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if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://ucsc.academia.edu/DavidDeamer","location":"/DavidDeamer","scheme":"https","host":"ucsc.academia.edu","port":null,"pathname":"/DavidDeamer","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-2d052b7a-b2f0-473a-8d76-55747f5a910a"></div> <div id="ProfileCheckPaperUpdate-react-component-2d052b7a-b2f0-473a-8d76-55747f5a910a"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="David Deamer" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/37974186/11532384/156203421/s200_david.deamer.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">David Deamer</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://ucsc.academia.edu/">University of California, Santa Cruz</a>, <a class="u-tcGrayDarker" href="https://ucsc.academia.edu/Departments/Biomolecular_Engineering/Documents">Biomolecular Engineering</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="David" data-follow-user-id="37974186" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="37974186"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">187</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">40</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">35</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">David Deamer is a Research Professor of Biomolecular Engineering at the University of California, Santa Cruz. Deamer received his undergraduate degree in Chemistry from Duke University in 1961, and PhD in Physiological Chemistry at the Ohio State University School of Medicine, 1965. Over his scientific career, Deamer has maintained a central focus on biological and synthetic membranes. In 1989, Deamer proposed the idea that it may be possible to sequence a DNA molecule by passing it through a nanoscopic pore embedded in a lipid bilayer membrane. Deamer, Daniel Branton, (Harvard University), and John Kasianowitz (NIST) demonstrated the feasibility of this concept in 1996. Collaborative work with Mark Akeson at UC Santa Cruz demonstrated proof of principle in 1999 when it was shown that a nanopore could distinguish between sequences of adenine and cytosine in RNA. In 2014, Oxford Nanopore Technology developed  and distributed the MinION device which utilizes nanopore sequencing concepts. In a second research area, Deamer investigates how primitive amphiphilic compounds could have encapsulated polymer systems to give rise to the first living cells. In 1985 he showed that lipid-like compounds in carbonaceous meteorites can self-assemble into membranous vesicles, making it plausible that such vesicles were present on the prebiotic Earth. Deamer was awarded a Guggenheim Fellowship in 1986 to work with Murchison meteorite samples at the Australian National University, Canberra. He is currently using nanopore biosensors to detect nucleic acid polymers synthesized in a robotic device that simulates prebiotic conditions. Deamer is the author or co-author of 300 research papers and review articles, and the author/editor of 12 books, including Origins of Life (2010), co-edited with Jack Szostak, and Assembling Life (2019) published by Oxford University Press.  His research has been featured in NOVA and National Geographic programs related to artificial life and the origin of life. He was elected to the National Academy of Inventors in 2023, and with his colleagues Branton and Akeson, was a recipient of the Golden Goose Award for inventing nanopore sequencing.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="37974186">View All (6)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="37974186" href="https://www.academia.edu/Documents/in/Hydrometallurgy"><div id="js-react-on-rails-context" style="display:none" 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data-dom-id="Pill-react-component-5cc8eeb4-1d19-406b-b35b-31aba3d3f684"></div> <div id="Pill-react-component-5cc8eeb4-1d19-406b-b35b-31aba3d3f684"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="37974186" href="https://www.academia.edu/Documents/in/Fluorescence_Microscopy"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Fluorescence Microscopy"]}" data-trace="false" data-dom-id="Pill-react-component-c681b608-55e9-4e92-b906-74b28b06d41d"></div> <div id="Pill-react-component-c681b608-55e9-4e92-b906-74b28b06d41d"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by David Deamer</h3></div><div class="js-work-strip profile--work_container" data-work-id="120981000"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120981000/The_potential_and_challenges_of_nanopore_sequencing"><img alt="Research paper thumbnail of The potential and challenges of nanopore sequencing" class="work-thumbnail" src="https://attachments.academia-assets.com/115966421/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120981000/The_potential_and_challenges_of_nanopore_sequencing">The potential and challenges of nanopore sequencing</a></div><div class="wp-workCard_item"><span>Co-Published with Macmillan Publishers Ltd, UK eBooks</span><span>, Aug 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A nanopore-based device provides single-molecule detection and analytical capabilities that are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility. Further research and development to overcome current challenges to nanopore identification of each successive nucleotide in a DNA strand offers the prospect of `third generation' instruments that will sequence a diploid mammalian genome for ~$1,000 in ~24 h.