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mw-first-heading"><span class="mw-page-title-main">Polynucleotide 5'-phosphatase</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. 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class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Polynucl%C3%A9otide_5%27-phosphatase" title="Polynucléotide 5'-phosphatase – French" lang="fr" hreflang="fr" data-title="Polynucléotide 5'-phosphatase" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%9D%E3%83%AA%E3%83%8C%E3%82%AF%E3%83%AC%E3%82%AA%E3%83%81%E3%83%89-5%27-%E3%83%9B%E3%82%B9%E3%83%95%E3%82%A1%E3%82%BF%E3%83%BC%E3%82%BC" title="ポリヌクレオチド-5'-ホスファターゼ – Japanese" lang="ja" hreflang="ja" data-title="ポリヌクレオチド-5'-ホスファターゼ" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Polinukleotidna_5%27-fosfataza" title="Polinukleotidna 5'-fosfataza – Serbian" lang="sr" hreflang="sr" data-title="Polinukleotidna 5'-fosfataza" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Polinukleotidna_5%27-fosfataza" title="Polinukleotidna 5'-fosfataza – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Polinukleotidna 5'-fosfataza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q7226660#sitelinks-wikipedia" title="Edit interlanguage links" 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<div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">polynucleotide 5′-phosphatase</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.enzyme-database.org/query.php?ec=3.1.3.33">3.1.3.33</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/CAS_registry_number" class="mw-redirect" title="CAS registry number">CAS no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=37288-17-8&title=">37288-17-8 </a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Databases</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=3.1.3.33">IntEnz view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.33">BRENDA entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/3.1.3.33">NiceZyme view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+3.1.3.33">KEGG entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&object=3.1.3.33">metabolic pathway</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PRIAM_enzyme-specific_profiles" title="PRIAM enzyme-specific profiles">PRIAM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=3.1.3.33">profile</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> structures</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:3.1.3.33">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:3.1.3.33">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=3.1.3.33">PDBsum</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004651">AmiGO </a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/term/GO:0004651">QuickGO</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.1.3.33%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=3.1.3.33%5BEC/RN%20Number%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=3.1.3.33%5BEC/RN%20Number%5D">proteins</a></td></tr></tbody></table></td></tr></tbody></table> <p>The enzyme <b>polynucleotide 5′-phosphatase</b> (<b>RNA 5′-triphosphatase</b>, <b>RTPase</b>, EC 3.1.3.33) is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that <a href="/wiki/Catalysis" title="Catalysis">catalyzes</a> the reaction </p> <dl><dd>a 5′-phosphopolynucleotide + H<sub>2</sub>O <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \rightleftharpoons }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mo class="MJX-variant" stretchy="false">⇌</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \rightleftharpoons }</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/1c37b981df851b9e54e489e017b1481e37d418f3" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:2.324ex; height:1.843ex;" alt="{\displaystyle \rightleftharpoons }"></span> a polynucleotide + phosphate</dd></dl> <p>This enzyme belongs to the family of <a href="/wiki/Hydrolase" title="Hydrolase">hydrolases</a>, specifically those acting on phosphoric <a href="/wiki/Ester" title="Ester">monoester</a> bonds. The <a href="/wiki/List_of_enzymes" title="List