <li><a href="/w/index.php?title=MLK_(kinase)&action=edit&redlink=1" class="new" title="MLK (kinase) (page does not exist)">MLKs</a> <ul><li><a href="/wiki/MAP3K12" title="MAP3K12">MAP3K12</a></li> <li><a href="/wiki/MAP3K13" title="MAP3K13">MAP3K13</a></li> <li><a href="/wiki/MAP3K9" title="MAP3K9">MAP3K9</a></li> <li><a href="/wiki/MAP3K10" title="MAP3K10">MAP3K10</a></li> <li><a href="/wiki/MAP3K11" title="MAP3K11">MAP3K11</a></li> <li><a href="/wiki/MAP3K7" title="MAP3K7">MAP3K7</a></li> <li><a href="/wiki/ZAK" title="ZAK">ZAK</a></li></ul></li> <li><a href="/wiki/Cell_division_cycle_7-related_protein_kinase" title="Cell division cycle 7-related protein kinase">CDC7</a></li> <li><a href="/wiki/MAP3K14" title="MAP3K14">MAP3K14</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tau-protein_kinase" title="Tau-protein kinase">Tau-protein kinase</a> (EC 2.7.11.26)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TPK1" title="TPK1">TPK1</a></li> <li><a href="/wiki/TTK_(gene)" title="TTK (gene)">TTK</a></li> <li><a href="/wiki/GSK-3" title="GSK-3">GSK-3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/(acetyl-CoA_carboxylase)_kinase" title="(acetyl-CoA carboxylase) kinase">(acetyl-CoA carboxylase) kinase</a> (EC 2.7.11.27)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tropomyosin_kinase" title="Tropomyosin kinase">Tropomyosin kinase</a> (EC 2.7.11.28)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Low-density-lipoprotein_receptor_kinase" title="Low-density-lipoprotein receptor kinase">Low-density-lipoprotein receptor kinase</a> (EC 2.7.11.29)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>-</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_protein_serine/threonine_kinase" title="Receptor protein serine/threonine kinase">Receptor protein serine/threonine kinase</a> (EC 2.7.11.30)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bone_morphogenetic_protein_receptors" class="mw-redirect" title="Bone morphogenetic protein receptors">Bone morphogenetic protein receptors</a> <ul><li><a href="/wiki/Bone_morphogenetic_protein_receptor,_type_1" title="Bone morphogenetic protein receptor, type 1">BMPR1</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">BMPR1A</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">BMPR1B</a></li> <li><a href="/wiki/BMPR2" title="BMPR2">BMPR2</a></li></ul></li> <li><a href="/wiki/ACVR1" title="ACVR1">ACVR1</a></li> <li><a href="/wiki/ACVR1B" title="ACVR1B">ACVR1B</a></li> <li><a href="/wiki/ACVR1C" title="ACVR1C">ACVR1C</a></li> <li><a href="/wiki/ACVR2A" title="ACVR2A">ACVR2A</a></li> <li><a class="mw-selflink selflink">ACVR2B</a></li> <li><a href="/wiki/ACVRL1" title="ACVRL1">ACVRL1</a></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone_receptor" title="Anti-Müllerian hormone receptor">Anti-Müllerian hormone receptor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Dual-specificity_kinases_(EC_2.7.12)" style="font-size:114%;margin:0 4em"><a href="/wiki/Dual-specificity_kinase" title="Dual-specificity kinase">Dual-specificity kinases</a> (EC 2.7.12)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="MAP2K" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitogen-activated_protein_kinase_kinase" title="Mitogen-activated protein kinase kinase">MAP2K</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MAP2K1" title="MAP2K1">MAP2K1</a></li> <li><a href="/wiki/MAP2K2" title="MAP2K2">MAP2K2</a></li> <li><a href="/wiki/MAP2K3" title="MAP2K3">MAP2K3</a></li> <li><a href="/wiki/MAP2K4" title="MAP2K4">MAP2K4</a></li> <li><a href="/wiki/MAP2K5" title="MAP2K5">MAP2K5</a></li> <li><a href="/wiki/MAP2K6" title="MAP2K6">MAP2K6</a></li> <li><a href="/wiki/MAP2K7" title="MAP2K7">MAP2K7</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="TGFβ_receptor_superfamily_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:TGF%CE%B2_receptor_superfamily_modulators" title="Template talk:TGFβ receptor superfamily modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Special:EditPage/Template:TGFβ receptor superfamily modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="TGFβ_receptor_superfamily_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/TGF%CE%B2_receptor_superfamily" class="mw-redirect" title="TGFβ receptor superfamily"><abbr title="Transforming growth factor beta">TGFβ</abbr> receptor superfamily</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_I" class="mw-redirect" title="TGFβ superfamily receptor">Type