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2092fc1ece0b6d531bbcc74bc640c568" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115966421,"asset_id":120981000,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115966421/download_file?st=MTczNDQ5NzM0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120981000"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120981000"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120981000; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120981000]").text(description); $(".js-view-count[data-work-id=120981000]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120981000; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120981000']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120981000, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2092fc1ece0b6d531bbcc74bc640c568" } } $('.js-work-strip[data-work-id=120981000]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120981000,"title":"The potential and challenges of nanopore sequencing","translated_title":"","metadata":{"publisher":"Co-Published with Macmillan Publishers Ltd, UK","grobid_abstract":"A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120980990"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120980990/Hydrothermal_Chemistry_and_the_Origin_of_Cellular_Life"><img alt="Research paper thumbnail of Hydrothermal Chemistry and the Origin of Cellular Life" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120980990/Hydrothermal_Chemistry_and_the_Origin_of_Cellular_Life">Hydrothermal Chemistry and the Origin of Cellular Life</a></div><div class="wp-workCard_item"><span>Astrobiology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Two processes required for life&#39;s origin are condensation reactions that produce essential bi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Two processes required for life&#39;s origin are condensation reactions that produce essential biopolymers by a nonenzymatic reaction, and self-assembly of membranous compartments that encapsulate the polymers into populations of protocells. Because life today thrives not just in the temperate ocean and lakes but also in extreme conditions of temperature, salinity, and pH, there is a general assumption that any form of liquid water would be sufficient to support the origin of life as long as there are sources of chemical energy and simple organic compounds. We argue here that the first forms of life would be physically and chemically fragile and would be strongly affected by ionic solutes and pH. A hypothesis emerges from this statement that hot springs associated with volcanic land masses have an ionic composition more conducive to self-assembly and polymerization than seawater. Here we have compared the ionic solutes of seawater with those of terrestrial hot springs. 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the heart i f Nutwe being e\*el;v-n4ier.e music, $you ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Set1 deep enough, urd you see musically; the heart i f Nutwe being e\*el;v-n4ier.e music, $you can only r e a~h it.-Thoma\ Carlyle f we could hear the body, delve into its I rhythms and frequencies, what might it sound like'? Would we recognize patterns pleasing to the ear ... consider them beautiful ... musical? Is our biology harmonically ordered in any way'? And if so, so what? There are many ways to explore such questions, and one direct way is to access the frequencies of deoxyribonucleic acid (DNA), the primary carrier of genetic information for all living organisms. In 1988 the author, a composer, posed these questions to Dr. David Deamer, a cell biologist (now at UC Santa Cruz). Dr. Deamer is internationally known for his research on the origins of life. Some years before he had createdvery interesting music cassettes (DNA Suite and DNA Music) based on the mapping of sequences of bases in the double helix of DNA. He was intrigued and offered to help. One significant constraint with this project required that, rather than "mapping," or assigning arbitrary pitches to "hear" patterns, the actual vibrational frequencies were to be collected directly from the molecular realm. These frequencies would then be arranged as "scales" of tones and used as the basis for musical composition. Two years later, on April 22, 1990 (Earthday), the cassette version of "Sequencia" was recorded, and in 1994 the CD with additional music was produced. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45007540"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45007540/The_Hot_Spring_Hypothesis_for_an_Origin_of_Life"><img alt="Research paper thumbnail of The Hot Spring Hypothesis for an Origin of Life" class="work-thumbnail" src="https://attachments.academia-assets.com/65552614/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45007540/The_Hot_Spring_Hypothesis_for_an_Origin_of_Life">The Hot Spring Hypothesis for an Origin of Life</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ucolick.academia.edu/BruceDamer">Bruce Damer</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ucsc.academia.edu/DavidDeamer">David Deamer</a></span></div><div class="wp-workCard_item"><span>Astrobiology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We present a testable hypothesis related to an origin of life on land in which fluctuating volcan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We present a testable hypothesis related to an origin of life on land in which fluctuating volcanic hot spring pools play a central role. The hypothesis is based on experimental evidence that lipid-encapsulated polymers can be synthesized by cycles of hydration and dehydration to form protocells. Drawing on metaphors from the bootstrapping of a simple