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Bruxelles</span></a></span><h1 class="u-m0x u-fw300 u-fs24 u-displayInline">CHU Brugmann - Endocrinology</h1></div><div class="u-floatRight u-mt1x"></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline"><li class="u-floatLeft u-pr5x u-mr5x u-borderColorGrayLight u-borderRight1"><a href="https://ulb.academia.edu/"><span><i class="fa fa-arrow-left"></i>  All Departments</span></a></li><li class="u-floatLeft active"><a href="https://ulb.academia.edu/Departments/CHU_Brugmann_Endocrinology/Documents">35 Papers</a></li><li class="u-floatLeft"><a href="https://ulb.academia.edu/Departments/CHU_Brugmann_Endocrinology">2 Researchers</a></li></ul></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="u-ph0x"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49184653" data-work_id="49184653" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49184653/%C3%80_quand_l_accr%C3%A9ditation_%C3%A0_Bruxelles_et_en_Wallonie_L_accr%C3%A9ditation_des_h%C3%B4pitaux_pour_assurer_un_fonctionnement_de_qualit%C3%A9">À quand l’accréditation à Bruxelles et en Wallonie?: L’accréditation des hôpitaux pour assurer un fonctionnement de qualité</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Il y a unanimité pour dire qu'accréditer les hôpitaux participe à leur régulation et donc par ce fait favorise le bon fonctionnement du système de soins de santé.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a 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fa-spin"></i></span><script>$(function () { var workId = 49184653; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=49184653]").text(description); $(".js-view-count-work_49184653").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49184653").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_84968039" data-work_id="84968039" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/84968039/Blood_anions_and_electrolytes_during_ritodrine_infusion_in_preterm_labor">Blood anions and electrolytes during ritodrine infusion in preterm labor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Seven patients with threatened premature labor and six nonpregnant female control subjects were studied for 12 to 24 hours during ritodrine infusion in order to re-evaluate the effects of this beta-adrenergic tocolytic agent on blood... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_84968039" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Seven patients with threatened premature labor and six nonpregnant female control subjects were studied for 12 to 24 hours during ritodrine infusion in order to re-evaluate the effects of this beta-adrenergic tocolytic agent on blood anions, electrolytes, and acid-base balance. Dexamethasone was given intramuscularly in all patients and three control subjects at the beginning of ritodrine infusion. Lactate, pyruvate, betahydroxybutyrate, sodium, potassium, chloride, bicarbonate, pH, glucose, and insulin levels were measured in blood samples obtained at intervals of 2 to 6 hours. While pH remained in the normal range, increases in lactate and pyruvate levels and decreases in bicarbonate values resulted in a significant increase in anion gap 4 to 6 hours after the beginning of treatment. The blood potassium level fell simultaneously. These effects were transient, lasting less than 10 hours, despite continuation of ritodrine infusion and maintenance of tocolysis and tachycardia. Although larger increases in the blood glucose level were observed with combined therapy in control subjects, dexamethasone had no additional influence on potassium concentrations. Monitoring of patients treated by intravenous ritodrine should include routine measurements of blood glucose and electrolyte levels in order to detect its potentiaHy harmful metabolic side effects for mother and fetus. 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Dexamethasone was given intramuscularly in all patients and three control subjects at the beginning of ritodrine infusion. Lactate, pyruvate, betahydroxybutyrate, sodium, potassium, chloride, bicarbonate, pH, glucose, and insulin levels were measured in blood samples obtained at intervals of 2 to 6 hours. While pH remained in the normal range, increases in lactate and pyruvate levels and decreases in bicarbonate values resulted in a significant increase in anion gap 4 to 6 hours after the beginning of treatment. The blood potassium level fell simultaneously. These effects were transient, lasting less than 10 hours, despite continuation of ritodrine infusion and maintenance of tocolysis and tachycardia. Although larger increases in the blood glucose level were observed with combined therapy in control subjects, dexamethasone had no additional influence on potassium concentrations. Monitoring of patients treated by intravenous ritodrine should include routine measurements of blood glucose and electrolyte levels in order to detect its potentiaHy harmful metabolic side effects for mother and fetus. 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Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}],"research_interests":[{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"},{"id":1256814,"name":"Architecture Hospitalière","url":"https://www.academia.edu/Documents/in/Architecture_Hospitaliere"}],"publication_year":2013,"publication_year_with_fallback":2013,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_84968619" data-work_id="84968619" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/84968619/Les_d%C3%A9fis_de_la_complexit%C3%A9">Les défis de la complexité</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">En la tesis realizada se aborda la problemática de la Relación con el Saber, en una situación grupal correspondiente al escenario de la Educación Superior de nuestro país. Se describen los antecedentes y el estado actual del arte sobre la... