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class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Université Libre de Bruxelles (MD 1974, PhD 1982)Board certified in Internal Medicine<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><h3 class="ds2-5-heading-sans-serif-xs">Related Authors</h3></div><ul class="suggested-user-card-list" data-nosnippet="true"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://unizg.academia.edu/AndrejDujella"><img class="profile-avatar u-positionAbsolute" alt="Andrej Dujella related author profile picture" 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src="https://0.academia-photos.com/191329/90380/6936137/s200_kevin.arbuckle.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://swansea.academia.edu/KevinArbuckle">Kevin Arbuckle</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Swansea University</p></div></div></ul></div><style type="text/css">.suggested-academics--header h3{font-size:16px;font-weight:500;line-height:20px}</style><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li><a class="ds2-5-text-link ds2-5-text-link--small" href="https://danieldesir1.academia.edu/"><span class="ds2-5-text-link__content"><i class="fa fa-laptop"></i></span></a></li><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Daniel Desir</h3></div><div class="js-work-strip profile--work_container" data-work-id="124378964"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124378964/Evolution_of_anterior_pituitary_functions_after_selective_removal_of_pituitary_microadenomas_in_Cushings_disease"><img alt="Research paper thumbnail of Evolution of anterior pituitary functions after selective removal of pituitary microadenomas in Cushing's disease" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evolution of anterior pituitary functions after selective removal of pituitary microadenomas in Cushing's disease</div><div class="wp-workCard_item"><span>European Journal of Clinical Investigation</span><span>, 1979</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378964"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378964"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378964; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124378964]").text(description); $(".js-view-count[data-work-id=124378964]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124378964; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124378964']"); 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{"id":124378964,"title":"Evolution of anterior pituitary functions after selective removal of pituitary microadenomas in Cushing's disease","translated_title":"","metadata":{"abstract":"SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":1979,"errors":{}},"publication_name":"European Journal of Clinical Investigation"},"translated_abstract":"SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe","internal_url":"https://www.academia.edu/124378964/Evolution_of_anterior_pituitary_functions_after_selective_removal_of_pituitary_microadenomas_in_Cushings_disease","translated_internal_url":"","created_at":"2024-10-03T01:14:24.496-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evolution_of_anterior_pituitary_functions_after_selective_removal_of_pituitary_microadenomas_in_Cushings_disease","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel 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data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124378963/La_r%C3%A9dorme_Obama_du_syst%C3%A8me_am%C3%A9ricain_de_soins_de_sant%C3%A9"><img alt="Research paper thumbnail of La rédorme Obama du système américain de soins de santé" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">La rédorme Obama du système américain de soins de santé</div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378963"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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santé","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/124378963/La_r%C3%A9dorme_Obama_du_syst%C3%A8me_am%C3%A9ricain_de_soins_de_sant%C3%A9","translated_internal_url":"","created_at":"2024-10-03T01:14:24.341-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"La_rédorme_Obama_du_système_américain_de_soins_de_santé","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","summary":null,"impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378963-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="124378962"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124378962/Residual_effects_of_a_short_term_intensified_insulin_therapy_in_type_2_diabetic_patients_with_oral_drug_failure"><img alt="Research paper thumbnail of Residual effects of a short-term intensified insulin therapy in type 2 diabetic patients with oral drug failure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Residual effects of a short-term intensified insulin therapy in type 2 diabetic patients with oral drug failure</div><div class="wp-workCard_item"><span>Diabète & métabolisme</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study was designed to evaluate the long-term effects of a short course of insulin the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study was designed to evaluate the long-term effects of a short course of insulin therapy on glycaemic control in type 2 diabetic patients after failure with oral therapy. Twenty type 2 diabetic patients poorly controlled with maximal doses of sulfonylurea were given intensified insulin treatment for 12-14 days adjusted so as to achieve near normoglycaemia. They were then restarted on their previous oral medication to which one bedtime injection of NPH insulin was added if the mean diurnal glucose profile exceeded 10 mM (n = 8). At the follow up evaluation (n = 18), 6 +/- 1 months later, fasting glucose (12.3 +/- 1.1 to 8.3 +/- 0.6 mM) and HbA1c (10.2 +/- 0.5 to 8.5 +/- 0.5%) levels were significantly improved in the patients receiving a combined therapy. In the group maintained on sulfonylurea alone, fasting glucose (13.2 +/- 0.7 to 6.9 +/- 0.7 mM) and HbA1c (9.6 +/- 0.6 to 6.9 +/- 0.6%) were also significantly improved in 5 patients who had lost weight (-6 +/- 1 kg) wh...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378962"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378962"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378962; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124378962]").text(description); $(".js-view-count[data-work-id=124378962]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124378962; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124378962']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=124378962]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124378962,"title":"Residual effects of a short-term intensified insulin therapy in type 2 diabetic patients with oral drug failure","translated_title":"","metadata":{"abstract":"The present study was designed to evaluate the long-term effects of a short course of insulin therapy on glycaemic control in type 2 diabetic patients after failure with oral therapy. 