computer operating system, we show how protocells cycling through wet, dry, and moist phases will subject polymers to combinatorial selection and draw structural and catalytic functions out of initially random sequences, including structural stabilization, pore formation, and primitive metabolic activity. We propose that protocells aggregating into a hydrogel in the intermediate moist phase of wet-dry cycles represent a primitive progenote system. Progenote populations can undergo selection and distribution, construct niches in new environments, and enable a sharing network effect that can collectively evolve them into the first microbial communities. Laboratory and field experiments testing the first steps of the scenario are summarized. The scenario is then placed in a geological setting on the early Earth to suggest a plausible pathway from life's origin in chemically optimal freshwater hot spring pools to the emergence of microbial communities tolerant to more extreme conditions in dilute lakes and salty conditions in marine environments. A continuity is observed for biogenesis beginning with simple protocell aggregates, through the transitional form of the progenote, to robust microbial mats that leave the fossil imprints of stromatolites so representative in the rock record. A roadmap to future testing of the hypothesis is presented. We compare the oceanic vent with land-based pool scenarios for an origin of life and explore their implications for subsequent evolution to multicellular life such as plants. We conclude by utilizing the hypothesis to posit where life might also have emerged in habitats such as Mars or Saturn's icy moon Enceladus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5631caea6ea7257be2bf4924a5b0b24" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65552614,"asset_id":45007540,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65552614/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45007540"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45007540"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45007540; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45007540]").text(description); $(".js-view-count[data-work-id=45007540]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45007540; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45007540']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 45007540, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b5631caea6ea7257be2bf4924a5b0b24" } } $('.js-work-strip[data-work-id=45007540]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":45007540,"title":"The Hot Spring Hypothesis for an Origin of Life","translated_title":"","metadata":{"doi":"10.1089/ast.2019.2045","abstract":"We present a testable hypothesis related to an origin of life on land in which fluctuating volcanic hot spring pools play a central role. 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The hypothesis is based on experimental evidence that lipid-encapsulated polymers can be synthesized by cycles of hydration and dehydration to form protocells. Drawing on metaphors from the bootstrapping of a simple computer operating system, we show how protocells cycling through wet, dry, and moist phases will subject polymers to combinatorial selection and draw structural and catalytic functions out of initially random sequences, including structural stabilization, pore formation, and primitive metabolic activity. We propose that protocells aggregating into a hydrogel in the intermediate moist phase of wet-dry cycles represent a primitive progenote system. Progenote populations can undergo selection and distribution, construct niches in new environments, and enable a sharing network effect that can collectively evolve them into the first microbial communities. Laboratory and field experiments testing the first steps of the scenario are summarized. The scenario is then placed in a geological setting on the early Earth to suggest a plausible pathway from life's origin in chemically optimal freshwater hot spring pools to the emergence of microbial communities tolerant to more extreme conditions in dilute lakes and salty conditions in marine environments. A continuity is observed for biogenesis beginning with simple protocell aggregates, through the transitional form of the progenote, to robust microbial mats that leave the fossil imprints of stromatolites so representative in the rock record. A roadmap to future testing of the hypothesis is presented. We compare the oceanic vent with land-based pool scenarios for an origin of life and explore their implications for subsequent evolution to multicellular life such as plants. We conclude by utilizing the hypothesis to posit where life might also have emerged in habitats such as Mars or Saturn's icy moon Enceladus.","owner":{"id":37762328,"first_name":"Bruce","middle_initials":null,"last_name":"Damer","page_name":"BruceDamer","domain_name":"ucolick","created_at":"2015-11-05T23:34:18.058-08:00","display_name":"Bruce Damer","url":"https://ucolick.academia.edu/BruceDamer"},"attachments":[{"id":65552614,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/65552614/thumbnails/1.jpg","file_name":"2020_Damer_Deamer_HotSpringHypothesis_COVER_Astrobiology_2019.2045.pdf","download_url":"https://www.academia.edu/attachments/65552614/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Hot_Spring_Hypothesis_for_an_Origin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/65552614/2020_Damer_Deamer_HotSpringHypothesis_COVER_Astrobiology_2019.2045-libre.pdf?1611954419=\u0026response-content-disposition=attachment%3B+filename%3DThe_Hot_Spring_Hypothesis_for_an_Origin.pdf\u0026Expires=1734500944\u0026Signature=b9PLSaoLSRuO3OPbWeCZ1ovAYxPnnGx4-WKLHwgrEEzzZuZa83ziHantoPrE1qNMBQwabLfQX6RkaoYU-3veye5S9k2ZtFQAmf~fRubTWyz~nisY2GTLgty1r5lB4BQ7RKqRhRPd8L5KKvr8b0JCU18B5M3jeBnU317Adas~Db216LfHN0NmPBdHLhzfnU4vKhJxO5ZCrhuC79Otm3cIDWoZSJYFJjcoAlTutxQ2oWQ7HFqd50Bs5vaGpKGJTa5wdfbGNNXmLUo05f1-0zbyZpfWmFJXglXg34tw7ipv3VUpCzHhIxPiRancpWHaLmH29h~um2dFhMooX~vp4Me02Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4315,"name":"Origins