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"https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F99445887%2FProtein_Carbohydrate_Interactions_Studied_by_NMR_From_Molecular_Recognition_to_Drug_Design%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F99445887%2FProtein_Carbohydrate_Interactions_Studied_by_NMR_From_Molecular_Recognition_to_Drug_Design%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":100533453,"identifier":"Attachment_100533453","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":99445887,"created_at":"2023-04-01T03:33:00.988-07:00","from_world_paper_id":230765431,"updated_at":"2024-11-26T06:22:52.386-08:00","_data":{"publisher":"Bentham Science Publishers Ltd.","grobid_abstract":"Diseases that result from infection are, in general, a consequence of specific interactions between a pathogenic organism and the cells. The study of host-pathogen interactions has provided insights for the design of drugs with therapeutic properties. One area that has proved to be promising for such studies is the constituted by carbohydrates which participate in biological processes of paramount importance. On the one hand, carbohydrates have shown to be information carriers with similar, if not higher, importance than traditionally considered carriers as amino acids and nucleic acids. On the other hand, the knowledge on molecular recognition of sugars by lectins and other carbohydrate-binding proteins has been employed for the development of new biomedical strategies. Biophysical techniques such as X-Ray crystallography and NMR spectroscopy lead currently the investigation on this field. In this review, a description of traditional and novel NMR methodologies employed in the study of sugar-protein interactions is briefly presented in combination with a palette of NMR-based studies related to biologically and/or pharmaceutically relevant applications.","publication_date":"2012,,","publication_name":"Current Protein and Peptide Science","grobid_abstract_attachment_id":"100533453"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Protein-Carbohydrate Interactions Studied by NMR: From Molecular Recognition to Drug Design","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32697169]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":100533453,"attachmentType":"pdf"}"><img alt="First page of “Protein-Carbohydrate Interactions Studied by NMR: From Molecular Recognition to Drug Design”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/100533453/mini_magick20230401-1-92w2nu.png?1680345317" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Protein-Carbohydrate Interactions Studied by NMR: From Molecular Recognition to Drug Design</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="32697169" href="https://independent.academia.edu/FilipaMarcelo"><img alt="Profile image of Filipa Marcelo" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Filipa Marcelo</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2012, Current Protein and Peptide Science</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">15 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 99445887; 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data-entity-id="103575248" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103575248/NMR_and_Modeling_Studies_of_Protein_Carbohydrate_Interactions_Synthesis_Three_Dimensional_Structure_and_Recognition_Properties_of_a_Minimum_Hevein_Domain_with_Binding_Affinity_for_Chitooligosaccharides">NMR and Modeling Studies of Protein-Carbohydrate Interactions: Synthesis, Three-Dimensional Structure, and Recognition Properties of a Minimum Hevein Domain with Binding Affinity for Chitooligosaccharides</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="231883651" href="https://independent.academia.edu/FranciscoJavierCA%C3%91ADA">Francisco Javier CAÑADA</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ChemBioChem, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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href="https://www.academia.edu/103575248/NMR_and_Modeling_Studies_of_Protein_Carbohydrate_Interactions_Synthesis_Three_Dimensional_Structure_and_Recognition_Properties_of_a_Minimum_Hevein_Domain_with_Binding_Affinity_for_Chitooligosaccharides"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="10337128" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/10337128/NMR_investigations_of_protein_carbohydrate_interactions_insights_into_the_topology_of_the_bound_conformation_of_a_lactose_isomer_and_%CE%B2_galactosyl_xyloses_to_mistletoe_lectin_and_galectin_1">NMR investigations of protein–carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and β-galactosyl xyloses to mistletoe lectin and galectin-1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="25348542" href="https://upr.academia.edu/LuisIturrino">Luis Iturrino</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimica Et Biophysica Acta-general Subjects, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NMR investigations of protein–carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and β-galactosyl xyloses to mistletoe lectin and galectin-1","attachmentId":47432169,"attachmentType":"pdf","work_url":"https://www.academia.edu/10337128/NMR_investigations_of_protein_carbohydrate_interactions_insights_into_the_topology_of_the_bound_conformation_of_a_lactose_isomer_and_%CE%B2_galactosyl_xyloses_to_mistletoe_lectin_and_galectin_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/10337128/NMR_investigations_of_protein_carbohydrate_interactions_insights_into_the_topology_of_the_bound_conformation_of_a_lactose_isomer_and_%CE%B2_galactosyl_xyloses_to_mistletoe_lectin_and_galectin_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="118565709" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/118565709/NMR_and_Molecular_Recognition_of_N_Glycans_Remote_Modifications_of_the_Saccharide_Chain_Modulate_Binding_Features">NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27345245" href="https://csic.academia.edu/FJavierCa%C3%B1ada">F Javier Cañada</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ACS chemical biology, 2017</p><p class="ds-related-work--abstract ds2-5-body-sm">Glycans play a key role as recognition elements in the communication of cells and other organisms. Thus, the analysis of carbohydrate-protein interactions has gained significant importance. In particular, nuclear magnetic resonance (NMR) techniques are considered powerful tools to detect relevant features in the interaction between sugars and their natural receptors. Here, we present the results obtained in the study on the molecular recognition of different mannose-containing glycans by Pisum sativum agglutinin. NMR experiments supported by Corcema-ST analysis, isothermal titration calorimetry (ITC) experiments, and molecular dynamics (MD) protocols have been successfully applied to unmask important binding features and especially to determine how a remote branching substituent significantly alters the binding mode of the sugar entity. These results highlight the key influence of common structural modifications in natural glycans on molecular recognition processes and underscore th...