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Nanoconfined Silver Nanoclusters Combined with X-Shaped DNA Recognizer-Triggered Cascade Amplification for Electrochemiluminescence Detection of APE1 - Peeref

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rel="alternate" hreflang="en" href="https://www.peeref.com/works/83067181" > <span>English</span> </a> <a rel="alternate" hreflang="zh" href="https://www.peeref.com/zh/works/83067181" > <span>中文</span> </a> </div> </li> </ul> </ul> </div> </nav> <main> <div id="top-info-banner" class="container-fluid mb-0"> <div class="container"> <div class="d-flex align-items-center" style="margin-top: 30px;"> <span class="text-white"> <strong class="f18">☆</strong> <span class="f16">4.8</span> </span> <span class="mx-3"></span> <span class="tag">Article</span> </div> <h1 class="title title-for-article"> Nanoconfined Silver Nanoclusters Combined with X-Shaped DNA Recognizer-Triggered Cascade Amplification for Electrochemiluminescence Detection of APE1 </h1> <div class="help-links-left"> <p class="pub-info"> ANALYTICAL CHEMISTRY (2024) </p> </div> </div> </div> <div id="article-sticky-navbar"> <div class="container"> <div class="d-flex justify-content-between flex-wrap flex-md-nowrap"> <div 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href="https://www.peeref.com/zh/journals/518/analytical-chemistry"> ANALYTICAL CHEMISTRY </a> </h5> <span> 卷 96, 期 28, 页码 11383-11389 </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">出版社</h4> <div class="f16"> <h5 class="title f16 text-primary"> AMER CHEMICAL SOC </h5> <div class="my-2"> DOI: 10.1021/acs.analchem.4c01438 </div> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">关键词</h4> <div class="f16"> - </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">类别</h4> <div class="f16"> <span class="d-block"> <a href="https://www.peeref.com/zh/works/list?category=Chemistry%2C+Analytical" target="_blank" class="text-dark btn btn-link p-0 text-left"> Chemistry, Analytical </a> </span> </div> </div> <div class="mb-3 pb-3"> <h4 class="mt-0">资金</h4> <div class="f16"> <ol class=""> <li>NNSF of China [22376170, 22374123]</li> <li>Fundamental Reaeacher Funds for the Central Universities, China [SWU-XJLJ202303]</li> </ol> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 text-center">向作者/读者索取更多资源</h4> <div class="requests"> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/file.png" alt=""> </div> <h4>Protocol</h4> <p> <a href="https://www.peeref.com/zh/works/83067181/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> <div class="requests-item"> <div class="icon"> <img src="https://peeref-open.s3.amazonaws.com/images/experiment.png" alt=""> </div> <h4>Reagent</h4> <p> <a href="https://www.peeref.com/zh/works/83067181/resource" class="btn btn-outline-primary btn-sm"> 社区支持 </a> </p> </div> </div> </div> </div> <div class="col-md-8 px-0 pl-md-3"> <div id="article-summary-panel" class="mb-4"> <ul class="nav nav-tabs" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#ai_summary" data-toggle="tab" class="summary-tab mx-0 f16 text-dark"> <strong>智能总结</strong> <strong class="text-danger ml-1"><i>New</i></strong> </a> </li> <li class=""> <a href="#raw_abstract" data-toggle="tab" class="abstract-tab mx-0 f16 text-dark"> <strong>摘要</strong> </a> </li> </ul> <div class="tab-content border border-top-0"> <div id="ai_summary" class="tab-pane active"> <div class="summary-panel panel-box mb-0 rounded shadow-none"> <div class="f16">A biosensor for APE1 activity detection was constructed based on nanoconfined ECL silver nanoclusters and X-shaped DNA recognizer-triggered cascade amplification. The sensor showed high sensitivity and stability, and could be used for biomarker detection.</div> </div> </div> <div id="raw_abstract" class="tab-pane "> <div class="abstract-panel panel-box mb-0 rounded shadow-none"> <div class="f16">Apurinic/apyrimidinic endonuclease 1 (APE1), as a vital base excision repair enzyme, is essential for maintaining genomic integrity and stability, and its abnormal expression is closely associated with malignant tumors. Herein, we constructed an electrochemiluminescence (ECL) biosensor for detecting APE1 activity by combining nanoconfined ECL silver nanoclusters (Ag NCs) with X-shaped DNA recognizer-triggered cascade amplification. Specifically, the Ag NCs were prepared and confined in the glutaraldehyde-cross-linked chitosan hydrogel network using the one-pot method, resulting in a strong ECL response and exceptional stability in comparison with discrete Ag NCs. Furthermore, the self-assembled X-shaped DNA recognizers were designed for APE1 detection, which not only improved reaction kinetics due to the ordered arrangement of recognition sites but also achieved high sensitivity by utilizing the recognizer-triggered cascade amplification of strand displacement amplification (SDA) and DNAzyme catalysis. As expected, this biosensor achieved sensitive ECL detection of APE1 in the range of 1.0 x 10(-3) Umu L-1 to 1.0 x 10(-10) Umu L-1 with the detection limit of 2.21 x 10(-11) Umu L-1, rendering it a desirable approach for biomarker detection.