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Giannone</title> <meta name="description" content="Search results for: Virgilio Giannone"> <meta name="keywords" content="Virgilio Giannone"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Virgilio Giannone"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 6</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Virgilio Giannone</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Production of Functional Crackers Enriched with Olive (Olea europaea L.) Leaf Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rosa%20Palmeri">Rosa Palmeri</a>, <a href="https://publications.waset.org/abstracts/search?q=Julieta%20I.%20Monteleone"> Julieta I. Monteleone</a>, <a href="https://publications.waset.org/abstracts/search?q=Antonio%20C.%20Barbera"> Antonio C. Barbera</a>, <a href="https://publications.waset.org/abstracts/search?q=Carmelo%20Maucieri"> Carmelo Maucieri</a>, <a href="https://publications.waset.org/abstracts/search?q=Aldo%20Todaro"> Aldo Todaro</a>, <a href="https://publications.waset.org/abstracts/search?q=Virgilio%20Giannone"> Virgilio Giannone</a>, <a href="https://publications.waset.org/abstracts/search?q=Giovanni%20Spagna"> Giovanni Spagna</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, considerable interest has been shown in the functional properties of foods, and a relevant role has been played by phenolic compounds, able to scavenge free radicals. A more sustainable agriculture has to emerge to guarantee food supply over the next years. Wheat, corn, and rice are the most common cereals cultivated, but also other cereal species, such as barley can be appreciated for their peculiarities. Barley (Hordeum vulgare L.) is a C3 winter cereal that shows high resistance at drought and salt stresses. There are growing interests in barley as ingredient for the production of functional foods due to its high content of phenolic compounds and Beta-glucans. In this respect, the possibility of separating specific functional fractions from food industry by-products looks very promising. Olive leaves represent a quantitatively significant by-product of olive grove farming, and are an interesting source of phenolic compounds. In particular, oleuropein, which provide important nutritional benefits, is the main phenolic compound in olive leaves and ranges from 17% to 23% depending upon the cultivar and growing season period. Together with oleuropein and its derivatives (e.g. dimethyloleuropein, oleuropein diglucoside), olive leaves further contain tyrosol, hydroxytyrosol, and a series of secondary metabolities structurally related to them: verbascoside, ligstroside, hydroxytyrosol glucoside, tyrosol glucoside, oleuroside, oleoside-11-methyl ester, and nuzhenide. Several flavonoids, flavonoid glycosides, and phenolic acids have also described in olive leaves. The aim of this work was the production of functional food with higher content of polyphenols and the evaluation of their shelf life. Organic durum wheat and barley grains contain higher levels of phenolic compounds were used for the production of crackers. Olive leaf extract (OLE) was obtained from cv. ‘Biancolilla’ by aqueous extraction method. Two baked goods trials were performed with both organic durum wheat and barley flours, adding olive leaf extract. Control crackers, made as comparison, were produced with the same formulation replacing OLE with water. Total phenolic compound, moisture content, activity water, and textural properties at different time of storage were determined to evaluate the shelf-life of the products. Our the preliminary results showed that the enriched crackers showed higher phenolic content and antioxidant activity than control. Alternative uses of olive leaf extracts for crackers production could represent a good candidate for the addition of functional ingredients because bakery items are daily consumed, and have long shelf-life. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=barley" title="barley">barley</a>, <a href="https://publications.waset.org/abstracts/search?q=functional%20foods" title=" functional foods"> functional foods</a>, <a href="https://publications.waset.org/abstracts/search?q=olive%20leaf" title=" olive leaf"> olive leaf</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenols" title=" polyphenols"> polyphenols</a>, <a href="https://publications.waset.org/abstracts/search?q=shelf%20life" title=" shelf life"> shelf life</a> </p> <a href="https://publications.waset.org/abstracts/53423/production-of-functional-crackers-enriched-with-olive-olea-europaea-l-leaf-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53423.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">302</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> A Comparison of Outcomes of Endoscopic Retrograde Cholangiopancreatography vs. Percutaneous Transhepatic Biliary Drainage in the Management of Obstructive Jaundice from Hepatobiliary Tuberculosis: The Philippine General Hospital Experience</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Margaret%20Elaine%20J.%20Villamayor">Margaret Elaine J. Villamayor</a>, <a href="https://publications.waset.org/abstracts/search?q=Lobert%20A.%20Padua"> Lobert A. Padua</a>, <a href="https://publications.waset.org/abstracts/search?q=Neil%20S.%20Bacaltos"> Neil S. Bacaltos</a>, <a href="https://publications.waset.org/abstracts/search?q=Virgilio%20P.