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For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality. Epidemiological trends indicate recent and predicted increases in the burden of disease. Disease progression is driven by continued alcohol exposure on a background of genetic predisposition together with environmental cofactors. Most individuals present with advanced disease despite a long history of excessive alcohol consumption and multiple missed opportunities to intervene. Increasing evidence supports the use of non-invasive tests to screen for and identify disease at earlier stages. There is a definite role for public health measures to reduce the overall burden of disease. At an individual level, however, the ability to influence subsequent disease course by modifying alcohol consumption or the underlying pathogenic mechanisms remains limited due to a comparative lack of effective, disease-modifying medical interventions. Abstinence from alcohol is the key determinant of outcome in established ALD and the cornerstone of clinical management. In those with decompensated ALD, liver transplant has a clear role. There is consensus that abstinence from alcohol for an arbitrary period should not be the sole determinant in a decision to transplant. An increasing understanding of the mechanisms by which alcohol causes liver disease in susceptible individuals offers the prospect of new therapeutic targets for disease-modifying drugs. Successful translation will require significant public and private investment in a disease area which has traditionally been underfunded when compared to its overall prevalence." /> <meta name="DC.Contributor" content="Mark Thursz" /> <meta name="DC.Contributor" content="Anne Lingford-Hughes" /> <meta name="article:published_time" content="2023-11-20" /> <meta name="article:section" content="Clinical Review" /> <meta name="citation_title" content="Advances in the understanding and management of alcohol-related liver disease" /> <meta name="citation_abstract" lang="en" content="<h3>Abstract</h3> <p>Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality. Epidemiological trends indicate recent and predicted increases in the burden of disease. Disease progression is driven by continued alcohol exposure on a background of genetic predisposition together with environmental cofactors. Most individuals present with advanced disease despite a long history of excessive alcohol consumption and multiple missed opportunities to intervene. Increasing evidence supports the use of non-invasive tests to screen for and identify disease at earlier stages. There is a definite role for public health measures to reduce the overall burden of disease. At an individual level, however, the ability to influence subsequent disease course by modifying alcohol consumption or the underlying pathogenic mechanisms remains limited due to a comparative lack of effective, disease-modifying medical interventions. Abstinence from alcohol is the key determinant of outcome in established ALD and the cornerstone of clinical management. In those with decompensated ALD, liver transplant has a clear role. There is consensus that abstinence from alcohol for an arbitrary period should not be the sole determinant in a decision to transplant. An increasing understanding of the mechanisms by which alcohol causes liver disease in susceptible individuals offers the prospect of new therapeutic targets for disease-modifying drugs. Successful translation will require significant public and private investment in a disease area which has traditionally been underfunded when compared to its overall prevalence.</p>" /> <meta name="citation_journal_title" content="BMJ" /> <meta name="citation_publisher" content="British Medical Journal Publishing Group" /> <meta name="citation_publication_date" content="2023/11/20" /> <meta name="citation_mjid" content="bmj;383/nov20_5/e077090" /> <meta name="citation_id" content="383/nov20_5/e077090" /> <meta name="citation_public_url" content="https://www.bmj.com/content/383/bmj-2023-077090" /> <meta name="citation_abstract_html_url" content="https://www.bmj.com/content/383/bmj-2023-077090.abstract" /> <meta name="citation_full_html_url" content="https://www.bmj.com/content/383/bmj-2023-077090.full" /> <meta name="citation_pdf_url" content="https://www.bmj.com/content/bmj/383/bmj-2023-077090.full.pdf" /> <meta name="citation_issn" content="1756-1833" /> <meta name="citation_journal_abbrev" content="BMJ" /> <meta name="citation_doi" content="10.1136/bmj-2023-077090" /> <meta name="citation_pmid" content="37984967" /> <meta name="citation_volume" content="383" /> <meta name="citation_article_type" content="Review Article" /> <meta name="citation_section" content="Clinical Review" /> <meta name="citation_author" content="Mark Thursz" /> <meta name="citation_author_institution" content="Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK" /> <meta name="citation_author" content="Anne Lingford-Hughes" /> <meta name="citation_author_institution" content="Department of Brain Sciences, Imperial College London, London, UK" /> <meta name="citation_reference" content="citation_journal_title=Alimentary pharmacology & therapeutics;citation_journal_abbrev=Aliment Pharmacol Ther;citation_author=E. Nguyen-Khac;citation_author=D. Chatelain;citation_author=B. Tramier;citation_title=Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests.;citation_pages=1188-1198;citation_volume=28;citation_year=2008;citation_issue=10;citation_pmid=18705692;citation_doi=10.1111/j.1365-2036.2008.03831.x" /> <meta name="citation_reference" content="citation_journal_title=EBioMedicine;citation_author=R. Parker;citation_author=SJ. Kim;citation_author=GY. Im;citation_title=Obesity in acute alcoholic hepatitis increases morbidity and mortality;citation_pages=511-8;citation_volume=45;citation_year=2019;citation_pmid=31278069;citation_doi=10.1016/j.ebiom.2019.03.046" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_title=EASL Clinical Practice Guidelines: Management of alcohol-related liver disease;citation_pages=154-81;citation_volume=69;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1016/j.jhep.2018.03.018" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=DW. Crabb;citation_author=R. Bataller;citation_author=NP. Chalasani;citation_title=Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA Alcoholic Hepatitis Consortia;citation_pages=785-90;citation_volume=150;citation_year=2016;citation_pmid=http://www.n;citation_doi=10.1053/j.gastro.2016.02.042" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=DW. Crabb;citation_author=GY. Im;citation_author=G. Szabo;citation_author=JL. Mellinger;citation_author=MR. Lucey;citation_title=Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American Association for the Study of Liver Diseases;citation_pages=306-33;citation_volume=71;citation_year=2020;citation_pmid=31314133;citation_doi=10.1002/hep.30866" /> <meta name="citation_reference" content="citation_journal_title=Lancet;citation_title=Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016;citation_volume=392;citation_year=2018;citation_pmid=30146330;citation_doi=10.1016/S0140-6736(18)31310-2" /> <meta name="citation_reference" content="citation_journal_title=Lancet Psychiatry;citation_title=The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016;citation_pages=987-1012;citation_volume=5;citation_year=2018;citation_pmid=30392731;citation_doi=10.1016/S2215-0366(18)30337-7" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_title=The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017;citation_pages=245-66;citation_volume=5;citation_year=2020;citation_pmid=31981519;citation_doi=10.1016/S2468-1253(19)30349-8" /> <meta name="citation_reference" content="citation_journal_title=JAMA Intern Med;citation_author=BP. Lee;citation_author=E. Vittinghoff;citation_author=JL. Dodge;citation_author=G. Cullaro;citation_author=NA. Terrault;citation_title=National trends and long-term outcomes of liver transplant for alcohol-associated liver disease in the United States;citation_pages=340-8;citation_volume=179;citation_year=2019;citation_pmid=30667468;citation_doi=10.1001/jamainternmed.2018.6536" /> <meta name="citation_reference" content="citation_year=2011" /> <meta name="citation_reference" content="NHS Blood and Transplant. Annual report on liver transplantation 2021/2022. 2022 https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/27814/nhsbt-liver-transplant-report-2122-final.pdf." /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=N. Sheron;citation_title=Alcohol and liver disease in Europe--Simple measures have the potential to prevent tens of thousands of premature deaths;citation_pages=957-67;citation_volume=64;citation_year=2016;citation_pmid=http://www.n;citation_doi=10.1016/j.jhep.2015.11.006" /> <meta name="citation_reference" content="citation_journal_title=Lancet;citation_author=J. Manthey;citation_author=KD. Shield;citation_author=M. Rylett;citation_author=OSM. Hasan;citation_author=C. Probst;citation_author=J. Rehm;citation_title=Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study;citation_volume=393;citation_year=2019;citation_pmid=31076174;citation_doi=10.1016/S0140-6736(18)32744-2" /> <meta name="citation_reference" content="citation_journal_title=Lancet Public Health;citation_author=J. Julien;citation_author=T. Ayer;citation_author=ED. Bethea;citation_author=EB. Tapper;citation_author=J. Chhatwal;citation_title=Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019-40: a modelling study;citation_pages=316e-23;citation_volume=5;citation_year=2020;citation_pmid=32504584;citation_doi=10.1016/S2468-2667(20)30062-1" /> <meta name="citation_reference" content="citation_journal_title=J Clin Gastroenterol;citation_author=S. Damjanovska;citation_author=DB. Karb;citation_author=SM. Cohen;citation_title=Increasing prevalence and racial disparity of alcohol-related gastrointestinal and liver disease during the COVID-19 pandemic: a population-based national study;citation_pages=185-8;citation_volume=57;citation_year=2023;citation_pmid=34999643;citation_doi=10.1097/MCG.0000000000001665" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_author=JU. Kim;citation_author=A. Majid;citation_author=R. Judge;citation_title=Effect of COVID-19 lockdown on alcohol consumption in patients with pre-existing alcohol use disorder;citation_pages=886-7;citation_volume=5;citation_year=2020;citation_pmid=32763197;citation_doi=10.1016/S2468-1253(20)30251-X" /> <meta name="citation_reference" content="citation_journal_title=Drug Alcohol Rev;citation_author=C. Kilian;citation_author=A. O’Donnell;citation_author=N. Potapova;citation_title=Changes in alcohol use during the COVID-19 pandemic in Europe: A meta-analysis of observational studies;citation_pages=918-31;citation_volume=41;citation_year=2022;citation_pmid=35187739;citation_doi=10.1111/dar.13446" /> <meta name="citation_reference" content="National Institute for Health and Care Excellence. Alcohol-use disorders: prevention (public health guideline PH24). 2010. https://www.nice.org.uk/guidance/ph24." /> <meta name="citation_reference" content="World Health Organization. Tackling NCDs: 'best buys' and other recommended interventions for the prevention and control of noncommunicable diseases. 2017. https://apps.who.int/iris/handle/10665/259232." /> <meta name="citation_reference" content="Institute of Alcohol Studies. Alcohol information and education factsheet. 2014. https://www.ias.org.uk/uploads/pdf/Factsheets/Alcohol%20information%20and%20education%20factsheet%20March%202014.pdf." /> <meta name="citation_reference" content="World Health Organization. No place for cheap alcohol: the potential value of minimum pricing for protecting lives. 2022. https://www.who.int/europe/publications/i/item/9789289058094." /> <meta name="citation_reference" content="citation_journal_title=Lancet Public Health;citation_author=P. Anderson;citation_author=A. O’Donnell;citation_author=E. Kaner;citation_author=EJ. Llopis;citation_author=J. Manthey;citation_author=J. Rehm;citation_title=Impact of minimum unit pricing on alcohol purchases in Scotland and Wales: controlled interrupted time series analyses;citation_volume=6;citation_year=2021;citation_pmid=34058125;citation_doi=10.1016/S2468-2667(21)00052-9" /> <meta name="citation_reference" content="citation_journal_title=BMJ Open;citation_author=J. Rehm;citation_author=A. O’Donnell;citation_author=EFS. Kaner;citation_author=E. Jane LLopis;citation_author=J. Manthey;citation_author=P. Anderson;citation_title=Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis;citation_volume=12;citation_year=2022;citation_pmid=35851006;citation_doi=10.1136/bmjopen-2021-054161" /> <meta name="citation_reference" content="citation_journal_title=Public Health Research;citation_author=V. So;citation_author=AD. Millard;citation_author=SV. Katikireddi;citation_title=Intended and unintended consequences of the implementation of minimum unit pricing of alcohol in Scotland: a natural experiment;citation_year=2021;citation_pmid=34699154;citation_doi=10.3310/phr09110" /> <meta name="citation_reference" content="Holmes J. Evaluating the impact of Minimum Unit Pricing in Scotland on people who are drinking at harmful levels: Final report. Public Health Scotland, 2022. https://www.publichealthscotland.scot/media/13486/evaluating-the-impact-of-minimum-unit-pricing-in-scotland-on-people-who-are-drinking-at-harmful-levels-report.pdf." /> <meta name="citation_reference" content="citation_journal_title=Alcohol Alcohol;citation_author=S. Chaudhary;citation_author=W. MacKey;citation_author=K. Duncan;citation_author=EH. Forrest;citation_title=Changes in hospital discharges with alcohol-related liver disease in a gastroenterology and general medical unit following the introduction of minimum unit pricing of alcohol: the GRI Q4 Study;citation_pages=477-82;citation_volume=57;citation_year=2022;citation_pmid=34343256;citation_doi=10.1093/alcalc/agab051" /> <meta name="citation_reference" content="citation_journal_title=Addiction;citation_author=J. Zhao;citation_author=T. Stockwell;citation_title=The impacts of minimum alcohol pricing on alcohol attributable morbidity in regions of British Colombia, Canada with low, medium and high mean family income;citation_pages=1942-51;citation_volume=112;citation_year=2017;citation_pmid=28600882;citation_doi=10.1111/add.13902" /> <meta name="citation_reference" content="citation_journal_title=JHEP Rep;citation_author=B. Fairfield;citation_author=B. Schnabl;citation_title=Gut dysbiosis as a driver in alcohol-induced liver injury;citation_pages=100220;citation_volume=3;citation_year=2020;citation_pmid=33598648;citation_doi=10.1016/j.jhepr.2020.100220" /> <meta name="citation_reference" content="citation_journal_title=Gut;citation_author=M. Llopis;citation_author=AM. Cassard;citation_author=L. Wrzosek;citation_title=Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease;citation_volume=65;citation_year=2016;citation_pmid=26642859;citation_doi=10.1136/gutjnl-2015-310585" /> <meta name="citation_reference" content="citation_journal_title=Nature;citation_author=Y. Duan;citation_author=C. Llorente;citation_author=S. Lang;citation_title=Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease;citation_pages=505-11;citation_volume=575;citation_year=2019;citation_pmid=http://www.n;citation_doi=10.1038/s41586-019-1742-x" /> <meta name="citation_reference" content="citation_journal_title=Gut Microbes;citation_author=L. Maccioni;citation_author=B. Gao;citation_author=S. Leclercq;citation_title=Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans;citation_pages=1782157;citation_volume=12;citation_year=2020;citation_pmid=32588725;citation_doi=10.1080/19490976.2020.1782157" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=H. Tilg;citation_author=AR. Moschen;citation_author=G. Szabo;citation_title=Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis;citation_pages=955-65;citation_volume=64;citation_year=2016;citation_pmid=26773297;citation_doi=10.1002/hep.28456" /> <meta