of Life","url":"https://www.academia.edu/Documents/in/Origins_of_Life"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110971498"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110971498/THE_FORMATION_OF_GLYCEROL_MONODECANOATE_BY_A_DEHYDRATION_CONDENSATION_REACTION_INCREASING_THE_CHEMICAL_COMPLEXITY_OF_AMPHIPHILES_ON_THE_EARLY_EARTH_Chemical_Evolution_International_Symposium_on_Origins_of_Life_and_Astrobiology_"><img alt="Research paper thumbnail of THE FORMATION OF GLYCEROL MONODECANOATE BY A DEHYDRATION/CONDENSATION REACTION : INCREASING THE CHEMICAL COMPLEXITY OF AMPHIPHILES ON THE EARLY EARTH(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)" class="work-thumbnail" src="https://attachments.academia-assets.com/108622980/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110971498/THE_FORMATION_OF_GLYCEROL_MONODECANOATE_BY_A_DEHYDRATION_CONDENSATION_REACTION_INCREASING_THE_CHEMICAL_COMPLEXITY_OF_AMPHIPHILES_ON_THE_EARLY_EARTH_Chemical_Evolution_International_Symposium_on_Origins_of_Life_and_Astrobiology_">THE FORMATION OF GLYCEROL MONODECANOATE BY A DEHYDRATION/CONDENSATION REACTION : INCREASING THE CHEMICAL COMPLEXITY OF AMPHIPHILES ON THE EARLY EARTH(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)</a></div><div class="wp-workCard_item"><span>Viva origino</span><span>, Aug 10, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dehydration/condensation reactions between organic molecules in the prebiotic environment increas...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dehydration/condensation reactions between organic molecules in the prebiotic environment increased the inventory and complexity of organic compounds available for self-assembly into primitive cellular organisms. As a model of such reactions and to demonstrate this principle, we have investigated the esterification reaction between glycerol and decanoic acid that forms glycerol monodecanoate (GMD). This amphiphile enhances robustness of self-assembled membranous structures of carboxylic acids to the potentially disruptive effects of pH, divalent cation binding and osmotic stress. Experimental variables included temperature, water activity and hydrolysis of the resulting ester product, providing insights into the environmental conditions that would favor the formation and stability of this more evolved amphiphile. At temperatures exceeding 50 • C, the ester product formed even in the presence of bulk water, suggesting that the reaction occurs at the liquid interface of the two reactants and that the products segregate in the two immiscible layers, thereby reducing hydrolytic back reactions. This implies that esterification reactions were likely to be common in the prebiotic environment as reactants underwent cycles of wetting and drying on rare early landmasses at elevated temperatures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="597233d23948e3e5a380f930e5a5a9eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108622980,"asset_id":110971498,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108622980/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110971498"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110971498"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110971498; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110971498]").text(description); $(".js-view-count[data-work-id=110971498]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110971498; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110971498']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110971498, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "597233d23948e3e5a380f930e5a5a9eb" } } $('.js-work-strip[data-work-id=110971498]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110971498,"title":"THE FORMATION OF GLYCEROL MONODECANOATE BY A DEHYDRATION/CONDENSATION REACTION : INCREASING THE CHEMICAL COMPLEXITY OF AMPHIPHILES ON THE EARLY EARTH(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)","translated_title":"","metadata":{"grobid_abstract":"Dehydration/condensation reactions between organic molecules in the prebiotic environment increased the inventory and complexity of organic compounds available for self-assembly into primitive cellular organisms. 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The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility. Further research and development to overcome current challenges to nanopore identification of each successive nucleotide in a DNA strand offers the prospect of `third generation' instruments that will sequence a diploid mammalian genome for ~$1,000 in ~24 h.