CINXE.COM

<!DOCTYPE html><html lang="en"><head><link rel="preload" as="image" imageSrcSet="https://thebmj-frontend.bmj.com/_next/image?url=https%3A%2F%2Fthebmj-frontend.bmj.com%2Fnext-resources%2Fthebmj-logo-large.png&w=110&q=75 1x, https://thebmj-frontend.bmj.com/_next/image?url=https%3A%2F%2Fthebmj-frontend.bmj.com%2Fnext-resources%2Fthebmj-logo-large.png&w=220&q=75 2x"/><meta charSet="utf-8"/><meta name="viewport" content="minimum-scale=1, initial-scale=1, width=device-width, shrink-to-fit=no, viewport-fit=cover"/><link rel="shortcut icon" href="https://thebmj-frontend.bmj.com/next-resources/favicon.ico" type="image/vnd.microsoft.icon"/><title>The BMJ State of the Art Reviews</title><meta name="title" content="The BMJ State of the Art Reviews"/><meta name="twitter:title" content="The BMJ State of the Art Reviews"/><meta property="og:title" content="The BMJ State of the Art Reviews"/><meta name="description" content="In-depth analysis of the most up to date knowledge of a clinical topic. Offers students, postdocs and clinical specialists a great overview, and may help researchers identify what remains unknown or unclear and worthy of researching next."/><meta name="twitter:description" content="In-depth analysis of the most up to date knowledge of a clinical topic. Offers students, postdocs and clinical specialists a great overview, and may help researchers identify what remains unknown or unclear and worthy of researching next."/><meta property="og:description" content="In-depth analysis of the most up to date knowledge of a clinical topic. Offers students, postdocs and clinical specialists a great overview, and may help researchers identify what remains unknown or unclear and worthy of researching next."/><meta name="twitter:image" content="https://www.bmj.com/next-resources/the-bmj-logo.png"/><meta property="og:image" content="https://www.bmj.com/next-resources/the-bmj-logo.png"/><meta name="twitter:card" content="summary_large_image"/><meta property="og:url" content="https://www.bmj.com/education/clinical-review"/><meta name="next-head-count" content="15"/><link rel="preload" href="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" as="script" data-domain-script="565e50dd-f6e9-46d6-91cd-5c40a270264f"/><script async="" src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" data-domain-script="565e50dd-f6e9-46d6-91cd-5c40a270264f"></script><link rel="preload" href="https://thebmj-frontend.bmj.com/next-resources/oneTrust.js" as="script"/><script async="" src="https://thebmj-frontend.bmj.com/next-resources/oneTrust.js" type="text/javascript"></script><link rel="preload" href="https://securepubads.g.doubleclick.net/tag/js/gpt.js" as="script"/><script async="" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script><link rel="preconnect dns-prefetch" href="https://analytics.bmj.com"/><link rel="preconnect dns-prefetch" href="https://adservice.google.com"/><link rel="preconnect dns-prefetch" href="https://www.google-analytics.com"/><link rel="preconnect dns-prefetch" href="https://securepubads.g.doubleclick.net"/><link rel="preconnect dns-prefetch" href="https://cdn-eu.pagesense.io"/><link rel="preconnect dns-prefetch" href="https://popup.wisepops.com"/><link rel="preconnect dns-prefetch" href="https://www.medtargetsystem.com"/><link rel="preconnect dns-prefetch" href="https://secure.polldaddy.com"/><link rel="preconnect dns-prefetch" href="https://cdn.pbgrd.com/core-bmj.js?t=1653636702"/><script async="" type="text/javascript" src="https://cdn.pbgrd.com/core-bmj.js?t=1653636702"></script><script async=""> var topBottomSizes = [ { label: "xs", breakpoint: "20em", sizes: [ [300, 50], [320, 100], ], }, { label: "sm", breakpoint: "30em", sizes: [[468, 60]] }, { label: "lg", breakpoint: "46em", sizes: [[728, 90]] }, { label: "xl", breakpoint: "61em", sizes: [[970, 90]] }, { label: "xxl", breakpoint: "80em", sizes: [[970, 250]] }, ].reduce(function (e, t) { var a = [].concat(e) return ( window.matchMedia("screen and (min-width: " + t.breakpoint + ")") .matches && (a = a.concat(t.sizes)), a ) }, []), mpu1Size = [300, 600], mpu2Size = [300, 250], googletag = googletag || {}; googletag.cmd = googletag.cmd || []; googletag.cmd.push(function () { googletag .defineSlot( "/21798771943/BMJ.com_HomePage_TOPBanner", topBottomSizes, "div-gpt-ad-7326006-1" ) .addService(googletag.pubads()) .setTargeting("pgid", "pubgrade_lib_disabled"); googletag .defineSlot( "/21798771943/BMJ.com_HomePage_MPU1", mpu1Size, "div-gpt-ad-7326006-2" ) .addService(googletag.pubads()); googletag .defineSlot( "/21798771943/BMJ.com_HomePage_MPU2", mpu2Size, "div-gpt-ad-7326006-3" ) .addService(googletag.pubads()); googletag.pubads().setTargeting("url", window.parent.location.pathname); googletag.pubads().enableSingleRequest(); googletag.enableServices(); }) </script><script async=""> function parseCookies() { let cookieHeader = document.cookie || ""; let cookies = Object.fromEntries( cookieHeader.split("; ").map((c) => c.split("=")) ); for (let key in cookies) { if (cookies[key] === "undefined") { cookies[key] = undefined; } } return cookies; } function uuidv4() { var d = new Date().getTime(); //Timestamp var d2 = (typeof performance !== "undefined" && performance.now && performance.now() * 1000) || 0; //Time in microseconds since page-load or 0 if unsupported return "xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx".replace(/[xy]/g, function (c) { var r = Math.random() * 16; //random number between 0 and 16 if (d > 0) { //Use timestamp until depleted r = (d + r) % 16 | 0; d = Math.floor(d / 16); } else { //Use microseconds since page-load if supported r = (d2 + r) % 16 | 0; d2 = Math.floor(d2 / 16); } return (c === "x" ? r : (r & 0x3) | 0x8).toString(16); }); } function handleCookie() { let cookies = parseCookies(); let bmj_uuid = cookies.bmj_uuid; if (!bmj_uuid) { bmj_uuid = uuidv4(); cookies.bmj_uuid = bmj_uuid; } return { bmj_uuid }; } let { bmj_uuid } = handleCookie(); let bmj_ppid = parseCookies().bmj_ppid; window.dataLayer = window.dataLayer || []; function checkUserLoginStatus(dataLayer) { const userMail = dataLayer.find((item) => item.user)?.user?.mail; if (!userMail) { return false; } return userMail !== anonMailId; } const anonMailId = "e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855"; let nonAnonMailId = dataLayer.find((item) => item.user)?.user?.mail === anonMailId ? null : dataLayer.find((item) => item.user)?.user?.mail; let userId = dataLayer.find((item) => item.user)?.user?.["data-ics"] ?? (dataLayer.find((item) => item.user)?.user?.mail && nonAnonMailId) ?? bmj_ppid ?? bmj_uuid; googletag.cmd.push(function () { googletag.pubads().setPublisherProvidedId(userId); googletag.pubads().setTargeting("islogged", checkUserLoginStatus(dataLayer) ? "true" : "false"); googletag.enableServices(); }); document.cookie = "bmj_ppid=" + userId + "; domain=.bmj.com; path=/; max-age=31622400; SameSite=None; Secure"; document.cookie = "bmj_uuid=" + bmj_uuid + "; domain=.bmj.com; path=/; max-age=31622400; SameSite=None; Secure"; window.dataLayer.push({ bmj_uuid: bmj_uuid, }); </script><script async="">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://analytics.bmj.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-NF7HCLL');</script><link rel="preload" href="/_next/static/css/0125e1088e5e73c9.css" as="style"/><link rel="stylesheet" href="/_next/static/css/0125e1088e5e73c9.css" data-n-g=""/><noscript data-n-css=""></noscript><script defer="" nomodule="" src="/_next/static/chunks/polyfills-c67a75d1b6f99dc8.js"></script><script src="/_next/static/chunks/webpack-6ef43a8d4a395f49.js" defer=""></script><script src="/_next/static/chunks/framework-3b5a00d5d7e8d93b.js" defer=""></script><script src="/_next/static/chunks/main-fc788ce92ccfeb2d.js" defer=""></script><script src="/_next/static/chunks/pages/_app-68563fa3593348f3.js" defer=""></script><script src="/_next/static/chunks/100-933a18c4a3ce9023.js" defer=""></script><script src="/_next/static/chunks/363-c279d1e5e0049870.js" defer=""></script><script src="/_next/static/chunks/pages/%5Bslug%5D/%5BarticleType%5D-bc03eeb8e17154d1.js" defer=""></script><script src="/_next/static/8jC_R7aE1p2nLhz3DYNM7/_buildManifest.js" defer=""></script><script src="/_next/static/8jC_R7aE1p2nLhz3DYNM7/_ssgManifest.js" defer=""></script></head><body><noscript><iframe src="https://analytics.bmj.com/ns.html?id=GTM-NF7HCLL" height="0" width="0" style="display:none;visibility:hidden;"></iframe></noscript><div id="__next"><div><div class="undefined flex justify-center items-center min-w-[auto] min-h-[100px] md:min-h-[250px]"><div