Hereditary ATTR Amyloidosis - Amyloidosis Research Consortium

<!doctype html> <html lang="en-US"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-RPFRKHTTFG"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-RPFRKHTTFG'); </script> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="profile" href="http://gmpg.org/xfn/11"> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>Hereditary ATTR Amyloidosis - Amyloidosis Research Consortium</title> <meta name="description" content="Hereditary ATTR amyloidosis is caused by a fault or mutation in the transthyretin (TTR) gene which is inherited i.e. runs in families. The mutation results in an abnormal TTR protein that is unstable and readily misfolds, forming aggregates which deposit as amyloid in various organs and tissues in the body." /> <link rel="canonical" href="https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Hereditary ATTR Amyloidosis - Amyloidosis Research Consortium" /> <meta property="og:description" content="Hereditary ATTR amyloidosis is caused by a fault or mutation in the transthyretin (TTR) gene which is inherited i.e. runs in families. The mutation results in an abnormal TTR protein that is unstable and readily misfolds, forming aggregates which deposit as amyloid in various organs and tissues in the body." /> <meta property="og:url" content="https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/" /> <meta property="og:site_name" content="Amyloidosis Research Consortium" /> <meta property="article:publisher" content="https://facebook.com/amyloidosisresearchconsortium" /> <meta property="article:modified_time" content="2024-02-23T17:35:10+00:00" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:site" content="@Amyloidosis_ARC" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/","url":"https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/","name":"Hereditary ATTR Amyloidosis - Amyloidosis Research Consortium","isPartOf":{"@id":"https://arci.org/#website"},"datePublished":"2018-04-27T16:31:45+00:00","dateModified":"2024-02-23T17:35:10+00:00","description":"Hereditary ATTR amyloidosis is caused by a fault or mutation in the transthyretin (TTR) gene which is inherited i.e. runs in families. The mutation results in an abnormal TTR protein that is unstable and readily misfolds, forming aggregates which deposit as amyloid in various organs and tissues in the body.","breadcrumb":{"@id":"https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/"]}]},{"@type":"BreadcrumbList","@id":"https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://arci.org/"},{"@type":"ListItem","position":2,"name":"About Amyloidosis","item":"https://arci.org/about-amyloidosis/"},{"@type":"ListItem","position":3,"name":"Hereditary ATTR Amyloidosis"}]},{"@type":"WebSite","@id":"https://arci.org/#website","url":"https://arci.org/","name":"Amyloidosis Research Consortium","description":"Amyloidosis Research Consortium","publisher":{"@id":"https://arci.org/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://arci.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https://arci.org/#organization","name":"Amyloidosis Research Consortium","url":"https://arci.org/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://arci.org/#/schema/logo/image/","url":"https://arci.org/wp-content/uploads/2019/02/ARC-logo.svg","contentUrl":"https://arci.org/wp-content/uploads/2019/02/ARC-logo.svg","width":1,"height":1,"caption":"Amyloidosis Research Consortium"},"image":{"@id":"https://arci.org/#/schema/logo/image/"},"sameAs":["https://facebook.com/amyloidosisresearchconsortium","https://x.com/Amyloidosis_ARC"]}]}</script>  <link rel='dns-prefetch' href='//maps.googleapis.com' /> <link rel='dns-prefetch' href='//cdnjs.cloudflare.com' /> <link rel='dns-prefetch' href='//maxcdn.bootstrapcdn.com' /> <link rel="alternate" type="application/rss+xml" title="Amyloidosis Research Consortium » Feed" href="https://arci.org/feed/" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/arci.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://arci.org/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='contact-form-7-css' href='https://arci.org/wp-content/plugins/contact-form-7/includes/css/styles.css?ver=6.0' type='text/css' media='all' /> <link rel='stylesheet' id='page-list-style-css' href='https://arci.org/wp-content/plugins/page-list/css/page-list.css?ver=5.7' type='text/css' media='all' /> <link rel='stylesheet' id='font-icons-css' href='https://maxcdn.bootstrapcdn.com/font-awesome/4.6.3/css/font-awesome.min.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='main-css-css' href='https://arci.org/wp-content/themes/arc/dist/css/style.min.css?ver=1732401430' type='text/css' media='all' /> <link rel='stylesheet' id='override-main-css-css' href='https://arci.org/wp-content/themes/arc/dist/css/style-override.min.css?ver=1732401430' type='text/css' media='all' /> <link rel='stylesheet' id='custom-css-css' href='https://arci.org/wp-content/themes/arc/arc-custom-styles.css?ver=1732401430' type='text/css' media='all' /> <script type="text/javascript" src="https://arci.org/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://arci.