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mw-list-item"><a href="https://et.wikipedia.org/wiki/Luu_morfogeneetiline_valk_5" title="Luu morfogeneetiline valk 5 – Estonian" lang="et" hreflang="et" data-title="Luu morfogeneetiline valk 5" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%BE%D8%B1%D9%88%D8%AA%D8%A6%DB%8C%D9%86_%DB%B5_%D8%B1%DB%8C%D8%AE%D8%AA%E2%80%8C%D8%B2%D8%A7%DB%8C%DB%8C_%D8%A7%D8%B3%D8%AA%D8%AE%D9%88%D8%A7%D9%86" title="پروتئین ۵ ریخت‌زایی استخوان – Persian" lang="fa" hreflang="fa" data-title="پروتئین ۵ ریخت‌زایی استخوان" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/BMP5" title="BMP5 – Ukrainian" lang="uk" hreflang="uk" data-title="BMP5" 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data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">BMP5</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/1072">BMP5</a></span>, entrez:653, bone morphogenetic protein 5</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/112265">112265</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:88181">88181</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=22412">22412</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP5">BMP5</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000112175">BMP5 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/450px-Ideogram_human_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/600px-Ideogram_human_chromosome_6.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chromosome 6 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_6_ideogram.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/300px-Human_chromosome_6_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/450px-Human_chromosome_6_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/600px-Human_chromosome_6_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 90.71451147494px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BMP5"><img alt="Genomic location for BMP5" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 96.7px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BMP5"><img alt="Genomic location for BMP5" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">6p12.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">55,753,653 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">55,875,590 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/260px-Ideogram_house_mouse_chromosome_9.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/390px-Ideogram_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/520px-Ideogram_house_mouse_chromosome_9.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 9 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/300px-Ideogram_of_house_mouse_chromosome_9.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/450px-Ideogram_of_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/600px-Ideogram_of_house_mouse_chromosome_9.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 173.41242880118px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for BMP5"><img alt="Genomic location for BMP5" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 179.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for BMP5"><img alt="Genomic location for BMP5" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">9 D|9 42.34 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">75,682,646 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">75,807,592 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000112175">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">Achilles tendon</li><br /><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">cartilage tissue</li><br /><li style="line-height: 137%;">tibia</li><br /><li style="line-height: 137%;">placenta</li><br /><li style="line-height: 137%;">Epithelium of choroid plexus</li><br /><li style="line-height: 137%;">mucosa of urinary bladder</li><br /><li style="line-height: 137%;">rectum</li><br /><li style="line-height: 137%;">jejunal mucosa</li><br /><li style="line-height: 137%;">right lung</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000032179">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">zygote</li><br /><li style="line-height: 137%;">primary oocyte</li><br /><li style="line-height: 137%;">vestibular sensory epithelium</li><br /><li style="line-height: 137%;">left lung lobe</li><br /><li style="line-height: 137%;">vestibular membrane of cochlear duct</li><br /><li style="line-height: 137%;">Paneth cell</li><br /><li style="line-height: 137%;">skin of external ear</li><br /><li style="line-height: 137%;">carotid body</li><br /><li style="line-height: 137%;">right lung</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000112175">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_BMP5_205431_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e1/PBB_GE_BMP5_205431_s_at_fs.png/250px-PBB_GE_BMP5_205431_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e1/PBB_GE_BMP5_205431_s_at_fs.png/375px-PBB_GE_BMP5_205431_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e1/PBB_GE_BMP5_205431_s_at_fs.png/500px-PBB_GE_BMP5_205431_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_BMP5_205430_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/66/PBB_GE_BMP5_205430_at_fs.png/250px-PBB_GE_BMP5_205430_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/66/PBB_GE_BMP5_205430_at_fs.png/375px-PBB_GE_BMP5_205430_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/66/PBB_GE_BMP5_205430_at_fs.png/500px-PBB_GE_BMP5_205430_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/653/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005125">cytokine activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070700">BMP receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005160">transforming growth factor beta receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008083">growth factor activity</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031982">vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005575">cellular component</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042981">regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007389">pattern specification process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001501">skeletal system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030539">male genitalia development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043408">regulation of MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060395">SMAD protein signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001503">ossification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050679">positive regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071676">negative regulation of mononuclear cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000065">negative regulation of cortisol biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010862">positive regulation of pathway-restricted SMAD protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900006">positive regulation of dendrite development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030509">BMP signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007275">multicellular organism development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051216">cartilage development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902042">negative regulation of extrinsic apoptotic signaling pathway via death domain receptors</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043569">negative regulation of insulin-like growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003323">type B pancreatic cell development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010894">negative regulation of steroid biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010719">negative regulation of epithelial to mesenchymal transition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008285">negative regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032348">negative regulation of aldosterone biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003272">endocardial cushion formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003344">pericardium morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021502">neural fold elevation formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030902">hindbrain development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048738">cardiac muscle tissue development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060037">pharyngeal system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060411">cardiac septum morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060710">chorio-allantoic fusion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061384">heart trabecula morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905069">allantois development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043583">ear development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097065">anterior head development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048468">cell development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=653&rn=1">653</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=12160&rn=1">12160</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000112175;db=core">ENSG00000112175</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000032179;db=core">ENSMUSG00000032179</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P22003">P22003</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P49003">P49003</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_021073">NM_021073</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001329754">NM_001329754</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001329756">NM_001329756</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_007555">NM_007555</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001316683">NP_001316683</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001316685">NP_001316685</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_066551">NP_066551</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_066551.1">NP_066551.1</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_031581">NP_031581</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr6:55753653-55875590">Chr 6: 55.75 – 55.88 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr9:75682646-75807592">Chr 9: 75.68 – 75.81 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14903759" class="extiw" title="d:Q14903759">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14903760" class="extiw" title="d:Q14903760">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Bone morphogenetic protein 5</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>BMP5</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1427904_5-0" class="reference"><a