name="citation_reference" content="citation_journal_title=Physiological Reviews;citation_journal_abbrev=Physiol. Rev.;citation_author=CS. Lieber;citation_title=Cytochrome P-4502E1: its physiological and pathological role;citation_pages=517-544;citation_volume=77;citation_year=1997;citation_issue=2;citation_pmid=9114822;citation_doi=10.1152/physrev.1997.77.2.517" /> <meta name="citation_reference" content="citation_journal_title=The American Journal of Clinical Nutrition;citation_journal_abbrev=Am J Clin Nutr;citation_author=ML. Martínez-Chantar;citation_author=ER. García-Trevijano;citation_author=MU. Latasa;citation_title=Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury;citation_pages=1177S-1182S;citation_volume=76;citation_year=2002;citation_issue=5;citation_pmid=12418501;citation_doi=10.1093/ajcn/76.5.1177S" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=M. You;citation_author=GE. Arteel;citation_title=Effect of ethanol on lipid metabolism;citation_pages=237-48;citation_volume=70;citation_year=2019;citation_pmid=30658725;citation_doi=10.1016/j.jhep.2018.10.037" /> <meta name="citation_reference" content="citation_journal_title=J Biol Chem;citation_author=M. You;citation_author=M. Fischer;citation_author=MA. Deeg;citation_author=DW. Crabb;citation_title=Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP);citation_volume=277;citation_year=2002;citation_pmid=12036955;citation_doi=10.1074/jbc.M202411200" /> <meta name="citation_reference" content="citation_journal_title=Journal of Investigative Medicine;citation_journal_abbrev=J Investig Med;citation_author=S. Liangpunsakul;citation_author=RA. Ross;citation_author=DW. Crabb;citation_title=Activation of Carbohydrate Response Element-Binding Protein by Ethanol;citation_pages=270-277;citation_volume=61;citation_year=2013;citation_issue=2;citation_pmid=23266705;citation_doi=10.2310/JIM.0b013e31827c2795" /> <meta name="citation_reference" content="citation_journal_title=Clinical Medicine;citation_journal_abbrev=Clin Med;citation_author=E. Scott;citation_author=QM. Anstee;citation_title=Genetics of alcoholic liver disease and non-alcoholic steatohepatitis;citation_pages=s54-s59;citation_volume=18;citation_year=2018;citation_issue=Suppl_2;citation_pmid=29700094;citation_doi=10.7861/clinmedicine.18-2-s54" /> <meta name="citation_reference" content="citation_journal_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_author=MR. Lucey;citation_author=P. Mathurin;citation_author=TR. Morgan;citation_title=Alcoholic hepatitis.;citation_pages=2758-2769;citation_volume=360;citation_year=2009;citation_issue=26;citation_pmid=19553649;citation_doi=10.1056/NEJMra0805786" /> <meta name="citation_reference" content="citation_journal_title=Nat Commun;citation_author=J. Argemi;citation_author=MU. Latasa;citation_author=SR. Atkinson;citation_title=Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis;citation_pages=3126;citation_volume=10;citation_year=2019;citation_pmid=http://www.n;citation_doi=10.1038/s41467-019-11004-3" /> <meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=A. Aravinthan;citation_author=G. Pietrosi;citation_author=M. Hoare;citation_title=Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease;citation_pages=e72904;citation_volume=8;citation_year=2013;citation_pmid=24086266;citation_doi=10.1371/journal.pone.0072904" /> <meta name="citation_reference" content="citation_journal_title=Gut;citation_author=L. Dubuquoy;citation_author=A. Louvet;citation_author=G. Lassailly;citation_title=Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis;citation_volume=64;citation_year=2015;citation_pmid=25731872;citation_doi=10.1136/gutjnl-2014-308410" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=C. Lackner;citation_author=W. Spindelboeck;citation_author=J. Haybaeck;citation_title=Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease;citation_pages=610-8;citation_volume=66;citation_year=2017;citation_pmid=http://www.n;citation_doi=10.1016/j.jhep.2016.11.011" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=C. Lackner;citation_author=RE. Stauber;citation_author=S. Davies;citation_title=Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease;citation_pages=810-9;citation_volume=75;citation_year=2021;citation_pmid=34126105;citation_doi=10.1016/j.jhep.2021.05.029" /> <meta name="citation_reference" content="citation_journal_title=Liver Int;citation_author=S. Masson;citation_author=I. Emmerson;citation_author=E. Henderson;citation_title=Clinical but not histological factors predict long-term prognosis in patients with histologically advanced non-decompensated alcoholic liver disease;citation_pages=235-42;citation_volume=34;citation_year=2014;citation_pmid=23834275;citation_doi=10.1111/liv.12242" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=D. Degré;citation_author=RE. Stauber;citation_author=G. Englebert;citation_title=Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey’s discriminant function <32;citation_pages=636-42;citation_volume=72;citation_year=2020;citation_pmid=31954208;citation_doi=10.1016/j.jhep.2019.12.023" /> <meta name="citation_reference" content="citation_journal_title=Gut;citation_author=H. Hagström;citation_author=M. Thiele;citation_author=B. Roelstraete;citation_author=J. Söderling;citation_author=JF. Ludvigsson;citation_title=Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients;citation_volume=70;citation_year=2021;citation_pmid=32220902;citation_doi=10.1136/gutjnl-2019-320446" /> <meta name="citation_reference" content="citation_journal_title=BMC Gastroenterol;citation_author=S. Haflidadottir;citation_author=JG. Jonasson;citation_author=H. Norland;citation_title=Long-term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic related fatty liver disease;citation_pages=166;citation_volume=14;citation_year=2014;citation_pmid=25260964;citation_doi=10.1186/1471-230X-14-166" /> <meta name="citation_reference" content="citation_journal_title=Ann Hepatol;citation_author=M. Shoreibah;citation_author=E. Raff;citation_author=J. Bloomer;citation_title=Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver diseas;citation_pages=183-9;citation_volume=15;citation_year=2016;citation_pmid=26845595;citation_doi=10.5604/16652681.1193707" /> <meta name="citation_reference" content="citation_journal_title=Clin Gastroenterol Hepatol;citation_author=A. Mancebo;citation_author=ML. González-Diéguez;citation_author=V. Cadahía;citation_title=Annual incidence of hepatocellular carcinoma among patients with alcoholic cirrhosis and identification of risk groups;citation_pages=95-101;citation_volume=11;citation_year=2013;citation_pmid=http://www.n;citation_doi=10.1016/j.cgh.2012.09.007" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=N. Ganne-Carrié;citation_author=C. Chaffaut;citation_author=V. Bourcier;citation_title=Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis;citation_pages=1274-83;citation_volume=69;citation_year=2018;citation_pmid=30092234;citation_doi=10.1016/j.jhep.2018.07.022" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=GN. Ioannou;citation_author=P. Green;citation_author=KF. Kerr;citation_author=K. Berry;citation_title=Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification;citation_pages=523-33;citation_volume=71;citation_year=2019;citation_pmid=http://www.n;citation_doi=10.1016/j.jhep.2019.05.008" /> <meta name="citation_reference" content="citation_journal_title=Sci Rep;citation_author=K. Lee;citation_author=GH. Choi;citation_author=ES. Jang;citation_author=SH. Jeong;citation_author=JW. Kim;citation_title=A scoring system for predicting hepatocellular carcinoma risk in alcoholic cirrhosis;citation_pages=1717;citation_volume=12;citation_year=2022;citation_pmid=35110551;citation_doi=10.1038/s41598-022-05196-w" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=TD. Sandahl;citation_author=P. Jepsen;citation_author=KL. Thomsen;citation_author=H. Vilstrup;citation_title=Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study;citation_pages=760-4;citation_volume=54;citation_year=2011;citation_pmid=21126790;citation_doi=10.1016/j.jhep.2010.07.016" /> <meta name="citation_reference" content="citation_journal_title=J Gastroenterol Hepatol;citation_author=JY. Lee;citation_author=Y. Cho;citation_author=MH. Hong;citation_title=Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study;citation_pages=747-54;citation_volume=34;citation_year=2019;citation_pmid=30345539;citation_doi=10.1111/jgh.14513" /> <meta name="citation_reference" content="citation_journal_title=J Clin Gastroenterol;citation_author=F. Shirazi;citation_author=AK. Singal;citation_author=RJ. Wong;citation_title=Alcohol-associated cirrhosis and alcoholic hepatitis hospitalization trends in the United States;citation_pages=174-9;citation_volume=55;citation_year=2021;citation_pmid=32520887;citation_doi=10.1097/MCG.0000000000001378" /> <meta name="citation_reference" content="citation_journal_title=Dig Dis Sci;citation_author=SD. Doshi;citation_author=MJ. Stotts;citation_author=RA. Hubbard;citation_author=DS. Goldberg;citation_title=The changing burden of alcoholic hepatitis: rising incidence and associations with age, gender, race, and geography;citation_pages=1707-14;citation_volume=66;citation_year=2021;citation_pmid=32436122;citation_doi=10.1007/s10620-020-06346-8" /> <meta name="citation_reference" content="citation_journal_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_author=E. Nguyen-Khac;citation_author=T. Thevenot;citation_author=MA. Piquet;citation_title=Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis.;citation_pages=1781-1789;citation_volume=365;citation_year=2011;citation_issue=19;citation_pmid=22070475;citation_doi=10.1056/NEJMoa1101214" /> <meta name="citation_reference" content="citation_journal_title=N Engl J Med;citation_author=MR. Thursz;citation_author=P. Richardson;citation_author=M. Allison;citation_title=Prednisolone or pentoxifylline for alcoholic hepatitis;citation_pages=1619-28;citation_volume=372;citation_year=2015;citation_pmid=25901427;citation_doi=10.1056/NEJMoa1412278" /> <meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=E. Hughes;citation_author=LJ. Hopkins;citation_author=R. Parker;citation_title=Survival from alcoholic hepatitis has not improved over time;citation_pages=e0192393;citation_volume=13;citation_year=2018;citation_pmid=29444123;citation_doi=10.1371/journal.pone.0192393" /> <meta name="citation_reference" content="citation_journal_title=Nat Genet;citation_author=S. Buch;citation_author=F. Stickel;citation_author=E. Trépo;citation_title=A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis;citation_pages=1443-8;citation_volume=47;citation_year=2015;citation_pmid=26482880;citation_doi=10.1038/ng.3417" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=H. Innes;citation_author=S. Buch;citation_author=S. Hutchinson;citation_title=Genome-wide association study for alcohol-related cirrhosis identifies risk loci in MARC1 and HNRNPUL1;citation_pages=1276-1289.e7;citation_volume=159;citation_year=2020;citation_pmid=32561361;citation_doi=10.1053/j.gastro.2020.06.014" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=TH. Schwantes-An;citation_author=R. Darlay;citation_author=P. Mathurin;citation_title=Genome-wide association study and meta-analysis on alcohol-associated liver cirrhosis identifies genetic risk factors;citation_volume=73;citation_year=2021;citation_pmid=32853455;citation_doi=10.1002/hep.31535" /> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol;citation_author=AG. Singal;citation_author=H. Manjunath;citation_author=AC. Yopp;citation_title=The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis;citation_pages=325-34;citation_volume=109;citation_year=2014;citation_pmid=24445574;citation_doi=10.1038/ajg.2013.476" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=SR. Atkinson;citation_author=MJ. Way;citation_author=A. McQuillin;citation_author=MY. Morgan;citation_author=MR. Thursz;citation_title=Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis;citation_pages=120-7;citation_volume=67;citation_year=2017;citation_pmid=28161471;citation_doi=10.1016/j.jhep.2017.01.018" /> <meta name="citation_reference" content="citation_journal_title=Liver Int;citation_author=MA. Burza;citation_author=A. Molinaro;citation_author=ML. Attilia;citation_title=PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis;citation_pages=514-20;citation_volume=34;citation_year=2014;citation_pmid=24102786;citation_doi=10.1111/liv.12310" /> <meta name="citation_reference" content="citation_journal_title=J Gastroenterol Hepatol;citation_author=K. Friedrich;citation_author=A. Wannhoff;citation_author=S. Kattner;citation_title=PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival;citation_pages=1477-84;citation_volume=29;citation_year=2014;citation_pmid=25273282;citation_doi=10.1111/jgh.12540" /> <meta name="citation_reference" content="citation_journal_title=PLoS One;citation_author=L. Valenti;citation_author=BM. Motta;citation_author=G. Soardo;citation_title=PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma;citation_pages=e75982;citation_volume=8;citation_year=2013;citation_pmid=24155878;citation_doi=10.1371/journal.pone.0075982" /> <meta name="citation_reference" content="citation_journal_title=Lancet Oncol;citation_author=E. Trépo;citation_author=S. Caruso;citation_author=J. Yang;citation_title=Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study;citation_pages=161-71;citation_volume=23;citation_year=2022;citation_pmid=http://www.n;citation_doi=10.1016/S1470-2045(21)00603-3" /> <meta name="citation_reference" content="citation_journal_title=Gut;citation_author=S. Buch;citation_author=H. Innes;citation_author=PL. Lutz;citation_title=Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study;citation_volume=72;citation_year=2023;citation_pmid=35788059;citation_doi=10.1136/gutjnl-2022-327196" /> <meta name="citation_reference" content="citation_journal_title=Addiction;citation_author=HE. Otete;citation_author=E. Orton;citation_author=J. West;citation_author=KM. Fleming;citation_title=Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis;citation_pages=1932-40;citation_volume=110;citation_year=2015;citation_pmid=26235801;citation_doi=10.1111/add.13081" /> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol;citation_author=G. Askgaard;citation_author=MS. Kjær;citation_author=JS. Tolstrup;citation_title=Opportunities to prevent alcoholic liver cirrhosis in high-risk populations: a systematic review with meta-analysis;citation_pages=221-32;citation_volume=114;citation_year=2019;citation_pmid=30353053;citation_doi=10.1038/s41395-018-0282-6" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=G. Askgaard;citation_author=DA. Leon;citation_author=MS. Kjaer;citation_author=T. Deleuran;citation_author=TA. Gerds;citation_author=JS. Tolstrup;citation_title=Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study;citation_pages=929-37;citation_volume=65;citation_year=2017;citation_pmid=27862159;citation_doi=10.1002/hep.28943" /> <meta name="citation_reference" content="citation_journal_title=Scand J Public Health;citation_author=G. Askgaard;citation_author=JS. Tolstrup;citation_author=MS. Kjær;citation_author=DA. Leon;citation_title=Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis;citation_pages=417-9;citation_volume=47;citation_year=2019;citation_pmid=29528775;citation_doi=10.1177/1403494818763436" /> <meta name="citation_reference" content="citation_journal_title=BMC Public Health;citation_author=PA. Cook;citation_author=M. Morleo;citation_author=D. Billington;citation_title=Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study;citation_pages=532;citation_volume=15;citation_year=2015;citation_pmid=26041363;citation_doi=10.1186/s12889-015-1860-9" /> <meta