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16ee2e6d993e4f9c4764f7c1124ef9d4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108622933,"asset_id":110971493,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108622933/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110971493"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110971493"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110971493; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110971493]").text(description); $(".js-view-count[data-work-id=110971493]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110971493; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110971493']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110971493, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16ee2e6d993e4f9c4764f7c1124ef9d4" } } $('.js-work-strip[data-work-id=110971493]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110971493,"title":"The potential and challenges of nanopore sequencing","translated_title":"","metadata":{"publisher":"University of North Carolina at Chapel Hill","grobid_abstract":"A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. 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Schmidt, W. Vercoutere, D. Deamer, A.R. Hawkins, R. C. Quinn, A. S. Burton, and C. P. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">waters, H. Schmidt, W. Vercoutere, D. Deamer, A.R. Hawkins, R. C. Quinn, A. S. Burton, and C. P. 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The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120980984"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120980984/The_infrared_frequencies_of_DNA_bases_science_and_art"><img alt="Research paper thumbnail of The infrared frequencies of DNA bases: science and art" class="work-thumbnail" src="https://attachments.academia-assets.com/115966429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120980984/The_infrared_frequencies_of_DNA_bases_science_and_art">The infrared frequencies of DNA bases: science and art</a></div><div class="wp-workCard_item"><span>IEEE Engineering in Medicine and Biology Magazine</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Set1 deep enough, urd you see musically; the heart i f Nutwe being e\*el;v-n4ier.e music, $you ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Set1 deep enough, urd you see musically; the heart i f Nutwe being e\*el;v-n4ier.e music, $you can only r e a~h it.-Thoma\ Carlyle f we could hear the body, delve into its I rhythms and frequencies, what might it sound like'? Would we recognize patterns pleasing to the ear ... consider them beautiful ... musical? Is our biology harmonically ordered in any way'? And if so, so what? There are many ways to explore such questions, and one direct way is to access the frequencies of deoxyribonucleic acid (DNA), the primary carrier of genetic information for all living organisms. In 1988 the author, a composer, posed these questions to Dr. David Deamer, a cell biologist (now at UC Santa Cruz). Dr. Deamer is internationally known for his research on the origins of life. Some years before he had createdvery interesting music cassettes (DNA Suite and DNA Music) based on the mapping of sequences of bases in the double helix of DNA. He was intrigued and offered to help. One significant constraint with this project required that, rather than "mapping," or assigning arbitrary pitches to "hear" patterns, the actual vibrational frequencies were to be collected directly from the molecular realm. These frequencies would then be arranged as "scales" of tones and used as the basis for musical composition. Two years later, on April 22, 1990 (Earthday), the cassette version of "Sequencia" was recorded, and in 1994 the CD with additional music was produced. Sequenciu consists of three performances of original mus i c-"E i k o s , " " S e q ue n c i a , " a n d "Pataphysical Thymine"-performed on traditional instruments plus electronic keyboard, based entirely on a tuning system derived from certain frequencies that occur naturally in DNA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b859cf7892b0d3ef51423a61deda0c33" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115966429,"asset_id":120980984,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115966429/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120980984"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120980984"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120980984; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120980984]").text(description); $(".js-view-count[data-work-id=120980984]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120980984; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120980984']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120980984, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b859cf7892b0d3ef51423a61deda0c33" } } $('.js-work-strip[data-work-id=120980984]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120980984,"title":"The infrared frequencies of DNA bases: science and art","translated_title":"","metadata":{"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","ai_title_tag":"Exploring DNA Frequencies through Musical Composition","grobid_abstract":"Set1 deep enough, urd you see musically; the heart i f Nutwe being e\\*el;v-n4ier.e music, $you can only r e a~h it.-Thoma\\ Carlyle f we could hear the body, delve into its I rhythms and frequencies, what might it sound like'? Would we recognize patterns pleasing to the ear ... consider them beautiful ... musical? Is our biology harmonically ordered in any way'? And if so, so what? There are many ways to explore such questions, and one direct way is to access the frequencies of deoxyribonucleic acid (DNA), the primary carrier of genetic information for all living organisms. In 1988 the author, a composer, posed these questions to Dr. David Deamer, a cell biologist (now at UC Santa Cruz). Dr. Deamer is internationally known for his research on the origins of life. Some years before he had createdvery interesting music cassettes (DNA Suite and DNA Music) based on the mapping of sequences of bases in the double helix of DNA. He was intrigued and offered to help. One significant constraint with this project required that, rather than \"mapping,\" or assigning arbitrary pitches to \"hear\" patterns, the actual vibrational frequencies were to be collected directly from the molecular realm. 