of enzymes">systematic name</a> is <b>polynucleotide 5′-phosphohydrolase</b>. This enzyme is also called <b>5′-polynucleotidase</b>. </p><p>The only specific molecular function known is the catalysis of the reaction: </p> <dl><dd>a 5′-end triphospho-(purine-ribonucleotide) in mRNA + H<sub>2</sub>O = a 5′-end diphospho-(purine-ribonucleoside) in mRNA + phosphate</dd></dl> <p>RTPases cleave the 5′-terminal γ-β phosphoanhydride bond of nascent <a href="/wiki/Messenger_RNA" title="Messenger RNA">messenger RNA</a> molecules, enabling the addition of a <a href="/wiki/Five-prime_cap" title="Five-prime cap">five-prime cap</a> as part of <a href="/wiki/Post-transcriptional_modification" title="Post-transcriptional modification">post-transcriptional modifications</a>. RTPases generate 5′-diphosphate-ended mRNA and a phosphate ion from 5′-triphosphate-ended <a href="/wiki/Precursor_mRNA" class="mw-redirect" title="Precursor mRNA">precursor mRNA</a>. <a href="/wiki/MRNA_guanylyltransferase" title="MRNA guanylyltransferase">mRNA guanylyltransferase</a> then adds a backwards <a href="/wiki/Guanosine_monophosphate" title="Guanosine monophosphate">guanosine monophosphate</a> (GMP) group from <a href="/wiki/Guanosine_triphosphate" title="Guanosine triphosphate">GTP</a>, generating <a href="/wiki/Pyrophosphate" title="Pyrophosphate">pyrophosphate</a>, and <a href="/wiki/MRNA_(guanine-N7-)-methyltransferase" title="MRNA (guanine-N7-)-methyltransferase">mRNA (guanine-N7-)-methyltransferase</a> methylates the <a href="/wiki/Guanine" title="Guanine">guanine</a> to form the final 5′-cap structure.<sup id="cite_ref-gross1998_1-0" class="reference"><a href="#cite_note-gross1998-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ho1998_2-0" class="reference"><a href="#cite_note-ho1998-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-takagi1997_4-0" class="reference"><a href="#cite_note-takagi1997-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-wen1998_5-0" class="reference"><a href="#cite_note-wen1998-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>There are two families of RTPases known so far: </p> <ul><li>the <b>metal-dependent</b> family. <a href="/wiki/Yeast" title="Yeast">Yeast</a>,<sup id="cite_ref-takagi1997_4-1" class="reference"><a href="#cite_note-takagi1997-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-bisaillon2003_6-0" class="reference"><a href="#cite_note-bisaillon2003-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-lima1999_7-0" class="reference"><a href="#cite_note-lima1999-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Protozoa" title="Protozoa">protozoan</a>, and <a href="/wiki/Virus" title="Virus">viral</a><sup id="cite_ref-takagi1997_4-2" class="reference"><a href="#cite_note-takagi1997-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-karpe2010_8-0" class="reference"><a href="#cite_note-karpe2010-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> RTPases require a <a href="/wiki/Cofactor_(biochemistry)#Metal_ions" title="Cofactor (biochemistry)">metal co-factor</a> for their activity, which is most often either Mg<sup>2+</sup> or Mn<sup>2+</sup>. This class of enzymes is also able to hydrolyze free <a href="/wiki/Nucleoside_triphosphate" title="Nucleoside triphosphate">nucleoside triphosphates</a> in the presence of either Mn<sup>2+</sup> or Co<sup>2+</sup>.<sup id="cite_ref-gross1998_1-1" class="reference"><a href="#cite_note-gross1998-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></li> <li>the <b>metal-independent</b> family. These groups do not require metals for their activity, and some enzymes have been shown to be inactivated in the presence of metal ions. These enzymes are very much similar to <a href="/wiki/Protein_tyrosine_phosphatase" title="Protein tyrosine phosphatase">protein tyrosine phosphatases</a> in their structure and mechanism.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> This family includes RTPases from mammals, plants, and other higher eukaryotes,<sup id="cite_ref-karpe2010_8-1" class="reference"><a href="#cite_note-karpe2010-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> and is structurally and mechanistically different from the metal-dependent RTPase family.