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <link rel="https://api.w.org/" href="https://arci.org/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://arci.org/wp-json/wp/v2/pages/1330" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://arci.org/xmlrpc.php?rsd" /> <link rel='shortlink' href='https://arci.org/?p=1330' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://arci.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Farci.org%2Fabout-amyloidosis%2Fhereditary-attr-amyloidosis%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://arci.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Farci.org%2Fabout-amyloidosis%2Fhereditary-attr-amyloidosis%2F&format=xml" /> <link rel="icon" href="https://arci.org/wp-content/uploads/2018/06/cropped-Favicon-32x32.png" sizes="32x32" /> <link rel="icon" href="https://arci.org/wp-content/uploads/2018/06/cropped-Favicon-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://arci.org/wp-content/uploads/2018/06/cropped-Favicon-180x180.png" /> <meta name="msapplication-TileImage" content="https://arci.org/wp-content/uploads/2018/06/cropped-Favicon-270x270.png" /> <style type="text/css" id="wp-custom-css"> /* You can add your own CSS here. Click the help icon above to learn more. */ .flourish-embed .embed-responsive-16by9:before { padding-bottom: 56.25%; } html > .embed-responsive-16by9:before { padding-top: 0 !important; } body.home > .embed-responsive-16by9:before { padding-top: 0 !important; } .wFormContainer .wForm form { padding: 0 !important; } .postid-3180 .read-more { visibility: hidden; } .grecaptcha-badge{display:none;} .page-template-template-page-builder .block-centre-text .gothem-light p { font-size: 18px;} .page-template-template-page-builder .block-centre-text .padding-text { padding: 0 1%; } .page-template-template-page-builder .block-centre-text h4 { margin-bottom: 30px; } h1 { line-height: 1.1; } li { padding-bottom: 6px; } #headline-navy { color: #093d5c; } .page-id-3836 .page-title .padding-header .page-template-template-page-builder { margin-bottom: 0px !important } .page-id-3836 .block-padding { margin-top: -30px !important} .page-id-3836 .site-content { padding-bottom: 0px; } .page-id-3836 .accordion-header {font-size: 23px !important;} strong {font-family: 'Gotham', Arial, sans-serif; font-weight: 500} .page-id-3836 .page-title h1 { visibility: hidden; } @media only screen and (min-width: 768px) { .page-id-3836 .page-title { padding: 142px 0; } } @media only screen and (min-width: 768px) { .page-id-3836 .page-title { padding: 165px 0; } } .page-id-1727 .main-accordion-title { font-size: 25px !important; text-align: center !important; } .page-id-1727 .block-content h2 { font-size: 25px !important; text-align: center !important; margin: 35px auto; } @media (min-width: 576px){ .page-id-3528 .page-title { padding: 160px 0; } } .page-id-3528 .page-title h1 { font-weight: bold; font-family: 'Gotham'; font-size: 68px; padding-right: 0px; } @media (max-width: 576px) { .page-id-3528 .page-title h1 { font-size: 28px; } } @media (min-width: 1500px) { .page-id-3528 .page-title { padding: 220px 0; } } </style> </head> <body class="page-template page-template-template-page-builder page-template-template-page-builder-php page page-id-1330 page-child parent-pageid-5184"> <div id="page" class="site"> <a class="skip-link screen-reader-text" href="#content">Skip to content</a> <header id="masthead" class="site-header"> <div class="container"> <div class="row"> <div class="col-sm-3 d-none d-sm-block"> <a class="navbar-brand" href="https://arci.org"> <img src="https://arci.org/wp-content/themes/arc/img/ARC-logo.svg" alt="logo" class="logo img-fluid" /> </a> </div> <div class="col-sm-9 mobile-no-marg"> <div class="top-row"> <div class="hamburger d-none d-sm-block d-lg-none"> <div class="d-none d-sm-block d-lg-none menu-text">Menu</div> <button class="navbar-toggler navbar-toggler-right collapsed" type="button" data-toggle="collapse" data-target="#bs4navbar"> <span> </span> <span> </span> <span> </span> </button> </div> <a class="donate d-none d-sm-block" href="https://donate.arci.org/give/602482/#!/donation/checkout" title="Donate" target="_blank">Donate</a> <div class="d-none d-sm-block"> <form role="search" method="get" class="search-form" action="https://arci.org/"> <label> <span class="screen-reader-text">Search for:</span> <input type="search" class="search-field" placeholder="Search …" value="" name="s" /> </label> <input type="submit" class="search-submit" value="Search" /> </form> </div> <div class="d-none d-lg-block"><div class="menu-top-menu-container"><ul id="menu-top-menu" class="menu"><li id="menu-item-948" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-948"><a href="https://arci.org/news/">News</a></li> <li id="menu-item-951" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-951"><a href="https://arci.org/events/">Events</a></li> </ul></div></div> </div> <nav class="navbar navbar-expand-lg navbar-light bg-faded"> <div class="d-block d-sm-none full-width"> <a class="navbar-brand" href="https://arci.org"> <img src="https://arci.org/wp-content/themes/arc/img/logo.png" alt="logo" class="logo img-fluid" /> </a> <div class="don-search"> <a href="https://arci.org/search/"> <img src="https://arci.org/wp-content/themes/arc/img/mag.jpg" alt="mag" class="mag-mobile img-fluid" /> </a> <a class="donate" href="https://donate.arci.org/give/602482/#!