The shikimate pathway and its branches in apicomplexan parasites

<!DOCTYPE html> <html lang="en" > <head itemscope itemtype="http://schema.org/WebPage" prefix="og: http://ogp.me/ns#" > <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge">  <meta name="HandheldFriendly" content="True"> <meta name="MobileOptimized" content="320"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="preconnect" href="https://cdn.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.google-analytics.com"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.5ecf62baa0fa.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.452c70ce66f7.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.7bf600913d6e.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.0bfa59184c7a.css" type="text/css"> <title>The shikimate pathway and its branches in apicomplexan parasites - PubMed</title> <link rel="preload" as="font" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/uswds/dist/fonts/merriweather-bold-webfont.woff2" type="font/woff2" crossorigin />  <link rel="shortcut icon" type="image/ico" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.ico" /> <link rel="icon" type="image/png" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.png" />  <link rel="icon" type="image/png" sizes="192x192" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-192.png" />  <link rel="apple-touch-icon-precomposed" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-57.png">  <link rel="apple-touch-icon-precomposed" sizes="72x72" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-72.png">  <link rel="apple-touch-icon-precomposed" sizes="114x114" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-114.png">  <link rel="apple-touch-icon-precomposed" sizes="144x144" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-144.png">  <meta name="ncbi_sg_optimize_id" content="">  <meta name="theme-color" content="#20558a">  <meta name="referrer" content="origin-when-cross-origin"> <meta name="ncbi_pinger_gtm_track" content="true"/>  <meta name="ncbi_app" content="pubmed" /> <meta name="ncbi_db" content="pubmed" /> <meta name="ncbi_phid" content="79F0000142671E95000033414677BD04.1.m_6" /> <meta name="ncbi_pinger_stat_url" content="https://www.ncbi.nlm.nih.gov/stat" /> <meta name="log_category" content="literature" /> <meta name="ncbi_cost_center" content="pubmed" />  <meta name="ncbi_pdid" content="abstract" /> <meta name="log_op" content="retrieve" /> <meta name="uid" content="11865437" /> <meta name="ncbi_uid" content="11865437" /> <meta name="log_displayeduids" content="11865437" /> <meta name="log_source_db" content="pubmed" /> <meta name="log_icons_present" content="true" />  <meta name="description" content="The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for othe …"><meta name="keywords" content="pmid:11865437, doi:10.1086/338004, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review, Craig W Roberts, Fiona Roberts, Rima McLeod, Amino Acid Sequence, Animals, Apicomplexa / growth & development, Apicomplexa / metabolism*, Gene Expression Regulation, Glycine / analogs & derivatives*, Glycine / pharmacology, Glyphosate, Molecular Sequence Data, Phosphorus-Oxygen Lyases / chemistry, Phosphorus-Oxygen Lyases / genetics, Phosphorus-Oxygen Lyases / metabolism, Shikimic Acid / antagonists & inhibitors, Shikimic Acid / metabolism*, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="The shikimate pathway and its branches in apicomplexan parasites - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/11865437/"><meta property="og:description" content="The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for othe …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="The shikimate pathway and its branches in apicomplexan parasites - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/11865437/"><meta name="twitter:description" content="The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for othe …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/no-script.css"> </noscript> <meta name="citation_title" content="The shikimate pathway and its branches in apicomplexan parasites"> <meta name="citation_authors" content="Roberts CW;Roberts F;Lyons RE;Kirisits MJ;Mui EJ;Finnerty J;Johnson JJ;Ferguson DJ;Coggins JR;Krell T;Coombs GH;Milhous WK;Kyle DE;Tzipori S;Barnwell J;Dame JB;Carlton J;McLeod R;"> <meta name="citation_date" content="02/15/2002"> <meta name="citation_publisher" content="J Infect Dis"> <meta name="citation_journal_title" content="The Journal of infectious diseases"> <meta name="citation_pmid" content="11865437"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/11865437/"> <meta name="citation_volume" content="185 Suppl 1"> <meta name="citation_doi" content="10.1086/338004"> <meta name="citation_issn" content="0022-1899"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/11865437/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="mmnBredyN2CQFk5xLVsnY9rCDGmJWAMpsOvU03m7FHSmzwVkZiurUKiDpxQDE4pN"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="mmnBredyN2CQFk5xLVsnY9rCDGmJWAMpsOvU03m7FHSmzwVkZiurUKiDpxQDE4pN"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="mmnBredyN2CQFk5xLVsnY9rCDGmJWAMpsOvU03m7FHSmzwVkZiurUKiDpxQDE4pN"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="mmnBredyN2CQFk5xLVsnY9rCDGmJWAMpsOvU03m7FHSmzwVkZiurUKiDpxQDE4pN"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="11865437"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="mmnBredyN2CQFk5xLVsnY9rCDGmJWAMpsOvU03m7FHSmzwVkZiurUKiDpxQDE4pN"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 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<header class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="publication-type" >Review</div> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="The Journal of infectious diseases" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal The Journal of infectious diseases" data-pinger-ignore> J Infect Dis </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal The Journal of infectious diseases"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22J+Infect+Dis%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22J+Infect+Dis%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=J Infect Dis" data-ga-category="search" data-ga-action="journal_link" data-ga-label="J Infect Dis"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Infect+Dis%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="J Infect Dis"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Infect Dis"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Infect Dis"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2002 Feb 15:185 Suppl 1:S25-36.</span> </div> <span class="citation-doi"> doi: 10.1086/338004. </span> </div> <h1 class="heading-title"> The shikimate pathway and its branches in apicomplexan parasites </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Roberts+CW&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Craig W Roberts">Craig W Roberts</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, University of Strathclyde, Glasgow, United Kingdom." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Roberts+F&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Fiona Roberts">Fiona Roberts</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lyons+RE&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Russell E Lyons">Russell E Lyons</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kirisits+MJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael J Kirisits">Michael J Kirisits</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mui+EJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ernest J Mui">Ernest J Mui</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finnerty+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John Finnerty">John Finnerty</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Johnson+JJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jennifer J Johnson">Jennifer J Johnson</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ferguson+DJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David J P Ferguson">David J P Ferguson</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coggins+JR&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John R Coggins">John R Coggins</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Krell+T&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tino Krell">Tino Krell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coombs+GH&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Graham H Coombs">Graham H Coombs</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Milhous+WK&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wilbur K Milhous">Wilbur K Milhous</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kyle+DE&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dennis E Kyle">Dennis E Kyle</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tzipori+S&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Saul Tzipori">Saul Tzipori</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Barnwell+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John Barnwell">John Barnwell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dame+JB&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John B Dame">John B Dame</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Carlton+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jane Carlton">Jane Carlton</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McLeod+R&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rima McLeod">Rima McLeod</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/11865437/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Immunology, University of Strathclyde, Glasgow, United Kingdom.