id="div-gpt-ad-7326006-1" data-testid="top-ad-slot" class="flex justify-center items-center w-[auto] h-[100px] md:h-[250px]"></div></div><div data-testid="page-with-menu" class="transition-transform duration-300 ease-in-out"><div class="text-center">Intended for healthcare professionals</div><section class="hidden sm:flex bg-bmj-grey-30"><section class="max-w-[80rem] px-sm mx-auto w-full"><div data-testid="user-bar" class="flex justify-end items-center"><a data-testid="our-company" href="https://www.bmj.com/company" class="text-bmj-blue-600 no-underline p-[0.25rem] mr-4 text-base hover:text-font-color-link-hover hover:underline">Our Company</a><a data-testid="subscribe" href="https://www.bmj.com/uk/subscribe" class="text-bmj-blue-600 no-underline p-[0.25rem] mr-4 text-base hover:text-font-color-link-hover hover:underline">Subscribe</a><a data-testid="my-account" href="https://myaccount.bmj.com/myaccount/account/hw-registration.html" class="text-bmj-blue-600 no-underline p-[0.25rem] mr-4 text-base hover:text-font-color-link-hover hover:underline">My Account</a><a data-testid="login" href="https://www.bmj.com/user/login" class="text-bmj-blue-600 no-underline p-[0.25rem] mr-4 text-base hover:text-font-color-link-hover hover:underline">Login</a></div></section></section><nav class="bg-bmj-blue-500 relative z-20 w-full" data-headlessui-state=""><div data-testid="menu-bar" class="mx-auto sm2:px-4 lg2:px-6 px-[0.4rem] lg2:pr-0"><div class="relative flex h-16"><button class="lg2:hidden inline-flex items-center justify-center rounded-md p-2 sm2:p-0 text-white hover:bg-bmj-blue-500 focus:outline-none focus:ring-2 focus:ring-gray-200 dark:text-white dark:focus:ring-transparent max-w-[80rem] mx-auto"><span class="sr-only">Open main menu</span><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" fill="currentColor" aria-hidden="true" class="block h-6 w-6"><path fill-rule="evenodd" d="M2 4.75A.75.75 0 012.75 4h14.5a.75.75 0 010 1.5H2.75A.75.75 0 012 4.75zM2 10a.75.75 0 01.75-.75h14.5a.75.75 0 010 1.5H2.75A.75.75 0 012 10zm0 5.25a.75.75 0 01.75-.75h14.5a.75.75 0 010 1.5H2.75a.75.75 0 01-.75-.75z" clip-rule="evenodd"></path></svg></button><div class="flex w-full items-center max-w-[80rem] mx-auto"><a href="/" class="flex items-center"><div class="leading-0 ml-[0.20rem] mr-[0.5rem]" data-testid="logo"><img alt="The BMJ Logo" layout="fixed" srcSet="https://thebmj-frontend.bmj.com/_next/image?url=https%3A%2F%2Fthebmj-frontend.bmj.com%2Fnext-resources%2Fthebmj-logo-large.png&w=110&q=75 1x, https://thebmj-frontend.bmj.com/_next/image?url=https%3A%2F%2Fthebmj-frontend.bmj.com%2Fnext-resources%2Fthebmj-logo-large.png&w=220&q=75 2x" src="https://thebmj-frontend.bmj.com/_next/image?url=https%3A%2F%2Fthebmj-frontend.bmj.com%2Fnext-resources%2Fthebmj-logo-large.png&w=220&q=75" width="110" height="40" decoding="async" data-nimg="1" class="min-w-full w-[6.87rem] mr-2 ml-[0.20rem]" loading="eager" style="color:transparent"/></div></a><div data-testid="desktop-menu" class="hidden sm2:hidden md2:flex md2:justify-between md2:w-full lg2:flex lg2:justify-start lg2:w-auto"><div class="flex w-full justify-between flex-shrink-0"><section class="flex"><a data-testid="covid-19" href="/coronavirus" class="block px-2 py-4 md2:py-[1.10rem] text-lg text-white hover:bg-bmj-blue-400">covid-19</a><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="research" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:Rj5kn6:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Research <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="education" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:Rl5kn6:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Education <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="news-views" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:Rn5kn6:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">News & Views <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="campaigns" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:Rp5kn6:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Campaigns <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="jobs" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:Rr5kn6:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Jobs <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div></section><section class="lg2:flex flex-row md2:hidden md2:ml-[5rem]"><a data-testid="archive" href="/archive" class="flex lg2:px-2 md2:px-0 py-4 md2:py-[1.10rem] text-lg text-white hover:bg-bmj-blue-400">Archive</a><a data-testid="for-authors" href="/about-bmj/resources-authors" class="flex lg2:px-2 md2:px-0 py-4 md2:py-[1.10rem] text-lg text-white hover:bg-bmj-blue-400">For authors</a><a data-testid="hosted" href="http://hosted.bmj.com" class="flex lg2:px-2 md2:px-0 py-4 md2:py-[1.10rem] text-lg text-white hover:bg-bmj-blue-400">Hosted</a></section></div><div class="hidden md2:block lg2:block absolute lg2:static right-[6px]"><a class="text-white flex items-center p-4 lg2:py-5 md2:py-[20px] text-lg leading-5 hover:bg-bmj-blue-400 hover:text-white group" href="/search/advanced" data-testid="search" aria-label="Search"><svg aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" width="24" height="24" class="text-[1.5rem] pr-[0.3rem] text-bmj-blue-300 group-hover:text-white"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><span class="hidden lg2:inline">Search</span></a></div></div></div></div></div><div data-testid="mobile-menu" class="-translate-x-full fixed top-0 left-0 w-[16rem] h-screen bg-bmj-blue-500 z-10 transform transition-transform duration-300 ease-in-out overflow-y-auto sm2:mt-[3.5rem] md2:mt-[3.5rem] lg2:mt-0 mt-[1.5rem]"><div class="md2:hidden text-left"><a href="/coronavirus" class="text-lg px-4 block text-white hover:bg-bmj-blue-400 border-b border-white border-opacity-30 py-[18px]">covid-19</a><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="research" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:R16b76:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Research <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="education" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:R1ab76:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Education <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="news-views" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:R1eb76:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">News & Views <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="campaigns" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:R1ib76:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Campaigns <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div><div data-testid="sub-menus" class="sm2:relative sm2:z-1" data-headlessui-state=""><button data-testid="jobs" class="flex w-full items-center px-4 py-[18px] text-lg text-white text-left hover:bg-bmj-blue-400 md2:py-[1.10rem] md2:px-[0.4rem] border-b border-white border-opacity-30 lg2:border-0 md2:border-0" id="headlessui-menu-button-:R1mb76:" type="button" aria-haspopup="menu" aria-expanded="false" data-headlessui-state="">Jobs <svg class="ml-[0.10rem] h-4 w-3" fill="currentColor" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><path fill-rule="evenodd" d="M5.293 7.293a1 1 0 011.414 0L10 10.586l3.293-3.293a1 1 0 111.414 1.414l-4 4a1 1 0 01-1.414 0l-4-4a1 1 0 010-1.414z" clip-rule="evenodd"></path></svg></button></div></div><section class="flex flex-col text-lg"><a data-testid="archive" href="/archive" class="block px-4 py-[18px] text-left text-l text-white hover:bg-bmj-blue-400 border-b border-white border-opacity-30">Archive</a><a data-testid="for-authors" href="/about-bmj/resources-authors" class="block px-4 py-[18px] text-left text-l text-white hover:bg-bmj-blue-400 border-b border-white border-opacity-30">For authors</a><a data-testid="hosted" href="http://hosted.bmj.com" class="block px-4 py-[18px] text-left text-l text-white hover:bg-bmj-blue-400 border-b border-white border-opacity-30">Hosted</a></section></div><div class="md2:hidden absolute right-[8px] bottom-[5px]"><a class="text-white flex items-center p-4 lg2:py-5 md2:py-[20px] text-lg leading-5 hover:bg-bmj-blue-400 hover:text-white group" href="/search/advanced" data-testid="search" aria-label="Search"><svg aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" width="24" height="24" class="text-[1.5rem] pr-[0.3rem] text-bmj-blue-300 group-hover:text-white"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><span class="hidden lg2:inline">Search</span></a></div></nav><div class=""><div><div class="w-full