CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>European Research Papers - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "by_tag", 'action': "show_one", 'controller_action': 'by_tag#show_one', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="almACYB4wkNRH5gCgKlkcZxyiy3_rgnEjhICH8r_BI7UT-tkgwbJ0_wnG1_Lk5yBUgVORHIp0coyYZFxzGiY_w" /> <link href="/Documents/in/European?after=50%2C33259510" rel="next" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="description" content="View European Research Papers on Academia.edu for free." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'by_tag'; var $action_name = "show_one"; var $rails_env = 'production'; var $app_rev = '1363409c2f6920b9f6129801bf9c25a45dc9d4a3'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14023,"monthly_visitors":"102 million","monthly_visitor_count":102584291,"monthly_visitor_count_in_millions":102,"user_count":283361049,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1740152519000); window.Aedu.timeDifference = new Date().getTime() - 1740152519000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-1eb081e01ca8bc0c1b1d866df79d9eb4dd2c484e4beecf76e79a7806c72fee08.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-b42d48e01e9cb3bf5ae55ea154ab7133fe47240c1d7c59b0249065c67d6f65ab.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-f3fdf92d2e211a3fd7a717a75adb7bf4af30f5d7651964d9f223129f218112cd.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://www.academia.edu/Documents/in/European" /> </head>   <body class='c-by_tag a-show_one logged_out u-bgColorWhite'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav no-sm no-md"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <div class="DesignSystem" style="margin-top:-40px"><div class="PageHeader"><div class="container"><div class="row"><style type="text/css">.sor-abstract { display: -webkit-box; overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">European</h1><div class="u-tcGrayDark">21,930 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>European</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/European">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/European/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/European/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/European/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/European">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48645050" data-work_id="48645050" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48645050/A_soluble_single_chain_Kd_molecule_produced_by_yeast_selects_a_peptide_repertoire_indistinguishable_from_that_of_cell_surface_associated_Kd">A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd Peptide binding to a soluble, single-chain Kd protein produced by the yeast strain Kfuyverumyces... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_48645050" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd Peptide binding to a soluble, single-chain Kd protein produced by the yeast strain Kfuyverumyces lactis, and to Kd molecules on Kd-expressing cells (P815) was studied using radiolabeled Kd-restricted peptides. The stability of the peptide-Kd complexes formed was monitored in the absence and presence of unlabeled competitor peptides. Radioiodination of the Tyr anchor residue in position 2 of the peptide interferes with binding. A Kd-biased peptide library apd a modified antigenic peptide in which a second Tyr was added in positions 6 and 8, respectively, were therefore used to assay binding. Recombinant and cellassociated Kd molecules are very similar in the following respects: the ease with which the proteins can be loaded with labeled peptide; the spectrum of peptides selected from a peptide library; the stability of the labeled peptide-Kd complex formed; and the ability to partially dissociate the class I-peptide complex with exogenous, unlabeled peptides. These results imply that measurements of peptide binding to soluble Kd molecules are a reliable indicator of the peptide-binding properties of Kd proteins on living cells. The large quantities of soluble recombinant Kd protein currently available represent an invaluable tool not only for dissecting the molecular mechanisms of antigen presentation but also for vaccinations and the design of T cell-specific toxins.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48645050" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0a19f3f579b540d456cec1ba4136df97" rel="nofollow" data-download="{"attachment_id":67150241,"asset_id":48645050,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67150241/download_file?st=MTc0MDE1MjUxNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46070982" href="https://independent.academia.edu/JeanpierreAbastado">Jean pierre Abastado</a><script data-card-contents-for-user="46070982" type="text/json">{"id":46070982,"first_name":"Jean pierre","last_name":"Abastado","domain_name":"independent","page_name":"JeanpierreAbastado","display_name":"Jean pierre Abastado","profile_url":"https://independent.academia.edu/JeanpierreAbastado?f_ri=279027","photo":"https://0.academia-photos.com/46070982/124163211/113517561/s65_jean_pierre.abastado.jpeg"}</script></span></span></li><li class="js-paper-rank-work_48645050 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48645050"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48645050, container: ".js-paper-rank-work_48645050", }); });</script></li><li class="js-percentile-work_48645050 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48645050; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48645050"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48645050 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48645050"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48645050; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48645050]").text(description); $(".js-view-count-work_48645050").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48645050").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48645050"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" rel="nofollow" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="135250" rel="nofollow" href="https://www.academia.edu/Documents/in/Antigen_Presentation">Antigen Presentation</a>, <script data-card-contents-for-ri="135250" type="text/json">{"id":135250,"name":"Antigen Presentation","url":"https://www.academia.edu/Documents/in/Antigen_Presentation?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="435727" rel="nofollow" href="https://www.academia.edu/Documents/in/Major_histocompatibility_complex">Major histocompatibility complex</a><script data-card-contents-for-ri="435727" type="text/json">{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48645050]'), work: {"id":48645050,"title":"A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd","created_at":"2021-05-05T01:47:31.415-07:00","url":"https://www.academia.edu/48645050/A_soluble_single_chain_Kd_molecule_produced_by_yeast_selects_a_peptide_repertoire_indistinguishable_from_that_of_cell_surface_associated_Kd?f_ri=279027","dom_id":"work_48645050","summary":"A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd Peptide binding to a soluble, single-chain Kd protein produced by the yeast strain Kfuyverumyces lactis, and to Kd molecules on Kd-expressing cells (P815) was studied using radiolabeled Kd-restricted peptides. The stability of the peptide-Kd complexes formed was monitored in the absence and presence of unlabeled competitor peptides. Radioiodination of the Tyr anchor residue in position 2 of the peptide interferes with binding. A Kd-biased peptide library apd a modified antigenic peptide in which a second Tyr was added in positions 6 and 8, respectively, were therefore used to assay binding. Recombinant and cellassociated Kd molecules are very similar in the following respects: the ease with which the proteins can be loaded with labeled peptide; the spectrum of peptides selected from a peptide library; the stability of the labeled peptide-Kd complex formed; and the ability to partially dissociate the class I-peptide complex with exogenous, unlabeled peptides. These results imply that measurements of peptide binding to soluble Kd molecules are a reliable indicator of the peptide-binding properties of Kd proteins on living cells. The large quantities of soluble recombinant Kd protein currently available represent an invaluable tool not only for dissecting the molecular mechanisms of antigen presentation but also for vaccinations and the design of T cell-specific toxins.","downloadable_attachments":[{"id":67150241,"asset_id":48645050,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46070982,"first_name":"Jean pierre","last_name":"Abastado","domain_name":"independent","page_name":"JeanpierreAbastado","display_name":"Jean pierre Abastado","profile_url":"https://independent.academia.edu/JeanpierreAbastado?f_ri=279027","photo":"https://0.academia-photos.com/46070982/124163211/113517561/s65_jean_pierre.abastado.jpeg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=279027","nofollow":true},{"id":135250,"name":"Antigen Presentation","url":"https://www.academia.edu/Documents/in/Antigen_Presentation?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":435727,"name":"Major histocompatibility complex","url":"https://www.academia.edu/Documents/in/Major_histocompatibility_complex?f_ri=279027","nofollow":true},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=279027"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins?f_ri=279027"},{"id":1078292,"name":"Cell Surface Markers","url":"https://www.academia.edu/Documents/in/Cell_Surface_Markers?f_ri=279027"},{"id":1663739,"name":"Tyrosine","url":"https://www.academia.edu/Documents/in/Tyrosine?f_ri=279027"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=279027"},{"id":2739448,"name":"Kluyveromyces","url":"https://www.academia.edu/Documents/in/Kluyveromyces?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62737836" data-work_id="62737836" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62737836/PET_CT_and_breast_cancer">PET/CT and breast cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62737836" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every case the user must check such information by consulting the relevant literature.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62737836" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c2850952fa3819bfac5aa9a3c6689b4c" rel="nofollow" data-download="{"attachment_id":75408775,"asset_id":62737836,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75408775/download_file?st=MTc0MDE1MjUxNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="209462481" href="https://unisr.academia.edu/mariapicchio">maria picchio</a><script data-card-contents-for-user="209462481" type="text/json">{"id":209462481,"first_name":"maria","last_name":"picchio","domain_name":"unisr","page_name":"mariapicchio","display_name":"maria picchio","profile_url":"https://unisr.academia.edu/mariapicchio?f_ri=279027","photo":"https://0.academia-photos.com/209462481/69272897/57669330/s65_maria.picchio.jpg"}</script></span></span></li><li class="js-paper-rank-work_62737836 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62737836"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62737836, container: ".js-paper-rank-work_62737836", }); });</script></li><li class="js-percentile-work_62737836 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 62737836; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_62737836"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_62737836 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="62737836"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 62737836; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=62737836]").text(description); $(".js-view-count-work_62737836").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_62737836").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="62737836"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1648" rel="nofollow" href="https://www.academia.edu/Documents/in/Computed_Tomography">Computed Tomography</a>, <script data-card-contents-for-ri="1648" type="text/json">{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6802" rel="nofollow" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" rel="nofollow" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23518" rel="nofollow" href="https://www.academia.edu/Documents/in/Positron_Emission_Tomography">Positron Emission Tomography</a><script data-card-contents-for-ri="23518" type="text/json">{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=62737836]'), work: {"id":62737836,"title":"PET/CT and breast cancer","created_at":"2021-11-30T01:59:23.765-08:00","url":"https://www.academia.edu/62737836/PET_CT_and_breast_cancer?f_ri=279027","dom_id":"work_62737836","summary":"The use of general descriptive names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every case the user must check such information by consulting the relevant literature.","downloadable_attachments":[{"id":75408775,"asset_id":62737836,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":209462481,"first_name":"maria","last_name":"picchio","domain_name":"unisr","page_name":"mariapicchio","display_name":"maria picchio","profile_url":"https://unisr.academia.edu/mariapicchio?f_ri=279027","photo":"https://0.academia-photos.com/209462481/69272897/57669330/s65_maria.picchio.jpg"}],"research_interests":[{"id":1648,"name":"Computed Tomography","url":"https://www.academia.edu/Documents/in/Computed_Tomography?f_ri=279027","nofollow":true},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=279027","nofollow":true},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=279027","nofollow":true},{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=279027","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=279027"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=279027"},{"id":532278,"name":"Cancer Patient","url":"https://www.academia.edu/Documents/in/Cancer_Patient?f_ri=279027"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=279027"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=279027"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=279027"},{"id":784086,"name":"Radiopharmaceuticals","url":"https://www.academia.edu/Documents/in/Radiopharmaceuticals?f_ri=279027"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=279027"},{"id":1779488,"name":"Breast Cancer Diagnosis","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Diagnosis?f_ri=279027"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image?f_ri=279027"},{"id":2463778,"name":"Clinical Trials as Topic","url":"https://www.academia.edu/Documents/in/Clinical_Trials_as_Topic?f_ri=279027"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_6408155" data-work_id="6408155" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/6408155/Risk_factors_for_mortality_after_the_Norwood_procedure">Risk factors for mortality after the Norwood procedure</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives: Recent studies have suggested that survival following the Norwood procedure is influenced by anatomy and is worse for patients with hypoplastic left heart syndrome (HLHS), particularly aortic atresia (AA), as compared to other... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6408155" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives: Recent studies have suggested that survival following the Norwood procedure is influenced by anatomy and is worse for patients with hypoplastic left heart syndrome (HLHS), particularly aortic atresia (AA), as compared to other forms of functional single ventricle and systemic outflow tract obstruction. The current study was undertaken to evaluate our recent experience with the Norwood procedure and to evaluate potential predictors of operative and 1-year mortality. Methods: A retrospective study of risk factors for operative and 1-year mortality in 158 patients undergoing the Norwood procedure between January 1, 1998 and June 30, 2001. Results: HLHS was present in 102 patients (70 with AA) and other forms of functional single ventricle with systemic outflow tract obstruction in the remaining 56. Operative survival was 77% (122/158), 78% for patients with HLHS and 75% for patients with other diagnoses. Multivariable analysis identified birth weight (odds ratio (OR) 0.18/kg, 95% confidence limit (CL) 0.08-0.42, P , 0:001), associated cardiac anomalies (OR 4.45, 95% CL 1.50-13.2, P ¼ 0:001), total support time (OR 1.02/min, 95% CL 1.01-1.03, P ¼ 0:004), and extracorporeal membrane oxygenation (ECMO) or ventricular assist device (VAD) support (OR 17.8, 95% CL 4.40-71.0, P , 0:001) as predictors of operative mortality. The anatomic diagnosis (HLHS versus non-HLHS) was not a predictor of mortality, P ¼ 0:6). The Kaplan-Meier survival estimate at 1 year was 66% (95% CL 58-73%) and was not different for patients with HLHS compared to non-HLHS, P ¼ 0:5. For patients who have survived the Norwood procedure, survival to 1 year was 86% (95% CL 78-91%). Presence of an extra-cardiac anomaly or genetic syndrome (OR 2.70, 95% CL 0.98-7.41%, P ¼ 0:05) and presence of an additional cardiac defect (OR 3.99, 95% CL 1.67-9.57, P ¼ 0:002) were predictors of worse survival in the first year of life. Conclusions: The Norwood procedure is currently being applied to a heterogeneous group of patients. Operative and 1-year survival are equivalent for patients with HLHS and those with other cardiac defects. The presence of additional cardiac or extra-cardiac anomalies are predictors of poor outcome. q</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6408155" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c62ede3bb522fe953c756ac338203bcf" rel="nofollow" data-download="{"attachment_id":48880517,"asset_id":6408155,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48880517/download_file?st=MTc0MDE1MjUxNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10077507" rel="nofollow" href="https://azburncenter.academia.edu/MitchellCohen">Mitchell Cohen</a><script data-card-contents-for-user="10077507" type="text/json">{"id":10077507,"first_name":"Mitchell","last_name":"Cohen","domain_name":"azburncenter","page_name":"MitchellCohen","display_name":"Mitchell Cohen","profile_url":"https://azburncenter.academia.edu/MitchellCohen?f_ri=279027","photo":"https://0.academia-photos.com/10077507/3119553/3672322/s65_mitchell.cohen.png"}</script></span></span></li><li class="js-paper-rank-work_6408155 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6408155"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6408155, container: ".js-paper-rank-work_6408155", }); });</script></li><li class="js-percentile-work_6408155 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 6408155; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_6408155"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_6408155 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="6408155"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 6408155; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=6408155]").text(description); $(".js-view-count-work_6408155").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_6408155").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="6408155"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41482" rel="nofollow" href="https://www.academia.edu/Documents/in/Multivariate_Analysis">Multivariate Analysis</a>, <script data-card-contents-for-ri="41482" type="text/json">{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47155" rel="nofollow" href="https://www.academia.edu/Documents/in/Birth_Weight">Birth Weight</a><script data-card-contents-for-ri="47155" type="text/json">{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6408155]'), work: {"id":6408155,"title":"Risk factors for mortality after the Norwood procedure","created_at":"2014-03-14T00:18:31.042-07:00","url":"https://www.academia.edu/6408155/Risk_factors_for_mortality_after_the_Norwood_procedure?f_ri=279027","dom_id":"work_6408155","summary":"Objectives: Recent studies have suggested that survival following the Norwood procedure is influenced by anatomy and is worse for patients with hypoplastic left heart syndrome (HLHS), particularly aortic atresia (AA), as compared to other forms of functional single ventricle and systemic outflow tract obstruction. The current study was undertaken to evaluate our recent experience with the Norwood procedure and to evaluate potential predictors of operative and 1-year mortality. Methods: A retrospective study of risk factors for operative and 1-year mortality in 158 patients undergoing the Norwood procedure between January 1, 1998 and June 30, 2001. Results: HLHS was present in 102 patients (70 with AA) and other forms of functional single ventricle with systemic outflow tract obstruction in the remaining 56. Operative survival was 77% (122/158), 78% for patients with HLHS and 75% for patients with other diagnoses. Multivariable analysis identified birth weight (odds ratio (OR) 0.18/kg, 95% confidence limit (CL) 0.08-0.42, P , 0:001), associated cardiac anomalies (OR 4.45, 95% CL 1.50-13.2, P ¼ 0:001), total support time (OR 1.02/min, 95% CL 1.01-1.03, P ¼ 0:004), and extracorporeal membrane oxygenation (ECMO) or ventricular assist device (VAD) support (OR 17.8, 95% CL 4.40-71.0, P , 0:001) as predictors of operative mortality. The anatomic diagnosis (HLHS versus non-HLHS) was not a predictor of mortality, P ¼ 0:6). The Kaplan-Meier survival estimate at 1 year was 66% (95% CL 58-73%) and was not different for patients with HLHS compared to non-HLHS, P ¼ 0:5. For patients who have survived the Norwood procedure, survival to 1 year was 86% (95% CL 78-91%). Presence of an extra-cardiac anomaly or genetic syndrome (OR 2.70, 95% CL 0.98-7.41%, P ¼ 0:05) and presence of an additional cardiac defect (OR 3.99, 95% CL 1.67-9.57, P ¼ 0:002) were predictors of worse survival in the first year of life. Conclusions: The Norwood procedure is currently being applied to a heterogeneous group of patients. Operative and 1-year survival are equivalent for patients with HLHS and those with other cardiac defects. The presence of additional cardiac or extra-cardiac anomalies are predictors of poor outcome. q","downloadable_attachments":[{"id":48880517,"asset_id":6408155,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10077507,"first_name":"Mitchell","last_name":"Cohen","domain_name":"azburncenter","page_name":"MitchellCohen","display_name":"Mitchell Cohen","profile_url":"https://azburncenter.academia.edu/MitchellCohen?f_ri=279027","photo":"https://0.academia-photos.com/10077507/3119553/3672322/s65_mitchell.cohen.png"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=279027","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=279027","nofollow":true},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=279027","nofollow":true},{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight?f_ri=279027","nofollow":true},{"id":88113,"name":"Left Ventricular Assist Device","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Assist_Device?f_ri=279027"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=279027"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=279027"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":372494,"name":"Kaplan-Meier","url":"https://www.academia.edu/Documents/in/Kaplan-Meier?f_ri=279027"},{"id":442734,"name":"First Year","url":"https://www.academia.edu/Documents/in/First_Year?f_ri=279027"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=279027"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=279027"},{"id":990198,"name":"Retrospective Study","url":"https://www.academia.edu/Documents/in/Retrospective_Study?f_ri=279027"},{"id":1228884,"name":"Confidence Limit","url":"https://www.academia.edu/Documents/in/Confidence_Limit?f_ri=279027"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=279027"},{"id":1588897,"name":"Hypoplastic Left Heart Syndrome","url":"https://www.academia.edu/Documents/in/Hypoplastic_Left_Heart_Syndrome?f_ri=279027"},{"id":2328629,"name":"Extracorporeal Membrane Oxygenation","url":"https://www.academia.edu/Documents/in/Extracorporeal_Membrane_Oxygenation?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31029775" data-work_id="31029775" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31029775/Cells_mediators_and_Toll_like_receptors_in_COPD">Cells, mediators and Toll-like receptors in COPD</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Chronic obstructive pulmonary disease (COPD) is a global health problem. Being a progressive disease characterized by inflammation, it deteriorates pulmonary functioning. Research has focused on airway inflammation, oxidative stress, and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_31029775" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Chronic obstructive pulmonary disease (COPD) is a global health problem. Being a progressive disease characterized by inflammation, it deteriorates pulmonary functioning. Research has focused on airway inflammation, oxidative stress, and remodelling of the airways. Macrophages, neutrophils and T cells are thought to be important key players. A number of new research topics received special attention in the last years. The combined use of inhaled corticosteroids and long-acting β 2 -adrenoceptor agonists produces better control of symptoms and lung function than that of the use of either compound alone. Furthermore, collagen breakdown products might be involved in the recruitment and activation of inflammatory cells by which the process of airway remodelling becomes self-sustaining. Also, TLR (Toll-like receptor)-based signalling pathways seem to be involved in the pathogenesis of COPD. These new findings may lead to new therapeutic strategies to stop the process of inflammation and self-destruction in the airways of COPD patients.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31029775" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="917b63ed0b90d6fc6aaa4730323bf128" rel="nofollow" data-download="{"attachment_id":51463716,"asset_id":31029775,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51463716/download_file?st=MTc0MDE1MjUxNyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="59143998" href="https://independent.academia.edu/AnnekeVanHouwelingen">Anneke Van Houwelingen</a><script data-card-contents-for-user="59143998" type="text/json">{"id":59143998,"first_name":"Anneke Van","last_name":"Houwelingen","domain_name":"independent","page_name":"AnnekeVanHouwelingen","display_name":"Anneke Van Houwelingen","profile_url":"https://independent.academia.edu/AnnekeVanHouwelingen?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_31029775 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31029775"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31029775, container: ".js-paper-rank-work_31029775", }); });</script></li><li class="js-percentile-work_31029775 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31029775; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_31029775"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_31029775 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="31029775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31029775; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31029775]").text(description); $(".js-view-count-work_31029775").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31029775").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31029775"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4990" rel="nofollow" href="https://www.academia.edu/Documents/in/Global_Health">Global Health</a>, <script data-card-contents-for-ri="4990" type="text/json">{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9111" rel="nofollow" href="https://www.academia.edu/Documents/in/Cytokines">Cytokines</a>, <script data-card-contents-for-ri="9111" type="text/json">{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="47265" rel="nofollow" href="https://www.academia.edu/Documents/in/Toll_like_receptor_signaling">Toll like receptor signaling</a>, <script data-card-contents-for-ri="47265" type="text/json">{"id":47265,"name":"Toll like receptor signaling","url":"https://www.academia.edu/Documents/in/Toll_like_receptor_signaling?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="48180" rel="nofollow" href="https://www.academia.edu/Documents/in/Toll_Like_Receptors">Toll Like Receptors</a><script data-card-contents-for-ri="48180" type="text/json">{"id":48180,"name":"Toll Like Receptors","url":"https://www.academia.edu/Documents/in/Toll_Like_Receptors?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31029775]'), work: {"id":31029775,"title":"Cells, mediators and Toll-like receptors in COPD","created_at":"2017-01-22T04:06:28.749-08:00","url":"https://www.academia.edu/31029775/Cells_mediators_and_Toll_like_receptors_in_COPD?f_ri=279027","dom_id":"work_31029775","summary":"Chronic obstructive pulmonary disease (COPD) is a global health problem. Being a progressive disease characterized by inflammation, it deteriorates pulmonary functioning. Research has focused on airway inflammation, oxidative stress, and remodelling of the airways. Macrophages, neutrophils and T cells are thought to be important key players. A number of new research topics received special attention in the last years. The combined use of inhaled corticosteroids and long-acting β 2 -adrenoceptor agonists produces better control of symptoms and lung function than that of the use of either compound alone. Furthermore, collagen breakdown products might be involved in the recruitment and activation of inflammatory cells by which the process of airway remodelling becomes self-sustaining. Also, TLR (Toll-like receptor)-based signalling pathways seem to be involved in the pathogenesis of COPD. These new findings may lead to new therapeutic strategies to stop the process of inflammation and self-destruction in the airways of COPD patients.","downloadable_attachments":[{"id":51463716,"asset_id":31029775,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":59143998,"first_name":"Anneke Van","last_name":"Houwelingen","domain_name":"independent","page_name":"AnnekeVanHouwelingen","display_name":"Anneke Van Houwelingen","profile_url":"https://independent.academia.edu/AnnekeVanHouwelingen?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4990,"name":"Global Health","url":"https://www.academia.edu/Documents/in/Global_Health?f_ri=279027","nofollow":true},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=279027","nofollow":true},{"id":47265,"name":"Toll like receptor signaling","url":"https://www.academia.edu/Documents/in/Toll_like_receptor_signaling?f_ri=279027","nofollow":true},{"id":48180,"name":"Toll Like Receptors","url":"https://www.academia.edu/Documents/in/Toll_Like_Receptors?f_ri=279027","nofollow":true},{"id":52736,"name":"Lung Function","url":"https://www.academia.edu/Documents/in/Lung_Function?f_ri=279027"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":295234,"name":"Chemokine","url":"https://www.academia.edu/Documents/in/Chemokine?f_ri=279027"},{"id":379416,"name":"Epithelial cells","url":"https://www.academia.edu/Documents/in/Epithelial_cells?f_ri=279027"},{"id":496709,"name":"Inhaled corticosteroid therapy","url":"https://www.academia.edu/Documents/in/Inhaled_corticosteroid_therapy?f_ri=279027"},{"id":556576,"name":"Chronic obstructive pulmonary disease","url":"https://www.academia.edu/Documents/in/Chronic_obstructive_pulmonary_disease?f_ri=279027"},{"id":677189,"name":"Pulmonary Function","url":"https://www.academia.edu/Documents/in/Pulmonary_Function?f_ri=279027"},{"id":903003,"name":"Chemokines","url":"https://www.academia.edu/Documents/in/Chemokines?f_ri=279027"},{"id":1272099,"name":"Leukocytes","url":"https://www.academia.edu/Documents/in/Leukocytes?f_ri=279027"},{"id":2188946,"name":"Airway Inflammation","url":"https://www.academia.edu/Documents/in/Airway_Inflammation?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_3442521" data-work_id="3442521" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3442521/mtDNA_polymorphisms_in_five_French_groups_importance_of_regional_sampling">mtDNA polymorphisms in five French groups: importance of regional sampling</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">According to classical markers, France has been reported to be regionally heterogeneous. Here, we propose to test the homogeneity of the French mitochondrial gene pool by analysing D-Loop and coding regions polymorphisms in 210... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_3442521" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">According to classical markers, France has been reported to be regionally heterogeneous. Here, we propose to test the homogeneity of the French mitochondrial gene pool by analysing D-Loop and coding regions polymorphisms in 210 individuals stemming from five regions. The data set obtained was also used to test the ability of mitochondrial DNA to detect well historically established admixtures (admixtures between British/Irish people and native Breton people in our case). For these purposes, the sampling procedure was subject to special care, concerning the individuals' geographical origin and maternal pedigree. The mtDNA analysis revealed some regional specificities in haplogroup distribution, which is discussed in terms of successive settlements of France. Statistical analyses were conducted to investigate mtDNA diversity and structure within and between British, Irish and French groups. They tended to show affinities between Morbihan region and Britain plus Ireland. Furthermore, genetic evidences were in line with the fact that Morbihan region results from an admixture event, agreeing with historical evidences of successive migrations from Britain and Ireland into Brittany. These results also tended to outline the fact that two geographically very adjacent samples (Morbihan and Finistère), sharing a cultural and linguistic area, can present a distinct genetic pattern. Although mtDNA analyses were able to identify a historically reported admixture event, we point out here the high influence of the sampling procedure and representativeness over the migrations hypothesis. We also underline the importance of regional sampling for studies on the spread and/or origin of specific European haplogroups (here U5a1a and U8).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3442521" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e50849a72cc55cb907f9230074745741" rel="nofollow" data-download="{"attachment_id":50279404,"asset_id":3442521,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50279404/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4017914" href="https://independent.academia.edu/VincentDubut">Vincent Dubut</a><script data-card-contents-for-user="4017914" type="text/json">{"id":4017914,"first_name":"Vincent","last_name":"Dubut","domain_name":"independent","page_name":"VincentDubut","display_name":"Vincent Dubut","profile_url":"https://independent.academia.edu/VincentDubut?f_ri=279027","photo":"https://0.academia-photos.com/4017914/1526481/1855064/s65_vincent.dubut.jpg"}</script></span></span></li><li class="js-paper-rank-work_3442521 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3442521"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3442521, container: ".js-paper-rank-work_3442521", }); });</script></li><li class="js-percentile-work_3442521 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 3442521; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_3442521"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_3442521 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="3442521"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 3442521; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=3442521]").text(description); $(".js-view-count-work_3442521").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_3442521").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="3442521"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="156" rel="nofollow" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3855" rel="nofollow" href="https://www.academia.edu/Documents/in/Polymorphism">Polymorphism</a>, <script data-card-contents-for-ri="3855" type="text/json">{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4480" rel="nofollow" href="https://www.academia.edu/Documents/in/Population_Genetics">Population Genetics</a>, <script data-card-contents-for-ri="4480" type="text/json">{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27336" rel="nofollow" href="https://www.academia.edu/Documents/in/France">France</a><script data-card-contents-for-ri="27336" type="text/json">{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3442521]'), work: {"id":3442521,"title":"mtDNA polymorphisms in five French groups: importance of regional sampling","created_at":"2013-05-01T16:58:52.089-07:00","url":"https://www.academia.edu/3442521/mtDNA_polymorphisms_in_five_French_groups_importance_of_regional_sampling?f_ri=279027","dom_id":"work_3442521","summary":"According to classical markers, France has been reported to be regionally heterogeneous. Here, we propose to test the homogeneity of the French mitochondrial gene pool by analysing D-Loop and coding regions polymorphisms in 210 individuals stemming from five regions. The data set obtained was also used to test the ability of mitochondrial DNA to detect well historically established admixtures (admixtures between British/Irish people and native Breton people in our case). For these purposes, the sampling procedure was subject to special care, concerning the individuals' geographical origin and maternal pedigree. The mtDNA analysis revealed some regional specificities in haplogroup distribution, which is discussed in terms of successive settlements of France. Statistical analyses were conducted to investigate mtDNA diversity and structure within and between British, Irish and French groups. They tended to show affinities between Morbihan region and Britain plus Ireland. Furthermore, genetic evidences were in line with the fact that Morbihan region results from an admixture event, agreeing with historical evidences of successive migrations from Britain and Ireland into Brittany. These results also tended to outline the fact that two geographically very adjacent samples (Morbihan and Finistère), sharing a cultural and linguistic area, can present a distinct genetic pattern. Although mtDNA analyses were able to identify a historically reported admixture event, we point out here the high influence of the sampling procedure and representativeness over the migrations hypothesis. We also underline the importance of regional sampling for studies on the spread and/or origin of specific European haplogroups (here U5a1a and U8).","downloadable_attachments":[{"id":50279404,"asset_id":3442521,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4017914,"first_name":"Vincent","last_name":"Dubut","domain_name":"independent","page_name":"VincentDubut","display_name":"Vincent Dubut","profile_url":"https://independent.academia.edu/VincentDubut?f_ri=279027","photo":"https://0.academia-photos.com/4017914/1526481/1855064/s65_vincent.dubut.jpg"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=279027","nofollow":true},{"id":3855,"name":"Polymorphism","url":"https://www.academia.edu/Documents/in/Polymorphism?f_ri=279027","nofollow":true},{"id":4480,"name":"Population Genetics","url":"https://www.academia.edu/Documents/in/Population_Genetics?f_ri=279027","nofollow":true},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=279027","nofollow":true},{"id":63093,"name":"Mitochondrial DNA","url":"https://www.academia.edu/Documents/in/Mitochondrial_DNA?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_24488524 coauthored" data-work_id="24488524" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/24488524/Recommendations_for_participation_in_leisure_time_physical_activity_and_competitive_sports_in_patients_with_arrhythmias_and_potentially_arrhythmogenic_conditions_Part_I_Supraventricular_arrhythmias_and_pacemakers">Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions Part I: Supraventricular arrhythmias and pacemakers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This consensus paper on behalf of the Study Group on Sports Cardiology of the European Society of Cardiology follows a previous one on guidelines for sports participation in competitive and recreational athletes with supraventricular... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_24488524" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This consensus paper on behalf of the Study Group on Sports Cardiology of the European Society of Cardiology follows a previous one on guidelines for sports participation in competitive and recreational athletes with supraventricular arrhythmias and pacemakers. The question of imminent life-threatening arrhythmias is especially relevant when some form of ventricular rhythm disorder is documented, or when the patient is diagnosed to have inherited a pro-arrhythmogenic disorder. Frequent ventricular premature beats or nonsustained ventricular tachycardia may be a hallmark of underlying pathology and increased risk. Their finding should prompt a thorough cardiac evaluation, including both imaging modalities and electrophysiological techniques. This should allow distinguishing idiopathic rhythm disorders from underlying disease that carries a more ominous prognosis. Recommendations on sports participation in inherited arrhythmogenic conditions and asymptomatic gene carriers are also discussed: congenital and acquired long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy and other familial electrical disease of unknown origin. If an implantable cardioverter defibrillator is indicated, it is no substitute for the guidelines relating to the underlying pathology. Moreover, some particular recommendations for patients/ athletes with an implantable cardioverter defibrillator are to be observed. Eur J Cardiovasc Prev Rehabil 13:676-686</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/24488524" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="940418b96f2487c6eeebc3e0f349f98b" rel="nofollow" data-download="{"attachment_id":44821642,"asset_id":24488524,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44821642/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47198502" href="https://uva.academia.edu/NPanhuyzengoedkoop">N. Panhuyzen-goedkoop</a><script data-card-contents-for-user="47198502" type="text/json">{"id":47198502,"first_name":"N.","last_name":"Panhuyzen-goedkoop","domain_name":"uva","page_name":"NPanhuyzengoedkoop","display_name":"N. Panhuyzen-goedkoop","profile_url":"https://uva.academia.edu/NPanhuyzengoedkoop?