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">11865437</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1086/338004&id_type=DOI" href="https://doi.org/10.1086/338004" data-ga-category="full_text" data-ga-action="DOI" > 10.1086/338004 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Review</div> <h1 class="heading-title"> The shikimate pathway and its branches in apicomplexan parasites </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Craig W Roberts</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> J Infect Dis<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2002">2002</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/11865437/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" 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data-ga-label="J Infect Dis"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"J Infect Dis"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"J Infect Dis"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2002 Feb 15:185 Suppl 1:S25-36.</span> </div> <span class="citation-doi"> doi: 10.1086/338004. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Roberts+CW&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Craig W Roberts">Craig W Roberts</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, University of Strathclyde, Glasgow, United Kingdom." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Roberts+F&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Fiona Roberts">Fiona Roberts</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lyons+RE&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Russell E Lyons">Russell E Lyons</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kirisits+MJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael J Kirisits">Michael J Kirisits</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mui+EJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ernest J Mui">Ernest J Mui</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Finnerty+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John Finnerty">John Finnerty</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Johnson+JJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jennifer J Johnson">Jennifer J Johnson</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ferguson+DJ&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David J P Ferguson">David J P Ferguson</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coggins+JR&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John R Coggins">John R Coggins</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Krell+T&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Tino Krell">Tino Krell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Coombs+GH&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Graham H Coombs">Graham H Coombs</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Milhous+WK&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wilbur K Milhous">Wilbur K Milhous</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kyle+DE&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Dennis E Kyle">Dennis E Kyle</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tzipori+S&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Saul Tzipori">Saul Tzipori</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Barnwell+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John Barnwell">John Barnwell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dame+JB&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John B Dame">John B Dame</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Carlton+J&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jane Carlton">Jane Carlton</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McLeod+R&cauthor_id=11865437" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rima McLeod">Rima McLeod</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Immunology, University of Strathclyde, Glasgow, United Kingdom.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">11865437</strong> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1086/338004&id_type=DOI" href="https://doi.org/10.1086/338004" data-ga-category="full_text" data-ga-action="DOI" > 10.1086/338004 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/11865437/citations/" data-citation-style="nlm" data-pubmed-format-link="/11865437/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> The shikimate pathway is essential for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Seven enzymes of the shikimate pathway catalyze sequential conversion of erythrose 4-phosphate and phosphoenol pyruvate to chorismate. Chorismate is then used as a substrate for other pathways that culminate in production of folates, ubiquinone, napthoquinones, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. The shikimate pathway is absent from animals and present in the apicomplexan parasites Toxoplasma gondii, Plasmodium falciparum, and Cryptosporidium parvum. Inhibition of the pathway by glyphosate is effective in controlling growth of these parasites. These findings emphasize the potential benefits of developing additional effective inhibitors of the shikimate pathway. 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class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Shikimic+Acid%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Shikimic+Acid%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Shikimic Acid/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Shikimic Acid / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Shikimic+Acid" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Shikimic Acid / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Shikimic Acid/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Shikimic Acid/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Shikimic Acid" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Shikimic Acid </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Shikimic Acid"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Shikimic+Acid%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Shikimic+Acid%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Shikimic Acid"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Shikimic Acid"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Shikimic+Acid%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Shikimic Acid"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Shikimic Acid"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Shikimic Acid"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword chorismate synthase" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> chorismate synthase </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword chorismate synthase"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22chorismate+synthase%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22chorismate+synthase%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="chorismate synthase"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="chorismate synthase"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22chorismate+synthase%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="chorismate synthase"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""chorismate synthase"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""chorismate synthase"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Phosphorus-Oxygen Lyases" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Phosphorus-Oxygen Lyases </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Phosphorus-Oxygen Lyases"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Phosphorus-Oxygen+Lyases%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Phosphorus-Oxygen+Lyases%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Phosphorus-Oxygen Lyases"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Phosphorus-Oxygen Lyases"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Phosphorus-Oxygen+Lyases%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Phosphorus-Oxygen Lyases"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Phosphorus-Oxygen Lyases"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Phosphorus-Oxygen Lyases"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger 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The shikimate pathway and its branches in apicomplexan parasites - PubMed