</div> </div> </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">作者</h4> <div class="mb-3"> <article-authors tid="83067181" list="[{&quot;name&quot;:&quot;Qiao-Lin Chen&quot;,&quot;sequence&quot;:1},{&quot;name&quot;:&quot;Xue-Mei Zhou&quot;,&quot;sequence&quot;:2},{&quot;name&quot;:&quot;Mei-Ling Zhao&quot;,&quot;sequence&quot;:3},{&quot;name&quot;:&quot;Ya-Qin Chai&quot;,&quot;sequence&quot;:4},{&quot;name&quot;:&quot;Ruo Yuan&quot;,&quot;sequence&quot;:5},{&quot;name&quot;:&quot;Xia Zhong&quot;,&quot;sequence&quot;:6},{&quot;name&quot;:&quot;Ying Zhuo&quot;,&quot;sequence&quot;:7}]" verified="[]" page="work" ></article-authors> </div> <div class="alert alert-warning mb-0"> <h5 class="mt-0 bg-warning text-dark px-3 rounded d-inline-block"> 我是这篇论文的作者 </h5> <div class="font-weight-bold f13"> 点击您的名字以认领此论文并将其添加到您的个人资料中。 </div> </div> </div> <div class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">评论</h4> <div class="d-flex flex-wrap flex-md-nowrap"> <div class="flex-grow-1"> <h4 class="f16"> 主要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="主要评分表示论文的整体质量水平。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap align-items-center alert mb-0"> <div class="d-flex align-items-center justify-content-center"> <Rate disabled allow-half value="4.8" style="font-size: 28px;"></Rate> <strong class="f20 m-3" style="color: #f5a623;">4.8</strong> </div> <div class="text-muted mx-4"> 评分不足 </div> </div> <h4 class="f16"> 次要评分 <a href="javascript:;" data-toggle="tooltip" data-placement="right" title="次要评分独立反映论文的优点或缺点。"> <i class="ivu-icon ivu-icon-md-help-circle f18 ml-2"></i> </a> </h4> <div class="d-flex flex-wrap flex-md-nowrap alert"> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">新颖性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">重要性</h5> <strong class="mx-4">-</strong> </div> <div class="d-flex flex-shrink-0 align-items-center mr-3"> <h5 class="my-0">科学严谨性</h5> <strong class="mx-4">-</strong> </div> </div> </div> <div class="flex-shrink-0"> <div class="border bg-light py-2 px-4"> <h5 class="mb-1">评价这篇论文</h5> <Rate class="f24" @on-change="function(value){ location.href='https://www.peeref.com/zh/works/83067181/comments?rating='+value }"></Rate> </div> </div> </div> </div> <div id="collection" class="f15 panel-box rounded shadow-none border"> <h4 class="mt-0 heading-count">推荐</h4> <div class="my-3"> <ul class="nav nav-pills border-bottom pb-3" style="list-style: none; padding-left: 0;"> <li class="active"> <a href="#articles_from_related" data-toggle="tab" class="mx-0 f15"> <strong>相关</strong> </a> </li> <li class=""> <a href="#articles_from_authors" data-toggle="tab" class="mx-0 f15"> <strong>来自同一作者</strong> </a> </li> <li class=""> <a href="#articles_from_journal" data-toggle="tab" class="mx-0 f15"> <strong>来自同一期刊</strong> </a> </li> </ul> <div class="tab-content"> <div id="articles_from_related" class="tab-pane active"> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82881682" class="text-dark hover-underline">Simplified rolling circle amplification driven in situ generation of electrochemiluminescent silver nanoclusters for APE1 activity monitoring</a> </h4> <p class="text-ellipsis-2">Lin-Ru Hong, Wen Li, Ming-Yue Lu, Hao Xu, Wei Liu, Yun Zhu, Ying Zhuo</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7475.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed a strategy based on simplified rolling circle amplification (RCA) for in situ generation of electrochemiluminescent (ECL) silver nanoclusters (Ag NCs) to monitor the activity of apurinic/apyrimidinic endonuclease 1 (APE1). The strategy combined with a ternary ECL sensing platform achieved sensitive analysis of APE1 with a linear range of 1 x 10-8 to 1 x 10-2 U/μL and a detection limit of 2.29 x 10-9 U/μL. This study provides a new method for the early diagnosis of cancer. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SENSORS AND ACTUATORS B-CHEMICAL</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82881682/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83735384" class="text-dark hover-underline">Localized Cas12a-based cascade amplification for sensitive and robust detection of APE1</a> </h4> <p class="text-ellipsis-2">Lifeng Zhang, Shihua Luo, Rui Fan, Ruixi Li, Wenbin Li, Siting Chen, Fei Lan, Yitong Zhu, Tingting Ji, Ye Zhang, Ling Li</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7745.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study presents a novel localized Cas12a-based cascade amplification method for detecting APE1 in cancer. The method confines enzymes to the surface of gold nanoparticles, improving stability and sensitivity, with a detection limit as low as 2.51 x 10-6 U/ mL, and shows resistance ability in extreme environments, effective for APE1 detection in clinical samples. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">TALANTA</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83735384/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82994499" class="text-dark hover-underline">Ultrasound-triggered cascade reaction via MnO2-CpG nanoparticles for boosting pyroptosis-mediated cancer immunotherapy</a> </h4> <p class="text-ellipsis-2">Xingang Wang, Ming Shen, Yingying Sun, Qianyun Tang, Ling Du, Shuai Yang, Hanbing Zou, Xue Zhao, Xiaojing Chen, Huishan Li, Junru Li, Xinghui Wang, Lifeng Lao, Dayong Yang, Bin Gu, Peifeng Liu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/6034.