name="citation_reference" content="citation_journal_title=Liver international : official journal of the International Association for the Study of the Liver;citation_journal_abbrev=Liver Int;citation_author=RP. Myers;citation_author=A. Fong;citation_author=AA. Shaheen;citation_title=Utilization rates, complications and costs of percutaneous liver biopsy: a population-based study including 4275 biopsies.;citation_pages=705-712;citation_volume=28;citation_year=2008;citation_issue=5;citation_pmid=18433397;citation_doi=10.1111/j.1478-3231.2008.01691.x" /> <meta name="citation_reference" content="citation_journal_title=Dig Dis Sci;citation_author=HB. Thomaides-Brears;citation_author=N. Alkhouri;citation_author=D. Allende;citation_title=Incidence of complications from percutaneous biopsy in chronic liver disease: a systematic review and meta-analysis;citation_pages=3366-94;citation_volume=67;citation_year=2022;citation_pmid=34129125;citation_doi=10.1007/s10620-021-07089-w" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=NF. Schwenzer;citation_author=F. Springer;citation_author=C. Schraml;citation_author=N. Stefan;citation_author=J. Machann;citation_author=F. Schick;citation_title=Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance;citation_pages=433-45;citation_volume=51;citation_year=2009;citation_pmid=19604596;citation_doi=10.1016/j.jhep.2009.05.023" /> <meta name="citation_reference" content="citation_journal_title=Cochrane Database Syst Rev;citation_author=CS. Pavlov;citation_author=G. Casazza;citation_author=M. Semenistaia;citation_title=Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease;citation_pages=CD011602;citation_volume=3;citation_year=2016;citation_pmid=26934429;citation_doi=10.1002/14651858.CD011602.pub2" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=M. Thiele;citation_author=BS. Madsen;citation_author=JF. Hansen;citation_author=S. Detlefsen;citation_author=S. Antonsen;citation_author=A. Krag;citation_title=Accuracy of the enhanced liver fibrosis test vs FibroTest, elastography, and indirect markers in detection of advanced fibrosis in patients with alcoholic liver disease;citation_pages=1369-79;citation_volume=154;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1053/j.gastro.2018.01.005" /> <meta name="citation_reference" content="citation_journal_title=BMC Gastroenterol;citation_author=D. Connoley;citation_author=PJ. Patel;citation_author=B. Hogan;citation_title=The enhanced liver fibrosis test maintains its diagnostic and prognostic performance in alcohol-related liver disease: a cohort study;citation_pages=268;citation_volume=21;citation_year=2021;citation_pmid=34182924;citation_doi=10.1186/s12876-021-01795-5" /> <meta name="citation_reference" content="citation_journal_title=Clin Gastroenterol Hepatol;citation_author=L. Legros;citation_author=E. Bardou-Jacquet;citation_author=B. Turlin;citation_title=Transient elastography accurately screens for compensated advanced chronic liver disease in patients with ongoing or recent alcohol withdrawal;citation_pages=1542-1552.e6;citation_volume=20;citation_year=2022;citation_pmid=33588101;citation_doi=10.1016/j.cgh.2021.02.021" /> <meta name="citation_reference" content="citation_journal_title=Cochrane Database Syst Rev;citation_author=CS. Pavlov;citation_author=G. Casazza;citation_author=D. Nikolova;citation_title=Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease;citation_pages=CD010542;citation_volume=1;citation_year=2015;citation_pmid=25612182;citation_doi=10.1002/14651858.CD010542.pub2" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_author=E. Nguyen-Khac;citation_author=M. Thiele;citation_author=C. Voican;citation_title=Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis;citation_pages=614-25;citation_volume=3;citation_year=2018;citation_pmid=29983372;citation_doi=10.1016/S2468-1253(18)30124-9" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=E. Herrmann;citation_author=V. de Lédinghen;citation_author=C. Cassinotto;citation_title=Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis;citation_pages=260-72;citation_volume=67;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1002/hep.29179" /> <meta name="citation_reference" content="citation_journal_title=World journal of gastroenterology : WJG;citation_journal_abbrev=World J Gastroenterol;citation_author=S. Mueller;citation_author=G. Millonig;citation_author=L. Sarovska;citation_title=Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis.;citation_pages=966-972;citation_volume=16;citation_year=2010;citation_issue=8;citation_pmid=20180235;citation_doi=10.3748/wjg.v16.i8.966" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=L. Asphaug;citation_author=M. Thiele;citation_author=A. Krag;citation_author=HO. Melberg;citation_title=Cost-effectiveness of noninvasive screening for alcohol-related liver fibrosis;citation_pages=2093-104;citation_volume=71;citation_year=2020;citation_pmid=31595545;citation_doi=10.1002/hep.30979" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=M. Kjaergaard;citation_author=KP. Lindvig;citation_author=KH. Thorhauge;citation_title=Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease;citation_pages=277-86;citation_volume=79;citation_year=2023;citation_pmid=37088311;citation_doi=10.1016/j.jhep.2023.04.002" /> <meta name="citation_reference" content="citation_journal_title=Sci Rep;citation_author=V. Blanes-Vidal;citation_author=KP. Lindvig;citation_author=M. Thiele;citation_author=ES. Nadimi;citation_author=A. Krag;citation_title=Artificial intelligence outperforms standard blood-based scores in identifying liver fibrosis patients in primary care;citation_pages=2914;citation_volume=12;citation_year=2022;citation_pmid=35190650;citation_doi=10.1038/s41598-022-06998-8" /> <meta name="citation_reference" content="citation_journal_title=J Gastroenterol Hepatol;citation_author=FA. Rhodes;citation_author=P. Trembling;citation_author=J. Panovska-Griffiths;citation_title=Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease;citation_pages=1435-49;citation_volume=36;citation_year=2021;citation_pmid=33171534;citation_doi=10.1111/jgh.15335" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=DN. Rasmussen;citation_author=M. Thiele;citation_author=S. Johansen;citation_title=Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease;citation_pages=1017-25;citation_volume=75;citation_year=2021;citation_pmid=34118335;citation_doi=10.1016/j.jhep.2021.05.037" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=R. de Franchis;citation_title=Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension;citation_pages=743-52;citation_volume=63;citation_year=2015;citation_pmid=26047908;citation_doi=10.1016/j.jhep.2015.05.022" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=S. Augustin;citation_author=M. Pons;citation_author=JB. Maurice;citation_title=Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease;citation_pages=1980-8;citation_volume=66;citation_year=2017;citation_pmid=28696510;citation_doi=10.1002/hep.29363" /> <meta name="citation_reference" content="citation_journal_title=Acta Gastroenterol Belg;citation_author=M. Pizzamiglio;citation_author=A. Weicker;citation_author=C. de Terwangne;citation_author=J. Henrion;citation_author=OS. Descamps;citation_author=M. De Vos;citation_title=Validation of Baveno VI and Expanded-Baveno VI Criteria for predicting gastroesophageal varices in patients with alcoholic and non-alcoholic fatty liver disease;citation_pages=321-9;citation_volume=85;citation_year=2022;citation_pmid=35709776;citation_doi=10.51821/88.2.9553" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=R. de Franchis;citation_author=J. Bosch;citation_author=G. Garcia-Tsao;citation_author=T. Reiberger;citation_author=C. Ripoll;citation_title=Baveno VII - Renewing consensus in portal hypertension;citation_volume=76;citation_year=2022;citation_pmid=35120736;citation_doi=10.1016/j.jhep.2021.12.022" /> <meta name="citation_reference" content="citation_journal_title=Nat Med;citation_author=L. Niu;citation_author=M. Thiele;citation_author=PE. Geyer;citation_title=Noninvasive proteomic biomarkers for alcohol-related liver disease;citation_pages=1277-87;citation_volume=28;citation_year=2022;citation_pmid=http://www.n;citation_doi=10.1038/s41591-022-01850-y" /> <meta name="citation_reference" content="World Health Organization. International Classification of Diseases 11th revision (ICD-11). 2018 https://icd.who.int/browse11/l-m/en." /> <meta name="citation_reference" content="citation_title=Diagnostic and Statistical Manual of Mental Disorders (DSM-5);citation_year=2013" /> <meta name="citation_reference" content="citation_journal_title=Br Med Bull;citation_author=A. Lingford-Hughes;citation_author=B. Watson;citation_author=N. Kalk;citation_author=A. Reid;citation_title=Neuropharmacology of addiction and how it informs treatment;citation_volume=96;citation_year=2010;citation_pmid=21044987;citation_doi=10.1093/bmb/ldq032" /> <meta name="citation_reference" content="citation_journal_title=Lancet Psychiatry;citation_author=GF. Koob;citation_author=ND. Volkow;citation_title=Neurobiology of addiction: a neurocircuitry analysis;citation_pages=760-73;citation_volume=3;citation_year=2016;citation_pmid=27475769;citation_doi=10.1016/S2215-0366(16)00104-8" /> <meta name="citation_reference" content="citation_journal_title=Psychopharmacologia;citation_journal_abbrev=Psychopharmacologia;citation_author=A. Herz;citation_title=Endogenous opioid systems and alcohol addiction.;citation_pages=99-111;citation_volume=129;citation_year=1997;citation_issue=2;citation_pmid=9040115;citation_doi=10.1007/s002130050169" /> <meta name="citation_reference" content="citation_journal_title=Biol Psychiatry;citation_author=P. Trifilieff;citation_author=D. Martinez;citation_title=Blunted dopamine release as a biomarker for vulnerability for substance use disorders;citation_pages=4-5;citation_volume=76;citation_year=2014;citation_pmid=24925889;citation_doi=10.1016/j.biopsych.2014.04.017" /> <meta name="citation_reference" content="citation_journal_title=Mol Psychiatry;citation_author=S. Turton;citation_author=JF. Myers;citation_author=I. Mick;citation_title=Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals;citation_pages=1749-58;citation_volume=25;citation_year=2020;citation_pmid=29942043;citation_doi=10.1038/s41380-018-0107-4" /> <meta name="citation_reference" content="citation_journal_title=Addict Biol;citation_author=JP. Schacht;citation_author=RF. Anton;citation_author=H. Myrick;citation_title=Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review;citation_pages=121-33;citation_volume=18;citation_year=2013;citation_pmid=22574861;citation_doi=10.1111/j.1369-1600.2012.00464.x" /> <meta name="citation_reference" content="citation_journal_title=Neuroscience and biobehavioral reviews;citation_journal_abbrev=Neurosci Biobehav Rev;citation_author=G. Sescousse;citation_author=X. Caldú;citation_author=B. Segura;citation_author=JC. Dreher;citation_title=Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies.;citation_pages=681-96;citation_volume=37;citation_year=2013;citation_pmid=23415703;citation_doi=10.1016/j.neubiorev.2013.02.002" /> <meta name="citation_reference" content="citation_journal_title=Neuropsychopharmacology;citation_author=A. Murphy;citation_author=LJ. Nestor;citation_author=J. McGonigle;citation_title=Acute D3 antagonist GSK598809 selectively enhances neural response during monetary reward anticipation in drug and alcohol dependence;citation_pages=1925-6;citation_volume=42;citation_year=2017;citation_pmid=28701746;citation_doi=10.1038/npp.2017.99" /> <meta name="citation_reference" content="citation_journal_title=Neurosci Biobehav Rev;citation_author=J. Zeng;citation_author=S. Yu;citation_author=H. Cao;citation_author=Y. Su;citation_author=Z. Dong;citation_author=X. Yang;citation_title=Neurobiological correlates of cue-reactivity in alcohol-use disorders: A voxel-wise meta-analysis of fMRI studies;citation_pages=294-310;citation_volume=128;citation_year=2021;citation_pmid=34171325;citation_doi=10.1016/j.neubiorev.2021.06.031" /> <meta name="citation_reference" content="citation_journal_title=Addict Biol;citation_author=KE. Courtney;citation_author=JP. Schacht;citation_author=K. Hutchison;citation_author=DJ. Roche;citation_author=LA. Ray;citation_title=Neural substrates of cue reactivity: association with treatment outcomes and relapse;citation_pages=3-22;citation_volume=21;citation_year=2016;citation_pmid=http://www.n;citation_doi=10.1111/adb.12314" /> <meta name="citation_reference" content="citation_journal_title=Pharmacol Rev;citation_author=GF. Koob;citation_title=Drug addiction: Hyperkatifeia/negative reinforcement as a framework for medications development;citation_pages=163-201;citation_volume=73;citation_year=2021;citation_pmid=33318153;citation_doi=10.1124/pharmrev.120.000083" /> <meta name="citation_reference" content="citation_journal_abbrev=Nat Rev Neurol;citation_author=NM. Zahr;citation_author=KL. Kaufman;citation_author=CG. Harper;citation_title=Clinical and pathological features of alcohol-related brain damage.;citation_pages=284-294;citation_volume=7;citation_year=2011;citation_issue=5;citation_pmid=21487421;citation_doi=10.1038/nrneurol.2011.42" /> <meta name="citation_reference" content="citation_journal_title=Front Psychiatry;citation_author=K. Agarwal;citation_author=P. Manza;citation_author=M. Chapman;citation_title=Inflammatory markers in substance use and mood disorders: a neuroimaging perspective;citation_pages=863734;citation_volume=13;citation_year=2022;citation_pmid=35558424;citation_doi=10.3389/fpsyt.2022.863734" /> <meta name="citation_reference" content="citation_journal_title=Drug Alcohol Depend;citation_author=MA. Parvaz;citation_author=RA. Rabin;citation_author=F. Adams;citation_author=RZ. Goldstein;citation_title=Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies;citation_pages=109319;citation_volume=232;citation_year=2022;citation_pmid=35077955;citation_doi=10.1016/j.drugalcdep.2022.109319" /> <meta name="citation_reference" content="citation_journal_title=Alcohol;citation_author=EV. Sullivan;citation_author=A. Pfefferbaum;citation_title=Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia;citation_pages=44-55;citation_volume=107;citation_year=2023;citation_pmid=35781021;citation_doi=10.1016/j.alcohol.2022.06.002" /> <meta name="citation_reference" content="National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis, assessment and management of harmful drinking (high-risk drinking) and alcohol dependence (clinical guideline CG115). 2011. https://www.nice.org.uk/guidance/cg115." /> <meta name="citation_reference" content="citation_journal_title=Addiction (Abingdon, England);citation_journal_abbrev=Addiction;citation_author=TH. Bien;citation_author=WR. Miller;citation_author=JS. Tonigan;citation_title=Brief interventions for alcohol problems: a review.;citation_pages=315-335;citation_volume=88;citation_year=1993;citation_issue=3;citation_pmid=8461850;citation_doi=10.1111/j.1360-0443.1993.tb00820.x" /> <meta name="citation_reference" content="citation_journal_title=Cochrane Database Syst Rev;citation_author=EF. Kaner;citation_author=FR. Beyer;citation_author=C. Muirhead;citation_title=Effectiveness of brief alcohol interventions in primary care populations;citation_pages=CD004148;citation_volume=2;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1002/14651858.CD004148.pub4" /> <meta name="citation_reference" content="citation_journal_title=Alcohol Clin Exp Res;citation_author=G. Addolorato;citation_author=A. Mirijello;citation_author=L. Leggio;citation_title=Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center;citation_pages=1601-8;citation_volume=37;citation_year=2013;citation_pmid=23578009;citation_doi=10.1111/acer.12117" /> <meta name="citation_reference" content="citation_journal_title=Cochrane Database Syst Rev;citation_author=JF. Kelly;citation_author=K. Humphreys;citation_author=M. Ferri;citation_title=Alcoholics Anonymous and other 12-step programs for alcohol use disorder;citation_pages=CD012880;citation_volume=3;citation_year=2020;citation_pmid=32159228;citation_doi=10.1002/14651858.CD012880.pub2" /> <meta name="citation_reference" content="citation_journal_title=J Psychopharmacol;citation_author=AR. Lingford-Hughes;citation_author=S. Welch;citation_author=L. Peters;citation_author=DJ. Nutt;citation_title=BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP;citation_volume=26;citation_year=2012;citation_pmid=22628390;citation_doi=10.1177/0269881112444324" /> <meta name="citation_reference" content="National Clinical Guideline Centre. Alcohol use disorders: diagnosis and clinical management of alcohol-related physical complications. 