/donation/checkout" title="Donate" target="_blank"> Donate </a> </div> </div> <div class="d-block d-sm-none clear-mobile"> <div class="col-12 hamburger-mobile"> <button class="navbar-toggler navbar-toggler-right collapsed" type="button" data-toggle="collapse" data-target="#bs4navbar"> <span> </span> <span> </span> <span> </span> </button> <div class="menu-text">Menu</div> </div> </div> <div id="bs4navbar" class="collapse navbar-collapse"><ul id="menu-new_header" class="navbar-nav ml-auto"><li id="menu-item-5146" class="menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-5146 nav-item dropdown"><a class="nav-link">Amyloidosis & Types</a><button type="button" class="btn dropdown-toggle dropdown-toggle-split" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"><span class="sr-only">Toggle Dropdown</span></button> <div class="dropdown-menu"> <a href="https://arci.org/about-amyloidosis/" class=" dropdown-item">About Amyloidosis</a><a href="https://arci.org/about-amyloidosis/al-amyloidosis/" class=" dropdown-item">AL Amyloidosis</a><a href="https://arci.org/about-amyloidosis/hereditary-attr-amyloidosis/" class=" dropdown-item active">Hereditary ATTR Amyloidosis</a><a href="https://arci.org/about-amyloidosis/wild-type-amyloidosis/" class=" dropdown-item">Wild-Type Amyloidosis</a><a href="https://arci.org/about-amyloidosis/other-types-of-amyloidosis/" class=" dropdown-item">Other Types of Amyloidosis</a></div> </li> <li id="menu-item-5152" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-5152 nav-item dropdown"><a class="nav-link">Care & Support</a><button type="button" class="btn dropdown-toggle dropdown-toggle-split" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"><span class="sr-only">Toggle Dropdown</span></button> <div class="dropdown-menu"> <a href="https://arci.org/patients-and-caregivers/newly-diagnosed/" class=" dropdown-item">Newly Diagnosed</a><a href="https://arci.org/patient-resources/" class=" dropdown-item">Patient Resources</a><a href="https://arci.org/covid-19-and-amyloidosis/" class=" dropdown-item">COVID-19 & Amyloidosis</a><a href="https://arci.org/patients-and-caregivers/finding-support-2/" class=" dropdown-item">Finding Support</a><a href="https://arci.org/patients-and-caregivers/treatment-centers-clinical-trials/" class=" dropdown-item">Treatment Centers & Clinical Trials</a></div> </li> <li id="menu-item-5159" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-5159 nav-item dropdown"><a class="nav-link">Providers & Research</a><button type="button" class="btn dropdown-toggle dropdown-toggle-split" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"><span class="sr-only">Toggle Dropdown</span></button> <div class="dropdown-menu"> <a href="https://arci.org/the-amyloidosis-forum/" class=" dropdown-item">The Amyloidosis Forum</a><a href="https://arci.org/researchers-and-healthcare-professionals/research-programs/" class=" dropdown-item">Research Programs</a><a href="https://arci.org/researchers-and-healthcare-professionals/hcp-education/" class=" dropdown-item">HCP Education</a><a href="https://arci.org/researchers-and-healthcare-professionals/resources/" class=" dropdown-item">Resources</a><a href="https://arci.org/researchers-and-healthcare-professionals/resources/" class=" dropdown-item">Clinical Resource App</a><a href="https://arci.org/researchers-and-healthcare-professionals/industry/" class=" dropdown-item">Industry</a><a href="https://arci.org/treatment-availability/" class=" dropdown-item">Treatment Availability</a></div> </li> <li id="menu-item-5166" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-5166 nav-item dropdown"><a class="nav-link">Get Involved</a><button type="button" class="btn dropdown-toggle dropdown-toggle-split" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"><span class="sr-only">Toggle Dropdown</span></button> <div class="dropdown-menu"> <a href="https://arci.org/get-involved/" class=" dropdown-item">Ways to Get Involved</a><a href="https://arci.org/participate/" class=" dropdown-item">Participate in Research</a><a href="https://arci.org/donate/" class=" dropdown-item">Support ARC</a><a href="https://arci.org/participate/" class=" dropdown-item">Become an Advocate</a><a href="https://donate.arci.org/campaign/create-a-fundraiser/c177626" class=" dropdown-item">Create a Tribute or Fundraiser</a></div> </li> <li id="menu-item-5172" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-5172 nav-item dropdown"><a class="nav-link">About ARC</a><button type="button" class="btn dropdown-toggle dropdown-toggle-split" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"><span class="sr-only">Toggle Dropdown</span></button> <div class="dropdown-menu"> <a href="https://arci.org/about-arc/" class="last dropdown-item">What We Do</a><a href="https://arci.org/about-arc/leadership/" class=" dropdown-item">Leadership</a><a href="https://arci.org/about-arc/financial-reports/" class=" dropdown-item">Financials</a><a href="https://arci.org/news/" class=" dropdown-item">News</a><a href="https://arci.org/about-arc/careers/" class=" dropdown-item">Careers</a><a href="https://arci.org/about-arc/contact/" class=" dropdown-item">Contact