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_84968619" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">En la tesis realizada se aborda la problemática de la Relación con el Saber, en una situación grupal correspondiente al escenario de la Educación Superior de nuestro país. Se describen los antecedentes y el estado actual del arte sobre la problemática investigada en tres países: Francia, Argentina y Uruguay. El objeto de estudio en el plano epistemológico es definido desde la complejidad. El mismo es abordado a nivel teórico y metodológico desde la complementariedad multirreferencial. Dicho abordaje teórico implica la integración de nociones de distintos campos disciplinarios: psicoanálisis, educación, psicología de los grupos, psicopedagogía, socioanálisis y didáctica. La metodología diseñada de investigación</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/84968619" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="675ba29ddb192cd03f12c4f5dcd6513b" rel="nofollow" data-download="{"attachment_id":89814333,"asset_id":84968619,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/89814333/download_file?st=MTc0MzA1NTY2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_84968619 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="84968619"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 84968619, container: ".js-paper-rank-work_84968619", }); });</script></li><li class="js-percentile-work_84968619 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84968619; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_84968619"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_84968619 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="84968619"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84968619; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84968619]").text(description); $(".js-view-count-work_84968619").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_84968619").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_84968662" data-work_id="84968662" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/84968662/Turbulences_hospitali%C3%A8res_Outre_Mer">Turbulences hospitalières Outre Mer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">O presente artigo busca discutir duas categorias psiquiátricas, delírios e alucinações, tradicionalmente descritas como sintomas de transtorno psicótico, com o conceito de comportamento orientado pelo behaviorismo radical de B. F.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_84968662" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">O presente artigo busca discutir duas categorias psiquiátricas, delírios e alucinações, tradicionalmente descritas como sintomas de transtorno psicótico, com o conceito de comportamento orientado pelo behaviorismo radical de B. F. Skinner. O artigo inicia com a visão da Associação Americana de Psiquiatria, a qual procura descrever essas categorias como sintomas positivos de esquizofrenia e suas repercussões. Uma abordagem funcionalista para os comportamentos de delirar e alucinar são consideradas em alguns importantes detalhes. Os conceitos de visão e audição condicionada são discutidos como experiência comum. Finalmente, considerações são dadas para as implicações dos efeitos desses tipos de comportamentos-problema e sugestões para lidar com eventos dessa natureza no contexto clínico são oferecidas.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/84968662" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7229c8246e18ba83f2970ad478e238b7" rel="nofollow" data-download="{"attachment_id":89814356,"asset_id":84968662,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/89814356/download_file?st=MTc0MzA1NTY2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_84968662 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="84968662"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 84968662, container: ".js-paper-rank-work_84968662", }); });</script></li><li class="js-percentile-work_84968662 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 84968662; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_84968662"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_84968662 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="84968662"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 84968662; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=84968662]").text(description); $(".js-view-count-work_84968662").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_84968662").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_93056537" data-work_id="93056537" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/93056537/Symptomatic_hypopituitarism_revealing_primary_suprasellar_lymphoma">Symptomatic hypopituitarism revealing primary suprasellar lymphoma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The most common cause of hypopituitarism is pituitary adenoma. However, in the case of suprasellar masses different etiologies are possible. We report an unusual case of primary suprasellar lymphoma presented with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_93056537" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The most common cause of hypopituitarism is pituitary adenoma. However, in the case of suprasellar masses different etiologies are possible. We report an unusual case of primary suprasellar lymphoma presented with hypopituitarism. Case presentation: A 26 year old woman presented with amenorrhea, galactorrhea and neurological disorders. Also, the laboratory work-up revealed partial hypopituitarism. The magnetic resonance imaging of the head showed a suprasellar mass. A presumptive diagnosis of granulomatous processes was made and the patient was given steroid therapy. Repeated brain MRI detected new lesions in the brain with regression of the suprasellar mass. Stereotactic biopsy of the paraventricular lesion revealed the diagnosis of B-cell lymphoma. Conclusion: This case presentation reports a rare cause of hypopituitarism. Primary suprasellar lymphoma is extremely rare and represented a real diagnostic challenge. Besides, suprasellar masses are varied in aetiology and can present diagnostic problems for a radiologist. Also, because of the increased incidence of PCNSL, lymphoma must be kept in mind in the differential diagnosis of lesions in the suprasellar region.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/93056537" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="27608dc5c526d04b01e76b546e7f09de" rel="nofollow" data-download="{"attachment_id":95900662,"asset_id":93056537,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/95900662/download_file?st=MTc0MzA1NTY2OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_93056537 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="93056537"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 93056537, container: ".js-paper-rank-work_93056537", }); 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However, in the case of suprasellar masses different etiologies are possible. We report an unusual case of primary suprasellar lymphoma presented with hypopituitarism. Case presentation: A 26 year old woman presented with amenorrhea, galactorrhea and neurological disorders. Also, the laboratory work-up revealed partial hypopituitarism. The magnetic resonance imaging of the head showed a suprasellar mass. A presumptive diagnosis of granulomatous processes was made and the patient was given steroid therapy. Repeated brain MRI detected new lesions in the brain with regression of the suprasellar mass. Stereotactic biopsy of the paraventricular lesion revealed the diagnosis of B-cell lymphoma. Conclusion: This case presentation reports a rare cause of hypopituitarism. Primary suprasellar lymphoma is extremely rare and represented a real diagnostic challenge. Besides, suprasellar masses are varied in aetiology and can present diagnostic problems for a radiologist. 