2010. https://www.nice.org.uk/guidance/cg100/evidence/full-guideline-pdf-134509213." /> <meta name="citation_reference" content="citation_journal_title=Journal of Neurology, Neurosurgery & Psychiatry;citation_journal_abbrev=J. Neurol. Neurosurg. Psychiatry;citation_author=D. Caine;citation_author=GM. Halliday;citation_author=JJ. Kril;citation_author=CG. Harper;citation_title=Operational criteria for the classification of chronic alcoholics: identification of Wernicke's encephalopathy.;citation_pages=51-60;citation_volume=62;citation_year=1997;citation_issue=1;citation_pmid=9010400;citation_doi=10.1136/jnnp.62.1.51" /> <meta name="citation_reference" content="citation_journal_title=Alcohol Alcohol;citation_author=AD. Thomson;citation_author=EJ. Marshall;citation_author=D. Bell;citation_title=Time to act on the inadequate management of Wernicke’s encephalopathy in the UK;citation_volume=48;citation_year=2013;citation_pmid=23065147;citation_doi=10.1093/alcalc/ags111" /> <meta name="citation_reference" content="citation_journal_title=Lancet Psychiatry;citation_author=R. Agabio;citation_author=JM. Sinclair;citation_author=G. Addolorato;citation_title=Baclofen for the treatment of alcohol use disorder: the Cagliari Statement;citation_pages=957-60;citation_volume=5;citation_year=2018;citation_pmid=30413394;citation_doi=10.1016/S2215-0366(18)30303-1" /> <meta name="citation_reference" content="citation_journal_title=Addiction;citation_author=AK. Rose;citation_author=A. Jones;citation_title=Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis;citation_volume=113;citation_year=2018;citation_pmid=29479827;citation_doi=10.1111/add.14191" /> <meta name="citation_reference" content="citation_journal_title=Eur Neuropsychopharmacol;citation_author=M. Pierce;citation_author=A. Sutterland;citation_author=EM. Beraha;citation_author=K. Morley;citation_author=W. van den Brink;citation_title=Efficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: A systematic review and meta-analysis;citation_pages=795-806;citation_volume=28;citation_year=2018;citation_pmid=29934090;citation_doi=10.1016/j.euroneuro.2018.03.017" /> <meta name="citation_reference" content="citation_journal_title=Acta Psychiatr Scand;citation_author=T. Bschor;citation_author=J. Henssler;citation_author=M. Müller;citation_author=C. Baethge;citation_title=Baclofen for alcohol use disorder-a systematic meta-analysis;citation_pages=232-42;citation_volume=138;citation_year=2018;citation_pmid=29888478;citation_doi=10.1111/acps.12905" /> <meta name="citation_reference" content="citation_journal_title=Cochrane Database Syst Rev;citation_author=S. Minozzi;citation_author=R. Saulle;citation_author=S. Rösner;citation_title=Baclofen for alcohol use disorder;citation_pages=CD012557;citation_volume=11;citation_year=2018;citation_pmid=30484285" /> <meta name="citation_reference" content="citation_journal_title=Am J Psychiatry;citation_author=VI. Reus;citation_author=LJ. Fochtmann;citation_author=O. Bukstein;citation_title=The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder;citation_pages=86-90;citation_volume=175;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1176/appi.ajp.2017.1750101" /> <meta name="citation_reference" content="citation_journal_title=Nat Rev Gastroenterol Hepatol;citation_author=JP. Arab;citation_author=M. Izzy;citation_author=L. Leggio;citation_author=R. Bataller;citation_author=VH. Shah;citation_title=Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation;citation_pages=45-59;citation_volume=19;citation_year=2022;citation_pmid=34725498;citation_doi=10.1038/s41575-021-00527-0" /> <meta name="citation_reference" content="citation_journal_title=Lancet;citation_journal_abbrev=Lancet;citation_author=G. Addolorato;citation_author=L. Leggio;citation_author=A. Ferrulli;citation_title=Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study.;citation_pages=1915-1922;citation_volume=370;citation_year=2007;citation_issue=9603;citation_pmid=18068515;citation_doi=10.1016/S0140-6736(07)61814-5" /> <meta name="citation_reference" content="NHS Digital. Statistics on alcohol, England 2021. 2021. https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-alcohol/2021." /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=S. Rogal;citation_author=A. Youk;citation_author=H. Zhang;citation_title=Impact of alcohol use disorder treatment on clinical outcomes among patients with cirrhosis;citation_pages=2080-92;citation_volume=71;citation_year=2020;citation_pmid=31758811;citation_doi=10.1002/hep.31042" /> <meta name="citation_reference" content="citation_journal_title=Clin Gastroenterol Hepatol;citation_author=AGL. Vannier;citation_author=EM. Przybyszewski;citation_author=J. Shay;citation_title=Psychotherapy for alcohol use disorder is associated with reduced risk of incident alcohol-associated liver disease;citation_pages=1571-1580.e7;citation_volume=21;citation_year=2023;citation_pmid=35964893;citation_doi=10.1016/j.cgh.2022.08.001" /> <meta name="citation_reference" content="citation_journal_title=Aliment Pharmacol Ther;citation_author=ET. Goh;citation_author=MY. Morgan;citation_title=Review article: pharmacotherapy for alcohol dependence - the why, the what and the wherefore;citation_pages=865-82;citation_volume=45;citation_year=2017;citation_pmid=28220511;citation_doi=10.1111/apt.13965" /> <meta name="citation_reference" content="Public Health England. Developing pathways for referring patients from secondary care to specialist alcohol treatment. 2018. https://www.gov.uk/government/publications/developing-pathways-for-alcohol-treatment/developing-pathways-for-referring-patients-from-secondary-care-to-specialist-alcohol-treatment." /> <meta name="citation_reference" content="citation_journal_title=Clin Gastroenterol Hepatol;citation_author=A. Khan;citation_author=A. Tansel;citation_author=DL. White;citation_title=Efficacy of psychosocial interventions in inducing and maintaining alcohol abstinence in patients with chronic liver disease: a systematic review;citation_pages=191-202.e1, 4, quiz e20;citation_volume=14;citation_year=2016;citation_pmid=26256464;citation_doi=10.1016/j.cgh.2015.07.047" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_author=AF. DiMartini;citation_author=L. Leggio;citation_author=AK. Singal;citation_title=Barriers to the management of alcohol use disorder and alcohol-associated liver disease: strategies to implement integrated care models;citation_pages=186-95;citation_volume=7;citation_year=2022;citation_pmid=35026172;citation_doi=10.1016/S2468-1253(21)00191-6" /> <meta name="citation_reference" content="Public Health England. Alcohol care team: core service descriptor. 2019. https://www.longtermplan.nhs.uk/wp-content/uploads/2019/11/ACT-core-service-descriptor-051119.pdf." /> <meta name="citation_reference" content="citation_title=Exploring the management of alcohol problems in Deep End practices in Scotland.;citation_author=A. Mohan;citation_author=D. Mitchell;citation_author=C. Sharp;citation_year=2022" /> <meta name="citation_reference" content="citation_journal_title=Alcohol Alcohol;citation_author=T. Phillips;citation_author=C. Huang;citation_author=E. Roberts;citation_author=C. Drummond;citation_title=Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship;citation_pages=28-33;citation_volume=56;citation_year=2021;citation_pmid=32885812;citation_doi=10.1093/alcalc/agaa086" /> <meta name="citation_reference" content="citation_journal_title=Journal of hepatology;citation_journal_abbrev=J Hepatol;citation_author=JM. Mato;citation_author=J. Cámara;citation_author=J. Fernández de Paz;citation_title=S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.;citation_pages=1081-1089;citation_volume=30;citation_year=1999;citation_issue=6;citation_pmid=10406187;citation_doi=10.1016/S0168-8278(99)80263-3" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_author=M. Israelsen;citation_author=BS. Madsen;citation_author=N. Torp;citation_title=Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial;citation_pages=523-32;citation_volume=8;citation_year=2023;citation_pmid=36893774;citation_doi=10.1016/S2468-1253(23)00010-9" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=P. Mathurin;citation_author=M. Thursz;citation_title=Endpoints and patient stratification in clinical trials for alcoholic hepatitis;citation_pages=314-8;citation_volume=70;citation_year=2019;citation_pmid=30658732;citation_doi=10.1016/j.jhep.2018.11.005" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=A. Louvet;citation_author=MR. Thursz;citation_author=DJ. Kim;citation_title=Corticosteroids reduce risk of death within 28 days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo-a meta-analysis of individual data from controlled trials;citation_pages=458-468.e8;citation_volume=155;citation_year=2018;citation_pmid=29738698;citation_doi=10.1053/j.gastro.2018.05.011" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=N. Vergis;citation_author=SR. Atkinson;citation_author=S. Knapp;citation_title=In patients with severe alcoholic hepatitis, prednisolone increases susceptibility to infection and infection-related mortality, and is associated with high circulating levels of bacterial DNA;citation_pages=1068-1077.e4;citation_volume=152;citation_year=2017;citation_pmid=28043903;citation_doi=10.1053/j.gastro.2016.12.019" /> <meta name="citation_reference" content="citation_journal_title=Aliment Pharmacol Ther;citation_author=EH. Forrest;citation_author=N. Storey;citation_author=R. Sinha;citation_title=Baseline neutrophil-to-lymphocyte ratio predicts response to corticosteroids and is associated with infection and renal dysfunction in alcoholic hepatitis;citation_pages=442-53;citation_volume=50;citation_year=2019;citation_pmid=31313853;citation_doi=10.1111/apt.15335" /> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol;citation_author=SR. Atkinson;citation_author=JI. Grove;citation_author=S. Liebig;citation_title=In severe alcoholic hepatitis, serum keratin-18 fragments are diagnostic, prognostic, and theragnostic biomarkers;citation_pages=1857-68;citation_volume=115;citation_year=2020;citation_pmid=33156105;citation_doi=10.14309/ajg.0000000000000912" /> <meta name="citation_reference" content="citation_journal_title=American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons;citation_journal_abbrev=Am J Transplant;citation_author=P. Burra;citation_author=M. Senzolo;citation_author=R. Adam;citation_title=Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry).;citation_pages=138-148;citation_volume=10;citation_year=2010;citation_issue=1;citation_pmid=19951276;citation_doi=10.1111/j.1600-6143.2009.02869.x" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=E. Pose;citation_author=A. Torrents;citation_author=E. Reverter;citation_title=A notable proportion of liver transplant candidates with alcohol-related cirrhosis can be delisted because of clinical improvement;citation_pages=275-83;citation_volume=75;citation_year=2021;citation_pmid=33746085;citation_doi=10.1016/j.jhep.2021.02.033" /> <meta name="citation_reference" content="citation_journal_title=Gastroenterology;citation_author=WR. Kim;citation_author=A. Mannalithara;citation_author=JK. Heimbach;citation_title=MELD 3.0: The model for end-stage liver disease updated for the modern era;citation_pages=1887-1895.e4;citation_volume=161;citation_year=2021;citation_pmid=34481845;citation_doi=10.1053/j.gastro.2021.08.050" /> <meta name="citation_reference" content="citation_journal_title=Gut;citation_author=J. Neuberger;citation_author=A. Gimson;citation_author=M. Davies;citation_title=Selection of patients for liver transplantation and allocation of donated livers in the UK;citation_volume=57;citation_year=2008;citation_pmid=17895356;citation_doi=10.1136/gut.2007.131730" /> <meta name="citation_reference" content="citation_journal_title=BMC Gastroenterol;citation_author=L. Chuncharunee;citation_author=N. Yamashiki;citation_author=A. Thakkinstian;citation_author=A. Sobhonslidsuk;citation_title=Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease: a systematic review and meta-analysis;citation_pages=150;citation_volume=19;citation_year=2019;citation_pmid=31438857;citation_doi=10.1186/s12876-019-1050-9" /> <meta name="citation_reference" content="citation_journal_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_author=P. Mathurin;citation_author=C. Moreno;citation_author=D. Samuel;citation_title=Early liver transplantation for severe alcoholic hepatitis.;citation_pages=1790-1800;citation_volume=365;citation_year=2011;citation_issue=19;citation_pmid=22070476;citation_doi=10.1056/NEJMoa1105703" /> <meta name="citation_reference" content="citation_journal_title=Lancet Gastroenterol Hepatol;citation_author=A. Louvet;citation_author=J. Labreuche;citation_author=C. Moreno;citation_title=Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study;citation_pages=416-25;citation_volume=7;citation_year=2022;citation_pmid=35202597;citation_doi=10.1016/S2468-1253(21)00430-1" /> <meta name="citation_reference" content="citation_journal_title=J Hepatol;citation_author=EH. Forrest;citation_author=SR. Atkinson;citation_author=P. Richardson;citation_title=Application of prognostic scores in the STOPAH trial: Discriminant function is no longer the optimal scoring system in alcoholic hepatitis;citation_pages=511-8;citation_volume=68;citation_year=2018;citation_pmid=http://www.n;citation_doi=10.1016/j.jhep.2017.11.017" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=J. Musto;citation_author=D. Stanfield;citation_author=D. Ley;citation_author=MR. Lucey;citation_author=J. Eickhoff;citation_author=JP. Rice;citation_title=Recovery and outcomes of patients denied early liver transplantation for severe alcohol-associated hepatitis;citation_pages=104-14;citation_volume=75;citation_year=2022;citation_pmid=34387875;citation_doi=10.1002/hep.32110" /> <meta name="citation_reference" content="citation_journal_title=JAMA Netw Open;citation_author=MS. Anderson;citation_author=VSM. Valbuena;citation_author=CS. Brown;citation_title=Association of COVID-19 with new waiting list registrations and liver transplantation for alcoholic hepatitis in the United States;citation_pages=2131132e;citation_volume=4;citation_year=2021;citation_pmid=34698851;citation_doi=10.1001/jamanetworkopen.2021.31132" /> <meta name="citation_reference" content="citation_journal_title=Clin Gastroenterol Hepatol;citation_author=CA. Philips;citation_author=A. Pande;citation_author=SM. Shasthry;citation_title=Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study;citation_pages=600-2;citation_volume=15;citation_year=2017;citation_pmid=http://www.n;citation_doi=10.1016/j.cgh.2016.10.029" /> <meta name="citation_reference" content="citation_journal_title=J Lipid