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-24488524">+1</span><div class="hidden js-additional-users-24488524"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/ABiffi">Alessandro Biffi</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-24488524'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-24488524').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_24488524 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="24488524"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 24488524, container: ".js-paper-rank-work_24488524", }); });</script></li><li class="js-percentile-work_24488524 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 24488524; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_24488524"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_24488524 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="24488524"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24488524; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=24488524]").text(description); $(".js-view-count-work_24488524").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_24488524").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="24488524"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" rel="nofollow" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50456" rel="nofollow" href="https://www.academia.edu/Documents/in/Sports">Sports</a>, <script data-card-contents-for-ri="50456" type="text/json">{"id":50456,"name":"Sports","url":"https://www.academia.edu/Documents/in/Sports?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="130890" rel="nofollow" href="https://www.academia.edu/Documents/in/Atrial_Fibrillation">Atrial Fibrillation</a>, <script data-card-contents-for-ri="130890" type="text/json">{"id":130890,"name":"Atrial Fibrillation","url":"https://www.academia.edu/Documents/in/Atrial_Fibrillation?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="135185" rel="nofollow" href="https://www.academia.edu/Documents/in/Exercise">Exercise</a><script data-card-contents-for-ri="135185" type="text/json">{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=24488524]'), work: {"id":24488524,"title":"Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions Part I: Supraventricular arrhythmias and pacemakers","created_at":"2016-04-17T07:55:36.884-07:00","url":"https://www.academia.edu/24488524/Recommendations_for_participation_in_leisure_time_physical_activity_and_competitive_sports_in_patients_with_arrhythmias_and_potentially_arrhythmogenic_conditions_Part_I_Supraventricular_arrhythmias_and_pacemakers?f_ri=279027","dom_id":"work_24488524","summary":"This consensus paper on behalf of the Study Group on Sports Cardiology of the European Society of Cardiology follows a previous one on guidelines for sports participation in competitive and recreational athletes with supraventricular arrhythmias and pacemakers. The question of imminent life-threatening arrhythmias is especially relevant when some form of ventricular rhythm disorder is documented, or when the patient is diagnosed to have inherited a pro-arrhythmogenic disorder. Frequent ventricular premature beats or nonsustained ventricular tachycardia may be a hallmark of underlying pathology and increased risk. Their finding should prompt a thorough cardiac evaluation, including both imaging modalities and electrophysiological techniques. This should allow distinguishing idiopathic rhythm disorders from underlying disease that carries a more ominous prognosis. Recommendations on sports participation in inherited arrhythmogenic conditions and asymptomatic gene carriers are also discussed: congenital and acquired long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy and other familial electrical disease of unknown origin. If an implantable cardioverter defibrillator is indicated, it is no substitute for the guidelines relating to the underlying pathology. Moreover, some particular recommendations for patients/ athletes with an implantable cardioverter defibrillator are to be observed. Eur J Cardiovasc Prev Rehabil 13:676-686","downloadable_attachments":[{"id":44821642,"asset_id":24488524,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47198502,"first_name":"N.","last_name":"Panhuyzen-goedkoop","domain_name":"uva","page_name":"NPanhuyzengoedkoop","display_name":"N. Panhuyzen-goedkoop","profile_url":"https://uva.academia.edu/NPanhuyzengoedkoop?f_ri=279027","photo":"/images/s65_no_pic.png"},{"id":48413880,"first_name":"Alessandro","last_name":"Biffi","domain_name":"independent","page_name":"ABiffi","display_name":"Alessandro Biffi","profile_url":"https://independent.academia.edu/ABiffi?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=279027","nofollow":true},{"id":50456,"name":"Sports","url":"https://www.academia.edu/Documents/in/Sports?f_ri=279027","nofollow":true},{"id":130890,"name":"Atrial Fibrillation","url":"https://www.academia.edu/Documents/in/Atrial_Fibrillation?f_ri=279027","nofollow":true},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":323090,"name":"Cardiac Arrhythmias","url":"https://www.academia.edu/Documents/in/Cardiac_Arrhythmias?f_ri=279027"},{"id":746681,"name":"Arrhythmia","url":"https://www.academia.edu/Documents/in/Arrhythmia?f_ri=279027"},{"id":751399,"name":"Atrial Flutter","url":"https://www.academia.edu/Documents/in/Atrial_Flutter?f_ri=279027"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=279027"},{"id":1795787,"name":"Leisure Activities","url":"https://www.academia.edu/Documents/in/Leisure_Activities?f_ri=279027"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67214461" data-work_id="67214461" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67214461/The_development_and_evaluation_of_a_program_to_sensitize_Greek_Grammar_School_Students_to_issues_relating_to_disability">The development and evaluation of a program to sensitize Greek Grammar School Students to issues relating to disability</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">This paper describes the design (process and content), implementation, and evaluation of a program module developed to sensitize elementary school students to issues related to disability. The objectives of the activities were to enable... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67214461" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This paper describes the design (process and content), implementation, and evaluation of a program module developed to sensitize elementary school students to issues related to disability. The objectives of the activities were to enable the students to gain factual and practical information about people with disabilities and the barriers (physical, psychological, social-emotional) they encounter. Another objective of the program was to help students and teachers examine their own attitudes toward disabilities, their stereotypes, and rejection mechanisms and stigmatization tendencies. The program evaluation outcomes suggest that students were sensitized to issues related to disability and reported more positive attitudes toward their disabled counterparts.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67214461" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="32d9eddca69985ab7568c10142cb59b7" rel="nofollow" data-download="{"attachment_id":78115586,"asset_id":67214461,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78115586/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="966238" href="https://crete.academia.edu/SofiaTriliva">Sofia Triliva</a><script data-card-contents-for-user="966238" type="text/json">{"id":966238,"first_name":"Sofia","last_name":"Triliva","domain_name":"crete","page_name":"SofiaTriliva","display_name":"Sofia Triliva","profile_url":"https://crete.academia.edu/SofiaTriliva?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67214461 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67214461"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67214461, container: ".js-paper-rank-work_67214461", }); });</script></li><li class="js-percentile-work_67214461 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67214461; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_67214461"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_67214461 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="67214461"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67214461; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67214461]").text(description); $(".js-view-count-work_67214461").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67214461").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67214461"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="129913" rel="nofollow" href="https://www.academia.edu/Documents/in/Attitudes">Attitudes</a>, <script data-card-contents-for-ri="129913" type="text/json">{"id":129913,"name":"Attitudes","url":"https://www.academia.edu/Documents/in/Attitudes?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67214461]'), work: {"id":67214461,"title":"The development and evaluation of a program to sensitize Greek Grammar School Students to issues relating to disability","created_at":"2022-01-05T04:36:35.593-08:00","url":"https://www.academia.edu/67214461/The_development_and_evaluation_of_a_program_to_sensitize_Greek_Grammar_School_Students_to_issues_relating_to_disability?f_ri=279027","dom_id":"work_67214461","summary":"This paper describes the design (process and content), implementation, and evaluation of a program module developed to sensitize elementary school students to issues related to disability. The objectives of the activities were to enable the students to gain factual and practical information about people with disabilities and the barriers (physical, psychological, social-emotional) they encounter. Another objective of the program was to help students and teachers examine their own attitudes toward disabilities, their stereotypes, and rejection mechanisms and stigmatization tendencies. The program evaluation outcomes suggest that students were sensitized to issues related to disability and reported more positive attitudes toward their disabled counterparts.","downloadable_attachments":[{"id":78115586,"asset_id":67214461,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":966238,"first_name":"Sofia","last_name":"Triliva","domain_name":"crete","page_name":"SofiaTriliva","display_name":"Sofia Triliva","profile_url":"https://crete.academia.edu/SofiaTriliva?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=279027","nofollow":true},{"id":129913,"name":"Attitudes","url":"https://www.academia.edu/Documents/in/Attitudes?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25716688" data-work_id="25716688" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25716688/Adult_demography_dispersal_and_behaviour_of_Brenthis_ino_Lepidoptera_Nymphalidae_how_to_be_a_successful_wetland_butterfly">Adult demography, dispersal and behaviour of Brenthis ino (Lepidoptera: Nymphalidae): how to be a successful wetland butterfly</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Nymphalidae): how to be a successful wetland butterfly Abstract. Continent-wide loss of traditionally managed humid meadows is raising concern for associated butterfly specialists across Europe. However, not all species associated with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_25716688" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Nymphalidae): how to be a successful wetland butterfly Abstract. Continent-wide loss of traditionally managed humid meadows is raising concern for associated butterfly specialists across Europe. However, not all species associated with this biotope are threatened, and the Lesser Marbled Fritillary (Brenthis ino) has even spread locally. We employed mark-recapture and transect walks to study its population structure and patterns of landscape occupancy in a hilly region of western Bohemia, Central Europe, to determine which life history or demography traits might be responsible for its success. A population studied by mark-recapture harboured more than 1000 individuals and was interconnected with other populations. This was further supported by a fit of the inverse power function to dispersal data. Observations of adult behaviour revealed a broad host plant range: at least three species of plants were used by the single population. On a landscape scale, the butterfly exhibited an aggregated distribution matching its host plants. It was associated with the distribution of characteristic plants and butterflies of semi-natural humid meadows, but its frequency exceeded those of other humid grasslands specialists. The relatively broad host range coupled with varying biotope requirements of individual host plant species results in a wide biotope range for the butterfly, explaining its persistence in fragmented Central European landscapes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25716688" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="268fd1a4496ff30057b902b34a293707" rel="nofollow" data-download="{"attachment_id":46064054,"asset_id":25716688,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46064054/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2183674" href="https://cas-cz.academia.edu/ZdenekFaltynekFric">Zdenek Faltynek Fric</a><script data-card-contents-for-user="2183674" type="text/json">{"id":2183674,"first_name":"Zdenek","last_name":"Faltynek Fric","domain_name":"cas-cz","page_name":"ZdenekFaltynekFric","display_name":"Zdenek Faltynek Fric","profile_url":"https://cas-cz.academia.edu/ZdenekFaltynekFric?f_ri=279027","photo":"https://0.academia-photos.com/2183674/702013/871875/s65_zdenek.faltynek_fric.jpg"}</script></span></span></li><li class="js-paper-rank-work_25716688 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25716688"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 25716688, container: ".js-paper-rank-work_25716688", }); });</script></li><li class="js-percentile-work_25716688 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 25716688; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_25716688"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_25716688 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="25716688"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 25716688; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=25716688]").text(description); $(".js-view-count-work_25716688").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_25716688").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="25716688"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="173" rel="nofollow" href="https://www.academia.edu/Documents/in/Zoology">Zoology</a>, <script data-card-contents-for-ri="173" type="text/json">{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25716688]'), work: {"id":25716688,"title":"Adult demography, dispersal and behaviour of Brenthis ino (Lepidoptera: Nymphalidae): how to be a successful wetland butterfly","created_at":"2016-05-30T02:21:38.356-07:00","url":"https://www.academia.edu/25716688/Adult_demography_dispersal_and_behaviour_of_Brenthis_ino_Lepidoptera_Nymphalidae_how_to_be_a_successful_wetland_butterfly?f_ri=279027","dom_id":"work_25716688","summary":"Nymphalidae): how to be a successful wetland butterfly Abstract. Continent-wide loss of traditionally managed humid meadows is raising concern for associated butterfly specialists across Europe. However, not all species associated with this biotope are threatened, and the Lesser Marbled Fritillary (Brenthis ino) has even spread locally. We employed mark-recapture and transect walks to study its population structure and patterns of landscape occupancy in a hilly region of western Bohemia, Central Europe, to determine which life history or demography traits might be responsible for its success. A population studied by mark-recapture harboured more than 1000 individuals and was interconnected with other populations. This was further supported by a fit of the inverse power function to dispersal data. Observations of adult behaviour revealed a broad host plant range: at least three species of plants were used by the single population. On a landscape scale, the butterfly exhibited an aggregated distribution matching its host plants. It was associated with the distribution of characteristic plants and butterflies of semi-natural humid meadows, but its frequency exceeded those of other humid grasslands specialists. The relatively broad host range coupled with varying biotope requirements of individual host plant species results in a wide biotope range for the butterfly, explaining its persistence in fragmented Central European landscapes.","downloadable_attachments":[{"id":46064054,"asset_id":25716688,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":2183674,"first_name":"Zdenek","last_name":"Faltynek Fric","domain_name":"cas-cz","page_name":"ZdenekFaltynekFric","display_name":"Zdenek Faltynek Fric","profile_url":"https://cas-cz.academia.edu/ZdenekFaltynekFric?f_ri=279027","photo":"https://0.academia-photos.com/2183674/702013/871875/s65_zdenek.faltynek_fric.jpg"}],"research_interests":[{"id":173,"name":"Zoology","url":"https://www.academia.edu/Documents/in/Zoology?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13738316" data-work_id="13738316" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13738316/Drug_permeation_in_biomembranes_in_vitro_and_in_silico_prediction_and_influence_of_physicochemical_properties">Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">In the past decades, it has become increasingly apparent that in addition to therapeutic effect, drugs need to exhibit favourable absorption, distribution, metabolism and excretion (ADME) characteristics to produce a desirable response in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13738316" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">In the past decades, it has become increasingly apparent that in addition to therapeutic effect, drugs need to exhibit favourable absorption, distribution, metabolism and excretion (ADME) characteristics to produce a desirable response in vivo. As the recent progress in drug discovery technology enables rapid synthesis of vast numbers of potential drug candidates, robust methods are required for the effective screening of compounds synthesized within such programs, so that compounds with poor pharmacokinetic properties can be rejected at an early stage of drug development. Furthermore, a viable in silico method would save resources by enabling virtual screening of drug candidates already prior to synthesis. This review gives a general overview of the approaches aimed at predicting biological permeation, one of the cornerstones behind the ADME behaviour of drugs. The most important experimental and computational models are reviewed. Physicochemical factors underlying the permeation process are discussed.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13738316" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2be1ca29bca56378d65edec048a9ea4e" rel="nofollow" data-download="{"attachment_id":38834178,"asset_id":13738316,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38834178/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32859969" href="https://aalto-fi.academia.edu/LasseMurtomaki">Lasse Murtomaki</a><script data-card-contents-for-user="32859969" type="text/json">{"id":32859969,"first_name":"Lasse","last_name":"Murtomaki","domain_name":"aalto-fi","page_name":"LasseMurtomaki","display_name":"Lasse Murtomaki","profile_url":"https://aalto-fi.academia.edu/LasseMurtomaki?f_ri=279027","photo":"https://0.academia-photos.com/32859969/20214864/19940125/s65_lasse.murtomaki.jpg"}</script></span></span></li><li class="js-paper-rank-work_13738316 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13738316"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13738316, container: ".js-paper-rank-work_13738316", }); });</script></li><li class="js-percentile-work_13738316 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13738316; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13738316"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13738316 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13738316"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13738316; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13738316]").text(description); $(".js-view-count-work_13738316").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13738316").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13738316"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="428" rel="nofollow" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="532" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Chemistry">Physical Chemistry</a>, <script data-card-contents-for-ri="532" type="text/json">{"id":532,"name":"Physical Chemistry","url":"https://www.academia.edu/Documents/in/Physical_Chemistry?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4377" rel="nofollow" href="https://www.academia.edu/Documents/in/Membranes">Membranes</a>, <script data-card-contents-for-ri="4377" type="text/json">{"id":4377,"name":"Membranes","url":"https://www.academia.edu/Documents/in/Membranes?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7968" rel="nofollow" href="https://www.academia.edu/Documents/in/Prediction">Prediction</a><script data-card-contents-for-ri="7968" type="text/json">{"id":7968,"name":"Prediction","url":"https://www.academia.edu/Documents/in/Prediction?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13738316]'), work: {"id":13738316,"title":"Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties","created_at":"2015-07-07T01:17:55.806-07:00","url":"https://www.academia.edu/13738316/Drug_permeation_in_biomembranes_in_vitro_and_in_silico_prediction_and_influence_of_physicochemical_properties?f_ri=279027","dom_id":"work_13738316","summary":"In the past decades, it has become increasingly apparent that in addition to therapeutic effect, drugs need to exhibit favourable absorption, distribution, metabolism and excretion (ADME) characteristics to produce a desirable response in vivo. As the recent progress in drug discovery technology enables rapid synthesis of vast numbers of potential drug candidates, robust methods are required for the effective screening of compounds synthesized within such programs, so that compounds with poor pharmacokinetic properties can be rejected at an early stage of drug development. Furthermore, a viable in silico method would save resources by enabling virtual screening of drug candidates already prior to synthesis. This review gives a general overview of the approaches aimed at predicting biological permeation, one of the cornerstones behind the ADME behaviour of drugs. The most important experimental and computational models are reviewed. Physicochemical factors underlying the permeation process are discussed.","downloadable_attachments":[{"id":38834178,"asset_id":13738316,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32859969,"first_name":"Lasse","last_name":"Murtomaki","domain_name":"aalto-fi","page_name":"LasseMurtomaki","display_name":"Lasse Murtomaki","profile_url":"https://aalto-fi.academia.edu/LasseMurtomaki?f_ri=279027","photo":"https://0.academia-photos.com/32859969/20214864/19940125/s65_lasse.murtomaki.jpg"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=279027","nofollow":true},{"id":532,"name":"Physical Chemistry","url":"https://www.academia.edu/Documents/in/Physical_Chemistry?f_ri=279027","nofollow":true},{"id":4377,"name":"Membranes","url":"https://www.academia.edu/Documents/in/Membranes?f_ri=279027","nofollow":true},{"id":7968,"name":"Prediction","url":"https://www.academia.edu/Documents/in/Prediction?f_ri=279027","nofollow":true},{"id":11111,"name":"Pharmacokinetics","url":"https://www.academia.edu/Documents/in/Pharmacokinetics?f_ri=279027"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro?f_ri=279027"},{"id":69542,"name":"Computer Simulation","url":"https://www.academia.edu/Documents/in/Computer_Simulation?f_ri=279027"},{"id":83972,"name":"Permeability","url":"https://www.academia.edu/Documents/in/Permeability?f_ri=279027"},{"id":84249,"name":"Computational Models","url":"https://www.academia.edu/Documents/in/Computational_Models?f_ri=279027"},{"id":121823,"name":"Biomembrane","url":"https://www.academia.edu/Documents/in/Biomembrane?f_ri=279027"},{"id":135503,"name":"Partition","url":"https://www.academia.edu/Documents/in/Partition?f_ri=279027"},{"id":162983,"name":"Absorption","url":"https://www.academia.edu/Documents/in/Absorption?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":2380004,"name":"Pharmaceutical preparations","url":"https://www.academia.edu/Documents/in/Pharmaceutical_preparations?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18439979" data-work_id="18439979" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18439979/Do_angle_stable_implants_provide_advantages_Treatment_of_distal_radius_fractures_with_the_locking_compression_plate_LCP_">Do angle stable implants provide advantages? Treatment of distal radius fractures with the locking compression plate (LCP)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Can distal radius fractures be held in place with palmar locking compression plates (LCPs) and heal completely without an additional bone transplant? From 1 March 2001 to 1 September 2002, 40 patients with distal radius fractures (CCF: 2·... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18439979" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Can distal radius fractures be held in place with palmar locking compression plates (LCPs) and heal completely without an additional bone transplant? From 1 March 2001 to 1 September 2002, 40 patients with distal radius fractures (CCF: 2· A2, 13· A3, 2· C1, 22· C2 and 1· C3 fractures) were treated with locking compression small fragment titanium plates. In 37 cases, the plates were inserted in a palmar direction without an additional corticocancellous bone graft. All patients received a follow-up check-up after an average of 12.1 months. On this occasion, the range of motion, grip strength and radiological result were measured and rated according to the Gartland and DASH score. All fractures healed completely. In one case, a re-osteosynthesis was carried out after the plate had bent because full load was placed on it prematurely. An average of 5.1 points was achieved in the Gartland and 12.6 points in the DASH score. An extremely good result was achieved in 19 cases, a good result in 15 and a satisfactory result in 6. At the follow-up examination, the average range of motion was 52°-0°-50°f or stretching and bending in the wrist, 20°-0°-27°for radial and ulnar deviation and 82°-0°-78°for pronation and supination. On the radiographs, the average radiocarpal angle in the anteroposterior projection was 22°w ith a palmar tilt of an average of 5°. Radius fractures with metaphyseal, one-sided comminuted zones can be treated with locking compression plates with good results using a palmar approach without a cancellous bone graft.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18439979" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="37847fb5e2705c0523998a79f5f1f840" rel="nofollow" data-download="{"attachment_id":40064734,"asset_id":18439979,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40064734/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38447915" href="https://independent.academia.edu/JAndermahr">J. Andermahr</a><script data-card-contents-for-user="38447915" type="text/json">{"id":38447915,"first_name":"J.","last_name":"Andermahr","domain_name":"independent","page_name":"JAndermahr","display_name":"J. Andermahr","profile_url":"https://independent.academia.edu/JAndermahr?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18439979 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18439979"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18439979, container: ".js-paper-rank-work_18439979", }); });</script></li><li class="js-percentile-work_18439979 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 18439979; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_18439979"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_18439979 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="18439979"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 18439979; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=18439979]").text(description); $(".js-view-count-work_18439979").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18439979").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18439979"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18439979]'), work: {"id":18439979,"title":"Do angle stable implants provide advantages? Treatment of distal radius fractures with the locking compression plate (LCP)","created_at":"2015-11-16T06:14:40.634-08:00","url":"https://www.academia.edu/18439979/Do_angle_stable_implants_provide_advantages_Treatment_of_distal_radius_fractures_with_the_locking_compression_plate_LCP_?f_ri=279027","dom_id":"work_18439979","summary":"Can distal radius fractures be held in place with palmar locking compression plates (LCPs) and heal completely without an additional bone transplant? From 1 March 2001 to 1 September 2002, 40 patients with distal radius fractures (CCF: 2· A2, 13· A3, 2· C1, 22· C2 and 1· C3 fractures) were treated with locking compression small fragment titanium plates. In 37 cases, the plates were inserted in a palmar direction without an additional corticocancellous bone graft. All patients received a follow-up check-up after an average of 12.1 months. On this occasion, the range of motion, grip strength and radiological result were measured and rated according to the Gartland and DASH score. All fractures healed completely. In one case, a re-osteosynthesis was carried out after the plate had bent because full load was placed on it prematurely. An average of 5.1 points was achieved in the Gartland and 12.6 points in the DASH score. An extremely good result was achieved in 19 cases, a good result in 15 and a satisfactory result in 6. At the follow-up examination, the average range of motion was 52°-0°-50°f or stretching and bending in the wrist, 20°-0°-27°for radial and ulnar deviation and 82°-0°-78°for pronation and supination. On the radiographs, the average radiocarpal angle in the anteroposterior projection was 22°w ith a palmar tilt of an average of 5°. Radius fractures with metaphyseal, one-sided comminuted zones can be treated with locking compression plates with good results using a palmar approach without a cancellous bone graft.","downloadable_attachments":[{"id":40064734,"asset_id":18439979,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38447915,"first_name":"J.","last_name":"Andermahr","domain_name":"independent","page_name":"JAndermahr","display_name":"J. Andermahr","profile_url":"https://independent.academia.edu/JAndermahr?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33155318" data-work_id="33155318" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33155318/Lifestyle_and_indoor_air_pollution_allergens">Lifestyle and indoor air pollution: allergens</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Indoor allergens have been implicated in both increasing asthma prevalence and severity. In this chapter the following are reviewed: 1) common indoor allergens, their origins and methods of assessing and quantifying exposure to them; 2)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33155318" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Indoor allergens have been implicated in both increasing asthma prevalence and severity. In this chapter the following are reviewed: 1) common indoor allergens, their origins and methods of assessing and quantifying exposure to them; 2) evidence for the role of allergens in the aetiology of both sensitisation and asthma; 3) the role of allergens in increasing the severity of asthma; and 4) the effect of reduction in allergen exposure on prevention of asthma development and control of symptoms in established disease.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33155318" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eb28f651d4d031e7af6c4ae83274e7f8" rel="nofollow" data-download="{"attachment_id":53243327,"asset_id":33155318,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53243327/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64535591" href="https://independent.academia.edu/CustovicAdnan">Adnan Custovic</a><script data-card-contents-for-user="64535591" type="text/json">{"id":64535591,"first_name":"Adnan","last_name":"Custovic","domain_name":"independent","page_name":"CustovicAdnan","display_name":"Adnan Custovic","profile_url":"https://independent.academia.edu/CustovicAdnan?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_33155318 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33155318"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33155318, container: ".js-paper-rank-work_33155318", }); });</script></li><li class="js-percentile-work_33155318 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33155318; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33155318"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33155318 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33155318"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33155318; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33155318]").text(description); $(".js-view-count-work_33155318").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33155318").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33155318"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33155318]'), work: {"id":33155318,"title":"Lifestyle and indoor air pollution: allergens","created_at":"2017-05-23T02:02:36.518-07:00","url":"https://www.academia.edu/33155318/Lifestyle_and_indoor_air_pollution_allergens?f_ri=279027","dom_id":"work_33155318","summary":"Indoor allergens have been implicated in both increasing asthma prevalence and severity. In this chapter the following are reviewed: 1) common indoor allergens, their origins and methods of assessing and quantifying exposure to them; 2) evidence for the role of allergens in the aetiology of both sensitisation and asthma; 3) the role of allergens in increasing the severity of asthma; and 4) the effect of reduction in allergen exposure on prevention of asthma development and control of symptoms in established disease.","downloadable_attachments":[{"id":53243327,"asset_id":33155318,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64535591,"first_name":"Adnan","last_name":"Custovic","domain_name":"independent","page_name":"CustovicAdnan","display_name":"Adnan Custovic","profile_url":"https://independent.academia.edu/CustovicAdnan?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13546921" data-work_id="13546921" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13546921/Predictors_of_violence_in_young_tourists_a_comparative_study_of_British_German_and_Spanish_holidaymakers">Predictors of violence in young tourists: a comparative study of British, German and Spanish holidaymakers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: International youth holiday resorts feature many of the key risk factors for violence, including large numbers of bars and nightclubs and high levels of substance use. However, little information currently exists on the extent... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13546921" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: International youth holiday resorts feature many of the key risk factors for violence, including large numbers of bars and nightclubs and high levels of substance use. However, little information currently exists on the extent of violence amongst holidaymakers or factors that increase risks of involvement in fights on holiday. Methods: A cross-sectional comparative survey of 3003 British, German and Spanish holidaymakers aged 16-35 years, undertaken in the departure areas of Ibiza and Majorca (Spain) airports. Results: Nightlife was the most common reason for destination choice in both locations. Overall, more than half of participants reported drinking to drunkenness at least 2 days per week during their holiday (59.3% Majorca, 58.0% Ibiza; significantly lower in Spanish participants in both locations). Levels of illicit drug use were highest in Ibiza and in British and Spanish holidaymakers. Levels of violence were highest in Majorca, where 6.4% of participants reported involvement in a fight, compared with 2.8% in Ibiza. However, after controlling for confounding factors, holiday destination was not a significant predictor of violence. Predictors of fighting were being male, young, British, frequent drunkenness and use of cannabis or cocaine during the holiday. Use of ecstasy on holiday was associated with not being involved in violence. Conclusions: High levels of substance use contribute to violence being a relatively common feature of young people's visits to international holiday resorts. To protect the health and well-being of holidaymakers and local populations in popular resorts, violence and substance use prevention must adapt to an increasingly globalized nightlife.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13546921" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a00bb0afbb817981b328d0f53d35cde7" rel="nofollow" data-download="{"attachment_id":45224208,"asset_id":13546921,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45224208/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32736960" href="https://independent.academia.edu/AmadorCalafat">Amador Calafat</a><script data-card-contents-for-user="32736960" type="text/json">{"id":32736960,"first_name":"Amador","last_name":"Calafat","domain_name":"independent","page_name":"AmadorCalafat","display_name":"Amador Calafat","profile_url":"https://independent.academia.edu/AmadorCalafat?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13546921 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13546921"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13546921, container: ".js-paper-rank-work_13546921", }); });</script></li><li class="js-percentile-work_13546921 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13546921; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_13546921"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_13546921 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="13546921"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13546921; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13546921]").text(description); $(".js-view-count-work_13546921").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13546921").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13546921"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1697" rel="nofollow" href="https://www.academia.edu/Documents/in/Violence">Violence</a>, <script data-card-contents-for-ri="1697" type="text/json">{"id":1697,"name":"Violence","url":"https://www.academia.edu/Documents/in/Violence?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="16288" rel="nofollow" href="https://www.academia.edu/Documents/in/Public_Health">Public Health</a>, <script data-card-contents-for-ri="16288" type="text/json">{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33666" rel="nofollow" href="https://www.academia.edu/Documents/in/European_Public_Health_Policies">European Public Health Policies</a><script data-card-contents-for-ri="33666" type="text/json">{"id":33666,"name":"European Public Health Policies","url":"https://www.academia.edu/Documents/in/European_Public_Health_Policies?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13546921]'), work: {"id":13546921,"title":"Predictors of violence in young tourists: a comparative study of British, German and Spanish holidaymakers","created_at":"2015-07-02T08:31:43.909-07:00","url":"https://www.academia.edu/13546921/Predictors_of_violence_in_young_tourists_a_comparative_study_of_British_German_and_Spanish_holidaymakers?f_ri=279027","dom_id":"work_13546921","summary":"Background: International youth holiday resorts feature many of the key risk factors for violence, including large numbers of bars and nightclubs and high levels of substance use. However, little information currently exists on the extent of violence amongst holidaymakers or factors that increase risks of involvement in fights on holiday. Methods: A cross-sectional comparative survey of 3003 British, German and Spanish holidaymakers aged 16-35 years, undertaken in the departure areas of Ibiza and Majorca (Spain) airports. Results: Nightlife was the most common reason for destination choice in both locations. Overall, more than half of participants reported drinking to drunkenness at least 2 days per week during their holiday (59.3% Majorca, 58.0% Ibiza; significantly lower in Spanish participants in both locations). Levels of illicit drug use were highest in Ibiza and in British and Spanish holidaymakers. Levels of violence were highest in Majorca, where 6.4% of participants reported involvement in a fight, compared with 2.8% in Ibiza. However, after controlling for confounding factors, holiday destination was not a significant predictor of violence. Predictors of fighting were being male, young, British, frequent drunkenness and use of cannabis or cocaine during the holiday. Use of ecstasy on holiday was associated with not being involved in violence. Conclusions: High levels of substance use contribute to violence being a relatively common feature of young people's visits to international holiday resorts. To protect the health and well-being of holidaymakers and local populations in popular resorts, violence and substance use prevention must adapt to an increasingly globalized nightlife.","downloadable_attachments":[{"id":45224208,"asset_id":13546921,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32736960,"first_name":"Amador","last_name":"Calafat","domain_name":"independent","page_name":"AmadorCalafat","display_name":"Amador Calafat","profile_url":"https://independent.academia.edu/AmadorCalafat?