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Would we recognize patterns pleasing to the ear ... consider them beautiful ... musical? Is our biology harmonically ordered in any way'? And if so, so what? There are many ways to explore such questions, and one direct way is to access the frequencies of deoxyribonucleic acid (DNA), the primary carrier of genetic information for all living organisms. In 1988 the author, a composer, posed these questions to Dr. David Deamer, a cell biologist (now at UC Santa Cruz). Dr. Deamer is internationally known for his research on the origins of life. Some years before he had createdvery interesting music cassettes (DNA Suite and DNA Music) based on the mapping of sequences of bases in the double helix of DNA. He was intrigued and offered to help. One significant constraint with this project required that, rather than \"mapping,\" or assigning arbitrary pitches to \"hear\" patterns, the actual vibrational frequencies were to be collected directly from the molecular realm. These frequencies would then be arranged as \"scales\" of tones and used as the basis for musical composition. Two years later, on April 22, 1990 (Earthday), the cassette version of \"Sequencia\" was recorded, and in 1994 the CD with additional music was produced. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120980904"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120980904/Urability_A_Property_of_Planetary_Bodies_That_Can_Support_an_Origin_of_Life"><img alt="Research paper thumbnail of Urability: A Property of Planetary Bodies That Can Support an Origin of Life" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/120980904/Urability_A_Property_of_Planetary_Bodies_That_Can_Support_an_Origin_of_Life">Urability: A Property of Planetary Bodies That Can Support an Origin of Life</a></div><div class="wp-workCard_item"><span>Astrobiology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120980904"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120980904"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120980904; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120980904]").text(description); $(".js-view-count[data-work-id=120980904]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120980904; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120980904']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120980904, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120980904]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120980904,"title":"Urability: A Property of Planetary Bodies That Can Support an Origin of Life","translated_title":"","metadata":{"publisher":"Mary Ann Liebert Inc","publication_name":"Astrobiology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/120980904/Urability_A_Property_of_Planetary_Bodies_That_Can_Support_an_Origin_of_Life","translated_internal_url":"","created_at":"2024-06-13T14:05:46.105-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":37974186,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Urability_A_Property_of_Planetary_Bodies_That_Can_Support_an_Origin_of_Life","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":null,"owner":{"id":37974186,"first_name":"David","middle_initials":null,"last_name":"Deamer","page_name":"DavidDeamer","domain_name":"ucsc","created_at":"2015-11-09T12:22:17.487-08:00","display_name":"David Deamer","url":"https://ucsc.academia.edu/DavidDeamer"},"attachments":[],"research_interests":[{"id":406,"name":"Geology","url":"https://www.academia.edu/Documents/in/Geology"},{"id":407,"name":"Geochemistry","url":"https://www.academia.edu/Documents/in/Geochemistry"},{"id":5001,"name":"Astrobiology","url":"https://www.academia.edu/Documents/in/Astrobiology"},{"id":14193,"name":"Philosophy of Property","url":"https://www.academia.edu/Documents/in/Philosophy_of_Property"},{"id":235999,"name":"Exoplanet","url":"https://www.academia.edu/Documents/in/Exoplanet"},{"id":268407,"name":"Planet","url":"https://www.academia.edu/Documents/in/Planet"},{"id":309434,"name":"Solar System","url":"https://www.academia.edu/Documents/in/Solar_System"},{"id":406486,"name":"Habitability","url":"https://www.academia.edu/Documents/in/Habitability"},{"id":969355,"name":"Abiogenesis","url":"https://www.academia.edu/Documents/in/Abiogenesis"}],"urls":[{"id":42915433,"url":"https://www.liebertpub.com/doi/pdf/10.1089/ast.2021.0173"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="45007540"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/45007540/The_Hot_Spring_Hypothesis_for_an_Origin_of_Life"><img alt="Research paper thumbnail of The Hot Spring Hypothesis for an Origin of Life" class="work-thumbnail" src="https://attachments.academia-assets.com/65552614/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/45007540/The_Hot_Spring_Hypothesis_for_an_Origin_of_Life">The Hot Spring Hypothesis for an Origin of Life</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://ucolick.academia.edu/BruceDamer">Bruce Damer</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ucsc.academia.edu/DavidDeamer">David Deamer</a></span></div><div class="wp-workCard_item"><span>Astrobiology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We present a testable hypothesis related to an origin of life on land in which fluctuating volcan...