max-w-[80rem] mx-auto pt-sm md:pt-lg pb-xl px-sm"><div data-testid="breadcrumbs"><span class="text-font-color-medium leading-4 text-xs"><a class="no-underline text-font-color-link hover:underline" href="/">Home</a><span class="mx-xsm">/</span></span><span class="text-font-color-medium leading-4 text-xs"><a class="no-underline text-font-color-link hover:underline" href="/education">Education</a><span class="mx-xsm">/</span></span><span class="text-[0.75rem] leading-[1rem] text-font-color-medium">State of the art review</span></div><h1 class="font-normal text-[1.625rem] md:text-[2.125rem] leading-[2.25rem] md:leading-[2.5rem] text-font-color-extra-dark mt-sm md:mt-md">State of the art review</h1><section class="mt-xsm md:mt-sm"><span class="text-bmj-grey-700" data-testid="channel-page-summary">Showing results 1-100</span><div data-testid="channel-page-order" class="hidden md:inline-block ml-[2rem]"><span class="text-bmj-grey-700">Sorted by:</span><span class="ml-xsm text-bmj-grey-700">Most recent</span></div></section><div data-testid="article-list-separator" class="mt-lg mb-xsm border-t undefined border-solid"></div><div class="flex"><div class="w-1/2 pr-2"><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/387/bmj-2024-081860"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of psoriatic arthritis in adults</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 21, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/387/bmj-2023-076612"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Acute respiratory distress syndrome</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 28, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/387/bmj-2024-079343"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">The impact of increasing temperatures due to climate change on infectious diseases</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 4, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/386/bmj-2023-076246"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of atrial fibrillation in older adults</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 17, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/386/bmj-2023-077318"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Device associated complications in the intensive care unit</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 13, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/386/bmj-2023-077205"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Evaluation and management of hypertensive emergency</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 26, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/386/bmj-2022-073823"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">New and emerging treatments for major depressive disorder</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 8, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/385/bmj-2023-079108"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of resistant hypertension</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 19, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/385/bmj-2023-074962"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of cancer of the esophagus</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 3, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/385/bmj-2023-075859"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Cardiovascular toxicity of immune therapies for cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 15, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/385/bmj-2023-074892"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Deprescribing in older adults with polypharmacy</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 7, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/385/bmj-2023-077025"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in management of heart failure</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 10, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/384/bmj-2022-072686"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Effectiveness and safety of drugs for obesity</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 25, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/384/bmj-2023-070920"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of chronic pancreatitis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 26, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/384/bmj-2023-076743"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Treatment of bladder cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 12, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/384/bmj-2023-075681"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">New advances in type 1 diabetes</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 26, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/384/bmj-2022-070856"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Therapeutic advances in rheumatoid arthritis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 17, 2024</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2022-071027"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Long term outcomes of metabolic/bariatric surgery in adults</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 18, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2022-073995"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of pancreatic cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 13, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2022-074216"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of chronic kidney disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 5, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2023-077090"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the understanding and management of alcohol-related liver disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 20, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2023-075037"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 27, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/383/bmj-2022-073980"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of systemic lupus erythematosus</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 26, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/382/bmj-2022-071565"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the care of breast cancer survivors</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 18, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/382/bmj-2022-074630"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of epilepsy during pregnancy and lactation</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 8, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/382/bmj-2022-073923"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Pathophysiology, diagnosis, and management of neuroinflammation in covid-19</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 18, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/382/bmj-2022-072612"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of perimenopausal and menopausal symptoms</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 8, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/382/bmj-2022-071675"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 4, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/381/bmj-2022-071653"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Hypertensive disorders of pregnancy</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 30, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/381/bmj-2022-072715"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Venous thromboembolism in patients with cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 1, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/381/bmj-2022-071674"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in systemic therapies for triple negative breast cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 30, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/381/bmj-2022-070630"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Suicide in young people: screening, risk assessment, and intervention</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 24, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/381/bmj-2022-073591"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of bipolar disorders</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 12, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/380/bmj-2022-071726"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Cognitive impairment after