Us</a></div> </li> <li id="menu-item-5179" class="hideDesktop menu-item menu-item-type-post_type menu-item-object-page menu-item-5179 nav-item"><a href="https://arci.org/news/" class="nav-link">News</a></li> <li id="menu-item-5180" class="hideDesktop menu-item menu-item-type-post_type menu-item-object-page menu-item-5180 nav-item"><a href="https://arci.org/events/" class="nav-link">Events</a></li> <li id="menu-item-5181" class="hideDesktop menu-item menu-item-type-post_type menu-item-object-page menu-item-5181 nav-item"><a href="https://arci.org/privacy/" class="nav-link">Privacy</a></li> </ul></div> </nav> </div> </div> </div> </header> <div id="content" class="site-content "> <div class="page-title "> <picture> <source media="(min-width: 767px)" srcset="https://arci.org/wp-content/uploads/2018/05/hATTR-header.png"> <img src="https://arci.org/wp-content/uploads/2018/05/hATTR-header.png" alt=""> </picture> <div class="container"> <h1>Hereditary ATTR Amyloidosis</h1> </div> </div> <div class="block-content block-padding" style="background-color: #fff"> <div class="container"> <div class="row"> <div class="col-md-7"> <h4 class="p1"><span class="s1">Hereditary ATTR (hATTR) amyloidosis is passed down through families.</span></h4> <p class="p1"><span class="s1">Hereditary ATTR amyloidosis is caused by a fault or mutation in the transthyretin (TTR) gene which is inherited (i.e. runs in families). The mutation results in an abnormal TTR protein that is unstable and readily misfolds, forming aggregates which deposit as amyloid in various organs and tissues in the body. TTR is mostly made in the liver. Its role is to transport the hormone thyroxine and retinol (Vitamin A) around the body, hence its name transthyretin.</span></p> <p><iframe src="https://www.youtube.com/embed/kg6b-2FL4Hg" width="640" height="360" frameborder="0" allowfullscreen="allowfullscreen"></iframe></p> <p>3D animated overview of ATTR amyloidosis</p> <p><b>Types of ATTR amyloidosis</b><br /> Two main types of ATTR amyloidosis exist:</p> <ul> <li><strong>Hereditary ATTR amyloidosis (hATTR)<br /> </strong>Caused by a faulty or mutated gene that is inherited, i.e. runs in the family</li> <li><strong>Wild-type ATTR amyloidosis (ATTRwt)</strong><br /> Develops with age; acquired not inherited<br /> <a href="/about-amyloidosis/wild-type-amyloidosis/">Learn more about wild-type ATTR</a></li> </ul> <p class="p1"><span class="s1">There are <b>over 120 different mutations</b> in the TTR gene but, as research continues, it is possible that more may be identified. Each different mutation causes a different pattern of disease onset, symptoms and outlook. The most common ATTR mutations are the:</span></p> <ul> <li><strong>ATTR V30M variant</strong> – found mostly in Portugal, Spain, France, Sweden, Japan and descendants of these regions</li> <li><strong>ATTR V122I variant</strong> – seen in 3-4% of African Americans</li> <li><strong>ATTR T60A variant</strong> – seen in people of Irish descent and the most common variant in the UK</li> </ul> <div class="contact-box"> <h5>Contact Our Specialist Team</h5> <p>We're here to help you.</p> <span href=""><i class="fa fa-phone" aria-hidden="true"></i> (617) 467-5170</span> <a href="mailto:support@arci.org"><i class="fa fa-envelope-o" aria-hidden="true"></i> support@arci.org</a> </div> <p> </p> </div> <div class="col-md-5 col-lg-4 offset-lg-1"> <p><a href="https://arci.org/resources-category/library/"><img fetchpriority="high" decoding="async" class="aligncenter wp-image-6210 size-full" src="https://arci.org/wp-content/uploads/2023/03/small-hattr-booklet-covers-new.png" alt="" width="650" height="457" srcset="https://arci.org/wp-content/uploads/2023/03/small-hattr-booklet-covers-new.png 650w, https://arci.org/wp-content/uploads/2023/03/small-hattr-booklet-covers-new-300x211.png 300w" sizes="(max-width: 650px) 100vw, 650px" /></a></p> <h5 style="text-align: center;">Hereditary ATTR (hATTR) Educational Booklets</h5> <p style="text-align: center;"><strong><a style="background-color: #8ec85a; padding: 1em 1.5em; text-align: center; color: #ffffff;" href="https://arci.org/resources-category/library/" rel="noopener">Download Here →</a></strong></p> <p> </p> <p> </p> <p><iframe src="https://www.youtube.com/embed/g28iIyA3BGs?si=x0Nd3rOA1Q_HLrgf" width="560" height="315" frameborder="0" allowfullscreen="allowfullscreen"></iframe><br /> Dawn describes her experience as a hereditary amyloidosis caregiver and patient, experiencing the onset of symptoms, her treatment journey, and advice for others living with hATTR amyloidosis.</p> <p> </p> <p><iframe loading="lazy" src="https://www.youtube.com/embed/IWQsMLkqzVg" width="560" height="315" frameborder="0" allowfullscreen="allowfullscreen"></iframe><br /> Sean Riley describes his symptoms, seven-year journey to diagnosis, undergoing bilateral carpal tunnel surgery, and advice for others living with hereditary ATTR amyloidosis.