<sup id="cite_ref-takagi1997_4-3" class="reference"><a href="#cite_note-takagi1997-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-wen1998_5-1" class="reference"><a href="#cite_note-wen1998-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-lima1999_7-1" class="reference"><a href="#cite_note-lima1999-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li></ul> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structural_studies">Structural studies</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Polynucleotide_5%27-phosphatase&action=edit&section=1" title="Edit section: Structural studies"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As of late 2007, 5 <a href="/wiki/Tertiary_structure" class="mw-redirect" title="Tertiary structure">structures</a> have been solved for this class of enzymes, with <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> accession codes <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1D8H">1D8H</a>, <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1D8I">1D8I</a>, <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1I9S">1I9S</a>, <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1I9T">1I9T</a>, and <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1YN9">1YN9</a>. </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Polynucleotide_5%27-phosphatase&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">Transcription (genetics)</a></li> <li><a href="/wiki/Five-prime_cap" title="Five-prime cap">Five-prime cap</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Polynucleotide_5%27-phosphatase&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-gross1998-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-gross1998_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-gross1998_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFGrossShuman1998" class="citation journal cs1">Gross CH, Shuman S (September 1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109926">"Characterization of a baculovirus-encoded RNA 5′-triphosphatase"</a>. <i>Journal of Virology</i>. <b>72</b> (9): 7057–63. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJVI.72.9.7057-7063.1998">10.1128/JVI.72.9.7057-7063.1998</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109926">109926</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9696798">9696798</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Characterization+of+a+baculovirus-encoded+RNA+5%E2%80%B2-triphosphatase&rft.volume=72&rft.issue=9&rft.pages=7057-63&rft.date=1998-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109926%23id-name%3DPMC&rft_id=info%3Apmid%2F9696798&rft_id=info%3Adoi%2F10.1128%2FJVI.72.9.7057-7063.1998&rft.aulast=Gross&rft.aufirst=CH&rft.au=Shuman%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109926&rfr_id=info%3Asid%2Fen.wikipedia.org%3APolynucleotide+5%27-phosphatase" class="Z3988"></span></span> </li> <li id="cite_note-ho1998-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-ho1998_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHoSchwerShuman1998" class="citation journal cs1">Ho CK, Schwer B, Shuman S (September 1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109104">"Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus"</a>. <i>Molecular and Cellular Biology</i>. <b>18</b> (9): 5189–98. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.18.9.5189">10.1128/MCB.18.9.5189</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109104">109104</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9710603">9710603</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Genetic%2C+physical%2C+and+functional+interactions+between+the+triphosphatase+and+guanylyltransferase+components+of+the+yeast+mRNA+capping+apparatus&rft.volume=18&rft.issue=9&rft.pages=5189-98&rft.date=1998-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109104%23id-name%3DPMC&rft_id=info%3Apmid%2F9710603&rft_id=info%3Adoi%2F10.1128%2FMCB.18.9.5189&rft.aulast=Ho&rft.aufirst=CK&rft.au=Schwer%2C+B&rft.au=Shuman%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109104&rfr_id=info%3Asid%2Fen.wikipedia.org%3APolynucleotide+5%27-phosphatase" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShuman2000" class="citation journal cs1">Shuman S (2000). "Structure, mechanism, and evolution of the mRNA capping apparatus". <i>Progress in Nucleic Acid Research and Molecular Biology</i>. <b>66</b>: 1–40. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0079-6603%2800%2966025-7">10.1016/s0079-6603(00)66025-7</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780125400664" title="Special:BookSources/9780125400664"><bdi>9780125400664</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11051760">11051760</a>.</cite><span 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id="CITEREFTakagiMooreDiehnBuratowski1997" class="citation journal cs1">Takagi T, Moore CR, Diehn F, Buratowski S (June 1997). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980272-X">"An RNA 5′-triphosphatase related to the protein tyrosine phosphatases"</a>. <i>Cell</i>. <b>89</b> (6): 867–73. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0092-8674%2800%2980272-X">10.1016/S0092-8674(00)80272-X</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9200605">9200605</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10484079">10484079</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=An+RNA+5%E2%80%B2-triphosphatase+related+to+the+protein+tyrosine+phosphatases&rft.volume=89&rft.issue=6&rft.pages=867-73&rft.date=1997-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10484079%23id-name%3DS2CID&rft_id=info%3Apmid%2F9200605&rft_id=info%3Adoi%2F10.1016%2FS0092-8674%2800%2980272-X&rft.aulast=Takagi&rft.aufirst=T&rft.au=Moore%2C+CR&rft.au=Diehn%2C+F&rft.au=Buratowski%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252FS0092-8674%252800%252980272-X&rfr_id=info%3Asid%2Fen.wikipedia.org%3APolynucleotide+5%27-phosphatase" class="Z3988"></span></span> </li> <li id="cite_note-wen1998-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-wen1998_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-wen1998_5-1"><sup><i><b>b</b></i></sup></a></span> <span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Human+PIR1+of+the+protein-tyrosine+phosphatase+superfamily+has+RNA+5%27-triphosphatase+and+diphosphatase+activities&rft.volume=274&rft.issue=23&rft.pages=16590-4&rft.date=1999-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.274.23.16590&rft_id=info%3Apmid%2F10347225&rft.aulast=Deshpande&rft.aufirst=T&rft.au=Takagi%2C+T&rft.au=Hao%2C+L&rft.au=Buratowski%2C+S&rft.au=Charbonneau%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.274.23.16590&rfr_id=info%3Asid%2Fen.wikipedia.org%3APolynucleotide+5%27-phosphatase" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Polynucleotide_5%27-phosphatase&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBeckerHurwitz1967" class="citation journal cs1">Becker A, Hurwitz J (March 1967). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2996215-0">"The enzymatic cleavage of phosphate termini from polynucleotides"</a>. <i>The Journal of Biological Chemistry</i>. <b>242</b> (5): 936–50. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2996215-0">10.1016/S0021-9258(18)96215-0</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/4289819">4289819</a>.</cite><span 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ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Esterases" title="Template:Esterases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Esterases" title="Template talk:Esterases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Esterases" title="Special:EditPage/Template:Esterases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Hydrolase:_esterases_(EC_3.1)" style="font-size:114%;margin:0 4em"><a href="/wiki/Hydrolase" title="Hydrolase">Hydrolase</a>: <a href="/wiki/Esterase" title="Esterase">esterases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 3.1)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.1:_Carboxylic_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.1</a>: <a