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We present a testable hypothesis related to an origin of life on land in which fluctuating volcanic hot spring pools play a central role. The hypothesis is based on experimental evidence that lipid-encapsulated polymers can be synthesized by cycles of hydration and dehydration to form protocells. Drawing on metaphors from the bootstrapping of a simple computer operating system, we show how protocells cycling through wet, dry, and moist phases will subject polymers to combinatorial selection and draw structural and catalytic functions out of initially random sequences, including structural stabilization, pore formation, and primitive metabolic activity. We propose that protocells aggregating into a hydrogel in the intermediate moist phase of wet-dry cycles represent a primitive progenote system. Progenote populations can undergo selection and distribution, construct niches in new environments, and enable a sharing network effect that can collectively evolve them into the first microbial communities. Laboratory and field experiments testing the first steps of the scenario are summarized. The scenario is then placed in a geological setting on the early Earth to suggest a plausible pathway from life's origin in chemically optimal freshwater hot spring pools to the emergence of microbial communities tolerant to more extreme conditions in dilute lakes and salty conditions in marine environments. A continuity is observed for biogenesis beginning with simple protocell aggregates, through the transitional form of the progenote, to robust microbial mats that leave the fossil imprints of stromatolites so representative in the rock record. A roadmap to future testing of the hypothesis is presented. We compare the oceanic vent with land-based pool scenarios for an origin of life and explore their implications for subsequent evolution to multicellular life such as plants. We conclude by utilizing the hypothesis to posit where life might also have emerged in habitats such as Mars or Saturn's icy moon Enceladus.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5631caea6ea7257be2bf4924a5b0b24" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":65552614,"asset_id":45007540,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/65552614/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="45007540"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="45007540"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 45007540; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=45007540]").text(description); $(".js-view-count[data-work-id=45007540]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 45007540; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='45007540']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 45007540, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b5631caea6ea7257be2bf4924a5b0b24" } } $('.js-work-strip[data-work-id=45007540]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":45007540,"title":"The Hot Spring Hypothesis for an Origin of Life","translated_title":"","metadata":{"doi":"10.1089/ast.2019.2045","abstract":"We present a testable hypothesis related to an origin of life on land in which fluctuating volcanic hot spring pools play a central role. 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As a model of such reactions and to demonstrate this principle, we have investigated the esterification reaction between glycerol and decanoic acid that forms glycerol monodecanoate (GMD). This amphiphile enhances robustness of self-assembled membranous structures of carboxylic acids to the potentially disruptive effects of pH, divalent cation binding and osmotic stress. Experimental variables included temperature, water activity and hydrolysis of the resulting ester product, providing insights into the environmental conditions that would favor the formation and stability of this more evolved amphiphile. At temperatures exceeding 50 • C, the ester product formed even in the presence of bulk water, suggesting that the reaction occurs at the liquid interface of the two reactants and that the products segregate in the two immiscible layers, thereby reducing hydrolytic back reactions. This implies that esterification reactions were likely to be common in the prebiotic environment as reactants underwent cycles of wetting and drying on rare early landmasses at elevated temperatures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="597233d23948e3e5a380f930e5a5a9eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108622980,"asset_id":110971498,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108622980/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110971498"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110971498"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110971498; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110971498]").text(description); $(".js-view-count[data-work-id=110971498]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110971498; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110971498']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110971498, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "597233d23948e3e5a380f930e5a5a9eb" } } $('.js-work-strip[data-work-id=110971498]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110971498,"title":"THE FORMATION OF GLYCEROL MONODECANOATE BY A DEHYDRATION/CONDENSATION REACTION : INCREASING THE CHEMICAL COMPLEXITY OF AMPHIPHILES ON THE EARLY EARTH(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)","translated_title":"","metadata":{"grobid_abstract":"Dehydration/condensation reactions between organic molecules in the prebiotic environment increased the inventory and complexity of organic compounds available for self-assembly into primitive cellular organisms. 