</p> <p> </p> <p><iframe loading="lazy" src="https://www.youtube.com/embed/dgdIfoRYxjE" width="560" height="315" frameborder="0" allowfullscreen="allowfullscreen"></iframe><br /> A patient’s experience living with hereditary amyloidosis</p> </div> </div> </div> </div> <div class="block-accordion block-padding"> <div class="container"> <div class="accordion-item"> <div class="accordion-header"> <div class="accordion-title">Symptoms</div> <div class="toggle-icon"> <span class="icon"></span> <span class="icon"></span> </div> </div> <div class="accordion-content"> <p class="p1"><span class="s1">Symptoms of hereditary ATTR amyloidosis vary depending on the genetic variant, the organs that have been affected, and the extent to which the amyloid deposits have caused damage. Symptoms can start at any time in adulthood. Common symptoms include:</span></p> <ul> <li class="p1"><span class="s3"><b>Cardiomyopathy</b> – Shortness of breath, palpitations and abnormal heart rhythm, ankle swelling (edema), fainting, fatigue, chest pain (angina)</span></li> <li class="p1"><span class="s3"><b>Peripheral neuropathy</b> – Tingling and numbness in legs and feet, difficulty walking, limb weakness and pain</span></li> <li class="p1"><span class="s3"><b>Autonomic neuropathy</b> – Light-headedness when standing (orthostatic hypotension), bladder problems, bowel problems, sexual dysfunction</span></li> <li class="p1"><span class="s3"><b>Gastrointestinal</b> – Decreased appetite, diarrhea, nausea, stomach pain, weight loss</span></li> </ul> <p> </p> <p class="p1"><span class="s1">Some ATTR variants are associated with specific symptoms. For example, the ATTR V30M variant typically causes symptoms associated with peripheral neuropathy, whereas the ATTR V122I variant typically causes symptoms associated with cardiomyopathy. Most patients, however, will have symptoms which indicate multiple organ involvement, regardless of what variant they have.</span></p> </div> </div> <div class="accordion-item"> <div class="accordion-header"> <div class="accordion-title">Diagnosis and Testing</div> <div class="toggle-icon"> <span class="icon"></span> <span class="icon"></span> </div> </div> <div class="accordion-content"> <p class="p1"><span class="s1">If ATTR amyloidosis is suspected, a number of tests are carried out including an abdominal fat pad biopsy to confirm the presence of amyloid deposits.</span></p> <p class="p1"><span class="s1">Tests are also done to determine the effect of the amyloid deposits on the heart, nerves and other organs. These tests include blood, nerve and muscle tests, echocardiogram, MRI and other types of scans. In some cases, organ biopsies may also be completed to determine organ involvement. Some scans can help identify the type of amyloidosis and distinguish ATTR from AL amyloidosis in the heart. Doctors also use other tests, called immunohistochemistry and mass spectrometry, to differentiate between ATTR and AL amyloidosis.</span></p> <p class="p1"><span class="s1">Hereditary ATTR amyloidosis is confirmed if a blood test shows a genetic mutation in the TTR gene. The test will be able to determine which variant it is. In such cases, it may be recommended for other members of the family to consider getting </span><span class="s2">genetic testing</span><span class="s1">.</span></p> </div> </div> <div class="accordion-item"> <div class="accordion-header"> <div class="accordion-title">Treatment</div> <div class="toggle-icon"> <span class="icon"></span> <span class="icon"></span> </div> </div> <div class="accordion-content"> <p>Up until recently, a liver transplant has been the only option for treatment of hereditary ATTR amyloidosis. TTR is mostly made by the liver and a transplant will reduce the production of the abnormal TTR protein.</p> <p>More recently, several drugs exist for the treatment of hATTR, some of which are still investigational and some of which are FDA approved. These treatments each have different therapeutic approaches and are aimed at:</p> <ol> <li>Stabilizing the TTR protein</li> <li>Stopping the production of TTR protein</li> <li>Removing the amyloid deposits</li> </ol> <p><strong>Stabilizing the TTR protein:</strong> The approach of TTR stabilizers is to stop the TTR protein from forming amyloid deposits.</p> <p>Drug status report:</p> <ul> <li>Diflunisal – Approved in the U.S. by the FDA as a non-steroidal, anti-inflammatory drug (NSAID) that has shown to bind to the TTR protein in the blood and may thereby prevent the formation of amyloid.</li> <li>Vyndaqel / Vyndamax (tafamidis) – Has been approved by the FDA in the U.S. for the treatment of transthyretin amyloidosis cardiomyopathy (ATTR-CM). Vyndaqel has also been approved in 41 countries outside of the U.S. to treat transthyretin amyloidosis polyneuropathy (ATTR-PN). <ul> <li>Vyndaqel / Vyndamax: <a href="https://arciorg.wpengine.com/wp-content/uploads/2019/05/Tafamidis-Infosheet_V2.pdf">view factsheet</a></li> </ul> </li> </ul> <p> </p> <p><strong>Stopping production of TTR:</strong> The approach in stopping production of TTR proteins is through ‘gene silencing’. Novel treatments known as “gene silencers” have shown promising results in clinical studies for patients with polyneuropathy. They prevent TTR protein production by blocking the TTR gene. These treatments have been approved for use for hATTR peripheral neuropathy.