Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation

<!DOCTYPE html> <html lang="zh-cn"> <head> <link rel="dns-prefetch" href="//www.peeref.com"> <link rel="dns-prefetch" href="//peeref-open.s3.amazonaws.com"> <link rel="dns-prefetch" href="//www.w3.org"> <link rel="dns-prefetch" href="//doi.org"> <link rel="dns-prefetch" href="//www.linkedin.com"> <link rel="dns-prefetch" href="//twitter.com"> <link rel="dns-prefetch" href="//api.qrserver.com"> <link rel="dns-prefetch" href="//www.facebook.com"> <link rel="dns-prefetch" href="//www.googletagmanager.com"> <meta charset="utf-8"> <title>Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation - Peeref</title> <meta http-equiv="X-UA-Compatible" content="IE=edge, chrome=1"> <meta name="keywords" content="文章、文章评论、研究论文"> <meta name="description" content=""> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="viewport" content="width=device-width, initial-scale=1.0, maximum-scale=1.0, user-scalable=no" /> <meta property="og:locale" content="zh"> <meta property="og:title" content="Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation - Peeref"> <meta property="og:description" content=""> <meta property="og:url" content="https://www.peeref.com/zh/works/82557507"> <meta property="og:site_name" content="Peeref"> <meta property="og:image" content=""> <meta name="csrf-token" content="FCR7xmHOOdyMSfyKGu7mSTzBHAvLOn38RDqbyytO"> <meta http-equiv="Cache-Control" content="no-transform" /> <meta http-equiv="Cache-Control" content="no-siteapp" /> <link rel="shortcut icon" href="https://www.peeref.com/favicon.ico"> <link href="https://peeref-open.s3.amazonaws.com/css/frameworks.bd380c8996823ba04442.css" rel="stylesheet"> <link href="https://peeref-open.s3.amazonaws.com/css/app.3cfd9992ceaf352e0491.css" rel="stylesheet"> <script> if(window.self !== window.top) { location.href = '/static/html/forbidden.html'; } </script> <script> window.Config = { token: "FCR7xmHOOdyMSfyKGu7mSTzBHAvLOn38RDqbyytO", url: "https://www.peeref.com/zh/works/82557507", lang: "zh", prefix: "/zh", isMobile: "", assetDomain: "https://peeref-open.s3.amazonaws.com/" }; </script> </head> <body> <div id="app"> <div class="bg-warning position-relative w-100 text-center py-2" style="top: 0; z-index: 100000;"> <strong class="text-danger">Peeref no longer supports Internet Explorer. </strong> <a href="/static/html/browser.html">Please upgrade your browser.</a> </div> <nav id="nav" class="navbar navbar-default navbar-static-top navbar-inverse"> <div class="container"> <div class="navbar-header"> <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#app-navbar-collapse" aria-expanded="false"> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> <a class="navbar-brand p-3" href="https://www.peeref.com/zh"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="108px" viewBox="0 0 1052 302"><g fill="#FFF"><path d="M227.6,92.9c5.2,13,17.9,22.1,32.7,22.1c19.4,0,35.2-15.8,35.2-35.2s-15.8-35.2-35.2-35.2 c-19.4,0-35.2,15.8-35.2,35.2c0,2.3,0.2,4.5,0.6,6.7l-98.1,24.6L154,59c3.2,1.1,6.6,1.8,10.1,1.8c16.4,0,29.7-13.3,29.7-29.7c0-16.4-13.3-29.7-29.7-29.7s-29.7,13.3-29.7,29.7c0,10.5,5.4,19.7,13.6,25l-27.9,55.1L90.5,94.2c1.4-3.2,2.1-6.8,2.1-10.6 c0-14.9-12.1-27-27-27c-14.9,0-27,12.1-27,27c0,14.9,12.1,27,27,27c8.8,0,16.6-4.2,21.6-10.7l28.5,16.3l-62.2,49.9 c-5.6-5.3-13.1-8.6-21.4-8.6c-17.1,0-30.9,13.8-30.9,30.9c0,17.1,13.8,30.9,30.9,30.9S63,205.4,63,188.4c0-6.3-1.9-12.3-5.2-17.2 l60-48.1l-7.5,106.4c-19.1,0.6-34.4,16.2-34.4,35.5c0,19.6,15.9,35.5,35.5,35.5c19.6,0,35.5-15.9,35.5-35.5c0-17.7-13-32.4-30-35.1 l7.6-107.5l87,67.9c-4.1,6.1-6.4,13.5-6.4,21.4c0,21.4,17.4,38.8,38.8,38.8s38.8-17.4,38.8-38.8c0-21.4-17.4-38.8-38.8-38.8 c-11.1,0-21.2,4.7-28.2,12.2L129,117.6L227.6,92.9z"></path></g><g fill="#FFF"><path d="M368.2,232.3V70.6h52.4c19.9,0,32.8,0.8,38.8,2.4c9.3,2.4,17,7.7,23.3,15.8c6.2,8.1,9.4,18.6,9.4,31.5c0,9.9-1.8,18.3-5.4,25c-3.6,6.8-8.2,12.1-13.7,15.9c-5.6,3.9-11.2,6.4-16.9,7.7c-7.8,1.5-19.1,2.3-33.9,2.3h-21.3v61H368.2z M400.8,98v45.9h17.9c12.9,0,21.5-0.8,25.8-2.5c4.3-1.7,7.7-4.3,10.2-7.9c2.5-3.6,3.7-7.8,3.7-12.6c0-5.9-1.7-10.7-5.2-14.6c-3.5-3.8-7.8-6.2-13.1-7.2c-3.9-0.7-11.7-1.1-23.5-1.1H400.8z"></path><path d="M586.5,195l30.9,5.2c-4,11.3-10.2,19.9-18.8,25.9c-8.6,5.9-19.3,8.9-32.2,8.9c-20.4,0-35.4-6.7-45.2-20c-7.7-10.7-11.6-24.1-11.6-40.4c0-19.4,5.1-34.6,15.2-45.6c10.1-11,23-16.5,38.5-16.5c17.4,0,31.2,5.8,41.3,17.3c10.1,11.5,14.9,29.1,14.5,52.9h-77.7c0.2,9.2,2.7,16.3,7.5,21.5c4.8,5.1,10.7,7.7,17.9,7.7c4.9,0,8.9-1.3,12.2-4S584.8,200.9,586.5,195z M588.3,163.7c-0.2-9-2.5-15.8-6.9-20.5c-4.4-4.7-9.8-7-16.1-7c-6.8,0-12.4,2.5-16.8,7.4c-4.4,4.9-6.6,11.6-6.5,20.1H588.3z"></path><path d="M712.2,195l30.9,5.2c-4,11.3-10.2,19.9-18.8,25.9c-8.6,5.9-19.3,8.9-32.2,8.9c-20.4,0-35.4-6.7-45.2-20c-7.7-10.7-11.6-24.1-11.6-40.4c0-19.4,5.1-34.6,15.2-45.6c10.1-11,23-16.5,38.5-16.5c17.4,0,31.2,5.8,41.3,17.3c10.1,11.5,14.9,29.1,14.5,52.9H667c0.2,9.2,2.7,16.3,7.5,21.5c4.8,5.1,10.7,7.7,17.9,7.7c4.9,0,8.9-1.3,12.2-4S710.5,200.9,712.2,195z M713.9,163.7c-0.2-9-2.5-15.8-6.9-20.5c-4.4-4.7-9.8-7-16.1-7c-6.8,0-12.4,2.5-16.8,7.4c-4.4,4.9-6.6,11.6-6.5,20.1H713.9z"></path><path d="M799.6,232.3h-31V115.2h28.8v16.7c4.9-7.9,9.4-13.1,13.3-15.6c3.9-2.5,8.4-3.8,13.4-3.8c7.1,0,13.9,1.9,20.4,5.8l-9.6,27c-5.2-3.4-10.1-5.1-14.6-5.1c-4.3,0-8,1.2-11,3.6c-3,2.4-5.4,6.7-7.1,13c-1.7,6.3-2.6,19.3-2.6,39.3V232.3z"></path><path d="M925.7,195l30.9,5.2c-4,11.3-10.2,19.9-18.8,25.9c-8.6,5.9-19.3,8.9-32.2,8.9c-20.4,0-35.4-6.7-45.2-20c-7.7-10.7-11.6-24.1-11.6-40.4c0-19.4,5.1-34.6,15.2-45.6c10.1-11,23-16.5,38.5-16.5c17.4,0,31.2,5.8,41.3,17.3c10.1,11.5,14.9,29.1,14.5,52.9h-77.7c0.2,9.2,2.7,16.3,7.5,21.5c4.8,5.1,10.7,7.7,17.9,7.7c4.9,0,8.9-1.3,12.2-4S924,200.9,925.7,195z M927.5,163.7c-0.2-9-2.5-15.8-6.9-20.5c-4.4-4.7-9.8-7-16.1-7c-6.8,0-12.4,2.5-16.8,7.4c-4.4,4.9-6.6,11.6-6.5,20.1H927.5z"></path><path d="M970,115.2h17.2v-8.8c0-9.9,1-17.2,3.1-22.1c2.1-4.9,6-8.8,11.6-11.9c5.6-3.1,12.7-4.6,21.3-4.6c8.8,0,17.5,1.3,25.9,4l-4.2,21.6c-4.9-1.2-9.7-1.8-14.2-1.8c-4.5,0-7.7,1-9.7,3.1c-1.9,2.1-2.9,6.1-2.9,12.1v8.3h23.2v24.4h-23.2v92.8h-31v-92.8H970V115.2z"></path></g></svg> </a> </div> <ul class="collapse navbar-collapse mb-0" id="app-navbar-collapse"> <ul class="nav navbar-nav"> <li class="dropdown dropdown-hover"> <a href="javascript:">出版 <span class="caret"></span></a> <ul class="dropdown-menu dropdown-menu-inverse"> <li><a href="https://www.peeref.com/zh/posters">海报</a></li> <li><a href="https://www.peeref.com/zh/abstracts">摘要</a></li> </ul> </li> <li class="dropdown dropdown-hover"> <a href="javascript:">讨论 <span class="caret"></span></a> <ul class="dropdown-menu dropdown-menu-inverse"> <li><a href="https://www.peeref.com/zh/hubs">讨论圈</a></li> <li><a href="https://www.peeref.com/zh/questions">问题</a></li> </ul> </li> <li><a href="https://www.peeref.com/zh/works">论文</a></li> <li><a href="https://www.peeref.com/zh/webinars">研讨会</a></li> <li><a href="https://www.peeref.com/zh/funding">基金</a></li> <li class="dropdown dropdown-hover"> <a href="javascript:">出版工具 <span class="caret"></span></a> <ul class="dropdown-menu dropdown-menu-inverse"> <li><a href="https://www.peeref.com/zh/journals">期刊</a></li> <li><a href="https://www.peeref.com/zh/connect">科研社交</a></li> <li><a href="https://www.peeref.com/zh/e-collections">资讯集成</a></li> <li><a href="https://www.peeref.com/zh/reviewer">审稿人</a></li> </ul> </li> <li class="dropdown dropdown-hover"> <a href="javascript:">事件 <span class="caret"></span></a> <ul class="dropdown-menu dropdown-menu-inverse"> <li><a href="https://www.peeref.com/zh/poster-competition">Poster Challenger</a></li> <li><a href="https://www.peeref.com/zh/webinar-competition">Video Presentation</a></li> <li><a href="https://www.peeref.com/zh/artwork-competition">Art of Science</a></li> <li><a href="https://www.peeref.com/zh/events/reviewer-roulette">Reviewer Roulette</a></li> </ul> </li> </ul> <ul id="auth-menu" class="nav navbar-nav navbar-right" style="display: inline-flex; align-items: center;"> <li> <a href="https://www.peeref.com/zh/login"> <strong>我的账户</strong> </a> </li> </ul> <ul class="nav navbar-nav navbar-right" style="display: inline-flex; align-items: center; margin-left: 20px;"> <li id="language" class="d-none d-xl-inline-flex"> <a href="javascript:"> <div class="current"> <i class="ivu-icon ivu-icon-md-globe"></i> 中文 </div> </a> <div class="selection"> <a rel="alternate" hreflang="en" href="https://www.peeref.com/works/82557507" > <span>English</span> </a> <a