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In the group maintained on sulfonylurea alone, fasting glucose (13.2 +/- 0.7 to 6.9 +/- 0.7 mM) and HbA1c (9.6 +/- 0.6 to 6.9 +/- 0.6%) were also significantly improved in 5 patients who had lost weight (-6 +/- 1 kg) wh...","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":453923,"name":"Oral Hypoglycemic Agents","url":"https://www.academia.edu/Documents/in/Oral_Hypoglycemic_Agents"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":593535,"name":"Sulfonylurea","url":"https://www.academia.edu/Documents/in/Sulfonylurea"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1569219,"name":"Médecine Interne","url":"https://www.academia.edu/Documents/in/Medecine_Interne"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3341854,"name":"Glipizide","url":"https://www.academia.edu/Documents/in/Glipizide"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378962-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="124378961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124378961/_100_years_at_the_Brugmann_Hospital_"><img alt="Research paper thumbnail of [100 years at the Brugmann Hospital]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">[100 years at the Brugmann Hospital]</div><div class="wp-workCard_item"><span>Revue médicale de Bruxelles</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378961; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124378961]").text(description); $(".js-view-count[data-work-id=124378961]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124378961; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124378961']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378961-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="124378958"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124378958/Triac_3_5_3_Triiodo_Thyroacetic_Acid_Induced_Pseudohypothyroidism_"><img alt="Research paper thumbnail of Triac (3,5,3’Triiodo-Thyroacetic Acid) Induced « Pseudohypothyroidism »" class="work-thumbnail" src="https://attachments.academia-assets.com/118616092/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124378958/Triac_3_5_3_Triiodo_Thyroacetic_Acid_Induced_Pseudohypothyroidism_">Triac (3,5,3’Triiodo-Thyroacetic Acid) Induced « Pseudohypothyroidism »</a></div><div class="wp-workCard_item"><span>Acta Clinica Belgica</span><span>, 1984</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5cb542a8fbbdb1f0694e932cabb10a2c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118616092,"asset_id":124378958,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118616092/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378958"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378958"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378958; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124378958]").text(description); $(".js-view-count[data-work-id=124378958]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124378958; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124378958']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462461-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462460/Hormonal_Changes_after_Jet_Lag_in_Normal_Man"><img alt="Research paper thumbnail of Hormonal Changes after Jet Lag in Normal Man" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Hormonal Changes after Jet Lag in Normal Man</div><div class="wp-workCard_item"><span>Advances in biological psychiatry</span><span>, Apr 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">info:eu-repo/semantics/publishe</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462460; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462460-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462459"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462459/Control_of_circadian_and_episodic_variations_of_adrenal_androgens_secretion_in_man"><img alt="Research paper thumbnail of Control of circadian and episodic variations of adrenal androgens' secretion in man" class="work-thumbnail" src="https://attachments.academia-assets.com/113313250/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462459/Control_of_circadian_and_episodic_variations_of_adrenal_androgens_secretion_in_man">Control of circadian and episodic variations of adrenal androgens' secretion in man</a></div><div class="wp-workCard_item"><span>Acta Clinica Belgica</span><span>, 1985</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r > 0.75; p< 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r>0.30; p<0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r > 0.30; P < 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f598e38b1cd11713fb431cac40552be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313250,"asset_id":117462459,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313250/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462459"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462459"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462459; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462459]").text(description); $(".js-view-count[data-work-id=117462459]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462459; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462459']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f598e38b1cd11713fb431cac40552be" } } $('.js-work-strip[data-work-id=117462459]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462459,"title":"Control of circadian and episodic variations of adrenal androgens' secretion in man","translated_title":"","metadata":{"publisher":"Maney Publishing","grobid_abstract":"The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). 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The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462459-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462458"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462458/Le_Service_dEndocrinologie"><img alt="Research paper thumbnail of Le Service d'Endocrinologie" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Le Service d'Endocrinologie</div><div class="wp-workCard_item"><span>Revue Médicale de Bruxelles</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">L&#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">L&#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidiennes, maladies hypothalamo-hypophysaires, surrenaliennes, gonadiques et parathyroidiennes, obesites, hypercholesterolemies et syndromes endocriniens paraneoplasiques. Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d&#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l&#39;axe thyreotrope chez l&#39;homme normal. Des etudes du jet lag ont permis d&#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. D&#39;autres travaux ont aborde la regulation du metabolisme des corps cetoniques, les rapports entre l&#39;etat nutritionnel et le metabolisme du glucose et divers aspects d&#39;immunodiabetologie.