%20Ba%C3%B1ez"> Virgilio P. Bañez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Significance: This study aimed to determine the prevalence of Hepatobiliary Tuberculosis (HBTB) with biliary obstruction and to compare the outcomes of ERCP versus PTBD in these patients. Methodology: This is a cross-sectional study involving patients from PGH who underwent biliary drainage from HBTB from January 2009 to June 2014. HBTB was defined as having evidence of TB (culture, smear, PCR, histology) or clinical diagnosis with the triad of jaundice, fever, and calcifications on imaging with other causes of jaundice excluded. The primary outcome was successful drainage and secondary outcomes were mean hospital stay and complications. Simple logistic regression was used to identify factors associated with success of drainage, z-test for two proportions to compare outcomes of ERCP versus PTBD and t-test to compare mean hospital stay post-procedure. Results: There were 441 patients who underwent ERCP and PTBD, 19 fulfilled the inclusion criteria. 11 underwent ERCP while 8 had PTBD. There were more successful cases in PTBD versus ERCP but this was not statistically significant (p-value 0.3615). Factors such as age, gender, location and nature of obstruction, vices, coexisting pulmonary or other extrapulmonary TB and presence of portal hypertension did not affect success rates in these patients. The PTBD group had longer mean hospital stay but this was not significant (p-value 0.1880). There were no complications reported in both groups. Conclusion: HBTB comprises 4.3% of the patients undergoing biliary drainage in PGH. Both ERCP and PTBD are equally safe and effective in the management of biliary obstruction from HBTB. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cross-sectional" title="cross-sectional">cross-sectional</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatobiliary%20tuberculosis" title=" hepatobiliary tuberculosis"> hepatobiliary tuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=obstructive%20jaundice" title=" obstructive jaundice"> obstructive jaundice</a>, <a href="https://publications.waset.org/abstracts/search?q=endoscopic%20retrograde%20cholangiopancreatography" title=" endoscopic retrograde cholangiopancreatography"> endoscopic retrograde cholangiopancreatography</a>, <a href="https://publications.waset.org/abstracts/search?q=percutaneous%20transhepatic%20biliary%20drainage" title=" percutaneous transhepatic biliary drainage "> percutaneous transhepatic biliary drainage </a> </p> <a href="https://publications.waset.org/abstracts/26346/a-comparison-of-outcomes-of-endoscopic-retrograde-cholangiopancreatography-vs-percutaneous-transhepatic-biliary-drainage-in-the-management-of-obstructive-jaundice-from-hepatobiliary-tuberculosis-the-philippine-general-hospital-experience" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">445</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Optical and Structural Characterization of Rare Earth Doped Phosphate Glasses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Z%C3%A9lia%20Maria%20Da%20Costa%20Ludwig">Zélia Maria Da Costa Ludwig</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Jos%C3%A9%20Valenzuela%20Bell"> Maria José Valenzuela Bell</a>, <a href="https://publications.waset.org/abstracts/search?q=Geraldo%20Henriques%20Da%20Silva"> Geraldo Henriques Da Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Thales%20Alves%20Faraco"> Thales Alves Faraco</a>, <a href="https://publications.waset.org/abstracts/search?q=Victor%20Rocha%20Da%20Silva"> Victor Rocha Da Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Daniel%20Rotmeister%20Teixeira"> Daniel Rotmeister Teixeira</a>, <a href="https://publications.waset.org/abstracts/search?q=V%C3%ADrgilio%20De%20Carvalho%20Dos%20Anjos"> Vírgilio De Carvalho Dos Anjos</a>, <a href="https://publications.waset.org/abstracts/search?q=Valdemir%20Ludwig"> Valdemir Ludwig</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Advances in telecommunications grow with the development of optical amplifiers based on rare earth ions. The focus has been concentrated in silicate glasses although their amplified spontaneous emission is limited to a few tens of nanometers (~ 40nm). Recently, phosphate glasses have received great attention due to their potential application in optical data transmission, detection, sensors and laser detector, waveguide and optical fibers, besides its excellent physical properties such as high thermal expansion coefficients and low melting temperature. Compared with the silica glasses, phosphate glasses provide different optical properties such as, large transmission window of infrared, and good density. Research on the improvement of physical and chemical durability of phosphate glass by addition of heavy metals oxides in P2O5 has been performed. The addition of Na2O further improves the solubility of rare earths, while increasing the Al2O3 links in the P2O5 tetrahedral results in increased durability and aqueous transition temperature and a decrease of the coefficient of thermal expansion. This work describes the structural and spectroscopic characterization of a phosphate glass matrix doped with different Er (Erbium) concentrations. The phosphate glasses containing Er3+ ions have been prepared by melt technique. A study of the optical absorption, luminescence and lifetime was conducted in order to characterize the infrared emission of Er3+ ions at 1540 nm, due to the radiative transition 4I13/2 → 4I15/2. Our results indicate