cancer treatment</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 15, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/380/bmj-2021-069717"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 27, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/380/bmj-2022-070201"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of autoimmune hepatitis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 6, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/380/bmj-2022-072398"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Telemental health for clinical assessment and treatment</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 16, 2023</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/379/bmj-2022-070115"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Human papillomavirus vaccination and cervical cancer risk</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 15, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/379/bmj-2022-070499"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in diagnosis and treatment of testicular cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 28, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/379/bmj-2022-070750"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Pathophysiology, diagnosis, and management of endometriosis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 14, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/379/bmj-2021-068718"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of psychiatric and cognitive complications in Parkinson’s disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 24, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/379/bmj-2021-067670"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of chronic migraine</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 10, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/378/bmj-2021-068956"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Chimeric antigen receptor T cell therapy for cancer: clinical applications</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 31, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/378/bmj-2021-069741"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Covid-19 vaccination in pregnancy</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 10, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/378/bmj-2021-065997"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Impact of vaping on respiratory health</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 18, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/377/bmj-2021-066354"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of idiopathic pulmonary fibrosis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 29, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/377/bmj-2021-067085"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Revascularisation in stable coronary artery disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 13, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/377/bmj-2020-059818"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Clinical decision support in cardiovascular medicine</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 25, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="https://www.bmj.com/content/377/bmj-2021-069739"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of covid-19 in pregnancy</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 26, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="https://www.bmj.com/content/377/bmj-2020-063439"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Novel treatments in B cell non-Hodgkin’s lymphomas</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 21, 2022</span></div></div></section></div><div class="w-1/2 pl-2"><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/377/bmj-2021-060154"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Prognostication and shared decision making in neurocritical care</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 7, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/376/bmj-2020-059577"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of cluster headache</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 16, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/376/bmj-2021-057212"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">New generation psychological treatments in chronic pain</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 28, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/376/bmj-2020-063161"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the management of cardioembolic stroke associated with patent foramen ovale</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 9, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/376/bmj.o64"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of functional neurological disorder</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 24, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/376/bmj-2021-064389"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnostic reasoning in cardiovascular medicine</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 5, 2022</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="content/375/bmj-2021-065871"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of pneumonia in critically ill patients</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 6, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/375/bmj-2021-065871"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of pneumonia in critically ill patients</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 6, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/375/bmj-2021-060602"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of ischaemia with non-obstructive coronary arteries (INOCA)</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 26, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/375/bmj.n2363"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in systemic therapy for non-small cell lung cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 9, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/375/bmj.n1974"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Diagnosis and management of bronchopulmonary dysplasia</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 20, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/375/bmj.n2026"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in acute myeloid leukemia</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 6, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/374/bmj.n1855"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Screening and prevention of colorectal cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 15, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/374/bmj.n1593"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Cardiovascular care of older adults</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 31, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/374/bmj.n1493"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Medication adherence in cardiovascular medicine</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 11, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/374/bmj.n1648"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Long covid—mechanisms, risk factors, and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 26, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/374/bmj.n1380"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Glucocorticoid induced adrenal insufficiency</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 12, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/373/bmj.n955"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Regenerative medicine for neurological diseases</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 23, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/373/bmj.n1007"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Delirium and long term cognition in critically ill patients</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 8, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/373/bmj.n784"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Treatment of opioid use disorder in primary care</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 19, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/373/bmj.n776"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Role of coronary artery calcium score in the primary prevention of cardiovascular disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 4, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/373/bmj.n379"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Screening and management of atrial fibrillation in primary care</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 12, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.n72"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of colonic diverticulitis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 24, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.n436"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Severe covid-19 pneumonia: pathogenesis and clinical management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 10, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.n188"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Vaccines for older adults</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 22, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.m4979"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Uveitis for the non-ophthalmologist</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 3, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.m4747"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of non-alcoholic fatty liver disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 18, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/372/bmj.m4447"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Axial spondyloarthritis: new advances in diagnosis and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 4, 2021</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/371/bmj.m4050"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Cancer of unknown primary</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 7, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/371/bmj.m3786"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the diagnosis and management of gastroesophageal reflux disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 23, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/371/bmj.m3773"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Treatment of epithelial ovarian cancer</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">November 9, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/371/bmj.m3544"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">New advances in the diagnosis and management of hepatocellular carcinoma</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 26, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/371/bmj.m3109"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of hypertriglyceridemia</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">October 12, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m3176"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Emerging immunotherapies in multiple myeloma</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 21, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m2687"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Hepatorenal syndrome: pathophysiology, diagnosis, and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 14, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m2200"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Hepatitis B virus persistence and reactivation</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">September 1, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m2177"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Pulmonary embolism: update on management and controversies</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">August 5, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m1668"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 20, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/370/bmj.m1624"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Prenatal regenerative fetoscopic interventions for congenital anomalies</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">July 1, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/369/bmj.m1067"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in the diagnosis and management of IgG4 related disease</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">June 16, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/369/bmj.m1041"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Lyme borreliosis: diagnosis and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">May 26, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/369/bmj.m718"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Advances in regenerative medicine for otolaryngology/head and neck surgery</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 29, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/369/bmj.m736"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Autoimmune complications of immunotherapy: pathophysiology and management</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">April 6, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/368/bmj.m421"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of ANCA associated vasculitis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 18, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/368/bmj.m216"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Current and future treatments for tuberculosis</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">March 2, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/368/bmj.l6983"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Management of acute ischemic stroke</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">February 13, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/368/bmj.l6880"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 28, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/368/bmj.l6670"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">January 7, 2020</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/367/bmj.l6459"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Does general anesthesia affect neurodevelopment in infants and children?</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 9, 2019</span></div></div></section><section class="py-2 md:py-3 flex flex-col justify-between" data-testid="article-entry-large"><a class="text-font-color-dark hover:text-font-color-medium" data-testid="article-entry-link" href="/content/367/bmj.l6217"><h2 data-testid="article-entry-title" color="font-color-dark" class="titleHover">Cognitive symptoms of Alzheimer’s disease: clinical management and prevention</h2></a><div><div class="flex text-xs leading-4 mb-2 text-bmj-grey-600 pt-2"><span data-testid="article-entry-date" class="whitespace-nowrap">December 6, 2019</span></div></div></section></div></div><div data-testid="article-list-separator" class="mt-md md:mt-sm border-t undefined border-solid"></div><span class="mt-sm text-bmj-grey-700">Can’t find what you’re looking for?</span><a class="text-font-color-link block mt-1 hover:underline hover:text-font-color-link-hover" href="/search/advanced/toc_section%3Aclinical%20review%20numresults%3A50%20sort%3Apublication-date%20direction%3Adescending%20format_result%3Astandard?page=1">Continue to all clinical review articles</a></div></div><div data-testid="page-footer" class="footer bg-bmj-blue-500"><div class="max-w-[80rem] px-sm mx-auto"><div class="grid-cols-cols-1-1 md:grid-cols-cols-1-1-1-1 bg-bmj-blue-500 text-white grid gap-x-3 gap-y-1 grid-mobile grid-tablet grid-desktop"><div data-testid="follow-us-on" style="grid-area:follow-us-on"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">Follow us on</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 flex flex-row flex-wrap sm:flex-col [&>li]:mr-8 sm:[&>li]:mr-0"><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://twitter.com/bmj_latest" alt="Twitter" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><svg aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" width="21" height="24" data-testid="media-link" class="text-2xl mr-[0.66rem] mb-[4.8px]"><path fill="currentColor" d="M400 32H48C21.5 32 0 53.5 0 80v352c0 26.5 21.5 48 48 48h352c26.5 0 48-21.5 48-48V80c0-26.5-21.5-48-48-48zm-48.9 158.8c.2 2.8.2 5.7.2 8.5 0 86.7-66 186.6-186.6 186.6-37.2 0-71.7-10.8-100.7-29.4 5.3.6 10.4.8 15.8.8 30.7 0 58.9-10.4 81.4-28-28.8-.6-53-19.5-61.3-45.5 10.1 1.5 19.2 1.5 29.6-1.2-30-6.1-52.5-32.5-52.5-64.4v-.8c8.7 4.9 18.9 7.9 29.6 8.3a65.447 65.447 0 01-29.2-54.6c0-12.2 3.2-23.4 8.9-33.1 32.3 39.8 80.8 65.8 135.2 68.6-9.3-44.5 24-80.6 64-80.6 18.9 0 35.9 7.9 47.9 20.7 14.8-2.8 29-8.3 41.6-15.8-4.9 15.2-15.2 28-28.8 36.1 13.2-1.4 26-5.1 37.8-10.2-8.9 13.1-20.1 24.7-32.9 34z"></path></svg><span