Res;citation_author=Y. Wang;citation_author=W. Lin;citation_author=JE. Brown;citation_title=25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes;citation_pages=100063;citation_volume=62;citation_year=2021;citation_pmid=33705741;citation_doi=10.1016/j.jlr.2021.100063" /> <meta name="citation_reference" content="citation_journal_title=Hepatology;citation_author=JP. Arab;citation_author=TS. Sehrawat;citation_author=DA. Simonetto;citation_title=An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis;citation_pages=441-53;citation_volume=72;citation_year=2020;citation_pmid=31774566;citation_doi=10.1002/hep.31046" /> <meta name="citation_reference" content="citation_journal_title=Am J Gastroenterol;citation_author=AK. Singal;citation_author=R. Bataller;citation_author=J. Ahn;citation_author=PS. Kamath;citation_author=VH. Shah;citation_title=ACG clinical guideline: alcoholic liver disease;citation_pages=175-94;citation_volume=113;citation_year=2018;citation_pmid=29336434;citation_doi=10.1038/ajg.2017.469" /> <meta name="citation_reference" content="citation_journal_title=Ann Hepatol;citation_author=JP. Arab;citation_author=JP. Roblero;citation_author=J. Altamirano;citation_title=Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH);citation_pages=518-35;citation_volume=18;citation_year=2019;citation_pmid=31053546;citation_doi=10.1016/j.aohep.2019.04.005" /> <meta name="twitter:title" content="Advances in the understanding and management of alcohol-related liver disease" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:description" content="Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality. Epidemiological trends indicate recent and predicted increases in the burden of disease. Disease progression is driven by continued alcohol exposure on a background of genetic predisposition together with environmental cofactors. Most individuals present with advanced disease despite a long history of excessive alcohol consumption and multiple missed opportunities to intervene. Increasing evidence supports the use of non-invasive tests to screen for and identify disease at earlier stages. There is a definite role for public health measures to reduce the overall burden of disease. At an individual level, however, the ability to influence subsequent disease course by modifying alcohol consumption or the underlying pathogenic mechanisms remains limited due to a comparative lack of effective, disease-modifying medical interventions. Abstinence from alcohol is the key determinant of outcome in established ALD and the cornerstone of clinical management. In those with decompensated ALD, liver transplant has a clear role. There is consensus that abstinence from alcohol for an arbitrary period should not be the sole determinant in a decision to transplant. An increasing understanding of the mechanisms by which alcohol causes liver disease in susceptible individuals offers the prospect of new therapeutic targets for disease-modifying drugs. Successful translation will require significant public and private investment in a disease area which has traditionally been underfunded when compared to its overall prevalence." /> <meta name="og-title" property="og:title" content="Advances in the understanding and management of alcohol-related liver disease" /> <meta name="og-url" property="og:url" content="https://www.bmj.com/content/383/bmj-2023-077090" /> <meta name="og-site-name" property="og:site_name" content="The BMJ" /> <meta name="og-description" property="og:description" content="Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality. Epidemiological trends indicate recent and predicted increases in the burden of disease. Disease progression is driven by continued alcohol exposure on a background of genetic predisposition together with environmental cofactors. Most individuals present with advanced disease despite a long history of excessive alcohol consumption and multiple missed opportunities to intervene. Increasing evidence supports the use of non-invasive tests to screen for and identify disease at earlier stages. There is a definite role for public health measures to reduce the overall burden of disease. At an individual level, however, the ability to influence subsequent disease course by modifying alcohol consumption or the underlying pathogenic mechanisms remains limited due to a comparative lack of effective, disease-modifying medical interventions. Abstinence from alcohol is the key determinant of outcome in established ALD and the cornerstone of clinical management. In those with decompensated ALD, liver transplant has a clear role. There is consensus that abstinence from alcohol for an arbitrary period should not be the sole determinant in a decision to transplant. An increasing understanding of the mechanisms by which alcohol causes liver disease in susceptible individuals offers the prospect of new therapeutic targets for disease-modifying drugs. Successful translation will require significant public and private investment in a disease area which has traditionally been underfunded when compared to its overall prevalence." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og:image" property="og:image" content="https://www.bmj.com/sites/default/files/highwire/bmj/387/8449.cover-source.jpg"/> <meta name="twitter:card" content="summary_large_image"><meta name="twitter:image" property="twitter:image" content="https://www.bmj.com/sites/default/files/sites/defautl/files/attachments/bmj-article/2023/11/thum077090_f1.large_.jpg"><meta name="twitter:title" content="Advances in the understanding and management of alcohol-related liver disease" /><link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/383/bmj-2023-077090.full.txt" /> <meta name="generator" content="Drupal 7 (http://drupal.org)" /> <link rel="canonical" href="https://www.bmj.com/content/383/bmj-2023-077090" /> <link 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class='highwire-cite-article-type'>Clinical Review</span> <span class='bmj-series-title'>State of the Art Review</span> <h1 class="highwire-cite-title" id="page-title">Advances in the understanding and management of alcohol-related liver disease</h1> <span class='highwire-cite-journal'>BMJ</span> <span class='highwire-cite-published-year'>2023</span>; <span class='highwire-cite-volume-issue'>383</span> <span class='highwire-cite-doi'> doi: <a href="https://doi.org/10.1136/bmj-2023-077090">https://doi.org/10.1136/bmj-2023-077090</a></span> <span class='highwire-cite-date'>(Published 20 November 2023)</span> <span class='highwire-cite-article-as'> Cite this as: <span class="italic">BMJ</span> 2023;383:e077090 </span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs pane-panels-ajax-tab-tabs" > <div class="pane-content"> <ul class="tabs inline panels-ajax-tab"><li class="first"><a title="Article Tab - Article" 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class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_bmj_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://www.bmj.com/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_bmj_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view "><span class="highwire-journal-article-marker-start"></span><div class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Mark Thursz</span><span class="contrib-role">, professor of hepatology</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">1</a>, </li><li class="last" id="contrib-2"><span class="name">Anne Lingford-Hughes</span><span class="contrib-role">, professor of addiction biology</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">2</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>1</sup>Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK</address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>2</sup>Department of Brain Sciences, Imperial College London, London, UK</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Correspondence to: M Thursz <span class="em-link"><span class="em-addr">m.thursz{at}imperial.ac.uk</span></span></li></ol></div><div class="section abstract" id="abstract-1"><h2 class="">Abstract</h2><p id="p-1">Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality. Epidemiological trends indicate recent and predicted increases in the burden of disease. Disease progression is driven by continued alcohol exposure on a background of genetic predisposition together with environmental cofactors. Most individuals present with advanced disease despite a long history of excessive alcohol consumption and multiple missed opportunities to intervene. Increasing evidence supports the use of non-invasive tests to screen for and identify disease at earlier stages. There is a definite role for public health measures to reduce the overall burden of disease. At an individual level, however, the ability to influence subsequent disease course by modifying alcohol consumption or the underlying pathogenic mechanisms remains limited due to a comparative lack of effective, disease-modifying medical interventions. Abstinence from alcohol is the key determinant of outcome in established ALD and the cornerstone of clinical management. In those with decompensated ALD, liver transplant has a clear role. There is consensus that abstinence from alcohol for an arbitrary period should not be the sole determinant in a decision to transplant. An increasing understanding of the mechanisms by which alcohol causes liver disease in susceptible individuals offers the prospect of new therapeutic targets for disease-modifying drugs. Successful translation will require significant public and private investment in a disease area which has traditionally been underfunded when compared to its overall prevalence.</p></div><div class="section intro" id="sec-1"><h2 class="">Introduction</h2><p id="p-3">Alcohol-related liver disease (ALD) encompasses a spectrum of clinical presentations and histopathological lesions attributable to the effects of excess alcohol consumption on the liver. The development of steatosis with excessive alcohol consumption occurs in up to 90% of individuals.<a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a><a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a> In a subgroup of patients the development of steatosis is accompanied by the development of ballooned cells, hepatocyte death, and a predominantly neutrophilic lobular inflammation—defining the histological lesion of steatohepatitis due to ALD.<a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a> This may progress to fibrosis and ultimately cirrhosis with the concomitant risk of developing decompensated liver disease and hepatocellular carcinoma. A proportion of patients may present with the distinct clinical syndrome of alcohol-related hepatitis (AH) characterized by the rapid onset of jaundice and other features of liver failure in the context of chronic, ongoing, heavy alcohol use and carries a high risk of short term mortality.<a id="xref-ref-3-2" class="xref-bibr" href="#ref-3">3</a><a id="xref-ref-4-1" class="xref-bibr" href="#ref-4">4</a></p><p id="p-4">The term “alcoholic” is pejorative and associated with significant stigma. This has been recognized by specialists and specialist bodies, which have sought to address it through a change in terminology. The European Association for Study of the Liver (EASL) has recommended use of the term “alcohol-related,”<a id="xref-ref-3-3" class="xref-bibr" href="#ref-3">3</a> while the American Associated for the Study of Liver Disease (AASLD) advocates the term “alcohol-associated.”<a id="xref-ref-5-1" class="xref-bibr" href="#ref-5">5</a> The terminology used in this article is defined in <a id="xref-table-wrap-1-1" class="xref-table" href="#T1">table 1</a>. </p><div id="T1" class="table pos-float"><div class="table"><div class="table-caption"><span class="table-label">Table 1</span> <p id="p-5" class="first-child">Recommended terms and their abbreviations</p><div class="sb-div caption-clear"></div></div><div class="table-inline"><div class="callout"><span>View this table:</span><ul class="callout-links"><li><a href="/highwire/markup/1090001/expansion?width=1000&height=500&iframe=true&postprocessors=highwire_figures%2Chighwire_math" class="colorbox colorbox-load table-expand-popup" rel="gallery-fragment-tables">View popup</a></li><li><a href="" class="table-expand-inline" data-table-url="/highwire/markup/1090001/expansion?postprocessors=highwire_figures%2Chighwire_math">View inline</a></li></ul></div></div></div><div></div></div><p id="p-7">In this review we have tried to summarize recent developments in the understanding of ALD from a public health perspective through to our biological understanding of the disease pathogenesis. We have summarized areas of clinical management, highlighting the prioritization of achieving alcohol abstinence, which may be of interest to a wide range of primary and secondary care physicians.</p></div><div class="section other1" id="sec-2"><h2 class="">Sources and selection criteria</h2><p id="p-8">The MESH search terms “Fatty Liver, Alcoholic,” “Hepatitis, Alcoholic,” “Liver Cirrhosis, Alcoholic,” and “Liver Diseases, Alcoholic” were used as a backbone in PubMed searches to identify relevant articles published between 1960 and May 2023. Where relevant, these were combined using negative logic with the MESH term “Fatty Liver, Non-alcoholic” to avoid retrieving articles related to non-alcohol related fatty liver disease. This backbone query was supplemented with specific terms pertaining to the key topic of each subsection. Results were filtered to include primary research articles, clinical trials, systematic reviews, meta-analyses, and guidelines published in the English language. We prioritized publications within the past decade but also included older articles that were considered landmark trials that changed the treatment paradigm of ALD and alcohol use disorder (AUD). We excluded articles published in non-peer reviewed journals, case reports, and case series.</p></div><div class="section other2" id="sec-3"><h2 class="">Epidemiology</h2><p id="p-9">Alcohol consumption is a risk factor for myriad acute and chronic health issues. Analyses for the Global Burden of Disease Study indicate that in 2016 alcohol use was the seventh leading risk factor for death and disability-adjusted life-years,<a id="xref-ref-6-1" class="xref-bibr" href="#ref-6">6</a> with alcohol use disorders estimated to have an age standardised prevalence of 1321 per 100 000 people.<a id="xref-ref-7-1" class="xref-bibr" href="#ref-7">7</a> In 2017 cirrhosis caused by ALD had an estimated global age-standardised prevalence of 320 per 100 000 and was responsible for 27.3% of the annual 1.32 million cirrhosis-related deaths.<a id="xref-ref-8-1" class="xref-bibr" href="#ref-8">8</a> ALD is the primary etiology in a substantial proportion of liver transplants—36.7% in the US in 2016<a id="xref-ref-9-1" class="xref-bibr" href="#ref-9">9</a> and around 40% in Europe in 2020.<a id="xref-ref-10-1" class="xref-bibr" href="#ref-10">10</a> In the UK recent National Health Service Blood and Transplant figures indicate that alcohol was the primary cause of liver disease in 27% of elective transplants.<a id="xref-ref-11-1" class="xref-bibr" href="#ref-11">11</a></p><p id="p-10">There is a strong correlation between population levels of alcohol consumption and the incidence and prevalence of ALD.<a id="xref-ref-12-1" class="xref-bibr" href="#ref-12">12</a> Changes in population-level drinking behavior preface disease epidemiology. At a global level, per capita alcohol consumption has increased significantly over the past 30 years with further increases predicted.<a id="xref-ref-13-1" class="xref-bibr" href="#ref-13">13</a> These predictions show regional variation, and, while drinking behavior in the European region may remain stable, marked increases have been forecast in the Americas without policy intervention.