that the present glass is a quite good matrix for Er3+ ions, and the quantum efficiency of the 1540 nm emission was high. A quenching mechanism for the mentioned luminescence was not observed up to 2,0 mol% of Er concentration. The Judd-Ofelt parameters, radiative lifetime and quantum efficiency have been determined in order to evaluate the potential of Er3+ ions in new phosphate glass. The parameters follow the trend as Ω2 > Ω4 > Ω6. It is well known that the parameter Ω2 is an indication of the dominant covalent nature and/or structural changes in the vicinity of the ion (short range effects), while Ω4 and Ω6 intensity parameters are long range parameters that can be related to the bulk properties such as viscosity and rigidity of the glass. From the PL measurements, no red or green upconversion was measured when pumping the samples with laser excitation at 980 nm. As future prospects: Synthesize this glass system with silver in order to determine the influence of silver nanoparticles on the Er3+ ions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phosphate%20glass" title="phosphate glass">phosphate glass</a>, <a href="https://publications.waset.org/abstracts/search?q=erbium" title=" erbium"> erbium</a>, <a href="https://publications.waset.org/abstracts/search?q=luminescence" title=" luminescence"> luminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=glass%20system" title=" glass system"> glass system</a> </p> <a href="https://publications.waset.org/abstracts/27070/optical-and-structural-characterization-of-rare-earth-doped-phosphate-glasses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27070.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">510</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Wetting Characterization of High Aspect Ratio Nanostructures by Gigahertz Acoustic Reflectometry</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20Virgilio">C. Virgilio</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Carlier"> J. Carlier</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Campistron"> P. Campistron</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Toubal"> M. Toubal</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Garnier"> P. Garnier</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Broussous"> L. Broussous</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Thomy"> V. Thomy</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Nongaillard"> B. Nongaillard</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wetting efficiency of microstructures or nanostructures patterned on Si wafers is a real challenge in integrated circuits manufacturing. In fact, bad or non-uniform wetting during wet processes limits chemical reactions and can lead to non-complete etching or cleaning inside the patterns and device defectivity. This issue is more and more important with the transistors size shrinkage and concerns mainly high aspect ratio structures. Deep Trench Isolation (DTI) structures enabling pixels’ isolation in imaging devices are subject to this phenomenon. While low-frequency acoustic reflectometry principle is a well-known method for Non Destructive Test applications, we have recently shown that it is also well suited for nanostructures wetting characterization in a higher frequency range. In this paper, we present a high-frequency acoustic reflectometry characterization of DTI wetting through a confrontation of both experimental and modeling results. The acoustic method proposed is based on the evaluation of the reflection of a longitudinal acoustic wave generated by a 100 µm diameter ZnO piezoelectric transducer sputtered on the silicon wafer backside using MEMS technologies. The transducers have been fabricated to work at 5 GHz corresponding to a wavelength of 1.7 µm in silicon. The DTI studied structures, manufactured on the wafer frontside, are crossing trenches of 200 nm wide and 4 µm deep (aspect ratio of 20) etched into a Si wafer frontside. In that case, the acoustic signal reflection occurs at the bottom and at the top of the DTI enabling its characterization by monitoring the electrical reflection coefficient of the transducer. A Finite Difference Time Domain (FDTD) model has been developed to predict the behavior of the emitted wave. The model shows that the separation of the reflected echoes (top and bottom of the DTI) from different acoustic modes is possible at 5 Ghz. A good correspondence between experimental and theoretical signals is observed. The model enables the identification of the different acoustic modes. The evaluation of DTI wetting is then performed by focusing on the first reflected echo obtained through the reflection at Si bottom interface, where wetting efficiency is crucial. The reflection coefficient is measured with different water / ethanol mixtures (tunable surface tension) deposited on the wafer frontside. Two cases are studied: with and without PFTS hydrophobic treatment. In the untreated surface case, acoustic reflection coefficient values with water show that liquid imbibition is partial. In the treated surface case, the acoustic reflection is total with water (no liquid in DTI). The impalement of the liquid occurs for a specific surface tension but it is still partial for pure ethanol. DTI bottom shape and local pattern collapse of the trenches can explain these incomplete wetting phenomena. This high-frequency acoustic method sensitivity coupled with a FDTD propagative model thus