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1697,"name":"Violence","url":"https://www.academia.edu/Documents/in/Violence?f_ri=279027","nofollow":true},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health?f_ri=279027","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true},{"id":33666,"name":"European Public Health Policies","url":"https://www.academia.edu/Documents/in/European_Public_Health_Policies?f_ri=279027","nofollow":true},{"id":40516,"name":"Spain","url":"https://www.academia.edu/Documents/in/Spain?f_ri=279027"},{"id":50576,"name":"Germany","url":"https://www.academia.edu/Documents/in/Germany?f_ri=279027"},{"id":57928,"name":"Travel","url":"https://www.academia.edu/Documents/in/Travel?f_ri=279027"},{"id":72353,"name":"Substance Use","url":"https://www.academia.edu/Documents/in/Substance_Use?f_ri=279027"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=279027"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=279027"},{"id":227342,"name":"Alcohol Consumption","url":"https://www.academia.edu/Documents/in/Alcohol_Consumption?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":291274,"name":"Great Britain","url":"https://www.academia.edu/Documents/in/Great_Britain?f_ri=279027"},{"id":404000,"name":"Cross Section","url":"https://www.academia.edu/Documents/in/Cross_Section?f_ri=279027"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=279027"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=279027"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=279027"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=279027"},{"id":999544,"name":"Illicit Drug Use","url":"https://www.academia.edu/Documents/in/Illicit_Drug_Use?f_ri=279027"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=279027"},{"id":1423077,"name":"Substance-Related Disorders","url":"https://www.academia.edu/Documents/in/Substance-Related_Disorders?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_31174828" data-work_id="31174828" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/31174828/Dialysis_and_Contrast_Media">Dialysis and Contrast Media</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/31174828" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="340b6accfacc8e5e8806eaa4e76b66da" rel="nofollow" data-download="{"attachment_id":51602465,"asset_id":31174828,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/51602465/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="46348053" href="https://independent.academia.edu/SamehMorcos">Sameh Morcos</a><script data-card-contents-for-user="46348053" type="text/json">{"id":46348053,"first_name":"Sameh","last_name":"Morcos","domain_name":"independent","page_name":"SamehMorcos","display_name":"Sameh Morcos","profile_url":"https://independent.academia.edu/SamehMorcos?f_ri=279027","photo":"https://0.academia-photos.com/46348053/12681458/14106079/s65_sameh.morcos.jpg_oh_7fbb7fa0da498280df9fedcc8a2b3834_oe_57e3da7f"}</script></span></span></li><li class="js-paper-rank-work_31174828 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="31174828"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 31174828, container: ".js-paper-rank-work_31174828", }); });</script></li><li class="js-percentile-work_31174828 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31174828; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_31174828"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_31174828 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="31174828"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31174828; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31174828]").text(description); $(".js-view-count-work_31174828").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_31174828").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="31174828"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9000" rel="nofollow" href="https://www.academia.edu/Documents/in/Acute_kidney_injury">Acute kidney injury</a>, <script data-card-contents-for-ri="9000" type="text/json">{"id":9000,"name":"Acute kidney injury","url":"https://www.academia.edu/Documents/in/Acute_kidney_injury?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="101212" rel="nofollow" href="https://www.academia.edu/Documents/in/Hemodialysis">Hemodialysis</a>, <script data-card-contents-for-ri="101212" type="text/json">{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="102488" rel="nofollow" href="https://www.academia.edu/Documents/in/Renal_failure">Renal failure</a>, <script data-card-contents-for-ri="102488" type="text/json">{"id":102488,"name":"Renal failure","url":"https://www.academia.edu/Documents/in/Renal_failure?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a><script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=31174828]'), work: {"id":31174828,"title":"Dialysis and Contrast Media","created_at":"2017-02-02T08:01:56.289-08:00","url":"https://www.academia.edu/31174828/Dialysis_and_Contrast_Media?f_ri=279027","dom_id":"work_31174828","summary":null,"downloadable_attachments":[{"id":51602465,"asset_id":31174828,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":46348053,"first_name":"Sameh","last_name":"Morcos","domain_name":"independent","page_name":"SamehMorcos","display_name":"Sameh Morcos","profile_url":"https://independent.academia.edu/SamehMorcos?f_ri=279027","photo":"https://0.academia-photos.com/46348053/12681458/14106079/s65_sameh.morcos.jpg_oh_7fbb7fa0da498280df9fedcc8a2b3834_oe_57e3da7f"}],"research_interests":[{"id":9000,"name":"Acute kidney injury","url":"https://www.academia.edu/Documents/in/Acute_kidney_injury?f_ri=279027","nofollow":true},{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis?f_ri=279027","nofollow":true},{"id":102488,"name":"Renal failure","url":"https://www.academia.edu/Documents/in/Renal_failure?f_ri=279027","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=279027","nofollow":true},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=279027"},{"id":227354,"name":"Renal Function","url":"https://www.academia.edu/Documents/in/Renal_Function?f_ri=279027"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":447741,"name":"Peritoneal Dialysis","url":"https://www.academia.edu/Documents/in/Peritoneal_Dialysis?f_ri=279027"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=279027"},{"id":898062,"name":"Flow Rate","url":"https://www.academia.edu/Documents/in/Flow_Rate?f_ri=279027"},{"id":1010725,"name":"Protein Binding","url":"https://www.academia.edu/Documents/in/Protein_Binding?f_ri=279027"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=279027"},{"id":1407305,"name":"Contrast Media","url":"https://www.academia.edu/Documents/in/Contrast_Media?f_ri=279027"},{"id":1611680,"name":"Renal Dialysis","url":"https://www.academia.edu/Documents/in/Renal_Dialysis?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73633762" data-work_id="73633762" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73633762/Ethanol_alone_or_with_dexamethasone_alters_the_kinetics_of_choline_acetyltransferase">Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73633762" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further decreased by simultaneous injection of dexamethasone. Kinetic studies of cortex choline acetyltransferase activity in rats that had received 5 daily injections of ethanol or ethanol and dexamethasone indicated that the observed reduction in enzyme activity was due to an apparent reduction in affinity (K,,) of the enzyme for acetyl coenzyme A with no significant change in the total amount of enzyme present (V,,,,). This finding has implications with respect to the use of choline acetyltransferase as a marker for cholinergic neurons, and for the understanding of the regulation of choline acetyltransferase activity in the brain.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73633762" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9a1fd61dd5af2255c1c3a0935788f346" rel="nofollow" data-download="{"attachment_id":83858509,"asset_id":73633762,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83858509/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="6127817" href="https://independent.academia.edu/NaiphinichKotchabhakdi">Naiphinich Kotchabhakdi</a><script data-card-contents-for-user="6127817" type="text/json">{"id":6127817,"first_name":"Naiphinich","last_name":"Kotchabhakdi","domain_name":"independent","page_name":"NaiphinichKotchabhakdi","display_name":"Naiphinich Kotchabhakdi","profile_url":"https://independent.academia.edu/NaiphinichKotchabhakdi?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73633762 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73633762"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73633762, container: ".js-paper-rank-work_73633762", }); });</script></li><li class="js-percentile-work_73633762 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73633762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73633762"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73633762 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73633762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73633762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73633762]").text(description); $(".js-view-count-work_73633762").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73633762").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73633762"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4987" rel="nofollow" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57556" rel="nofollow" href="https://www.academia.edu/Documents/in/Hippocampus">Hippocampus</a>, <script data-card-contents-for-ri="57556" type="text/json">{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="57801" rel="nofollow" href="https://www.academia.edu/Documents/in/Dexamethasone">Dexamethasone</a>, <script data-card-contents-for-ri="57801" type="text/json">{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="78467" rel="nofollow" href="https://www.academia.edu/Documents/in/Cerebral_Cortex">Cerebral Cortex</a><script data-card-contents-for-ri="78467" type="text/json">{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73633762]'), work: {"id":73633762,"title":"Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase","created_at":"2022-03-12T20:31:24.699-08:00","url":"https://www.academia.edu/73633762/Ethanol_alone_or_with_dexamethasone_alters_the_kinetics_of_choline_acetyltransferase?f_ri=279027","dom_id":"work_73633762","summary":"activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further decreased by simultaneous injection of dexamethasone. Kinetic studies of cortex choline acetyltransferase activity in rats that had received 5 daily injections of ethanol or ethanol and dexamethasone indicated that the observed reduction in enzyme activity was due to an apparent reduction in affinity (K,,) of the enzyme for acetyl coenzyme A with no significant change in the total amount of enzyme present (V,,,,). This finding has implications with respect to the use of choline acetyltransferase as a marker for cholinergic neurons, and for the understanding of the regulation of choline acetyltransferase activity in the brain.","downloadable_attachments":[{"id":83858509,"asset_id":73633762,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6127817,"first_name":"Naiphinich","last_name":"Kotchabhakdi","domain_name":"independent","page_name":"NaiphinichKotchabhakdi","display_name":"Naiphinich Kotchabhakdi","profile_url":"https://independent.academia.edu/NaiphinichKotchabhakdi?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=279027","nofollow":true},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus?f_ri=279027","nofollow":true},{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone?f_ri=279027","nofollow":true},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=279027","nofollow":true},{"id":121705,"name":"Ethanol","url":"https://www.academia.edu/Documents/in/Ethanol?f_ri=279027"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=279027"},{"id":583568,"name":"Enzyme activity","url":"https://www.academia.edu/Documents/in/Enzyme_activity?f_ri=279027"},{"id":1293308,"name":"Glucocorticoids","url":"https://www.academia.edu/Documents/in/Glucocorticoids?f_ri=279027"},{"id":2058443,"name":"Choline Acetyltransferase","url":"https://www.academia.edu/Documents/in/Choline_Acetyltransferase?f_ri=279027"},{"id":2486335,"name":"Corpus striatum","url":"https://www.academia.edu/Documents/in/Corpus_striatum?f_ri=279027"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33700116" data-work_id="33700116" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33700116/Effects_of_GH_on_cognitive_function_in_elderly_patients_with_adult_onset_GH_deficiency_a_placebo_controlled_12_month_study">Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. Design: Single... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_33700116" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. Design: Single center, double-blind, randomized, placebo-controlled study of 52-week duration. Methods: Elderly GH therapy naïve GHD patients (nZ34; age range 60-77 years) were enrolled and randomized to receive placebo or GH therapy which was titrated to achieve a target IGF-I level of C1 to C2 S.D. of the normal mean for age. Cognitive function was assessed at baseline and after 24 and 52 weeks, using a computerized psychometric test package (Neurobehavioral Examination System-2). Results: The mean GH dose was 0.16G0.06 mg/day; mean IGF-I increased from 135G59 ng/ml at baseline to 213G77 ng/ml during active treatment. The GH-treated group had better mean serial digit learning scores compared with placebo group (P!0.05). Assessment of effect sizes showed that improvements in memory occurred with GH after 24 weeks. The overall adverse event rates were similar in the GH and the placebo group. Conclusion: This study indicates that GH replacement may be accompanied by improvement in certain measures of cognitive function in elderly patients with GHD.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33700116" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="20d79cfe1855aa7cf94c17d94b81ac76" rel="nofollow" data-download="{"attachment_id":53700612,"asset_id":33700116,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53700612/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33804298" href="https://independent.academia.edu/PiaBurman">Pia Burman</a><script data-card-contents-for-user="33804298" type="text/json">{"id":33804298,"first_name":"Pia","last_name":"Burman","domain_name":"independent","page_name":"PiaBurman","display_name":"Pia Burman","profile_url":"https://independent.academia.edu/PiaBurman?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_33700116 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33700116"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33700116, container: ".js-paper-rank-work_33700116", }); });</script></li><li class="js-percentile-work_33700116 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33700116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33700116"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33700116 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33700116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33700116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33700116]").text(description); $(".js-view-count-work_33700116").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33700116").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33700116"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4212" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="46858" rel="nofollow" href="https://www.academia.edu/Documents/in/Memory">Memory</a>, <script data-card-contents-for-ri="46858" type="text/json">{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50238" rel="nofollow" href="https://www.academia.edu/Documents/in/Affect">Affect</a>, <script data-card-contents-for-ri="50238" type="text/json">{"id":50238,"name":"Affect","url":"https://www.academia.edu/Documents/in/Affect?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="69565" rel="nofollow" href="https://www.academia.edu/Documents/in/Human_Growth_Hormone">Human Growth Hormone</a><script data-card-contents-for-ri="69565" type="text/json">{"id":69565,"name":"Human Growth Hormone","url":"https://www.academia.edu/Documents/in/Human_Growth_Hormone?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33700116]'), work: {"id":33700116,"title":"Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study","created_at":"2017-06-29T04:47:04.069-07:00","url":"https://www.academia.edu/33700116/Effects_of_GH_on_cognitive_function_in_elderly_patients_with_adult_onset_GH_deficiency_a_placebo_controlled_12_month_study?f_ri=279027","dom_id":"work_33700116","summary":"Objective: Young adults with childhood-onset GH deficiency (GHD) have reduced memory and attention, which can be improved by treatment with GH. Little information is available on cognitive function in elderly GHD patients. Design: Single center, double-blind, randomized, placebo-controlled study of 52-week duration. Methods: Elderly GH therapy naïve GHD patients (nZ34; age range 60-77 years) were enrolled and randomized to receive placebo or GH therapy which was titrated to achieve a target IGF-I level of C1 to C2 S.D. of the normal mean for age. Cognitive function was assessed at baseline and after 24 and 52 weeks, using a computerized psychometric test package (Neurobehavioral Examination System-2). Results: The mean GH dose was 0.16G0.06 mg/day; mean IGF-I increased from 135G59 ng/ml at baseline to 213G77 ng/ml during active treatment. The GH-treated group had better mean serial digit learning scores compared with placebo group (P!0.05). Assessment of effect sizes showed that improvements in memory occurred with GH after 24 weeks. The overall adverse event rates were similar in the GH and the placebo group. Conclusion: This study indicates that GH replacement may be accompanied by improvement in certain measures of cognitive function in elderly patients with GHD.","downloadable_attachments":[{"id":53700612,"asset_id":33700116,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33804298,"first_name":"Pia","last_name":"Burman","domain_name":"independent","page_name":"PiaBurman","display_name":"Pia Burman","profile_url":"https://independent.academia.edu/PiaBurman?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=279027","nofollow":true},{"id":46858,"name":"Memory","url":"https://www.academia.edu/Documents/in/Memory?f_ri=279027","nofollow":true},{"id":50238,"name":"Affect","url":"https://www.academia.edu/Documents/in/Affect?f_ri=279027","nofollow":true},{"id":69565,"name":"Human Growth Hormone","url":"https://www.academia.edu/Documents/in/Human_Growth_Hormone?f_ri=279027","nofollow":true},{"id":82845,"name":"Effect size","url":"https://www.academia.edu/Documents/in/Effect_size?f_ri=279027"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=279027"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":425873,"name":"Adverse Event","url":"https://www.academia.edu/Documents/in/Adverse_Event?f_ri=279027"},{"id":441653,"name":"Cognitive Function","url":"https://www.academia.edu/Documents/in/Cognitive_Function?f_ri=279027"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins?f_ri=279027"},{"id":2500734,"name":"Elderly patient","url":"https://www.academia.edu/Documents/in/Elderly_patient?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_30359838" data-work_id="30359838" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/30359838/Clinical_features_of_GH_deficiency_and_effects_of_3_years_of_GH_replacement_in_adults_with_controlled_Cushings_disease">Clinical features of GH deficiency and effects of 3 years of GH replacement in adults with controlled Cushing's disease</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30359838" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a2ed4140ef8c4705a8386212dd1309f4" rel="nofollow" data-download="{"attachment_id":50812473,"asset_id":30359838,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50812473/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20531638" rel="nofollow" href="https://independent.academia.edu/UllaFeldtRasmussen">Ulla Feldt-Rasmussen</a><script data-card-contents-for-user="20531638" type="text/json">{"id":20531638,"first_name":"Ulla","last_name":"Feldt-Rasmussen","domain_name":"independent","page_name":"UllaFeldtRasmussen","display_name":"Ulla Feldt-Rasmussen","profile_url":"https://independent.academia.edu/UllaFeldtRasmussen?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_30359838 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="30359838"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 30359838, container: ".js-paper-rank-work_30359838", }); });</script></li><li class="js-percentile-work_30359838 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30359838; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_30359838"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_30359838 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="30359838"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30359838; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30359838]").text(description); $(".js-view-count-work_30359838").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_30359838").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="30359838"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="154" rel="nofollow" href="https://www.academia.edu/Documents/in/Endocrinology">Endocrinology</a>, <script data-card-contents-for-ri="154" type="text/json">{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="3243" rel="nofollow" href="https://www.academia.edu/Documents/in/Nonparametric_Statistics">Nonparametric Statistics</a>, <script data-card-contents-for-ri="3243" type="text/json">{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="69565" rel="nofollow" href="https://www.academia.edu/Documents/in/Human_Growth_Hormone">Human Growth Hormone</a><script data-card-contents-for-ri="69565" type="text/json">{"id":69565,"name":"Human Growth Hormone","url":"https://www.academia.edu/Documents/in/Human_Growth_Hormone?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=30359838]'), work: {"id":30359838,"title":"Clinical features of GH deficiency and effects of 3 years of GH replacement in adults with controlled Cushing's disease","created_at":"2016-12-10T00:50:40.714-08:00","url":"https://www.academia.edu/30359838/Clinical_features_of_GH_deficiency_and_effects_of_3_years_of_GH_replacement_in_adults_with_controlled_Cushings_disease?f_ri=279027","dom_id":"work_30359838","summary":null,"downloadable_attachments":[{"id":50812473,"asset_id":30359838,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":20531638,"first_name":"Ulla","last_name":"Feldt-Rasmussen","domain_name":"independent","page_name":"UllaFeldtRasmussen","display_name":"Ulla Feldt-Rasmussen","profile_url":"https://independent.academia.edu/UllaFeldtRasmussen?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology?f_ri=279027","nofollow":true},{"id":3243,"name":"Nonparametric Statistics","url":"https://www.academia.edu/Documents/in/Nonparametric_Statistics?f_ri=279027","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true},{"id":69565,"name":"Human Growth Hormone","url":"https://www.academia.edu/Documents/in/Human_Growth_Hormone?f_ri=279027","nofollow":true},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=279027"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure?f_ri=279027"},{"id":90514,"name":"Cholesterol","url":"https://www.academia.edu/Documents/in/Cholesterol?f_ri=279027"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=279027"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies?f_ri=279027"},{"id":467226,"name":"Deficiency","url":"https://www.academia.edu/Documents/in/Deficiency?f_ri=279027"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=279027"},{"id":963748,"name":"Adenoma","url":"https://www.academia.edu/Documents/in/Adenoma?f_ri=279027"},{"id":968448,"name":"Deficit","url":"https://www.academia.edu/Documents/in/Deficit?f_ri=279027"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=279027"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=279027"},{"id":2443025,"name":"Pituitary Neoplasms","url":"https://www.academia.edu/Documents/in/Pituitary_Neoplasms?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15847336" data-work_id="15847336" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15847336/Turkey_and_Europe_The_Role_of_Migration">Turkey and Europe: The Role of Migration</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The Netherlands is not known for its opposing regimes of memory. There are two exceptions to this rule: the history of the German Occupation during the Second World War and the Dutch participation in the Atlantic slave trade and slavery.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15847336" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The Netherlands is not known for its opposing regimes of memory. There are two exceptions to this rule: the history of the German Occupation during the Second World War and the Dutch participation in the Atlantic slave trade and slavery. The relatively low numbers of survivors of the Holocaust in the Netherlands, as well as the volume and the profitability of the Dutch slave trade and slavery, and the importance of slave resistance in abolishing slavery in the Dutch Caribbean have produced conflicting views, especially between professional historians and the descendants of slaves living in the Netherlands.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15847336" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4bfd233e6d8c8f92f5cf38314953cc13" rel="nofollow" data-download="{"attachment_id":42856225,"asset_id":15847336,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42856225/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35029547" href="https://leidenuniv.academia.edu/PieterEmmer">Pieter Emmer</a><script data-card-contents-for-user="35029547" type="text/json">{"id":35029547,"first_name":"Pieter","last_name":"Emmer","domain_name":"leidenuniv","page_name":"PieterEmmer","display_name":"Pieter Emmer","profile_url":"https://leidenuniv.academia.edu/PieterEmmer?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15847336 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15847336"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15847336, container: ".js-paper-rank-work_15847336", }); });</script></li><li class="js-percentile-work_15847336 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15847336; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_15847336"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_15847336 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="15847336"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15847336; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15847336]").text(description); $(".js-view-count-work_15847336").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15847336").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15847336"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="28235" rel="nofollow" href="https://www.academia.edu/Documents/in/Multidisciplinary">Multidisciplinary</a>, <script data-card-contents-for-ri="28235" type="text/json">{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15847336]'), work: {"id":15847336,"title":"Turkey and Europe: The Role of Migration","created_at":"2015-09-18T05:58:22.935-07:00","url":"https://www.academia.edu/15847336/Turkey_and_Europe_The_Role_of_Migration?f_ri=279027","dom_id":"work_15847336","summary":"The Netherlands is not known for its opposing regimes of memory. There are two exceptions to this rule: the history of the German Occupation during the Second World War and the Dutch participation in the Atlantic slave trade and slavery. The relatively low numbers of survivors of the Holocaust in the Netherlands, as well as the volume and the profitability of the Dutch slave trade and slavery, and the importance of slave resistance in abolishing slavery in the Dutch Caribbean have produced conflicting views, especially between professional historians and the descendants of slaves living in the Netherlands.","downloadable_attachments":[{"id":42856225,"asset_id":15847336,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":35029547,"first_name":"Pieter","last_name":"Emmer","domain_name":"leidenuniv","page_name":"PieterEmmer","display_name":"Pieter Emmer","profile_url":"https://leidenuniv.academia.edu/PieterEmmer?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_1001831" data-work_id="1001831" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/1001831/Discrepancies_Between_Implicit_and_Explicit_Self_Esteem_Implications_for_Narcissism_and_Self_Esteem_Instability">Discrepancies Between Implicit and Explicit Self‐Esteem: Implications for Narcissism and Self‐Esteem Instability</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There appear to be two forms of high self-esteem: secure high self-esteem (which is often linked with psychological health) and fragile high self-esteem (which is generally associated with poor psychological adjustment and impaired... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_1001831" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There appear to be two forms of high self-esteem: secure high self-esteem (which is often linked with psychological health) and fragile high self-esteem (which is generally associated with poor psychological adjustment and impaired interpersonal relationships). Discrepant high self-esteem is a form of fragile self-esteem characterized by high explicit self-esteem and low implicit self-esteem. The present study examined whether discrepant high self-esteem was associated with narcissism and self-esteem instability in an undergraduate sample. Using multiple measures of implicit self-esteem, two basic findings emerged from the present study. First, participants with discrepant high self-esteem possessed the highest levels of narcissism. Second, participants with high explicit selfesteem and high implicit self-esteem displayed the most stable self-esteem. Findings are discussed in terms of secure and fragile high self-esteem.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/1001831" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="61f0784661f983ca13a9fcd4608e61bb" rel="nofollow" data-download="{"attachment_id":6131214,"asset_id":1001831,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/6131214/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="785568" href="https://oakland.academia.edu/VirgilZeiglerHill">Virgil Zeigler-Hill</a><script data-card-contents-for-user="785568" type="text/json">{"id":785568,"first_name":"Virgil","last_name":"Zeigler-Hill","domain_name":"oakland","page_name":"VirgilZeiglerHill","display_name":"Virgil Zeigler-Hill","profile_url":"https://oakland.academia.edu/VirgilZeiglerHill?f_ri=279027","photo":"https://0.academia-photos.com/785568/314763/372805/s65_virgil.zeigler-hill.jpg"}</script></span></span></li><li class="js-paper-rank-work_1001831 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="1001831"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 1001831, container: ".js-paper-rank-work_1001831", }); });</script></li><li class="js-percentile-work_1001831 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 1001831; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_1001831"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_1001831 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="1001831"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 1001831; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=1001831]").text(description); $(".js-view-count-work_1001831").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_1001831").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="1001831"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">24</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" rel="nofollow" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="237" rel="nofollow" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2672" rel="nofollow" href="https://www.academia.edu/Documents/in/Personality">Personality</a>, <script data-card-contents-for-ri="2672" type="text/json">{"id":2672,"name":"Personality","url":"https://www.academia.edu/Documents/in/Personality?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="2674" rel="nofollow" href="https://www.academia.edu/Documents/in/Intelligence">Intelligence</a><script data-card-contents-for-ri="2674" type="text/json">{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=1001831]'), work: {"id":1001831,"title":"Discrepancies Between Implicit and Explicit Self‐Esteem: Implications for Narcissism and Self‐Esteem Instability","created_at":"2011-10-11T23:31:02.912-07:00","url":"https://www.academia.edu/1001831/Discrepancies_Between_Implicit_and_Explicit_Self_Esteem_Implications_for_Narcissism_and_Self_Esteem_Instability?f_ri=279027","dom_id":"work_1001831","summary":"There appear to be two forms of high self-esteem: secure high self-esteem (which is often linked with psychological health) and fragile high self-esteem (which is generally associated with poor psychological adjustment and impaired interpersonal relationships). Discrepant high self-esteem is a form of fragile self-esteem characterized by high explicit self-esteem and low implicit self-esteem. The present study examined whether discrepant high self-esteem was associated with narcissism and self-esteem instability in an undergraduate sample. Using multiple measures of implicit self-esteem, two basic findings emerged from the present study. First, participants with discrepant high self-esteem possessed the highest levels of narcissism. Second, participants with high explicit selfesteem and high implicit self-esteem displayed the most stable self-esteem. Findings are discussed in terms of secure and fragile high self-esteem.","downloadable_attachments":[{"id":6131214,"asset_id":1001831,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":785568,"first_name":"Virgil","last_name":"Zeigler-Hill","domain_name":"oakland","page_name":"VirgilZeiglerHill","display_name":"Virgil Zeigler-Hill","profile_url":"https://oakland.academia.edu/VirgilZeiglerHill?f_ri=279027","photo":"https://0.academia-photos.com/785568/314763/372805/s65_virgil.zeigler-hill.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=279027","nofollow":true},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=279027","nofollow":true},{"id":2672,"name":"Personality","url":"https://www.academia.edu/Documents/in/Personality?f_ri=279027","nofollow":true},{"id":2674,"name":"Intelligence","url":"https://www.academia.edu/Documents/in/Intelligence?f_ri=279027","nofollow":true},{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression?f_ri=279027"},{"id":6291,"name":"Achievement Motivation","url":"https://www.academia.edu/Documents/in/Achievement_Motivation?f_ri=279027"},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027"},{"id":31468,"name":"Interpersonal Relationship","url":"https://www.academia.edu/Documents/in/Interpersonal_Relationship?f_ri=279027"},{"id":38676,"name":"Anxiety","url":"https://www.academia.edu/Documents/in/Anxiety?f_ri=279027"},{"id":42162,"name":"Emotions","url":"https://www.academia.edu/Documents/in/Emotions?f_ri=279027"},{"id":56132,"name":"Students","url":"https://www.academia.edu/Documents/in/Students?f_ri=279027"},{"id":73785,"name":"Personality Assessment Inventory","url":"https://www.academia.edu/Documents/in/Personality_Assessment_Inventory?f_ri=279027"},{"id":101101,"name":"Narcissism","url":"https://www.academia.edu/Documents/in/Narcissism?f_ri=279027"},{"id":123722,"name":"Defense Mechanisms","url":"https://www.academia.edu/Documents/in/Defense_Mechanisms?f_ri=279027"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=279027"},{"id":172809,"name":"Interpersonal Relations","url":"https://www.academia.edu/Documents/in/Interpersonal_Relations?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":321147,"name":"Self Concept","url":"https://www.academia.edu/Documents/in/Self_Concept?f_ri=279027"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=279027"},{"id":623821,"name":"ANXIETY","url":"https://www.academia.edu/Documents/in/ANXIETY-1?f_ri=279027"},{"id":864166,"name":"Psychological Adjustment","url":"https://www.academia.edu/Documents/in/Psychological_Adjustment?f_ri=279027"},{"id":1419742,"name":"Self Esteem","url":"https://www.academia.edu/Documents/in/Self_Esteem?f_ri=279027"},{"id":2467529,"name":"Psychiatric Status Rating Scales","url":"https://www.academia.edu/Documents/in/Psychiatric_Status_Rating_Scales?f_ri=279027"},{"id":2498386,"name":"Frontiers in Psychology","url":"https://www.academia.edu/Documents/in/Frontiers_in_Psychology?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_77979390" data-work_id="77979390" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/77979390/Clinical_and_genetic_analysis_of_spinocerebellar_ataxia_in_Mali">Clinical and genetic analysis of spinocerebellar ataxia in Mali</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Autosomal dominant cerebellar ataxia, currently denominated Spinocerebellar ataxia (SCAs) represents a heterogeneous group of neurodegenerative disorders affecting the cerebellum and its connections. We describe clinical and molecular... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_77979390" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Autosomal dominant cerebellar ataxia, currently denominated Spinocerebellar ataxia (SCAs) represents a heterogeneous group of neurodegenerative disorders affecting the cerebellum and its connections. We describe clinical and molecular findings in sixteen patients originating from Malian families, who suffer from progressive cerebellar ataxia syndrome. Molecular analysis allows genetic profiles of spinocerebellar ataxia to be distinguished. In seven patients, SCA type 2 (CAG) mutation was expanded from 39 to 43 repeats. SCA type 7(CAG)mutation was confirmed in six patients .Mutations were expanded from 49 to 59 repeats. In three patients, SCA type 3 was diagnosed and CAG mutation was expanded to 73 repeats. Conclusions-Our data suggests that the most frequent types of SCA are SCA2 and SCA7. However, further studies are needed to confirm these preliminary results.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77979390" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="44a704d965c75f4bd19865e86ad4c981" rel="nofollow" data-download="{"attachment_id":85184581,"asset_id":77979390,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/85184581/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="218439981" href="https://independent.academia.edu/MohamedTRAORE91">Mohamed TRAORE</a><script data-card-contents-for-user="218439981" type="text/json">{"id":218439981,"first_name":"Mohamed","last_name":"TRAORE","domain_name":"independent","page_name":"MohamedTRAORE91","display_name":"Mohamed TRAORE","profile_url":"https://independent.academia.edu/MohamedTRAORE91?f_ri=279027","photo":"https://gravatar.com/avatar/cab8b64a68e909bd38dcdf18c4f9b14a?s=65"}</script></span></span></li><li class="js-paper-rank-work_77979390 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="77979390"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 77979390, container: ".js-paper-rank-work_77979390", }); });</script></li><li class="js-percentile-work_77979390 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 77979390; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_77979390"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_77979390 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="77979390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77979390; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77979390]").text(description); $(".js-view-count-work_77979390").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_77979390").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="77979390"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52869" rel="nofollow" href="https://www.academia.edu/Documents/in/Mali">Mali</a>, <script data-card-contents-for-ri="52869" type="text/json">{"id":52869,"name":"Mali","url":"https://www.academia.edu/Documents/in/Mali?