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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="fDeKdjSyeLfAInC/HPzthsx1wSSTL+Vo3AzdOrZLXUP1klzCJnkLNdJUrAjt1nGZOhn1/ZyfSSOphngsPMY6Pg==" /> <meta name="citation_title" content="Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis" /> <meta name="citation_publication_date" content="2015/01/20" /> <meta name="citation_journal_title" content="Microbiology (Reading, England)" /> <meta name="citation_author" content="JUAN LOPEZ" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/12232187/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis" /> <meta name="twitter:title" content="Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis" /> <meta name="twitter:description" content="Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. 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Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus" /> <title>(PDF) Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis | JUAN LOPEZ - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/11354573/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732413160000); window.Aedu.timeDifference = new Date().getTime() - 1732413160000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...","author":[{"@context":"https://schema.org","@type":"Person","name":"JUAN LOPEZ"}],"contributor":[],"dateCreated":"2015-05-04","dateModified":"2015-05-04","datePublished":"2015-01-20","headline":"Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis","inLanguage":"en","keywords":[],"locationCreated":null,"publication":"Microbiology (Reading, England)","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/12232187/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"unearte"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link 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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F12232187%2FHuman_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F12232187%2FHuman_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":46291434,"identifier":"Attachment_46291434","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":12232187,"created_at":"2015-05-04T13:47:04.339-07:00","from_world_paper_id":135965416,"updated_at":"2021-01-12T16:44:01.750-08:00","_data":{"abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...","publication_date":"2015,1,20","publication_name":"Microbiology (Reading, England)"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [30716972]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":46291434,"attachmentType":"pdf"}"><img alt="First page of “Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/46291434/mini_magick20190210-28557-134osnn.png?1549799130" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="30716972" href="https://unearte.academia.edu/JUANLOPEZ"><img alt="Profile image of JUAN LOPEZ" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />JUAN LOPEZ</a></div><p class="ds-work-card--detail ds2-5-body-sm">2015, Microbiology (Reading, England)</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":46291434,"attachmentType":"pdf","workUrl":"https://www.academia.edu/12232187/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":46291434,"attachmentType":"pdf","workUrl":"https://www.academia.edu/12232187/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="46291434" data-landing_url="https://www.academia.edu/12232187/Human_neutrophils_produce_extracellular_traps_against_Paracoccidioides_brasiliensis" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="27439831" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27439831/Short_report_Inhibition_by_tumor_necrosis_factor_alpha_activated_macrophages_of_the_transition_of_Paracoccidioides_brasiliensis_conidia_to_yeast_cells_through_a_mechanism_independent_of_nitric_oxide">Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34118682" href="https://independent.academia.edu/AngelaRestrepo2">Angela Restrepo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American journal of tropical medicine and hygiene, 2004</p><p class="ds-related-work--abstract ds2-5-body-sm">It is known that peritoneal murine macrophages activated with interferon-gamma exert a fungicidal effect against Paracoccidioides brasiliensis conidia by a nitric oxide (NO)-mediated mechanism. This NO-mediated effect can also be induced by other cytokines such as tumor necrosis factor-alpha (TNF-alpha). The aim of this study was to determine if TNF-alpha-activated peritoneal murine macrophages infected with P. brasiliensis were able to show fungistatic/fungicidal effects mediated by NO. The results indicated that although macrophage activation with TNF-alpha did not result in NO production, these cells played an important role in inhibiting the conidia from becoming yeast cells. In vivo, the NO-independent inhibitory effect would prove of importance for the establishment of P. brasiliensis in host tissues.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide","attachmentId":47696930,"attachmentType":"pdf","work_url":"https://www.academia.edu/27439831/Short_report_Inhibition_by_tumor_necrosis_factor_alpha_activated_macrophages_of_the_transition_of_Paracoccidioides_brasiliensis_conidia_to_yeast_cells_through_a_mechanism_independent_of_nitric_oxide","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27439831/Short_report_Inhibition_by_tumor_necrosis_factor_alpha_activated_macrophages_of_the_transition_of_Paracoccidioides_brasiliensis_conidia_to_yeast_cells_through_a_mechanism_independent_of_nitric_oxide"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="27439944" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27439944/Short_Report_Inhibition_by_Tumor_Necrosis_Factor_%CE%91_Activated_Macrophages_of_the_Transition_of_Paracoccidioides_Brasiliensis_Conidia_to_Yeast_Cells_Through_a_Mechanism_Independent_of_Nitric_Oxide">Short Report: Inhibition by Tumor Necrosis Factor-Α–Activated Macrophages of the Transition of Paracoccidioides Brasiliensis Conidia to Yeast Cells Through a Mechanism Independent of Nitric Oxide</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34118682" href="https://independent.academia.edu/AngelaRestrepo2">Angela