<a id="xref-ref-13-2" class="xref-bibr" href="#ref-13">13</a> Modeling studies indicate that in the US this could translate into an 84% increase in the age-standardised mortality due to ALD.<a id="xref-ref-14-1" class="xref-bibr" href="#ref-14">14</a> Emerging data suggest that the covid-19 pandemic may have served to entrench drinking behaviors with an increase in alcohol consumption seen in those with high risk drinking before the pandemic in the US<a id="xref-ref-15-1" class="xref-bibr" href="#ref-15">15</a> and Europe.<a id="xref-ref-16-1" class="xref-bibr" href="#ref-16">16</a><a id="xref-ref-17-1" class="xref-bibr" href="#ref-17">17</a></p></div><div class="section other3" id="sec-4"><h2 class="">The role of public health in tackling alcohol-related harm</h2><p id="p-11">Given the strong links between alcohol consumption and ALD at a population level, there is a strong rationale for evidence based and effective public health measures to reduce alcohol-related harms. Policies are in place to restrict access, such as where and who can purchase alcohol, pricing and taxation, and advertising bans.<a id="xref-ref-18-1" class="xref-bibr" href="#ref-18">18</a><a id="xref-ref-19-1" class="xref-bibr" href="#ref-19">19</a> Notably, although education about alcohol and its harms is popular, delivered alone without other interventions it shows limited evidence of effectiveness.<a id="xref-ref-20-1" class="xref-bibr" href="#ref-20">20</a></p><p id="p-12">There is a wealth of evidence showing that selling alcohol for a minimum unit price (MUP) results in reductions in alcohol consumption and harms.<a id="xref-ref-21-1" class="xref-bibr" href="#ref-21">21</a> In the UK, an MUP of 50 pence/unit of alcohol (8 g) was enacted in Scotland in May 2018 (after a lengthy legal challenge by the alcohol industry) followed by Wales in 2020. Consultations are ongoing about an MUP in Northern Ireland, while England has no plans to introduce the policy. Evaluations of the impact in Scotland and Wales have reported a decrease in amount of alcohol purchased, use, and heavy drinking.<a id="xref-ref-22-1" class="xref-bibr" href="#ref-22">22</a> However, reduction in alcohol harms is not universal, with studies variously indicating no reduction in consumption in younger men or men living in more deprived areas,<a id="xref-ref-23-1" class="xref-bibr" href="#ref-23">23</a> no reduction in emergency department attendance,<a id="xref-ref-24-1" class="xref-bibr" href="#ref-24">24</a> and unaltered consumption or severity of alcohol dependence among people drinking at harmful levels.<a id="xref-ref-25-1" class="xref-bibr" href="#ref-25">25</a> Further, not all changes were beneficial: reduced spending on food and utilities and increased borrowing were seen in those drinking at harmful levels who struggled to afford their alcohol.<a id="xref-ref-25-2" class="xref-bibr" href="#ref-25">25</a> Improvements in other alcohol related harms after introduction of an MUP took a few years to accrue in Canada, but reductions in numbers of patients discharged in Glasgow with alcohol-related liver disease have already been reported.<a id="xref-ref-26-1" class="xref-bibr" href="#ref-26">26</a><a id="xref-ref-27-1" class="xref-bibr" href="#ref-27">27</a></p></div><div class="section other4" id="sec-5"><h2 class="">Pathophysiology of alcohol-related liver disease</h2><div id="sec-6" class="subsection"><h3>Intestinal microbiome and gut barrier function (<a id="xref-fig-1-1" class="xref-fig" href="#F1">fig 1</a>)</h3><div id="F1" class="fig pos-float type-figure odd"><div class="fig-inline"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F1.large.jpg?width=800&height=600" title="Microbial dysbiosis in the intestine. (1) Alcohol is converted to acetaldehyde in intestinal epithelial cells. Acetaldehyde induces cellular damage, including proteins that maintain tight junctions between epithelial cells, leading to loss of mucosal integrity. (2) Multiple changes in the composition of the intestinal microbiome are observed in patients with alcohol-related liver disease and alcohol-related hepatitis. (3) Dysbiosis of the microbiome leads to further damage to the epithelial barrier and loss of mucosal integrity. (4) Bacterial products, including lipopolysaccharides and toxins such as the Enterococcus faecalis cytolysin toxin cross the damaged epithelium into the mesenchymal blood vessels and subsequently reach the liver via the portal venous system. (5) Intact bacteria may breach the epithelial barrier and be phagocytosed by monocytes or neutrophils. Failure to mount an effective oxidative burst in phagocytic cells then allows dissemination of bacteria through the circulation. " class="colorbox fragment-images colorbox-load" rel="gallery-fragment-images" data-figure-caption="<div class="highwire-markup"><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label">Fig 1</span> <p id="p-13" class="first-child">Microbial dysbiosis in the intestine. (1) Alcohol is converted to acetaldehyde in intestinal epithelial cells. Acetaldehyde induces cellular damage, including proteins that maintain tight junctions between epithelial cells, leading to loss of mucosal integrity. (2) Multiple changes in the composition of the intestinal microbiome are observed in patients with alcohol-related liver disease and alcohol-related hepatitis. (3) Dysbiosis of the microbiome leads to further damage to the epithelial barrier and loss of mucosal integrity. (4) Bacterial products, including lipopolysaccharides and toxins such as the <em>Enterococcus faecalis</em> cytolysin toxin cross the damaged epithelium into the mesenchymal blood vessels and subsequently reach the liver via the portal venous system. (5) Intact bacteria may breach the epithelial barrier and be phagocytosed by monocytes or neutrophils. Failure to mount an effective oxidative burst in phagocytic cells then allows dissemination of bacteria through the circulation. </p><div class="sb-div caption-clear"></div></div></div>"><img class="fragment-image" src="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F1.medium.jpg" alt="Fig 1"/></a></div></div><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="fig-caption"><span class="fig-label">Fig 1</span> <p id="p-13" class="first-child">Microbial dysbiosis in the intestine. (1) Alcohol is converted to acetaldehyde in intestinal epithelial cells. Acetaldehyde induces cellular damage, including proteins that maintain tight junctions between epithelial cells, leading to loss of mucosal integrity. (2) Multiple changes in the composition of the intestinal microbiome are observed in patients with alcohol-related liver disease and alcohol-related hepatitis. (3) Dysbiosis of the microbiome leads to further damage to the epithelial barrier and loss of mucosal integrity. (4) Bacterial products, including lipopolysaccharides and toxins such as the <em>Enterococcus faecalis</em> cytolysin toxin cross the damaged epithelium into the mesenchymal blood vessels and subsequently reach the liver via the portal venous system. (5) Intact bacteria may breach the epithelial barrier and be phagocytosed by monocytes or neutrophils. Failure to mount an effective oxidative burst in phagocytic cells then allows dissemination of bacteria through the circulation. </p><div class="sb-div caption-clear"></div></div><ul class="highwire-figure-links list-inline"><li class="download-fig first"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 1">Download figure</a></li> <li class="new-tab"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank">Open in new tab</a></li> <li class="download-ppt last"><a href="/highwire/powerpoint/1090002" class="highwire-figure-link highwire-figure-link-ppt">Download powerpoint</a></li> </ul></div></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"></div></div><p id="p-14">Heavy alcohol consumption is associated with numerous changes in the composition of the intestinal microbiome.<a id="xref-ref-28-1" class="xref-bibr" href="#ref-28">28</a> Although the biological significance of these changes is not fully understood, there are several lines of evidence which implicate this dysbiosis in the pathogenesis of ALD. If the fecal microbiome of patients with AH is transferred into a mouse model of ALD then the severity of liver steatosis and inflammation are significantly worse than the fecal microbiome from healthy individuals.<a id="xref-ref-29-1" class="xref-bibr" href="#ref-29">29</a> This seems to indicate that the microbiome itself is pathogenic. A study by Duan and colleagues demonstrated that the prevalence of <em>Enterococcus faecalis</em> in fecal samples from patients with ALD, and particularly those with AH, is much higher than in healthy populations.<a id="xref-ref-30-1" class="xref-bibr" href="#ref-30">30</a> Furthermore, a proportion of <em>E faecalis</em> bacteria encode a secreted cytolysin protein which is toxic to hepatocytes; carriage of the cytolysin-producing <em>E faecalis</em> was associated with higher mortality compared with patients with AH who did not carry this strain.<a id="xref-ref-30-2" class="xref-bibr" href="#ref-30">30</a></p><p id="p-15">Alcohol is directly toxic to the intestinal epithelium and causes a loss of mucosal integrity resulting in increased gut permeability.<a id="xref-ref-31-1" class="xref-bibr" href="#ref-31">31</a> Epithelial cells in the stomach and upper gastrointestinal tract metabolise alcohol to acetaldehyde, which may damage the cell, but lack the ability to convert this to relatively inert acetate. In addition to this biochemical toxicity, the abnormal microbiome is also thought to contribute to the breakdown in mucosal integrity, possibly through the production of proteolytic enzymes which damage intercellular tight junctions. Increased permeability allows the translocation of microbial products or possibly intact microbes into the portal venous system, from where they can reach the hepatic sinusoids. Interestingly, in the presence of an intact intestinal mucosa the <em>E faecalis</em> cytolysin does not seem to cause hepatotoxicity.</p><p id="p-16">Kupffer cells, a specialized tissue resident macrophage which lives in the hepatic sinusoids, respond to microbial products via pathogen-associated molecular pattern receptors. Primarily Kupffer cells respond to lipopolysaccharide from the bacterial cell wall through Toll-like receptor (TLR) 4. TLR-4 signaling stimulates the production of pro-inflammatory cytokines and chemokines including IL-1b, IL-6, IL-8, and TNFa.<a id="xref-ref-32-1" class="xref-bibr" href="#ref-32">32</a> This results in tissue inflammation, including the recruitment of monocytes and polymorphonuclear cells to the liver.</p></div><div id="sec-7" class="subsection"><h3>Oxidative stress and lipid metabolism (<a id="xref-fig-2-1" class="xref-fig" href="#F2">fig 2</a>)</h3><div id="F2" class="fig pos-float type-figure odd"><div class="fig-inline"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F2.large.jpg?width=800&height=600" title="Effects of alcohol on the liver. (1) Alcohol metabolism results in the accumulation of lipids within hepatocytes due to excess calorie consumption, increased lipogenesis, and reduced lipid oxidation. (2) Generation of excess reactive oxygen species through the metabolism of alcohol in the cytochrome P450 system leads to widespread damage of intracellular organelles. The resulting ballooned hepatocytes are a histological hallmark of steatohepatitis. Increased senescent cells in the liver produce pro-inflammatory cytokines which activate stellate cells. (3) Lipopolysaccharide and other bacterial products in the portal venous blood interact with toll-like receptors on (4) macrophages (including Kupffer cells) in the hepatic sinusoids, resulting in the secretion of inflammatory cytokines and chemokines. (5) Chemokine secretion leads to infiltration of the hepatic parenchyma by inflammatory cells including lymphocytes and neutrophils. (6) Stellate cells, resident in the space of Disse between endothelial cells and parenchymal cells are activated by inflammatory signals transforming them into a myofibroblast phenotype. Activated stellate cells secrete collagen, resulting in fibrosis and eventually cirrhosis. (7) Inflammation and epigenetic changes in the hepatocytes leads to loss of cell identity (de-differentiation). Reduction in expression of multiple metabolic pathways, including bile acid transporters, is responsible for jaundice and liver failure." class="colorbox fragment-images colorbox-load" rel="gallery-fragment-images" data-figure-caption="<div class="highwire-markup"><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"></div></div>"><img class="fragment-image" src="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F2.medium.jpg" alt="Fig 2"/></a></div></div><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="fig-caption"><span class="fig-label">Fig 2</span> <p id="p-17" class="first-child">Effects of alcohol on the liver. (1) Alcohol metabolism results in the accumulation of lipids within hepatocytes due to excess calorie consumption, increased lipogenesis, and reduced lipid oxidation. (2) Generation of excess reactive oxygen species through the metabolism of alcohol in the cytochrome P450 system leads to widespread damage of intracellular organelles. The resulting ballooned hepatocytes are a histological hallmark of steatohepatitis. Increased senescent cells in the liver produce pro-inflammatory cytokines which activate stellate cells. (3) Lipopolysaccharide and other bacterial products in the portal venous blood interact with toll-like receptors on (4) macrophages (including Kupffer cells) in the hepatic sinusoids, resulting in the secretion of inflammatory cytokines and chemokines. (5) Chemokine secretion leads to infiltration of the hepatic parenchyma by inflammatory cells including lymphocytes and neutrophils. (6) Stellate cells, resident in the space of Disse between endothelial cells and parenchymal cells are activated by inflammatory signals transforming them into a myofibroblast phenotype. Activated stellate cells secrete collagen, resulting in fibrosis and eventually cirrhosis. (7) Inflammation and epigenetic changes in the hepatocytes leads to loss of cell identity (de-differentiation). Reduction in expression of multiple metabolic pathways, including bile acid transporters, is responsible for jaundice and liver failure.</p><div class="sb-div caption-clear"></div></div><ul class="highwire-figure-links list-inline"><li class="download-fig first"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F2.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Fig 2">Download figure</a></li> <li class="new-tab"><a href="https://www.bmj.com/content/bmj/383/bmj-2023-077090/F2.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank">Open in new tab</a></li> <li class="download-ppt last"><a href="/highwire/powerpoint/1089998" class="highwire-figure-link highwire-figure-link-ppt">Download powerpoint</a></li> </ul></div></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"></div></div><p id="p-18">Alcohol consumption results in several metabolic changes in the liver cells. At low concentrations alcohol is metabolized by alcohol dehydrogenase to acetaldehyde and by acetaldehyde dehydrogenase to acetate. Acetate is an energy source which can be used in the Krebs cycle but may also be used in lipogenesis. Heavy alcohol consumption is commonly a cause of obesity and liver steatosis due to the excess calorie consumption. Acetaldehyde may form adducts with proteins and other macromolecules within the cells, causing cell damage through loss of function and possibly stimulating autoimmune responses due to the creation of neoantigens. In excess, the acetaldehyde dehydrogenase pathway is fully saturated and alcohol is metabolised in the cytochrome P450 system via the enzyme CYP2E1.