href="#cite_note-pmid1427904-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11580864_6-0" class="reference"><a href="#cite_note-pmid11580864-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>The <a href="/wiki/Protein" title="Protein">protein</a> encoded by this gene is member of the <a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> superfamily. <a href="/wiki/Bone_morphogenetic_proteins" class="mw-redirect" title="Bone morphogenetic proteins">Bone morphogenetic proteins</a> are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain <a href="/wiki/Cancer" title="Cancer">cancers</a>. Like other BMP's BMP5 is inhibited by <a href="/wiki/Chordin" title="Chordin">chordin</a> and <a href="/wiki/Noggin_(protein)" title="Noggin (protein)">noggin</a>. It is expressed in the <a href="/wiki/Trabecular_meshwork" title="Trabecular meshwork">trabecular meshwork</a> and <a href="/wiki/Optic_nerve_head" class="mw-redirect" title="Optic nerve head">optic nerve head</a> and may have a role in the development and normal function. It is also expressed in the <a href="/wiki/Lung" title="Lung">lung</a> and <a href="/wiki/Liver" title="Liver">liver</a>. </p><p>This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized <a href="/w/index.php?title=Bone_extract&action=edit&redlink=1" class="new" title="Bone extract (page does not exist)">bone extract</a> to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bone_morphogenetic_protein_5&action=edit&section=1" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000112175">GRCh38: Ensembl release 89: ENSG00000112175</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000032179">GRCm38: Ensembl release 89: ENSMUSG00000032179</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=653">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D653&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABone+morphogenetic+protein+5" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=12160">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D12160&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABone+morphogenetic+protein+5" class="Z3988"></span></span> </li> <li id="cite_note-pmid1427904-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1427904_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHahnCohenWozneyLevitz1992" class="citation journal cs1">Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0888-7543%2805%2980181-8">"A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7"</a>. <i>Genomics</i>. <b>14</b> (3): 759–62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0888-7543%2805%2980181-8">10.1016/S0888-7543(05)80181-8</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1427904">1427904</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=A+bone+morphogenetic+protein+subfamily%3A+chromosomal+localization+of+human+genes+for+BMP5%2C+BMP6%2C+and+BMP7&rft.volume=14&rft.issue=3&rft.pages=759-62&rft.date=1992-11&rft_id=info%3Adoi%2F10.1016%2FS0888-7543%2805%2980181-8&rft_id=info%3Apmid%2F1427904&rft.aulast=Hahn&rft.aufirst=GV&rft.au=Cohen%2C+RB&rft.au=Wozney%2C+JM&rft.au=Levitz%2C+CL&rft.au=Shore%2C+EM&rft.au=Zasloff%2C+MA&rft.au=Kaplan%2C+FS&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0888-7543%252805%252980181-8&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABone+morphogenetic+protein+5" class="Z3988"></span></span> </li> <li id="cite_note-pmid11580864-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11580864_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBeckDrahushukJacobyHiggins2003" class="citation journal cs1">Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC56999">"Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons"</a>. <i>BMC Neuroscience</i>. <b>2</b>: 12. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1471-2202-2-12">10.1186/1471-2202-2-12</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC56999">56999</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11580864">11580864</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMC+Neuroscience&rft.atitle=Bone+morphogenetic+protein-5+%28BMP-5%29+promotes+dendritic+growth+in+cultured+sympathetic+neurons&rft.volume=2&rft.pages=12&rft.date=2003-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC56999%23id-name%3DPMC&rft_id=info%3Apmid%2F11580864&rft_id=info%3Adoi%2F10.1186%2F1471-2202-2-12&rft.aulast=Beck&rft.aufirst=HN&rft.au=Drahushuk%2C+K&rft.au=Jacoby%2C+DB&rft.au=Higgins%2C+D&rft.au=Lein%2C+PJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC56999&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABone+morphogenetic+protein+5" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=653">"Entrez Gene: BMP5 bone morphogenetic protein 5"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+BMP5+bone+morphogenetic+protein+5&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D653&rfr_id=info%3Asid%2Fen.wikipedia.org%3ABone+morphogenetic+protein+5" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bone_morphogenetic_protein_5&action=edit&section=2" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=BMP5"><i>BMP5</i></a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=BMP5"><i>BMP5</i></a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Bone_morphogenetic_protein_5&action=edit&section=3" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCelesteIannazziTaylorHewick1990" class="citation journal cs1">Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55270">"Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>87</b> (24): 9843–7. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1990PNAS...87.9843C">1990PNAS...87.9843C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.87.24.9843">10.1073/pnas.87.24.9843</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55270">55270</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2263636">2263636</a>.</cite><span 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id="CITEREFWilkinsSouthamPriceMustafa2007" class="citation journal cs1">Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2Fddl488">"Extreme context specificity in differential allelic expression"</a>. <i>Human Molecular Genetics</i>. <b>16</b> (5): 537–46. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fhmg%2Fddl488">10.1093/hmg/ddl488</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17220169">17220169</a>.</cite><span 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ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:TGF_beta_signaling" title="Template:TGF beta signaling"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:TGF_beta_signaling" title="Template talk:TGF beta signaling"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:TGF_beta_signaling" title="Special:EditPage/Template:TGF beta signaling"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_signaling:_TGFβ_signaling_pathway" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_signaling" title="Cell signaling">Cell signaling</a>: <a href="/wiki/TGF%CE%B2_signaling_pathway" class="mw-redirect" title="TGFβ signaling pathway">TGFβ signaling pathway</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Transforming_growth_factor_beta_superfamily" title="Transforming growth factor beta superfamily">TGF beta superfamily of ligands</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Ligand of <a href="/wiki/Activin_receptor" title="Activin receptor">ACVR</a> or <a href="/wiki/TGF_beta_receptor" title="TGF beta receptor">TGFBR</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGF beta family</a> <ul><li><a href="/wiki/TGF_beta_1" title="TGF beta 1">TGF-β1</a></li> <li><a href="/wiki/TGF_beta_2" title="TGF beta 2">TGF-β2</a></li> <li><a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">TGF-β3</a></li></ul></li> <li><a href="/wiki/Activin_and_inhibin" title="Activin and inhibin">Activin and inhibin</a> <ul><li><a href="/wiki/INHA" title="INHA">INHA</a></li> <li><a href="/wiki/INHBA" title="INHBA">INHBA</a></li> <li><a href="/wiki/INHBB" title="INHBB">INHBB</a></li> <li><a href="/wiki/INHBC" title="INHBC">INHBC</a></li></ul></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Ligand of <a href="/wiki/Bone_morphogenetic_protein_receptor" title="Bone morphogenetic protein receptor">BMPR</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">Bone morphogenetic proteins</a> <ul><li><a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">BMP2</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_3" title="Bone morphogenetic protein 3">BMP3</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_4" title="Bone morphogenetic protein 4">BMP4</a></li> <li><a class="mw-selflink selflink">BMP5</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_6" title="Bone morphogenetic protein 6">BMP6</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_7" title="Bone morphogenetic protein 7">BMP7</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_8A" title="Bone morphogenetic protein 8A">BMP8a</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_8b" class="mw-redirect" title="Bone morphogenetic protein 8b">BMP8b</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_10" title="Bone morphogenetic protein 10">BMP10</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_15" title="Bone morphogenetic protein 15">BMP15</a></li></ul></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">Growth differentiation factors</a> <ul><li><a href="/wiki/GDF1" title="GDF1">GDF1</a></li> <li><a href="/wiki/GDF2" title="GDF2">GDF2</a></li> <li><a href="/wiki/GDF3" title="GDF3">GDF3</a></li> <li><a href="/wiki/GDF5" title="GDF5">GDF5</a></li> <li><a href="/wiki/GDF6" title="GDF6">GDF6</a></li> <li><a href="/wiki/GDF7" title="GDF7">GDF7</a></li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin/GDF8</a></li> <li><a href="/wiki/Growth_differentiation_factor-9" title="Growth differentiation factor-9">GDF9</a></li> <li><a href="/wiki/GDF10" title="GDF10">GDF10</a></li> <li><a href="/wiki/GDF11" title="GDF11">GDF11</a></li> <li><a href="/wiki/GDF15" title="GDF15">GDF15</a></li></ul></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">Anti-müllerian hormone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/TGF_beta_receptors" class="mw-redirect" title="TGF beta receptors">TGF beta receptors</a><br />(<a href="/wiki/Activin_receptor" title="Activin receptor">Activin</a>, <a href="/wiki/Bone_morphogenetic_protein_receptors" class="mw-redirect" title="Bone morphogenetic protein receptors">BMP</a>, <a href="/wiki/TGF-beta_receptor_family" title="TGF-beta receptor family">family</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR1:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_type_1_receptors" title="Activin type 1 receptors">Activin type 1 receptors</a> <ul><li><a