Restrepo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The American Journal of Tropical Medicine and Hygiene, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Short Report: Inhibition by Tumor Necrosis Factor-Α–Activated Macrophages of the Transition of Paracoccidioides Brasiliensis Conidia to Yeast Cells Through a Mechanism Independent of Nitric 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class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="12690148" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12690148/Production_of_Extracellular_Traps_against_Aspergillus_fumigatus_In_Vitro_and_in_Infected_Lung_Tissue_Is_Dependent_on_Invading_Neutrophils_and_Influenced_by_Hydrophobin_RodA">Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31702406" href="https://hki-jena.academia.edu/OlafKniemeyer">Olaf Kniemeyer</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLoS Pathogens, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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href="https://www.academia.edu/12690148/Production_of_Extracellular_Traps_against_Aspergillus_fumigatus_In_Vitro_and_in_Infected_Lung_Tissue_Is_Dependent_on_Invading_Neutrophils_and_Influenced_by_Hydrophobin_RodA"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="102138154" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/102138154/Paracoccidioides_brasiliensis_induces_secretion_of_IL_6_and_IL_8_by_lung_epithelial_cells_Modulation_of_host_cytokine_levels_by_fungal_proteases">Paracoccidioides brasiliensis induces secretion of IL-6 and IL-8 by lung epithelial cells. Modulation of host cytokine levels by fungal proteases</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="270643806" href="https://independent.academia.edu/MarcosAaronGirioToledo">Marcos Aaron Girio Toledo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Microbes and Infection, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Paracoccidioides brasiliensis induces secretion of IL-6 and IL-8 by lung epithelial cells. Modulation of host cytokine levels by fungal proteases","attachmentId":102481255,"attachmentType":"pdf","work_url":"https://www.academia.edu/102138154/Paracoccidioides_brasiliensis_induces_secretion_of_IL_6_and_IL_8_by_lung_epithelial_cells_Modulation_of_host_cytokine_levels_by_fungal_proteases","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/102138154/Paracoccidioides_brasiliensis_induces_secretion_of_IL_6_and_IL_8_by_lung_epithelial_cells_Modulation_of_host_cytokine_levels_by_fungal_proteases"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="27796292" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27796292/An_Extracellular_Matrix_Based_Mechanism_of_Rapid_Neutrophil_Extracellular_Trap_Formation_in_Response_to_Candida_albicans">An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52096825" href="https://independent.academia.edu/XianOBrien">Xian O'Brien</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Immunology, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans","attachmentId":48076657,"attachmentType":"pdf","work_url":"https://www.academia.edu/27796292/An_Extracellular_Matrix_Based_Mechanism_of_Rapid_Neutrophil_Extracellular_Trap_Formation_in_Response_to_Candida_albicans","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27796292/An_Extracellular_Matrix_Based_Mechanism_of_Rapid_Neutrophil_Extracellular_Trap_Formation_in_Response_to_Candida_albicans"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="85630120" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/85630120/Different_virulence_of_candida_albicans_is_attributed_to_the_ability_of_escape_from_neutrophil_extracellular_traps_by_secretion_of_DNase">Different virulence of candida albicans is attributed to the ability of escape from neutrophil extracellular traps by secretion of DNase</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="21724920" href="https://independent.academia.edu/QiaoWei1">Qiao Wei</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American journal of translational research, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Candida albicans is an important opportunistic fungus causing both disseminated and local infections. The discovery of neutrophil extracellular traps (NETs) has presented a new strategy to kill microorganisms in host&#39;s innate immune response. Although it has been reported that NETs can trap and kill both yeast and hyphal forms of C. albicans, the mechanism by which C. albicans escape from NETs has not been fully understood. In this study, the ability of two strains of C. albicans SC5314 and 3683 to escape NETs-mediated killing was compared. It was found that SC5314 induced higher levels of reactive oxygen species (ROS) and expressions of Rac1/2 and more NETs formation by neutrophils, and also generated more deoxyribonucleases (DNase) than 3683 did. However, resistance to neutrophils killing was greater in SC5314 than that of 3683. When extracellular traps were degraded by exogenous DNase I or catalase, and neutrophil phagocytic activity blocked by cytochalasin D, the killing cap...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Different virulence of candida albicans is attributed to the ability of escape from neutrophil extracellular traps by secretion of DNase","attachmentId":90269069,"attachmentType":"pdf","work_url":"https://www.academia.edu/85630120/Different_virulence_of_candida_albicans_is_attributed_to_the_ability_of_escape_from_neutrophil_extracellular_traps_by_secretion_of_DNase","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/85630120/Different_virulence_of_candida_albicans_is_attributed_to_the_ability_of_escape_from_neutrophil_extracellular_traps_by_secretion_of_DNase"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="12675174" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12675174/Alternative_Oxidase_Mediates_Pathogen_Resistance_in_Paracoccidioides_brasiliensis_Infection">Alternative Oxidase Mediates Pathogen Resistance in Paracoccidioides brasiliensis Infection</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31678026" href="https://udea.academia.edu/JuanMcEwen">Juan McEwen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLoS Neglected Tropical Diseases, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Alternative Oxidase Mediates Pathogen Resistance in Paracoccidioides brasiliensis Infection","attachmentId":46013035,"attachmentType":"pdf","work_url":"https://www.academia.edu/12675174/Alternative_Oxidase_Mediates_Pathogen_Resistance_in_Paracoccidioides_brasiliensis_Infection","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/12675174/Alternative_Oxidase_Mediates_Pathogen_Resistance_in_Paracoccidioides_brasiliensis_Infection"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="43308944" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/43308944/Paracoccidioides_brasiliensis_induces_cytokine_secretion_in_epithelial_cells_in_a_protease_activated_receptor_dependent_PAR_manner">Paracoccidioides brasiliensis induces cytokine secretion in epithelial cells in a protease-activated receptor-dependent (PAR) manner</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="160743395" href="https://unifesp.academia.edu/BiancaCarlaSilvaCampitellideBarros">Bianca Carla Silva Campitelli de Barros</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2017</p><p class="ds-related-work--abstract ds2-5-body-sm">fungal culture supernatants in a p-aminomethylbenzami-dine-Sepharose column. The obtained fractions were tested for enzymatic activity against fluorescence resonance energy transfer (FRET) peptides derived from sequences that spanned the activation sites of human PARs. The eluted fraction, termed PbP, contained protease activities that were able to hydrolyze the FRET peptides. PbP also induced IL-6 and IL-8 secretion in A549 epithelial cells, which was reduced upon heat inactivation of PbP, incubation with antagonistic peptides for PAR-1 and PAR-2, and the protease inhibitors aprotinin, leupeptin, and E-64. Together, these results show for the first time that P. bra-siliensis yeasts secrete proteases that activate PARs in lung epithelial cells, leading to cytokine secretion.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Paracoccidioides brasiliensis induces cytokine secretion in epithelial cells in a protease-activated receptor-dependent (PAR) manner","attachmentId":63589183,"attachmentType":"pdf","work_url":"https://www.academia.edu/43308944/Paracoccidioides_brasiliensis_induces_cytokine_secretion_in_epithelial_cells_in_a_protease_activated_receptor_dependent_PAR_manner","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/43308944/Paracoccidioides_brasiliensis_induces_cytokine_secretion_in_epithelial_cells_in_a_protease_activated_receptor_dependent_PAR_manner"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="53621668" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53621668/Candida_albicans_triggers_NADPH_oxidase_independent_neutrophil_extracellular_traps_through_dectin_2">Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="119271007" href="https://independent.academia.edu/HungWeiKan">Hung-Wei Kan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLOS Pathogens</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2","attachmentId":70381237,"attachmentType":"pdf","work_url":"https://www.academia.edu/53621668/Candida_albicans_triggers_NADPH_oxidase_independent_neutrophil_extracellular_traps_through_dectin_2","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53621668/Candida_albicans_triggers_NADPH_oxidase_independent_neutrophil_extracellular_traps_through_dectin_2"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="64644260" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64644260/Fungistatic_and_fungicidal_activities_of_murine_polymorphonuclear_leucocytes_against_yeast_cells_of_Paracoccidioides_brasiliensis">Fungistatic and fungicidal activities of murine polymorphonuclear leucocytes against yeast cells of Paracoccidioides brasiliensis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29286170" href="https://independent.academia.edu/AyakoSano">Ayako Sano</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medical Mycology, 2008</p><div 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You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="12655826" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/12655826/Cellular_Responses_of_Candida_albicans_to_Phagocytosis_and_the_Extracellular_Activities_of_Neutrophils_Are_Critical_to_Counteract_Carbohydrate_Starvation_Oxidative_and_Nitrosative_Stress">Cellular Responses of Candida albicans to Phagocytosis and the Extracellular Activities of Neutrophils Are Critical to Counteract Carbohydrate Starvation, Oxidative and Nitrosative Stress</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="18146619" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/18146619/Neutrophil_role_in_pulmonary_paracoccidioidomycosis_depends_on_the_resistance_pattern_of_hosts">Neutrophil role in pulmonary paracoccidioidomycosis depends on the resistance pattern of hosts</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34259843" href="https://fflch.academia.edu/VeraCalich">Vera Calich</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Leukocyte Biology, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neutrophil role in pulmonary 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class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27816541/High_efficiency_opsonin_independent_phagocytosis_of_Candida_parapsilosis_by_human_neutrophils">High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52079214" href="https://brown.academia.edu/JosephBliss">Joseph Bliss</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Medical Mycology, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils","attachmentId":48098986,"attachmentType":"pdf","work_url":"https://www.academia.edu/27816541/High_efficiency_opsonin_independent_phagocytosis_of_Candida_parapsilosis_by_human_neutrophils","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/27816541/High_efficiency_opsonin_independent_phagocytosis_of_Candida_parapsilosis_by_human_neutrophils"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="52670698" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title 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