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="74780" rel="nofollow" href="https://www.academia.edu/Documents/in/Mutation">Mutation</a>, <script data-card-contents-for-ri="74780" type="text/json">{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="107154" rel="nofollow" href="https://www.academia.edu/Documents/in/Spinocerebellar_ataxia">Spinocerebellar ataxia</a><script data-card-contents-for-ri="107154" type="text/json">{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=77979390]'), work: {"id":77979390,"title":"Clinical and genetic analysis of spinocerebellar ataxia in Mali","created_at":"2022-04-29T10:17:32.278-07:00","url":"https://www.academia.edu/77979390/Clinical_and_genetic_analysis_of_spinocerebellar_ataxia_in_Mali?f_ri=279027","dom_id":"work_77979390","summary":"Autosomal dominant cerebellar ataxia, currently denominated Spinocerebellar ataxia (SCAs) represents a heterogeneous group of neurodegenerative disorders affecting the cerebellum and its connections. We describe clinical and molecular findings in sixteen patients originating from Malian families, who suffer from progressive cerebellar ataxia syndrome. Molecular analysis allows genetic profiles of spinocerebellar ataxia to be distinguished. In seven patients, SCA type 2 (CAG) mutation was expanded from 39 to 43 repeats. SCA type 7(CAG)mutation was confirmed in six patients .Mutations were expanded from 49 to 59 repeats. In three patients, SCA type 3 was diagnosed and CAG mutation was expanded to 73 repeats. Conclusions-Our data suggests that the most frequent types of SCA are SCA2 and SCA7. However, further studies are needed to confirm these preliminary results.","downloadable_attachments":[{"id":85184581,"asset_id":77979390,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":218439981,"first_name":"Mohamed","last_name":"TRAORE","domain_name":"independent","page_name":"MohamedTRAORE91","display_name":"Mohamed TRAORE","profile_url":"https://independent.academia.edu/MohamedTRAORE91?f_ri=279027","photo":"https://gravatar.com/avatar/cab8b64a68e909bd38dcdf18c4f9b14a?s=65"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":52869,"name":"Mali","url":"https://www.academia.edu/Documents/in/Mali?f_ri=279027","nofollow":true},{"id":74780,"name":"Mutation","url":"https://www.academia.edu/Documents/in/Mutation?f_ri=279027","nofollow":true},{"id":107154,"name":"Spinocerebellar ataxia","url":"https://www.academia.edu/Documents/in/Spinocerebellar_ataxia?f_ri=279027","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=279027"},{"id":643228,"name":"Ataxia","url":"https://www.academia.edu/Documents/in/Ataxia?f_ri=279027"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=279027"},{"id":3203621,"name":"Gene frequency","url":"https://www.academia.edu/Documents/in/Gene_frequency?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72416097" data-work_id="72416097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72416097/Central_nervous_system_atypical_teratoid_rhabdoid_tumours_The_Canadian_Paediatric_Brain_Tumour_Consortium_experience">Central nervous system atypical teratoid rhabdoid tumours: The Canadian Paediatric Brain Tumour Consortium experience</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Atypical teratoid rhabdoid tumours (ATRT) are aggressive brain tumours mostly occurring in early childhood. Largest published series arise from registries and institutional experiences (1-4). The aim of this report is to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72416097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Atypical teratoid rhabdoid tumours (ATRT) are aggressive brain tumours mostly occurring in early childhood. Largest published series arise from registries and institutional experiences (1-4). The aim of this report is to provide population-based data to further characterise this rare entity and to delineate prognostic factors. Patients and methods: A national retrospective study of children 618 years diagnosed with a central nervous system (CNS) ATRT between 1995 and 2007 was undertaken. All cases underwent central pathology review. Results: There were 50 patients (31 males; median age at diagnosis of 16.7 months). Twelve patients were >36 months. Infratentorial location accounted for 52% of all cases. Nineteen patients (38%) had metastatic disease. Fifteen (30%) underwent gross total resection (GTR). Ten patients (20%) underwent palliation. Among the 40 remaining patients, 22 received conventional chemotherapy and 18 received high dose chemotherapy regimens (HDC); nine received intrathecal chemotherapy and 15 received adjuvant radiation. Thirty of the 40 treated patients relapsed/progressed at a median time of 5.5 months (0-32). The median survival time of the entire cohort was 13.5 months (1-117.5 months).</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72416097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eccbc9107a94129a4d279834ec024b5b" rel="nofollow" data-download="{"attachment_id":81349727,"asset_id":72416097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81349727/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39232709" href="https://independent.academia.edu/DonnaJohnston3">Donna Johnston</a><script data-card-contents-for-user="39232709" type="text/json">{"id":39232709,"first_name":"Donna","last_name":"Johnston","domain_name":"independent","page_name":"DonnaJohnston3","display_name":"Donna Johnston","profile_url":"https://independent.academia.edu/DonnaJohnston3?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72416097 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72416097"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72416097, container: ".js-paper-rank-work_72416097", }); });</script></li><li class="js-percentile-work_72416097 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72416097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_72416097"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_72416097 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="72416097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72416097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72416097]").text(description); $(".js-view-count-work_72416097").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72416097").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72416097"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="10030" rel="nofollow" href="https://www.academia.edu/Documents/in/Radiation_Therapy">Radiation Therapy</a>, <script data-card-contents-for-ri="10030" type="text/json">{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" rel="nofollow" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="30140" rel="nofollow" href="https://www.academia.edu/Documents/in/Early_Childhood">Early Childhood</a><script data-card-contents-for-ri="30140" type="text/json">{"id":30140,"name":"Early Childhood","url":"https://www.academia.edu/Documents/in/Early_Childhood?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72416097]'), work: {"id":72416097,"title":"Central nervous system atypical teratoid rhabdoid tumours: The Canadian Paediatric Brain Tumour Consortium experience","created_at":"2022-02-24T07:26:57.067-08:00","url":"https://www.academia.edu/72416097/Central_nervous_system_atypical_teratoid_rhabdoid_tumours_The_Canadian_Paediatric_Brain_Tumour_Consortium_experience?f_ri=279027","dom_id":"work_72416097","summary":"Background: Atypical teratoid rhabdoid tumours (ATRT) are aggressive brain tumours mostly occurring in early childhood. Largest published series arise from registries and institutional experiences (1-4). The aim of this report is to provide population-based data to further characterise this rare entity and to delineate prognostic factors. Patients and methods: A national retrospective study of children 618 years diagnosed with a central nervous system (CNS) ATRT between 1995 and 2007 was undertaken. All cases underwent central pathology review. Results: There were 50 patients (31 males; median age at diagnosis of 16.7 months). Twelve patients were \u003e36 months. Infratentorial location accounted for 52% of all cases. Nineteen patients (38%) had metastatic disease. Fifteen (30%) underwent gross total resection (GTR). Ten patients (20%) underwent palliation. Among the 40 remaining patients, 22 received conventional chemotherapy and 18 received high dose chemotherapy regimens (HDC); nine received intrathecal chemotherapy and 15 received adjuvant radiation. Thirty of the 40 treated patients relapsed/progressed at a median time of 5.5 months (0-32). The median survival time of the entire cohort was 13.5 months (1-117.5 months).","downloadable_attachments":[{"id":81349727,"asset_id":72416097,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39232709,"first_name":"Donna","last_name":"Johnston","domain_name":"independent","page_name":"DonnaJohnston3","display_name":"Donna Johnston","profile_url":"https://independent.academia.edu/DonnaJohnston3?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy?f_ri=279027","nofollow":true},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=279027","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":30140,"name":"Early Childhood","url":"https://www.academia.edu/Documents/in/Early_Childhood?f_ri=279027","nofollow":true},{"id":54114,"name":"Canada","url":"https://www.academia.edu/Documents/in/Canada?f_ri=279027"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027"},{"id":121179,"name":"Population based study","url":"https://www.academia.edu/Documents/in/Population_based_study?f_ri=279027"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=279027"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":403795,"name":"Paediatric","url":"https://www.academia.edu/Documents/in/Paediatric?f_ri=279027"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=279027"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=279027"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=279027"},{"id":2153358,"name":"Brain Tumour","url":"https://www.academia.edu/Documents/in/Brain_Tumour?f_ri=279027"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=279027"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_65884066" data-work_id="65884066" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/65884066/Atrioventricular_septal_defect_and_tetralogy_of_Fallot_a_15_year_experience">Atrioventricular septal defect and tetralogy of Fallot: a 15-year experience</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65884066" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9dc27adad33c724b71e190b34839b3cb" rel="nofollow" data-download="{"attachment_id":77288061,"asset_id":65884066,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77288061/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="191129505" rel="nofollow" href="https://independent.academia.edu/suhaibmohammed13">suhaib mohammed</a><script data-card-contents-for-user="191129505" type="text/json">{"id":191129505,"first_name":"suhaib","last_name":"mohammed","domain_name":"independent","page_name":"suhaibmohammed13","display_name":"suhaib mohammed","profile_url":"https://independent.academia.edu/suhaibmohammed13?f_ri=279027","photo":"https://0.academia-photos.com/191129505/54174951/42315217/s65_suhaib.mohammed.png"}</script></span></span></li><li class="js-paper-rank-work_65884066 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65884066"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65884066, container: ".js-paper-rank-work_65884066", }); });</script></li><li class="js-percentile-work_65884066 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65884066; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_65884066"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_65884066 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="65884066"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65884066; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65884066]").text(description); $(".js-view-count-work_65884066").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_65884066").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="65884066"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4482" rel="nofollow" href="https://www.academia.edu/Documents/in/Palliative_Care">Palliative Care</a>, <script data-card-contents-for-ri="4482" type="text/json">{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="39549" rel="nofollow" href="https://www.academia.edu/Documents/in/Czech_Republic">Czech Republic</a><script data-card-contents-for-ri="39549" type="text/json">{"id":39549,"name":"Czech Republic","url":"https://www.academia.edu/Documents/in/Czech_Republic?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=65884066]'), work: {"id":65884066,"title":"Atrioventricular septal defect and tetralogy of Fallot: a 15-year experience","created_at":"2021-12-24T11:30:15.600-08:00","url":"https://www.academia.edu/65884066/Atrioventricular_septal_defect_and_tetralogy_of_Fallot_a_15_year_experience?f_ri=279027","dom_id":"work_65884066","summary":null,"downloadable_attachments":[{"id":77288061,"asset_id":65884066,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":191129505,"first_name":"suhaib","last_name":"mohammed","domain_name":"independent","page_name":"suhaibmohammed13","display_name":"suhaib mohammed","profile_url":"https://independent.academia.edu/suhaibmohammed13?f_ri=279027","photo":"https://0.academia-photos.com/191129505/54174951/42315217/s65_suhaib.mohammed.png"}],"research_interests":[{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=279027","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":39549,"name":"Czech Republic","url":"https://www.academia.edu/Documents/in/Czech_Republic?f_ri=279027","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":291274,"name":"Great Britain","url":"https://www.academia.edu/Documents/in/Great_Britain?f_ri=279027"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=279027"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=279027"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=279027"},{"id":493102,"name":"Conservation Management","url":"https://www.academia.edu/Documents/in/Conservation_Management?f_ri=279027"},{"id":640868,"name":"Management Strategy","url":"https://www.academia.edu/Documents/in/Management_Strategy?f_ri=279027"},{"id":2482067,"name":"Reoperation","url":"https://www.academia.edu/Documents/in/Reoperation?f_ri=279027"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=279027"},{"id":2721270,"name":"Tetralogy of Fallot","url":"https://www.academia.edu/Documents/in/Tetralogy_of_Fallot?f_ri=279027"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=279027"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_65040171" data-work_id="65040171" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/65040171/Omega_3_fatty_acids_in_major_depressive_disorder_A_preliminary_double_blind_placebo_controlled_trial">Omega-3 fatty acids in major depressive disorder:: A preliminary double-blind, placebo-controlled trial</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Patients with depression have been extensively reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low eicosapentaenoic acid and docosahexaenoic acid in cell tissue... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_65040171" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Patients with depression have been extensively reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low eicosapentaenoic acid and docosahexaenoic acid in cell tissue contents (red blood cell membrane, plasma, etc.) and dietary intake. However, more evidence is needed to support its relation. In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g / day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group (P,0.001). From the preliminary findings in this study, omega-3 PUFAs could improve the short-term course of illness and were well tolerated in patients with major depressive disorder.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65040171" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="649ff00aa950048ef9976530ef17acda" rel="nofollow" data-download="{"attachment_id":76799402,"asset_id":65040171,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76799402/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44948169" href="https://independent.academia.edu/SyHuang3">Shih-Yi Huang</a><script data-card-contents-for-user="44948169" type="text/json">{"id":44948169,"first_name":"Shih-Yi","last_name":"Huang","domain_name":"independent","page_name":"SyHuang3","display_name":"Shih-Yi Huang","profile_url":"https://independent.academia.edu/SyHuang3?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_65040171 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65040171"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65040171, container: ".js-paper-rank-work_65040171", }); });</script></li><li class="js-percentile-work_65040171 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65040171; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_65040171"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_65040171 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="65040171"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65040171; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65040171]").text(description); $(".js-view-count-work_65040171").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_65040171").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="65040171"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="77794" rel="nofollow" href="https://www.academia.edu/Documents/in/Major_Depressive_Disorder">Major Depressive Disorder</a>, <script data-card-contents-for-ri="77794" type="text/json">{"id":77794,"name":"Major Depressive Disorder","url":"https://www.academia.edu/Documents/in/Major_Depressive_Disorder?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="158052" rel="nofollow" href="https://www.academia.edu/Documents/in/Placebos">Placebos</a>, <script data-card-contents-for-ri="158052" type="text/json">{"id":158052,"name":"Placebos","url":"https://www.academia.edu/Documents/in/Placebos?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="245071" rel="nofollow" href="https://www.academia.edu/Documents/in/Rating_Scale">Rating Scale</a><script data-card-contents-for-ri="245071" type="text/json">{"id":245071,"name":"Rating Scale","url":"https://www.academia.edu/Documents/in/Rating_Scale?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=65040171]'), work: {"id":65040171,"title":"Omega-3 fatty acids in major depressive disorder:: A preliminary double-blind, placebo-controlled trial","created_at":"2021-12-18T18:14:18.942-08:00","url":"https://www.academia.edu/65040171/Omega_3_fatty_acids_in_major_depressive_disorder_A_preliminary_double_blind_placebo_controlled_trial?f_ri=279027","dom_id":"work_65040171","summary":"Patients with depression have been extensively reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low eicosapentaenoic acid and docosahexaenoic acid in cell tissue contents (red blood cell membrane, plasma, etc.) and dietary intake. However, more evidence is needed to support its relation. In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g / day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group (P,0.001). From the preliminary findings in this study, omega-3 PUFAs could improve the short-term course of illness and were well tolerated in patients with major depressive disorder.","downloadable_attachments":[{"id":76799402,"asset_id":65040171,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44948169,"first_name":"Shih-Yi","last_name":"Huang","domain_name":"independent","page_name":"SyHuang3","display_name":"Shih-Yi Huang","profile_url":"https://independent.academia.edu/SyHuang3?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true},{"id":77794,"name":"Major Depressive Disorder","url":"https://www.academia.edu/Documents/in/Major_Depressive_Disorder?f_ri=279027","nofollow":true},{"id":158052,"name":"Placebos","url":"https://www.academia.edu/Documents/in/Placebos?f_ri=279027","nofollow":true},{"id":245071,"name":"Rating Scale","url":"https://www.academia.edu/Documents/in/Rating_Scale?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=279027"},{"id":579219,"name":"Red blood cell","url":"https://www.academia.edu/Documents/in/Red_blood_cell?f_ri=279027"},{"id":719195,"name":"Nutrition therapy","url":"https://www.academia.edu/Documents/in/Nutrition_therapy?f_ri=279027"},{"id":1218481,"name":"Archives General Psychiatry","url":"https://www.academia.edu/Documents/in/Archives_General_Psychiatry?f_ri=279027"},{"id":1593322,"name":"Eicosapentaenoic Acid","url":"https://www.academia.edu/Documents/in/Eicosapentaenoic_Acid?f_ri=279027"},{"id":1611350,"name":"Docosahexaenoic Acid","url":"https://www.academia.edu/Documents/in/Docosahexaenoic_Acid?f_ri=279027"},{"id":2467529,"name":"Psychiatric Status Rating Scales","url":"https://www.academia.edu/Documents/in/Psychiatric_Status_Rating_Scales?f_ri=279027"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=279027"},{"id":3102540,"name":"Dietary intake","url":"https://www.academia.edu/Documents/in/Dietary_intake-1?f_ri=279027"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55711571" data-work_id="55711571" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/55711571/An_unusual_etiology_of_osteomyelitis">An unusual etiology of osteomyelitis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Abstract While skin and soft-tissue complication of varicella are well known, osteomyelitis secondary to varicella is rarely reported in the literature. We describe a case of 3-year-child with varicella associated with pandiaphysal... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_55711571" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Abstract While skin and soft-tissue complication of varicella are well known, osteomyelitis secondary to varicella is rarely reported in the literature. We describe a case of 3-year-child with varicella associated with pandiaphysal osteomyelitis caused by streptococcus type A ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55711571" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="184151405" href="https://independent.academia.edu/abderrazekabid">abderrazek abid</a><script data-card-contents-for-user="184151405" type="text/json">{"id":184151405,"first_name":"abderrazek","last_name":"abid","domain_name":"independent","page_name":"abderrazekabid","display_name":"abderrazek abid","profile_url":"https://independent.academia.edu/abderrazekabid?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55711571 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55711571"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55711571, container: ".js-paper-rank-work_55711571", }); });</script></li><li class="js-percentile-work_55711571 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 55711571; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_55711571"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_55711571 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="55711571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 55711571; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=55711571]").text(description); $(".js-view-count-work_55711571").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_55711571").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="55711571"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="631028" rel="nofollow" href="https://www.academia.edu/Documents/in/Soft_Tissue">Soft Tissue</a><script data-card-contents-for-ri="631028" type="text/json">{"id":631028,"name":"Soft Tissue","url":"https://www.academia.edu/Documents/in/Soft_Tissue?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=55711571]'), work: {"id":55711571,"title":"An unusual etiology of osteomyelitis","created_at":"2021-10-05T13:02:20.072-07:00","url":"https://www.academia.edu/55711571/An_unusual_etiology_of_osteomyelitis?f_ri=279027","dom_id":"work_55711571","summary":"Abstract While skin and soft-tissue complication of varicella are well known, osteomyelitis secondary to varicella is rarely reported in the literature. We describe a case of 3-year-child with varicella associated with pandiaphysal osteomyelitis caused by streptococcus type A ...","downloadable_attachments":[],"ordered_authors":[{"id":184151405,"first_name":"abderrazek","last_name":"abid","domain_name":"independent","page_name":"abderrazekabid","display_name":"abderrazek abid","profile_url":"https://independent.academia.edu/abderrazekabid?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":631028,"name":"Soft Tissue","url":"https://www.academia.edu/Documents/in/Soft_Tissue?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_54190147" data-work_id="54190147" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/54190147/Cigarette_smoking_and_occupational_noise_induced_hearing_loss">Cigarette smoking and occupational noise-induced hearing loss</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Noise is the most common occupational hazard. Noise-induced hearing loss (NIHL) is a known occupational disease. The economic costs of NIHL have been estimated to be billions of dollars. Besides, cigarette smoking is a common... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_54190147" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Noise is the most common occupational hazard. Noise-induced hearing loss (NIHL) is a known occupational disease. The economic costs of NIHL have been estimated to be billions of dollars. Besides, cigarette smoking is a common habit worldwide. Methods: In a cross-sectional study, we surveyed the effect of smoking on NIHL in 504 workers in a large wagon manufacturing company exposed to noise >85 dBA. All required data were obtained using direct interview and questionnaires. To determine noise exposure level, we used industrial hygienist's reports of sound level measurements. A qualified audiologist assessed hearing status using standardized audiometric examination. Results: We concluded that the frequency of hearing loss in smokers was higher than non-smokers [based on Model 1: odds ratio (OR) = 9.35, 95% confidence interval (CI) = 5.74-15.22 and P-value < 0.001; and based on Model 2: OR = 9.06, 95% CI = 5.93-13.84 and P-value < 0.001]. Besides, these results were confirmed by logistic regression statistical method. Conclusions: It can be concluded that smoking may accelerate NIHL, but for confirming this opinion, further studies are warranted.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/54190147" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c5070d77563371a65095d1f9d088f8c9" rel="nofollow" data-download="{"attachment_id":70674034,"asset_id":54190147,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70674034/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="9780253" href="https://independent.academia.edu/AmirHooshangMehrparvar">Amir Hooshang Mehrparvar</a><script data-card-contents-for-user="9780253" type="text/json">{"id":9780253,"first_name":"Amir Hooshang","last_name":"Mehrparvar","domain_name":"independent","page_name":"AmirHooshangMehrparvar","display_name":"Amir Hooshang Mehrparvar","profile_url":"https://independent.academia.edu/AmirHooshangMehrparvar?f_ri=279027","photo":"https://0.academia-photos.com/9780253/72345907/60808964/s65_amir_hooshang.mehrparvar.jpeg"}</script></span></span></li><li class="js-paper-rank-work_54190147 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="54190147"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 54190147, container: ".js-paper-rank-work_54190147", }); });</script></li><li class="js-percentile-work_54190147 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 54190147; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_54190147"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_54190147 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="54190147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 54190147; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=54190147]").text(description); $(".js-view-count-work_54190147").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_54190147").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="54190147"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="16506" rel="nofollow" href="https://www.academia.edu/Documents/in/Noise_Induced_Hearing_Loss">Noise Induced Hearing Loss</a>, <script data-card-contents-for-ri="16506" type="text/json">{"id":16506,"name":"Noise Induced Hearing Loss","url":"https://www.academia.edu/Documents/in/Noise_Induced_Hearing_Loss?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="33666" rel="nofollow" href="https://www.academia.edu/Documents/in/European_Public_Health_Policies">European Public Health Policies</a>, <script data-card-contents-for-ri="33666" type="text/json">{"id":33666,"name":"European Public Health Policies","url":"https://www.academia.edu/Documents/in/European_Public_Health_Policies?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="41274" rel="nofollow" href="https://www.academia.edu/Documents/in/Iran">Iran</a>, <script data-card-contents-for-ri="41274" type="text/json">{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="75318" rel="nofollow" href="https://www.academia.edu/Documents/in/Smoking">Smoking</a><script data-card-contents-for-ri="75318" type="text/json">{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=54190147]'), work: {"id":54190147,"title":"Cigarette smoking and occupational noise-induced hearing loss","created_at":"2021-09-30T00:51:49.787-07:00","url":"https://www.academia.edu/54190147/Cigarette_smoking_and_occupational_noise_induced_hearing_loss?f_ri=279027","dom_id":"work_54190147","summary":"Background: Noise is the most common occupational hazard. Noise-induced hearing loss (NIHL) is a known occupational disease. The economic costs of NIHL have been estimated to be billions of dollars. Besides, cigarette smoking is a common habit worldwide. Methods: In a cross-sectional study, we surveyed the effect of smoking on NIHL in 504 workers in a large wagon manufacturing company exposed to noise \u003e85 dBA. All required data were obtained using direct interview and questionnaires. To determine noise exposure level, we used industrial hygienist's reports of sound level measurements. A qualified audiologist assessed hearing status using standardized audiometric examination. Results: We concluded that the frequency of hearing loss in smokers was higher than non-smokers [based on Model 1: odds ratio (OR) = 9.35, 95% confidence interval (CI) = 5.74-15.22 and P-value \u003c 0.001; and based on Model 2: OR = 9.06, 95% CI = 5.93-13.84 and P-value \u003c 0.001]. Besides, these results were confirmed by logistic regression statistical method. Conclusions: It can be concluded that smoking may accelerate NIHL, but for confirming this opinion, further studies are warranted.","downloadable_attachments":[{"id":70674034,"asset_id":54190147,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":9780253,"first_name":"Amir Hooshang","last_name":"Mehrparvar","domain_name":"independent","page_name":"AmirHooshangMehrparvar","display_name":"Amir Hooshang Mehrparvar","profile_url":"https://independent.academia.edu/AmirHooshangMehrparvar?f_ri=279027","photo":"https://0.academia-photos.com/9780253/72345907/60808964/s65_amir_hooshang.mehrparvar.jpeg"}],"research_interests":[{"id":16506,"name":"Noise Induced Hearing Loss","url":"https://www.academia.edu/Documents/in/Noise_Induced_Hearing_Loss?f_ri=279027","nofollow":true},{"id":33666,"name":"European Public Health Policies","url":"https://www.academia.edu/Documents/in/European_Public_Health_Policies?f_ri=279027","nofollow":true},{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=279027","nofollow":true},{"id":75318,"name":"Smoking","url":"https://www.academia.edu/Documents/in/Smoking?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=279027"},{"id":396914,"name":"Occupational Exposure","url":"https://www.academia.edu/Documents/in/Occupational_Exposure?f_ri=279027"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=279027"},{"id":437772,"name":"Odds ratio","url":"https://www.academia.edu/Documents/in/Odds_ratio?f_ri=279027"},{"id":557260,"name":"Health surveys","url":"https://www.academia.edu/Documents/in/Health_surveys?f_ri=279027"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=279027"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=279027"},{"id":1725725,"name":"Audiometry","url":"https://www.academia.edu/Documents/in/Audiometry?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49901216" data-work_id="49901216" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49901216/Step_by_step_development_of_clinical_care_pathways_for_older_cancer_patients_Necessary_or_desirable">Step by step development of clinical care pathways for older cancer patients: Necessary or desirable?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Medical and nursing staff in oncology for older cancer patients are confronted with a range of problems including co-morbidity, poly-pharmacy, cognitive impairments, emotional problems, functional limitations, sensory impairment and a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49901216" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Medical and nursing staff in oncology for older cancer patients are confronted with a range of problems including co-morbidity, poly-pharmacy, cognitive impairments, emotional problems, functional limitations, sensory impairment and a lack of social support. Comprehensive geriatric assessment identifies many of the existing problems and can be used to estimate life expectancy and tolerance of treatment. However, health care providers have to interpret and apply the medical and nursing information and must deal with specific problems and care needs throughout the continuum of cancer care. Imperfect interdisciplinary communication, cooperation and patient-provider communication may further complicate the care actually delivered. A clinical care pathway aims to improve continuity, increase multidisciplinary tuning and deliver appropriate patient education, treatment and care for vulnerable older cancer patients. This paper gives an overview of common problems in older cancer patients and addresses communication barriers through the development of clinical care pathways in geriatric oncology.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49901216" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="24f9e2a7e1f3b63c285997eeb9c69229" rel="nofollow" data-download="{"attachment_id":68086570,"asset_id":49901216,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68086570/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32696289" href="https://independent.academia.edu/JuliaVanWeert">Julia Van Weert</a><script data-card-contents-for-user="32696289" type="text/json">{"id":32696289,"first_name":"Julia Van","last_name":"Weert","domain_name":"independent","page_name":"JuliaVanWeert","display_name":"Julia Van Weert","profile_url":"https://independent.academia.edu/JuliaVanWeert?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_49901216 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49901216"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49901216, container: ".js-paper-rank-work_49901216", }); });</script></li><li class="js-percentile-work_49901216 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 49901216; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_49901216"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_49901216 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="49901216"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 49901216; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=49901216]").text(description); $(".js-view-count-work_49901216").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_49901216").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="49901216"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="617" rel="nofollow" href="https://www.academia.edu/Documents/in/Geriatrics">Geriatrics</a>, <script data-card-contents-for-ri="617" type="text/json">{"id":617,"name":"Geriatrics","url":"https://www.academia.edu/Documents/in/Geriatrics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="859" rel="nofollow" href="https://www.academia.edu/Documents/in/Communication">Communication</a>, <script data-card-contents-for-ri="859" type="text/json">{"id":859,"name":"Communication","url":"https://www.academia.edu/Documents/in/Communication?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11015" rel="nofollow" href="https://www.academia.edu/Documents/in/Social_Support">Social Support</a><script data-card-contents-for-ri="11015" type="text/json">{"id":11015,"name":"Social Support","url":"https://www.academia.edu/Documents/in/Social_Support?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=49901216]'), work: {"id":49901216,"title":"Step by step development of clinical care pathways for older cancer patients: Necessary or desirable?","created_at":"2021-07-14T06:29:47.104-07:00","url":"https://www.academia.edu/49901216/Step_by_step_development_of_clinical_care_pathways_for_older_cancer_patients_Necessary_or_desirable?f_ri=279027","dom_id":"work_49901216","summary":"Medical and nursing staff in oncology for older cancer patients are confronted with a range of problems including co-morbidity, poly-pharmacy, cognitive impairments, emotional problems, functional limitations, sensory impairment and a lack of social support. Comprehensive geriatric assessment identifies many of the existing problems and can be used to estimate life expectancy and tolerance of treatment. However, health care providers have to interpret and apply the medical and nursing information and must deal with specific problems and care needs throughout the continuum of cancer care. Imperfect interdisciplinary communication, cooperation and patient-provider communication may further complicate the care actually delivered. A clinical care pathway aims to improve continuity, increase multidisciplinary tuning and deliver appropriate patient education, treatment and care for vulnerable older cancer patients. This paper gives an overview of common problems in older cancer patients and addresses communication barriers through the development of clinical care pathways in geriatric oncology.","downloadable_attachments":[{"id":68086570,"asset_id":49901216,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32696289,"first_name":"Julia Van","last_name":"Weert","domain_name":"independent","page_name":"JuliaVanWeert","display_name":"Julia Van Weert","profile_url":"https://independent.academia.edu/JuliaVanWeert?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":617,"name":"Geriatrics","url":"https://www.academia.edu/Documents/in/Geriatrics?f_ri=279027","nofollow":true},{"id":859,"name":"Communication","url":"https://www.academia.edu/Documents/in/Communication?f_ri=279027","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=279027","nofollow":true},{"id":11015,"name":"Social Support","url":"https://www.academia.edu/Documents/in/Social_Support?f_ri=279027","nofollow":true},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary?f_ri=279027"},{"id":52710,"name":"Patient education","url":"https://www.academia.edu/Documents/in/Patient_education?f_ri=279027"},{"id":59372,"name":"Malnutrition","url":"https://www.academia.edu/Documents/in/Malnutrition?f_ri=279027"},{"id":172892,"name":"Life Expectancy","url":"https://www.academia.edu/Documents/in/Life_Expectancy?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":284201,"name":"Mood Disorders","url":"https://www.academia.edu/Documents/in/Mood_Disorders?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":341121,"name":"Cognitive impairment","url":"https://www.academia.edu/Documents/in/Cognitive_impairment?f_ri=279027"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=279027"},{"id":532278,"name":"Cancer Patient","url":"https://www.academia.edu/Documents/in/Cancer_Patient?f_ri=279027"},{"id":584602,"name":"Geriatric Assessment","url":"https://www.academia.edu/Documents/in/Geriatric_Assessment?f_ri=279027"},{"id":791585,"name":"Health Care Provider","url":"https://www.academia.edu/Documents/in/Health_Care_Provider?f_ri=279027"},{"id":1627527,"name":"Cognition disorders","url":"https://www.academia.edu/Documents/in/Cognition_disorders?f_ri=279027"},{"id":2060696,"name":"Health services for the aged","url":"https://www.academia.edu/Documents/in/Health_services_for_the_aged?f_ri=279027"},{"id":2723721,"name":"professional patient relations","url":"https://www.academia.edu/Documents/in/professional_patient_relations?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48751805" data-work_id="48751805" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48751805/TSH_receptor_antibodies_do_not_alter_the_function_of_gonadotropin_receptors_stably_expressed_in_eukaryotic_cells">TSH receptor antibodies do not alter the function of gonadotropin receptors stably expressed in eukaryotic cells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">OBJECTIVE: TSH receptor (TSHr) mediates the activating action of TSH on the thyroid gland resulting in the growth and proliferation of thyrocytes and thyroid hormone production. TSHr is a major autoantigen in…</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48751805" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d67ba8fb1a03b760d7c865c9a8ad4061" rel="nofollow" data-download="{"attachment_id":67204226,"asset_id":48751805,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67204226/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37397817" href="https://independent.academia.edu/FilomenaCetani">Filomena Cetani</a><script data-card-contents-for-user="37397817" type="text/json">{"id":37397817,"first_name":"Filomena","last_name":"Cetani","domain_name":"independent","page_name":"FilomenaCetani","display_name":"Filomena Cetani","profile_url":"https://independent.academia.edu/FilomenaCetani?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48751805 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48751805"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48751805, container: ".js-paper-rank-work_48751805", }); });</script></li><li class="js-percentile-work_48751805 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48751805; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48751805"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48751805 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48751805"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48751805; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48751805]").text(description); $(".js-view-count-work_48751805").