href="/wiki/ACVR1" title="ACVR1">ACVR1</a></li> <li><a href="/wiki/ACVR1B" title="ACVR1B">ACVR1B</a></li> <li><a href="/wiki/ACVR1C" title="ACVR1C">ACVR1C</a></li></ul></li> <li><a href="/wiki/ACVRL1" title="ACVRL1">ACVRL1</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_receptor,_type_1" title="Bone morphogenetic protein receptor, type 1">BMPR1</a> <ul><li><a href="/wiki/BMPR1A" title="BMPR1A">BMPR1A</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">BMPR1B</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR2:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activin_type_2_receptors" title="Activin type 2 receptors">Activin type 2 receptors</a> <ul><li><a href="/wiki/ACVR2A" title="ACVR2A">ACVR2A</a></li> <li><a href="/wiki/ACVR2B" title="ACVR2B">ACVR2B</a></li></ul></li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone_receptor" title="Anti-Müllerian hormone receptor">AMHR2</a></li> <li><a href="/wiki/BMPR2" title="BMPR2">BMPR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">TGFBR3:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Betaglycan" class="mw-redirect" title="Betaglycan">betaglycan</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Signal_transduction" title="Signal transduction">Transducers</a>/<a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> (<a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">SMAD1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">SMAD2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">SMAD3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">SMAD5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">SMAD9</a>)</li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> (<a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">SMAD6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">SMAD7</a>)</li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">SMAD4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/TGF_beta_signaling_pathway#Ligand_agonists.2Fantagonists" title="TGF beta signaling pathway">Ligand inhibitors</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cerberus_(protein)" title="Cerberus (protein)">Cerberus</a></li> <li><a href="/wiki/Chordin" title="Chordin">Chordin</a></li> <li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Follistatin" title="Follistatin">Follistatin</a></li> <li><a href="/wiki/Gremlin_(protein)" title="Gremlin (protein)">Gremlin</a></li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a></li> <li><a href="/wiki/Latent_TGF-beta_binding_protein" title="Latent TGF-beta binding protein">LTBP1</a></li> <li><a href="/wiki/Noggin_(protein)" title="Noggin (protein)">Noggin</a></li> <li><a href="/wiki/Poly(A)-specific_ribonuclease" title="Poly(A)-specific ribonuclease">PARN</a></li> <li><a href="/wiki/Thrombospondin_1" title="Thrombospondin 1">THBS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Co-receptor" title="Co-receptor">Coreceptors</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BAMBI" title="BAMBI">BAMBI</a></li> <li><a href="/wiki/Cripto" title="Cripto">Cripto</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Zinc_finger_FYVE_domain-containing_protein_9" title="Zinc finger FYVE domain-containing protein 9">SARA</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="TGFβ_receptor_superfamily_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:TGF%CE%B2_receptor_superfamily_modulators" title="Template talk:TGFβ receptor superfamily modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Special:EditPage/Template:TGFβ receptor superfamily modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="TGFβ_receptor_superfamily_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/TGF%CE%B2_receptor_superfamily" class="mw-redirect" title="TGFβ receptor superfamily"><abbr title="Transforming growth factor beta">TGFβ</abbr> receptor superfamily</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_I" class="mw-redirect" title="TGFβ superfamily receptor">Type I</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK1" class="mw-redirect" title="ALK1"><abbr title="Activin receptor-like kinase 1">ALK1</abbr> (<abbr title="Activin A receptor-like type 1">ACVRL1</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/BMP10" class="mw-redirect" title="BMP10">10</a>)</li> <li><a href="/w/index.php?title=Cetermin&action=edit&redlink=1" class="new" title="Cetermin (page does not exist)">Cetermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF2" title="GDF2">2 (BMP9)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ascrinvacumab" title="Ascrinvacumab">Ascrinvacumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li> <li><a href="/w/index.php?title=ML-347&action=edit&redlink=1" class="new" title="ML-347 (page does not exist)">ML-347 (LDN-193719, VU0469381)</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Dalantercept" class="mw-redirect" title="Dalantercept">Dalantercept</a></li></ul> <ul><li><i>Other inhibitors:</i> <a href="/w/index.php?title=Disitertide&action=edit&redlink=1" class="new" title="Disitertide (page does not exist)">Disitertide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK2" class="mw-redirect" title="ALK2"><abbr title="Activin receptor-like kinase 2">ALK2</abbr> (<abbr title="Activin A receptor type 1A">ACVR1A</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li> <li><a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>)</li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-1&action=edit&redlink=1" class="new" title="DMH-1 (page does not exist)">DMH-1</a></li> <li><a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li> <li><a href="/w/index.php?title=ML-347&action=edit&redlink=1" class="new" title="ML-347 (page does not exist)">ML-347 (LDN-193719, VU0469381)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK3" class="mw-redirect" title="ALK3"><abbr title="Activin receptor-like kinase 3">ALK3</abbr> (<abbr title="Bone morphogenetic protein receptor type 1A">BMPR1A</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK4" class="mw-redirect" title="ALK4"><abbr title="Activin receptor-like kinase 4">ALK4</abbr> (<abbr title="Activin A receptor type 1B">ACVR1B</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK5" class="mw-redirect" title="ALK5"><abbr title="Activin receptor-like kinase 5">ALK5</abbr> (<abbr title="Transforming growth factor beta receptor 1">TGFβR1</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF10" title="GDF10">10 (BMP3B)</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/w/index.php?title=D-4476&action=edit&redlink=1" class="new" title="D-4476 (page does not exist)">D-4476</a></li> <li><a href="/w/index.php?title=GW-788388&action=edit&redlink=1" class="new" title="GW-788388 (page does not exist)">GW-788388</a></li> <li><a href="/w/index.php?title=LY-364947&action=edit&redlink=1" class="new" title="LY-364947 (page does not exist)">LY-364947</a></li> <li><a href="/wiki/LY-2109761" title="LY-2109761">LY-2109761</a></li> <li><a href="/wiki/Galunisertib" title="Galunisertib">Galunisertib (LY-2157299)</a></li> <li><a href="/w/index.php?title=R-268712&action=edit&redlink=1" class="new" title="R-268712 (page does not exist)">R-268712</a></li> <li><a href="/wiki/RepSox" title="RepSox">RepSox (E-616452, SJN-2511)</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li> <li><a href="/w/index.php?title=SB-525334&action=edit&redlink=1" class="new" title="SB-525334 (page does not exist)">SB-525334</a></li> <li><a href="/w/index.php?title=SD-208&action=edit&redlink=1" class="new" title="SD-208 (page does not exist)">SD-208</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK6" class="mw-redirect" title="ALK6"><abbr title="Activin receptor-like kinase 6">ALK6</abbr> (<abbr title="Bone morphogenetic protein receptor type 1B">BMPR1B</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>, <a href="/wiki/BMP15" class="mw-redirect" title="BMP15">15 (GDF9B)</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>, <a href="/wiki/GDF9" class="mw-redirect" title="GDF9">9</a>, <a href="/wiki/GDF15" title="GDF15">15</a>)</li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=Dorsomorphin&action=edit&redlink=1" class="new" title="Dorsomorphin (page does not exist)">Dorsomorphin (BML-275)</a></li> <li><a href="/w/index.php?title=K-02288&action=edit&redlink=1" class="new" title="K-02288 (page does not exist)">K-02288</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ALK7" class="mw-redirect" title="ALK7"><abbr title="Activin receptor-like kinase 7">ALK7</abbr> (<abbr title="Activin A receptor type 1C">ACVR1C</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>)</li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=A_83-01&action=edit&redlink=1" class="new" title="A 83-01 (page does not exist)">A 83-01</a></li> <li><a href="/wiki/SB-431542" title="SB-431542">SB-431542</a></li> <li><a href="/w/index.php?title=SB-505124&action=edit&redlink=1" class="new" title="SB-505124 (page does not exist)">SB-505124</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_II" class="mw-redirect" title="TGFβ superfamily receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/TGF%CE%B2R2" class="mw-redirect" title="TGFβR2"><abbr title="Transforming growth factor beta receptor 2">TGFβR2</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF10" title="GDF10">10 (BMP3B)</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fresolimumab" title="Fresolimumab">Fresolimumab</a></li> <li><a href="/wiki/Lerdelimumab" title="Lerdelimumab">Lerdelimumab</a></li> <li><a href="/wiki/Metelimumab" title="Metelimumab">Metelimumab</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=DMH-2&action=edit&redlink=1" class="new" title="DMH-2 (page does not exist)">DMH-2</a></li> <li><a href="/w/index.php?title=LY-364947&action=edit&redlink=1" class="new" title="LY-364947 (page does not exist)">LY-364947</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/BMPR2" title="BMPR2"><abbr title="Bone morphogenetic protein receptor type 2">BMPR2</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP10" class="mw-redirect" title="BMP10">10</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF2" title="GDF2">2 (BMP9)</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>)</li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ACVR2A" title="ACVR2A"><abbr title="Activin receptor type 2A">ACVR2A</abbr> (<abbr title="Activin receptor type 2">ACVR2</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP5" class="mw-redirect" title="BMP5">5</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>, <a href="/wiki/BMP8A" class="mw-redirect" title="BMP8A">8A</a>, <a href="/wiki/BMP8B" class="mw-redirect" title="BMP8B">8B</a>, <a href="/wiki/BMP15" class="mw-redirect" title="BMP15">15 (GDF9B)</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>, <a