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This implies that esterification reactions were likely to be common in the prebiotic environment as reactants underwent cycles of wetting and drying on rare early landmasses at elevated temperatures.","owner":{"id":37974186,"first_name":"David","middle_initials":null,"last_name":"Deamer","page_name":"DavidDeamer","domain_name":"ucsc","created_at":"2015-11-09T12:22:17.487-08:00","display_name":"David Deamer","url":"https://ucsc.academia.edu/DavidDeamer"},"attachments":[{"id":108622980,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108622980/thumbnails/1.jpg","file_name":"s11084-005-2046-820231209-1-5suh9u.pdf","download_url":"https://www.academia.edu/attachments/108622980/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"THE_FORMATION_OF_GLYCEROL_MONODECANOATE.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108622980/s11084-005-2046-820231209-1-5suh9u-libre.pdf?1702172840=\u0026response-content-disposition=attachment%3B+filename%3DTHE_FORMATION_OF_GLYCEROL_MONODECANOATE.pdf\u0026Expires=1734500944\u0026Signature=fVTquzk8KKGEe-GaPTf9aNr0qbb6~xPBlxTPUMcrZCEMAakha8fPX3X5PhSvwPTUWmuroJ7ylLNDQR0UU3sowyRNqU~-3DrxlV-QBSorQhSBuaVSOnfptYRaBk8e5EIv6WMb34dihaaBWLlPymERwzXaY6vRQoYinkMkMyHcyfa3plOF27AhpouBIyKEUDmDVJJ2~bFtu-Zv~wzB~b~LxD195dd3s7GI7tEX2DPeSJrJc~v6nSX8tFvqH8kADEg93VGBgwsqksAfovxUW7rWvTlnScJdmabVZXHGR~pib9TDXan~h971gTONpRk7MrgzYCXo-I8XXZyUM7EK-wnnUw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":522,"name":"Thermodynamics","url":"https://www.academia.edu/Documents/in/Thermodynamics"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":2215,"name":"Water","url":"https://www.academia.edu/Documents/in/Water"},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":5001,"name":"Astrobiology","url":"https://www.academia.edu/Documents/in/Astrobiology"},{"id":14920,"name":"Chemical Evolution","url":"https://www.academia.edu/Documents/in/Chemical_Evolution"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature"},{"id":161099,"name":"Biogenesis","url":"https://www.academia.edu/Documents/in/Biogenesis"},{"id":283379,"name":"Glycerol","url":"https://www.academia.edu/Documents/in/Glycerol"},{"id":346274,"name":"Dehydration","url":"https://www.academia.edu/Documents/in/Dehydration"},{"id":539878,"name":"Chemical Reaction","url":"https://www.academia.edu/Documents/in/Chemical_Reaction"},{"id":564340,"name":"Surface Active Agents","url":"https://www.academia.edu/Documents/in/Surface_Active_Agents"},{"id":888739,"name":"Quntitative Thin Layer Chromatography","url":"https://www.academia.edu/Documents/in/Quntitative_Thin_Layer_Chromatography"},{"id":969355,"name":"Abiogenesis","url":"https://www.academia.edu/Documents/in/Abiogenesis"}],"urls":[{"id":36750901,"url":"http://ci.nii.ac.jp/naid/110004066525"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110971493"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110971493/The_potential_and_challenges_of_nanopore_sequencing"><img alt="Research paper thumbnail of The potential and challenges of nanopore sequencing" class="work-thumbnail" src="https://attachments.academia-assets.com/108622933/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110971493/The_potential_and_challenges_of_nanopore_sequencing">The potential and challenges of nanopore sequencing</a></div><div class="wp-workCard_item"><span>Carolina Digital Repository (University of North Carolina at Chapel Hill)</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A nanopore-based device provides single-molecule detection and analytical capabilities that are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility. Further research and development to overcome current challenges to nanopore identification of each successive nucleotide in a DNA strand offers the prospect of `third generation' instruments that will sequence a diploid mammalian genome for ~$1,000 in ~24 h.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16ee2e6d993e4f9c4764f7c1124ef9d4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108622933,"asset_id":110971493,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108622933/download_file?st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&st=MTczNDQ5NzM0NCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110971493"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110971493"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110971493; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110971493]").text(description); $(".js-view-count[data-work-id=110971493]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110971493; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110971493']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110971493, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16ee2e6d993e4f9c4764f7c1124ef9d4" } } $('.js-work-strip[data-work-id=110971493]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110971493,"title":"The potential and challenges of nanopore sequencing","translated_title":"","metadata":{"publisher":"University of North Carolina at Chapel Hill","grobid_abstract":"A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. 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Schmidt, W. Vercoutere, D. Deamer, A.R. Hawkins, R. C. Quinn, A. S. Burton, and C. P. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">waters, H. Schmidt, W. Vercoutere, D. Deamer, A.R. Hawkins, R. C. Quinn, A. S. Burton, and C. P. 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