<a id="xref-ref-33-1" class="xref-bibr" href="#ref-33">33</a> This metabolic pathway generates an excess of reactive oxygen species resulting in damage to cell membranes, organelles, and macromolecules. This oxidative damage can be countered through oxidative defense systems, particularly through provision of glutathione. In patients who drink heavily, dietary habits may result in lower levels of glutathione and its precursors. Furthermore, in patients with cirrhosis the key glutathione generating enzyme, methionine adenosyl transferase 1, is expressed at markedly reduced levels, resulting in reduced capacity for oxidative defense.<a id="xref-ref-34-1" class="xref-bibr" href="#ref-34">34</a></p><p id="p-19">Lipid homeostasis is more widely deranged in patients with ALD, with overall increased lipogenesis and reduced lipid oxidation.<a id="xref-ref-35-1" class="xref-bibr" href="#ref-35">35</a> Ethanol metabolism increases the ratio of NADH:NAD within the cell, which inhibits β-oxidation of fatty acids. Alcohol exposure also increases the expression of the transcription factors SREBP-1c and ChREBP which regulate lipogenesis.<a id="xref-ref-36-1" class="xref-bibr" href="#ref-36">36</a><a id="xref-ref-37-1" class="xref-bibr" href="#ref-37">37</a> Excess lipid within the cell causes a stress response in the endoplasmic reticulum and mitochondrial damage. In addition to the intrinsic damage modulated by deranged lipid metabolism, steatotic hepatocytes seem to be more sensitive to external toxic signals, leading to apoptosis and other forms of cell death.<a id="xref-ref-35-2" class="xref-bibr" href="#ref-35">35</a> The importance of deranged lipid homeostasis in the pathogenesis of ALD is underlined by genetic associations in loci related to lipid metabolism, namely the genes <em>PNPLA3</em>, <em>TM6SF2</em>, <em>HSD17B13</em>, and <em>MBOAT7</em>.<a id="xref-ref-38-1" class="xref-bibr" href="#ref-38">38</a> The <em>PNPLA3</em> variant has reduced lipase activity, resulting in reduced secretion of very low density lipoprotein and excess accumulation of lipid within the cell.</p></div><div id="sec-8" class="subsection"><h3>Loss of hepatocyte differentiation and failure of regeneration</h3><p id="p-20">AH, the most severe form of ALD, presents with liver failure, characterized by low levels of clotting factors, albumin, and other serum proteins as well as high levels of bilirubin.<a id="xref-ref-39-1" class="xref-bibr" href="#ref-39">39</a> Not all patients with AH have cirrhosis, although advanced fibrosis is invariably present, suggesting that the features of liver failure cannot be fully explained by paucity of hepatocytes. Epigenetic modification of the hepatocyte nuclear factor 4 a (HNF4a) gene locus may provide a link between inflammation and loss of hepatocyte function.<a id="xref-ref-40-1" class="xref-bibr" href="#ref-40">40</a> HNF4a is a key transcription factor which up-regulates hepatocyte functions such as albumin production, gluconeogenesis, and bile acid transport. In AH it has been shown that a fetal isoform (P2) of HNF4a is produced in response to the cytokine transforming growth factor b (TGFb), which has the opposite effect to the normal P1 isoform, therefore suppressing hepatocyte differentiation and function. In addition, patients with ALD have a high proportion of hepatocytes expressing markers of cellular senescence indicating that they would not be able to respond to increasing hepatocyte demand through proliferation.<a id="xref-ref-41-1" class="xref-bibr" href="#ref-41">41</a> An alternative pathway of liver regeneration through the generation of hepatocytes from the pluripotential stem cell niche adjacent to the portal tracts is observed in patients with ALD and specifically AH. Histologically this process, characterized by bile ductular proliferation, is associated with a poor prognosis as the stem cells seem to be unable to differentiate into mature hepatocytes at a sufficient rate.<a id="xref-ref-42-1" class="xref-bibr" href="#ref-42">42</a></p></div></div><div class="section other5" id="sec-9"><h2 class="">Natural course of alcohol-related liver disease</h2><p id="p-21">The disease progression of ALD is well defined but displays considerable variability. A recent systematic review and meta-analysis of histological studies of ALD incorporated data from 37 studies representing around 7500 patients.<a id="xref-ref-2-2" class="xref-bibr" href="#ref-2">2</a> The study reported abnormal liver histopathology in approximately 85% of individuals reporting excessive alcohol consumption (≥60 g/day of ethanol for included studies). A quarter of biopsies demonstrated steatohepatitis, and over half showed fibrosis or cirrhosis. In the subgroup of studies reporting outcome data, the annualized rate of progression to cirrhosis was 8-10% in those with steatohepatitis or pre-cirrhotic fibrosis. Liver-related mortality is related to the presence of progressive liver disease on biopsy and correlates with fibrosis stage, at least in patients with compensated liver disease.<a id="xref-ref-2-3" class="xref-bibr" href="#ref-2">2</a><a id="xref-ref-43-1" class="xref-bibr" href="#ref-43">43</a><a id="xref-ref-44-1" class="xref-bibr" href="#ref-44">44</a> The importance of drinking behavior in determining disease progression cannot be overstated. Abstinence from alcohol is a fundamental determinant of liver-related mortality at almost all stages of disease.<a id="xref-ref-2-4" class="xref-bibr" href="#ref-2">2</a><a id="xref-ref-43-2" class="xref-bibr" href="#ref-43">43</a><a id="xref-ref-45-1" class="xref-bibr" href="#ref-45">45</a><a id="xref-ref-46-1" class="xref-bibr" href="#ref-46">46</a> A recent Swedish study reported that a histological diagnosis of ALD is associated with a dramatic increase in the risk of mortality compared with population controls (five year cumulative mortality 40.9% <em>v</em> 5.8%), particularly from liver-related events and within in the first year after diagnosis.<a id="xref-ref-47-1" class="xref-bibr" href="#ref-47">47</a> This finding may be attributed in part to the comparatively late stage of disease at diagnosis (52% prevalence of cirrhosis at baseline), but the increased risk of mortality was not confined to this group. In comparison with non-alcohol related fatty liver disease, ALD typically presents at a later stage, is more rapidly progressive, and is associated with greater mortality from liver-specific causes.<a id="xref-ref-48-1" class="xref-bibr" href="#ref-48">48</a><a id="xref-ref-49-1" class="xref-bibr" href="#ref-49">49</a> Estimates of the incidence of hepatocellular carcinoma in patients with ALD cirrhosis vary, though many studies report an annualised risk in the range 1.5-3%.<a id="xref-ref-50-1" class="xref-bibr" href="#ref-50">50</a><a id="xref-ref-51-1" class="xref-bibr" href="#ref-51">51</a><a id="xref-ref-52-1" class="xref-bibr" href="#ref-52">52</a><a id="xref-ref-53-1" class="xref-bibr" href="#ref-53">53</a></p><p id="p-22">Alcohol-related hepatitis is a less common presentation of ALD, with population level estimates of the annual incidence at 25-45 per 100 000 person years.<a id="xref-ref-54-1" class="xref-bibr" href="#ref-54">54</a><a id="xref-ref-55-1" class="xref-bibr" href="#ref-55">55</a> However, the severity of disease means AH may account for up to 20% of hospital admissions for ALD.<a id="xref-ref-56-1" class="xref-bibr" href="#ref-56">56</a> Affected individuals were typically men in their fifth sixth decade. However, several epidemiological studies in the US and Europe indicate a concerning rise in the incidence of AH in younger age groups and among women.<a id="xref-ref-54-2" class="xref-bibr" href="#ref-54">54</a><a id="xref-ref-56-2" class="xref-bibr" href="#ref-56">56</a><a id="xref-ref-57-1" class="xref-bibr" href="#ref-57">57</a> Mortality from AH is high and tightly linked to the degree of liver dysfunction at presentation. Severe AH (defined by Maddrey’s discriminant function (MDF) >32, model for end-stage liver disease (MELD) >18, or Glasgow alcoholic hepatitis score (GAHS) >8) confers a high risk of short term mortality which nears 30% at 90 days<a id="xref-ref-58-1" class="xref-bibr" href="#ref-58">58</a><a id="xref-ref-59-1" class="xref-bibr" href="#ref-59">59</a> and has changed little in the 50 years since the condition was first described.<a id="xref-ref-60-1" class="xref-bibr" href="#ref-60">60</a> Non-severe AH (MDF <32) is not, however, benign and confers a substantial mortality risk of around 20% at one year.<a id="xref-ref-46-2" class="xref-bibr" href="#ref-46">46</a></p><p id="p-23">Variability in disease development and progression is, in part, genetically determined. Large scale genome-wide association studies have identified several loci associated with ALD disease risk, many of which are associated with lipid metabolism. These include <em>PNPLA3</em>, <em>TM6SF2</em>, <em>HSD17B13</em>, <em>MBOAT7</em>, <em>MARC1</em>, and <em>SERPINA1</em>, all of which show similar associations with non-alcohol related fatty liver disease.<a id="xref-ref-61-1" class="xref-bibr" href="#ref-61">61</a><a id="xref-ref-62-1" class="xref-bibr" href="#ref-62">62</a><a id="xref-ref-63-1" class="xref-bibr" href="#ref-63">63</a> Genetic studies also indicate certain loci also influence disease progression and the development of complications. The variant rs738409 in <em>PNPLA3</em> has been associated with age of onset, disease progression, and survival even in patients with established cirrhosis.<a id="xref-ref-64-1" class="xref-bibr" href="#ref-64">64</a><a id="xref-ref-65-1" class="xref-bibr" href="#ref-65">65</a><a id="xref-ref-66-1" class="xref-bibr" href="#ref-66">66</a><a id="xref-ref-67-1" class="xref-bibr" href="#ref-67">67</a><a id="xref-ref-68-1" class="xref-bibr" href="#ref-68">68</a> Variants in <em>PNPLA3</em>, <em>TM6SF2</em>, <em>HSD17B13</em>, <em>TERT</em>, and <em>WNT3A-WNT9A</em> are associated with the risk of hepatocellular carcinoma.<a id="xref-ref-69-1" class="xref-bibr" href="#ref-69">69</a><a id="xref-ref-70-1" class="xref-bibr" href="#ref-70">70</a></p></div><div class="section other6" id="sec-10"><h2 class="">Screening for alcohol-related liver disease</h2><p id="p-24">The large proportion of patients with ALD who present with advanced disease coupled with high mortality in the period immediately after diagnosis<a id="xref-ref-47-2" class="xref-bibr" href="#ref-47">47</a> underscore the need to identify patients at earlier disease stages. If abstinence can be achieved then disease progression will likely be halted or even reversed, with positive impact on clinical outcomes.<a id="xref-ref-2-5" class="xref-bibr" href="#ref-2">2</a><a id="xref-ref-43-3" class="xref-bibr" href="#ref-43">43</a><a id="xref-ref-44-2" class="xref-bibr" href="#ref-44">44</a> ALD cirrhosis develops over years of heavy drinking during which affected individuals may have multiple healthcare contacts, each representing a missed opportunity to intervene.<a id="xref-ref-71-1" class="xref-bibr" href="#ref-71">71</a><a id="xref-ref-72-1" class="xref-bibr" href="#ref-72">72</a> Of patients with healthcare attendances due to alcohol related issues, 7-16% will develop cirrhosis in the next 8-12 years.<a id="xref-ref-73-1" class="xref-bibr" href="#ref-73">73</a><a id="xref-ref-74-1" class="xref-bibr" href="#ref-74">74</a> Multiple hospital contacts with alcohol-related issues defines a population at further increased risk.<a id="xref-ref-74-2" class="xref-bibr" href="#ref-74">74</a> Screening need not be confined to the healthcare setting, workplace-based studies have demonstrated a substantial case acquisition rate.<a id="xref-ref-75-1" class="xref-bibr" href="#ref-75">75</a></p></div><div class="section other7" id="sec-11"><h2 class="">Non-invasive tests for diagnosis and staging of alcohol-related liver disease</h2><p id="p-25">The gold standard for the diagnosis and staging of ALD is liver biopsy. However, as an invasive test requiring specialist training and conferring a risk of morbidity, it is neither practical nor appropriate to perform in all patients with suspected ALD and is rarely undertaken in clinical practice.<a id="xref-ref-44-3" class="xref-bibr" href="#ref-44">44</a><a id="xref-ref-76-1" class="xref-bibr" href="#ref-76">76</a><a id="xref-ref-77-1" class="xref-bibr" href="#ref-77">77</a> In most clinical scenarios the pertinent questions are the extent of fibrosis and the presence or absence of cirrhosis as these features identify those patients with progressive disease and at greatest risk of adverse liver-related outcomes.<a id="xref-ref-77-2" class="xref-bibr" href="#ref-77">77</a></p><p id="p-26">In patients with established or decompensated chronic liver disease, clinical stigmata, potentially in conjunction with biochemical and radiological features, may be sufficient to establish a diagnosis of cirrhosis. Establishing the degree of fibrosis at earlier stages of disease is more challenging. Liver ultrasound demonstrates acceptable specificity in identifying steatosis, with sensitivity proportional to the severity of steatosis.<a id="xref-ref-78-1" class="xref-bibr" href="#ref-78">78</a> Although many clinicians factor the presence of imaging features suggestive of cirrhosis into their diagnostic algorithm, there are limited data regarding the diagnostic performance of ultrasound for ALD cirrhosis.<a id="xref-ref-79-1" class="xref-bibr" href="#ref-79">79</a> Other tests to detect and estimate the degree of underlying fibrosis in ALD may be derived as composite scores from commonly measured biochemical tests (namely, the aspartate aminotransferase to platelet ratio index (APRI) and the fibrosis-4 (FIB4) index), proprietary tests of panels of fibrosis biomarkers (enhanced liver fibrosis (ELF) test, FibroTest), or based on measurement of liver stiffness using elastography (Fibroscan, shear wave elastography, magnetic resonance elastography, acoustic radiation force impulse imaging). Serum-based tests lend themselves to larger scale deployment as the need for specialist equipment and training presents challenges to widespread deployment of elastography-based techniques. The diagnostic performance of ELF and FibroTest for ALD cirrhosis is good (area under the receiver operated characteristic (AUROC) >0.8) and superior to that of indirect indices of liver fibrosis derived from routine biochemical tests.<a id="xref-ref-80-1" class="xref-bibr" href="#ref-80">80</a><a id="xref-ref-81-1" class="xref-bibr" href="#ref-81">81</a> A cut-off of 10.5 for ELF has been reported as having a high negative predictive value in a population of patients where the anticipated prevalence of advanced fibrosis is low, indicating its utility as a screening test.<a id="xref-ref-80-2" class="xref-bibr" href="#ref-80">80</a></p><p id="p-27">Several studies have evaluated the utility of liver stiffness measurement (LSM) by transient elastography for diagnosis of ALD fibrosis and cirrhosis. Individual studies and meta-analyses indicate good diagnostic performance, particularly when applied to rule out cirrhosis or advanced fibrosis.<a id="xref-ref-80-3" class="xref-bibr" href="#ref-80">80</a><a id="xref-ref-82-1" class="xref-bibr" href="#ref-82">82</a><a id="xref-ref-83-1" class="xref-bibr" href="#ref-83">83</a><a id="xref-ref-84-1" class="xref-bibr" href="#ref-84">84</a> The optimal LSM cut-off to diagnose significant ALD is unclear, but values in the range 12-15 kPa appear to predict advanced fibrosis or cirrhosis (≥F3) with good sensitivity and reasonable specificity.<a id="xref-ref-83-2" class="xref-bibr" href="#ref-83">83</a><a id="xref-ref-84-2" class="xref-bibr" href="#ref-84">84</a> There is etiology-specific variation in the LSM values that predict significant liver disease, and those for ALD are generally higher than those for other liver diseases.