href="/wiki/Carboxylic_acid" title="Carboxylic acid">Carboxylic</a><br />ester hydrolases</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a> <ul><li><a href="/wiki/Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a></li> <li><a href="/wiki/Butyrylcholinesterase" title="Butyrylcholinesterase">Butyrylcholinesterase</a></li></ul></li> <li><a href="/wiki/Pectinesterase" title="Pectinesterase">Pectinesterase</a></li> <li><a href="/wiki/6-phosphogluconolactonase" title="6-phosphogluconolactonase">6-phosphogluconolactonase</a></li> <li><a href="/wiki/PAF_acetylhydrolase" class="mw-redirect" title="PAF acetylhydrolase">PAF acetylhydrolase</a></li></ul> <ul><li><a href="/wiki/Lipase" title="Lipase">Lipase</a> <ul><li><a href="/wiki/Bile_salt-dependent_lipase" title="Bile salt-dependent lipase">Bile salt-dependent</a></li> <li><a href="/wiki/Gastric_lipase" title="Gastric lipase">Gastric</a>/<a href="/wiki/Lingual_lipase" title="Lingual lipase">Lingual</a></li> <li><a href="/wiki/Pancreatic_lipase" class="mw-redirect" title="Pancreatic lipase">Pancreatic</a></li> <li><a href="/wiki/Lysosomal_lipase" title="Lysosomal lipase">Lysosomal</a></li> <li><a href="/wiki/Hormone-sensitive_lipase" title="Hormone-sensitive lipase">Hormone-sensitive</a></li> <li><a href="/wiki/Endothelial_lipase" title="Endothelial lipase">Endothelial</a></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">Hepatic</a></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">Lipoprotein</a></li> <li><a href="/wiki/Monoacylglycerol_lipase" title="Monoacylglycerol lipase">Monoacylglycerol</a></li> <li><a href="/wiki/Diacylglycerol_lipase" title="Diacylglycerol lipase">Diacylglycerol</a></li></ul></li></ul> <ul><li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_A1" title="Phospholipase A1">A1</a></li> <li><a href="/wiki/Phospholipase_A2" title="Phospholipase A2">A2</a></li> <li><a href="/wiki/Phospholipase_B" title="Phospholipase B">B</a></li></ul></li></ul> <ul><li><a href="/wiki/Cutinase" title="Cutinase">Cutinase</a></li> <li><a href="/wiki/PETase" title="PETase">PETase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.2:_Thioester_Hydrolases" title="List of EC numbers (EC 3)">3.1.2</a>: <a href="/wiki/Thioesterase" title="Thioesterase">Thioesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Palmitoyl_protein_thioesterase" class="mw-redirect" title="Palmitoyl protein thioesterase">Palmitoyl protein thioesterase</a></li> <li><a href="/wiki/Ubiquitin_carboxy-terminal_hydrolase_L1" title="Ubiquitin carboxy-terminal hydrolase L1">Ubiquitin carboxy-terminal hydrolase L1</a></li> <li><a href="/wiki/4-hydroxybenzoyl-CoA_thioesterase" title="4-hydroxybenzoyl-CoA thioesterase">4-hydroxybenzoyl-CoA thioesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.3:_Phosphoric_Monoester_Hydrolases" title="List of EC numbers (EC 3)">3.1.3</a>: <a href="/wiki/Phosphatase" title="Phosphatase">Phosphatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alkaline_phosphatase" title="Alkaline phosphatase">Alkaline phosphatase</a> <ul><li><a href="/wiki/ALPI" title="ALPI">ALPI</a></li> <li><a href="/wiki/ALPL" title="ALPL">ALPL</a></li> <li><a href="/wiki/Placental_alkaline_phosphatase" class="mw-redirect" title="Placental alkaline phosphatase">ALPP</a></li></ul></li> <li><a href="/wiki/Acid_phosphatase" title="Acid phosphatase">Acid phosphatase</a> (<a href="/wiki/Prostatic_acid_phosphatase" title="Prostatic acid phosphatase">Prostatic</a>)/<a href="/wiki/Tartrate-resistant_acid_phosphatase" title="Tartrate-resistant acid phosphatase">Tartrate-resistant acid phosphatase</a>/<a href="/wiki/Purple_acid_phosphatases" title="Purple acid phosphatases">Purple acid phosphatases</a></li> <li><a href="/wiki/Nucleotidase" title="Nucleotidase">Nucleotidase</a></li> <li><a href="/wiki/Glucose_6-phosphatase" title="Glucose 6-phosphatase">Glucose 6-phosphatase</a></li> <li><a href="/wiki/Fructose_1,6-bisphosphatase" title="Fructose 1,6-bisphosphatase">Fructose 1,6-bisphosphatase</a> <ul><li><a href="/wiki/Calcineurin" title="Calcineurin">Calcineurin</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a> <ul><li><a