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462458"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462458"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462458; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462458]").text(description); $(".js-view-count[data-work-id=117462458]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462458; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462458']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462458]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462458,"title":"Le Service d'Endocrinologie","translated_title":"","metadata":{"abstract":"L\u0026#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidiennes, maladies hypothalamo-hypophysaires, surrenaliennes, gonadiques et parathyroidiennes, obesites, hypercholesterolemies et syndromes endocriniens paraneoplasiques. Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d\u0026#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l\u0026#39;axe thyreotrope chez l\u0026#39;homme normal. Des etudes du jet lag ont permis d\u0026#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. 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Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d\u0026#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l\u0026#39;axe thyreotrope chez l\u0026#39;homme normal. Des etudes du jet lag ont permis d\u0026#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. 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Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d\u0026#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l\u0026#39;axe thyreotrope chez l\u0026#39;homme normal. Des etudes du jet lag ont permis d\u0026#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462456-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462455/Hormonal_changes_as_a_consequence_of_jet_lag_corticotrophic_axis"><img alt="Research paper thumbnail of Hormonal changes as a consequence of jet lag: corticotrophic axis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Hormonal changes as a consequence of jet lag: corticotrophic axis</div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Five normal male volunteers were subjected to seven consecutive studies at 10-day intervals over ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Five normal male volunteers were subjected to seven consecutive studies at 10-day intervals over a total period of 10 weeks. The investigation comprised a basal study in Brussels, a westward 7-hour time shift to Chicago, three studies in Chicago, an eastward flight back to Brussels, and three studies in Brussels. During each study, blood was drawn at 15 min intervals for 25 hours. Plasma adrenocorticotrophic hormone (ACTH) and Cortisol were measured in each sample. No quantitative alterations of the adrenocortical secretion were caused by jet lag. In all subjects the temporal organization of ACTH and Cortisol secretion was disrupted by the time shifts for at least 11 days after the flights. A dissociation in the rapidity of the adaptation of the time of maximal secretion and of the quiescent period was observed. This suggests that the maximal and minimal secretory periods may be controlled by different mechanisms.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462455; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462455]").text(description); $(".js-view-count[data-work-id=117462455]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462455; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462455']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462455]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462455,"title":"Hormonal changes as a consequence of jet lag: corticotrophic axis","translated_title":"","metadata":{"abstract":"Five normal male volunteers were subjected to seven consecutive studies at 10-day intervals over a total period of 10 weeks. 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This suggests that the maximal and minimal secretory periods may be controlled by different mechanisms.","publication_date":{"day":null,"month":null,"year":1980,"errors":{}}},"translated_abstract":"Five normal male volunteers were subjected to seven consecutive studies at 10-day intervals over a total period of 10 weeks. The investigation comprised a basal study in Brussels, a westward 7-hour time shift to Chicago, three studies in Chicago, an eastward flight back to Brussels, and three studies in Brussels. During each study, blood was drawn at 15 min intervals for 25 hours. Plasma adrenocorticotrophic hormone (ACTH) and Cortisol were measured in each sample. No quantitative alterations of the adrenocortical secretion were caused by jet lag. In all subjects the temporal organization of ACTH and Cortisol secretion was disrupted by the time shifts for at least 11 days after the flights. A dissociation in the rapidity of the adaptation of the time of maximal secretion and of the quiescent period was observed. This suggests that the maximal and minimal secretory periods may be controlled by different mechanisms.","internal_url":"https://www.academia.edu/117462455/Hormonal_changes_as_a_consequence_of_jet_lag_corticotrophic_axis","translated_internal_url":"","created_at":"2024-04-13T23:45:19.391-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hormonal_changes_as_a_consequence_of_jet_lag_corticotrophic_axis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Five normal male volunteers were subjected to seven consecutive studies at 10-day intervals over a total period of 10 weeks. The investigation comprised a basal study in Brussels, a westward 7-hour time shift to Chicago, three studies in Chicago, an eastward flight back to Brussels, and three studies in Brussels. During each study, blood was drawn at 15 min intervals for 25 hours. Plasma adrenocorticotrophic hormone (ACTH) and Cortisol were measured in each sample. No quantitative alterations of the adrenocortical secretion were caused by jet lag. In all subjects the temporal organization of ACTH and Cortisol secretion was disrupted by the time shifts for at least 11 days after the flights. A dissociation in the rapidity of the adaptation of the time of maximal secretion and of the quiescent period was observed. This suggests that the maximal and minimal secretory periods may be controlled by different mechanisms.","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"}],"urls":[{"id":41076718,"url":"https://doi.org/10.1007/978-94-009-8709-8_24"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462455-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462454"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462454/La_Selle_Turcique_Vide_Une_Symptomatologie_Proteiforme"><img alt="Research paper thumbnail of La Selle Turcique Vide: Une Symptomatologie Proteiforme" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">La Selle Turcique Vide: Une Symptomatologie Proteiforme</div><div class="wp-workCard_item"><span>Acta Clinica Belgica</span><span>, 1981</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SummarySeven patients presenting an empty sella turcica are presented in this report. Pathogeneti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SummarySeven patients presenting an empty sella turcica are presented in this report. Pathogenetical, semeiological, diagnostic and therapeuticaJ features of this syndrome are reviewed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462454]").text(description); $(".js-view-count[data-work-id=117462454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462454,"title":"La Selle Turcique Vide: Une Symptomatologie Proteiforme","translated_title":"","metadata":{"abstract":"SummarySeven patients presenting an empty sella turcica are presented in this report. 