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48751805").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48751805"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="57808" rel="nofollow" href="https://www.academia.edu/Documents/in/Cell_line">Cell line</a>, <script data-card-contents-for-ri="57808" type="text/json">{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="76078" rel="nofollow" href="https://www.academia.edu/Documents/in/Thyroid_gland">Thyroid gland</a>, <script data-card-contents-for-ri="76078" type="text/json">{"id":76078,"name":"Thyroid gland","url":"https://www.academia.edu/Documents/in/Thyroid_gland?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="92680" rel="nofollow" href="https://www.academia.edu/Documents/in/cyclic_AMP">cyclic AMP</a>, <script data-card-contents-for-ri="92680" type="text/json">{"id":92680,"name":"cyclic AMP","url":"https://www.academia.edu/Documents/in/cyclic_AMP?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48751805]'), work: {"id":48751805,"title":"TSH receptor antibodies do not alter the function of gonadotropin receptors stably expressed in eukaryotic cells","created_at":"2021-05-05T11:09:51.370-07:00","url":"https://www.academia.edu/48751805/TSH_receptor_antibodies_do_not_alter_the_function_of_gonadotropin_receptors_stably_expressed_in_eukaryotic_cells?f_ri=279027","dom_id":"work_48751805","summary":"OBJECTIVE: TSH receptor (TSHr) mediates the activating action of TSH on the thyroid gland resulting in the growth and proliferation of thyrocytes and thyroid hormone production. TSHr is a major autoantigen in…","downloadable_attachments":[{"id":67204226,"asset_id":48751805,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":37397817,"first_name":"Filomena","last_name":"Cetani","domain_name":"independent","page_name":"FilomenaCetani","display_name":"Filomena Cetani","profile_url":"https://independent.academia.edu/FilomenaCetani?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=279027","nofollow":true},{"id":76078,"name":"Thyroid gland","url":"https://www.academia.edu/Documents/in/Thyroid_gland?f_ri=279027","nofollow":true},{"id":92680,"name":"cyclic AMP","url":"https://www.academia.edu/Documents/in/cyclic_AMP?f_ri=279027","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=279027"},{"id":1342167,"name":"Graves Disease","url":"https://www.academia.edu/Documents/in/Graves_Disease?f_ri=279027"},{"id":1482586,"name":"Autoantibodies","url":"https://www.academia.edu/Documents/in/Autoantibodies?f_ri=279027"},{"id":3004151,"name":"CHO cells","url":"https://www.academia.edu/Documents/in/CHO_cells?f_ri=279027"},{"id":3128226,"name":"Thyroid hormone","url":"https://www.academia.edu/Documents/in/Thyroid_hormone?f_ri=279027"},{"id":3214915,"name":"Cricetinae","url":"https://www.academia.edu/Documents/in/Cricetinae?f_ri=279027"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5510120" data-work_id="5510120" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5510120/Diffusion_tensor_imaging_of_the_normal_prostate_at_3_Tesla">Diffusion tensor imaging of the normal prostate at 3 Tesla</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to assess the feasibility of diffusion tensor imaging (DTI) of the prostate and to determine normative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of healthy prostate with a 3-Tesla... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_5510120" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to assess the feasibility of diffusion tensor imaging (DTI) of the prostate and to determine normative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of healthy prostate with a 3-Tesla magnetic resonance imaging (MRI) system. Thirty volunteers with a mean age of 28 (25–35) years were scanned with a 3-Tesla MRI (Intera Achieva; Philips, The Netherlands) system using a six-channel phased array coil. Initially, T2-weighted turbo spin-echo (TSE) axial images of the prostate were obtained. In two subjects, a millimetric hypointense signal change was detected in the peripheral zones on T2-weighted TSE images. These two subjects were excluded from the study. DTI with single-shot echo-planar imaging (ssEPI) was performed in the remaining 28 subjects. ADC and FA values were measured using the manufacturer supplied software by positioning 9-pixel ROIs on each zone. Differences between parameters of the central and peripheral zones were assessed. Mean ADC value of the central (1.220 ± 0.271 × 10−3 mm2/s) was found to be significantly lower when compared with the peripheral gland (1.610 ± 0.347 × 10−3 mm2/s) (P < 0.01). Mean FA of the central gland was significantly higher (0.26), compared with the peripheral gland (0.16) (P < 0.01). This study shows the feasibility of prostate DTI with a 3-Tesla MR system and the normative FA and ADC values of peripheral and central zones of the normal prostate. The results are compatible with the microstructural organization of the gland.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5510120" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4835faa434c513c56277e672fb6e0014" rel="nofollow" data-download="{"attachment_id":49264122,"asset_id":5510120,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49264122/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="7780265" href="https://khas.academia.edu/ArzuBayram">Arzu Bayram</a><script data-card-contents-for-user="7780265" type="text/json">{"id":7780265,"first_name":"Arzu","last_name":"Bayram","domain_name":"khas","page_name":"ArzuBayram","display_name":"Arzu Bayram","profile_url":"https://khas.academia.edu/ArzuBayram?f_ri=279027","photo":"https://0.academia-photos.com/7780265/3412465/4013442/s65_arzu.bayram.jpg"}</script></span></span></li><li class="js-paper-rank-work_5510120 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="5510120"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 5510120, container: ".js-paper-rank-work_5510120", }); });</script></li><li class="js-percentile-work_5510120 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 5510120; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_5510120"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_5510120 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="5510120"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5510120; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5510120]").text(description); $(".js-view-count-work_5510120").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5510120").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5510120"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="428" rel="nofollow" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" rel="nofollow" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="161553" rel="nofollow" href="https://www.academia.edu/Documents/in/Prostate">Prostate</a>, <script data-card-contents-for-ri="161553" type="text/json">{"id":161553,"name":"Prostate","url":"https://www.academia.edu/Documents/in/Prostate?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="167847" rel="nofollow" href="https://www.academia.edu/Documents/in/Phased_Array">Phased Array</a><script data-card-contents-for-ri="167847" type="text/json">{"id":167847,"name":"Phased Array","url":"https://www.academia.edu/Documents/in/Phased_Array?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5510120]'), work: {"id":5510120,"title":"Diffusion tensor imaging of the normal prostate at 3 Tesla","created_at":"2013-12-23T03:10:26.631-08:00","url":"https://www.academia.edu/5510120/Diffusion_tensor_imaging_of_the_normal_prostate_at_3_Tesla?f_ri=279027","dom_id":"work_5510120","summary":"The aim of this study was to assess the feasibility of diffusion tensor imaging (DTI) of the prostate and to determine normative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of healthy prostate with a 3-Tesla magnetic resonance imaging (MRI) system. Thirty volunteers with a mean age of 28 (25–35) years were scanned with a 3-Tesla MRI (Intera Achieva; Philips, The Netherlands) system using a six-channel phased array coil. Initially, T2-weighted turbo spin-echo (TSE) axial images of the prostate were obtained. In two subjects, a millimetric hypointense signal change was detected in the peripheral zones on T2-weighted TSE images. These two subjects were excluded from the study. DTI with single-shot echo-planar imaging (ssEPI) was performed in the remaining 28 subjects. ADC and FA values were measured using the manufacturer supplied software by positioning 9-pixel ROIs on each zone. Differences between parameters of the central and peripheral zones were assessed. Mean ADC value of the central (1.220 ± 0.271 × 10−3 mm2/s) was found to be significantly lower when compared with the peripheral gland (1.610 ± 0.347 × 10−3 mm2/s) (P \u003c 0.01). Mean FA of the central gland was significantly higher (0.26), compared with the peripheral gland (0.16) (P \u003c 0.01). This study shows the feasibility of prostate DTI with a 3-Tesla MR system and the normative FA and ADC values of peripheral and central zones of the normal prostate. The results are compatible with the microstructural organization of the gland.","downloadable_attachments":[{"id":49264122,"asset_id":5510120,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":7780265,"first_name":"Arzu","last_name":"Bayram","domain_name":"khas","page_name":"ArzuBayram","display_name":"Arzu Bayram","profile_url":"https://khas.academia.edu/ArzuBayram?f_ri=279027","photo":"https://0.academia-photos.com/7780265/3412465/4013442/s65_arzu.bayram.jpg"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=279027","nofollow":true},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=279027","nofollow":true},{"id":161553,"name":"Prostate","url":"https://www.academia.edu/Documents/in/Prostate?f_ri=279027","nofollow":true},{"id":167847,"name":"Phased Array","url":"https://www.academia.edu/Documents/in/Phased_Array?f_ri=279027","nofollow":true},{"id":223788,"name":"Apparent Diffusion Coefficient","url":"https://www.academia.edu/Documents/in/Apparent_Diffusion_Coefficient?f_ri=279027"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":473797,"name":"Microstructures","url":"https://www.academia.edu/Documents/in/Microstructures?f_ri=279027"},{"id":497323,"name":"Fractional Anisotropy","url":"https://www.academia.edu/Documents/in/Fractional_Anisotropy?f_ri=279027"},{"id":2439414,"name":"Magnetic resonance image","url":"https://www.academia.edu/Documents/in/Magnetic_resonance_image?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12227147" data-work_id="12227147" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12227147/An_evolutionary_theory_for_interpreting_urban_scaling_laws">An evolutionary theory for interpreting urban scaling laws</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We try here to illustrate the relevance of an evolutionary theory of urban systems for explaining their hierarchical properties. The largest cities became larger because they were successful in adopting many successive innovations. Larger... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_12227147" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We try here to illustrate the relevance of an evolutionary theory of urban systems for explaining their hierarchical properties. The largest cities became larger because they were successful in adopting many successive innovations. Larger cities capture innovations in a ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/12227147" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d3c3a3aa3729d90dc63ee9998de8098b" rel="nofollow" data-download="{"attachment_id":46293480,"asset_id":12227147,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46293480/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="30720670" href="https://independent.academia.edu/DenisePUMAIN">Denise PUMAIN</a><script data-card-contents-for-user="30720670" type="text/json">{"id":30720670,"first_name":"Denise","last_name":"PUMAIN","domain_name":"independent","page_name":"DenisePUMAIN","display_name":"Denise PUMAIN","profile_url":"https://independent.academia.edu/DenisePUMAIN?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_12227147 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="12227147"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 12227147, container: ".js-paper-rank-work_12227147", }); });</script></li><li class="js-percentile-work_12227147 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12227147; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_12227147"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_12227147 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="12227147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12227147; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12227147]").text(description); $(".js-view-count-work_12227147").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_12227147").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="12227147"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="796326" rel="nofollow" href="https://www.academia.edu/Documents/in/CyberGeo">CyberGeo</a><script data-card-contents-for-ri="796326" type="text/json">{"id":796326,"name":"CyberGeo","url":"https://www.academia.edu/Documents/in/CyberGeo?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=12227147]'), work: {"id":12227147,"title":"An evolutionary theory for interpreting urban scaling laws","created_at":"2015-05-04T08:02:18.266-07:00","url":"https://www.academia.edu/12227147/An_evolutionary_theory_for_interpreting_urban_scaling_laws?f_ri=279027","dom_id":"work_12227147","summary":"We try here to illustrate the relevance of an evolutionary theory of urban systems for explaining their hierarchical properties. The largest cities became larger because they were successful in adopting many successive innovations. Larger cities capture innovations in a ...","downloadable_attachments":[{"id":46293480,"asset_id":12227147,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":30720670,"first_name":"Denise","last_name":"PUMAIN","domain_name":"independent","page_name":"DenisePUMAIN","display_name":"Denise PUMAIN","profile_url":"https://independent.academia.edu/DenisePUMAIN?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":796326,"name":"CyberGeo","url":"https://www.academia.edu/Documents/in/CyberGeo?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_23779588" data-work_id="23779588" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/23779588/Incidence_and_Aetiological_Factors_in_Pilonidal_Sinus_Among_Turkish_Soldiers">Incidence and Aetiological Factors in Pilonidal Sinus Among Turkish Soldiers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To study the incidence and causes of pilonidal sinus in Turkish soldiers. Design: Open study by questionnaire. Setting: Military and University hospitals, Turkey. Subjects: 1000 soldiers who presented for their first medical... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23779588" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To study the incidence and causes of pilonidal sinus in Turkish soldiers. Design: Open study by questionnaire. Setting: Military and University hospitals, Turkey. Subjects: 1000 soldiers who presented for their first medical examination. Main outcome measures: Correlation between factors known to be associated with pilonidal sinus, and incidence of pilonidal sinus. Results: 88/1000 soldiers had pilonidal sinuses; in 48 they were symptomatic and in 40 asymptomatic. The factors associated with the presence of a pilonidal sinus were: family history of pilonidal sinus (18/88 compared with 32/912, p < 0.0001); obesity defined as weight over 90 kg (34/88 compared with 32/912, p < 0.0001); being the driver of a vehicle (58/88 compared with 308/912, p < 0.0001); and the incidence of folliculitis or a furuncle at another site on the body (22/88 compared with 64/912, p < 0.0001). Conclusions: Pilonidal sinus is an acquired condition, penetration of hair is the main cause, and the disease can be prevented if the aetiological factors are understood.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23779588" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2d4086bec37dd79342d34ecf4ccdccff" rel="nofollow" data-download="{"attachment_id":44215578,"asset_id":23779588,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/44215578/download_file?st=MTc0MDE1MjUxOCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33511328" href="https://harran.academia.edu/AliUzunkoy">Ali Uzunkoy</a><script data-card-contents-for-user="33511328" type="text/json">{"id":33511328,"first_name":"Ali","last_name":"Uzunkoy","domain_name":"harran","page_name":"AliUzunkoy","display_name":"Ali Uzunkoy","profile_url":"https://harran.academia.edu/AliUzunkoy?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_23779588 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23779588"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23779588, container: ".js-paper-rank-work_23779588", }); });</script></li><li class="js-percentile-work_23779588 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 23779588; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_23779588"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_23779588 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="23779588"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 23779588; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=23779588]").text(description); $(".js-view-count-work_23779588").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_23779588").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="23779588"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="10966" rel="nofollow" href="https://www.academia.edu/Documents/in/Turkey">Turkey</a>, <script data-card-contents-for-ri="10966" type="text/json">{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="174502" rel="nofollow" href="https://www.academia.edu/Documents/in/Incidence">Incidence</a>, <script data-card-contents-for-ri="174502" type="text/json">{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="1268687" rel="nofollow" href="https://www.academia.edu/Documents/in/Military_Personnel">Military Personnel</a><script data-card-contents-for-ri="1268687" type="text/json">{"id":1268687,"name":"Military Personnel","url":"https://www.academia.edu/Documents/in/Military_Personnel?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=23779588]'), work: {"id":23779588,"title":"Incidence and Aetiological Factors in Pilonidal Sinus Among Turkish Soldiers","created_at":"2016-03-29T19:15:27.345-07:00","url":"https://www.academia.edu/23779588/Incidence_and_Aetiological_Factors_in_Pilonidal_Sinus_Among_Turkish_Soldiers?f_ri=279027","dom_id":"work_23779588","summary":"Objective: To study the incidence and causes of pilonidal sinus in Turkish soldiers. Design: Open study by questionnaire. Setting: Military and University hospitals, Turkey. Subjects: 1000 soldiers who presented for their first medical examination. Main outcome measures: Correlation between factors known to be associated with pilonidal sinus, and incidence of pilonidal sinus. Results: 88/1000 soldiers had pilonidal sinuses; in 48 they were symptomatic and in 40 asymptomatic. The factors associated with the presence of a pilonidal sinus were: family history of pilonidal sinus (18/88 compared with 32/912, p \u003c 0.0001); obesity defined as weight over 90 kg (34/88 compared with 32/912, p \u003c 0.0001); being the driver of a vehicle (58/88 compared with 308/912, p \u003c 0.0001); and the incidence of folliculitis or a furuncle at another site on the body (22/88 compared with 64/912, p \u003c 0.0001). Conclusions: Pilonidal sinus is an acquired condition, penetration of hair is the main cause, and the disease can be prevented if the aetiological factors are understood.","downloadable_attachments":[{"id":44215578,"asset_id":23779588,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33511328,"first_name":"Ali","last_name":"Uzunkoy","domain_name":"harran","page_name":"AliUzunkoy","display_name":"Ali Uzunkoy","profile_url":"https://harran.academia.edu/AliUzunkoy?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey?f_ri=279027","nofollow":true},{"id":174502,"name":"Incidence","url":"https://www.academia.edu/Documents/in/Incidence?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":1268687,"name":"Military Personnel","url":"https://www.academia.edu/Documents/in/Military_Personnel?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14710701" data-work_id="14710701" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14710701/Treatment_of_acute_renal_colic_in_a_French_emergency_department_a_comparison_of_simulated_cases_and_real_cases_in_acute_pain_assessment_and_management">Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: Use of analgesic drugs in acute renal colic varies widely in dierent countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14710701" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: Use of analgesic drugs in acute renal colic varies widely in dierent countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency practitioners. Methods: A sample of 51 emergency practitioners (27 medical doctors and 24 residents) randomly selected in nine EDs in the southwest of France participated in this observational study. In a ®rst step (January 2000), participants were asked about a simulated case of acute renal colic. In a second step, real prescriptions for the same indication were retrospectively identi®ed and collected among hospital medical databases during a period of 6 months (July±December 1999). Results: In simulated cases, non-steroidal anti-in¯ammatory drugs (NSAIDs) were prescribed in 100% of cases, in addition to propacetamol (70%), antispasmodic drugs (53%) and opiate analgesics (100%). Daily dose of these drugs was underestimated in approximately 30% of cases. In real prescription, there was no signi®cant difference in the use of NSAIDs, propacetamol and antispasmodic drugs. However, daily doses were more frequently underestimated, and opiate analgesics were less prescribed. Several points could explain these discrepancies: lack of knowledge about pharmacological properties, inadequate daily review of drug intake, un-derutilisation of opiates and insucient clinical evaluation of pain in several centres. Conclusion: These results show a clear dierence between intention to treat and real prescriptions for patients suffering from acute renal colic.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14710701" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f40b519723db0aaa7ffe9a086fb8aa0d" rel="nofollow" data-download="{"attachment_id":43953605,"asset_id":14710701,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43953605/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32462798" href="https://univ-toulouse.academia.edu/MaryseLapeyremestre">Maryse Lapeyre-mestre</a><script data-card-contents-for-user="32462798" type="text/json">{"id":32462798,"first_name":"Maryse","last_name":"Lapeyre-mestre","domain_name":"univ-toulouse","page_name":"MaryseLapeyremestre","display_name":"Maryse Lapeyre-mestre","profile_url":"https://univ-toulouse.academia.edu/MaryseLapeyremestre?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_14710701 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14710701"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14710701, container: ".js-paper-rank-work_14710701", }); });</script></li><li class="js-percentile-work_14710701 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14710701; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14710701"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14710701 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14710701"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14710701; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14710701]").text(description); $(".js-view-count-work_14710701").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14710701").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14710701"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="8999" rel="nofollow" href="https://www.academia.edu/Documents/in/Kidney_diseases">Kidney diseases</a>, <script data-card-contents-for-ri="8999" type="text/json">{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27336" rel="nofollow" href="https://www.academia.edu/Documents/in/France">France</a>, <script data-card-contents-for-ri="27336" type="text/json">{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="59148" rel="nofollow" href="https://www.academia.edu/Documents/in/Colic">Colic</a>, <script data-card-contents-for-ri="59148" type="text/json">{"id":59148,"name":"Colic","url":"https://www.academia.edu/Documents/in/Colic?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="153168" rel="nofollow" href="https://www.academia.edu/Documents/in/Data_Collection">Data Collection</a><script data-card-contents-for-ri="153168" type="text/json">{"id":153168,"name":"Data Collection","url":"https://www.academia.edu/Documents/in/Data_Collection?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14710701]'), work: {"id":14710701,"title":"Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management","created_at":"2015-08-06T02:46:43.457-07:00","url":"https://www.academia.edu/14710701/Treatment_of_acute_renal_colic_in_a_French_emergency_department_a_comparison_of_simulated_cases_and_real_cases_in_acute_pain_assessment_and_management?f_ri=279027","dom_id":"work_14710701","summary":"Objective: Use of analgesic drugs in acute renal colic varies widely in dierent countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency practitioners. Methods: A sample of 51 emergency practitioners (27 medical doctors and 24 residents) randomly selected in nine EDs in the southwest of France participated in this observational study. In a ®rst step (January 2000), participants were asked about a simulated case of acute renal colic. In a second step, real prescriptions for the same indication were retrospectively identi®ed and collected among hospital medical databases during a period of 6 months (July±December 1999). Results: In simulated cases, non-steroidal anti-in¯ammatory drugs (NSAIDs) were prescribed in 100% of cases, in addition to propacetamol (70%), antispasmodic drugs (53%) and opiate analgesics (100%). Daily dose of these drugs was underestimated in approximately 30% of cases. In real prescription, there was no signi®cant difference in the use of NSAIDs, propacetamol and antispasmodic drugs. However, daily doses were more frequently underestimated, and opiate analgesics were less prescribed. Several points could explain these discrepancies: lack of knowledge about pharmacological properties, inadequate daily review of drug intake, un-derutilisation of opiates and insucient clinical evaluation of pain in several centres. Conclusion: These results show a clear dierence between intention to treat and real prescriptions for patients suffering from acute renal colic.","downloadable_attachments":[{"id":43953605,"asset_id":14710701,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32462798,"first_name":"Maryse","last_name":"Lapeyre-mestre","domain_name":"univ-toulouse","page_name":"MaryseLapeyremestre","display_name":"Maryse Lapeyre-mestre","profile_url":"https://univ-toulouse.academia.edu/MaryseLapeyremestre?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=279027","nofollow":true},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=279027","nofollow":true},{"id":59148,"name":"Colic","url":"https://www.academia.edu/Documents/in/Colic?f_ri=279027","nofollow":true},{"id":153168,"name":"Data Collection","url":"https://www.academia.edu/Documents/in/Data_Collection?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":910024,"name":"Observational Study","url":"https://www.academia.edu/Documents/in/Observational_Study?f_ri=279027"},{"id":1435137,"name":"Emergency Department","url":"https://www.academia.edu/Documents/in/Emergency_Department?f_ri=279027"},{"id":1666741,"name":"Clinical evaluation","url":"https://www.academia.edu/Documents/in/Clinical_evaluation?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14889716" data-work_id="14889716" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14889716/Tissue_distribution_pharmacokinetics_and_identification_of_roscovitine_metabolites_in_rat">Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The pharmacokinetics, biodistribution and the metabolic pathway of roscovitine were investigated in Sprague-Dawley rats after a single intravenous dose of 25 mg/kg. Blood, lungs, kidney, liver, testis, adipose tissue, spleen and brain... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_14889716" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The pharmacokinetics, biodistribution and the metabolic pathway of roscovitine were investigated in Sprague-Dawley rats after a single intravenous dose of 25 mg/kg. Blood, lungs, kidney, liver, testis, adipose tissue, spleen and brain were removed at different time-points. Plasma and tissue samples were analyzed using high performance liquid chromatography. The metabolites were identified using liquid chromatography/tandem mass spectrometry and nuclear magnetic resonance spectroscopy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14889716" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="55616469bb07ec028aec3156dc7d0b4b" rel="nofollow" data-download="{"attachment_id":43803687,"asset_id":14889716,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43803687/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33871430" href="https://ki.academia.edu/MoustaphaHassan">Moustapha Hassan</a><script data-card-contents-for-user="33871430" type="text/json">{"id":33871430,"first_name":"Moustapha","last_name":"Hassan","domain_name":"ki","page_name":"MoustaphaHassan","display_name":"Moustapha Hassan","profile_url":"https://ki.academia.edu/MoustaphaHassan?f_ri=279027","photo":"https://0.academia-photos.com/33871430/10518434/11737500/s65_moustapha.hassan.jpg"}</script></span></span></li><li class="js-paper-rank-work_14889716 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="14889716"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 14889716, container: ".js-paper-rank-work_14889716", }); });</script></li><li class="js-percentile-work_14889716 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14889716; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_14889716"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_14889716 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="14889716"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14889716; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14889716]").text(description); $(".js-view-count-work_14889716").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_14889716").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="14889716"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="5769" rel="nofollow" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="11112" rel="nofollow" href="https://www.academia.edu/Documents/in/Drug_metabolism">Drug metabolism</a>, <script data-card-contents-for-ri="11112" type="text/json">{"id":11112,"name":"Drug metabolism","url":"https://www.academia.edu/Documents/in/Drug_metabolism?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="52489" rel="nofollow" href="https://www.academia.edu/Documents/in/Adipose_tissue">Adipose tissue</a><script data-card-contents-for-ri="52489" type="text/json">{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=14889716]'), work: {"id":14889716,"title":"Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat","created_at":"2015-08-12T23:30:30.808-07:00","url":"https://www.academia.edu/14889716/Tissue_distribution_pharmacokinetics_and_identification_of_roscovitine_metabolites_in_rat?f_ri=279027","dom_id":"work_14889716","summary":"The pharmacokinetics, biodistribution and the metabolic pathway of roscovitine were investigated in Sprague-Dawley rats after a single intravenous dose of 25 mg/kg. Blood, lungs, kidney, liver, testis, adipose tissue, spleen and brain were removed at different time-points. Plasma and tissue samples were analyzed using high performance liquid chromatography. The metabolites were identified using liquid chromatography/tandem mass spectrometry and nuclear magnetic resonance spectroscopy.","downloadable_attachments":[{"id":43803687,"asset_id":14889716,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33871430,"first_name":"Moustapha","last_name":"Hassan","domain_name":"ki","page_name":"MoustaphaHassan","display_name":"Moustapha Hassan","profile_url":"https://ki.academia.edu/MoustaphaHassan?f_ri=279027","photo":"https://0.academia-photos.com/33871430/10518434/11737500/s65_moustapha.hassan.jpg"}],"research_interests":[{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=279027","nofollow":true},{"id":11112,"name":"Drug metabolism","url":"https://www.academia.edu/Documents/in/Drug_metabolism?f_ri=279027","nofollow":true},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=279027","nofollow":true},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue?f_ri=279027","nofollow":true},{"id":75847,"name":"HPLC","url":"https://www.academia.edu/Documents/in/HPLC?f_ri=279027"},{"id":114941,"name":"Nmr","url":"https://www.academia.edu/Documents/in/Nmr?f_ri=279027"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry?f_ri=279027"},{"id":225787,"name":"High Performance Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Performance_Liquid_Chromatography?f_ri=279027"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=279027"},{"id":398287,"name":"Liquid Chromatography","url":"https://www.academia.edu/Documents/in/Liquid_Chromatography?f_ri=279027"},{"id":764799,"name":"Metabolic pathway","url":"https://www.academia.edu/Documents/in/Metabolic_pathway?f_ri=279027"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve?f_ri=279027"},{"id":1911537,"name":"Nuclear Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Nuclear_Magnetic_Resonance_Spectroscopy?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_22765973" data-work_id="22765973" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/22765973/The_role_of_FDG_PET_CT_in_the_detection_of_recurrent_colorectal_cancer">The role of FDG-PET/CT in the detection of recurrent colorectal cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose: The conventional diagnostic techniques used to assess recurrence of colorectal cancer (CRCR) often yield unspecific findings. Integrated FDG-PET/CT seems to offer promise for the differential diagnosis of benign and malignant... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_22765973" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose: The conventional diagnostic techniques used to assess recurrence of colorectal cancer (CRCR) often yield unspecific findings. Integrated FDG-PET/CT seems to offer promise for the differential diagnosis of benign and malignant lesions. The aim of this study was to compare the value of FDG-PET and PET/ CT in the detection of CRCR subsequent to colonic resection or rectal amputation. Methods: The population for this retrospective study comprised 84 patients with suspected CRCR. The sensitivity, specificity and accuracy of PET and PET/CT were calculated for (a) intra-abdominal extrahepatic recurrences, (b) extra-abdominal and/or hepatic recurrences and (c) all recurrences, and tumour marker levels were analysed. Results: The sensitivity, specificity and overall accuracy of PET in detecting intra-abdominal extrahepatic CRCR were 82%, 88% and 86%, respectively, compared with 88%, 94% and 92%, respectively, for PET/CT. The corresponding figures for detection of extra-abdominal and/or hepatic CRCR were 74%, 88% and 85% for PET and 95%, 100% and 99% for PET/CT. Considering the entire population, the sensitivity, specificity and overall accuracy of PET were 80%, 69% and 75%, respectively, compared with 89%, 92% and 90%, respectively, for PET/CT. FDG-PET/CT examination correctly detected 40 out of a total of 45 patients with CRCR. Two of five patients with falsely negative FDG-PET/CT findings had local microscopic recurrences and one had miliary liver metastases. Of 39 patients without CRCR, three showed false positive FDG-PET/CT results. Two of these cases were due to increased accumulation in inflammatory foci in the bowel wall, while one was due to haemorrhaging into the adrenal gland. Conclusion: FDG-PET/CT appears to be a very promising method for distinguishing a viable tumour from fibrous changes, thereby avoiding unnecessary laparotomy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/22765973" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e17375778e58684f76647d93251c9bc4" rel="nofollow" data-download="{"attachment_id":43323753,"asset_id":22765973,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43323753/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44402357" href="https://independent.academia.edu/RadkaLohynska">Radka Lohynska</a><script data-card-contents-for-user="44402357" type="text/json">{"id":44402357,"first_name":"Radka","last_name":"Lohynska","domain_name":"independent","page_name":"RadkaLohynska","display_name":"Radka Lohynska","profile_url":"https://independent.academia.edu/RadkaLohynska?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_22765973 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="22765973"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 22765973, container: ".js-paper-rank-work_22765973", }); });</script></li><li class="js-percentile-work_22765973 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22765973; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_22765973"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_22765973 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="22765973"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22765973; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22765973]").text(description); $(".js-view-count-work_22765973").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_22765973").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="22765973"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="23518" rel="nofollow" href="https://www.academia.edu/Documents/in/Positron_Emission_Tomography">Positron Emission Tomography</a>, <script data-card-contents-for-ri="23518" type="text/json">{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37292" rel="nofollow" href="https://www.academia.edu/Documents/in/Colorectal_cancer">Colorectal cancer</a>, <script data-card-contents-for-ri="37292" type="text/json">{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="162159" rel="nofollow" href="https://www.academia.edu/Documents/in/Differential_Diagnosis">Differential Diagnosis</a>, <script data-card-contents-for-ri="162159" type="text/json">{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22765973]'), work: {"id":22765973,"title":"The role of FDG-PET/CT in the detection of recurrent colorectal cancer","created_at":"2016-03-03T11:49:55.233-08:00","url":"https://www.academia.edu/22765973/The_role_of_FDG_PET_CT_in_the_detection_of_recurrent_colorectal_cancer?f_ri=279027","dom_id":"work_22765973","summary":"Purpose: The conventional diagnostic techniques used to assess recurrence of colorectal cancer (CRCR) often yield unspecific findings. Integrated FDG-PET/CT seems to offer promise for the differential diagnosis of benign and malignant lesions. The aim of this study was to compare the value of FDG-PET and PET/ CT in the detection of CRCR subsequent to colonic resection or rectal amputation. Methods: The population for this retrospective study comprised 84 patients with suspected CRCR. The sensitivity, specificity and accuracy of PET and PET/CT were calculated for (a) intra-abdominal extrahepatic recurrences, (b) extra-abdominal and/or hepatic recurrences and (c) all recurrences, and tumour marker levels were analysed. Results: The sensitivity, specificity and overall accuracy of PET in detecting intra-abdominal extrahepatic CRCR were 82%, 88% and 86%, respectively, compared with 88%, 94% and 92%, respectively, for PET/CT. The corresponding figures for detection of extra-abdominal and/or hepatic CRCR were 74%, 88% and 85% for PET and 95%, 100% and 99% for PET/CT. Considering the entire population, the sensitivity, specificity and overall accuracy of PET were 80%, 69% and 75%, respectively, compared with 89%, 92% and 90%, respectively, for PET/CT. FDG-PET/CT examination correctly detected 40 out of a total of 45 patients with CRCR. Two of five patients with falsely negative FDG-PET/CT findings had local microscopic recurrences and one had miliary liver metastases. Of 39 patients without CRCR, three showed false positive FDG-PET/CT results. Two of these cases were due to increased accumulation in inflammatory foci in the bowel wall, while one was due to haemorrhaging into the adrenal gland. Conclusion: FDG-PET/CT appears to be a very promising method for distinguishing a viable tumour from fibrous changes, thereby avoiding unnecessary laparotomy.","downloadable_attachments":[{"id":43323753,"asset_id":22765973,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44402357,"first_name":"Radka","last_name":"Lohynska","domain_name":"independent","page_name":"RadkaLohynska","display_name":"Radka Lohynska","profile_url":"https://independent.academia.edu/RadkaLohynska?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":23518,"name":"Positron Emission Tomography","url":"https://www.academia.edu/Documents/in/Positron_Emission_Tomography?f_ri=279027","nofollow":true},{"id":37292,"name":"Colorectal cancer","url":"https://www.academia.edu/Documents/in/Colorectal_cancer?f_ri=279027","nofollow":true},{"id":162159,"name":"Differential Diagnosis","url":"https://www.academia.edu/Documents/in/Differential_Diagnosis?f_ri=279027","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=279027"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=279027"},{"id":589853,"name":"Adrenal Gland","url":"https://www.academia.edu/Documents/in/Adrenal_Gland?f_ri=279027"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=279027"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=279027"},{"id":990198,"name":"Retrospective Study","url":"https://www.academia.edu/Documents/in/Retrospective_Study?f_ri=279027"},{"id":2005029,"name":"False Negative","url":"https://www.academia.edu/Documents/in/False_Negative?