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Many studies and researches are continuously done to achieve a paramount strategy in" /> <meta name="twitter:image" content="https://0.academia-photos.com/45516161/31594399/28932252/s200_michelle.valeria.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review" /> <meta property="og:title" content="Tissue Engineering and Regenerative Medicine: A Review" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in" /> <meta property="article:author" content="https://independent.academia.edu/MichelleValeria3" /> <meta name="description" content="Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in" /> <title>(PDF) Tissue Engineering and Regenerative Medicine: A Review | Michelle Valeria - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732439794000); window.Aedu.timeDifference = new Date().getTime() - 1732439794000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering. Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh...","author":[{"@context":"https://schema.org","@type":"Person","name":"Michelle Valeria"}],"contributor":[],"dateCreated":"2022-02-08","dateModified":"2022-02-09","datePublished":null,"headline":"Tissue Engineering and Regenerative Medicine: A Review","inLanguage":"en","keywords":[],"locationCreated":null,"publication":"Jurnal Plastik Rekonstruksi","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Jurnal Plastik Rekonstruksi"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" 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Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering. Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh...","publisher":"Jurnal Plastik Rekonstruksi","publication_name":"Jurnal Plastik Rekonstruksi"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Tissue Engineering and Regenerative Medicine: A Review","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [45516161]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":80502774,"attachmentType":"pdf"}"><img alt="First page of “Tissue Engineering and Regenerative Medicine: A Review”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/80502774/mini_magick20220208-16557-30ewbt.png?1644375352" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Tissue Engineering and Regenerative Medicine: A Review</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="45516161" href="https://independent.academia.edu/MichelleValeria3"><img alt="Profile image of Michelle Valeria" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/45516161/31594399/28932252/s65_michelle.valeria.jpg" />Michelle Valeria</a></div><p class="ds-work-card--detail ds2-5-body-sm">Jurnal Plastik Rekonstruksi</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering. Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":80502774,"attachmentType":"pdf","workUrl":"https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":80502774,"attachmentType":"pdf","workUrl":"https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="80502774" data-landing_url="https://www.academia.edu/70970627/Tissue_Engineering_and_Regenerative_Medicine_A_Review" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="97138061" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/97138061/Tissue_Engineering_From_Basic_Sciences_to_Clinical_Perspectives">Tissue Engineering: From Basic Sciences to Clinical Perspectives</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15180952" href="https://independent.academia.edu/PornanongAramwit">Pornanong Aramwit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BioMed research international, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering: From Basic Sciences to Clinical Perspectives","attachmentId":98843027,"attachmentType":"pdf","work_url":"https://www.academia.edu/97138061/Tissue_Engineering_From_Basic_Sciences_to_Clinical_Perspectives","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/97138061/Tissue_Engineering_From_Basic_Sciences_to_Clinical_Perspectives"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="56229916" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56229916/Tissue_Engineering_Challenges_and_Selected_Application">Tissue Engineering: Challenges and Selected Application</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="158270351" href="https://independent.academia.edu/MaksymPogorielov">Maksym Pogorielov</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Advances in Tissue Engineering & Regenerative Medicine: Open Access</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering: Challenges and Selected Application","attachmentId":71718259,"attachmentType":"pdf","work_url":"https://www.academia.edu/56229916/Tissue_Engineering_Challenges_and_Selected_Application","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56229916/Tissue_Engineering_Challenges_and_Selected_Application"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="75471193" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/75471193/Challenges_in_tissue_engineering">Challenges in tissue engineering</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34812330" href="https://independent.academia.edu/YoshitoIkada">Yoshito Ikada</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of The Royal Society Interface - J R SOC INTERFACE, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Challenges in tissue engineering","attachmentId":83475753,"attachmentType":"pdf","work_url":"https://www.academia.edu/75471193/Challenges_in_tissue_engineering","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/75471193/Challenges_in_tissue_engineering"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="109813031" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109813031/Tissue_Engineering_Concepts">Tissue Engineering Concepts</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20170309" href="https://ufabc-br.academia.edu/ArnaldoSantosJr">Arnaldo Santos Jr</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Reference Module in Materials Science and Materials Engineering, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">One of the most significant breakthroughs in the field of mammalian regeneration has been the application of principles of bioengineering to guiding tissue regeneration. This approach is called tissue engineering. The goal of tissue engineering is the replacement of damaged tissues and organs with new tissue that mimics as closely as possible the overall structure and function of the original tissue. Some general strategies have been adopted to obtain new tissues they are: (1) use of autologous cells sources; (2) production of a scaffold for damaged target tissue; (3) tissue culture systems, and (4) Use of substances that induce the regeneration of damaged tissue. In this work, we discuss main aspects in the tissue engineering field.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering Concepts","attachmentId":112470575,"attachmentType":"pdf","work_url":"https://www.academia.edu/109813031/Tissue_Engineering_Concepts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/109813031/Tissue_Engineering_Concepts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="101589669" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/101589669/Tissue_Engineering_Current_Status_and_Futuristic_Scope">Tissue Engineering; Current Status & Futuristic Scope</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="172202773" href="https://independent.academia.edu/PDhot">Paramjit Dhot</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Medicine and Life, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Almost 30 years have passed since the term ‘tissue engineering’ was created to represent a new concept that focuses on the regeneration of neotissues from cells with the support of biomaterials and growth factors. This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have also been aiming at replacing lost or severely damaged tissues or organs. However, the tissues regenerated by tissue engineering and widely applied to patients are still minimal, including skin, bone, cartilage, capillary, and periodontal tissues. What are the reasons for such slow advances in clinical applications of tissue engineering? This article gives a brief overview of the current state of tissue engineering, covering the fundamentals and applications. The fundamentals of tissue engineering involve cell sources, scaffolds for cell expansion and differentiation, as well...