href="/wiki/PP2A" class="mw-redirect" title="PP2A">PP2A</a></li></ul></li> <li><a href="/wiki/OCRL" title="OCRL">OCRL</a></li> <li><a href="/wiki/Pyruvate_dehydrogenase_phosphatase" title="Pyruvate dehydrogenase phosphatase">Pyruvate dehydrogenase phosphatase</a></li> <li><a href="/wiki/Phosphofructokinase_2" title="Phosphofructokinase 2">Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase</a></li> <li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a></li> <li><a href="/wiki/Phytase" title="Phytase">Phytase</a> <ul><li><a href="/wiki/Beta-propeller_phytase" title="Beta-propeller phytase">Beta-propeller phytase</a></li></ul></li> <li><a href="/wiki/Inositol-phosphate_phosphatase" title="Inositol-phosphate phosphatase">Inositol-phosphate phosphatase</a> <ul><li><a href="/wiki/Inositol_monophosphatase_1" title="Inositol monophosphatase 1">IMPA1</a>, <a href="/wiki/Inositol_monophosphatase_2" title="Inositol monophosphatase 2">IMPA2</a>, <a href="/wiki/Inositol_monophosphatase_3" title="Inositol monophosphatase 3">IMPA3</a></li></ul></li> <li><a href="/wiki/Protein_phosphatase" title="Protein phosphatase">Protein phosphatase</a>: <a href="/wiki/Protein_tyrosine_phosphatase" title="Protein tyrosine phosphatase">Protein tyrosine phosphatase</a></li> <li><a href="/wiki/Protein_serine/threonine_phosphatase" title="Protein serine/threonine phosphatase">Protein serine/threonine phosphatase</a></li> <li><a href="/wiki/Dual-specificity_phosphatase" title="Dual-specificity phosphatase">Dual-specificity phosphatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.4:_Phosphoric_Diester_Hydrolases" title="List of EC numbers (EC 3)">3.1.4</a>:<br /><a href="/wiki/Phosphodiesterase" title="Phosphodiesterase">Phosphodiesterase</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autotaxin" title="Autotaxin">Autotaxin</a></li> <li><a href="/wiki/Phospholipase" title="Phospholipase">Phospholipase</a> <ul><li><a href="/wiki/Phospholipase_C" title="Phospholipase C">C</a></li> <li><a href="/wiki/Phospholipase_D" title="Phospholipase D">D</a></li></ul></li> <li><a href="/wiki/Sphingomyelin_phosphodiesterase" title="Sphingomyelin phosphodiesterase">Sphingomyelin phosphodiesterase</a> <ul><li><a href="/wiki/Sphingomyelin_phosphodiesterase_1" title="Sphingomyelin phosphodiesterase 1">1</a></li></ul></li> <li><a href="/wiki/PDE1" title="PDE1">PDE1</a></li> <li><a href="/wiki/Phosphodiesterase_2" title="Phosphodiesterase 2">PDE2</a></li> <li><a href="/wiki/Phosphodiesterase_3" title="Phosphodiesterase 3">PDE3</a></li> <li><a href="/wiki/PDE4A" title="PDE4A">PDE4A</a>/<a href="/wiki/PDE4B" title="PDE4B">PDE4B</a></li> <li><a href="/wiki/CGMP-specific_phosphodiesterase_type_5" title="CGMP-specific phosphodiesterase type 5">PDE5</a></li> <li><a href="/wiki/Lecithinase" title="Lecithinase">Lecithinase</a> (<a href="/wiki/Clostridium_perfringens_alpha_toxin" title="Clostridium perfringens alpha toxin">Clostridium perfringens alpha toxin</a>)</li> <li><a href="/wiki/Cyclic_nucleotide_phosphodiesterase" title="Cyclic nucleotide phosphodiesterase">Cyclic nucleotide phosphodiesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.6:_Sulfuric_Ester_Hydrolases" title="List of EC numbers (EC 3)">3.1.6</a>: <a href="/wiki/Sulfatase" title="Sulfatase">Sulfatase</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Arylsulfatase" title="Arylsulfatase">arylsulfatase</a></i> <ul><li><a href="/wiki/Arylsulfatase_A" title="Arylsulfatase A">Arylsulfatase A</a></li> <li><a href="/wiki/Arylsulfatase_B" title="Arylsulfatase B">Arylsulfatase B</a></li> <li><a href="/wiki/Arylsulfatase_L" title="Arylsulfatase L">Arylsulfatase L</a></li> <li><a href="/wiki/Steroid_sulfatase" title="Steroid sulfatase">Steroid sulfatase</a></li></ul></li> <li><a href="/wiki/Galactosamine-6_sulfatase" title="Galactosamine-6 sulfatase">Galactosamine-6 sulfatase</a></li> <li><a href="/wiki/Iduronate-2-sulfatase" title="Iduronate-2-sulfatase">Iduronate-2-sulfatase</a></li> <li><a