</p> <p>Drug factsheets:</p> <ul> <li>Patisiran (Onpattro) — <a href="https://arciorg.wpengine.com/wp-content/uploads/2018/11/Patisiran-Infosheet-V3-posted-Nov-1-.pdf" target="_blank" rel="noopener">view factsheet</a></li> <li>Inotersen (Tegsedi) — <a href="https://arciorg.wpengine.com/wp-content/uploads/2018/10/Tegsedi-Factsheet-v2.pdf" target="_blank" rel="noopener">view factsheet</a></li> <li>Vutrisiran (Amvuttra) — <a href="https://arci.org/wp-content/uploads/2022/06/Vutrisiran-Factsheet.pdf" target="_blank" rel="noopener">view factsheet</a></li> <li>Eplontersen (Wainua) — <a href="https://arci.org/wp-content/uploads/2024/01/Wainua-Eplontersen-Infosheet.pdf" target="_blank" rel="noopener">view factsheet</a></li> </ul> <p> </p> <p><strong>Removing amyloid deposits</strong></p> <p>There are currently no approved drugs aimed at removing amyloid deposits in hATTR.</p> <p>Drug status report:</p> <ul> <li>PRX004 – Currently being tested in clinical trials.</li> </ul> <p> </p> <p><strong>Supportive treatment</strong></p> <p>Although they do not address the underlying cause, supportive treatments are important to help alleviate symptoms and improve quality of life. Overall, factors such as age, general health and extent of organ damage are taken into account when deciding on treatment.</p> </div> </div> <div class="accordion-item"> <div class="accordion-header"> <div class="accordion-title">Treatment Centers and Clinical Trials</div> <div class="toggle-icon"> <span class="icon"></span> <span class="icon"></span> </div> </div> <div class="accordion-content"> <p class="p1"><span class="s1">Amyloidosis is a multi-system disease, meaning it affects multiple organs. It is important to be seen at a center that has experience in diagnosing and treating your type of amyloidosis. These centers will have a group of different specialists (i.e., cardiologist, hematologist, neurologist) who will be able to provide a comprehensive evaluation and treatment plan. Learn more about ARC’s treatment center finder MAP <a href="https://www.myamyloidosispathfinder.org/">here</a>.</span></p> <p class="p1"><span class="s1">Learning about clinical trials can be an important part of your care. In a rare disease such as amyloidosis, treatment options are often limited, and clinical trials may be the best way for you to access new therapies. To learn more about the basics of clinical trials, click <a href="https://arciorg.wpengine.com/patients-and-caregivers/treatment-centers-clinical-trials/">here</a>.</span></p> </div> </div> </div> </div> <div class="block-page-links block-padding"> <div class="container"> <div class="row no-wrap"> <div class="col-md-6 col-lg col-xl margin-bottom"> <a class="page-link-container" href="/al-amyloidosis/" style="background-color: #209298"> <div class="page-link-padding"> <div class="link-title"><b>AL<br>Amyloidosis</b></div> <div class="button-text">Find out more about AL amyloidosis</div> </div> </a> </div> <div class="col-md-6 col-lg col-xl margin-bottom"> <a class="page-link-container" href="/wild-type-amyloidosis/" style="background-color: #175b72"> <div class="page-link-padding"> <div class="link-title"><b>Wild-Type Amyloidosis</b></div> <div class="button-text">Find out more about wild-type amyloidosis</div> </div> </a> </div> <div class="col-md-6 col-lg col-xl margin-bottom"> <a class="page-link-container" href="/other-types-of-amyloidosis/" style="background-color: #36b9a1"> <div class="page-link-padding"> <div class="link-title"><b>Other Types of Amyloidosis</b></div> <div class="button-text">Find out more about other types of amyloidosis</div> </div> </a> </div> </div> </div> </div> </div> <script type="text/javascript" src="https://www.google.com/recaptcha/api.js?hl=en"></script> <footer id="colophon" class="site-footer"> <div class="container width-100sm"> <div class="row"> <div class="col-md-10 offset-md-1"> <div class="row">  <div class="col-sm-4 vert-line"> <a href="https://arci.org/events/" title="Events"> <img src="https://arci.org/wp-content/uploads/2024/07/Calendar-icon-orange.svg" alt="" /> <p class="titles"> Events </p> <p class="sub-text"> Check out upcoming conferences, webinars and fundraisers </p> </a> </div> <div class="col-sm-4 vert-line"> <a href="https://arci.org/patients-and-caregivers/treatment-centers-clinical-trials/" title="My Amyloidosis Pathfinder"> <img src="https://arci.org/wp-content/uploads/2018/06/Resources-icon.svg" alt="" /> <p class="titles"> My Amyloidosis Pathfinder </p> <p class="sub-text"> Find personalized treatment centers and clinical trials </p> </a> </div> <div class="col-sm-4 vert-line"> <a href="https://arci.org/researchers-and-healthcare-professionals/resources/" title="Resources"> <img src="https://arci.org/wp-content/uploads/2018/06/Publications-icon.svg" alt="" /> <p class="titles"> Resources </p> <p class="sub-text"> View ARC's library of resources and publications </p> </a> </div> </div> </div> </div> <div class="row newsletter"> <div class="col-12"> <p>Get the latest amyloidosis news and research from ARC.