rel="alternate" hreflang="zh" href="https://www.peeref.com/zh/works/82557507" > <span>中文</span> </a> </div> </li> </ul> </ul> </div> </nav> <main> <div id="top-info-banner" class="container-fluid mb-0"> <div class="container"> <div class="d-flex align-items-center" style="margin-top: 30px;"> <span class="text-white"> <strong class="f18">☆</strong> <span class="f16">4.8</span> </span> <span class="mx-3"></span> <span class="tag">Article</span> </div> <h1 class="title title-for-article"> Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation </h1> <div class="help-links-left"> <p class="pub-info"> ANALYTICAL CHEMISTRY (2024) </p> </div> </div> </div> <div id="article-sticky-navbar"> <div class="container"> <div class="d-flex justify-content-between flex-wrap flex-md-nowrap"> <div class="d-flex align-items-center mb-2"> <ul class="nav nav-underline f16 font-weight-bold"> <li class="active"> <a href="javascript:;"> 总览 </a> </li> <li class=""> <a href="https://www.peeref.com/zh/works/82557507/comments"> 撰写评论 </a> </li> </ul> </div> <div class="d-flex align-items-center justify-content-md-end flex-wrap flex-md-nowrap"> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <a href="https://doi.org/10.1021/acs.analchem.3c05006" target="_blank" class="btn btn-warning btn-circle"> <i class="ivu-icon ivu-icon-md-copy f16"></i> <strong>获取全文</strong> </a> </div> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <a href="https://www.peeref.com/zh/works/82557507/add-to-collection" class="btn btn-success btn-circle"> <strong>添加到收藏夹</strong> </a> </div> <div class="mr-3 mt-3 mt-md-0 flex-shrink-0"> <button class="btn btn-success btn-circle" id="reading-btn"> <strong>更多阅读</strong> </button> </div> <div class="flex-shrink-0 mt-3 mt-md-0"> <div class="dropdown"> <button class="font-weight-bold f24 ivu-btn ivu-btn-default ivu-btn-circle ivu-btn-large ivu-btn-icon-only dropdown-toggle" data-toggle="dropdown"> <i class="ivu-icon ivu-icon-md-more"></i> </button> <ul class="dropdown-menu dropdown-menu-right"> <li> <a href="#" data-target="#export-citation" data-toggle="modal"> <i class="ivu-icon ivu-icon-md-quote text-muted mr-1"></i> 导出引文 </a> </li> <li> <a href="#" data-target="#share-paper" data-toggle="modal"> <i class="ivu-icon ivu-icon-md-share-alt text-muted mr-1"></i> 分享论文 </a> </li> <li> <a href="https://www.peeref.com/zh/works/82557507/references"> <i class="ivu-icon ivu-icon-md-list text-muted mr-1"></i> 参考文献 </a> </li> </ul> </div> </div> </div> </div> </div> </div> <div id="article-details" class="container"> <div class="col-md-4 px-0 pr-md-3"> <div class="f15 panel-box rounded shadow-none border"> <div class="mb-3 pb-3"> <h4 class="mt-0">期刊</h4> <div class="f16"> <h5 class="title f16"> <a href="https://www.peeref.com/zh/journals/518/analytical-chemistry"> ANALYTICAL CHEMISTRY </a> </h5> <span> 卷 -, 期 -, 页码 - </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">出版社</h4> <div class="f16"> <h5 class="title f16 text-primary"> AMER CHEMICAL SOC </h5> <div class="my-2"> DOI: 10.1021/acs.analchem.3c05006 </div> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">关键词</h4> <div class="f16"> - </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">类别</h4> <div class="f16"> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Chemistry%2C+Analytical" target="_blank" class="text-dark btn btn-link p-0 text-left"> Chemistry, Analytical </a> </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">资金</h4> <div class="f16"> <ol class=""> <li>Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung</li> <li>SNSF [101017821]</li> <li>European Union's Horizon 2020 Research and Innovation program</li> </ol> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 text-center">向作者/读者索取更多资源</h4> <div class="requests"> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/file.png" alt=""> </div> <h4>Protocol</h4> <p> <a href="https://www.peeref.com/zh/works/82557507/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/experiment.png" alt=""> </div> <h4>Reagent</h4> <p> <a href="https://www.peeref.com/zh/works/82557507/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> </div> </div> </div> <div class="col-md-8 px-0 pl-md-3"> <div id="article-summary-panel" class="mb-4"> <ul class="nav nav-tabs" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#ai_summary" data-toggle="tab" class="summary-tab mx-0 f16 text-dark"> <strong>智能总结</strong> <strong class="text-danger ml-1"><i>New</i></strong> </a> </li> <li class=""> <a href="#raw_abstract" data-toggle="tab" class="abstract-tab mx-0 f16 text-dark"> <strong>摘要</strong> </a> </li> </ul> <div class="tab-content border border-top-0"> <div id="ai_summary" class="tab-pane active"> <div class="summary-panel panel-box mb-0 rounded shadow-none"> <div class="f16">This study presents a novel universal capillary-cell design for analytical ultracentrifugation-sedimentation equilibrium, which solves the problem of difficult and unreliable handling of existing research equipment and can be used to study high-concentration samples with a success rate close to 100%. The design creates a liquid reservoir on the bottom window of the AUC cell by laser ablation or mechanical drilling, which is easy to use, robust, reusable, and suitable for samples in aqueous and organic solvents. The study also demonstrates the practicality of the cell through experiments, including studying the equation of state and second virial coefficients of concentrated gold nanoparticle dispersions, the gelation phase transition of DNA and BSA solutions, and the liquid-liquid phase separation of concentrated BSA/PEG droplets.</div> </div> </div> <div id="raw_abstract" class="tab-pane "> <div class="abstract-panel panel-box mb-0 rounded shadow-none"> <div class="f16">In concentrated macromolecular dispersions, far-from-ideal intermolecular interactions determine the dispersion behaviors including phase transition, crystallization, and liquid-liquid phase separation. Here, we present a novel versatile capillary-cell design for analytical ultracentrifugation-sedimentation equilibrium (AUC-SE), ideal for studying samples at high concentrations. Current setups for such studies are difficult and unreliable to handle, leading to a low experimental success rate. The design presented here is easy to use, robust, and reusable for samples in both aqueous and organic solvents while requiring no special tools or chemical modification of AUC cells. The key and unique feature is the fabrication of liquid reservoirs directly on the bottom window of AUC cells, which can be easily realized by laser ablation or mechanical drilling. The channel length and optical path length are therefore tunable. The success rate for assembling this new cell is close to 100%. We demonstrate the practicality of this cell by studying: (1) the equation of state and second virial coefficients of concentrated gold nanoparticle dispersions in water and bovine serum albumin (BSA) as well as lysozyme solution in aqueous buffers, (2) the gelation phase transition of DNA and BSA solutions, and (3) liquid-liquid phase separation of concentrated BSA/polyethylene glycol (PEG) droplets.</div> </div> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">作者</h4> <div class="mb-3"> <article-authors tid="82557507" list="[{"name":"Quy Ong","sequence":1},{"name":"Xu Xufeng","sequence":2},{"name":"Francesco Stellacci","sequence":3}]" verified="[]" page="work" ></article-authors> </div> <div class="alert alert-warning mb-0"> <h5 class="mt-0 bg-warning text-dark px-3 rounded d-inline-block"> 我是这篇论文的作者 </h5> <div class="font-weight-bold f13"> 点击您的名字以认领此论文并将其添加到您的个人资料中。 </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">评论</h4> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="flex-grow-1"> <h4 class="f16"> 主要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="主要评分表示论文的整体质量水平。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap align-items-center alert mb-0"> <div class="d-flex align-items-center justify-content-center"> <Rate disabled allow-half value="4.8" style="font-size: 28px;"></Rate> <strong class="f20 m-3" style="color: #f5a623;">4.8</strong> </div> <div class="text-muted mx-4"> 评分不足 </div> </div> <h4 class="f16"> 次要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="次要评分独立反映论文的优点或缺点。