I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK1" class="mw-redirect" title="ALK1"><abbr title="Activin receptor-like kinase 1">ALK1</abbr> (<abbr title="Activin A receptor-like type 1">ACVRL1</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/BMP10" class="mw-redirect" title="BMP10">10</a>)</li> <li><a href="/w/index.php?title=Cetermin&action=edit&redlink=1" class="new" title="Cetermin (page does not exist)">Cetermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF2" title="GDF2">2 (BMP9)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ascrinvacumab" title="Ascrinvacumab">Ascrinvacumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li> <li><a href="/w/index.php?title=ML-347&action=edit&redlink=1" class="new" title="ML-347 (page does not exist)">ML-347 (LDN-193719, VU0469381)</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Dalantercept" class="mw-redirect" title="Dalantercept">Dalantercept</a></li></ul> <ul><li><i>Other inhibitors:</i> <a href="/w/index.php?title=Disitertide&action=edit&redlink=1" class="new" title="Disitertide (page does not exist)">Disitertide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK2" class="mw-redirect" title="ALK2"><abbr title="Activin receptor-like kinase 2">ALK2</abbr> (<abbr title="Activin A receptor type 1A">ACVR1A</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li> <li><a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>)</li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-1&action=edit&redlink=1" class="new" title="DMH-1 (page does not exist)">DMH-1</a></li> <li><a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li> <li><a href="/w/index.php?title=ML-347&action=edit&redlink=1" class="new" title="ML-347 (page does not exist)">ML-347 (LDN-193719, VU0469381)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK3" class="mw-redirect" title="ALK3"><abbr title="Activin receptor-like kinase 3">ALK3</abbr> (<abbr title="Bone morphogenetic protein receptor type 1A">BMPR1A</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK4" class="mw-redirect" title="ALK4"><abbr title="Activin receptor-like kinase 4">ALK4</abbr> (<abbr title="Activin A receptor type 1B">ACVR1B</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK5" class="mw-redirect" title="ALK5"><abbr title="Activin receptor-like kinase 5">ALK5</abbr> (<abbr title="Transforming growth factor beta receptor 1">TGFβR1</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF10" title="GDF10">10 (BMP3B)</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/w/index.php?title=D-4476&action=edit&redlink=1" class="new" title="D-4476 (page does not exist)">D-4476</a></li> <li><a href="/w/index.php?title=GW-788388&action=edit&redlink=1" class="new" title="GW-788388 (page does not exist)">GW-788388</a></li> <li><a href="/w/index.php?title=LY-364947&action=edit&redlink=1" class="new" title="LY-364947 (page does not exist)">LY-364947</a></li> <li><a href="/wiki/LY-2109761" title="LY-2109761">LY-2109761</a></li> <li><a href="/wiki/Galunisertib" title="Galunisertib">Galunisertib (LY-2157299)</a></li> <li><a href="/w/index.php?title=R-268712&action=edit&redlink=1" class="new" title="R-268712 (page does not exist)">R-268712</a></li> <li><a href="/wiki/RepSox" title="RepSox">RepSox (E-616452, SJN-2511)</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li> <li><a href="/w/index.php?title=SB-525334&action=edit&redlink=1" class="new" title="SB-525334 (page does not exist)">SB-525334</a></li> <li><a href="/w/index.php?title=SD-208&action=edit&redlink=1" class="new" title="SD-208 (page does not exist)">SD-208</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK6" class="mw-redirect" title="ALK6"><abbr title="Activin receptor-like kinase 6">ALK6</abbr> (<abbr title="Bone morphogenetic protein receptor type 1B">BMPR1B</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>, <a href="/wiki/BMP15" class="mw-redirect" title="BMP15">15 (GDF9B)</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>, <a href="/wiki/GDF9" class="mw-redirect" title="GDF9">9</a>, <a href="/wiki/GDF15" title="GDF15">15</a>)</li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK7" class="mw-redirect" title="ALK7"><abbr title="Activin receptor-like kinase 7">ALK7</abbr> (<abbr title="Activin A receptor type 1C">ACVR1C</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_II" class="mw-redirect" title="TGFβ superfamily receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/TGF%CE%B2R2" class="mw-redirect" title="TGFβR2"><abbr title="Transforming growth