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study constructs MnO2-CpG nanoparticles that can regulate the tumor microenvironment and enhance the anti-tumor immune response. Combined with ultrasound irradiation, it has various amplification effects, activates the pyroptosis signaling pathway, releases immunostimulatory agents, and further enhances the immune response, providing a new strategy for cancer immunotherapy. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">NANO TODAY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82994499/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/27525482" class="text-dark hover-underline">Electrochemical determination of Pb2+based on DNAzyme-triggered rolling circle amplification and DNA-templated silver nanoclusters amplification strategy</a> </h4> <p class="text-ellipsis-2">Yingqin Zhang, Ying Liao, Xuehu Yin, Yanli Zhang, Zhi Yang, Hongbin Wang, Wenrong Yang, Pengfei Pang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/5871.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> An electrochemical biosensor based on rolling circle amplification (RCA) was developed for the detection of lead ion (Pb2+). The biosensor utilized Pb2+-dependent DNAzyme and DNA-templated silver nanoclusters (DNA-AgNCs) for amplification, and showed high sensitivity and selectivity for Pb2+ analysis in the range of 1 pM-10 μM with a detection limit of 0.3 pM. This strategy has potential applications in real water samples and environment analysis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">MICROCHEMICAL JOURNAL</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/27525482/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Spectroscopy </span> </div> <h4> <a href="https://www.peeref.com/zh/works/25486398" class="text-dark hover-underline">Cascade amplification strategy combined with analyte-triggered fluorescence switching of dual-quenching system for highly sensitive detection of isoniazide</a> </h4> <p class="text-ellipsis-2">Ya-Nan Zuo, Yinghui Xia, Yanyu Li, Jing Sun, Xian-En Zhao, Shuyun Zhu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7602.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A sensitive fluorescence sensing platform has been developed using manganese dioxide nanosheets and gold nanoparticles as dual nanoquenchers to detect isoniazid. The fluorescence of 2,3-diaminophenazine is simultaneously quenched by MnO2 and AuNPs, and is recovered through analyte-triggered cascade reactions. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/25486398/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83083332" class="text-dark hover-underline">Dual-quenching molecular imprinting polymers electrochemiluminescence sensor for diuron detection: triggered by blocking effect and interaction of diuron with Triethylamine</a> </h4> <p class="text-ellipsis-2">Yan Wang, Xiaohong Liu, Yinhui Yi, Yi He, Meiyang Zhen, Qijian Niu, Xiaofeng Wu, Libo Li, Tianyan You</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7475.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel dual-quenching MIP-ECL sensor was fabricated for high-performance analysis of diuron. The sensor combined the blocking effect of MIPs and the competitive reaction between diuron and coreactant. By immobilizing AuNCs and introducing MIP, the sensor detected diuron through its hindrance of electron transfer and consumption of coreactant. The sensor showed excellent analytical performance and provided a new method for diuron detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SENSORS AND ACTUATORS B-CHEMICAL</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83083332/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Applied </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28370205" class="text-dark hover-underline">Allosteric probe-triggered isothermal amplification to activate CRISPR/Cas12a for sensitive electrochemiluminescence detection of Salmonella</a> </h4> <p class="text-ellipsis-2">Chunyan Wang, Yutian Zhang, Shanshan Liu, Yashi Yin, Gao-Chao Fan, Yizhong Shen, Heyou Han, Wenjing Wang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/2892.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> We developed an ECL sensor for Salmonella detection using allosteric probe as a bio-recognition element and CRISPR/Cas12a as a signal amplification strategy. The presence of Salmonella triggers structure switching on allosteric probes, leading to isothermal amplification. The released Salmonella initiates the next reaction cycle, generating dsDNA recognized by CRISPR-gRNA to activate Cas12a for trans-cleavage. The activated Cas12a cuts ssDNA bound to the electrode, resulting in the release of ECL emitter MOF and decreased ECL signal. The method shows high sensitivity in detecting Salmonella in real samples. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">FOOD CHEMISTRY</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28370205/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biophysics </span> </div> <h4> <a href="https://www.peeref.com/zh/works/28243774" class="text-dark hover-underline">Selenium and nitrogen co-doped carbon dots with highly efficient electrochemiluminescence for ultrasensitive detection of microRNA</a> </h4> <p class="text-ellipsis-2">Jie Liu, Jie Chen, Yue Zhang, Linlei Liu, Yuzhuo Guo, Ruo Yuan, Yaqin Chai</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/1203.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> In this study, selenium and nitrogen co-doped carbon dots (SeN-CDs) were synthesized as a new emitter with highly efficient electrochemiluminescence (ECL) and excellent biocompatibility for sensitive detection of microRNA-221 (miRNA-221). The SeN-CDs exhibited superior ECL performance compared to N-doped CDs, with selenium playing a key role in enhancing the ECL efficiency. The biosensor constructed using the SeN-CDs and a T7 Exo-assisted double cycle amplification strategy achieved ultrasensitive detection of miRNA-221, with a low detection limit of 2.3 aM. This work provides a novel method to enhance the ECL performance of carbon dots for the development of sensitive biosensing platforms for biomarker detection and disease diagnosis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOSENSORS &amp; BIOELECTRONICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/28243774/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82482222" class="text-dark hover-underline">Strand displacement amplification triggered 3D DNA roller assisted CRISPR/Cas12a electrochemiluminescence cascaded signal amplification for sensitive detection of Ec-16S rDNA</a> </h4> <p class="text-ellipsis-2">Shujing Wang, Yaqi Liu, Ruifang Liu, Li Xie, Hongmei Yang, Shenguang Ge, Jinghua Yu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/514.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper constructs an ECL biosensor based on CRISPR/Cas12a technology and cascade signal amplification strategy for the detection of Ec-16S rDNA. The sensor has high sensitivity and low detection limit, and can achieve exponential amplification of the target signal. MnO2 NFs as a co-reaction promoter enhanced the ECL intensity. This study provides a new idea for the detection of Ec-16S rDNA in disease diagnosis and clinical analysis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICA CHIMICA ACTA</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82482222/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/81684926" class="text-dark hover-underline">Dual miRNA-Triggered DNA Walker Assisted by APE1 for Specific Recognition of Tumor Cells</a> </h4> <p class="text-ellipsis-2">Qianying Zhou, Tong Li, Xidong Li, Lintao Wei, Jiaxin Luo, Lingling Bai, Wen-Jun Duan, Baoping Xie, Bin Sun, Jin-Xiang Chen, Zong Dai, Jun Chen</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/518.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed a dual miRNA-triggered DNA walker (DMTDW) assisted by APE1 for the specific recognition of tumor cells. The strategy is highly sensitive, rapid, and accurate, and can effectively respond to the fluctuation of miRNA and specifically identify MDA-MB-231 cells from different cell lines. The study believes that the DMTDW strategy can become a powerful diagnostic tool for the specific recognition of tumor cells. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/81684926/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biophysics </span> </div> <h4> <a href="https://www.peeref.com/zh/works/25265945" class="text-dark hover-underline">Catalytic hairpin self-assembly regulated chameleon silver nanoclusters for the ratiometric detection of CircRNA</a> </h4> <p class="text-ellipsis-2">Min Yang, Hongyu Li, Xiangyang Li, Kunlun Huang, Wentao Xu, Longjiao Zhu</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/1203.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> CircRNA, as an important biomarker for cancer diagnosis and prognosis, can be sensitively and selectively detected using an isothermal amplification system based on CHA and DNA-AgNCs. This system enables label-free ratio metric detection of circRNA. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOSENSORS &amp; BIOELECTRONICS</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/25265945/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83770740" class="text-dark hover-underline">Highly sensitive electrochemiluminescence sensing platform based on copper nanoclusters synthesized via a DNA nanoribbon template for the detection of cancer cells</a> </h4> <p class="text-ellipsis-2">Fangfang Chen, Yukun Xing, Mengyan Lei, Le Li, Lan Luo, Jixiang Liu, Xinya Yang, Xiaoqing He, Jiangshan Xue, Huaiyu Bu, Yuan He, Xiangyuan Ouyang</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7475.