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features","attachmentId":114160531,"attachmentType":"pdf","work_url":"https://www.academia.edu/118565709/NMR_and_Molecular_Recognition_of_N_Glycans_Remote_Modifications_of_the_Saccharide_Chain_Modulate_Binding_Features","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/118565709/NMR_and_Molecular_Recognition_of_N_Glycans_Remote_Modifications_of_the_Saccharide_Chain_Modulate_Binding_Features"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="32006242" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32006242/Structure_elucidation_of_glycoprotein_glycans_and_of_polysaccharides_by_NMR_spectroscopy">Structure elucidation of glycoprotein glycans and of polysaccharides by NMR spectroscopy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35623300" href="https://independent.academia.edu/JohannesVliegenthart">Johannes Vliegenthart</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biotechnology, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Structure elucidation of glycoprotein glycans and of polysaccharides by NMR spectroscopy","attachmentId":52273678,"attachmentType":"pdf","work_url":"https://www.academia.edu/32006242/Structure_elucidation_of_glycoprotein_glycans_and_of_polysaccharides_by_NMR_spectroscopy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/32006242/Structure_elucidation_of_glycoprotein_glycans_and_of_polysaccharides_by_NMR_spectroscopy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":100533453,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":100533453,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_100533453" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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href="https://www.academia.edu/25825208/A_Structural_Study_by_19F_Nuclear_Magnetic_Resonance_of_the_Binding_of_Sugars_to_Lysozyme">A Structural Study by 19F-Nuclear-Magnetic Resonance of the Binding of Sugars to Lysozyme</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49554664" href="https://independent.academia.edu/RaymondDwek">Raymond Dwek</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Biochemistry, 1972</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Structural Study by 19F-Nuclear-Magnetic Resonance of the Binding of Sugars to 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Screening","attachmentId":52791590,"attachmentType":"pdf","work_url":"https://www.academia.edu/32619411/Fluorinated_Carbohydrates_as_Lectin_Ligands_Biorelevant_Sensors_with_Capacity_to_Monitor_Anomer_Affinity_in_19F_NMR_Based_Inhibitor_Screening","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/32619411/Fluorinated_Carbohydrates_as_Lectin_Ligands_Biorelevant_Sensors_with_Capacity_to_Monitor_Anomer_Affinity_in_19F_NMR_Based_Inhibitor_Screening"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="57006572" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/57006572/NMR_Molecular_Modeling_and_Crystallographic_Studies_of_Lentil_Lectin_Sucrose_Interaction">NMR, Molecular Modeling, and Crystallographic Studies of Lentil Lectin-Sucrose Interaction</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32382429" href="https://independent.academia.edu/LWyns">L. Wyns</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"NMR, Molecular Modeling, and Crystallographic Studies of Lentil Lectin-Sucrose Interaction","attachmentId":72113871,"attachmentType":"pdf","work_url":"https://www.academia.edu/57006572/NMR_Molecular_Modeling_and_Crystallographic_Studies_of_Lentil_Lectin_Sucrose_Interaction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/57006572/NMR_Molecular_Modeling_and_Crystallographic_Studies_of_Lentil_Lectin_Sucrose_Interaction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="124510499" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/124510499/A_1H_NMR_database_computer_program_for_the_analysis_of_the_primary_structure_of_complex_carbohydrates">A 1H NMR database computer program for the analysis of the primary structure of complex carbohydrates</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35623300" href="https://independent.academia.edu/JohannesVliegenthart">Johannes Vliegenthart</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Carbohydrate Research, 1992</p><div 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Kiessling</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35349839" href="https://independent.academia.edu/DekWoolfson">Dek Woolfson</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31125986" href="https://ubc.academia.edu/KieranHudson">Kieran L Hudson</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Carbohydrate−Aromatic Interactions in Proteins","attachmentId":53136132,"attachmentType":"pdf","work_url":"https://www.academia.edu/33025594/Carbohydrate_Aromatic_Interactions_in_Proteins","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/33025594/Carbohydrate_Aromatic_Interactions_in_Proteins"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="107307094" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107307094/Molecular_Recognition_of_Carbohydrates_Using_a_Synthetic_Receptor_A_Model_System_to_Understand_the_Stereoselectivity_of_a_Carbohydrate_Carbohydrate_Interaction_in_Water">Molecular Recognition of Carbohydrates Using a Synthetic Receptor. A Model System to Understand the Stereoselectivity of a Carbohydrate-Carbohydrate Interaction in Water</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="221445527" href="https://independent.academia.edu/vicentcristina">cristina vicent</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of the American Chemical Society, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular Recognition of Carbohydrates Using a Synthetic Receptor. 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