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15714708" data-work_id="15714708" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15714708/Self_reported_physical_activity_behaviour_exercise_motivation_and_information_among_Danish_adult_cancer_patients_undergoing_chemotherapy">Self-reported physical activity behaviour; exercise motivation and information among Danish adult cancer patients undergoing chemotherapy</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Physical activity is considered an important and determining factor for the cancer patient&#39;s physical well-being and quality of life. However, cancer treatment may disrupt the practice of physical activity, and the prevention of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15714708" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Physical activity is considered an important and determining factor for the cancer patient&#39;s physical well-being and quality of life. However, cancer treatment may disrupt the practice of physical activity, and the prevention of sedentary lifestyles in cancer survivors is imperative. The current study aimed at investigating self-reported physical activity behaviour, exercise motivation and information in cancer patients undergoing chemotherapy. Using a cross-sectional design, 451 patients (18-65 years) completed a questionnaire assessing pre-illness and present physical activity; motivation and information received. Patients reported a significant decline in physical activity from pre-illness to the time in active treatment (p&lt;0.001). Amongst the respondents, 68% answered that they believed exercise to be beneficial; and 78% claimed not exercising as much as desired. Exercise barriers included fatigue (74%) and physical discomfort (45%). Present physical activity behaviour wa...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15714708" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4729548c5d83f10024e9fcc9658af3c4" rel="nofollow" data-download="{"attachment_id":41203117,"asset_id":15714708,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41203117/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34904476" href="https://independent.academia.edu/MortenQuist">Morten Quist</a><script data-card-contents-for-user="34904476" type="text/json">{"id":34904476,"first_name":"Morten","last_name":"Quist","domain_name":"independent","page_name":"MortenQuist","display_name":"Morten Quist","profile_url":"https://independent.academia.edu/MortenQuist?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15714708 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15714708"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15714708, container: ".js-paper-rank-work_15714708", }); });</script></li><li class="js-percentile-work_15714708 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 15714708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_15714708"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_15714708 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="15714708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 15714708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=15714708]").text(description); $(".js-view-count-work_15714708").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15714708").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15714708"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="588" rel="nofollow" href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9112" rel="nofollow" href="https://www.academia.edu/Documents/in/Physical_Activity">Physical Activity</a>, <script data-card-contents-for-ri="9112" type="text/json">{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15714708]'), work: {"id":15714708,"title":"Self-reported physical activity behaviour; exercise motivation and information among Danish adult cancer patients undergoing chemotherapy","created_at":"2015-09-15T02:22:34.239-07:00","url":"https://www.academia.edu/15714708/Self_reported_physical_activity_behaviour_exercise_motivation_and_information_among_Danish_adult_cancer_patients_undergoing_chemotherapy?f_ri=279027","dom_id":"work_15714708","summary":"Physical activity is considered an important and determining factor for the cancer patient\u0026#39;s physical well-being and quality of life. However, cancer treatment may disrupt the practice of physical activity, and the prevention of sedentary lifestyles in cancer survivors is imperative. The current study aimed at investigating self-reported physical activity behaviour, exercise motivation and information in cancer patients undergoing chemotherapy. Using a cross-sectional design, 451 patients (18-65 years) completed a questionnaire assessing pre-illness and present physical activity; motivation and information received. Patients reported a significant decline in physical activity from pre-illness to the time in active treatment (p\u0026lt;0.001). Amongst the respondents, 68% answered that they believed exercise to be beneficial; and 78% claimed not exercising as much as desired. Exercise barriers included fatigue (74%) and physical discomfort (45%). Present physical activity behaviour wa...","downloadable_attachments":[{"id":41203117,"asset_id":15714708,"asset_type":"Work","always_allow_download":false},{"id":41203106,"asset_id":15714708,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34904476,"first_name":"Morten","last_name":"Quist","domain_name":"independent","page_name":"MortenQuist","display_name":"Morten Quist","profile_url":"https://independent.academia.edu/MortenQuist?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=279027","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true},{"id":9112,"name":"Physical Activity","url":"https://www.academia.edu/Documents/in/Physical_Activity?f_ri=279027","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true},{"id":29423,"name":"Cancer treatment","url":"https://www.academia.edu/Documents/in/Cancer_treatment?f_ri=279027"},{"id":46406,"name":"Motivation","url":"https://www.academia.edu/Documents/in/Motivation?f_ri=279027"},{"id":54085,"name":"Denmark","url":"https://www.academia.edu/Documents/in/Denmark?f_ri=279027"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=279027"},{"id":163353,"name":"Cancer Chemotherapy","url":"https://www.academia.edu/Documents/in/Cancer_Chemotherapy?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=279027"},{"id":404000,"name":"Cross Section","url":"https://www.academia.edu/Documents/in/Cross_Section?f_ri=279027"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=279027"},{"id":514824,"name":"Cancer Survivor","url":"https://www.academia.edu/Documents/in/Cancer_Survivor?f_ri=279027"},{"id":532278,"name":"Cancer Patient","url":"https://www.academia.edu/Documents/in/Cancer_Patient?f_ri=279027"},{"id":584601,"name":"Chi Square Distribution","url":"https://www.academia.edu/Documents/in/Chi_Square_Distribution?f_ri=279027"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=279027"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models?f_ri=279027"},{"id":1795787,"name":"Leisure Activities","url":"https://www.academia.edu/Documents/in/Leisure_Activities?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21649685" data-work_id="21649685" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21649685/Immunological_rejection_of_heart_transplant_how_lytic_granules_from_cytotoxic_T_lymphocytes_damage_guinea_pig_ventricular_myocytes">Immunological rejection of heart transplant: how lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">We investigated the mechanism by which lytic granules extracted from cytotoxic T lymphocytes (CTL) damage guinea pig ventricular myocytes in order to dertermine whether their actions can be related to the overall immunological rejection... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21649685" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">We investigated the mechanism by which lytic granules extracted from cytotoxic T lymphocytes (CTL) damage guinea pig ventricular myocytes in order to dertermine whether their actions can be related to the overall immunological rejection of the transplanted heart. Granule-induced myocyte morphological changes and final destruction were preceded by shortening of action potential duration (APD) and reductions of the resting potential and the action potential amplitude. APD shortening was probably caused by a granule-induced increase in outward current (most likely non-specific). Ryanodine, which blocks Ca 2+ release from the sacroplasmic reticulum, did not interfere with the morphological and electrophysiological effects of lytic granules. Fura-2 imaging indicated that [caa+] i initially increased about 2-fold from 90.0_ll.5nM, while cell length decreased less than 5% from a mean value of 99.0+_9.0 I-tm. A further increase in [Ca2+] i (> 10 fold) was associated with progressive contracture and destruction, suggesting that the structural damage inflicted by lytic granules is caused by [Ca2+] i overload. The results indicate that the cytocidal action of CTL-derived lyric granules may be involved in immunologically induced damage, even to the extent of rejection of the transplanted heart.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21649685" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ee0b193032389d39b8f92af3648bacc7" rel="nofollow" data-download="{"attachment_id":42283475,"asset_id":21649685,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42283475/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42796521" href="https://weizmann.academia.edu/GideonBerke">Gideon Berke</a><script data-card-contents-for-user="42796521" type="text/json">{"id":42796521,"first_name":"Gideon","last_name":"Berke","domain_name":"weizmann","page_name":"GideonBerke","display_name":"Gideon Berke","profile_url":"https://weizmann.academia.edu/GideonBerke?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21649685 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21649685"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21649685, container: ".js-paper-rank-work_21649685", }); });</script></li><li class="js-percentile-work_21649685 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21649685; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21649685"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21649685 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21649685"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21649685; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21649685]").text(description); $(".js-view-count-work_21649685").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21649685").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21649685"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="167" rel="nofollow" href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="186234" rel="nofollow" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a>, <script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="392828" rel="nofollow" href="https://www.academia.edu/Documents/in/Myocardium">Myocardium</a><script data-card-contents-for-ri="392828" type="text/json">{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21649685]'), work: {"id":21649685,"title":"Immunological rejection of heart transplant: how lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes","created_at":"2016-02-07T02:59:01.921-08:00","url":"https://www.academia.edu/21649685/Immunological_rejection_of_heart_transplant_how_lytic_granules_from_cytotoxic_T_lymphocytes_damage_guinea_pig_ventricular_myocytes?f_ri=279027","dom_id":"work_21649685","summary":"We investigated the mechanism by which lytic granules extracted from cytotoxic T lymphocytes (CTL) damage guinea pig ventricular myocytes in order to dertermine whether their actions can be related to the overall immunological rejection of the transplanted heart. Granule-induced myocyte morphological changes and final destruction were preceded by shortening of action potential duration (APD) and reductions of the resting potential and the action potential amplitude. APD shortening was probably caused by a granule-induced increase in outward current (most likely non-specific). Ryanodine, which blocks Ca 2+ release from the sacroplasmic reticulum, did not interfere with the morphological and electrophysiological effects of lytic granules. Fura-2 imaging indicated that [caa+] i initially increased about 2-fold from 90.0_ll.5nM, while cell length decreased less than 5% from a mean value of 99.0+_9.0 I-tm. A further increase in [Ca2+] i (\u003e 10 fold) was associated with progressive contracture and destruction, suggesting that the structural damage inflicted by lytic granules is caused by [Ca2+] i overload. The results indicate that the cytocidal action of CTL-derived lyric granules may be involved in immunologically induced damage, even to the extent of rejection of the transplanted heart.","downloadable_attachments":[{"id":42283475,"asset_id":21649685,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42796521,"first_name":"Gideon","last_name":"Berke","domain_name":"weizmann","page_name":"GideonBerke","display_name":"Gideon Berke","profile_url":"https://weizmann.academia.edu/GideonBerke?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=279027","nofollow":true},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":392828,"name":"Myocardium","url":"https://www.academia.edu/Documents/in/Myocardium?f_ri=279027","nofollow":true},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig?f_ri=279027"},{"id":666669,"name":"Action potential","url":"https://www.academia.edu/Documents/in/Action_potential?f_ri=279027"},{"id":893785,"name":"Graft Rejection","url":"https://www.academia.edu/Documents/in/Graft_Rejection?f_ri=279027"},{"id":955727,"name":"Action Potentials","url":"https://www.academia.edu/Documents/in/Action_Potentials?f_ri=279027"},{"id":987931,"name":"Heart Transplantation","url":"https://www.academia.edu/Documents/in/Heart_Transplantation?f_ri=279027"},{"id":1154249,"name":"Heart Ventricles","url":"https://www.academia.edu/Documents/in/Heart_Ventricles?f_ri=279027"},{"id":1320031,"name":"Action Potential Duration","url":"https://www.academia.edu/Documents/in/Action_Potential_Duration?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19323769" data-work_id="19323769" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19323769/Evidence_that_TRPC1_contributes_to_calcium_induced_differentiation_of_human_keratinocytes">Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">External calcium ion concentration is a major regulator of epidermal keratinocyte differentiation in vitro and probably also in vivo. Regulation of calcium-induced differentiation changes is proposed to occur via an external... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_19323769" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">External calcium ion concentration is a major regulator of epidermal keratinocyte differentiation in vitro and probably also in vivo. Regulation of calcium-induced differentiation changes is proposed to occur via an external calcium-sensing, signaling pathway that utilizes increases in intracellular calcium ion concentration to activate differentiation-related gene expression. Calcium ion release from intracellular stores and calcium ion influx via storeoperated calcium-permeable channels are key elements in this proposed signaling pathway; however, the channels involved have not yet been identified. The present report shows that human gingival keratinocytes (HGKs) also undergo calcium-induced differentiation in vitro as indicated by involucrin expression and morphological changes. Moreover, TRPC1, which functions as a store-operated calcium channel in a number of cell types, including epidermal keratinocytes, is expressed in both proliferating and differentiating HGKs. Transfection of HGKs with TRPC1 siRNA disrupted expression of TRPC1 mRNA and protein com-pared with transfection with scrambled TRPC1 siRNA. Cells with disrupted TRPC1 expression showed decreased calcium-induced differentiation as measured by involucrin expression or morphological changes, as well as decreased thapsigargin-induced calcium ion influx, and a decreased rate of store calcium release. These results indicate that TRPC1 is involved in calcium-induced differentiation of HGKs likely by supporting a store-operated calcium ion influx.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19323769" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="bded0b60947df19842b9e32d1b04fa15" rel="nofollow" data-download="{"attachment_id":40556272,"asset_id":19323769,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40556272/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39578568" href="https://washington.academia.edu/RichardPresland">Richard Presland</a><script data-card-contents-for-user="39578568" type="text/json">{"id":39578568,"first_name":"Richard","last_name":"Presland","domain_name":"washington","page_name":"RichardPresland","display_name":"Richard Presland","profile_url":"https://washington.academia.edu/RichardPresland?f_ri=279027","photo":"https://0.academia-photos.com/39578568/12757414/14188918/s65_richard.presland.jpg"}</script></span></span></li><li class="js-paper-rank-work_19323769 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="19323769"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 19323769, container: ".js-paper-rank-work_19323769", }); });</script></li><li class="js-percentile-work_19323769 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19323769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_19323769"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_19323769 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="19323769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19323769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19323769]").text(description); $(".js-view-count-work_19323769").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_19323769").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="19323769"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="167" rel="nofollow" href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" rel="nofollow" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27784" rel="nofollow" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a>, <script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="51121" rel="nofollow" href="https://www.academia.edu/Documents/in/RNA_interference">RNA interference</a><script data-card-contents-for-ri="51121" type="text/json">{"id":51121,"name":"RNA interference","url":"https://www.academia.edu/Documents/in/RNA_interference?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=19323769]'), work: {"id":19323769,"title":"Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes","created_at":"2015-12-01T15:07:00.725-08:00","url":"https://www.academia.edu/19323769/Evidence_that_TRPC1_contributes_to_calcium_induced_differentiation_of_human_keratinocytes?f_ri=279027","dom_id":"work_19323769","summary":"External calcium ion concentration is a major regulator of epidermal keratinocyte differentiation in vitro and probably also in vivo. Regulation of calcium-induced differentiation changes is proposed to occur via an external calcium-sensing, signaling pathway that utilizes increases in intracellular calcium ion concentration to activate differentiation-related gene expression. Calcium ion release from intracellular stores and calcium ion influx via storeoperated calcium-permeable channels are key elements in this proposed signaling pathway; however, the channels involved have not yet been identified. The present report shows that human gingival keratinocytes (HGKs) also undergo calcium-induced differentiation in vitro as indicated by involucrin expression and morphological changes. Moreover, TRPC1, which functions as a store-operated calcium channel in a number of cell types, including epidermal keratinocytes, is expressed in both proliferating and differentiating HGKs. Transfection of HGKs with TRPC1 siRNA disrupted expression of TRPC1 mRNA and protein com-pared with transfection with scrambled TRPC1 siRNA. Cells with disrupted TRPC1 expression showed decreased calcium-induced differentiation as measured by involucrin expression or morphological changes, as well as decreased thapsigargin-induced calcium ion influx, and a decreased rate of store calcium release. These results indicate that TRPC1 is involved in calcium-induced differentiation of HGKs likely by supporting a store-operated calcium ion influx.","downloadable_attachments":[{"id":40556272,"asset_id":19323769,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39578568,"first_name":"Richard","last_name":"Presland","domain_name":"washington","page_name":"RichardPresland","display_name":"Richard Presland","profile_url":"https://washington.academia.edu/RichardPresland?f_ri=279027","photo":"https://0.academia-photos.com/39578568/12757414/14188918/s65_richard.presland.jpg"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=279027","nofollow":true},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=279027","nofollow":true},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=279027","nofollow":true},{"id":51121,"name":"RNA interference","url":"https://www.academia.edu/Documents/in/RNA_interference?f_ri=279027","nofollow":true},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=279027"},{"id":70552,"name":"Keratinocytes","url":"https://www.academia.edu/Documents/in/Keratinocytes?f_ri=279027"},{"id":140122,"name":"Calcium Channel","url":"https://www.academia.edu/Documents/in/Calcium_Channel?f_ri=279027"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=279027"},{"id":1823382,"name":"Intracellular Calcium","url":"https://www.academia.edu/Documents/in/Intracellular_Calcium?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16830676" data-work_id="16830676" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16830676/Correlation_between_the_Stoichiometry_and_the_Bistability_of_Electronic_States_in_Valence_Tautomeric_RbxMn_Fe_CN_6_y_zH2O_Complexes">Correlation between the Stoichiometry and the Bistability of Electronic States in Valence-Tautomeric RbxMn[Fe(CN)6]y·zH2O Complexes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A series of Prussian blue analogues, Rb x Mn[Fe(CN) 6 ] y ·zH 2 O with different stoichiometries have been synthesized. Elemental analyses reveal a quasilinear decrease in x and y when z increases. Some of these samples present a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16830676" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A series of Prussian blue analogues, Rb x Mn[Fe(CN) 6 ] y ·zH 2 O with different stoichiometries have been synthesized. Elemental analyses reveal a quasilinear decrease in x and y when z increases. Some of these samples present a first-order phase transition between the Mn II -Fe III and Mn III -Fe II electronic states with large thermal hysteresis loops observed in the magnetic susceptibility. The phase-transition temperatures correlate with the stoichiometry, but quantitative predictions cannot be made because of the disordered nature of the compounds. Contrary to previous literature reports, [a]</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16830676" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1f3ceea67098d8a6fc90a55d22ff0eaf" rel="nofollow" data-download="{"attachment_id":39205930,"asset_id":16830676,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39205930/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36281437" href="https://metaaprendizaje.academia.edu/RaquelFernandez">Raquel Fernandez</a><script data-card-contents-for-user="36281437" type="text/json">{"id":36281437,"first_name":"Raquel","last_name":"Fernandez","domain_name":"metaaprendizaje","page_name":"RaquelFernandez","display_name":"Raquel Fernandez","profile_url":"https://metaaprendizaje.academia.edu/RaquelFernandez?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16830676 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16830676"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16830676, container: ".js-paper-rank-work_16830676", }); });</script></li><li class="js-percentile-work_16830676 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16830676; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16830676"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16830676 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16830676"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16830676; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16830676]").text(description); $(".js-view-count-work_16830676").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16830676").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16830676"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="530" rel="nofollow" href="https://www.academia.edu/Documents/in/Inorganic_Chemistry">Inorganic Chemistry</a>, <script data-card-contents-for-ri="530" type="text/json">{"id":530,"name":"Inorganic Chemistry","url":"https://www.academia.edu/Documents/in/Inorganic_Chemistry?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="116193" rel="nofollow" href="https://www.academia.edu/Documents/in/Solid_State_electronic_devices">Solid State electronic devices</a>, <script data-card-contents-for-ri="116193" type="text/json">{"id":116193,"name":"Solid State electronic devices","url":"https://www.academia.edu/Documents/in/Solid_State_electronic_devices?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16830676]'), work: {"id":16830676,"title":"Correlation between the Stoichiometry and the Bistability of Electronic States in Valence-Tautomeric RbxMn[Fe(CN)6]y·zH2O Complexes","created_at":"2015-10-15T06:35:28.220-07:00","url":"https://www.academia.edu/16830676/Correlation_between_the_Stoichiometry_and_the_Bistability_of_Electronic_States_in_Valence_Tautomeric_RbxMn_Fe_CN_6_y_zH2O_Complexes?f_ri=279027","dom_id":"work_16830676","summary":"A series of Prussian blue analogues, Rb x Mn[Fe(CN) 6 ] y ·zH 2 O with different stoichiometries have been synthesized. Elemental analyses reveal a quasilinear decrease in x and y when z increases. Some of these samples present a first-order phase transition between the Mn II -Fe III and Mn III -Fe II electronic states with large thermal hysteresis loops observed in the magnetic susceptibility. The phase-transition temperatures correlate with the stoichiometry, but quantitative predictions cannot be made because of the disordered nature of the compounds. Contrary to previous literature reports, [a]","downloadable_attachments":[{"id":39205930,"asset_id":16830676,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36281437,"first_name":"Raquel","last_name":"Fernandez","domain_name":"metaaprendizaje","page_name":"RaquelFernandez","display_name":"Raquel Fernandez","profile_url":"https://metaaprendizaje.academia.edu/RaquelFernandez?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":530,"name":"Inorganic Chemistry","url":"https://www.academia.edu/Documents/in/Inorganic_Chemistry?f_ri=279027","nofollow":true},{"id":116193,"name":"Solid State electronic devices","url":"https://www.academia.edu/Documents/in/Solid_State_electronic_devices?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_76203101" data-work_id="76203101" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/76203101/Early_Childhood_Caries_ECC_whats_in_a_name">Early Childhood Caries (ECC): what's in a name?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">It is evident from the number of published scientific papers on Early Childhood Caries (ECC) that interest in this problem has grown in recent years. Many authors have been trying to devise a clear definition or classification for ECC.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_76203101" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">It is evident from the number of published scientific papers on Early Childhood Caries (ECC) that interest in this problem has grown in recent years. Many authors have been trying to devise a clear definition or classification for ECC. The aim of this review was to inventory the prevalence of ECC and to seek a consensus regarding definition and diagnosis. Further attention was paid to the aetiological factors including the role of microrganisms. Finally, education, parenting and treatment procedures were discussed. For this review, epidemiological studies on caries prevalence in children aged between 0 and 36 months were compiled through a systematic approach using Medline. This clearly showed that ECC continues to be a serious public health problem and that there is a great variety of definitions and diagnoses used worldwide, reflected in the prevalence data. This review confirms the multicausal aetiology and the need for further research. The authors strongly support the recommend...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/76203101" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dafd3c02e0c24af67628bf8967e963a7" rel="nofollow" data-download="{"attachment_id":83959290,"asset_id":76203101,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83959290/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="197559010" href="https://independent.academia.edu/JohanAps">Johan Aps</a><script data-card-contents-for-user="197559010" type="text/json">{"id":197559010,"first_name":"Johan","last_name":"Aps","domain_name":"independent","page_name":"JohanAps","display_name":"Johan Aps","profile_url":"https://independent.academia.edu/JohanAps?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_76203101 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="76203101"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 76203101, container: ".js-paper-rank-work_76203101", }); });</script></li><li class="js-percentile-work_76203101 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 76203101; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_76203101"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_76203101 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="76203101"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 76203101; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=76203101]").text(description); $(".js-view-count-work_76203101").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_76203101").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="76203101"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="596" rel="nofollow" href="https://www.academia.edu/Documents/in/Dentistry">Dentistry</a>, <script data-card-contents-for-ri="596" type="text/json">{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="8348" rel="nofollow" href="https://www.academia.edu/Documents/in/Library_and_Information_Science">Library and Information Science</a>, <script data-card-contents-for-ri="8348" type="text/json">{"id":8348,"name":"Library and Information Science","url":"https://www.academia.edu/Documents/in/Library_and_Information_Science?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=76203101]'), work: {"id":76203101,"title":"Early Childhood Caries (ECC): what's in a name?","created_at":"2022-04-12T02:15:54.821-07:00","url":"https://www.academia.edu/76203101/Early_Childhood_Caries_ECC_whats_in_a_name?f_ri=279027","dom_id":"work_76203101","summary":"It is evident from the number of published scientific papers on Early Childhood Caries (ECC) that interest in this problem has grown in recent years. Many authors have been trying to devise a clear definition or classification for ECC. The aim of this review was to inventory the prevalence of ECC and to seek a consensus regarding definition and diagnosis. Further attention was paid to the aetiological factors including the role of microrganisms. Finally, education, parenting and treatment procedures were discussed. For this review, epidemiological studies on caries prevalence in children aged between 0 and 36 months were compiled through a systematic approach using Medline. This clearly showed that ECC continues to be a serious public health problem and that there is a great variety of definitions and diagnoses used worldwide, reflected in the prevalence data. This review confirms the multicausal aetiology and the need for further research. The authors strongly support the recommend...","downloadable_attachments":[{"id":83959290,"asset_id":76203101,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":197559010,"first_name":"Johan","last_name":"Aps","domain_name":"independent","page_name":"JohanAps","display_name":"Johan Aps","profile_url":"https://independent.academia.edu/JohanAps?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":596,"name":"Dentistry","url":"https://www.academia.edu/Documents/in/Dentistry?f_ri=279027","nofollow":true},{"id":8348,"name":"Library and Information Science","url":"https://www.academia.edu/Documents/in/Library_and_Information_Science?f_ri=279027","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true},{"id":105826,"name":"Dental Caries","url":"https://www.academia.edu/Documents/in/Dental_Caries?f_ri=279027"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=279027"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=279027"},{"id":419881,"name":"Oral Hygiene","url":"https://www.academia.edu/Documents/in/Oral_Hygiene?f_ri=279027"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75025188" data-work_id="75025188" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75025188/Fine_mapping_of_a_QTL_on_chromosome_13_for_submaximal_exercise_capacity_training_response_the_HERITAGE_Family_Study">Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Although regular exercise improves submaximal aerobic capacity, there is large variability in its response to exercise training. While this variation is thought to be partly due to genetic differences, relatively little is known about the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75025188" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Although regular exercise improves submaximal aerobic capacity, there is large variability in its response to exercise training. While this variation is thought to be partly due to genetic differences, relatively little is known about the causal genes. Submaximal aerobic capacity traits in the current report include the responses of oxygen consumption (ΔVO 2 60), power output (ΔWORK60), and cardiac output (ΔQ60) at 60% of VO 2 max to a standardized 20-week endurance exercise training program. Genome-wide linkage analysis in 475 HERITAGE Family Study Caucasians identified a locus on chromosome 13q for ΔVO 2 60 (LOD = 3.11). Follow-up fine mapping involved a dense marker panel of over 1,800 single-nucleotide polymorphisms (SNPs) in a 7.9-Mb region (21.1-29.1 Mb from p-terminus). Single-SNP analyses found 14 SNPs moderately associated with both ΔVO 2 60 at P ≤ 0.005 and the correlated traits of ΔWORK60 and ΔQ60 at P < 0.05. Haplotype analyses provided several strong signals (P<1.0 × 10 -5 ) for ΔVO 2 60. Overall, association analyses narrowed the target region and included potential biological candidate genes (MIPEP and SGCG). Consistent with maximal heritability estimates of 23%, up to 20% of the phenotypic variance in ΔVO 2 60 was accounted for by these SNPs. These results implicate candidate genes on chromosome 13q12 for the ability to improve submaximal exercise capacity in response to regular exercise. Submaximal exercise at 60% of maximal capacity is an exercise intensity that falls well within the range recommended in the Physical Activity Guidelines for Americans and thus has potential public health relevance.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75025188" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ac72268afe2daa2075213647da2e06b6" rel="nofollow" data-download="{"attachment_id":82962464,"asset_id":75025188,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82962464/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="219370942" href="https://independent.academia.edu/MargaritaTeran6">Margarita Teran</a><script data-card-contents-for-user="219370942" type="text/json">{"id":219370942,"first_name":"Margarita","last_name":"Teran","domain_name":"independent","page_name":"MargaritaTeran6","display_name":"Margarita Teran","profile_url":"https://independent.academia.edu/MargaritaTeran6?f_ri=279027","photo":"https://0.academia-photos.com/219370942/112435653/101698865/s65_margarita.teran.png"}</script></span></span></li><li class="js-paper-rank-work_75025188 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75025188"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75025188, container: ".js-paper-rank-work_75025188", }); });</script></li><li class="js-percentile-work_75025188 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75025188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_75025188"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_75025188 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="75025188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75025188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75025188]").text(description); $(".js-view-count-work_75025188").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75025188").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75025188"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="7710" rel="nofollow" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="42324" rel="nofollow" href="https://www.academia.edu/Documents/in/Heredity">Heredity</a>, <script data-card-contents-for-ri="42324" type="text/json">{"id":42324,"name":"Heredity","url":"https://www.academia.edu/Documents/in/Heredity?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="86952" rel="nofollow" href="https://www.academia.edu/Documents/in/Haplotypes">Haplotypes</a><script data-card-contents-for-ri="86952" type="text/json">{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75025188]'), work: {"id":75025188,"title":"Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study","created_at":"2022-03-30T21:23:35.682-07:00","url":"https://www.academia.edu/75025188/Fine_mapping_of_a_QTL_on_chromosome_13_for_submaximal_exercise_capacity_training_response_the_HERITAGE_Family_Study?f_ri=279027","dom_id":"work_75025188","summary":"Although regular exercise improves submaximal aerobic capacity, there is large variability in its response to exercise training. While this variation is thought to be partly due to genetic differences, relatively little is known about the causal genes. Submaximal aerobic capacity traits in the current report include the responses of oxygen consumption (ΔVO 2 60), power output (ΔWORK60), and cardiac output (ΔQ60) at 60% of VO 2 max to a standardized 20-week endurance exercise training program. Genome-wide linkage analysis in 475 HERITAGE Family Study Caucasians identified a locus on chromosome 13q for ΔVO 2 60 (LOD = 3.11). Follow-up fine mapping involved a dense marker panel of over 1,800 single-nucleotide polymorphisms (SNPs) in a 7.9-Mb region (21.1-29.1 Mb from p-terminus). Single-SNP analyses found 14 SNPs moderately associated with both ΔVO 2 60 at P ≤ 0.005 and the correlated traits of ΔWORK60 and ΔQ60 at P \u003c 0.05. Haplotype analyses provided several strong signals (P\u003c1.0 × 10 -5 ) for ΔVO 2 60. Overall, association analyses narrowed the target region and included potential biological candidate genes (MIPEP and SGCG). Consistent with maximal heritability estimates of 23%, up to 20% of the phenotypic variance in ΔVO 2 60 was accounted for by these SNPs. These results implicate candidate genes on chromosome 13q12 for the ability to improve submaximal exercise capacity in response to regular exercise. Submaximal exercise at 60% of maximal capacity is an exercise intensity that falls well within the range recommended in the Physical Activity Guidelines for Americans and thus has potential public health relevance.","downloadable_attachments":[{"id":82962464,"asset_id":75025188,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":219370942,"first_name":"Margarita","last_name":"Teran","domain_name":"independent","page_name":"MargaritaTeran6","display_name":"Margarita Teran","profile_url":"https://independent.academia.edu/MargaritaTeran6?f_ri=279027","photo":"https://0.academia-photos.com/219370942/112435653/101698865/s65_margarita.teran.png"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=279027","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":42324,"name":"Heredity","url":"https://www.academia.edu/Documents/in/Heredity?f_ri=279027","nofollow":true},{"id":86952,"name":"Haplotypes","url":"https://www.academia.edu/Documents/in/Haplotypes?f_ri=279027","nofollow":true},{"id":98134,"name":"United States","url":"https://www.academia.edu/Documents/in/United_States?f_ri=279027"},{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=279027"},{"id":188349,"name":"Pedigree","url":"https://www.academia.edu/Documents/in/Pedigree?f_ri=279027"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":403740,"name":"Single Nucleotide Polymorphism","url":"https://www.academia.edu/Documents/in/Single_Nucleotide_Polymorphism?f_ri=279027"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=279027"},{"id":547589,"name":"Quantitative Trait Loci","url":"https://www.academia.edu/Documents/in/Quantitative_Trait_Loci?f_ri=279027"},{"id":561981,"name":"European Continental Ancestry Group","url":"https://www.academia.edu/Documents/in/European_Continental_Ancestry_Group?f_ri=279027"},{"id":1146831,"name":"Exercise Test","url":"https://www.academia.edu/Documents/in/Exercise_Test?f_ri=279027"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption?f_ri=279027"},{"id":1210716,"name":"Exercise Tolerance","url":"https://www.academia.edu/Documents/in/Exercise_Tolerance?f_ri=279027"},{"id":2937977,"name":"Cardiac output","url":"https://www.academia.edu/Documents/in/Cardiac_output?