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episodic variations of adrenal androgens secretion in man</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_93056573" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r > 0.75; p< 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r>0.30; p<0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r > 0.30; P < 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/93056573" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="975540beaae94baaf7102abd752e66a6" rel="nofollow" data-download="{"attachment_id":95900683,"asset_id":93056573,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/95900683/download_file?st=MTc0MzA1NTY2OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_93056573 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="93056573"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 93056573, container: ".js-paper-rank-work_93056573", }); 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The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r \u003e 0.75; p\u003c 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r\u003e0.30; p\u003c0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r \u003e 0.30; P \u003c 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.","publication":"Journal of Endocrinological Investigation","publication_with_fallback":"Journal of Endocrinological 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u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/94052703/Regression_of_lung_size_in_adults_with_growth_hormone_deficiency">Regression of lung size in adults with growth hormone deficiency</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pulmonary function was investigated in eight patients with hypopituitarism to determine if the lung is affected by the generalized visceral atrophy of hypopituitarism; six patients with acromegaly and trophic hormone deficiencies were... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_94052703" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pulmonary function was investigated in eight patients with hypopituitarism to determine if the lung is affected by the generalized visceral atrophy of hypopituitarism; six patients with acromegaly and trophic hormone deficiencies were studied for comparison. The patients with hypopituitarism, including one with isolated growth hormone (GH) deficiency, had a restrictive type of ventilatory impairment (total lung capacity was 76.7 +/- 4.7 per cent of predicted, p less than 0.005) which was not influenced by cortisone, thyroxine, or sex hormone replacement therapy. In contrast, the patients with acromegaly, despite deficiency of one or more pituitary hormones, had larger lungs than controls (total lung capacity was 119.5 +/- 5.0 per cent of predicted, p less than 0.01). These findings indicate that GH influences the lung volume in adult man and that the loss of GH secretion is likely to be responsible for the restrictive ventilatory impairment associated with hypopituitarism. Further studies showed that this restrictive defect was not related to neuromuscular impairment or to an abnormality of chest wall mechanics and suggested that the ventilated air spaces retained normal elastic properties. A decrease in lung size occurs in patients who develop GH deficiency. Thus, normal levels of GH are necessary for maintaining normal lung size during adult life.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/94052703" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a15d984194b186c2a43be2b58e340613" rel="nofollow" data-download="{"attachment_id":104884305,"asset_id":94052703,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/104884305/download_file?st=MTc0MzA1NTY2OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_94052703 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="94052703"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 94052703, container: ".js-paper-rank-work_94052703", }); 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creuset pour l’enseignement clinique et la recherche médicale dans les deux universités (ULB et VUB) auxquelles il est associé. Le nom de médecins illustres, créatifs et novateurs... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_105407210" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Depuis sa création en 1923, le CHU Brugmann constitue un creuset pour l’enseignement clinique et la recherche médicale dans les deux universités (ULB et VUB) auxquelles il est associé. Le nom de médecins illustres,<br />créatifs et novateurs est attaché de longue date à l’hôpital : Antoine Depage a été l’un des pères de la chirurgie moderne, en temps de paix comme en temps de guerre, et le fondateur du premier centre des tumeurs de l’ULB ; Albert Hustin a révolutionné la transfusion sanguine ; élève de Paul Govaerts, Pierre-Paul Lambert a défriché la physiopathologie rénale et préparé l’ère de l’hémodialyse et de la transplantation du rein ; Willy Gepts a été le premier à apporter la preuve<br />histologique de l’étiologie auto-immune du diabète sucré de type 1 ; Jean- Pierre Naets a contribué à élucider le rôle de l’érythropoïétine (EPO) ; ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/105407210" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="21d98934d2b438dc90c0ba16bf528dce" rel="nofollow" data-download="{"attachment_id":104869346,"asset_id":105407210,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/104869346/download_file?st=MTc0MzA1NTY2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-105407210">+1</span><div class="hidden js-additional-users-105407210"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/OlivierVermylen">Olivier Vermylen</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-105407210'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-105407210').html(); 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container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_105407210 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="105407210"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 105407210; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=105407210]").text(description); $(".js-view-count-work_105407210").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_105407210").