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap alert"> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">新颖性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">重要性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">科学严谨性</h5> <strong class="mx-4">-</strong> </div> </div> </div> <div class="flex-shrink-0"> <div class="border bg-light py-2 px-4"> <h5 class="mb-1">评价这篇论文</h5> <Rate class="f24" @on-change="function(value){ location.href='https://www.peeref.com/zh/works/82557507/comments?rating='+value }"></Rate> </div> </div> </div> </div> <div id="collection" class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">推荐</h4> <div class="my-3"> <ul class="nav nav-pills border-bottom pb-3" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#articles_from_related" data-toggle="tab" class="mx-0 f15"> <strong>相关</strong> </a> </li> <li class=""> <a href="#articles_from_authors" data-toggle="tab" class="mx-0 f15"> <strong>来自同一作者</strong> </a> </li> <li class=""> <a href="#articles_from_journal" data-toggle="tab" class="mx-0 f15"> <strong>来自同一期刊</strong> </a> </li> </ul> <div class="tab-content"> <div id="articles_from_related" class="tab-pane active"> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Agriculture, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28453372" class="text-dark hover-underline">Analytical Ultracentrifugation-Calibrated Anion-Exchange Chromatography for Sensitive and Intact Determination of Osteopontin in Infant Formula and Dairy Products</a> </h4> <p class="text-ellipsis-2">Xiangxin Wang, Dongying Cui, Xueyin Qu, Hong You, Fan Lei, Jianqiao Li, Yang Xie, Haoshu Zhang, Yongjiu Zhang, Shilong Jiang, Qinggang Xie</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/4091.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed a novel anion-exchange chromatography method to determine the concentration of OPN in dairy products. The method showed low detection limits (0.04 mg/100 g), strong repeatability (relative standard deviation <5% for 13 out of 14 tested matrices), and high recovery rate (101.3%). This method has the potential to be adopted as an international standard method for the quantification of intact OPN in infant formula and dairy products. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28453372/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/26749436" class="text-dark hover-underline">Up-to-date knowledge about analytical methods for homocysteine thiolactone determination in biological samples</a> </h4> <p class="text-ellipsis-2">Justyna Piechocka, Rafal Glowacki</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7855.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This overview summarizes all documented analytical methods for the quantification of homocysteine thiolactone (HTL) in biological samples, with a focus on pre-analytical treatment strategies and separation techniques. The review also discusses the advantages, pitfalls, and limitations of the methods, as well as the origin and main metabolites of HTL, and the association between civilization diseases and sulfur-containing compounds' metabolism disorders. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">TRAC-TRENDS IN ANALYTICAL CHEMISTRY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/26749436/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84541151" class="text-dark hover-underline">3D-Printable Rotary Valves for Low-Pressure Pneumatic and Fluidic Applications in Analytical Chemistry</a> </h4> <p class="text-ellipsis-2">Tomas Drevinskas, Andrew Berg, Aaron C. Noell, Mauro S. Ferreira Santos, Maria F. Mora, Peter A. Willis</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/518.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This article presents a 3D-printed rotary valve made of high- or low-grade plastics, which is lightweight, integrable into chemical analysis systems, leak-proof, powered by a 5V supply, and controllable via USB or I2C. The cost of the valve, including electronics, is less than 100 USD when printed with high-grade plastics. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84541151/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28467834" class="text-dark hover-underline">On analytical theories for conductivity and self-diffusion in concentrated electrolytes</a> </h4> <p class="text-ellipsis-2">Olivier Bernard, Marie Jardat, Benjamin Rotenberg, Pierre Illien</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/4285.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Describing the transport properties of electrolytes has been a central challenge in chemical physics for almost a century. Stochastic Density Field Theory (SDFT) provides an analytical framework for approximating density correlations in fluctuating systems. This article discusses recent approximations for computing the conductivity and self-diffusion coefficient of electrolytes, comparing different approaches and their effects on the determination of electrolyte properties. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF CHEMICAL PHYSICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28467834/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/zh/works/24889835" class="text-dark hover-underline">Versatile strategy for homogeneous drying patterns of dispersed particles</a> </h4> <p class="text-ellipsis-2">Marcel Rey, Johannes Walter, Johannes Harrer, Carmen Morcillo Perez, Salvatore Chiera, Sharanya Nair, Maret Ickler, Alesa Fuchs, Mark Michaud, Maximilian J. Uttinger, Andrew B. Schofield, Job H. J. Thijssen, Monica Distaso, Wolfgang Peukert, Nicolas Vogel</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/8411.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Researchers have achieved homogeneous drying patterns and overcome the coffee ring effect by using surface-modified particle dispersions. This method is applicable to a wide range of materials and particle shapes. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NATURE COMMUNICATIONS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/24889835/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81819424" class="text-dark hover-underline">Saturation Equation: An Analytical Expression for Partial Saturation during Wicking Flow in Paper Microfluidic Channels</a> </h4> <p class="text-ellipsis-2">Satvik Verma, Bhushan J. Toley</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/5539.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper presents a simple and appropriate model of partial saturation in paper membranes, which models the paper membrane as a bundle of parallel capillaries with radii following a two-parameter log-normal distribution. By applying the Washburn equation, the distribution of fluid fronts can be calculated, and saturation can be calculated. The results of this model are in good agreement with experimental data and numerical results, and can be used for the design of paper microfluidic devices. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">LANGMUIR</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81819424/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/23280227" class="text-dark hover-underline">Evaluation of low-volume plasma sampling for the analysis of meropenem in clinical samples</a> </h4> <p class="text-ellipsis-2">Suzanne L. Parker, Steven C. Wallis, Cheryl Fourie, Melissa Lassig-Smith, Therese Starr, Avinash Chikatamarla, Tavey Dorofaeff, Mark D. Chatfield, Jeffrey Lipman, Jason A. Roberts</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/515.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Reducing the volume of blood sampled from neonatal or paediatric patients is crucial for research purposes, with skin prick and capillary microsamples producing comparable results to conventional arterial blood sampling in terms of meropenem concentrations. CMS samples have been found to be stable when stored in the capillary tube for certain durations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL AND BIOANALYTICAL CHEMISTRY</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/23280227/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27648373" class="text-dark hover-underline">Capillary electrophoresis as a simple and low-cost analytical tool for use in money-constrained situations</a> </h4> <p class="text-ellipsis-2">Ann Van Schepdael</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7855.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> The review demonstrates that capillary electrophoresis is a valuable tool for analysis in resource-limited environments. Its low-cost, high efficiency, and environmental friendliness make it ideal for such situations. The review summarizes recent research in this field, focusing on accessible CE hardware and simple instrumental procedures. It highlights applications relevant to low-resource settings, including pharmaceutical, environmental, and forensic analyses. Overall, significant progress has been made in improving analytical capacity worldwide, but more efforts are needed from researchers, local governments, and funding agencies. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">TRAC-TRENDS IN ANALYTICAL CHEMISTRY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27648373/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biology </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28928720" class="text-dark hover-underline">Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells</a> </h4> <p class="text-ellipsis-2">Jong Il Ahn, Liang Zhang, Harsha Ravishankar, Lixin Fan, Klara Kirsch, Yan Zeng, Lingjun Meng, Jung-Eun Park, Hye-Yeoung Yun, Rodolfo Ghirlando, Buyong Ma, David Ball, Bonsu Ku, Ruth Nussinov, Jeremy D. Schmit, William F. Heinz, Seung Jun Kim, Tatiana Karpova, Yun-Xing Wang, Kyung S. Lee</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10930.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Structural, biophysical, and imaging data demonstrate that self-assembly of the pericentrosomal proteins Cep63 and Cep152 is a stepwise and concentration-dependent process. Defects in this process disrupt proper centriole duplication mediated by Plk4. This study provides insights into the organization and function of pericentriolar materials (PCM) and offers a potential model for studying PCM-related diseases in other species. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">COMMUNICATIONS BIOLOGY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28928720/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/23434890" class="text-dark hover-underline">Stronger together: Analytical techniques for recombinant adeno associated virus</a> </h4> <p class="text-ellipsis-2">Andrei Hutanu, David Boelsterli, Claudio Schmidli, Cristina Montealegre, Mike H. N. Dang Thai, Balazs Bobaly, Marius Koch, Maria A. Schwarz</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2465.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> With FDA approval of rAAV-based gene therapies, efforts are being made to improve manufacturing and quality control processes. Various analytical methods are used to analyze the complex DNA composition inside rAAVs, showing that a combination of techniques is essential for a clear understanding of the virus interior. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ELECTROPHORESIS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/23434890/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Applied </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81912936" class="text-dark hover-underline">Advances in magnetic analytical extraction techniques for detecting antibiotic residues in edible samples</a> </h4> <p class="text-ellipsis-2">Asmaa Kamal El-Deen, Chaudhery Mustansar Hussain</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2892.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> The widespread use of antibiotics in agriculture and animal husbandry has led to the increase of antibiotic-resistant bacteria, so it is crucial to monitor and regulate the amount of antibiotics in food. Magnetic analytical extractions (MAE) have become a potential method for extracting antibiotic residues from food, and the emergence of new MNPs has improved its selectivity and sensitivity. This review paper discusses the current development, problems, and future development of MAE for extracting antibiotic residues from edible samples. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FOOD CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81912936/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Computer Science, Artificial Intelligence </span> </div> <h4> <a href="https://www.peeref.com/zh/works/85013467" class="text-dark hover-underline">A joint entity and relation extraction framework for handling negative samples problems in named entity recognition</a> </h4> <p class="text-ellipsis-2">Hongbin Zhang, Guangyu Lin, Kezhou Chen, Nankai Lin, Lianglun Cheng, Aimin Yang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/760.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> We propose a joint entity and relation extraction framework (JEREF) to address the data imbalance and hard negative sample problems in existing methods, aiming to better learn positive and negative samples in entity classification. The framework is evaluated on SciERC and ADE datasets, outperforming other state-of-the-art methods. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">APPLIED SOFT COMPUTING</span> (2025) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/85013467/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Inorganic & Nuclear </span> </div> <h4> <a href="https://www.peeref.com/zh/works/33748126" class="text-dark hover-underline">Applications of metal complexes in analytical chemistry: A review article</a> </h4> <p class="text-ellipsis-2">Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2055.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">COORDINATION CHEMISTRY REVIEWS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/33748126/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/25609157" class="text-dark hover-underline">Immunoassay-Compatible Inactivation of SARS-CoV-2 in Plasma Samples for Enhanced Handling Safety</a> </h4> <p class="text-ellipsis-2">Oi Wah Liew, Felic Fanusi, Jessica Yan Xia Ng, Bintou Ahmadou Ahidjo, Samantha Shi Min Ling, Shera Lilyanna, Jenny Pek Ching Chong, Angeline Eng Siew Lim, Wei Zheng Lim, Sindhu Ravindran, Justin Jang Hann Chu, Shir Lynn Lim, Arthur Mark Richards</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10704.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study evaluated the efficacy of different methods, including heat, detergents, and solvent-detergent combinations, for inactivating SARS-CoV-2 in plasma and their impact on immunoassays. The solvent-detergent treatment using 0.3% TNBP/1% Triton X-100 was found to be compatible with more than half of the immunoassays tested and effectively reduced the infectivity of SARS-CoV-2 in plasma. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ACS OMEGA</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/25609157/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Review </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28715384" class="text-dark hover-underline">Greenness assessment of analytical methods used for antibiotic residues determination in food samples</a> </h4> <p class="text-ellipsis-2">Christina Vakh, Marek Tobiszewski</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7855.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Food of animal origin is important for a healthy and sustainable diet, but residues of pharmaceuticals, particularly antibiotics, can cause health problems. Analytical methods used to detect contaminants in food need to be simple, selective, high throughput, and have low detection limits. Recently, greenness metric tools, such as AGREE, have been used to evaluate the environmental impact of analytical procedures. AGREE was used to assess the greenness of liquid and solid-phase extraction procedures for detecting antibiotic residues in food samples. The procedures were compared based on twelve input variables, and the total score indicated the overall impact on greenness improvement. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">TRAC-TRENDS IN ANALYTICAL CHEMISTRY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28715384/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> <div id="articles_from_authors" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biochemical Research Methods </span> </div> <h4> <a href="https://www.peeref.com/zh/works/85006815" class="text-dark hover-underline">Long-Term Protein Synthesis with PURE in a Mesoscale Dialysis System</a> </h4> <p class="text-ellipsis-2">Laura Roset Julia, Laura Grasemann, Francesco Stellacci, Sebastian J. Maerkl</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study utilized an easy-to-assemble, medium-scale dialysis system to address the limited reaction lifespan and yield of the PURE cell-free system. By periodically exchanging the feeding solution, a protein yield of 1.16mg/mL GFP was achieved, and protein synthesis was prolonged for at least 12.5 consecutive days, demonstrating the stability of the system. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ACS SYNTHETIC BIOLOGY</span> (2025) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/85006815/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83029524" class="text-dark hover-underline">Amino Acids and Their Biological Derivatives Modulate Protein-Protein Interactions in an Additive Way</a> </h4> <p class="text-ellipsis-2">Xufeng Xu, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study shows that PPI measured in test tubes and cells differ due to the complexity of the intracellular environment. AAs and their derivatives can make protein dispersions more stable, and different AA derivatives, AA mixtures, and short peptides can all effectively modulate PPI, with additive effects. This study provides insights for designing biocompatible molecules to stabilize protein interactions. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF PHYSICAL CHEMISTRY LETTERS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83029524/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83407020" class="text-dark hover-underline">Nature-inspired recycling of a protein mixture into a green fluorescent protein-based hydrogel</a> </h4> <p class="text-ellipsis-2">Laura Roset Julia, Sebastian J. Maerkl, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Protein-based materials have various remarkable properties and are widely used. In nature, proteins can be recycled in multiple ways, and protein metabolism is a great example. In this process, a random mixture of proteins is digested into amino acids, which can then be used by cells to synthesize the needed proteins. Recently, researchers have demonstrated that the protein recycling process can be performed in vitro and named it NaCRe. In previous experiments, they could only produce a small amount of recycled protein in the microgram scale from various protein mixtures. Here, they show that NaCRe can convert a milligram protein mixture containing silk into a milligram of green fluorescent protein hydrogel. They also indicate that for NaCRe to be effective, the starting protein mixture must contain a good balance of all AAs, and discuss the challenges encountered when scaling up NaCRe. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">RSC SUSTAINABILITY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83407020/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Physical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83417312" class="text-dark hover-underline">Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations</a> </h4> <p class="text-ellipsis-2">Pamina M. Winkler, Cecilia Siri, Johann Buczkowski, Juliana V. C. Silva, Lionel Bovetto, Christophe Schmitt, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study quantified weak protein-protein interactions in solution using cross-interaction chromatography (CIC) and surface plasmon resonance (SPR), and demonstrated that they can be modulated by adding millimolar concentrations of free amino acids. The second osmotic virial cross-interaction coefficient (B-23) was determined as a proxy for the interaction strength between two different proteins using CIC, and the binding affinity between the same proteins was established using SPR. The results showed that amino acids proline, glutamine, and arginine can make the protein cross-interactions more repulsive or equivalently less attractive, and this modulation does not alter the protein's secondary structure. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">JOURNAL OF PHYSICAL CHEMISTRY B</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83417312/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Multidisciplinary Sciences </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84538552" class="text-dark hover-underline">Amino acids modulate liquid-liquid phase separation in vitro and in vivo by regulating protein-protein interactions</a> </h4> <p class="text-ellipsis-2">Xufeng Xu, Aleksander A. Rebane, Laura Roset Julia, Kathryn A. Rosowski, Eric R. Dufresne, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Liquid-liquid phase separation (LLPS) is an important intracellular process, and amino acids (AAs) play a key role in it. This study found that certain AAs can inhibit LLPS in vitro and also significantly suppress the formation of stress granules (SGs) in vivo, regardless of the stress type. Further studies showed that the presence of AAs not only slows down the formation of SGs, but also reduces their saturation number and prevents their coalescence. Finally, through sedimentation-diffusion equilibrium analytical ultracentrifuge (SE-AUC) studies, it was found that the inhibitory effect of AAs on LLPS may be due to their modulation of protein-protein and RNA-RNA interactions. This study reveals the important role of cellular AAs in LLPS and provides new ideas for the treatment of SG-related diseases. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84538552/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27725522" class="text-dark hover-underline">Recycling of Polymerase Chain Reaction (PCR) Kits</a> </h4> <p class="text-ellipsis-2">Weina Liu, Yong Zhu, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Researchers demonstrated a recyclable PCR kit to reduce dependence on nucleic acid resources and address the shortage of PCR kits during the pandemic. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ACS SUSTAINABLE CHEMISTRY & ENGINEERING</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27725522/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27800711" class="text-dark hover-underline">Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles</a> </h4> <p class="text-ellipsis-2">Suiyang Liao, Lixia Wei, Arthur Eliot Bouchez, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Most studied parameters of nanoparticles' interactions with cells are currently static, while proteins have dynamic structures. This study focuses on single-chain polymeric nanoparticles (SCPNs) that undergo dynamic changes. By creating multiple sets of particles with identical polymer chains, it was found that cell uptake discriminates between dynamic and static SCPN isomers. Dynamic isomers are uptaken more through different endocytic pathways, while static isomers access the cytosol more efficiently. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">CHEM</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27800711/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Pharmacology & Pharmacy </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27812168" class="text-dark hover-underline">Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin</a> </h4> <p class="text-ellipsis-2">Yong Zhu, Andrey A. A. Sysoev, Paulo H. Jacob Silva, Marine Batista, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> We have reported that CD-6'SLN irreversibly deactivates virions and improves mice survival in H1N1 infection model. CD-6'SLN interacts with the viral envelope protein HA, but not with NA, inhibiting influenza virus through an extracellular mechanism. Our findings suggest that combining viral protein-specific epitopes with hydrophobic linkers provides a strategy for developing antiviral drugs. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">PHARMACEUTICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27812168/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27634467" class="text-dark hover-underline">Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery</a> </h4> <p class="text-ellipsis-2">Ester Canepa, Davide Bochicchio, Giorgia Brosio, Paulo Henrique Jacob Silva, Francesco Stellacci, Silvia Dante, Giulia Rossi, Annalisa Relini</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Membrane fusion is essential for eukaryotic cell functionality and is regulated by specialized proteins, lipid composition, and ion environment. Liposomes decorated with amphiphilic Au nanoparticles (AuLips) have been shown to act as tunable fusion machinery, triggered by divalent ions and tunable by liposome cholesterol content. This research provides new mechanistic details on the fusogenic activity of AuNPs and demonstrates their potential as artificial fusogenic agents for biomedical applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SMALL</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27634467/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Materials Science, Biomaterials </span> </div> <h4> <a href="https://www.peeref.com/zh/works/34582159" class="text-dark hover-underline">Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots</a> </h4> <p class="text-ellipsis-2">Ilsong Lee, Jieun Moon, Hoomin Lee, Sungjun Koh, Gui-Min Kim, Laure Gauthe, Francesco Stellacci, Yun Suk Huh, Pilhan Kim, Doh C. Lee</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study uses indium phosphide (InP) quantum dots (QDs) for photodynamic therapy (PDT) to treat infections caused by multidrug-resistant (MDR) bacteria, demonstrating superior bactericidal efficiency compared to common antibiotics. InP QDs generate superoxide during PDT, enabling efficient and selective killing of MDR bacteria while remaining non-toxic to mammalian cells. In in vivo studies, InP QDs showed excellent therapeutic and prophylactic efficacy in treating MDR bacterial infections. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOMATERIALS SCIENCE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/34582159/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/34687137" class="text-dark hover-underline">Monovalent ion-mediated charge-charge interactions drive aggregation of surface-functionalized gold nanoparticles</a> </h4> <p class="text-ellipsis-2">Emanuele Petretto, Quy K. Ong, Francesca Olgiati, Ting Mao, Pablo Campomanes, Francesco Stellacci, Stefano Vanni</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Monolayer-protected metal nanoparticles have potential applications in industry and biology, and can be used to study the behavior of matter at nanoscopic scales. This study reveals that electrostatic interactions can lead to the formation of NP dimers at physiological ion concentrations. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANOSCALE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/34687137/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/34808806" class="text-dark hover-underline">Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes</a> </h4> <p class="text-ellipsis-2">Enrico Lavagna, Davide Bochicchio, Anna L. De Marco, Zekiye P. Guven, Francesco Stellacci, Giulia Rossi</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study demonstrates that functionalized gold nanoparticles can spontaneously aggregate in zwitterionic lipid bilayers. The driving forces for aggregation include ion-mediated charge-charge interactions, lipid depletion, and membrane curvature. These forces originate from the configurational flexibility of the nanoparticle shell. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANOSCALE</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/34808806/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/23255033" class="text-dark hover-underline">In-situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA</a> </h4> <p class="text-ellipsis-2">Neda Iranpour Anaraki, Marianne Liebi, Quy Ong, Clement Blanchet, Anjani K. Maurya, Francesco Stellacci, Stefan Salentinig, Peter Wick, Antonia Neels</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study investigates the influence of nanoparticles properties on colloidal stability in NaCl and protein solutions, revealing that PEG coating provides high stability for nanoparticles. Different mechanisms are observed for citrate-capped nanoparticles, with proteins attaching to the nanoparticle surfaces. Findings pave the way for designing and synthesizing nanoparticles with controlled behaviors in biomedical applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED FUNCTIONAL MATERIALS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/23255033/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/23255518" class="text-dark hover-underline">DNA as a Recyclable Natural Polymer</a> </h4> <p class="text-ellipsis-2">Weina Liu, Simone Giaveri, Daniel Ortiz, Francesco Stellacci</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Nature has the ability to recycle its components for self-sustenance, such as the digestion of proteins into amino acids by living organisms and subsequent synthesis of new proteins. Recent research has shown that protein recycling can also be achieved outside living organisms. This study demonstrates the production of dNTPs from calf DNA through enzymatic phosphorylation, which can be further utilized for PCR and DNA diagnosis. This approach provides an efficient, convenient, and environmentally friendly method for producing dNTPs and DNA in accordance with the circular economy paradigm. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ADVANCED FUNCTIONAL MATERIALS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/23255518/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> <div id="articles_from_journal" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83077947" class="text-dark hover-underline">Ultrasensitive and Wash-Free Detection of Tumor Extracellular Vesicles by Aptamer-Proximity-Ligation-Activated Rolling Circle Amplification Coupled to Single Particle ICP-MS</a> </h4> <p class="text-ellipsis-2">Xue-Wei Zhang, Gong-Xiang Qi, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed an aptamer-proximity-ligation-activated rolling circle amplification (RCA) method for EV membrane recognition, combined with single particle inductively coupled plasma mass spectrometry (sp-ICP-MS) for the quantification of TEVs. The method has excellent sensitivity and selectivity, can detect TEVs in a wash-free manner, and has high accuracy in distinguishing cancer patients from healthy donors. The method is simple and fast to operate, and has great potential in the applications of life sciences and personalized medicine. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83077947/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83065451" class="text-dark hover-underline">CRISPR/Cas12a-Responsive Smart DNA Hydrogel for Sensitive Electrochemiluminescence Detection of the Huanglongbing Outer Membrane Protein Gene</a> </h4> <p class="text-ellipsis-2">Yutian Zhang, Can Hu, Yashi Yin, Kejing Ren, Yingsi He, Yanru Gao, Heyou Han, Chengzhou Zhu, Wenjing Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel ECL biosensor was reported for the highly sensitive detection of the Omp gene of CLas, which causes citrus Huanglongbing. The biosensor combines RCA with a CRISPR/Cas12a-responsive smart DNA hydrogel. The performance of the biosensor was evaluated with live citrus leaf samples, and the results were in excellent agreement with the qPCR results. The sensing strategy expands the versatility of ECL for detecting different levels of DNA in plants. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83065451/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83027949" class="text-dark hover-underline">Multi-Enzyme Cascade Nanoreactors for High-Throughput Immunoassay: Transitioning Concept in Lab to Application in Community</a> </h4> <p class="text-ellipsis-2">Zhichao Yu, Juan Tang, Man Xu, Di Wu, Yuan Gao, Yongyi Zeng, Xiaolong Liu, Dianping Tang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> In this study, a platinum nanozyme loaded with cholesterol oxidase was constructed and applied to the construction of a nanozyme-enzyme-linked immunosorbent assay model, enabling high-throughput and rapid evaluation of cancer markers. The nanozyme platform exhibited efficient enzyme-like catalytic efficiency and photothermal conversion efficiency, and could be used for the development of multi-enzyme photothermal probes. Systemic temperature evaluations were performed using a handheld microelectromechanical system thermal imager to determine the cancer antigen 15-3 profile in the samples. This study provides a new idea for the development of efficient multi-enzyme portable colorimetric-photothermal platforms, which is helpful for promoting the community-based process of early cancer detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83027949/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83570573" class="text-dark hover-underline">Structure Remodeling Strategy for Open-Cage NiFe@Fe-bis-PBA with Enhanced Peroxidase-like Activity To Monitor Tumor Markers</a> </h4> <p class="text-ellipsis-2">Ruixin Liu, Feng Shi, Haibing Zhu, Kai Liu, Zijun Lai, Yaoyao Li, Zhanjun Yang, Juan Li</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study presents a structural remodeling strategy for the construction of open-cage Fe PBA-anchored NiFePBA nanozymes with significantly enhanced enzyme-mimicking activity. Through detailed studies of their formation processes and mechanisms, it was found that the resulting nanozymes have a special open-cage core-shell structure. These nanozymes can be further used to immobilize secondary antibodies and construct highly sensitive electrochemical immunosensors for monitoring tumor markers. The sensor has a wide linear range and low detection limit, as well as high specificity, acceptable reproducibility, and stability. This work provides a general and promising strategy for remodeling PBA nanozymes, enhancing their enzyme-mimicking properties for applications in different fields. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83570573/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83031084" class="text-dark hover-underline">A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities</a> </h4> <p class="text-ellipsis-2">Kailing Li, Jun Wang, Jieqiong Wang, Zhi Zheng, Xinping Liu, Jikai Wang, Chenjing Zhang, Suisui He, Hua Wei, Cui-Yun Yu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study reports a smartphone-assisted programmable microfluidic paper-based analytical device that can simultaneously, accurately, and visually quantitative detect alkaline phosphatase and butyrylcholinesterase. The device utilizes colorimetric and photothermal signals and is based on a two-step bioenzyme-nanzyme cascade reaction, with low detection limits and excellent processability. Through the analysis of clinical serum samples, the practicability and efficiency of the platform have been demonstrated. The platform has great potential in simultaneously detecting multiple enzyme activities in real samples. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83031084/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84045655" class="text-dark hover-underline">Machine Learning-Based Nanozyme Sensor Array as an Electronic Tongue for the Discrimination of Endogenous Phenolic Compounds in Food</a> </h4> <p class="text-ellipsis-2">Wenjie Jing, Yajun Yang, Qihao Shi, Yu Wang, Fufeng Liu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel bifunctional vanillic acid-Cu nanozyme with peroxidase-like and laccase-like activities was successfully fabricated. Based on the nanozyme, a six-channel nanozyme sensor array was constructed for discriminant analysis of nine EPs. Combined with ANN algorithms, accurate identification and prediction of EPs in real samples were achieved. Finally, a portable detection method based on a smartphone was proposed. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84045655/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83088898" class="text-dark hover-underline">Highly Specific Aptamer-Antibody Birecognized Sandwich Module for Ultrasensitive Detection of a Low Molecular Weight Compound</a> </h4> <p class="text-ellipsis-2">Ying Zhou, Yuying Wei, Jia Zhang, Xiaoyu Shi, Liang Ma, Ruo Yuan</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study introduces the aptamer-antibody sandwich module for the first time to accurately recognize low molecular weight compounds. Compared with the traditional dual-antibody module, the sandwich module has high recognition efficiency and can reduce false positives and false negatives. Based on this, a sensitive electrochemiluminescence biosensor was constructed for the detection of mycotoxin zearalenone. The sensor has a low detection limit and high sensitivity, and has great application potential in food analysis, environmental monitoring, and clinical diagnosis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83088898/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83121104" class="text-dark hover-underline">Steric Hindrance-Mediated Enzymatic Reaction Enable Homogeneous Dual Fluorescence Indicators Aptasensing of Hepatocellular Carcinoma CTCs</a> </h4> <p class="text-ellipsis-2">Pengjun Jiang, Zixuan Zhan, Yufu Peng, Chengyong Wu, Yue Wang, Longfei Wu, Shiya Shi, Binwu Ying, Yonggang Wei, Piaopiao Chen, Jie Chen</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study describes a dual fluorescence indicator aptasensing strategy for CTCs in HCC, which eliminates the steric hindrance to affect the efficiency of the enzymatic reaction for quantitative analysis of CTCs. The system shows high sensitivity and specificity in the analysis of clinical samples, which is helpful for the early diagnosis of tumors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83121104/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83123857" class="text-dark hover-underline">Label-Free and DNAzyme-Mediated Biosensor with a High Signal-to-Noise Ratio for a Lumpy Skin Disease Virus Assay</a> </h4> <p class="text-ellipsis-2">Gaihua Cao, Nannan Yang, Jun Yang, Jiali Li, Lin Wang, Fuping Nie, Danqun Huo, Changjun Hou</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper introduces a novel label-free fluorescence method for the detection of lumpy skin disease virus (LSDV). Based on a light-up RNA aptamer, the method integrates recombinase polymerase amplification (RPA), CRISPR/Cas12a, 10-23 DNAzyme, and Baby Spinach RNA aptamer for triple cascade signal amplification. The method has ultrahigh sensitivity and specificity, with a practical detection limit of 1.29 copies μL-1 and 100 times higher sensitivity than RPA with Cas12a. In addition, the method has no cross-reactivity with other viruses and shows 100% accuracy in actual samples. Therefore, the method provides a new solution for the detection and prevention and control of LSDV. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83123857/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83067181" class="text-dark hover-underline">Nanoconfined Silver Nanoclusters Combined with X-Shaped DNA Recognizer-Triggered Cascade Amplification for Electrochemiluminescence Detection of APE1</a> </h4> <p class="text-ellipsis-2">Qiao-Lin Chen, Xue-Mei Zhou, Mei-Ling Zhao, Ya-Qin Chai, Ruo Yuan, Xia Zhong, Ying Zhuo</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A biosensor for APE1 activity detection was constructed based on nanoconfined ECL silver nanoclusters and X-shaped DNA recognizer-triggered cascade amplification. The sensor showed high sensitivity and stability, and could be used for biomarker detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83067181/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84294609" class="text-dark hover-underline">Highly Sensitive One-Pot Isothermal Assay Combining Rolling Circle Amplification and CRISPR/Cas12a for Aflatoxin B1 Detection</a> </h4> <p class="text-ellipsis-2">Xinxin Zhao, Zhongxing Wang, Hao Zhang, Jinpeng Liu, Wenli Wu, Li Yu, Chuanlai Xu, Xiao Wang, Qiongzheng Hu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel one-pot isothermal assay integrating RCA and CRISPR/Cas12a is reported for the detection of AFB1. The assay is ultrasensitive and can be visualized, and has been successfully applied to real samples with satisfactory recoveries. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84294609/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84384829" class="text-dark hover-underline">Near-Infrared Unimolecular Chemiluminescence Probes for Deep-Tissue Imaging</a> </h4> <p class="text-ellipsis-2">Ling Li, Xinyi Zhang, Yuxin Ren, Meiqi Li, Benkai Bao, Junqing Wang, Mengpan Zhang, Yanli Tang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Chemiluminescence imaging has minimal background autofluorescence and no excitation, making it a promising optical imaging technique. However, the emission of most chemiluminescent probes is concentrated in the visible light region, limiting tissue penetration. Although some NIR chemiluminescent probes have been reported based on the CRET strategy, energy loss is inevitable. Therefore, it is crucial to develop NIR unimolecular probes with direct chemiluminescence. This study proposes a strategy of increasing conjugation for designing and synthesizing novel NIR chemiluminescence unimolecular probes, and investigates their direct CL mechanism. Compared with CRET-based chemiluminescence, this direct CL avoids energy loss and is more conducive to converting chemical energy into chemiluminescence. The study also prepares corresponding nanoparticles and successfully applies them to in vivo chemiluminescence imaging of various inflammation models. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84384829/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83146594" class="text-dark hover-underline">Bioreaction-Compatible Bivariate Lanthanide MOF Sensor Enables Stimulus-Multiresponsive Platform for ctDNA On-Site Detection</a> </h4> <p class="text-ellipsis-2">Yumin Feng, Long Yu, Qi Xu, Zhongyu Wei, Zhiwen Gan, Xilin Nie, Yuxiu Xiao</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper presents a novel circulating tumor DNA (ctDNA) detection platform in liquid biopsy based on a newly designed bivariable lanthanide metal-organic framework (Ln-MOF). The platform detects ctDNA by quantifying the by-product pyrophosphate (PPi) of DNA amplification and combines with the isothermal nucleic acid exponential amplification reaction (EXPAR), achieving the advantages of low cost, convenience, sensitivity, and suitability for on-site detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83146594/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84093256" class="text-dark hover-underline">CRISPR-Responsive RCA-Based DNA Hydrogel Biosensing Platform with Customizable Signal Output for Rapid and Sensitive Nucleic Acid Detection</a> </h4> <p class="text-ellipsis-2">Yan Zhang, Weiwei Wang, Xinxi Zhou, Haonan Lin, Xiaotong Zhu, Yongliang Lou, Laibao Zheng</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper presents a novel biosensing platform that integrates the CRISPR/Cas12a system into an RCA-based DNA hydrogel, addressing the challenges faced by current nucleic acid-responsive DNA hydrogels in biosensing applications. The platform demonstrates high specificity and sensitivity, enabling rapid and accurate detection of the mecA gene in clinical samples, and holds great promise for future applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84093256/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83012837" class="text-dark hover-underline">Enhancing Kinase Activity Detection with a Programmable Lanthanide Metal-Organic Framework via ATP-to-ADP Conversion</a> </h4> <p class="text-ellipsis-2">Long Yu, Yongjin Shen, Qi Xu, Zhiwen Gan, Yumin Feng, Chunxu Yang, Yuxiu Xiao</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study investigated the interaction between Ln-MOF and phosphate analytes and its application in biosensing. By synthesizing six Eu-MOFs and selecting Eu-TPTC as a fluorescent probe, high-precision detection of creatine kinase activity was achieved. This research provides a new idea for kinase activity assays and demonstrates the application potential of Ln-MOF in analytical chemistry. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83012837/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="modal fade" id="export-citation" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>×</span></button> <h4 class="modal-title">导出引文 <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-3 px-4 f16"> <form action="https://www.peeref.com/zh/works/citation/download" method="GET" target="_blank"> <div class="radio"> <label> <input type="radio" name="fileType" value="PlainText" checked> <strong>纯文本</strong> </label> </div> <div class="radio"> <label> <input type="radio" name="fileType" value="RIS"> <strong>RIS</strong> <span>- 导出格式兼容大多数主要的参考管理软件，如Endnote和Zotero</span> </label> </div> <div class="radio"> <label> <input type="radio" name="fileType" value="BibTeX"> <strong>BibTeX</strong> <span>- 导出格式兼容LaTeX</span> </label> </div> <input type="hidden" name="articleId" value="82557507"> <div class="mt-lg-4 text-center"> <button class="citation-download-btn btn btn-primary"> 导出 </button> </div> </form> </div> </div> </div> </div> </div> <div class="modal fade" id="share-paper" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>×</span></button> <h4 class="modal-title">分享论文 <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-4"> <div class="social-share"> <a class="social-share-item email" href="mailto:?subject=Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation&body=https://www.peeref.com/zh/works/82557507" target="_blank"> <img src="https://peeref-open.s3.amazonaws.com/images/social-share-email.svg" height="16"> </a> <a class="social-share-item linkedin" href="https://www.linkedin.com/shareArticle/?url=https://www.peeref.com/zh/works/82557507" target="_blank"> <img src="https://peeref-open.s3.amazonaws.com/images/social-share-linkedin.svg" height="16"> </a> <a class="social-share-item twitter" href="https://twitter.com/share?url=https://www.peeref.com/zh/works/82557507" target="_blank"> <img src="https://peeref-open.s3.amazonaws.com/images/social-share-twitter.svg" height="16"> </a> <a class="social-share-item wechat" href="javascipt:;" onclick="window.open('https://api.qrserver.com/v1/create-qr-code/?size=154x154&data=https://www.peeref.com/zh/works/82557507', 'newwindow', 'height=300, width=300')"> <img src="https://peeref-open.s3.amazonaws.com/images/social-share-wechat.svg" height="16"> </a> <a class="social-share-item facebook" href="https://www.facebook.com/sharer/sharer.php?u=https://www.peeref.com/zh/works/82557507" target="_blank"> <img src="https://peeref-open.s3.amazonaws.com/images/social-share-facebook.svg" height="16"> </a> </div> </div> </div> </div> </div> </div> <back-top-button></back-top-button> </main> <div class="container"> <div class="footer"> <div class="col-md-10"> <div class="d-flex flex-wrap" style="font-size: 15px;"> <a href="https://www.peeref.com/zh/works" class="mx-3 px-2"> 论文 </a> <a href="https://www.peeref.com/zh/posters" class="mx-3 px-2"> 海报 </a> <a href="https://www.peeref.com/zh/abstracts" class="mx-3 px-2"> 摘要 </a> <a href="https://www.peeref.com/zh/webinars" class="mx-3 px-2"> 研讨会 </a> <a href="https://www.peeref.com/zh/questions" class="mx-3 px-2"> 问题 </a> <a href="https://www.peeref.com/zh/hubs" class="mx-3 px-2"> 讨论圈 </a> <a href="https://www.peeref.com/zh/funding" class="mx-3 px-2"> 基金 </a> <a href="https://www.peeref.com/zh/journals" class="mx-3 px-2"> 期刊 </a> <a href="https://www.peeref.com/zh/connect" class="mx-3 px-2"> 科研社交 </a> <a href="https://www.peeref.com/zh/e-collections" class="mx-3 px-2"> 资讯集成 </a> <a href="https://www.peeref.com/zh/reviewer" class="mx-3 px-2"> 审稿人 </a> <a href="https://www.peeref.com/zh/about" class="mx-3 px-2"> 关于我们 </a> <a href="https://www.peeref.com/zh/about/faq" class="mx-3 px-2"> 常见问题 </a> <a href="https://www.peeref.com/zh/mobile-app" class="mx-3 px-2"> 移动App </a> <a href="https://www.peeref.com/zh/about/privacy" class="mx-3 px-2"> 隐私条款 </a> <a href="https://www.peeref.com/zh/about/terms-of-use" class="mx-3 px-2"> 使用条款 </a> </div> </div> <div class="col-md-2"> <div class="d-flex justify-content-end"> <div class="sns"> <a href="https://www.facebook.com/Peeref-113216326987528" target="_blank"> <i class="ivu-icon ivu-icon-logo-facebook"></i> </a> <a href="https://twitter.com/Peeref1" target="_blank"> <i class="ivu-icon ivu-icon-logo-twitter"></i> </a> </div> </div> </div> </div> <div class="copyright"> © Peeref 2019-2025. All rights reserved. </div> </div> </div> <script src="https://peeref-open.s3.amazonaws.com/js/manifest.42bb1b6291289ba30c76.js"></script> <script src="https://peeref-open.s3.amazonaws.com/js/vendor.362294362b899c82d030.js"></script> <script src="https://peeref-open.s3.amazonaws.com/js/app.ee6e6ad3c472f6e3f93d.js"></script> <script> $(function() { $('#reading-btn').click(function() { const navHeight = $("#article-sticky-navbar").height(); const readingAreaTop = $("#collection").offset().top; const readingAreaHeight = readingAreaTop - navHeight - 30; $("html, body").animate( { scrollTop: readingAreaHeight }, 400 ); return false; }) }); </script> <script src="https://peeref-open.s3.amazonaws.com/vendor/MathJax-274/MathJax.js?config=default" async></script> <script async src="https://www.googletagmanager.com/gtag/js?id=UA-152048790-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'UA-152048790-1'); </script> <script type="text/javascript" id="cookiebanner" src="https://peeref-open.s3.amazonaws.com/js/cookiebanner.min.js" data-position="bottom" data-cookie="_uc_" data-expires="Wed, 31 Dec 2025 00:00:00 GMT" data-font-size="15px" data-close-text="接受" data-close-precedes="false" data-close-style="border-radius: 5px; margin: 3px 15px; padding: 3px 10px; display: inline-block; font-weight: bold; background: rgb(245, 207, 71); color: rgb(16, 75, 125);" data-linkmsg="" data-moreinfo-decoration="underline" data-moreinfo="https://www.peeref.com/zh/about/privacy" data-bg="rgb(16, 75, 125)" data-link="rgb(255, 255, 255)" data-message="Peeref 使用 cookies 改善你的使用体验。请阅读 <a>隐私条款</a> 获取更多信息。"> </script> </body> </html>

CINXE.COM

Versatile Capillary Cells for Handling Concentrated Samples in Analytical Ultracentrifugation - Peeref