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profile--work_container" data-work-id="117462453"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462453/Quantitative_analysis_of_spontaneous_variations_of_plasma_prolactin_in_normal_man"><img alt="Research paper thumbnail of Quantitative analysis of spontaneous variations of plasma prolactin in normal man" class="work-thumbnail" src="https://attachments.academia-assets.com/113313224/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462453/Quantitative_analysis_of_spontaneous_variations_of_plasma_prolactin_in_normal_man">Quantitative analysis of spontaneous variations of plasma prolactin in normal man</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-endocrinology and Metabolism</span><span>, Nov 1, 1981</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="466c71302533ed10c4632b98772b0019" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313224,"asset_id":117462453,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313224/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462453"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item 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src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">The Relationship between Episodic Variations of Plasma Prolactin and REM-Non-REM Cyclicity Is an Artifact*</div><div class="wp-workCard_item"><span>The Journal of Clinical Endocrinology and Metabolism</span><span>, 1982</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462452"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462452"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462452; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462452]").text(description); $(".js-view-count[data-work-id=117462452]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462452; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462452']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462452]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462452,"title":"The Relationship between Episodic Variations of Plasma Prolactin and REM-Non-REM Cyclicity Is an Artifact*","translated_title":"","metadata":{"abstract":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.","publisher":"Endocrine Society","publication_date":{"day":null,"month":null,"year":1982,"errors":{}},"publication_name":"The Journal of Clinical Endocrinology and Metabolism"},"translated_abstract":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.","internal_url":"https://www.academia.edu/117462452/The_Relationship_between_Episodic_Variations_of_Plasma_Prolactin_and_REM_Non_REM_Cyclicity_Is_an_Artifact_","translated_internal_url":"","created_at":"2024-04-13T23:45:18.719-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Relationship_between_Episodic_Variations_of_Plasma_Prolactin_and_REM_Non_REM_Cyclicity_Is_an_Artifact_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":64657,"name":"Prolactin","url":"https://www.academia.edu/Documents/in/Prolactin"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":592786,"name":"Rem Sleep","url":"https://www.academia.edu/Documents/in/Rem_Sleep"},{"id":1772810,"name":"Sleep Stages","url":"https://www.academia.edu/Documents/in/Sleep_Stages"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":41076715,"url":"https://doi.org/10.1210/jcem-54-1-70"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462452-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462451"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462451/Effects_of_Jet_Lag_on_Hormonal_Patterns_IV_Time_Shifts_Increase_Growth_Hormone_Release_"><img alt="Research paper thumbnail of Effects of “Jet Lag” on Hormonal Patterns. IV. Time Shifts Increase Growth Hormone Release*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Effects of “Jet Lag” on Hormonal Patterns. IV. Time Shifts Increase Growth Hormone Release*</div><div class="wp-workCard_item"><span>The Journal of Clinical Endocrinology and Metabolism</span><span>, Mar 1, 1983</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by &amp;quot;jet lag&amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462451"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462451"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462451; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462451]").text(description); $(".js-view-count[data-work-id=117462451]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462451; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462451']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462451]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462451,"title":"Effects of “Jet Lag” on Hormonal Patterns. IV. Time Shifts Increase Growth Hormone Release*","translated_title":"","metadata":{"abstract":"Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by \u0026amp;quot;jet lag\u0026amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","publisher":"Endocrine Society","publication_date":{"day":1,"month":3,"year":1983,"errors":{}},"publication_name":"The Journal of Clinical Endocrinology and Metabolism"},"translated_abstract":"Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by \u0026amp;quot;jet lag\u0026amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","internal_url":"https://www.academia.edu/117462451/Effects_of_Jet_Lag_on_Hormonal_Patterns_IV_Time_Shifts_Increase_Growth_Hormone_Release_","translated_internal_url":"","created_at":"2024-04-13T23:45:18.456-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_Jet_Lag_on_Hormonal_Patterns_IV_Time_Shifts_Increase_Growth_Hormone_Release_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by \u0026amp;quot;jet lag\u0026amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52562,"name":"Growth Hormone","url":"https://www.academia.edu/Documents/in/Growth_Hormone"},{"id":57928,"name":"Travel","url":"https://www.academia.edu/Documents/in/Travel"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":76423,"name":"Sleep Deprivation","url":"https://www.academia.edu/Documents/in/Sleep_Deprivation"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"},{"id":1772810,"name":"Sleep