</p> <a href="https://arci.org/newsletter/" title="Join our newsletter">Join our newsletter</a> </div> </div> <div class="row socials"> <div class="col-12"> <ul> <li> <a href="https://www.facebook.com/amyloidosisresearchconsortium" target="_blank"> <i class="fa fa-facebook" aria-hidden="true"></i> </a> </li> <li> <a href="https://twitter.com/Amyloidosis_ARC" target="_blank"> <i class="fa fa-twitter" aria-hidden="true"></i> </a> </li> <li> <a href="https://www.youtube.com/channel/UCD_A4cq_YW4ggWTzlJygJvg" target="_blank"> <i class="fa fa-youtube" aria-hidden="true"></i> </a> </li> <li> <a href="mailto:arc@arci.org" title="email"> <i class="fa fa-envelope-o" aria-hidden="true"></i> </a> </li> </ul> </div> </div> </div> </footer> <div class="container footer2"> <div class="row"> <div class="col-12"> <img src="https://arci.org/wp-content/themes/arc/img/logo-footer.png" alt="" /> <div class="menu-footer-container"><ul id="menu-footer" class="menu"><li id="menu-item-1730" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1730"><a href="https://arci.org/donate/">Donate</a></li> <li id="menu-item-99" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-99"><a href="https://arci.org/privacy/">Privacy</a></li> </ul></div> <p class="uppercase">AMYLOIDOSIS RESEARCH CONSORTIUM, INC.<br> 320 Nevada Street, Suite 210 Newton, MA 02460 USA | 617-467-5170<br> <a href="mailto:arc@arci.org" title="email arc@arci.org">arc@arci.org</a></p> <p>ARC is a 501(c)(3) nonprofit organization. Tax ID: 47-2589708<br />©2024 ARC – Amyloidosis Research Consortium, Inc. All rights reserved. </p>  <a href="https://www.guidestar.org/profile/47-2589708" target="_blank"><img src="https://widgets.guidestar.org/TransparencySeal/9462745" alt="Guidestar Platinum Transparency 2023" /></a> <a href="https://greatnonprofits.org/org/amyloidosis-research-consortium-inc" target="_blank"><img src="https://arci.org/wp-content/themes/arc/img/2021-top-rated-awards-badge.png" alt="2021 Top Rated Great Non Profits" /></a> <a href="https://www.charitynavigator.org/ein/472589708" target="_blank" ><img src="https://arci.org/wp-content/themes/arc/img/four-star-rating-badge-charity-navigator.png" alt="Charity Navigator Four-Star Rating" /></a> </div> </div> </div> </div> <script type="text/javascript" src="https://arci.org/wp-includes/js/dist/hooks.min.js?ver=2810c76e705dd1a53b18" id="wp-hooks-js"></script> <script type="text/javascript" src="https://arci.org/wp-includes/js/dist/i18n.min.js?ver=5e580eb46a90c2b997e6" id="wp-i18n-js"></script> <script type="text/javascript" id="wp-i18n-js-after"> /* <![CDATA[ */ wp.i18n.setLocaleData( { 'text direction\u0004ltr': [ 'ltr' ] } ); /* ]]> */ </script> <script type="text/javascript" src="https://arci.org/wp-content/plugins/contact-form-7/includes/swv/js/index.js?ver=6.0" id="swv-js"></script> <script type="text/javascript" id="contact-form-7-js-before"> /* <![CDATA[ */ var wpcf7 = { "api": { "root": "https:\/\/arci.org\/wp-json\/", "namespace": "contact-form-7\/v1" }, "cached": 1 }; /* ]]> */ </script> <script type="text/javascript" src="https://arci.org/wp-content/plugins/contact-form-7/includes/js/index.js?ver=6.0" id="contact-form-7-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/themes/arc/js/navigation.js?ver=20151215" id="alan-navigation-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/themes/arc/js/skip-link-focus-fix.js?ver=20151215" id="alan-skip-link-focus-fix-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/themes/arc/js/jquery.matchHeight-min.js?ver=1.0" id="matchheights-js"></script> <script type="text/javascript" src="https://maps.googleapis.com/maps/api/js?key=AIzaSyCF1RAV3Sl3SWwBb3AHXXBPtgjKG1Uxlro&ver=1.0" id="google_maps-js"></script> <script type="text/javascript" src="https://cdnjs.cloudflare.com/ajax/libs/tether/1.4.0/js/tether.min.js?ver=1.0" id="tether-js-js"></script> <script type="text/javascript" src="https://maxcdn.bootstrapcdn.com/bootstrap/4.0.0/js/bootstrap.min.js?ver=1.0" id="bootstrap-js-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/themes/arc/js/main.min.js?ver=1.0" id="custom-scripts-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/themes/arc/js/arc-custom-scripts.js?ver=1.0" id="arc-custom-scripts-js"></script> <script type="text/javascript" src="https://arci.org/wp-content/plugins/page-links-to/dist/new-tab.js?ver=3.3.7" id="page-links-to-js"></script> <script type="text/javascript" src="https://www.google.com/recaptcha/api.js?render=6LcanacUAAAAAOdAYNusUAA1KtnZVVdF0-vYY5Ad&ver=3.0" id="google-recaptcha-js"></script> <script type="text/javascript" src="https://arci.org/wp-includes/js/dist/vendor/wp-polyfill.min.js?ver=3.15.0" id="wp-polyfill-js"></script> <script type="text/javascript" id="wpcf7-recaptcha-js-before"> /* <![CDATA[ */ var wpcf7_recaptcha = { "sitekey": "6LcanacUAAAAAOdAYNusUAA1KtnZVVdF0-vYY5Ad", "actions": { "homepage": "homepage", "contactform": "contactform" } }; /* ]]> */ </script> <script type="text/javascript" src="https://arci.org/wp-content/plugins/contact-form-7/modules/recaptcha/index.js?ver=6.0" id="wpcf7-recaptcha-js"></script>  <div class="modal fade" id="myModal" role="dialog"> <div class="modal-dialog">  <div class="modal-content"> <div class="modal-header" style="padding: 7px 14px 0px 0px;border-bottom:none;"> <button type="button" class="close" data-dismiss="modal">×</button> </div> <div class="modal-body"> <div class="newsletter-page"> <div class="container"> <div class=""> <div class=""> <div class="main-content"> <div class="" style="color:#093D5C;text-align: center;font-family:'Open Sans';font-size: 18px;font-weight: normal;line-height: 1.3;">Join our email list to stay up to date on the latest Amyloidosis news.