enables the local determination of the wetting state of a liquid on real structures. Partial wetting states for non-hydrophobic surfaces or low surface tension liquids are then detectable with this method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=wetting" title="wetting">wetting</a>, <a href="https://publications.waset.org/abstracts/search?q=acoustic%20reflectometry" title=" acoustic reflectometry"> acoustic reflectometry</a>, <a href="https://publications.waset.org/abstracts/search?q=gigahertz" title=" gigahertz"> gigahertz</a>, <a href="https://publications.waset.org/abstracts/search?q=semiconductor" title=" semiconductor"> semiconductor</a> </p> <a href="https://publications.waset.org/abstracts/39734/wetting-characterization-of-high-aspect-ratio-nanostructures-by-gigahertz-acoustic-reflectometry" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39734.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">327</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Stakeholder Perception in the Role of Short-term Accommodations on the Place Brand and Real Estate Development of Urban Areas: A Case Study of Malate, Manila</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Virgilio%20Angelo%20Gelera%20Gener">Virgilio Angelo Gelera Gener</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study investigates the role of short-term accommodations on the place brand and real estate development of urban areas. It aims to know the perceptions of the general public, real estate developers, as well as city and barangay-level local government units (LGUs) on how these lodgings affect the place brand and land value of a community. It likewise attempts to identify the personal and institutional variables having a great influence on said perceptions in order to provide a better understanding of these establishments and their relevance within urban localities. Using certain sources, Malate, Manila was identified to be the ideal study area of the thesis. This prompted the employment of mixed methods research as the study’s fundamental data gathering and analytical tool. Here, a survey with 350 locals was done, asking them questions that would answer the aforementioned queries. Thereafter, a Pearson Chi-square Test and Multinomial Logistic Regression (MLR) were utilized to determine the variables affecting their perceptions. There were also Focus Group Discussions (FGDs) with the three (3) most populated Malate barangays, as well as Key Informant Interviews (KIIs) with selected city officials and fifteen (15) real estate company representatives. With that, survey results showed that although a 1992 Department of Tourism (DOT) Circular regards short-term accommodations as lodgings mainly for travelers, most people actually use it for their private/intimate moments. Because of this, the survey further revealed that short-term accommodations exhibit a negative place brand among the respondents though they also believe that it’s still one of society’s most important economic players. Statistics from the Pearson Chi-square Test, on the other hand, indicate that there are fourteen (14) out of seventeen (17) variables exhibiting great influence on respondents’ perceptions. Whereas MLR findings show that being born in Malate and being part of a family household was the most significant regardless of socio-economic level and monthly household income. For the city officials, it was revealed that said lodgings are actually the second-highest earners in the City’s lodging industry. It was further stated that their zoning ordinance treats short-term accommodations just like any other lodging enterprise. So it’s perfectly legal for these establishments to situate themselves near residential areas and/or institutional structures. A sit down with barangays, on the other hand, recognized the economic benefits of short-term accommodations but likewise admitted that it contributes a negative place brand to the community. Lastly, real estate developers are amenable to having their projects built near short-term accommodations, for they do not have any bad views against it. They explained that their projects sites have always been motivated by suitability, liability, and marketability factors only. Overall, these findings merit a recalibration of the zoning ordinance and DOT Circular, as well as the imposition of regulations on their sexually suggestive roadside advertisements. Then, once relevant measures are refined for proper implementation, it can also pave the way for spatial interventions (like visual buffer corridors) to better address the needs of the locals, private groups, and government. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=estate%20planning" title="estate planning">estate planning</a>, <a href="https://publications.waset.org/abstracts/search?q=place%20brand" title=" place brand"> place brand</a>, <a href="https://publications.waset.org/abstracts/search?q=real%20estate%20development" title=" real estate development"> real estate development</a>, <a href="https://publications.waset.org/abstracts/search?q=short-term%20accommodations" title=" short-term accommodations"> short-term accommodations</a> </p> <a href="https://publications.waset.org/abstracts/143234/stakeholder-perception-in-the-role-of-short-term-accommodations-on-the-place-brand-and-real-estate-development-of-urban-areas-a-case-study-of-malate-manila" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143234.