Stages","url":"https://www.academia.edu/Documents/in/Sleep_Stages"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":41076714,"url":"https://doi.org/10.1210/jcem-56-3-433"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462451-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462450"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462450/Quantitative_characterization_of_ACTH_and_adrenocortical_episodic_secretion_in_man_An_introduction"><img alt="Research paper thumbnail of Quantitative characterization of ACTH and adrenocortical episodic secretion in man: An introduction" class="work-thumbnail" src="https://attachments.academia-assets.com/113313248/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462450/Quantitative_characterization_of_ACTH_and_adrenocortical_episodic_secretion_in_man_An_introduction">Quantitative characterization of ACTH and adrenocortical episodic secretion in man: An introduction</a></div><div class="wp-workCard_item"><span>Journal of Steroid Biochemistry</span><span>, Jul 1, 1983</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6c333ea9e110aa6c2f43c2003fb0cff6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313248,"asset_id":117462450,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313248/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462450"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462450"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462450; 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In the group maintained on sulfonylurea alone, fasting glucose (13.2 +/- 0.7 to 6.9 +/- 0.7 mM) and HbA1c (9.6 +/- 0.6 to 6.9 +/- 0.6%) were also significantly improved in 5 patients who had lost weight (-6 +/- 1 kg) wh...","internal_url":"https://www.academia.edu/124378962/Residual_effects_of_a_short_term_intensified_insulin_therapy_in_type_2_diabetic_patients_with_oral_drug_failure","translated_internal_url":"","created_at":"2024-10-03T01:14:24.179-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Residual_effects_of_a_short_term_intensified_insulin_therapy_in_type_2_diabetic_patients_with_oral_drug_failure","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The present study was designed to evaluate the long-term effects of a short course of insulin therapy on glycaemic control in type 2 diabetic patients after failure with oral therapy. Twenty type 2 diabetic patients poorly controlled with maximal doses of sulfonylurea were given intensified insulin treatment for 12-14 days adjusted so as to achieve near normoglycaemia. They were then restarted on their previous oral medication to which one bedtime injection of NPH insulin was added if the mean diurnal glucose profile exceeded 10 mM (n = 8). At the follow up evaluation (n = 18), 6 +/- 1 months later, fasting glucose (12.3 +/- 1.1 to 8.3 +/- 0.6 mM) and HbA1c (10.2 +/- 0.5 to 8.5 +/- 0.5%) levels were significantly improved in the patients receiving a combined therapy. In the group maintained on sulfonylurea alone, fasting glucose (13.2 +/- 0.7 to 6.9 +/- 0.7 mM) and HbA1c (9.6 +/- 0.6 to 6.9 +/- 0.6%) were also significantly improved in 5 patients who had lost weight (-6 +/- 1 kg) wh...","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":453923,"name":"Oral Hypoglycemic Agents","url":"https://www.academia.edu/Documents/in/Oral_Hypoglycemic_Agents"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":593535,"name":"Sulfonylurea","url":"https://www.academia.edu/Documents/in/Sulfonylurea"},{"id":915951,"name":"Type 2 Diabetes Mellitus","url":"https://www.academia.edu/Documents/in/Type_2_Diabetes_Mellitus"},{"id":1569219,"name":"Médecine Interne","url":"https://www.academia.edu/Documents/in/Medecine_Interne"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3341854,"name":"Glipizide","url":"https://www.academia.edu/Documents/in/Glipizide"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378962-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="124378961"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/124378961/_100_years_at_the_Brugmann_Hospital_"><img alt="Research paper thumbnail of [100 years at the Brugmann Hospital]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">[100 years at the Brugmann Hospital]</div><div class="wp-workCard_item"><span>Revue médicale de Bruxelles</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378961"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378961"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378961; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378961-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="124378958"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124378958/Triac_3_5_3_Triiodo_Thyroacetic_Acid_Induced_Pseudohypothyroidism_"><img alt="Research paper thumbnail of Triac (3,5,3’Triiodo-Thyroacetic Acid) Induced « Pseudohypothyroidism »" class="work-thumbnail" src="https://attachments.academia-assets.com/118616092/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124378958/Triac_3_5_3_Triiodo_Thyroacetic_Acid_Induced_Pseudohypothyroidism_">Triac (3,5,3’Triiodo-Thyroacetic Acid) Induced « Pseudohypothyroidism »</a></div><div class="wp-workCard_item"><span>Acta Clinica Belgica</span><span>, 1984</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5cb542a8fbbdb1f0694e932cabb10a2c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118616092,"asset_id":124378958,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118616092/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124378958"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124378958"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124378958; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-124378958-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="122267223"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122267223/_Parenteral_administration_of_magnesium_in_spasmophilia_"><img alt="Research paper thumbnail of [Parenteral administration of magnesium in spasmophilia]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">[Parenteral administration of magnesium in spasmophilia]</div><div class="wp-workCard_item"><span>Revue médicale de Bruxelles</span><span>, 1986</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122267223"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122267223"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122267223; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462461-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462460"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462460/Hormonal_Changes_after_Jet_Lag_in_Normal_Man"><img alt="Research paper thumbnail of Hormonal Changes after Jet Lag in Normal Man" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Hormonal Changes after Jet Lag in Normal Man</div><div class="wp-workCard_item"><span>Advances in biological psychiatry</span><span>, Apr 16, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">info:eu-repo/semantics/publishe</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462460"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462460"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462460; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462460-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462459"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462459/Control_of_circadian_and_episodic_variations_of_adrenal_androgens_secretion_in_man"><img alt="Research paper thumbnail of Control of circadian and episodic variations of adrenal androgens' secretion in man" class="work-thumbnail" src="https://attachments.academia-assets.com/113313250/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462459/Control_of_circadian_and_episodic_variations_of_adrenal_androgens_secretion_in_man">Control of circadian and episodic variations of adrenal androgens' secretion in man</a></div><div class="wp-workCard_item"><span>Acta Clinica Belgica</span><span>, 1985</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r > 0.75; p< 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r>0.30; p<0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r > 0.30; P < 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f598e38b1cd11713fb431cac40552be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313250,"asset_id":117462459,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313250/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462459"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462459"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462459; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462459]").text(description); $(".js-view-count[data-work-id=117462459]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462459; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462459']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f598e38b1cd11713fb431cac40552be" } } $('.js-work-strip[data-work-id=117462459]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462459,"title":"Control of circadian and episodic variations of adrenal androgens' secretion in man","translated_title":"","metadata":{"publisher":"Maney Publishing","grobid_abstract":"The 24-h profiles of plasma cortisol (F), 11-J3-hydroxyandrostenedione (11 OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). 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The data were submitted to a detailed quantitative analysis including the estimation ofthe circadian rhythm and ofthe episodic variations as well as the evaluation of the concomitance of episodic pulses of different hormones. A bimodal circadian rhythm was detected in the various individual profiles. The major acrophase occurred in the morning earlier for T (around 04:00 h) than for the hormones oftotally or partially adrenal origin (around 07:00 h); the secondary acrophase (around 17:00 h) and the main midnight nadir were common to all hormones. The amplitude of the rhythm was highest for purely adrenal hormones (F and 11 OHAD), averaging 79 and 75%, respectively, lower for hormones of mixed origin (DHEA and AD), averaging 44 and 42%, respectively, and minimal for T (22%). The possible relationship between the circadian and pulsatile variations of the various steroids was estimated in each individual by calculating Pearson's standard coefficient of variation on all pairs of hormonal profiles. A very tight relationship (r \u003e 0.75; p\u003c 0.001) was found between the 4 adrenal hormones in each individual; a looser but significant correlation (r\u003e0.30; p\u003c0.001) was also detected between T and its partial precursors (AD and DHEA) and between T and the purely adrenal hormones: F and 11 OHAD (r \u003e 0.30; P \u003c 0.01). The pulsatility of the corticotrophic axis was readily transmitted to the secretory pattern of 11 OHAD, DHEA and AD. Ninety-six percent of the F pulses were reflected in at least one other hormonal profile. Finally, we showed that concomitant pulses common to the five adrenal and gonadal patterns were more frequent than would be expected on the basis of chance. These results: (1) demonstrate a total parallelism between the long-lasting secretory events and the episodic bursts of the 4 adrenal hormones showing that the reticular and fascicular zones of the adrenal respond to pituitary control as an homogeneous structure; (2) demonstrate the existence of a partial synchronization of adrenal and testicular pulsatile variations; (3) suggest that, throughout the afternoon, a common mechanism may influence the slow variations of adrenal hormones and of testicular testosterone.","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[{"id":113313250,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113313250/thumbnails/1.jpg","file_name":"BF0334812920240414-1-9bhu7p.pdf","download_url":"https://www.academia.edu/attachments/113313250/download_file","bulk_download_file_name":"Control_of_circadian_and_episodic_variat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113313250/BF0334812920240414-1-9bhu7p-libre.pdf?1713077816=\u0026response-content-disposition=attachment%3B+filename%3DControl_of_circadian_and_episodic_variat.pdf\u0026Expires=1744334630\u0026Signature=BSfYq7iyIuWFkMHTE6wZzXE650OLoXpJgUbnuL6RkwQ8~0Qsa8LIxx7spLF2qjZlFizuJ50gTq9UstG5tno1TRmbSDEmzDwaBeji~hMmdUMoeDONe7C33~BgShdY3Y2-mlU-ZlEjEcenJ7USyY1SACL2uYJKIcIQB10UPBTN1Dw05wycGDUBzk3OClKYX0mLaNV~nZSYZd4asaAnT8WerQW2Ri3Tj1UWnLrWF6CO87ItPpqDcUPw5358lEC~3EQQD7cJVOlol132eZLLZ2wOmF6daS-9pGu~sWaW2eJ1~ZXHpegTddV5VLoifqs9914OahA-vK41AhZ56EDu2lgjpw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":69056,"name":"Testosterone","url":"https://www.academia.edu/Documents/in/Testosterone"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":115898,"name":"Androgens","url":"https://www.academia.edu/Documents/in/Androgens"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"},{"id":564491,"name":"Dehydroepiandrosterone","url":"https://www.academia.edu/Documents/in/Dehydroepiandrosterone"},{"id":738276,"name":"Morning","url":"https://www.academia.edu/Documents/in/Morning"},{"id":1490737,"name":"Secretion","url":"https://www.academia.edu/Documents/in/Secretion"},{"id":2352882,"name":"Androstenedione","url":"https://www.academia.edu/Documents/in/Androstenedione"},{"id":2570781,"name":"Adrenal glands","url":"https://www.academia.edu/Documents/in/Adrenal_glands"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3359206,"name":"hydrocortisone","url":"https://www.academia.edu/Documents/in/hydrocortisone"}],"urls":[{"id":41076722,"url":"https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/228652/Details"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462459-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462458"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/117462458/Le_Service_dEndocrinologie"><img alt="Research paper thumbnail of Le Service d'Endocrinologie" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Le Service d'Endocrinologie</div><div class="wp-workCard_item"><span>Revue Médicale de Bruxelles</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">L&#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidien...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">L&#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidiennes, maladies hypothalamo-hypophysaires, surrenaliennes, gonadiques et parathyroidiennes, obesites, hypercholesterolemies et syndromes endocriniens paraneoplasiques. Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d&#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l&#39;axe thyreotrope chez l&#39;homme normal. Des etudes du jet lag ont permis d&#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. D&#39;autres travaux ont aborde la regulation du metabolisme des corps cetoniques, les rapports entre l&#39;etat nutritionnel et le metabolisme du glucose et divers aspects d&#39;immunodiabetologie.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462458"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462458"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462458; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462458]").text(description); $(".js-view-count[data-work-id=117462458]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462458; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462458']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462458]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462458,"title":"Le Service d'Endocrinologie","translated_title":"","metadata":{"abstract":"L\u0026#39;endocrinologie couvre la prise en charge et le traitement des diabetes, maladies thyroidiennes, maladies hypothalamo-hypophysaires, surrenaliennes, gonadiques et parathyroidiennes, obesites, hypercholesterolemies et syndromes endocriniens paraneoplasiques. Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d\u0026#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l\u0026#39;axe thyreotrope chez l\u0026#39;homme normal. Des etudes du jet lag ont permis d\u0026#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. 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Ces activites cliniques sont brievement decrites. Les activites de recherche du Service ont investigue la regulation du metabolisme thyroidien in vitro, le systeme generateur d\u0026#39;H 2 O 2 intrathyroidien, la physiopathologie des nodules thyroidiens toxiques et le vieillissement de l\u0026#39;axe thyreotrope chez l\u0026#39;homme normal. Des etudes du jet lag ont permis d\u0026#39;eclairer des aspects fondamentaux de la chronophysiologie hormonale. 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The investigation comprised a basal study in Brussels, a westward 7-hour time shift to Chicago, three studies in Chicago, an eastward flight back to Brussels, and three studies in Brussels. During each study, blood was drawn at 15 min intervals for 25 hours. Plasma adrenocorticotrophic hormone (ACTH) and Cortisol were measured in each sample. No quantitative alterations of the adrenocortical secretion were caused by jet lag. In all subjects the temporal organization of ACTH and Cortisol secretion was disrupted by the time shifts for at least 11 days after the flights. A dissociation in the rapidity of the adaptation of the time of maximal secretion and of the quiescent period was observed. 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Pathogeneti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SummarySeven patients presenting an empty sella turcica are presented in this report. Pathogenetical, semeiological, diagnostic and therapeuticaJ features of this syndrome are reviewed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462454"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462454"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462454; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462454]").text(description); $(".js-view-count[data-work-id=117462454]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462454; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462454']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462454]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462454,"title":"La Selle Turcique Vide: Une Symptomatologie Proteiforme","translated_title":"","metadata":{"abstract":"SummarySeven patients presenting an empty sella turcica are presented in this report. 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profile--work_container" data-work-id="117462453"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462453/Quantitative_analysis_of_spontaneous_variations_of_plasma_prolactin_in_normal_man"><img alt="Research paper thumbnail of Quantitative analysis of spontaneous variations of plasma prolactin in normal man" class="work-thumbnail" src="https://attachments.academia-assets.com/113313224/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462453/Quantitative_analysis_of_spontaneous_variations_of_plasma_prolactin_in_normal_man">Quantitative analysis of spontaneous variations of plasma prolactin in normal man</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-endocrinology and Metabolism</span><span>, Nov 1, 1981</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="466c71302533ed10c4632b98772b0019" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313224,"asset_id":117462453,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313224/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462453"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item 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src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">The Relationship between Episodic Variations of Plasma Prolactin and REM-Non-REM Cyclicity Is an Artifact*</div><div class="wp-workCard_item"><span>The Journal of Clinical Endocrinology and Metabolism</span><span>, 1982</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462452"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462452"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462452; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462452]").text(description); $(".js-view-count[data-work-id=117462452]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462452; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462452']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462452]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462452,"title":"The Relationship between Episodic Variations of Plasma Prolactin and REM-Non-REM Cyclicity Is an Artifact*","translated_title":"","metadata":{"abstract":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.","publisher":"Endocrine Society","publication_date":{"day":null,"month":null,"year":1982,"errors":{}},"publication_name":"The Journal of Clinical Endocrinology and Metabolism"},"translated_abstract":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.","internal_url":"https://www.academia.edu/117462452/The_Relationship_between_Episodic_Variations_of_Plasma_Prolactin_and_REM_Non_REM_Cyclicity_Is_an_Artifact_","translated_internal_url":"","created_at":"2024-04-13T23:45:18.719-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Relationship_between_Episodic_Variations_of_Plasma_Prolactin_and_REM_Non_REM_Cyclicity_Is_an_Artifact_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. 