</div> <style> .reqdFlag { color: #FF0000; margin-left: 3px; font-size: 18px; } input[type="text"] { width: 100%; padding: 6px 10px; margin: 2px 0; box-sizing: border-box; border: 2px solid #d0d0d0 !important; border-radius: 3px; } select { width: 100%; padding: 6px 10px; margin: 2px 0; box-sizing: border-box; border: 2px solid #d0d0d0 !important; border-radius: 3px; } td { padding-top: 10px; } .formFieldReqd { background-color: #ffcece; border-color: #ff0000; } </style> <script language="javascript"> function formVal(){ var reqdFieldCount = 4; var curFieldCount = 0; var reqFields = ['first_name','last_name','email','00N1I00000M2uS1']; var recaptcha_done = checkRecaptcha(); for(i=0; i<4; i++){ var thisFld = reqFields[i]; if(document.getElementById(thisFld).value != ''){ curFieldCount++; document.getElementById(thisFld).className = ''; }else{ document.getElementById(thisFld).className = 'formFieldReqd'; } } if(curFieldCount != reqdFieldCount){ alert('Please complete the required, highlighted fields. Thank you for your interest!'); return false; } else { if(recaptcha_done === false) { console.log('no recaptacha'); var recap = document.getElementById('g-recaptcha'); recap.classList.add('error'); return false; } else { return true; } } } function checkRecaptcha() { var response = grecaptcha.getResponse(); if(response.length == 0) { return false; } else { return true; } } function setRecaptcha() { var recap = document.getElementById('g-recaptcha'); recap.classList.remove('error'); } </script> <script> function timestamp() { var response = document.getElementById("g-recaptcha-response"); if (response == null || response.value.trim() == "") {var elems = JSON.parse(document.getElementsByName("captcha_settings")[0].value);elems["ts"] = JSON.stringify(new Date().getTime());document.getElementsByName("captcha_settings")[0].value = JSON.stringify(elems); } } setInterval(timestamp, 500); </script> <form action="https://webto.salesforce.com/servlet/servlet.WebToLead?encoding=UTF-8" method="POST" onsubmit="return formVal();"> <input type=hidden name="oid" value="00D1I000003Hb0C"> <input type=hidden name="retURL" value="https://arci.org/subscription-confirmation/"> <input type="hidden" id="lead_source" name="lead_source" value="Web"/> <input type="hidden" id="00N1I00000M2uS3" name="00N1I00000M2uS3" value="Newsletter Subscribe"/> <input type=hidden name='captcha_settings' value='{"keyname":"Google_Recaptcha_New","fallback":"true","orgId":"00D1I000003Hb0C","ts":""}'> <div class="formDiv"> <table align="center"> <tr> <td> <label for="first_name" class="formLabel">First Name</label><span class="formLabel reqdFlag">*</span><br/> <input id="first_name" maxlength="40" name="first_name" type="text" required="true" pattern=".*\S+.*" /><br> </td> </tr> <tr> <td> <label for="last_name" class="formLabel">Last Name</label><span class="formLabel reqdFlag">*</span><br/> <input id="last_name" maxlength="80" name="last_name" size="20" type="text" required="true" pattern=".*\S+.*" /><br> </td> </tr> <tr> <td> <label for="email" class="formLabel">Email</label><span class="formLabel reqdFlag">*</span><br/> <input id="email" maxlength="80" name="email" size="20" type="text" required="true" /><br> </td> </tr> <tr> <td> <label for="phone" class="formLabel">Phone</label><br/> <input id="phone" maxlength="80" name="phone" size="20" type="text" /><br> </td> </tr> <tr> <td> <label for="address" class="formLabel">Address</label><br/> <input id="address" maxlength="80" name="address" size="20" type="text" /><br> </td> </tr> <tr> <td> <label for="city" class="formLabel">City</label><br/> <input id="city" maxlength="80" name="city" size="20" type="text" /><br> </td> </tr> <tr> <td> <label for="zip" class="formLabel">Zip Code</label><br/> <input id="zip" maxlength="80" name="zip" size="20" type="text" /><br> </td> </tr> <tr> <td>  <label for="Lead_Category" class="formLabel">I am a</label><span class="formLabel reqdFlag">*</span> <br/> <select id="00N1I00000M2uS1" name="00N1I00000M2uS1" title="I am a" required="true"> <option value="">Please Select</option> <option value="Patient">Patient</option> <option value="Caregiver">Caregiver</option> <option value="Patient Family/Friend">Patient Family/Friend</option> <option value="Academic">Academic</option> <option value="Physician">Physician</option> <option value="Nurse">Nurse</option> <option value="Pharma">Pharma</option> <option value="ARC Supporter">ARC Supporter</option> </select> </td> </tr> <tr> <td> <div id="g-recaptcha" class="g-recaptcha" data-callback="setRecaptcha" data-sitekey="6LcECv0ZAAAAAEX3Cl8YzvDptAC7UR7fgaNp76ye"></div><br> <br> </td> </tr> <tr> <td> <input type="submit" name="submit" value="Subscribe" class="button inline-button" style="background-color: rgb(228, 91, 63);width: 100%;font-size: 14px;height: 38px;border: 1px solid #d1d1d1;padding: 0.625em 0.4375em;color: rgb(255, 255, 255);"> </td> </tr> </table> </div> </form> </div> </div> </div> </div> </div> </div> </div> </div> </div> </body> </html>

CINXE.COM

Hereditary ATTR Amyloidosis - Amyloidosis Research Consortium