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_105412715 coauthored" data-work_id="105412715" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/105412715/Lendocrinologie_le_m%C3%A9tabolisme_phospho_calcique_lost%C3%A9oporose_et_l%C3%A9tude_FRISBEE_au_CHU_Brugmann">L'endocrinologie, le métabolisme phospho-calcique, l'ostéoporose et l'étude FRISBEE au CHU Brugmann</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cet article résume l’évolution de l’endocrinologie et des études du métabolisme phospho-calcique au CHU Brugmann (Bruxelles) depuis les années cinquante jusqu’à nos jours. L’importance de l’ostéoporose est rappelée, tant en termes de... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_105412715" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cet article résume l’évolution de l’endocrinologie et des études du métabolisme phospho-calcique au CHU Brugmann (Bruxelles) depuis les années cinquante jusqu’à nos jours. L’importance de l’ostéoporose est rappelée, tant en termes de morbidité et de mortalité accrues, que de coûts pour la santé publique.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/105412715" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="270729c18f8a8133bff0b126566470d1" rel="nofollow" data-download="{"attachment_id":104874717,"asset_id":105412715,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/104874717/download_file?st=MTc0MzA1NTY2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-105412715">+1</span><div class="hidden js-additional-users-105412715"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/LauraIconaru">Laura Iconaru</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-105412715'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-105412715').html(); 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Édifiée au début du XXe siècle in the middle of nowhere dans la petite ville de Rochester (80.000 habitants aujourd'hui), la Mayo Clinic était au... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_105424151" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">La Mayo Clinic est une institution académique américaine de référence, réputée et atypique. Édifiée au début du XXe siècle in the middle of nowhere dans la petite ville de Rochester (80.000 habitants aujourd'hui), la Mayo Clinic était au départ une simple polyclinique pratiquant la<br />médecine de groupe. Elle a successivement absorbé au sein de la Mayo Foundation les deux principaux hôpitaux de Rochester, et une série de polycliniques dans le Middle West (Minnesota, Iowa, Wisconsin). Elle s'est ensuite diversifiée à partir de 1986, en s'implantant à deux reprises à<br />2.000 km de là (à Jacksonville en Floride, et à Scottsville en Arizona), dans des régions à forte densité de pensionnés, donc de patients potentiels.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/105424151" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8c910566116da608cfbd833d7f03f9b2" rel="nofollow" data-download="{"attachment_id":104883171,"asset_id":105424151,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/104883171/download_file?st=MTc0MzA1NTY2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_105424151 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="105424151"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 105424151, container: ".js-paper-rank-work_105424151", }); 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Subsequent hormonal investigations demonstrated a failure of all anterior pituitary functions. Pneumotomo-encephalography revealed... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_117462449" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A 64-year-old nulliparous woman presented with clinical signs of thyroid and adrenocortical insufficiency. Subsequent hormonal investigations demonstrated a failure of all anterior pituitary functions. Pneumotomo-encephalography revealed a large arachnoid herniation, leading to the diagnosis of primary empty sella turcica syndrome with secondary panhypopituitarism. This unusual observation emphasizes the necessity of ruling out an empty sella turcica syndrome in patients with pituitary insufficiency.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/117462449" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="35249fea82d31df0453d4a038991bd9d" rel="nofollow" data-download="{"attachment_id":113313246,"asset_id":117462449,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/113313246/download_file?st=MTc0MzA1NTY2OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_117462449 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="117462449"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 117462449, container: ".js-paper-rank-work_117462449", }); 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u-pv7x u-mb0x js-work-card work_117462459" data-work_id="117462459" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/117462459/Control_of_circadian_and_episodic_variations_of_adrenal_androgens_secretion_in_man">Control of circadian and episodic variations of adrenal androgens' secretion in man</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_117462459" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r > 0.75; p< 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r>0.30; p<0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r > 0.30; P < 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/117462459" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6eac21c3a0a8027425191de356cdb4ab" rel="nofollow" data-download="{"attachment_id":113313250,"asset_id":117462459,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/113313250/download_file?st=MTc0MzA1NTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="70952271" href="https://ulb.academia.edu/DanielDesir">Daniel Desir</a><script data-card-contents-for-user="70952271" type="text/json">{"id":70952271,"first_name":"Daniel","last_name":"Desir","domain_name":"ulb","page_name":"DanielDesir","display_name":"Daniel Desir","profile_url":"https://ulb.academia.edu/DanielDesir","photo":"https://0.academia-photos.com/70952271/36814488/77112238/s65_daniel.desir.jpg"}</script></span></span></li><li class="js-paper-rank-work_117462459 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="117462459"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 117462459, container: ".js-paper-rank-work_117462459", }); 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The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r \u003e 0.75; p\u003c 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r\u003e0.30; p\u003c0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r \u003e 0.30; P \u003c 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.","publication":"Acta Clinica Belgica","publication_with_fallback":"Acta Clinica 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