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73820357" data-work_id="73820357" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73820357/Treatment_of_childhood_T_cell_lymphoblastic_lymphoma_according_to_the_strategy_for_acute_lymphoblastic_leukaemia_without_radiotherapy_Long_term_results_of_the_EORTC_CLG_58881_trial">Treatment of childhood T-cell lymphoblastic lymphoma according to the strategy for acute lymphoblastic leukaemia, without radiotherapy: Long term results of the EORTC CLG 58881 trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73820357" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="dcd16de4cd480c8519ba635a4480b2fc" rel="nofollow" data-download="{"attachment_id":82194948,"asset_id":73820357,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82194948/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33277154" href="https://independent.academia.edu/MarleenRenard">Marleen Renard</a><script data-card-contents-for-user="33277154" type="text/json">{"id":33277154,"first_name":"Marleen","last_name":"Renard","domain_name":"independent","page_name":"MarleenRenard","display_name":"Marleen Renard","profile_url":"https://independent.academia.edu/MarleenRenard?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73820357 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73820357"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73820357, container: ".js-paper-rank-work_73820357", }); });</script></li><li class="js-percentile-work_73820357 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73820357; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73820357"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73820357 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73820357"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73820357; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73820357]").text(description); $(".js-view-count-work_73820357").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73820357").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73820357"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4531" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" rel="nofollow" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a><script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73820357]'), work: {"id":73820357,"title":"Treatment of childhood T-cell lymphoblastic lymphoma according to the strategy for acute lymphoblastic leukaemia, without radiotherapy: Long term results of the EORTC CLG 58881 trial","created_at":"2022-03-15T07:01:16.553-07:00","url":"https://www.academia.edu/73820357/Treatment_of_childhood_T_cell_lymphoblastic_lymphoma_according_to_the_strategy_for_acute_lymphoblastic_leukaemia_without_radiotherapy_Long_term_results_of_the_EORTC_CLG_58881_trial?f_ri=279027","dom_id":"work_73820357","summary":null,"downloadable_attachments":[{"id":82194948,"asset_id":73820357,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33277154,"first_name":"Marleen","last_name":"Renard","domain_name":"independent","page_name":"MarleenRenard","display_name":"Marleen Renard","profile_url":"https://independent.academia.edu/MarleenRenard?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=279027","nofollow":true},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=279027","nofollow":true},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true},{"id":125175,"name":"Acute Lymphoblastic Leukaemia","url":"https://www.academia.edu/Documents/in/Acute_Lymphoblastic_Leukaemia?f_ri=279027"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=279027"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System?f_ri=279027"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=279027"},{"id":546940,"name":"Standard Error","url":"https://www.academia.edu/Documents/in/Standard_Error?f_ri=279027"},{"id":1225372,"name":"Overall Survival","url":"https://www.academia.edu/Documents/in/Overall_Survival?f_ri=279027"},{"id":2180163,"name":"Prophylactic Cranial Irradiation","url":"https://www.academia.edu/Documents/in/Prophylactic_Cranial_Irradiation?f_ri=279027"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=279027"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70722816" data-work_id="70722816" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70722816/Short_term_exercise_training_improves_diaphragm_antioxidant_capacity_and_endurance">Short-term exercise training improves diaphragm antioxidant capacity and endurance</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">These experiments tested the hypothesis that short-term endurance exercise training would rapidly improve (within 5 days) the diaphragm oxidative/antioxidant capacity and protect the diaphragm against contraction-induced oxidative stress.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70722816" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">These experiments tested the hypothesis that short-term endurance exercise training would rapidly improve (within 5 days) the diaphragm oxidative/antioxidant capacity and protect the diaphragm against contraction-induced oxidative stress. To test this postulate, male Sprague-Dawley rats (6 weeks old) ran on a motorized treadmill for 5 consecutive days (40-60 min x day(-1)) at approximately 65% maximal oxygen uptake. Costal diaphragm strips were excised from both sedentary control (CON, n=14) and trained (TR, n=13) animals 24 h after the last exercise session, for measurement of in vitro contraction properties and selected biochemical parameters of oxidative/antioxidant capacity. Training did not alter diaphragm force-frequency characteristics over a full range of submaximal and maximal stimulation frequencies (P &gt; 0.05). In contrast, training improved diaphragm resistance to fatigue as contraction forces were better-maintained by the diaphragms of the TR animals during a submaxim...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70722816" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2df21bea175cd97febfcfdd2d6418d64" rel="nofollow" data-download="{"attachment_id":80352842,"asset_id":70722816,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/80352842/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="196898209" href="https://independent.academia.edu/HaydarDemirel4">Haydar Demirel</a><script data-card-contents-for-user="196898209" type="text/json">{"id":196898209,"first_name":"Haydar","last_name":"Demirel","domain_name":"independent","page_name":"HaydarDemirel4","display_name":"Haydar Demirel","profile_url":"https://independent.academia.edu/HaydarDemirel4?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70722816 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70722816"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70722816, container: ".js-paper-rank-work_70722816", }); });</script></li><li class="js-percentile-work_70722816 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70722816; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_70722816"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_70722816 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="70722816"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70722816; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70722816]").text(description); $(".js-view-count-work_70722816").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70722816").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70722816"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" rel="nofollow" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" rel="nofollow" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27240" rel="nofollow" href="https://www.academia.edu/Documents/in/Prevention">Prevention</a>, <script data-card-contents-for-ri="27240" type="text/json">{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="112338" rel="nofollow" href="https://www.academia.edu/Documents/in/Oxidoreductases">Oxidoreductases</a><script data-card-contents-for-ri="112338" type="text/json">{"id":112338,"name":"Oxidoreductases","url":"https://www.academia.edu/Documents/in/Oxidoreductases?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70722816]'), work: {"id":70722816,"title":"Short-term exercise training improves diaphragm antioxidant capacity and endurance","created_at":"2022-02-06T09:42:50.317-08:00","url":"https://www.academia.edu/70722816/Short_term_exercise_training_improves_diaphragm_antioxidant_capacity_and_endurance?f_ri=279027","dom_id":"work_70722816","summary":"These experiments tested the hypothesis that short-term endurance exercise training would rapidly improve (within 5 days) the diaphragm oxidative/antioxidant capacity and protect the diaphragm against contraction-induced oxidative stress. To test this postulate, male Sprague-Dawley rats (6 weeks old) ran on a motorized treadmill for 5 consecutive days (40-60 min x day(-1)) at approximately 65% maximal oxygen uptake. Costal diaphragm strips were excised from both sedentary control (CON, n=14) and trained (TR, n=13) animals 24 h after the last exercise session, for measurement of in vitro contraction properties and selected biochemical parameters of oxidative/antioxidant capacity. Training did not alter diaphragm force-frequency characteristics over a full range of submaximal and maximal stimulation frequencies (P \u0026gt; 0.05). In contrast, training improved diaphragm resistance to fatigue as contraction forces were better-maintained by the diaphragms of the TR animals during a submaxim...","downloadable_attachments":[{"id":80352842,"asset_id":70722816,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":196898209,"first_name":"Haydar","last_name":"Demirel","domain_name":"independent","page_name":"HaydarDemirel4","display_name":"Haydar Demirel","profile_url":"https://independent.academia.edu/HaydarDemirel4?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=279027","nofollow":true},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=279027","nofollow":true},{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention?f_ri=279027","nofollow":true},{"id":112338,"name":"Oxidoreductases","url":"https://www.academia.edu/Documents/in/Oxidoreductases?f_ri=279027","nofollow":true},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione?f_ri=279027"},{"id":139007,"name":"Catalase","url":"https://www.academia.edu/Documents/in/Catalase?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat?f_ri=279027"},{"id":490253,"name":"Muscle Fatigue","url":"https://www.academia.edu/Documents/in/Muscle_Fatigue?f_ri=279027"},{"id":556021,"name":"Muscle contraction","url":"https://www.academia.edu/Documents/in/Muscle_contraction?f_ri=279027"},{"id":1014845,"name":"Physical Training","url":"https://www.academia.edu/Documents/in/Physical_Training?f_ri=279027"},{"id":1210717,"name":"Maximal Oxygen Uptake","url":"https://www.academia.edu/Documents/in/Maximal_Oxygen_Uptake?f_ri=279027"},{"id":1322481,"name":"Antioxidant Capacity","url":"https://www.academia.edu/Documents/in/Antioxidant_Capacity?f_ri=279027"},{"id":1416887,"name":"Citrate Synthase","url":"https://www.academia.edu/Documents/in/Citrate_Synthase?f_ri=279027"},{"id":2183225,"name":"Physical Endurance","url":"https://www.academia.edu/Documents/in/Physical_Endurance?f_ri=279027"},{"id":2506745,"name":"Contractility","url":"https://www.academia.edu/Documents/in/Contractility?f_ri=279027"},{"id":3099364,"name":"Exercise training","url":"https://www.academia.edu/Documents/in/Exercise_training?f_ri=279027"},{"id":3819273,"name":"Lipid peroxides","url":"https://www.academia.edu/Documents/in/Lipid_peroxides?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_67667576" data-work_id="67667576" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/67667576/Cloning_and_expression_of_a_Xenopus_liver_cDNA_encoding_a_fructose_phosphate_insensitive_regulatory_protein_of_glucokinase">Cloning and expression of a Xenopus liver cDNA encoding a fructose-phosphate-insensitive regulatory protein of glucokinase</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Xenopus liver contains a protein inhibitor of glucokinase that, in contrast to the mammalian regulatory protein of glucokinase, is insensitive to fructose 6-phosphate and fructose 1-phosphate [Vandercammen A. & Van Schaftingen, E. (1993)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_67667576" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Xenopus liver contains a protein inhibitor of glucokinase that, in contrast to the mammalian regulatory protein of glucokinase, is insensitive to fructose 6-phosphate and fructose 1-phosphate [Vandercammen A. & Van Schaftingen, E. (1993) Biochem. J. 294, 551-556]. The purpose of this work was to compare the primary structure and other properties of this Xenopus protein with those of its rat liver counterpart. A Xenopus laevis liver cDNA library was screened using the cDNA encoding the rat liver regulatory protein as a probe. The cloned cDNA was 2534 bp long and encoded a 619-amino-acid protein with a molecular mass of 68695 Da and 57% identity with the rat liver regulatory protein. This identity was only about 30% in an internal region (amino acids 349-381) and in the 70 carboxy terminal-residues. The Xenopus cDNA was expressed in Escherichia coli and the recombinant regulatory protein was purified to near homogeneity and found to have the same size, reactivity to antibodies and eff...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/67667576" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0843e37191f45283dfee03498e947a26" rel="nofollow" data-download="{"attachment_id":78404206,"asset_id":67667576,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/78404206/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52116447" href="https://independent.academia.edu/EmileSchaftingen">Emile Schaftingen</a><script data-card-contents-for-user="52116447" type="text/json">{"id":52116447,"first_name":"Emile","last_name":"Schaftingen","domain_name":"independent","page_name":"EmileSchaftingen","display_name":"Emile Schaftingen","profile_url":"https://independent.academia.edu/EmileSchaftingen?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_67667576 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="67667576"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 67667576, container: ".js-paper-rank-work_67667576", }); });</script></li><li class="js-percentile-work_67667576 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 67667576; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_67667576"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_67667576 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="67667576"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 67667576; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=67667576]").text(description); $(".js-view-count-work_67667576").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_67667576").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="67667576"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4987" rel="nofollow" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="27784" rel="nofollow" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a>, <script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="37834" rel="nofollow" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a>, <script data-card-contents-for-ri="37834" type="text/json">{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71437" rel="nofollow" href="https://www.academia.edu/Documents/in/Liver">Liver</a><script data-card-contents-for-ri="71437" type="text/json">{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=67667576]'), work: {"id":67667576,"title":"Cloning and expression of a Xenopus liver cDNA encoding a fructose-phosphate-insensitive regulatory protein of glucokinase","created_at":"2022-01-09T02:03:50.882-08:00","url":"https://www.academia.edu/67667576/Cloning_and_expression_of_a_Xenopus_liver_cDNA_encoding_a_fructose_phosphate_insensitive_regulatory_protein_of_glucokinase?f_ri=279027","dom_id":"work_67667576","summary":"Xenopus liver contains a protein inhibitor of glucokinase that, in contrast to the mammalian regulatory protein of glucokinase, is insensitive to fructose 6-phosphate and fructose 1-phosphate [Vandercammen A. \u0026 Van Schaftingen, E. (1993) Biochem. J. 294, 551-556]. The purpose of this work was to compare the primary structure and other properties of this Xenopus protein with those of its rat liver counterpart. A Xenopus laevis liver cDNA library was screened using the cDNA encoding the rat liver regulatory protein as a probe. The cloned cDNA was 2534 bp long and encoded a 619-amino-acid protein with a molecular mass of 68695 Da and 57% identity with the rat liver regulatory protein. This identity was only about 30% in an internal region (amino acids 349-381) and in the 70 carboxy terminal-residues. The Xenopus cDNA was expressed in Escherichia coli and the recombinant regulatory protein was purified to near homogeneity and found to have the same size, reactivity to antibodies and eff...","downloadable_attachments":[{"id":78404206,"asset_id":67667576,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52116447,"first_name":"Emile","last_name":"Schaftingen","domain_name":"independent","page_name":"EmileSchaftingen","display_name":"Emile Schaftingen","profile_url":"https://independent.academia.edu/EmileSchaftingen?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=279027","nofollow":true},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=279027","nofollow":true},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=279027","nofollow":true},{"id":71437,"name":"Liver","url":"https://www.academia.edu/Documents/in/Liver?f_ri=279027","nofollow":true},{"id":71445,"name":"Glucokinase","url":"https://www.academia.edu/Documents/in/Glucokinase?f_ri=279027"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":295728,"name":"Molecular cloning","url":"https://www.academia.edu/Documents/in/Molecular_cloning?f_ri=279027"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=279027"},{"id":477264,"name":"Xenopus laevis","url":"https://www.academia.edu/Documents/in/Xenopus_laevis?f_ri=279027"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=279027"},{"id":809882,"name":"Base Sequence","url":"https://www.academia.edu/Documents/in/Base_Sequence?f_ri=279027"},{"id":990417,"name":"Recombinant Proteins","url":"https://www.academia.edu/Documents/in/Recombinant_Proteins?f_ri=279027"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=279027"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=279027"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63951284" data-work_id="63951284" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" rel="nofollow" href="https://www.academia.edu/63951284/Haematological_reference_values_in_Spanish_adolescents_the_AVENA_study">Haematological reference values in Spanish adolescents: the AVENA study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63951284" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8b0186c9381eb3d86d0c6b89a54dcca2" rel="nofollow" data-download="{"attachment_id":76204637,"asset_id":63951284,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76204637/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33611256" rel="nofollow" href="https://independent.academia.edu/ManuelCastillo43">Manuel Castillo</a><script data-card-contents-for-user="33611256" type="text/json">{"id":33611256,"first_name":"Manuel","last_name":"Castillo","domain_name":"independent","page_name":"ManuelCastillo43","display_name":"Manuel Castillo","profile_url":"https://independent.academia.edu/ManuelCastillo43?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63951284 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63951284"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63951284, container: ".js-paper-rank-work_63951284", }); });</script></li><li class="js-percentile-work_63951284 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63951284; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_63951284"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_63951284 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="63951284"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63951284; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63951284]").text(description); $(".js-view-count-work_63951284").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63951284").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63951284"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="22506" rel="nofollow" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="40516" rel="nofollow" href="https://www.academia.edu/Documents/in/Spain">Spain</a>, <script data-card-contents-for-ri="40516" type="text/json">{"id":40516,"name":"Spain","url":"https://www.academia.edu/Documents/in/Spain?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="50781" rel="nofollow" href="https://www.academia.edu/Documents/in/Haematology">Haematology</a>, <script data-card-contents-for-ri="50781" type="text/json">{"id":50781,"name":"Haematology","url":"https://www.academia.edu/Documents/in/Haematology?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="192551" rel="nofollow" href="https://www.academia.edu/Documents/in/Nutritional_Status">Nutritional Status</a><script data-card-contents-for-ri="192551" type="text/json">{"id":192551,"name":"Nutritional Status","url":"https://www.academia.edu/Documents/in/Nutritional_Status?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63951284]'), work: {"id":63951284,"title":"Haematological reference values in Spanish adolescents: the AVENA study","created_at":"2021-12-13T01:09:40.357-08:00","url":"https://www.academia.edu/63951284/Haematological_reference_values_in_Spanish_adolescents_the_AVENA_study?f_ri=279027","dom_id":"work_63951284","summary":null,"downloadable_attachments":[{"id":76204637,"asset_id":63951284,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33611256,"first_name":"Manuel","last_name":"Castillo","domain_name":"independent","page_name":"ManuelCastillo43","display_name":"Manuel Castillo","profile_url":"https://independent.academia.edu/ManuelCastillo43?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=279027","nofollow":true},{"id":40516,"name":"Spain","url":"https://www.academia.edu/Documents/in/Spain?f_ri=279027","nofollow":true},{"id":50781,"name":"Haematology","url":"https://www.academia.edu/Documents/in/Haematology?f_ri=279027","nofollow":true},{"id":192551,"name":"Nutritional Status","url":"https://www.academia.edu/Documents/in/Nutritional_Status?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":570668,"name":"Urban Population","url":"https://www.academia.edu/Documents/in/Urban_Population?f_ri=279027"},{"id":1000427,"name":"Reference Values","url":"https://www.academia.edu/Documents/in/Reference_Values?f_ri=279027"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=279027"},{"id":1281375,"name":"Hematocrit","url":"https://www.academia.edu/Documents/in/Hematocrit?f_ri=279027"},{"id":1292656,"name":"Reference Value","url":"https://www.academia.edu/Documents/in/Reference_Value?f_ri=279027"},{"id":1311261,"name":"Hemoglobins","url":"https://www.academia.edu/Documents/in/Hemoglobins?f_ri=279027"},{"id":2677637,"name":"Sex Characteristics","url":"https://www.academia.edu/Documents/in/Sex_Characteristics?f_ri=279027"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61986011" data-work_id="61986011" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61986011/Shear_Bond_Strength_of_Orthodontic_Brackets_Cured_with_Different_Light_Sources_under_Thermocycling">Shear Bond Strength of Orthodontic Brackets Cured with Different Light Sources under Thermocycling</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of this study was to compare the shear bond strength (SBS) of two different light sources under different thermal cycle frequencies. Ninety human premolar teeth were divided into six groups, in which three groups consisted of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61986011" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of this study was to compare the shear bond strength (SBS) of two different light sources under different thermal cycle frequencies. Ninety human premolar teeth were divided into six groups, in which three groups consisted of halogen groups - Group I was cured with halogen without thermocycle, Group II cured with halogen with 500 thermocycles, and Group III cured with halogen with 10,000 thermocycles. The other three groups consisted of Plasma arc (PAC) group - Group IV was cured with PAC without thermocycle, Group V cured with PAC thermocycled 500 cycles, and Group VI cured with PAC thermocycled 10,000 cycles. Two way ANOVA was used to compare the SBS between the groups, and chi square-test was used to compare the bond failure of ARI scores among the groups. A significant difference was found for curing lights (P&lt;.001) and thermocycling (P&lt;.01). However, there was no interaction between light curing and thermocycling (P=.177). The halogen groups demonstrated higher me...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61986011" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0a1eca1acfa40bee15b2f443b5e8dea6" rel="nofollow" data-download="{"attachment_id":74874812,"asset_id":61986011,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74874812/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42629176" href="https://independent.academia.edu/OralSokucu">Oral Sokucu</a><script data-card-contents-for-user="42629176" type="text/json">{"id":42629176,"first_name":"Oral","last_name":"Sokucu","domain_name":"independent","page_name":"OralSokucu","display_name":"Oral Sokucu","profile_url":"https://independent.academia.edu/OralSokucu?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61986011 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61986011"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61986011, container: ".js-paper-rank-work_61986011", }); });</script></li><li class="js-percentile-work_61986011 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 61986011; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_61986011"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_61986011 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="61986011"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 61986011; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=61986011]").text(description); $(".js-view-count-work_61986011").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_61986011").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="61986011"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a><script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=61986011]'), work: {"id":61986011,"title":"Shear Bond Strength of Orthodontic Brackets Cured with Different Light Sources under Thermocycling","created_at":"2021-11-19T00:01:55.385-08:00","url":"https://www.academia.edu/61986011/Shear_Bond_Strength_of_Orthodontic_Brackets_Cured_with_Different_Light_Sources_under_Thermocycling?f_ri=279027","dom_id":"work_61986011","summary":"The aim of this study was to compare the shear bond strength (SBS) of two different light sources under different thermal cycle frequencies. Ninety human premolar teeth were divided into six groups, in which three groups consisted of halogen groups - Group I was cured with halogen without thermocycle, Group II cured with halogen with 500 thermocycles, and Group III cured with halogen with 10,000 thermocycles. The other three groups consisted of Plasma arc (PAC) group - Group IV was cured with PAC without thermocycle, Group V cured with PAC thermocycled 500 cycles, and Group VI cured with PAC thermocycled 10,000 cycles. Two way ANOVA was used to compare the SBS between the groups, and chi square-test was used to compare the bond failure of ARI scores among the groups. A significant difference was found for curing lights (P\u0026lt;.001) and thermocycling (P\u0026lt;.01). However, there was no interaction between light curing and thermocycling (P=.177). The halogen groups demonstrated higher me...","downloadable_attachments":[{"id":74874812,"asset_id":61986011,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42629176,"first_name":"Oral","last_name":"Sokucu","domain_name":"independent","page_name":"OralSokucu","display_name":"Oral Sokucu","profile_url":"https://independent.academia.edu/OralSokucu?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58420716" data-work_id="58420716" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58420716/Plasmacytoid_dendritic_cells_and_dermatological_disorders_focus_on_their_role_in_autoimmunity_and_cancer">Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dendritic cells (DC), considered as immunological sentinels of the organism since they are antigen presenting cells, create the link between innate and adaptive immunity. DC include myeloid dendritic cells (MDC) and plasmacytoid dendritic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_58420716" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dendritic cells (DC), considered as immunological sentinels of the organism since they are antigen presenting cells, create the link between innate and adaptive immunity. DC include myeloid dendritic cells (MDC) and plasmacytoid dendritic cells (PDC). The presence of PDC, cells capable of producing large quantities of interferon alpha (IFN-alpha) in response to pathogenic agents or danger signals, seems to be closely related to pathological conditions. PDC have been observed in inflammatory immunoallergic dermatological disorders, in malignant cutaneous tumours and in cutaneous lesions of infectious origin. They seem to play a crucial role in the initiation of the pathological processes of autoimmune diseases such as lupus or psoriasis. Their function within a tumour context is not as well known and is controversial. They could have a tolerogenic role towards tumour cells in the absence of an activator but they also have the capacity to become activated in response to Toll-like rece...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58420716" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2af14f21bff20f9bc499cb1e1d969438" rel="nofollow" data-download="{"attachment_id":72840008,"asset_id":58420716,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72840008/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="104300904" href="https://independent.academia.edu/MarieChristineJacob">Marie-Christine Jacob</a><script data-card-contents-for-user="104300904" type="text/json">{"id":104300904,"first_name":"Marie-Christine","last_name":"Jacob","domain_name":"independent","page_name":"MarieChristineJacob","display_name":"Marie-Christine Jacob","profile_url":"https://independent.academia.edu/MarieChristineJacob?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_58420716 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58420716"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58420716, container: ".js-paper-rank-work_58420716", }); });</script></li><li class="js-percentile-work_58420716 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 58420716; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_58420716"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_58420716 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="58420716"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 58420716; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=58420716]").text(description); $(".js-view-count-work_58420716").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_58420716").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="58420716"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="35539" rel="nofollow" href="https://www.academia.edu/Documents/in/Dendritic_Cells">Dendritic Cells</a>, <script data-card-contents-for-ri="35539" type="text/json">{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71304" rel="nofollow" href="https://www.academia.edu/Documents/in/Autoimmune_diseases">Autoimmune diseases</a>, <script data-card-contents-for-ri="71304" type="text/json">{"id":71304,"name":"Autoimmune diseases","url":"https://www.academia.edu/Documents/in/Autoimmune_diseases?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="229285" rel="nofollow" href="https://www.academia.edu/Documents/in/Skin_Diseases">Skin Diseases</a>, <script data-card-contents-for-ri="229285" type="text/json">{"id":229285,"name":"Skin Diseases","url":"https://www.academia.edu/Documents/in/Skin_Diseases?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=58420716]'), work: {"id":58420716,"title":"Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer","created_at":"2021-10-16T08:28:04.657-07:00","url":"https://www.academia.edu/58420716/Plasmacytoid_dendritic_cells_and_dermatological_disorders_focus_on_their_role_in_autoimmunity_and_cancer?f_ri=279027","dom_id":"work_58420716","summary":"Dendritic cells (DC), considered as immunological sentinels of the organism since they are antigen presenting cells, create the link between innate and adaptive immunity. DC include myeloid dendritic cells (MDC) and plasmacytoid dendritic cells (PDC). The presence of PDC, cells capable of producing large quantities of interferon alpha (IFN-alpha) in response to pathogenic agents or danger signals, seems to be closely related to pathological conditions. PDC have been observed in inflammatory immunoallergic dermatological disorders, in malignant cutaneous tumours and in cutaneous lesions of infectious origin. They seem to play a crucial role in the initiation of the pathological processes of autoimmune diseases such as lupus or psoriasis. Their function within a tumour context is not as well known and is controversial. They could have a tolerogenic role towards tumour cells in the absence of an activator but they also have the capacity to become activated in response to Toll-like rece...","downloadable_attachments":[{"id":72840008,"asset_id":58420716,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":104300904,"first_name":"Marie-Christine","last_name":"Jacob","domain_name":"independent","page_name":"MarieChristineJacob","display_name":"Marie-Christine Jacob","profile_url":"https://independent.academia.edu/MarieChristineJacob?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":35539,"name":"Dendritic Cells","url":"https://www.academia.edu/Documents/in/Dendritic_Cells?f_ri=279027","nofollow":true},{"id":71304,"name":"Autoimmune diseases","url":"https://www.academia.edu/Documents/in/Autoimmune_diseases?f_ri=279027","nofollow":true},{"id":229285,"name":"Skin Diseases","url":"https://www.academia.edu/Documents/in/Skin_Diseases?f_ri=279027","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":2028055,"name":"Interferon Alpha","url":"https://www.academia.edu/Documents/in/Interferon_Alpha?f_ri=279027"},{"id":2177223,"name":"Skin Neoplasms","url":"https://www.academia.edu/Documents/in/Skin_Neoplasms?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_52342100" data-work_id="52342100" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/52342100/Reliability_and_validity_of_the_EORTC_QLQ_C30_in_palliative_care_cancer_patients">Reliability and validity of the EORTC QLQ-C30 in palliative care cancer patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Palliative care aims at improving the patient’s quality of life. The assessment of this quality of life (QoL) is crucial for the evaluation of palliative care outcome. Many patients require hospital admissions for symptom control during... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_52342100" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Palliative care aims at improving the patient’s quality of life. The assessment of this quality of life (QoL) is crucial for the evaluation of palliative care outcome. Many patients require hospital admissions for symptom control during their cancer journey and most of them die in hospitals, although they would like to stay at home until the end of their lives. In 1986, the European Organization for Research and Treatment (EORTC) initiated a research programme to develop an integrated, modular approach for evaluating the quality of life of patients participating in international clinical trials. This questionnaire measures cancer patients’ physical, psychological and social functions and was used in a wide range of clinical cancer trials with large numbers of research groups and also in various other non-trial studies. The aim of this study was to evaluate the psychometric properties, especially the reliability, validity and applicability of the EORTC QLQ-C30 in a German sample of t...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/52342100" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="285f1c910be8bb471f3705de9205057b" rel="nofollow" data-download="{"attachment_id":69651335,"asset_id":52342100,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69651335/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="114538158" href="https://fhv.academia.edu/HJocham">Hubert Jocham</a><script data-card-contents-for-user="114538158" type="text/json">{"id":114538158,"first_name":"Hubert","last_name":"Jocham","domain_name":"fhv","page_name":"HJocham","display_name":"Hubert Jocham","profile_url":"https://fhv.academia.edu/HJocham?f_ri=279027","photo":"https://0.academia-photos.com/114538158/35990716/30997805/s65_hubert.jocham.jpg"}</script></span></span></li><li class="js-paper-rank-work_52342100 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="52342100"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 52342100, container: ".js-paper-rank-work_52342100", }); });</script></li><li class="js-percentile-work_52342100 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52342100; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_52342100"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_52342100 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="52342100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52342100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52342100]").text(description); $(".js-view-count-work_52342100").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_52342100").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="52342100"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4482" rel="nofollow" href="https://www.academia.edu/Documents/in/Palliative_Care">Palliative Care</a>, <script data-card-contents-for-ri="4482" type="text/json">{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="4531" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Trial">Clinical Trial</a>, <script data-card-contents-for-ri="4531" type="text/json">{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" rel="nofollow" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" rel="nofollow" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a><script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=52342100]'), work: {"id":52342100,"title":"Reliability and validity of the EORTC QLQ-C30 in palliative care cancer patients","created_at":"2021-09-14T12:12:23.253-07:00","url":"https://www.academia.edu/52342100/Reliability_and_validity_of_the_EORTC_QLQ_C30_in_palliative_care_cancer_patients?f_ri=279027","dom_id":"work_52342100","summary":"Palliative care aims at improving the patient’s quality of life. The assessment of this quality of life (QoL) is crucial for the evaluation of palliative care outcome. Many patients require hospital admissions for symptom control during their cancer journey and most of them die in hospitals, although they would like to stay at home until the end of their lives. In 1986, the European Organization for Research and Treatment (EORTC) initiated a research programme to develop an integrated, modular approach for evaluating the quality of life of patients participating in international clinical trials. This questionnaire measures cancer patients’ physical, psychological and social functions and was used in a wide range of clinical cancer trials with large numbers of research groups and also in various other non-trial studies. The aim of this study was to evaluate the psychometric properties, especially the reliability, validity and applicability of the EORTC QLQ-C30 in a German sample of t...","downloadable_attachments":[{"id":69651335,"asset_id":52342100,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":114538158,"first_name":"Hubert","last_name":"Jocham","domain_name":"fhv","page_name":"HJocham","display_name":"Hubert Jocham","profile_url":"https://fhv.academia.edu/HJocham?f_ri=279027","photo":"https://0.academia-photos.com/114538158/35990716/30997805/s65_hubert.jocham.jpg"}],"research_interests":[{"id":4482,"name":"Palliative Care","url":"https://www.academia.edu/Documents/in/Palliative_Care?f_ri=279027","nofollow":true},{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=279027","nofollow":true},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=279027","nofollow":true},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=279027","nofollow":true},{"id":82844,"name":"Health related Quality of Life","url":"https://www.academia.edu/Documents/in/Health_related_Quality_of_Life?f_ri=279027"},{"id":203835,"name":"Psychometric Properties","url":"https://www.academia.edu/Documents/in/Psychometric_Properties?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":329135,"name":"Social Functioning","url":"https://www.academia.edu/Documents/in/Social_Functioning?f_ri=279027"},{"id":532278,"name":"Cancer Patient","url":"https://www.academia.edu/Documents/in/Cancer_Patient?f_ri=279027"},{"id":589991,"name":"Patient Participation","url":"https://www.academia.edu/Documents/in/Patient_Participation?f_ri=279027"},{"id":3080489,"name":"Hospital Admission","url":"https://www.academia.edu/Documents/in/Hospital_Admission?f_ri=279027"},{"id":3093964,"name":"Reliability and validity","url":"https://www.academia.edu/Documents/in/Reliability_and_validity?