class="hover:underline">Twitter</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.facebook.com/bmjdotcom" alt="Facebook" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><svg aria-hidden="true" data-testid="media-link" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" width="21" height="24" class="text-2xl mr-[0.66rem] mb-[4.8px]"><path fill="currentColor" d="M400 32H48A48 48 0 000 80v352a48 48 0 0048 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0048-48V80a48 48 0 00-48-48z"></path></svg><span class="hover:underline">Facebook</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://youtube.com/user/BMJmedia" alt="YouTube" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><svg aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" width="21" height="24" data-testid="media-link" class="text-2xl mr-[0.66rem] mb-[4.8px]"><path fill="currentColor" d="M186.8 202.1l95.2 54.1-95.2 54.1V202.1zM448 80v352c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V80c0-26.5 21.5-48 48-48h352c26.5 0 48 21.5 48 48zm-42 176.3s0-59.6-7.6-88.2c-4.2-15.8-16.5-28.2-32.2-32.4C337.9 128 224 128 224 128s-113.9 0-142.2 7.7c-15.7 4.2-28 16.6-32.2 32.4-7.6 28.5-7.6 88.2-7.6 88.2s0 59.6 7.6 88.2c4.2 15.8 16.5 27.7 32.2 31.9C110.1 384 224 384 224 384s113.9 0 142.2-7.7c15.7-4.2 28-16.1 32.2-31.9 7.6-28.5 7.6-88.1 7.6-88.1z"></path></svg><span class="hover:underline">YouTube</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://feeds.bmj.com/bmj/recent" alt="RSS" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><svg aria-hidden="true" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512" width="21" height="24" data-testid="media-link" class="text-2xl mr-[0.66rem] mb-[4.8px]"><path fill="currentColor" d="M400 32H48C21.49 32 0 53.49 0 80v352c0 26.51 21.49 48 48 48h352c26.51 0 48-21.49 48-48V80c0-26.51-21.49-48-48-48zM112 416c-26.51 0-48-21.49-48-48s21.49-48 48-48 48 21.49 48 48-21.49 48-48 48zm157.533 0h-34.335c-6.011 0-11.051-4.636-11.442-10.634-5.214-80.05-69.243-143.92-149.123-149.123-5.997-.39-10.633-5.431-10.633-11.441v-34.335c0-6.535 5.468-11.777 11.994-11.425 110.546 5.974 198.997 94.536 204.964 204.964.352 6.526-4.89 11.994-11.425 11.994zm103.027 0h-34.334c-6.161 0-11.175-4.882-11.427-11.038-5.598-136.535-115.204-246.161-251.76-251.76C68.882 152.949 64 147.935 64 141.774V107.44c0-6.454 5.338-11.664 11.787-11.432 167.83 6.025 302.21 141.191 308.205 308.205.232 6.449-4.978 11.787-11.432 11.787z"></path></svg><span class="hover:underline">RSS</span></a></li></ul></div><div data-testid="content-links" style="grid-area:content-links"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">Content links</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://www.bmj.com/collections" alt="Collections" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Collections</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://www.bmj.com/health-in-south-asia" alt="Health in South Asia" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Health in South Asia</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://www.bmj.com/content/women%E2%80%99s-children%E2%80%99s-and-adolescents%E2%80%99-health-0" alt="Women’s, children’s & adolescents’ health" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Women’s, children’s & adolescents’ health</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://www.bmj.com/freezikaresources" alt="Zika virus" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Zika virus</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/research" alt="Research" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Research</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/education" alt="Education" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Education</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/news" alt="News and views" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">News and views</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://blogs.bmj.com/bmj/" alt="BMJ Opinion" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Opinion</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/rapid-responses" alt="Rapid responses" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Rapid responses</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/archive" alt="Archive" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Archive</span></a></li></ul></div><div data-testid="about-us" style="grid-area:about-us"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">About us</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj" alt="About us" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">About us</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/editorial-staff" alt="Editorial staff" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Editorial staff</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/editorial-staff/bmj-united-states" alt="BMJ in the USA" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ in the USA</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/health-in-latin-america" alt="BMJ in Latin America" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ in Latin America</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/editorial-staff/bmj-south-asia" alt="BMJ in South Asia" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ in South Asia</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/advisory-panels" alt="Advisers" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Advisers</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-authors/forms-policies-and-checklists" alt="Policies" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Policies</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://mc.manuscriptcentral.com/bmj" alt="Submit your paper" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Submit your paper</span></a></li></ul></div><div data-testid="resources" style="grid-area:resources"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">Resources</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-authors" alt="Authors" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Authors</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-reviewers" alt="Reviewers" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Reviewers</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-bma-members" alt="BMA members" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMA members</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-readers" alt="Readers" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Readers</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-subscribers" alt="Subscribers" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Subscribers</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-advertisers-and-sponsors" alt="Advertisers and sponsors" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Advertisers and sponsors</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/resources-media" alt="Media" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Media</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://recruiter.bmj.com/" alt="Recruiters" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Recruiters</span></a></li></ul></div><div data-testid="explore-bmj" style="grid-area:explore-bmj"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">Explore BMJ</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/company/?int_source=tbmj&int_medium=footer&int_campaign=URLswitch" alt="Our company" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Our company</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://jobs.bmj.com/" alt="BMJ Careers" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Careers</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://learning.bmj.com/" alt="BMJ Learning" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Learning</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://masterclasses.bmj.com/" alt="BMJ Masterclasses" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Masterclasses</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://journals.bmj.com/" alt="BMJ Journals" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Journals</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/student" alt="BMJ Student" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Student</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://www.bmj.com/about-bmj/resources-readers" alt="Academic edition of The BMJ" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Academic edition of The BMJ</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://bestpractice.bmj.com/" alt="BMJ Best Practice" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">BMJ Best Practice</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://thebmjawards.bmj.com/home" alt="The BMJ Awards" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">The BMJ Awards</span></a></li></ul></div><div data-testid="my-account" style="grid-area:my-account"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">My account</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://myaccount.bmj.com/myaccount/account/hw-registration.html" alt="Email alerts" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Email alerts</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="http://journals.bmj.com/cgi/activate" alt="Activate subscription" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Activate subscription</span></a></li></ul></div><div data-testid="information" style="grid-area:information"><h2 class="text-[1.25rem] text-white font-extralight pt-4 leading-[1.25rem] pb-[1rem]">Information</h2><ul class="display-[grid] grid-cols-3 grid-rows-2 grid-gap-x-4 grid-gap-y-4 p-0 "><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/contact-us" alt="Contact us" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Contact us</span></a></li><li data-testid="icon-link" class="list-none flex mobile-list"><a href="https://www.bmj.com/about-bmj/complaints-procedure" alt="Complaints" class="text-white no-underline py-[1rem] sm:py-0 text-[0.875rem] font-normal flex hover:underline"><span class="hover:underline">Complaints</span></a></li></ul></div><div data-testid="quick-links" style="grid-area:quick-links" class="text-center"><a href="#!" id="ot-sdk-btn" class="ot-sdk-show-settings !leading-[1.5rem] !text-white bg-bmj-blue-500 hover:underline hover:!bg-bmj-blue-500 !text-[0.875rem] !border-r-[1px] !border-solid !border-white !border-0 !px-[0.31rem] !py-0 !inline-flex" alt="Cookie settings">Cookie settings</a><a data-testid="quick-links" href="https://www.bmj.com/company/your-privacy/cookies-policy/" alt="Cookie Policy" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">Cookie Policy</span></a><a data-testid="quick-links" href="https://www.bmj.com/company/your-privacy/" alt="Privacy policy" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">Privacy policy</span></a><a data-testid="quick-links" href="http://www.bmj.com/company/legal-information/" alt="Website T&Cs" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">Website T&Cs</span></a><a data-testid="quick-links" href="http://group.bmj.com/group/about/revenue-sources" alt="Revenue Sources" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">Revenue Sources</span></a><a data-testid="quick-links" href="http://home.highwire.org/" alt="HighWire Press" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">HighWire Press</span></a><a data-testid="quick-links" href="https://www.bmj.com/sitemap" alt="Sitemap" class="text-font-color-white no-underline py-2 sm:py-2 lg:py-0 text-[0.875rem] font-normal inline-flex"><span class="hover:underline px-[0.31rem] border-r-[1px] border-solid border-white">Sitemap</span></a></div><div data-testid="copyright" class="text-center" style="grid-area:copyright"><span>Copyright © 2024 BMJ Publishing Group Ltd</span></div></div></div></div></div></div></div></div><script type="text/javascript">if (window.NodeList && !NodeList.prototype.forEach) { NodeList.prototype.forEach = Array.prototype.forEach }</script><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"totalPages":"2","results":[{"title":"Advances in the management of psoriatic arthritis in adults","url":"/content/387/bmj-2024-081860","date":"November 21, 2024"},{"title":"Acute respiratory distress syndrome","url":"/content/387/bmj-2023-076612","date":"October 28, 2024"},{"title":"The impact of increasing temperatures due to climate change on infectious diseases","url":"/content/387/bmj-2024-079343","date":"October 4, 2024"},{"title":"Management of atrial fibrillation in older adults","url":"/content/386/bmj-2023-076246","date":"September 17, 2024"},{"title":"Device associated complications in the intensive care unit","url":"/content/386/bmj-2023-077318","date":"August 13, 2024"},{"title":"Evaluation and management of hypertensive emergency","url":"/content/386/bmj-2023-077205","date":"July 26, 2024"},{"title":"New and emerging treatments for major depressive disorder","url":"/content/386/bmj-2022-073823","date":"July 8, 2024"},{"title":"Diagnosis and management of resistant hypertension","url":"/content/385/bmj-2023-079108","date":"June 19, 2024"},{"title":"Diagnosis and management of cancer of the esophagus","url":"/content/385/bmj-2023-074962","date":"June 3, 2024"},{"title":"Cardiovascular toxicity of immune therapies for cancer","url":"/content/385/bmj-2023-075859","date":"May 15, 2024"},{"title":"Deprescribing in older adults with polypharmacy","url":"/content/385/bmj-2023-074892","date":"May 7, 2024"},{"title":"Advances in management of heart failure","url":"/content/385/bmj-2023-077025","date":"April 10, 2024"},{"title":"Effectiveness and safety of drugs for obesity","url":"/content/384/bmj-2022-072686","date":"March 25, 2024"},{"title":"Management of chronic pancreatitis","url":"/content/384/bmj-2023-070920","date":"February 26, 2024"},{"title":"Treatment of bladder cancer","url":"/content/384/bmj-2023-076743","date":"February 12, 2024"},{"title":"New advances in type 1 diabetes","url":"/content/384/bmj-2023-075681","date":"January 26, 2024"},{"title":"Therapeutic advances in rheumatoid arthritis","url":"/content/384/bmj-2022-070856","date":"January 17, 2024"},{"title":"Long term outcomes of metabolic/bariatric surgery in adults","url":"/content/383/bmj-2022-071027","date":"December 18, 2023"},{"title":"Advances in the management of pancreatic cancer","url":"/content/383/bmj-2022-073995","date":"December 13, 2023"},{"title":"Advances in the management of chronic kidney disease","url":"/content/383/bmj-2022-074216","date":"December 5, 2023"},{"title":"Advances in the understanding and management of alcohol-related liver disease","url":"/content/383/bmj-2023-077090","date":"November 20, 2023"},{"title":"Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis","url":"/content/383/bmj-2023-075037","date":"October 27, 2023"},{"title":"Advances in the management of systemic lupus erythematosus","url":"/content/383/bmj-2022-073980","date":"October 26, 2023"},{"title":"Advances in the care of breast cancer survivors","url":"/content/382/bmj-2022-071565","date":"September 18, 2023"},{"title":"Management of epilepsy during pregnancy and lactation","url":"/content/382/bmj-2022-074630","date":"September 8, 2023"},{"title":"Pathophysiology, diagnosis, and management of neuroinflammation in covid-19","url":"/content/382/bmj-2022-073923","date":"August 18, 2023"},{"title":"Management of perimenopausal and menopausal symptoms","url":"/content/382/bmj-2022-072612","date":"August 8, 2023"},{"title":"Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome","url":"/content/382/bmj-2022-071675","date":"July 4, 2023"},{"title":"Hypertensive disorders of pregnancy","url":"/content/381/bmj-2022-071653","date":"June 30, 2023"},{"title":"Venous thromboembolism in patients with cancer","url":"/content/381/bmj-2022-072715","date":"June 1, 2023"},{"title":"Advances in systemic therapies for triple negative breast cancer","url":"/content/381/bmj-2022-071674","date":"May 30, 2023"},{"title":"Suicide in young people: screening, risk assessment, and intervention","url":"/content/381/bmj-2022-070630","date":"April 24, 2023"},{"title":"Diagnosis and management of bipolar disorders","url":"/content/381/bmj-2022-073591","date":"April 12, 2023"},{"title":"Cognitive impairment after cancer treatment","url":"/content/380/bmj-2022-071726","date":"March 15, 2023"},{"title":"Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management","url":"/content/380/bmj-2021-069717","date":"February 27, 2023"},{"title":"Diagnosis and management of autoimmune hepatitis","url":"/content/380/bmj-2022-070201","date":"February 6, 2023"},{"title":"Telemental health for clinical assessment and treatment","url":"/content/380/bmj-2022-072398","date":"January 16, 2023"},{"title":"Human papillomavirus vaccination and cervical cancer risk","url":"/content/379/bmj-2022-070115","date":"December 15, 2022"},{"title":"Advances in diagnosis and treatment of testicular cancer","url":"/content/379/bmj-2022-070499","date":"November 28, 2022"},{"title":"Pathophysiology, diagnosis, and management of endometriosis","url":"/content/379/bmj-2022-070750","date":"November 