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">165</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Impact of Simulated Brain Interstitial Fluid Flow on the Chemokine CXC-Chemokine-Ligand-12 Release From an Alginate-Based Hydrogel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Wiam%20El%20Kheir">Wiam El Kheir</a>, <a href="https://publications.waset.org/abstracts/search?q=Anais%20Dumais"> Anais Dumais</a>, <a href="https://publications.waset.org/abstracts/search?q=Maude%20Beaudoin"> Maude Beaudoin</a>, <a href="https://publications.waset.org/abstracts/search?q=Bernard%20Marcos"> Bernard Marcos</a>, <a href="https://publications.waset.org/abstracts/search?q=Nick%20Virgilio"> Nick Virgilio</a>, <a href="https://publications.waset.org/abstracts/search?q=Benoit%20Paquette"> Benoit Paquette</a>, <a href="https://publications.waset.org/abstracts/search?q=Nathalie%20Faucheux"> Nathalie Faucheux</a>, <a href="https://publications.waset.org/abstracts/search?q=Marc-Antoine%20Lauzon"> Marc-Antoine Lauzon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The high infiltrative pattern of glioblastoma multiforme cells (GBM) is the main cause responsible for the actual standard treatments failure. The tumor high heterogeneity, the interstitial fluid flow (IFF) and chemokines guides GBM cells migration in the brain parenchyma resulting in tumor recurrence. Drug delivery systems emerged as an alternative approach to develop effective treatments for the disease. Some recent studies have proposed to harness the effect CXC-lchemokine-ligand-12 to direct and control the cancer cell migration through delivery system. However, the dynamics of the brain environment on the delivery system remains poorly understood. Nanoparticles (NPs) and hydrogels are known as good carriers for the encapsulation of different agents and control their release. We studied the release of CXCL12 (free or loaded into NPs) from an alginate-based hydrogel under static and indirect perfusion (IP) conditions. Under static conditions, the main phenomena driving CXCL12 release from the hydrogel was diffusion with the presence of strong interactions between the positively charged CXCL12 and the negatively charge alginate. CXCL12 release profiles were independent from the initial mass loadings. Afterwards, we demonstrated that the release could tuned by loading CXCL12 into Alginate/Chitosan-Nanoparticles (Alg/Chit-NPs) and embedded them into alginate-hydrogel. The initial burst release was substantially attenuated and the overall cumulative release percentages of 21%, 16% and 7% were observed for initial mass loadings of 0.07, 0.13 and 0.26 µg, respectively, suggesting stronger electrostatic interactions. Results were mathematically modeled based on Fick’s second law of diffusion framework developed previously to estimate the effective diffusion coefficient (Deff) and the mass transfer coefficient. Embedding the CXCL12 into NPs decreased the Deff an order of magnitude, which was coherent with experimental data. Thereafter, we developed an in-vitro 3D model that takes into consideration the convective contribution of the brain IFF to study CXCL12 release in an in-vitro microenvironment that mimics as faithfully as possible the human brain. From is unique design, the model also allowed us to understand the effect of IP on CXCL12 release in respect to time and space. Four flow rates (0.5, 3, 6.5 and 10 µL/min) which may increase CXCL12 release in-vivo depending on the tumor location were assessed. Under IP, cumulative percentages varying between 4.5-7.3%, 23-58.5%, 77.8-92.5% and 89.2-95.9% were released for the three initial mass loadings of 0.08, 0.16 and 0.33 µg, respectively. As the flow rate increase, IP culture conditions resulted in a higher release of CXCL12 compared to static conditions as the convection contribution became the main driving mass transport phenomena. Further, depending on the flow rate, IP had a direct impact on CXCL12 distribution within the simulated brain tissue, which illustrates the importance of developing such 3D in-vitro models to assess the efficiency of a delivery system targeting the brain. In future work, using this very model, we aim to understand the impact of the different phenomenon occurring on GBM cell behaviors in response to the resulting chemokine gradient subjected to various flow while allowing them to express their invasive characteristics in an in-vitro microenvironment that mimics the in-vivo brain parenchyma. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20culture%20system" title="3D culture system">3D culture system</a>, <a href="https://publications.waset.org/abstracts/search?q=chemokines%20gradient" title=" chemokines gradient"> chemokines gradient</a>, <a href="https://publications.waset.org/abstracts/search?q=glioblastoma%20multiforme" title=" glioblastoma multiforme"> glioblastoma multiforme</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetic%20release" title=" kinetic release"> kinetic release</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20modeling" title=" mathematical modeling"> mathematical modeling</a> </p> <a href="https://publications.waset.org/abstracts/165359/impact-of-simulated-brain-interstitial-fluid-flow-on-the-chemokine-cxc-chemokine-ligand-12-release-from-an-alginate-based-hydrogel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165359.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a 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