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IV. Time Shifts Increase Growth Hormone Release*" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Effects of “Jet Lag” on Hormonal Patterns. IV. Time Shifts Increase Growth Hormone Release*</div><div class="wp-workCard_item"><span>The Journal of Clinical Endocrinology and Metabolism</span><span>, Mar 1, 1983</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by &amp;quot;jet lag&amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462451"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462451"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462451; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117462451]").text(description); $(".js-view-count[data-work-id=117462451]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117462451; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117462451']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117462451]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117462451,"title":"Effects of “Jet Lag” on Hormonal Patterns. 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First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","publisher":"Endocrine Society","publication_date":{"day":1,"month":3,"year":1983,"errors":{}},"publication_name":"The Journal of Clinical Endocrinology and Metabolism"},"translated_abstract":"Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by \u0026amp;quot;jet lag\u0026amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","internal_url":"https://www.academia.edu/117462451/Effects_of_Jet_Lag_on_Hormonal_Patterns_IV_Time_Shifts_Increase_Growth_Hormone_Release_","translated_internal_url":"","created_at":"2024-04-13T23:45:18.456-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":70952271,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_Jet_Lag_on_Hormonal_Patterns_IV_Time_Shifts_Increase_Growth_Hormone_Release_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Twenty-four-hour GH profiles were obtained in five normal male volunteers before travel, 1, 11, and 21 days after the Brussels-Chicago flight (time shift, 7 h); and 1, 11, and 21 days after the return flight. The westward and eastward travels involved, respectively, periods of 23 and 33 h of sleep deprivation. One year later, two of the five volunteers were submitted, in the laboratory, to an investigation mimicking the conditions of sleep deprivation undergone in the course of the eastward travel and involving two 24-h periods of blood sampling. Blood samples were drawn every 15 min, and sleep was polygraphically monitored. The amounts of GH secreted were quantified, and their relationship with the different sleep stages was analyzed. Time shifts, whether caused by \u0026amp;quot;jet lag\u0026amp;quot; or by sleep deprivation in the laboratory, had two effects on GH secretory patterns. First, a marked increase in GH release, due to an augmentation of the magnitude, rather than the number, of secretory spikes was observed, independently of sleep disturbances. Return to basal levels was slower after westward than after eastward travel and took at least 11 days. Second, 1 day after the eastward transportation as well as immediately after 33 h of sleep deprivation, the major GH spike, which occurred in early sleep in the other studies, was shifted to late sleep. In these investigations, the only consistent alteration of sleep was a reduction in the amount of rapid eye movement (REM) stage. The occurrence of GH spikes in sleep was significantly associated with slow wave (SW) stage. However, total amounts of GH secreted during sleep were negatively correlated with the total duration of REM stages rather than positively correlated with the total duration of SW stages. A spike by spike analysis showed that the amount of GH secreted correlates best with the ratio (SW - REM) to (SW + REM), which relates the amount of REM preceding the spike to the amount of SW during the spike and thus constitutes an indicator of the status of the REM-non-REM oscillation.","impression_tracking_id":null,"owner":{"id":70952271,"first_name":"Daniel","middle_initials":null,"last_name":"Desir","page_name":"DanielDesir","domain_name":"ulb","created_at":"2017-11-06T03:15:51.866-08:00","display_name":"Daniel Desir","url":"https://ulb.academia.edu/DanielDesir"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52562,"name":"Growth Hormone","url":"https://www.academia.edu/Documents/in/Growth_Hormone"},{"id":57928,"name":"Travel","url":"https://www.academia.edu/Documents/in/Travel"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":76423,"name":"Sleep Deprivation","url":"https://www.academia.edu/Documents/in/Sleep_Deprivation"},{"id":89121,"name":"Circadian Rhythm","url":"https://www.academia.edu/Documents/in/Circadian_Rhythm"},{"id":99708,"name":"Clinical","url":"https://www.academia.edu/Documents/in/Clinical"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":445233,"name":"Hormone","url":"https://www.academia.edu/Documents/in/Hormone"},{"id":1772810,"name":"Sleep Stages","url":"https://www.academia.edu/Documents/in/Sleep_Stages"},{"id":2886523,"name":"endocrinologie","url":"https://www.academia.edu/Documents/in/endocrinologie"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":41076714,"url":"https://doi.org/10.1210/jcem-56-3-433"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-117462451-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="117462450"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117462450/Quantitative_characterization_of_ACTH_and_adrenocortical_episodic_secretion_in_man_An_introduction"><img alt="Research paper thumbnail of Quantitative characterization of ACTH and adrenocortical episodic secretion in man: An introduction" class="work-thumbnail" src="https://attachments.academia-assets.com/113313248/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117462450/Quantitative_characterization_of_ACTH_and_adrenocortical_episodic_secretion_in_man_An_introduction">Quantitative characterization of ACTH and adrenocortical episodic secretion in man: An introduction</a></div><div class="wp-workCard_item"><span>Journal of Steroid Biochemistry</span><span>, Jul 1, 1983</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6c333ea9e110aa6c2f43c2003fb0cff6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113313248,"asset_id":117462450,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113313248/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117462450"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117462450"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117462450; 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