14, 2022"},{"title":"Management of psychiatric and cognitive complications in Parkinson’s disease","url":"/content/379/bmj-2021-068718","date":"October 24, 2022"},{"title":"Management of chronic migraine","url":"/content/379/bmj-2021-067670","date":"October 10, 2022"},{"title":"Chimeric antigen receptor T cell therapy for cancer: clinical applications","url":"/content/378/bmj-2021-068956","date":"August 31, 2022"},{"title":"Covid-19 vaccination in pregnancy","url":"/content/378/bmj-2021-069741","date":"August 10, 2022"},{"title":"Impact of vaping on respiratory health","url":"/content/378/bmj-2021-065997","date":"July 18, 2022"},{"title":"Advances in the management of idiopathic pulmonary fibrosis","url":"/content/377/bmj-2021-066354","date":"June 29, 2022"},{"title":"Revascularisation in stable coronary artery disease","url":"/content/377/bmj-2021-067085","date":"June 13, 2022"},{"title":"Clinical decision support in cardiovascular medicine","url":"/content/377/bmj-2020-059818","date":"May 25, 2022"},{"title":"Diagnosis and management of covid-19 in pregnancy","url":"https://www.bmj.com/content/377/bmj-2021-069739","date":"April 26, 2022"},{"title":"Novel treatments in B cell non-Hodgkin’s lymphomas","url":"https://www.bmj.com/content/377/bmj-2020-063439","date":"April 21, 2022"},{"title":"Prognostication and shared decision making in neurocritical care","url":"/content/377/bmj-2021-060154","date":"April 7, 2022"},{"title":"Diagnosis and management of cluster headache","url":"/content/376/bmj-2020-059577","date":"March 16, 2022"},{"title":"New generation psychological treatments in chronic pain","url":"/content/376/bmj-2021-057212","date":"February 28, 2022"},{"title":"Advances in the management of cardioembolic stroke associated with patent foramen ovale","url":"/content/376/bmj-2020-063161","date":"February 9, 2022"},{"title":"Diagnosis and management of functional neurological disorder","url":"/content/376/bmj.o64","date":"January 24, 2022"},{"title":"Diagnostic reasoning in cardiovascular medicine","url":"/content/376/bmj-2021-064389","date":"January 5, 2022"},{"title":"Management of pneumonia in critically ill patients","url":"content/375/bmj-2021-065871","date":"December 6, 2021"},{"title":"Management of pneumonia in critically ill patients","url":"/content/375/bmj-2021-065871","date":"December 6, 2021"},{"title":"Management of ischaemia with non-obstructive coronary arteries (INOCA)","url":"/content/375/bmj-2021-060602","date":"November 26, 2021"},{"title":"Advances in systemic therapy for non-small cell lung cancer","url":"/content/375/bmj.n2363","date":"November 9, 2021"},{"title":"Diagnosis and management of bronchopulmonary dysplasia","url":"/content/375/bmj.n1974","date":"October 20, 2021"},{"title":"Advances in acute myeloid leukemia","url":"/content/375/bmj.n2026","date":"October 6, 2021"},{"title":"Screening and prevention of colorectal cancer","url":"/content/374/bmj.n1855","date":"September 15, 2021"},{"title":"Cardiovascular care of older adults","url":"/content/374/bmj.n1593","date":"August 31, 2021"},{"title":"Medication adherence in cardiovascular medicine","url":"/content/374/bmj.n1493","date":"August 11, 2021"},{"title":"Long covid—mechanisms, risk factors, and management","url":"/content/374/bmj.n1648","date":"July 26, 2021"},{"title":"Glucocorticoid induced adrenal insufficiency","url":"/content/374/bmj.n1380","date":"July 12, 2021"},{"title":"Regenerative medicine for neurological diseases","url":"/content/373/bmj.n955","date":"June 23, 2021"},{"title":"Delirium and long term cognition in critically ill patients","url":"/content/373/bmj.n1007","date":"June 8, 2021"},{"title":"Treatment of opioid use disorder in primary care","url":"/content/373/bmj.n784","date":"May 19, 2021"},{"title":"Role of coronary artery calcium score in the primary prevention of cardiovascular disease","url":"/content/373/bmj.n776","date":"May 4, 2021"},{"title":"Screening and management of atrial fibrillation in primary care","url":"/content/373/bmj.n379","date":"April 12, 2021"},{"title":"Management of colonic diverticulitis","url":"/content/372/bmj.n72","date":"March 24, 2021"},{"title":"Severe covid-19 pneumonia: pathogenesis and clinical management","url":"/content/372/bmj.n436","date":"March 10, 2021"},{"title":"Vaccines for older adults","url":"/content/372/bmj.n188","date":"February 22, 2021"},{"title":"Uveitis for the non-ophthalmologist","url":"/content/372/bmj.m4979","date":"February 3, 2021"},{"title":"Management of non-alcoholic fatty liver disease","url":"/content/372/bmj.m4747","date":"January 18, 2021"},{"title":"Axial spondyloarthritis: new advances in diagnosis and management","url":"/content/372/bmj.m4447","date":"January 4, 2021"},{"title":"Cancer of unknown primary","url":"/content/371/bmj.m4050","date":"December 7, 2020"},{"title":"Advances in the diagnosis and management of gastroesophageal reflux disease","url":"/content/371/bmj.m3786","date":"November 23, 2020"},{"title":"Treatment of epithelial ovarian cancer","url":"/content/371/bmj.m3773","date":"November 9, 2020"},{"title":"New advances in the diagnosis and management of hepatocellular carcinoma","url":"/content/371/bmj.m3544","date":"October 26, 2020"},{"title":"Management of hypertriglyceridemia","url":"/content/371/bmj.m3109","date":"October 12, 2020"},{"title":"Emerging immunotherapies in multiple myeloma","url":"/content/370/bmj.m3176","date":"September 21, 2020"},{"title":"Hepatorenal syndrome: pathophysiology, diagnosis, and management","url":"/content/370/bmj.m2687","date":"September 14, 2020"},{"title":"Hepatitis B virus persistence and reactivation","url":"/content/370/bmj.m2200","date":"September 1, 2020"},{"title":"Pulmonary embolism: update on management and controversies","url":"/content/370/bmj.m2177","date":"August 5, 2020"},{"title":"Placebos in chronic pain: evidence, theory, ethics, and use in clinical practice","url":"/content/370/bmj.m1668","date":"July 20, 2020"},{"title":"Prenatal regenerative fetoscopic interventions for congenital anomalies","url":"/content/370/bmj.m1624","date":"July 1, 2020"},{"title":"Advances in the diagnosis and management of IgG4 related disease","url":"/content/369/bmj.m1067","date":"June 16, 2020"},{"title":"Lyme borreliosis: diagnosis and management","url":"/content/369/bmj.m1041","date":"May 26, 2020"},{"title":"Advances in regenerative medicine for otolaryngology/head and neck surgery","url":"/content/369/bmj.m718","date":"April 29, 2020"},{"title":"Autoimmune complications of immunotherapy: pathophysiology and management","url":"/content/369/bmj.m736","date":"April 6, 2020"},{"title":"Management of ANCA associated vasculitis","url":"/content/368/bmj.m421","date":"March 18, 2020"},{"title":"Current and future treatments for tuberculosis","url":"/content/368/bmj.m216","date":"March 2, 2020"},{"title":"Management of acute ischemic stroke","url":"/content/368/bmj.l6983","date":"February 13, 2020"},{"title":"Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?","url":"/content/368/bmj.l6880","date":"January 28, 2020"},{"title":"Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment","url":"/content/368/bmj.l6670","date":"January 7, 2020"},{"title":"Does general anesthesia affect neurodevelopment in infants and children?","url":"/content/367/bmj.l6459","date":"December 9, 2019"},{"title":"Cognitive symptoms of Alzheimer’s disease: clinical management and prevention","url":"/content/367/bmj.l6217","date":"December 6, 2019"}],"articleType":"State of the art review","headingText":"State of the art review","baseHeadingLevel":1,"breadcrumbs":[{"pageName":"Home","url":"/"},{"pageName":"Education","url":"/education"},{"pageName":"State of the art review"}],"moreUrl":"/search/advanced/toc_section%3Aclinical review%20numresults%3A50%20sort%3Apublication-date%20direction%3Adescending%20format_result%3Astandard?page=1","moreText":"Continue to all clinical review articles","metadata":{"title":"The BMJ State of the Art Reviews","description":"In-depth analysis of the most up to date knowledge of a clinical topic. Offers students, postdocs and clinical specialists a great overview, and may help researchers identify what remains unknown or unclear and worthy of researching next.","image":"https://www.bmj.com/next-resources/the-bmj-logo.png","currentPath":"/education/clinical-review"}},"__N_SSG":true},"page":"/[slug]/[articleType]","query":{"slug":"education","articleType":"clinical-review"},"buildId":"8jC_R7aE1p2nLhz3DYNM7","isFallback":false,"gsp":true,"scriptLoader":[]}</script></body></html>