href="/wiki/GDF9" class="mw-redirect" title="GDF9">9</a>, <a href="/wiki/GDF11" title="GDF11">11 (BMP11)</a>, <a href="/wiki/GDF15" title="GDF15">15</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Sotatercept" title="Sotatercept">Sotatercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/ACVR2A" title="ACVR2A"><abbr title="Activin receptor type 2B">ACVR2B</abbr></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Activin" class="mw-redirect" title="Activin">Activin</a> (<a href="/wiki/Activin_A" class="mw-redirect" title="Activin A">A</a>, <a href="/wiki/Activin_B" class="mw-redirect" title="Activin B">B</a>, <a href="/wiki/Activin_AB" class="mw-redirect" title="Activin AB">AB</a>)</li> <li><a href="/wiki/Bone_morphogenetic_protein" title="Bone morphogenetic protein">BMP</a> (<a href="/wiki/Bone_morphogenetic_protein_2" title="Bone morphogenetic protein 2">2</a>, <a href="/wiki/BMP4" class="mw-redirect" title="BMP4">4</a>, <a href="/wiki/BMP6" class="mw-redirect" title="BMP6">6</a>, <a href="/wiki/BMP7" class="mw-redirect" title="BMP7">7</a>)</li> <li><a href="/wiki/Dibotermin_alfa" class="mw-redirect" title="Dibotermin alfa">Dibotermin alfa</a></li> <li><a href="/wiki/Eptotermin_alfa" class="mw-redirect" title="Eptotermin alfa">Eptotermin alfa</a></li> <li><a href="/wiki/Growth_differentiation_factor" title="Growth differentiation factor">GDF</a> (<a href="/wiki/GDF1" title="GDF1">1</a>, <a href="/wiki/GDF3" title="GDF3">3</a>, <a href="/wiki/GDF5" title="GDF5">5 (BMP14)</a>, <a href="/wiki/GDF6" title="GDF6">6 (BMP13)</a>, <a href="/wiki/GDF7" title="GDF7">7 (BMP12)</a>)</li> <li><a href="/wiki/Myostatin" title="Myostatin">Myostatin (GDF8)</a></li> <li><a href="/wiki/NODAL" class="mw-redirect" title="NODAL">Nodal</a></li> <li><a href="/wiki/Bone_morphogenetic_protein_3" title="Bone morphogenetic protein 3">Osteogenin (BMP3, BMP3A)</a></li> <li><a href="/w/index.php?title=Radotermin&action=edit&redlink=1" class="new" title="Radotermin (page does not exist)">Radotermin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Lefty_(protein)" title="Lefty (protein)">Lefty</a> (<a href="/wiki/LEFTY1" class="mw-redirect" title="LEFTY1">1</a>, <a href="/wiki/LEFTY2" title="LEFTY2">2</a>)</li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=Ramatercept&action=edit&redlink=1" class="new" title="Ramatercept (page does not exist)">Ramatercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/AMHR2" class="mw-redirect" title="AMHR2"><abbr title="Anti-Müllerian hormone receptor type 2">AMHR2</abbr> (<abbr title="Anti-Müllerian hormone receptor">AMHR</abbr>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Anti-M%C3%BCllerian_hormone" title="Anti-Müllerian hormone">AMH (MIS)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TGF%CE%B2_superfamily_receptor#Type_III" class="mw-redirect" title="TGFβ superfamily receptor">Type III</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TGFβR3_(β-glycan)" scope="row" class="navbox-group" style="width:9em;;text-align:center;"><a href="/wiki/TGF%CE%B2R3" class="mw-redirect" title="TGFβR3"><abbr title="Transforming growth factor beta receptor 3">TGFβR3</abbr> (β-glycan)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Ligands:</i> <a href="/wiki/Avotermin" class="mw-redirect" title="Avotermin">Avotermin</a></li> <li><a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a> (<a href="/wiki/Inhibin_A" class="mw-redirect" title="Inhibin A">A</a>, <a href="/wiki/Inhibin_B" class="mw-redirect" title="Inhibin B">B</a>)</li> <li><a href="/wiki/Transforming_growth_factor_beta" title="Transforming growth factor beta">TGFβ</a> (<a href="/wiki/TGF_beta_1" title="TGF beta 1">1</a>, <a href="/wiki/TGF_beta_2" title="TGF beta 2">2</a>, <a href="/wiki/TGF_beta_3" class="mw-redirect" title="TGF beta 3">3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Endogenous antagonists/inhibitors:</i> <a href="/wiki/BAMBI" title="BAMBI">BAMBI</a></li> <li><a href="/wiki/Cerberus_(protein)" title="Cerberus (protein)">Cerberus (CER1)</a></li> <li><a href="/wiki/Chordin" title="Chordin">Chordin</a></li> <li><a href="/wiki/DAN_(protein)" class="mw-redirect" title="DAN (protein)">DAN (PARN)</a></li> <li><a href="/wiki/Decorin" title="Decorin">Decorin</a></li> <li><a href="/wiki/Follistatin" title="Follistatin">Follistatin</a></li> <li><a href="/wiki/Gremlin_(protein)" title="Gremlin (protein)">Gremlin (Drm)</a></li> <li><a href="/wiki/LTBP1_(gene)" title="LTBP1 (gene)">LTBP1</a></li> <li><a href="/wiki/Noggin_(protein)" title="Noggin (protein)">Noggin</a></li> <li><a href="/wiki/Transforming_growth_interacting_factor" title="Transforming growth interacting factor">TGIF</a></li> <li><a href="/wiki/Thrombospondin_1" title="Thrombospondin 1">Thrombospondin 1 (THBS1)</a></li> <li><a href="/w/index.php?title=Tomoregulin_1&action=edit&redlink=1" class="new" title="Tomoregulin 1 (page does not exist)">Tomoregulin 1</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Stamulumab" title="Stamulumab">Stamulumab</a> (against myostatin)</li> <li><a href="/wiki/TRC105" class="mw-redirect" title="TRC105">TRC105</a> (against endoglin)</li></ul> <ul><li><i>Others:</i> <a href="/wiki/Endoglin" title="Endoglin">Endoglin</a></li></ul> </div></td></tr></tbody></table></div> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" 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