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_51417134" data-work_id="51417134" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/51417134/Characterization_of_freezing_of_gait_subtypes_and_the_response_of_each_to_levodopa_in_Parkinsons_disease">Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To assess the effect of levodopa on distinct freezing of gait (FOG) subtypes in patients with ÔoffÕ FOG. Nineteen patients (12 men, mean age 62.0 ± 8.4 years) with Parkinson's disease and clinically significant FOG during ÔoffÕ states... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51417134" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To assess the effect of levodopa on distinct freezing of gait (FOG) subtypes in patients with ÔoffÕ FOG. Nineteen patients (12 men, mean age 62.0 ± 8.4 years) with Parkinson's disease and clinically significant FOG during ÔoffÕ states were videotaped whilst walking 130 m during ÔoffÕ and ÔonÕ states. Three independent observers characterized the type, duration, and clinical manifestations and quantified FOG by analyzing the videotapes. Their combined mean scores were used for statistical analysis. The intra-class correlation coefficient assessed inter-observer reliability. Wilcoxon and Friedman tests evaluated differences in mean frequencies of FOG characteristics. During ÔoffÕ states, FOG was elicited by turns (63%), starts (23%), walking through narrow spaces (12%) and reaching destinations (9%). These respective values were only 14, 4, 2 and 1% during ÔonÕ states (P < 0.011). Moving forward with very small steps and leg trembling in place were the most common manifestations of FOG; total akinesia was rare. Most FOG episodes took <10 s and tended to be shorter during ÔonÕ states. Levodopa significantly decreased FOG frequency (P < 0.0001) and the number of episodes with akinesia (P < 0.001). Distinction amongst FOG subtypes enables evaluation of distinctive therapeutic response. Levodopa helps in reducing the frequency and duration of ÔoffÕ-related FOG.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51417134" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f1ab738df304684f99413d10ba0a3d36" rel="nofollow" data-download="{"attachment_id":69151552,"asset_id":51417134,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/69151552/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="81594519" href="https://independent.academia.edu/YacovBalash">Yacov Balash</a><script data-card-contents-for-user="81594519" type="text/json">{"id":81594519,"first_name":"Yacov","last_name":"Balash","domain_name":"independent","page_name":"YacovBalash","display_name":"Yacov Balash","profile_url":"https://independent.academia.edu/YacovBalash?f_ri=279027","photo":"https://0.academia-photos.com/81594519/92358751/81199867/s65_yacov.balash.png"}</script></span></span></li><li class="js-paper-rank-work_51417134 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51417134"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51417134, container: ".js-paper-rank-work_51417134", }); });</script></li><li class="js-percentile-work_51417134 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 51417134; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_51417134"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_51417134 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="51417134"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 51417134; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=51417134]").text(description); $(".js-view-count-work_51417134").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_51417134").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="51417134"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="123230" rel="nofollow" href="https://www.academia.edu/Documents/in/Regression_Analysis">Regression Analysis</a>, <script data-card-contents-for-ri="123230" type="text/json">{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="198527" rel="nofollow" href="https://www.academia.edu/Documents/in/Motion">Motion</a>, <script data-card-contents-for-ri="198527" type="text/json">{"id":198527,"name":"Motion","url":"https://www.academia.edu/Documents/in/Motion?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="208014" rel="nofollow" href="https://www.academia.edu/Documents/in/Levodopa">Levodopa</a>, <script data-card-contents-for-ri="208014" type="text/json">{"id":208014,"name":"Levodopa","url":"https://www.academia.edu/Documents/in/Levodopa?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a><script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=51417134]'), work: {"id":51417134,"title":"Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease","created_at":"2021-09-07T05:10:05.762-07:00","url":"https://www.academia.edu/51417134/Characterization_of_freezing_of_gait_subtypes_and_the_response_of_each_to_levodopa_in_Parkinsons_disease?f_ri=279027","dom_id":"work_51417134","summary":"To assess the effect of levodopa on distinct freezing of gait (FOG) subtypes in patients with ÔoffÕ FOG. Nineteen patients (12 men, mean age 62.0 ± 8.4 years) with Parkinson's disease and clinically significant FOG during ÔoffÕ states were videotaped whilst walking 130 m during ÔoffÕ and ÔonÕ states. Three independent observers characterized the type, duration, and clinical manifestations and quantified FOG by analyzing the videotapes. Their combined mean scores were used for statistical analysis. The intra-class correlation coefficient assessed inter-observer reliability. Wilcoxon and Friedman tests evaluated differences in mean frequencies of FOG characteristics. During ÔoffÕ states, FOG was elicited by turns (63%), starts (23%), walking through narrow spaces (12%) and reaching destinations (9%). These respective values were only 14, 4, 2 and 1% during ÔonÕ states (P \u003c 0.011). Moving forward with very small steps and leg trembling in place were the most common manifestations of FOG; total akinesia was rare. Most FOG episodes took \u003c10 s and tended to be shorter during ÔonÕ states. Levodopa significantly decreased FOG frequency (P \u003c 0.0001) and the number of episodes with akinesia (P \u003c 0.001). Distinction amongst FOG subtypes enables evaluation of distinctive therapeutic response. Levodopa helps in reducing the frequency and duration of ÔoffÕ-related FOG.","downloadable_attachments":[{"id":69151552,"asset_id":51417134,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":81594519,"first_name":"Yacov","last_name":"Balash","domain_name":"independent","page_name":"YacovBalash","display_name":"Yacov Balash","profile_url":"https://independent.academia.edu/YacovBalash?f_ri=279027","photo":"https://0.academia-photos.com/81594519/92358751/81199867/s65_yacov.balash.png"}],"research_interests":[{"id":123230,"name":"Regression Analysis","url":"https://www.academia.edu/Documents/in/Regression_Analysis?f_ri=279027","nofollow":true},{"id":198527,"name":"Motion","url":"https://www.academia.edu/Documents/in/Motion?f_ri=279027","nofollow":true},{"id":208014,"name":"Levodopa","url":"https://www.academia.edu/Documents/in/Levodopa?f_ri=279027","nofollow":true},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=279027"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=279027"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=279027"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=279027"},{"id":462777,"name":"Leg","url":"https://www.academia.edu/Documents/in/Leg?f_ri=279027"},{"id":468209,"name":"Videotape Recording","url":"https://www.academia.edu/Documents/in/Videotape_Recording?f_ri=279027"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=279027"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=279027"},{"id":2444775,"name":"Psychomotor Performance","url":"https://www.academia.edu/Documents/in/Psychomotor_Performance?f_ri=279027"},{"id":2676416,"name":"parkinsonian disorders","url":"https://www.academia.edu/Documents/in/parkinsonian_disorders?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_48105183" data-work_id="48105183" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/48105183/The_protein_load_of_therapeutic_botulinum_toxins">The protein load of therapeutic botulinum toxins</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/48105183" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="338178964bd501f325bb5c27a7d2636b" rel="nofollow" data-download="{"attachment_id":66890749,"asset_id":48105183,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66890749/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="165473124" href="https://independent.academia.edu/PickettAndy">Andy Pickett</a><script data-card-contents-for-user="165473124" type="text/json">{"id":165473124,"first_name":"Andy","last_name":"Pickett","domain_name":"independent","page_name":"PickettAndy","display_name":"Andy Pickett","profile_url":"https://independent.academia.edu/PickettAndy?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_48105183 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="48105183"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 48105183, container: ".js-paper-rank-work_48105183", }); });</script></li><li class="js-percentile-work_48105183 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 48105183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_48105183"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_48105183 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="48105183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 48105183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=48105183]").text(description); $(".js-view-count-work_48105183").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_48105183").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="48105183"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="244814" rel="nofollow" href="https://www.academia.edu/Documents/in/Clinical_Sciences">Clinical Sciences</a>, <script data-card-contents-for-ri="244814" type="text/json">{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="802213" rel="nofollow" href="https://www.academia.edu/Documents/in/Lethal_Dose">Lethal Dose</a>, <script data-card-contents-for-ri="802213" type="text/json">{"id":802213,"name":"Lethal Dose","url":"https://www.academia.edu/Documents/in/Lethal_Dose?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="978869" rel="nofollow" href="https://www.academia.edu/Documents/in/Botulinum_Toxin">Botulinum Toxin</a><script data-card-contents-for-ri="978869" type="text/json">{"id":978869,"name":"Botulinum Toxin","url":"https://www.academia.edu/Documents/in/Botulinum_Toxin?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=48105183]'), work: {"id":48105183,"title":"The protein load of therapeutic botulinum toxins","created_at":"2021-05-04T01:06:21.006-07:00","url":"https://www.academia.edu/48105183/The_protein_load_of_therapeutic_botulinum_toxins?f_ri=279027","dom_id":"work_48105183","summary":null,"downloadable_attachments":[{"id":66890749,"asset_id":48105183,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":165473124,"first_name":"Andy","last_name":"Pickett","domain_name":"independent","page_name":"PickettAndy","display_name":"Andy Pickett","profile_url":"https://independent.academia.edu/PickettAndy?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":802213,"name":"Lethal Dose","url":"https://www.academia.edu/Documents/in/Lethal_Dose?f_ri=279027","nofollow":true},{"id":978869,"name":"Botulinum Toxin","url":"https://www.academia.edu/Documents/in/Botulinum_Toxin?f_ri=279027","nofollow":true},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47699014" data-work_id="47699014" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47699014/Ether_lipids_in_the_cell_membrane_of_Mycoplasma_fermentans">Ether lipids in the cell membrane of Mycoplasma fermentans</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Two new ether lipids, 1-O-alkyl/alkenyl-2-O-acyl-glycero-3-phosphocholine and its lyso form, 1-O-alkyl/ alkenyl-glycero-3-phosphocholine, were identified in the cell membrane of Mycoplasma fermentans using chemical analyses, GLC-MS,... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_47699014" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Two new ether lipids, 1-O-alkyl/alkenyl-2-O-acyl-glycero-3-phosphocholine and its lyso form, 1-O-alkyl/ alkenyl-glycero-3-phosphocholine, were identified in the cell membrane of Mycoplasma fermentans using chemical analyses, GLC-MS, MALDI-TOF MS, and 1D and 2D NMR spectroscopy. The lipids are heterogeneous with respect to both acyl and alkyl/alkenyl residues. The acyl residues at position 2 of glycerol are hexadecanoyl and octadecanoyl in a molar ratio of 3.6 : 1 with a trace amount of octadecenoyl. The alkyl/ alkenyl residues at position 1 of glycerol are hexadecyl (78%), octadecyl (7%), octadecenyl (14%), and hexadecenyl (traces). In the octadecenyl residue, the double bond has a cis configuration and is located at either position 1 H (plasmalogen-type lipid) or 9 H in a ratio < 1 : 1. This is the first report of the presence of alkyl and vinyl (alk-1 H -enyl) ether lipids in the cell membrane of aerobically grown mycoplasmas. Lipids of this type have been found in some Gram-positive bacteria, thus supporting the hypothesized close taxonomical relationship of these bacteria to mycoplasmas. The ether lipids of M. fermentans are structurally similar to platelet activating factor; it was demonstrated that the 2-O-acetylated lyso form lipid can mimic platelet-activating factor activity in isolated perfused and ventilated rat lungs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47699014" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d1c2ec4452cbe5ae645616a424eacda9" rel="nofollow" data-download="{"attachment_id":66657149,"asset_id":47699014,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/66657149/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="55934383" href="https://huji.academia.edu/ShlomoRottem">Shlomo Rottem</a><script data-card-contents-for-user="55934383" type="text/json">{"id":55934383,"first_name":"Shlomo","last_name":"Rottem","domain_name":"huji","page_name":"ShlomoRottem","display_name":"Shlomo Rottem","profile_url":"https://huji.academia.edu/ShlomoRottem?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_47699014 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47699014"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47699014, container: ".js-paper-rank-work_47699014", }); });</script></li><li class="js-percentile-work_47699014 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 47699014; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_47699014"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_47699014 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="47699014"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 47699014; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=47699014]").text(description); $(".js-view-count-work_47699014").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_47699014").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="47699014"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">15</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12134" rel="nofollow" href="https://www.academia.edu/Documents/in/NMR_Spectroscopy">NMR Spectroscopy</a>, <script data-card-contents-for-ri="12134" type="text/json">{"id":12134,"name":"NMR Spectroscopy","url":"https://www.academia.edu/Documents/in/NMR_Spectroscopy?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="21732" rel="nofollow" href="https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy">Magnetic Resonance Spectroscopy</a>, <script data-card-contents-for-ri="21732" type="text/json">{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="154672" rel="nofollow" href="https://www.academia.edu/Documents/in/Membrane_Lipids">Membrane Lipids</a>, <script data-card-contents-for-ri="154672" type="text/json">{"id":154672,"name":"Membrane Lipids","url":"https://www.academia.edu/Documents/in/Membrane_Lipids?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="166448" rel="nofollow" href="https://www.academia.edu/Documents/in/Gas_Chromatography">Gas Chromatography</a><script data-card-contents-for-ri="166448" type="text/json">{"id":166448,"name":"Gas Chromatography","url":"https://www.academia.edu/Documents/in/Gas_Chromatography?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=47699014]'), work: {"id":47699014,"title":"Ether lipids in the cell membrane of Mycoplasma fermentans","created_at":"2021-04-24T01:21:17.506-07:00","url":"https://www.academia.edu/47699014/Ether_lipids_in_the_cell_membrane_of_Mycoplasma_fermentans?f_ri=279027","dom_id":"work_47699014","summary":"Two new ether lipids, 1-O-alkyl/alkenyl-2-O-acyl-glycero-3-phosphocholine and its lyso form, 1-O-alkyl/ alkenyl-glycero-3-phosphocholine, were identified in the cell membrane of Mycoplasma fermentans using chemical analyses, GLC-MS, MALDI-TOF MS, and 1D and 2D NMR spectroscopy. The lipids are heterogeneous with respect to both acyl and alkyl/alkenyl residues. The acyl residues at position 2 of glycerol are hexadecanoyl and octadecanoyl in a molar ratio of 3.6 : 1 with a trace amount of octadecenoyl. The alkyl/ alkenyl residues at position 1 of glycerol are hexadecyl (78%), octadecyl (7%), octadecenyl (14%), and hexadecenyl (traces). In the octadecenyl residue, the double bond has a cis configuration and is located at either position 1 H (plasmalogen-type lipid) or 9 H in a ratio \u003c 1 : 1. This is the first report of the presence of alkyl and vinyl (alk-1 H -enyl) ether lipids in the cell membrane of aerobically grown mycoplasmas. Lipids of this type have been found in some Gram-positive bacteria, thus supporting the hypothesized close taxonomical relationship of these bacteria to mycoplasmas. The ether lipids of M. fermentans are structurally similar to platelet activating factor; it was demonstrated that the 2-O-acetylated lyso form lipid can mimic platelet-activating factor activity in isolated perfused and ventilated rat lungs.","downloadable_attachments":[{"id":66657149,"asset_id":47699014,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":55934383,"first_name":"Shlomo","last_name":"Rottem","domain_name":"huji","page_name":"ShlomoRottem","display_name":"Shlomo Rottem","profile_url":"https://huji.academia.edu/ShlomoRottem?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12134,"name":"NMR Spectroscopy","url":"https://www.academia.edu/Documents/in/NMR_Spectroscopy?f_ri=279027","nofollow":true},{"id":21732,"name":"Magnetic Resonance Spectroscopy","url":"https://www.academia.edu/Documents/in/Magnetic_Resonance_Spectroscopy?f_ri=279027","nofollow":true},{"id":154672,"name":"Membrane Lipids","url":"https://www.academia.edu/Documents/in/Membrane_Lipids?f_ri=279027","nofollow":true},{"id":166448,"name":"Gas Chromatography","url":"https://www.academia.edu/Documents/in/Gas_Chromatography?f_ri=279027","nofollow":true},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=279027"},{"id":204388,"name":"Vasoconstriction","url":"https://www.academia.edu/Documents/in/Vasoconstriction?f_ri=279027"},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=279027"},{"id":529560,"name":"Gas Chromatography/mass Spectrometry","url":"https://www.academia.edu/Documents/in/Gas_Chromatography_mass_Spectrometry?f_ri=279027"},{"id":888739,"name":"Quntitative Thin Layer Chromatography","url":"https://www.academia.edu/Documents/in/Quntitative_Thin_Layer_Chromatography?f_ri=279027"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=279027"},{"id":2369445,"name":"Pulmonary Artery","url":"https://www.academia.edu/Documents/in/Pulmonary_Artery?f_ri=279027"},{"id":2468093,"name":"Cell Membrane","url":"https://www.academia.edu/Documents/in/Cell_Membrane?f_ri=279027"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics?f_ri=279027"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34369819" data-work_id="34369819" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34369819/Post_partum_urinary_retention_a_comparison_between_two_methods_of_epidural_analgesia">Post-partum urinary retention: a comparison between two methods of epidural analgesia</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To compare two methods of epidural labor analgesia regarding the incidence of post-partum urinary retention. Study design: One thousand parturients who requested epidural analgesia for the relief of labor pain received, at... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34369819" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To compare two methods of epidural labor analgesia regarding the incidence of post-partum urinary retention. Study design: One thousand parturients who requested epidural analgesia for the relief of labor pain received, at random, either bupivacaine 0.25% with adrenaline l:200 000 (n = 500) or bupivacaine 0.125% with 10 t/g sufentanil (n = 500). During the same observation period all women with clinically significant urinary retention ( > 500 ml, requiring indwelling catheter) were registered. Result: Altogether 30/3.364 parturients had clinically significant urinary retention. Twenty-seven of these had received epidural analgesia (EDA) (17 with bupivacaine/adrenaline and ten with bupivacaine/sufentanil, a non-significant differences). The number of parturients with urinary retention was highly increased following EDA (27/1000) as compared to those not receiving EDA (3/2364), P < 0.001 (Fisher's exact test). In patients with EDA and urinary retention there were no difference between the groups in the incidence of instrumental deliveries or vaginal/perirectal tears. All parturients regained normal bladder function. Conchtsion: EDA significantly increased the risk of post-partum urinary retention but no difference was found between the two epidural techniques.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34369819" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7ba9b0dea0b2ccb23dc6402edfd16a16" rel="nofollow" data-download="{"attachment_id":54258538,"asset_id":34369819,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54258538/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="67639990" href="https://ki.academia.edu/GunvorEkmanOrdeberg">Gunvor Ekman-Ordeberg</a><script data-card-contents-for-user="67639990" type="text/json">{"id":67639990,"first_name":"Gunvor","last_name":"Ekman-Ordeberg","domain_name":"ki","page_name":"GunvorEkmanOrdeberg","display_name":"Gunvor Ekman-Ordeberg","profile_url":"https://ki.academia.edu/GunvorEkmanOrdeberg?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34369819 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34369819"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34369819, container: ".js-paper-rank-work_34369819", }); });</script></li><li class="js-percentile-work_34369819 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 34369819; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_34369819"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_34369819 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="34369819"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 34369819; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=34369819]").text(description); $(".js-view-count-work_34369819").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34369819").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34369819"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">8</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="62550" rel="nofollow" href="https://www.academia.edu/Documents/in/Pregnancy">Pregnancy</a>, <script data-card-contents-for-ri="62550" type="text/json">{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="71454" rel="nofollow" href="https://www.academia.edu/Documents/in/Epinephrine">Epinephrine</a>, <script data-card-contents-for-ri="71454" type="text/json">{"id":71454,"name":"Epinephrine","url":"https://www.academia.edu/Documents/in/Epinephrine?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="538554" rel="nofollow" href="https://www.academia.edu/Documents/in/Study_design">Study design</a><script data-card-contents-for-ri="538554" type="text/json">{"id":538554,"name":"Study design","url":"https://www.academia.edu/Documents/in/Study_design?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34369819]'), work: {"id":34369819,"title":"Post-partum urinary retention: a comparison between two methods of epidural analgesia","created_at":"2017-08-27T09:20:19.941-07:00","url":"https://www.academia.edu/34369819/Post_partum_urinary_retention_a_comparison_between_two_methods_of_epidural_analgesia?f_ri=279027","dom_id":"work_34369819","summary":"Objective: To compare two methods of epidural labor analgesia regarding the incidence of post-partum urinary retention. Study design: One thousand parturients who requested epidural analgesia for the relief of labor pain received, at random, either bupivacaine 0.25% with adrenaline l:200 000 (n = 500) or bupivacaine 0.125% with 10 t/g sufentanil (n = 500). During the same observation period all women with clinically significant urinary retention ( \u003e 500 ml, requiring indwelling catheter) were registered. Result: Altogether 30/3.364 parturients had clinically significant urinary retention. Twenty-seven of these had received epidural analgesia (EDA) (17 with bupivacaine/adrenaline and ten with bupivacaine/sufentanil, a non-significant differences). The number of parturients with urinary retention was highly increased following EDA (27/1000) as compared to those not receiving EDA (3/2364), P \u003c 0.001 (Fisher's exact test). In patients with EDA and urinary retention there were no difference between the groups in the incidence of instrumental deliveries or vaginal/perirectal tears. All parturients regained normal bladder function. Conchtsion: EDA significantly increased the risk of post-partum urinary retention but no difference was found between the two epidural techniques.","downloadable_attachments":[{"id":54258538,"asset_id":34369819,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":67639990,"first_name":"Gunvor","last_name":"Ekman-Ordeberg","domain_name":"ki","page_name":"GunvorEkmanOrdeberg","display_name":"Gunvor Ekman-Ordeberg","profile_url":"https://ki.academia.edu/GunvorEkmanOrdeberg?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy?f_ri=279027","nofollow":true},{"id":71454,"name":"Epinephrine","url":"https://www.academia.edu/Documents/in/Epinephrine?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":538554,"name":"Study design","url":"https://www.academia.edu/Documents/in/Study_design?f_ri=279027","nofollow":true},{"id":723159,"name":"Thoracic epidural analgesia","url":"https://www.academia.edu/Documents/in/Thoracic_epidural_analgesia?f_ri=279027"},{"id":1128448,"name":"Urinary retention","url":"https://www.academia.edu/Documents/in/Urinary_retention?f_ri=279027"},{"id":1535953,"name":"Epidural Analgesia","url":"https://www.academia.edu/Documents/in/Epidural_Analgesia?f_ri=279027"},{"id":2560488,"name":"Bupivacaine","url":"https://www.academia.edu/Documents/in/Bupivacaine?f_ri=279027"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33259510" data-work_id="33259510" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/33259510/Disseminated_cat_scratch_disease_Detection_ofRochalimaea_henselae_in_affected_tissue">Disseminated cat-scratch disease: Detection ofRochalimaea henselae in affected tissue</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">year-old boy with disseminated catscratch disease involving spleen, cervical and abdominal lymph nodes, skull, and one clavicle is reported.</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/33259510" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b6699d721300019ccac2daf1b64dd859" rel="nofollow" data-download="{"attachment_id":53329532,"asset_id":33259510,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/53329532/download_file?st=MTc0MDE1MjUxOSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="64860023" href="https://independent.academia.edu/RussellRegnery">Russell Regnery</a><script data-card-contents-for-user="64860023" type="text/json">{"id":64860023,"first_name":"Russell","last_name":"Regnery","domain_name":"independent","page_name":"RussellRegnery","display_name":"Russell Regnery","profile_url":"https://independent.academia.edu/RussellRegnery?f_ri=279027","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_33259510 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="33259510"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 33259510, container: ".js-paper-rank-work_33259510", }); });</script></li><li class="js-percentile-work_33259510 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33259510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_33259510"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_33259510 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="33259510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33259510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33259510]").text(description); $(".js-view-count-work_33259510").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_33259510").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="33259510"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="64933" rel="nofollow" href="https://www.academia.edu/Documents/in/Child">Child</a>, <script data-card-contents-for-ri="64933" type="text/json">{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="118339" rel="nofollow" href="https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction">Polymerase Chain Reaction</a>, <script data-card-contents-for-ri="118339" type="text/json">{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="279027" rel="nofollow" href="https://www.academia.edu/Documents/in/European">European</a>, <script data-card-contents-for-ri="279027" type="text/json">{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="410370" rel="nofollow" href="https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1">Public health systems and services research</a><script data-card-contents-for-ri="410370" type="text/json">{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=279027","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=33259510]'), work: {"id":33259510,"title":"Disseminated cat-scratch disease: Detection ofRochalimaea henselae in affected tissue","created_at":"2017-05-30T05:49:51.047-07:00","url":"https://www.academia.edu/33259510/Disseminated_cat_scratch_disease_Detection_ofRochalimaea_henselae_in_affected_tissue?f_ri=279027","dom_id":"work_33259510","summary":"year-old boy with disseminated catscratch disease involving spleen, cervical and abdominal lymph nodes, skull, and one clavicle is reported.","downloadable_attachments":[{"id":53329532,"asset_id":33259510,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":64860023,"first_name":"Russell","last_name":"Regnery","domain_name":"independent","page_name":"RussellRegnery","display_name":"Russell Regnery","profile_url":"https://independent.academia.edu/RussellRegnery?f_ri=279027","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=279027","nofollow":true},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction?f_ri=279027","nofollow":true},{"id":279027,"name":"European","url":"https://www.academia.edu/Documents/in/European?f_ri=279027","nofollow":true},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=279027","nofollow":true}]}, }) } })();</script></ul></li></ul></div></div></div><div class="u-taCenter Pagination"><ul class="pagination"><li class="next_page"><a href="/Documents/in/European?after=50%2C33259510" rel="next">Next</a></li><li class="last next"><a href="/Documents/in/European?page=last">Last »</a></li></ul></div></div><div class="hidden-xs hidden-sm"><div class="u-pl6x"><div style="width: 300px;"><div class="panel panel-flat u-mt7x"><div class="panel-heading u-p5x"><div class="u-tcGrayDark u-taCenter u-fw700 u-textUppercase">Related Topics</div></div><ul class="list-group"><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Net_Present_Value">Net Present Value</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="313338">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="313338">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Golden_Ratio">Golden Ratio</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="536828">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="536828">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Nordic">Nordic</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="458667">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="458667">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Customer_Service">Customer Service</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="103658">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="103658">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Gotthard_Railway_Switzerland_transportation_landscape_national_identity">Gotthard Railway Switzerland transportation landscape national identity</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="98710">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="98710">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease">Inflammatory Bowel Disease</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="59366">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="59366">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Strategic_Alliances">Strategic Alliances</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="5723">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="5723">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Scandinavian_Mythology">Scandinavian Mythology</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="740628">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="740628">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology">Biochemistry and cell biology</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="1681026">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="1681026">Following</a></div></li><li class="list-group-item media_v2 u-mt0x u-p3x"><div class="media-body"><div class="u-tcGrayDarker u-fw700"><a class="u-tcGrayDarker" rel="nofollow" href="https://www.academia.edu/Documents/in/Glycoproteins">Glycoproteins</a></div></div><div class="media-right media-middle"><a class="u-tcGreen u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-follow-ri-id="191439">Follow</a><a class="u-tcGray u-textDecorationNone u-linkUnstyled u-fw500 hidden" data-unfollow-ri-id="191439">Following</a></div></li></ul></div></div></div></div></div></div><script>// MIT License // Copyright © 2011 Sebastian Tschan, https://blueimp.net // Permission is hereby granted, free of charge, to any person obtaining a copy of // this software and associated documentation files (the "Software"), to deal in // the Software without restriction, including without limitation the rights to // use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of // the Software, and to permit persons to whom the Software is furnished to do so, // subject to the following conditions: // The above copyright notice and this permission notice shall be included in all // copies or substantial portions of the Software. // THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR // IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS // FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR // COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER // IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN // CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. !function(n){"use strict";function d(n,t){var r=(65535&n)+(65535&t);return(n>>16)+(t>>16)+(r>>16)<<16|65535&r}function f(n,t,r,e,o,u){return d((c=d(d(t,n),d(e,u)))<<(f=o)|c>>>32-f,r);var c,f}function l(n,t,r,e,o,u,c){return f(t&r|~t&e,n,t,o,u,c)}function v(n,t,r,e,o,u,c){return f(t&e|r&~e,n,t,o,u,c)}function g(n,t,r,e,o,u,c){return f(t^r^e,n,t,o,u,c)}function m(n,t,r,e,o,u,c){return f(r^(t|~e),n,t,o,u,c)}function i(n,t){var r,e,o,u;n[t>>5]|=128<<t%32,n[14+(t+64>>>9<<4)]=t;for(var c=1732584193,f=-271733879,i=-1732584194,a=271733878,h=0;h<n.length;h+=16)c=l(r=c,e=f,o=i,u=a,n[h],7,-680876936),a=l(a,c,f,i,n[h+1],12,-389564586),i=l(i,a,c,f,n[h+2],17,606105819),f=l(f,i,a,c,n[h+3],22,-1044525330),c=l(c,f,i,a,n[h+4],7,-176418897),a=l(a,c,f,i,n[h+5],12,1200080426),i=l(i,a,c,f,n[h+6],17,-1473231341),f=l(f,i,a,c,n[h+7],22,-45705983),c=l(c,f,i,a,n[h+8],7,1770035416),a=l(a,c,f,i,n[h+9],12,-1958414417),i=l(i,a,c,f,n[h+10],17,-42063),f=l(f,i,a,c,n[h+11],22,-1990404162),c=l(c,f,i,a,n[h+12],7,1804603682),a=l(a,c,f,i,n[h+13],12,-40341101),i=l(i,a,c,f,n[h+14],17,-1502002290),c=v(c,f=l(f,i,a,c,n[h+15],22,1236535329),i,a,n[h+1],5,-165796510),a=v(a,c,f,i,n[h+6],9,-1069501632),i=v(i,a,c,f,n[h+11],14,643717713),f=v(f,i,a,c,n[h],20,-373897302),c=v(c,f,i,a,n[h+5],5,-701558691),a=v(a,c,f,i,n[h+10],9,38016083),i=v(i,a,c,f,n[h+15],14,-660478335),f=v(f,i,a,c,n[h+4],20,-405537848),c=v(c,f,i,a,n[h+9],5,568446438),a=v(a,c,f,i,n[h+14],9,-1019803690),i=v(i,a,c,f,n[h+3],14,-187363961),f=v(f,i,a,c,n[h+8],20,1163531501),c=v(c,f,i,a,n[h+13],5,-1444681467),a=v(a,c,f,i,n[h+2],9,-51403784),i=v(i,a,c,f,n[h+7],14,1735328473),c=g(c,f=v(f,i,a,c,n[h+12],20,-1926607734),i,a,n[h+5],4,-378558),a=g(a,c,f,i,n[h+8],11,-2022574463),i=g(i,a,c,f,n[h+11],16,1839030562),f=g(f,i,a,c,n[h+14],23,-35309556),c=g(c,f,i,a,n[h+1],4,-1530992060),a=g(a,c,f,i,n[h+4],11,1272893353),i=g(i,a,c,f,n[h+7],16,-155497632),f=g(f,i,a,c,n[h+10],23,-1094730640),c=g(c,f,i,a,n[h+13],4,681279174),a=g(a,c,f,i,n[h],11,-358537222),i=g(i,a,c,f,n[h+3],16,-722521979),f=g(f,i,a,c,n[h+6],23,76029189),c=g(c,f,i,a,n[h+9],4,-640364487),a=g(a,c,f,i,n[h+12],11,-421815835),i=g(i,a,c,f,n[h+15],16,530742520),c=m(c,f=g(f,i,a,c,n[h+2],23,-995338651),i,a,n[h],6,-198630844),a=m(a,c,f,i,n[h+7],10,1126891415),i=m(i,a,c,f,n[h+14],15,-1416354905),f=m(f,i,a,c,n[h+5],21,-57434055),c=m(c,f,i,a,n[h+12],6,1700485571),a=m(a,c,f,i,n[h+3],10,-1894986606),i=m(i,a,c,f,n[h+10],15,-1051523),f=m(f,i,a,c,n[h+1],21,-2054922799),c=m(c,f,i,a,n[h+8],6,1873313359),a=m(a,c,f,i,n[h+15],10,-30611744),i=m(i,a,c,f,n[h+6],15,-1560198380),f=m(f,i,a,c,n[h+13],21,1309151649),c=m(c,f,i,a,n[h+4],6,-145523070),a=m(a,c,f,i,n[h+11],10,-1120210379),i=m(i,a,c,f,n[h+2],15,718787259),f=m(f,i,a,c,n[h+9],21,-343485551),c=d(c,r),f=d(f,e),i=d(i,o),a=d(a,u);return[c,f,i,a]}function a(n){for(var t="",r=32*n.length,e=0;e<r;e+=8)t+=String.fromCharCode(n[e>>5]>>>e%32&255);return t}function h(n){var t=[];for(t[(n.length>>2)-1]=void 0,e=0;e<t.length;e+=1)t[e]=0;for(var r=8*n.length,e=0;e<r;e+=8)t[e>>5]|=(255&n.charCodeAt(e/8))<<e%32;return t}function e(n){for(var t,r="0123456789abcdef",e="",o=0;o<n.length;o+=1)t=n.charCodeAt(o),e+=r.charAt(t>>>4&15)+r.charAt(15&t);return e}function r(n){return unescape(encodeURIComponent(n))}function o(n){return a(i(h(t=r(n)),8*t.length));var t}function u(n,t){return function(n,t){var r,e,o=h(n),u=[],c=[];for(u[15]=c[15]=void 0,16<o.length&&(o=i(o,8*n.length)),r=0;r<16;r+=1)u[r]=909522486^o[r],c[r]=1549556828^o[r];return e=i(u.concat(h(t)),512+8*t.length),a(i(c.concat(e),640))}(r(n),r(t))}function t(n,t,r){return t?r?u(t,n):e(u(t,n)):r?o(n):e(o(n))}"function"==typeof define&&define.amd?define(function(){return t}):"object"==typeof module&&module.exports?module.exports=t:n.md5=t}(this);</script><script>window.AbTest = (function() { return { 'ab_test': (uniqueId, test_name, buckets) => { let override = new URLSearchParams(window.location.search).get(`ab_test[${test_name}]`); if ( override ) { return override; } const bucketNames = buckets.map((bucket) => { return typeof bucket === 'string' ? bucket : Object.keys(bucket)[0]; }); const weights = buckets.map((bucket) => { return typeof bucket === 'string' ? 1 : Object.values(bucket)[0]; }); const total = weights.reduce((sum, weight) => sum + weight); const hash = md5(`${uniqueId}${test_name}`); const hashNum = parseInt(hash.slice(-12), 16); let bucketPoint = total * (hashNum % 100000) / 100000; const bucket = bucketNames.find((_, i) => { if (weights[i] > bucketPoint) { return true; } bucketPoint -= weights[i]; return false; }); return bucket; } }; })();</script><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-landing_url="https://www.academia.edu/Documents/in/European" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><script>function onGoogleOneTapEvent(event) { var momentType = event.getMomentType(); var momentReason = null; if (event.isNotDisplayed()) { momentReason = event.getNotDisplayedReason(); } else if (event.isSkippedMoment()) { momentReason = event.getSkippedReason(); } else if (event.isDismissedMoment()) { momentReason = event.getDismissedReason(); } Aedu.arbitraryEvents.write('GoogleOneTapEvent', { moment_type: momentType, moment_reason: momentReason, }); }</script><script>(function() { var auvid = unescape( document.cookie .split(/; ?/) .find((s) => s.startsWith('auvid')) .substring(6)); var bucket = AbTest.ab_test(auvid, 'lo_ri_one_tap_google_sign_on', ['control', 'one_tap_google_sign_on']); if (bucket === 'control') return; var oneTapTag = document.createElement('script') oneTapTag.async = true oneTapTag.defer = true oneTapTag.src = 'https://accounts.google.com/gsi/client' document.body.appendChild(oneTapTag) })();</script></div></div></div> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "4797a580a82d47aaac4567e15f3ee09572eaf225fa6f8adf8ff577bd28efb4c9", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="kd9ntRQenxw4nN5eXBTJSAtclp9rdq8Op0r4Cy4k94gvyQzYF2CUjJWkXQMXLjG4xStT9ubxdwAbOWtlKLNr-Q" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/Documents/in/European" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="m8DAac-harUh8hMd01AbDAHK-eq1vamB0CodOdtUvH8l1qsEzN9hJYzKkECYauP8z708gzg6cY9sWY5X3cMgDg" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>