factor beta receptor 2">TGFβR2</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF10" title="GDF10">10 (BMP3B)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=LY-364947&action=edit&redlink=1" class="new" title="LY-364947 (page does not exist)">LY-364947</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/BMPR2" title="BMPR2"><abbr title="Bone morphogenetic protein receptor type 2">BMPR2</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP10" class="mw-redirect" title="BMP10">10</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF2" title="GDF2">2 (BMP9)</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>)</li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ACVR2A" title="ACVR2A"><abbr title="Activin receptor type 2A">ACVR2A</abbr> (<abbr title="Activin receptor type 2">ACVR2</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>, <a href="/wiki/BMP15" class="mw-redirect" title="BMP15">15 (GDF9B)</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>, <a href="/wiki/GDF9" class="mw-redirect" title="GDF9">9</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>, <a href="/wiki/GDF15" title="GDF15">15</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Sotatercept" title="Sotatercept">Sotatercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ACVR2A" title="ACVR2A"><abbr title="Activin receptor type 2B">ACVR2B</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_3" title="Bone morphogenetic protein 3">Osteogenin (BMP3, BMP3A)</a></li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=Ramatercept&action=edit&redlink=1" class="new" title="Ramatercept (page does not exist)">Ramatercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/AMHR2" class="mw-redirect" title="AMHR2"><abbr title="Anti-Müllerian hormone receptor type 2">AMHR2</abbr> (<abbr title="Anti-Müllerian hormone receptor">AMHR</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_III" class="mw-redirect" title="TGFβ superfamily receptor">Type III</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TGFβR3_(β-glycan)" scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/TGF%CE%B2R3" class="mw-redirect" title="TGFβR3"><abbr title="Transforming growth factor beta receptor 3">TGFβR3</abbr> (β-glycan)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Ligands:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Endogenous antagonists/inhibitors:</i> <a href="/wiki/BAMBI" title="BAMBI">BAMBI</a></li> <li><a href="/wiki/Cerberus_(protein)" title="Cerberus (protein)">Cerberus (CER1)</a></li> <li><a href="/wiki/Chordin" title="Chordin">Chordin</a></li> <li><a href="/wiki/DAN_(protein)" class="mw-redirect" title="DAN (protein)">DAN (PARN)</a></li> <li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Follistatin" title="Follistatin">Follistatin</a></li> <li><a href="/wiki/Gremlin_(protein)" title="Gremlin (protein)">Gremlin (Drm)</a></li> <li><a href="/wiki/LTBP1_(gene)" title="LTBP1 (gene)">LTBP1</a></li> <li><a href="/wiki/Noggin_(protein)" title="Noggin (protein)">Noggin</a></li> <li><a href="/wiki/Transforming_growth_interacting_factor" title="Transforming growth interacting factor">TGIF</a></li> <li><a href="/wiki/Thrombospondin_1" title="Thrombospondin 1">Thrombospondin 1 (THBS1)</a></li> <li><a href="/w/index.php?title=Tomoregulin_1&action=edit&redlink=1" class="new" title="Tomoregulin 1 (page does not exist)">Tomoregulin 1</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Stamulumab" title="Stamulumab">Stamulumab</a> (against myostatin)</li> <li><a href="/wiki/TRC105" class="mw-redirect" title="TRC105">TRC105</a> (against endoglin)</li></ul> <ul><li><i>Others:</i> <a href="/wiki/Endoglin" title="Endoglin">Endoglin</a></li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 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class="mw-file-description"><img alt="Stub icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/DNA_stub.svg/40px-DNA_stub.svg.png" decoding="async" width="40" height="30" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/DNA_stub.svg/60px-DNA_stub.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e2/DNA_stub.svg/80px-DNA_stub.svg.png 2x" data-file-width="816" data-file-height="621" /></a></span></td><td><p class="asbox-body">This article on a <a href="/wiki/Gene" title="Gene">gene</a> on human <a href="/wiki/Chromosome_3" title="Chromosome 3">chromosome 3</a> is a <a href="/wiki/Wikipedia:Stub" title="Wikipedia:Stub">stub</a>. 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