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A copper nanocluster-based electrochemiluminescence biosensor was developed for the detection of cancer cells and their surface proteins. The sensor uses DNA nanoribbon templates to synthesize copper nanoclusters, combined with target cycle amplification technology, to improve the detection sensitivity and specificity. This method can detect MUC1 protein in a wide concentration range and successfully detect MCF-7 cancer cells. This study provides a new idea and method for the highly sensitive detection of living cells and their associated surface proteins. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">SENSORS AND ACTUATORS B-CHEMICAL</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83770740/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Multidisciplinary </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82523862" class="text-dark hover-underline">Pyrenecarboxaldehyde@Graphene Oxide Acted as a Highly Efficient ECL Emitter and Target-Triggered the Recyclable Cascade System as an Amplifier for Ultrasensitive APE1 Activity Detection</a> </h4> <p class="text-ellipsis-2">Duo-Duo Chai, Ying Zhuo, Mei-Ling Zhao, Hong-Ling Li, Ruo Yuan, Sha-Ping Wei</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/10311.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed a novel ECL biosensing platform for ultrasensitive assessment of APE1 activity by non-covalent combination of pyrenecarboxaldehyde@graphene oxide sheets. The platform forms stable polar functional groups on the surface of GO sheets through non-covalent π-π stacking mechanism, reducing internal filtering effects and non-activated emitters, and enhancing ECL intensity. In addition, APE1-activated initiators can trigger a recyclable cascade amplification system based on the synergistic cross-activation between catalytic hairpin assembly and DNAzyme, improving signal amplification and transduction ability. The platform has excellent sensitivity and a low detection limit, and holds great promise for the future development of sensitive and reliable biosensing platforms. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ACS SENSORS</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82523862/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Biophysics </span> </div> <h4> <a href="https://www.peeref.com/zh/works/34038170" class="text-dark hover-underline">Target-triggered cascade signal amplification in nanochannels: An ingenious strategy for ultrasensitive photoelectrochemical DNA bioanalysis</a> </h4> <p class="text-ellipsis-2">Ze Hu, Hao Wang, Huimin Chen, Gao-Chao Fan, Xiliang Luo</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/1203.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> In this study, an ingenious approach of target-triggered cascade signal amplification in porous anodic aluminum oxide nanochannels was developed for ultrasensitive photoelectrochemical DNA bioanalysis. The innovative nanochannels PEC strategy launched a novel detecting platform for trace levels of DNA, providing a potential inspiration for other smart nanochannels PEC bioassays. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">BIOSENSORS &amp; BIOELECTRONICS</span> (2023) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/34038170/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/25489582" class="text-dark hover-underline">Label-free and highly sensitive APE1 detection based on rolling circle amplification combined with G-quadruplex</a> </h4> <p class="text-ellipsis-2">Birong Liu, Zizhong Yang, Ting Huang, Min-Min Li, Wenjun Duan, Baoping Xie, Jin-Xiang Chen, Zong Dai, Jun Chen</p> <div class="d-flex mb-3"> <div class="flex-shrink-0 d-none d-sm-block"> <img src="https://peeref-open.s3.amazonaws.com/storage/images/covers/7745.jpg" alt="" class="border mr-3" width="100"> </div> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A highly sensitive and label-free APE1 fluorescence detection method based on rolling circle amplification combined with G-quadruplex has been developed, successfully applicable for detecting APE1 in serum samples with a high recovery rate. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">TALANTA</span> (2022) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/25489582/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> <div id="articles_from_authors" class="tab-pane "> <div class="nodata my-4">暂无数据</div> </div> <div id="articles_from_journal" class="tab-pane "> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83077947" class="text-dark hover-underline">Ultrasensitive and Wash-Free Detection of Tumor Extracellular Vesicles by Aptamer-Proximity-Ligation-Activated Rolling Circle Amplification Coupled to Single Particle ICP-MS</a> </h4> <p class="text-ellipsis-2">Xue-Wei Zhang, Gong-Xiang Qi, Shuai Chen, Yong-Liang Yu, Jian-Hua Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study developed an aptamer-proximity-ligation-activated rolling circle amplification (RCA) method for EV membrane recognition, combined with single particle inductively coupled plasma mass spectrometry (sp-ICP-MS) for the quantification of TEVs. The method has excellent sensitivity and selectivity, can detect TEVs in a wash-free manner, and has high accuracy in distinguishing cancer patients from healthy donors. The method is simple and fast to operate, and has great potential in the applications of life sciences and personalized medicine. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83077947/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83065451" class="text-dark hover-underline">CRISPR/Cas12a-Responsive Smart DNA Hydrogel for Sensitive Electrochemiluminescence Detection of the Huanglongbing Outer Membrane Protein Gene</a> </h4> <p class="text-ellipsis-2">Yutian Zhang, Can Hu, Yashi Yin, Kejing Ren, Yingsi He, Yanru Gao, Heyou Han, Chengzhou Zhu, Wenjing Wang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel ECL biosensor was reported for the highly sensitive detection of the Omp gene of CLas, which causes citrus Huanglongbing. The biosensor combines RCA with a CRISPR/Cas12a-responsive smart DNA hydrogel. The performance of the biosensor was evaluated with live citrus leaf samples, and the results were in excellent agreement with the qPCR results. The sensing strategy expands the versatility of ECL for detecting different levels of DNA in plants. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83065451/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83027949" class="text-dark hover-underline">Multi-Enzyme Cascade Nanoreactors for High-Throughput Immunoassay: Transitioning Concept in Lab to Application in Community</a> </h4> <p class="text-ellipsis-2">Zhichao Yu, Juan Tang, Man Xu, Di Wu, Yuan Gao, Yongyi Zeng, Xiaolong Liu, Dianping Tang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> In this study, a platinum nanozyme loaded with cholesterol oxidase was constructed and applied to the construction of a nanozyme-enzyme-linked immunosorbent assay model, enabling high-throughput and rapid evaluation of cancer markers. The nanozyme platform exhibited efficient enzyme-like catalytic efficiency and photothermal conversion efficiency, and could be used for the development of multi-enzyme photothermal probes. Systemic temperature evaluations were performed using a handheld microelectromechanical system thermal imager to determine the cancer antigen 15-3 profile in the samples. This study provides a new idea for the development of efficient multi-enzyme portable colorimetric-photothermal platforms, which is helpful for promoting the community-based process of early cancer detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83027949/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83570573" class="text-dark hover-underline">Structure Remodeling Strategy for Open-Cage NiFe@Fe-bis-PBA with Enhanced Peroxidase-like Activity To Monitor Tumor Markers</a> </h4> <p class="text-ellipsis-2">Ruixin Liu, Feng Shi, Haibing Zhu, Kai Liu, Zijun Lai, Yaoyao Li, Zhanjun Yang, Juan Li</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study presents a structural remodeling strategy for the construction of open-cage Fe PBA-anchored NiFePBA nanozymes with significantly enhanced enzyme-mimicking activity. Through detailed studies of their formation processes and mechanisms, it was found that the resulting nanozymes have a special open-cage core-shell structure. These nanozymes can be further used to immobilize secondary antibodies and construct highly sensitive electrochemical immunosensors for monitoring tumor markers. The sensor has a wide linear range and low detection limit, as well as high specificity, acceptable reproducibility, and stability. This work provides a general and promising strategy for remodeling PBA nanozymes, enhancing their enzyme-mimicking properties for applications in different fields. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83570573/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83031084" class="text-dark hover-underline">A Programmable Microfluidic Paper-Based Analytical Device for Simultaneous Colorimetric and Photothermal Visual Sensing of Multiple Enzyme Activities</a> </h4> <p class="text-ellipsis-2">Kailing Li, Jun Wang, Jieqiong Wang, Zhi Zheng, Xinping Liu, Jikai Wang, Chenjing Zhang, Suisui He, Hua Wei, Cui-Yun Yu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study reports a smartphone-assisted programmable microfluidic paper-based analytical device that can simultaneously, accurately, and visually quantitative detect alkaline phosphatase and butyrylcholinesterase. The device utilizes colorimetric and photothermal signals and is based on a two-step bioenzyme-nanzyme cascade reaction, with low detection limits and excellent processability. Through the analysis of clinical serum samples, the practicability and efficiency of the platform have been demonstrated. The platform has great potential in simultaneously detecting multiple enzyme activities in real samples. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83031084/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84045655" class="text-dark hover-underline">Machine Learning-Based Nanozyme Sensor Array as an Electronic Tongue for the Discrimination of Endogenous Phenolic Compounds in Food</a> </h4> <p class="text-ellipsis-2">Wenjie Jing, Yajun Yang, Qihao Shi, Yu Wang, Fufeng Liu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel bifunctional vanillic acid-Cu nanozyme with peroxidase-like and laccase-like activities was successfully fabricated. Based on the nanozyme, a six-channel nanozyme sensor array was constructed for discriminant analysis of nine EPs. Combined with ANN algorithms, accurate identification and prediction of EPs in real samples were achieved. Finally, a portable detection method based on a smartphone was proposed. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84045655/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83088898" class="text-dark hover-underline">Highly Specific Aptamer-Antibody Birecognized Sandwich Module for Ultrasensitive Detection of a Low Molecular Weight Compound</a> </h4> <p class="text-ellipsis-2">Ying Zhou, Yuying Wei, Jia Zhang, Xiaoyu Shi, Liang Ma, Ruo Yuan</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study introduces the aptamer-antibody sandwich module for the first time to accurately recognize low molecular weight compounds. Compared with the traditional dual-antibody module, the sandwich module has high recognition efficiency and can reduce false positives and false negatives. Based on this, a sensitive electrochemiluminescence biosensor was constructed for the detection of mycotoxin zearalenone. The sensor has a low detection limit and high sensitivity, and has great application potential in food analysis, environmental monitoring, and clinical diagnosis. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83088898/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83121104" class="text-dark hover-underline">Steric Hindrance-Mediated Enzymatic Reaction Enable Homogeneous Dual Fluorescence Indicators Aptasensing of Hepatocellular Carcinoma CTCs</a> </h4> <p class="text-ellipsis-2">Pengjun Jiang, Zixuan Zhan, Yufu Peng, Chengyong Wu, Yue Wang, Longfei Wu, Shiya Shi, Binwu Ying, Yonggang Wei, Piaopiao Chen, Jie Chen</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study describes a dual fluorescence indicator aptasensing strategy for CTCs in HCC, which eliminates the steric hindrance to affect the efficiency of the enzymatic reaction for quantitative analysis of CTCs. The system shows high sensitivity and specificity in the analysis of clinical samples, which is helpful for the early diagnosis of tumors. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83121104/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83123857" class="text-dark hover-underline">Label-Free and DNAzyme-Mediated Biosensor with a High Signal-to-Noise Ratio for a Lumpy Skin Disease Virus Assay</a> </h4> <p class="text-ellipsis-2">Gaihua Cao, Nannan Yang, Jun Yang, Jiali Li, Lin Wang, Fuping Nie, Danqun Huo, Changjun Hou</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper introduces a novel label-free fluorescence method for the detection of lumpy skin disease virus (LSDV). Based on a light-up RNA aptamer, the method integrates recombinase polymerase amplification (RPA), CRISPR/Cas12a, 10-23 DNAzyme, and Baby Spinach RNA aptamer for triple cascade signal amplification. The method has ultrahigh sensitivity and specificity, with a practical detection limit of 1.29 copies μL-1 and 100 times higher sensitivity than RPA with Cas12a. In addition, the method has no cross-reactivity with other viruses and shows 100% accuracy in actual samples. Therefore, the method provides a new solution for the detection and prevention and control of LSDV. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83123857/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84294609" class="text-dark hover-underline">Highly Sensitive One-Pot Isothermal Assay Combining Rolling Circle Amplification and CRISPR/Cas12a for Aflatoxin B1 Detection</a> </h4> <p class="text-ellipsis-2">Xinxin Zhao, Zhongxing Wang, Hao Zhang, Jinpeng Liu, Wenli Wu, Li Yu, Chuanlai Xu, Xiao Wang, Qiongzheng Hu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> A novel one-pot isothermal assay integrating RCA and CRISPR/Cas12a is reported for the detection of AFB1. The assay is ultrasensitive and can be visualized, and has been successfully applied to real samples with satisfactory recoveries. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84294609/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84384829" class="text-dark hover-underline">Near-Infrared Unimolecular Chemiluminescence Probes for Deep-Tissue Imaging</a> </h4> <p class="text-ellipsis-2">Ling Li, Xinyi Zhang, Yuxin Ren, Meiqi Li, Benkai Bao, Junqing Wang, Mengpan Zhang, Yanli Tang</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> Chemiluminescence imaging has minimal background autofluorescence and no excitation, making it a promising optical imaging technique. However, the emission of most chemiluminescent probes is concentrated in the visible light region, limiting tissue penetration. Although some NIR chemiluminescent probes have been reported based on the CRET strategy, energy loss is inevitable. Therefore, it is crucial to develop NIR unimolecular probes with direct chemiluminescence. This study proposes a strategy of increasing conjugation for designing and synthesizing novel NIR chemiluminescence unimolecular probes, and investigates their direct CL mechanism. Compared with CRET-based chemiluminescence, this direct CL avoids energy loss and is more conducive to converting chemical energy into chemiluminescence. The study also prepares corresponding nanoparticles and successfully applies them to in vivo chemiluminescence imaging of various inflammation models. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84384829/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83146594" class="text-dark hover-underline">Bioreaction-Compatible Bivariate Lanthanide MOF Sensor Enables Stimulus-Multiresponsive Platform for ctDNA On-Site Detection</a> </h4> <p class="text-ellipsis-2">Yumin Feng, Long Yu, Qi Xu, Zhongyu Wei, Zhiwen Gan, Xilin Nie, Yuxiu Xiao</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper presents a novel circulating tumor DNA (ctDNA) detection platform in liquid biopsy based on a newly designed bivariable lanthanide metal-organic framework (Ln-MOF). The platform detects ctDNA by quantifying the by-product pyrophosphate (PPi) of DNA amplification and combines with the isothermal nucleic acid exponential amplification reaction (EXPAR), achieving the advantages of low cost, convenience, sensitivity, and suitability for on-site detection. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83146594/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/84093256" class="text-dark hover-underline">CRISPR-Responsive RCA-Based DNA Hydrogel Biosensing Platform with Customizable Signal Output for Rapid and Sensitive Nucleic Acid Detection</a> </h4> <p class="text-ellipsis-2">Yan Zhang, Weiwei Wang, Xinxi Zhou, Haonan Lin, Xiaotong Zhu, Yongliang Lou, Laibao Zheng</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This paper presents a novel biosensing platform that integrates the CRISPR/Cas12a system into an RCA-based DNA hydrogel, addressing the challenges faced by current nucleic acid-responsive DNA hydrogels in biosensing applications. The platform demonstrates high specificity and sensitivity, enabling rapid and accurate detection of the mecA gene in clinical samples, and holds great promise for future applications. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/84093256/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 border-bottom"> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/83012837" class="text-dark hover-underline">Enhancing Kinase Activity Detection with a Programmable Lanthanide Metal-Organic Framework via ATP-to-ADP Conversion</a> </h4> <p class="text-ellipsis-2">Long Yu, Yongjin Shen, Qi Xu, Zhiwen Gan, Yumin Feng, Chunxu Yang, Yuxiu Xiao</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study investigated the interaction between Ln-MOF and phosphate analytes and its application in biosensing. By synthesizing six Eu-MOFs and selecting Eu-TPTC as a fluorescent probe, high-precision detection of creatine kinase activity was achieved. This research provides a new idea for kinase activity assays and demonstrates the application potential of Ln-MOF in analytical chemistry. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/83012837/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> <div class="my-4 "> <div> <span class="d-inline-block badge badge-blue"> Article </span> <span class="d-inline-block badge badge-cyan"> Chemistry, Analytical </span> </div> <h4> <a href="https://www.peeref.com/zh/works/82951368" class="text-dark hover-underline">Ultrasensitive Paper-Based Photoelectrochemical Biosensor for Acetamiprid Detection Enabled by Spin-State Manipulation and Polarity-Switching</a> </h4> <p class="text-ellipsis-2">Yuanyuan Chen, Jiaxin Liang, Jiahui Xu, Li Shan, Jingjing Lv, Chengjun Wu, Lina Zhang, Li Li, Jinghua Yu</p> <div class="d-flex mb-3"> <div class="p-3 rounded bg-light-blue"> <strong>Summary:</strong> This study improved the carrier separation efficiency of the photoactive matrix by regulating the electron spin state and designing the electron transport path, thereby enhancing the detection sensitivity of the PEC biosensor. The sensor shows high selectivity and sensitivity for the detection of acetamiprid, with a wide linear range and a low detection limit, and has great application potential. </div> </div> <div class="d-flex justify-content-between"> <p class="font-weight-bold"> <span class="text-primary">ANALYTICAL CHEMISTRY</span> (2024) </p> <div class="flex-shrink-0"> <a class="btn btn-outline-primary btn-sm" href="https://www.peeref.com/zh/works/82951368/add-to-collection" target="_blank"> <strong>添加到收藏夹</strong> </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="modal fade" id="export-citation" tabindex="-1"> <div class="modal-dialog"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal"><span>&times;</span></button> <h4 class="modal-title">导出引文 <b class="text-primary"></b></h4> </div> <div class="modal-body"> <div class="my-3 px-4 f16"> <form action="https://www.peeref.com/zh/works/citation/download" 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