href="/wiki/N-acetylglucosamine-6-sulfatase" title="N-acetylglucosamine-6-sulfatase">N-acetylglucosamine-6-sulfatase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclease" title="Nuclease">Nuclease</a> (includes<br /><a href="/wiki/Deoxyribonuclease" title="Deoxyribonuclease">deoxyribonuclease</a><br />and <a href="/wiki/Ribonuclease" title="Ribonuclease">ribonuclease</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.11:_Exodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.11</a>-16:<br /><a href="/wiki/Exonuclease" title="Exonuclease">Exonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exodeoxyribonuclease" title="Exodeoxyribonuclease">Exodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RecBCD" title="RecBCD">RecBCD</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Exoribonuclease" title="Exoribonuclease">Exoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oligonucleotidase" title="Oligonucleotidase">Oligonucleotidase</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_3)#EC_3.1.21:_Endodeoxyribonucleases_Producing_5.27-Phosphomonoesters" title="List of EC numbers (EC 3)">3.1.21</a>-31:<br /><a href="/wiki/Endonuclease" title="Endonuclease">Endonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endodeoxyribonuclease" title="Endodeoxyribonuclease">Endodeoxyribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Deoxyribonuclease_I" title="Deoxyribonuclease I">Deoxyribonuclease I</a></li> <li><a href="/wiki/Deoxyribonuclease_II" title="Deoxyribonuclease II">Deoxyribonuclease II</a></li> <li><a href="/wiki/Deoxyribonuclease_IV" title="Deoxyribonuclease IV">Deoxyribonuclease IV</a></li> <li><a href="/wiki/Restriction_enzyme" title="Restriction enzyme">Restriction enzyme</a>;see <span class="nowrap">{{</span><a href="/wiki/Template:Restriction_enzyme" title="Template:Restriction enzyme">Restriction enzyme</a><span class="nowrap">}}</span></li> <li><a href="/wiki/UvrABC_endonuclease" title="UvrABC endonuclease">UvrABC endonuclease</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endoribonuclease" title="Endoribonuclease">Endoribonuclease</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RNase_III" class="mw-redirect" title="RNase III">RNase III</a> <ul><li><a href="/wiki/Drosha" title="Drosha">Drosha</a>: <a href="/wiki/Microprocessor_complex" title="Microprocessor complex">Microprocessor complex</a></li> <li><a href="/wiki/Dicer" title="Dicer">Dicer</a>: <a href="/wiki/RNA-induced_silencing_complex" title="RNA-induced silencing complex">RNA-induced silencing complex</a></li></ul></li> <li><a href="/wiki/RNase_H" class="mw-redirect" title="RNase H">RNase H</a> <ul><li><a href="/wiki/RNASEH1" title="RNASEH1">1</a></li> <li><a href="/wiki/RNASEH2A" title="RNASEH2A">2A</a></li> <li><a href="/wiki/RNASEH2B" title="RNASEH2B">2B</a></li> <li><a href="/wiki/RNASEH2C" title="RNASEH2C">2C</a></li></ul></li> <li><a href="/wiki/RNase_P" class="mw-redirect" title="RNase P">RNase P</a></li> <li><a href="/wiki/Ribonuclease_A" class="mw-redirect" title="Ribonuclease A">RNase A</a></li> <li><a href="/wiki/Ribonuclease_Z" title="Ribonuclease Z">RNase Z</a></li> <li><a href="/wiki/Ribonuclease_E" title="Ribonuclease E">RNase E</a> <ul><li><a href="/wiki/RNASE1" title="RNASE1">1</a></li> <li><a href="/wiki/Eosinophil-derived_neurotoxin" title="Eosinophil-derived neurotoxin">2</a></li> <li><a href="/wiki/Eosinophil_cationic_protein" title="Eosinophil cationic protein">3</a></li> <li><a href="/wiki/Angiogenin" title="Angiogenin">4/5</a></li></ul></li> <li><a href="/wiki/Ribonuclease_T1" title="Ribonuclease T1">RNase T1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">either deoxy- or ribo-    </th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclease_S1" title="Nuclease S1">Nuclease S1</a> <ul><li><a href="/wiki/Mung_bean_nuclease" title="Mung bean nuclease">Mung bean nuclease</a></li></ul></li> <li><a href="/wiki/Serratia_marcescens_nuclease" title="Serratia marcescens nuclease">Serratia marcescens nuclease</a></li> <li><a href="/wiki/Micrococcal_nuclease" title="Micrococcal nuclease">Micrococcal nuclease</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output 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