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering; Current Status \u0026 Futuristic Scope","attachmentId":102089282,"attachmentType":"pdf","work_url":"https://www.academia.edu/101589669/Tissue_Engineering_Current_Status_and_Futuristic_Scope","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/101589669/Tissue_Engineering_Current_Status_and_Futuristic_Scope"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="40188753" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration">Tissue Engineering: A Boon to Tissue Regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27442451" href="https://university.academia.edu/SowjanyaPulipati">PULIPATI SOWJANYA</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Inventi Rapid: Pharm Biotech & Microbio, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">The artificial generation of tissues, organs or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. Tissue engineering and regenerative medicine are terms in biomedical field that deal with the transformations. Tissue Engineering (TE) is a scientific field mainly focused on the development of tissue and organ substitutes by controlling biological, biophysical and/or biomechanical parameters in the laboratory. This results in elaboration of threedimensional cellular constructs with properties more similar to natural tissues than classical monolayer cultures. These systems enable the in-vitro study of human physiology and physiopathology more accurately, while providing a set of biomedical tools with potential applicability in toxicology, medical devices, tissue replacement, repair and regeneration. To succeed in these purposes, TE uses nature as an inspiration source for the generation of extracellular matrix analogues (scaffolds), either from natural or synthetic origin as well as bioreactors and bio-devices to mimic natural physiological conditions of particular tissues. These scaffolds embed cells in a three dimensional milieu that display signals critical for the determination of cellular fate, in terms of proliferation, differentiation and migration, among others. The aim of this review is to analyze the state of the art of TE and some of its application fields.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering: A Boon to Tissue Regeneration","attachmentId":60412312,"attachmentType":"pdf","work_url":"https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/40188753/Tissue_Engineering_A_Boon_to_Tissue_Regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="120860258" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/120860258/Cell_Engineering_and_Regeneration">Cell Engineering and Regeneration</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33084706" href="https://independent.academia.edu/SusanneWolbank">Susanne Wolbank</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Reference Series in Biomedical Engineering, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cell Engineering and Regeneration","attachmentId":115878728,"attachmentType":"pdf","work_url":"https://www.academia.edu/120860258/Cell_Engineering_and_Regeneration","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/120860258/Cell_Engineering_and_Regeneration"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="68583690" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/68583690/Advances_in_Regenerative_Medicine_and_Tissue_Engineering_Innovation_and_Transformation_of_Medicine">Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38366464" href="https://uct.academia.edu/KevinDzobo">Kevin Dzobo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Stem cells international, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Humans and animals lose tissues and organs due to congenital defects, trauma, and diseases. The human body has a low regenerative potential as opposed to the urodele amphibians commonly referred to as salamanders. Globally, millions of people would benefit immensely if tissues and organs can be replaced on demand. Traditionally, transplantation of intact tissues and organs has been the bedrock to replace damaged and diseased parts of the body. The sole reliance on transplantation has created a waiting list of people requiring donated tissues and organs, and generally, supply cannot meet the demand. The total cost to society in terms of caring for patients with failing organs and debilitating diseases is enormous. Scientists and clinicians, motivated by the need to develop safe and reliable sources of tissues and organs, have been improving therapies and technologies that can regenerate tissues and in some cases create new tissues altogether. Tissue engineering and/or regenerative me...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine","attachmentId":79011211,"attachmentType":"pdf","work_url":"https://www.academia.edu/68583690/Advances_in_Regenerative_Medicine_and_Tissue_Engineering_Innovation_and_Transformation_of_Medicine","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/68583690/Advances_in_Regenerative_Medicine_and_Tissue_Engineering_Innovation_and_Transformation_of_Medicine"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="30783093" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30783093/Tissue_Engineering_Key_Elements_and_Some_Trends">Tissue Engineering: Key Elements and Some Trends</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32936040" href="https://uminho.academia.edu/RuiReis">Rui L Reis</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Macromolecular Bioscience, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering: Key Elements and Some Trends","attachmentId":51217712,"attachmentType":"pdf","work_url":"https://www.academia.edu/30783093/Tissue_Engineering_Key_Elements_and_Some_Trends","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30783093/Tissue_Engineering_Key_Elements_and_Some_Trends"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="103219862" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103219862/Tissue_engineering_and_surgery_from_translational_studies_to_human_trials">Tissue engineering and surgery: from translational studies to human trials</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58181796" href="https://independent.academia.edu/JanVranckx">Jan Vranckx</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Innovative Surgical Sciences, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Tissue engineering was introduced as an innovative and promising field in the mid-1980s. The capacity of cells to migrate and proliferate in growth-inducing medium induced great expectancies on generating custom-shaped bioconstructs for tissue regeneration. Tissue engineering represents a unique multidisciplinary translational forum where the principles of biomaterial engineering, the molecular biology of cells and genes, and the clinical sciences of reconstruction would interact intensively through the combined efforts of scientists, engineers, and clinicians. The anticipated possibilities of cell engineering, matrix development, and growth factor therapies are extensive and would largely expand our clinical reconstructive armamentarium. Application of proangiogenic proteins may stimulate wound repair, restore avascular wound beds, or reverse hypoxia in flaps. Autologous cells procured from biopsies may generate an ‘autologous’ dermal and epidermal laminated cover on extensive burn...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue engineering and surgery: from translational studies to human trials","attachmentId":103284171,"attachmentType":"pdf","work_url":"https://www.academia.edu/103219862/Tissue_engineering_and_surgery_from_translational_studies_to_human_trials","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103219862/Tissue_engineering_and_surgery_from_translational_studies_to_human_trials"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":80502774,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":80502774,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_80502774" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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