<a id="xref-ref-85-1" class="xref-bibr" href="#ref-85">85</a> LSM may be affected by factors independent of the degree of underlying fibrosis: these include hepatic congestion, cholestasis, alcohol, recency of food intake, and hepatic inflammation. Accordingly, steatohepatitis on biopsy and higher serum levels of aspartate aminotransferase (AST) and bilirubin have all been associated with higher LSM values and the need to use higher cut-off values for any given degree of fibrosis.<a id="xref-ref-84-3" class="xref-bibr" href="#ref-84">84</a> LSM falls with detoxification from alcohol, with the degree of fall linked to the serum AST. Repetition of LSM after at least two weeks of abstinence may allow patients to be more accurately classified.<a id="xref-ref-82-2" class="xref-bibr" href="#ref-82">82</a><a id="xref-ref-86-1" class="xref-bibr" href="#ref-86">86</a></p><p id="p-28">Modeling suggests that screening for ALD fibrosis using non-invasive tests is cost-effective in populations with excess alcohol consumption under a variety of different test combinations and assumptions regarding ability to affect drinking behavior.<a id="xref-ref-87-1" class="xref-bibr" href="#ref-87">87</a> A recent study demonstrated the feasibility of screening for ALD and non-alcoholic fatty liver disease using non-invasive tests in the general population in Denmark.<a id="xref-ref-88-1" class="xref-bibr" href="#ref-88">88</a> However, it is likely that consistent and widespread implementation of this form of screening will be challenging. A recently reported artificial intelligence-based model demonstrated significantly better performance in predicting significant liver disease in at-risk individuals in a primary care population than models based on blood-based indices.<a id="xref-ref-89-1" class="xref-bibr" href="#ref-89">89</a> Combined with the digitisation of healthcare records, this raises the exciting prospect of integrating screening models into clinical systems.</p></div><div class="section other8" id="sec-12"><h2 class="">Risk stratification in alcohol-related liver disease using non-invasive tests</h2><p id="p-29">Increasing literature exists about the prognostic information offered by many of these non-invasive tests in ALD. FIB-4, ELF and Fibroscan have all been associated with adverse liver-related events (<em>viz</em>. mortality, development of variceal hemorrhage, ascites or hepatocellular carcinoma) though typically with moderate prognostic performance.<a id="xref-ref-81-2" class="xref-bibr" href="#ref-81">81</a><a id="xref-ref-90-1" class="xref-bibr" href="#ref-90">90</a> Nonetheless it appears that LSM >15k Pa or ELF >10.5 define populations of patient with ALD at dramatically increased risk of disease complications.<a id="xref-ref-91-1" class="xref-bibr" href="#ref-91">91</a> The development of clinically significant portal hypertension is associated with an increased risk of adverse liver related events including variceal hemorrhage and portends a poor prognosis. The Baveno VI consensus guidelines indicated that patients with LSM <20 kPa and a platelet count >150×10<sup>9</sup>/L had a low probability of having varices requiring therapy.<a id="xref-ref-92-1" class="xref-bibr" href="#ref-92">92</a> Studies examining the performance of these criteria have reported a high negative predictive value in patient populations including those with ALD indicating their prognostic value in this setting.<a id="xref-ref-93-1" class="xref-bibr" href="#ref-93">93</a><a id="xref-ref-94-1" class="xref-bibr" href="#ref-94">94</a> These thresholds were restated in Baveno VII and expanded with recommendations that LSM >25 kPa was sufficient to rule in clinically significant portal hypertension and identify a population of patients with ALD cirrhosis likely to have endoscopic evidence of portal hypertension and an increased risk of decompensation.<a id="xref-ref-95-1" class="xref-bibr" href="#ref-95">95</a> A recent study established a series of serum protein panels which were able to predict liver biopsy features and subsequent clinical events in patients with ALD with a greater accuracy than existing non-invasive tools.<a id="xref-ref-96-1" class="xref-bibr" href="#ref-96">96</a> Subject to validation these panels may form the basis of non-invasive panels offering greater diagnostic and prognostic information and the opportunity to study earlier stages of ALD before the development of cirrhosis.</p></div><div class="section other9" id="sec-13"><h2 class="">Definition and classification of alcohol use disorder</h2><p id="p-30">In ICD-11, harmful use of alcohol is diagnosed when alcohol consumption has caused damage to a person’s physical or mental health or has resulted in behavior leading to harm to the health of others.<a id="xref-ref-97-1" class="xref-bibr" href="#ref-97">97</a> Alcohol dependence is a complex syndrome that includes “impaired control over their alcohol use” as a key feature which may not necessarily be accompanied by craving. Other features are alcohol use taking precedence over other activities and physiological neuroadaptations—tolerance and withdrawal. “Binge” is a term widely used, but definitions differ across the world. In the UK, binge drinking is drinking six or more units of alcohol for a woman and eight or more units for a man in a single session. If conveying an “on-off” pattern, bingeing may mean the individual is alcohol dependent as they cannot control their consumption when they start drinking. While previously ICD and DSM diagnostic categories were similar, DSM-5 is now different to ICD-11 with alcohol use disorder seen as a continuum from mild (harmful) to severe (dependent) rather than distinct entities as in ICD-11.<a id="xref-ref-97-2" class="xref-bibr" href="#ref-97">97</a><a id="xref-ref-98-1" class="xref-bibr" href="#ref-98">98</a> As many people who drink excessively have comorbid psychiatric and physical disorders, including other substance misuse, these must also be assessed and managed alongside their alcohol problems. Any safeguarding concerns such as domestic violence or risk to minors should also be explored.</p></div><div class="section other10" id="sec-14"><h2 class="">Neurobiology in alcohol use disorders</h2><p id="p-31">Characterizing the neurobiology of alcohol use disorder informs optimization of current methodology and development of new approaches to prevent and treat addiction. The pleasurable effects of alcohol are mediated by increasing endorphins and dopamine levels in the brain in the so called pleasure-reward dopaminergic mesolimbic system.<a id="xref-ref-99-1" class="xref-bibr" href="#ref-99">99</a><a id="xref-ref-100-1" class="xref-bibr" href="#ref-100">100</a> As alcohol consumption becomes more chronic, neuroadaptations occur. Blunted function in μ-opioid receptor and in dopaminergic systems are present in alcohol dependence and may also be implicated in vulnerability to addiction.<a id="xref-ref-101-1" class="xref-bibr" href="#ref-101">101</a><a id="xref-ref-102-1" class="xref-bibr" href="#ref-102">102</a><a id="xref-ref-103-1" class="xref-bibr" href="#ref-103">103</a> Chronic alcohol consumption also results in increased activity of the κ-opioid receptor and dynorphin system, which is associated with dysphoria to counter the pleasure from endorphin-stimulated μ-opioid receptor system.<a id="xref-ref-100-2" class="xref-bibr" href="#ref-100">100</a></p><p id="p-32">In alcohol dependence, blunted activity is seen in the striatum of the mesolimbic system in response to non-salient rewards such as money, but, notably, heightened activity is seen in response to salient (ie, alcohol) cues.<a id="xref-ref-104-1" class="xref-bibr" href="#ref-104">104</a><a id="xref-ref-105-1" class="xref-bibr" href="#ref-105">105</a><a id="xref-ref-106-1" class="xref-bibr" href="#ref-106">106</a><a id="xref-ref-107-1" class="xref-bibr" href="#ref-107">107</a> Treatment, whether pharmacological (such as naltrexone) or psychological, has been shown to attenuate this hyper-reactivity to alcohol cues.<a id="xref-ref-107-2" class="xref-bibr" href="#ref-107">107</a><a id="xref-ref-108-1" class="xref-bibr" href="#ref-108">108</a> Decreased function in prefrontal cortical areas contribute to difficulties in, for example, decision making, response inhibition, error monitoring, and salience attribution that are commonly seen in addiction.<a id="xref-ref-100-3" class="xref-bibr" href="#ref-100">100</a> Many neuroimaging studies have also shown dysregulated function in prefrontal cortical regions in response to cues and craving.<a id="xref-ref-104-2" class="xref-bibr" href="#ref-104">104</a><a id="xref-ref-107-3" class="xref-bibr" href="#ref-107">107</a></p><p id="p-33">Many people drink alcohol for its anxiolytic and sedative effects. These effects are primarily mediated by the brain’s inhibitory GABA-benzodiazepine system.<a id="xref-ref-99-2" class="xref-bibr" href="#ref-99">99</a> Alcohol acutely boosts activity of the GABA-benzodiazepine receptor and acutely antagonises the brain’s main excitatory glutamatergic system, particularly the NMDA receptor, resulting in reducing brain activity. Regular consumption of alcohol results in tolerance because of reduced sensitivity of the GABA-benzodiazepine receptor and an up-regulation of NMDA glutamate receptors. This greater number of NMDA glutamate receptors is thought to underpin amnesia during drinking episodes. These neuroadaptations associated with tolerance also drive withdrawal symptomatology in the absence of alcohol. Such symptoms include tremor, sweating, and anxiety as well as potentially life-threatening complications such as seizures and delirium tremens. The amygdala and associated neurotransmitters (such as dynorphin, noradrenaline, and substance P/NK1) play a key role in mediating many of aspects of withdrawal such as negative mood and heightened stress responses.<a id="xref-ref-109-1" class="xref-bibr" href="#ref-109">109</a></p><p id="p-34">Brain atrophy, commonly seen with chronic alcohol consumption, likely results from hyperglutamatergic activity and neuroinflammation.<a id="xref-ref-110-1" class="xref-bibr" href="#ref-110">110</a><a id="xref-ref-111-1" class="xref-bibr" href="#ref-111">111</a> It is important to recognize and inform your patient that functional and structural recovery occurs with abstinence, particularly in the frontal cortex.<a id="xref-ref-112-1" class="xref-bibr" href="#ref-112">112</a><a id="xref-ref-113-1" class="xref-bibr" href="#ref-113">113</a></p></div><div class="section other11" id="sec-15"><h2 class="">Treatment of alcohol use disorder</h2><p id="p-35">If an individual has ALD, abstinence from alcohol will facilitate recovery, and they should be given information about local addiction services. It is important to determine if someone is alcohol dependent and if they have had previous complications during withdrawal, such as a seizure or delirium tremens. If they have, they will need medical support (see below) to safely stop drinking and may need to be admitted as an inpatient if they previously experienced complications, are unwell, or their home environment is not supportive. Although withdrawal from alcohol may be routinely managed by hepatology teams, any patient should also be referred to an addiction service to ensure that appropriate levels of support and treatment are offered to achieve and maintain abstinence.</p><div id="sec-16" class="subsection"><h3>Psychosocial interventions, self help, and peer support</h3><p id="p-36">A range of approaches have been shown to be effective in reducing unhealthy consumption of alcohol and in those with chronic liver disease.<a id="xref-ref-114-1" class="xref-bibr" href="#ref-114">114</a> In someone who is drinking at a harmful level, a brief intervention based on the acronym FRAMES is appropriate (Feedback (on the risk from their damaged liver etc), Responsibility, Advice, Menu, Empathy, Self efficacy).<a id="xref-ref-114-2" class="xref-bibr" href="#ref-114">114</a><a id="xref-ref-115-1" class="xref-bibr" href="#ref-115">115</a><a id="xref-ref-116-1" class="xref-bibr" href="#ref-116">116</a> Completing a drink diary (when, how much, why) is also effective in allowing the patient and practitioner to understand drinking behaviors and how to potentially modify them.</p><p id="p-37">Motivational interviewing can be used to support changes in behavior through bringing to the fore and resolving discrepancies between the patient’s goals and actions, as well as any ambivalence. A cognitive behavioral approach aims to identify core beliefs or underlying assumptions that can be seen as irrational and resulting in a dysfunctional relationship with alcohol. The individual is given homework between sessions, which are of limited number. Cognitive behavior therapy is also widely used to treat depression and anxiety, both of which are highly comorbid with alcohol use disorder. Relapse prevention involves training the patient to identify high risk situations and develop coping skills and alternative strategies to drinking. Contingency management is based on using positive reinforcement, such as vouchers for maintaining abstinence, to change behavior. </p><p id="p-38">Other approaches include social behavior and network therapy, which aims to develop supportive non-alcohol social networks or couples or family therapy to facilitate change within close relationships. Many patients have experienced trauma in their life, and increasingly any planned treatment is now conceptualized as “trauma-informed” to take account of this. In addition to individual work, complementary group work is generally offered. Because of the covid-19 pandemic, services now may deliver treatment and support online rather than in person. A mix of these different psychosocial approaches are used clinically rather than rigidly sticking to one model. A systematic review of 13 observational studies and RCTs of 1945 patients with chronic liver disease explored the impact of integrated combination psychotherapy with cognitive behavior therapy, motivational enhancement therapy (MET), and comprehensive medical care. Regarding induction of abstinence, more patients reported abstinence in four RCTs from the intervention (45.4%, range 25.4-74%) than control groups (36.7%, range 19.7-50%), with observational studies also indicating benefit. Regarding maintenance of abstinence, the only RCT reported MET was non-significantly superior (84.8% <em>v</em> 93.4%) with one observational study showing benefit of intervention on relapse compared with control (16.4% <em>v</em> 35.1%).<a id="xref-ref-117-1" class="xref-bibr" href="#ref-117">117</a></p><p id="p-39">For those who are dependent on alcohol, peer support organisations such as 12-step Alcoholics Anonymous (<a href="https://www.alcoholics-anonymous.org.uk/">https://www.alcoholics-anonymous.org.uk/</a>) and SMART recovery (<a href="https://smartrecovery.org.uk/">https://smartrecovery.org.uk/</a>) play a valuable role in recovery, particularly in providing advice and a non-alcohol network of support and friendship to those who may be isolated.<a id="xref-ref-118-1" class="xref-bibr" href="#ref-118">118</a> Meetings are widely available, some of which cater for particular groups (women only, LGBT) and can be accessed in person or online. In addition, organisations such as Al-Anon (<a href="https://www.al-anonuk.org.uk/">https://www.al-anonuk.org.uk/</a>), Al-Ateen (<a href="https://www.al-anonuk.org.uk/alateen/">https://www.al-anonuk.org.uk/alateen/</a>), or NACOA (<a href="https://nacoa.org.uk/">https://nacoa.org.uk/</a>) provide support for friends and relatives, including children, of someone with alcohol dependence.</p></div><div id="sec-17" class="subsection"><h3>Pharmacotherapy</h3><p id="p-40">Medication plays a key role in managing withdrawal and relapse prevention in moderate to severe alcohol dependence alongside psychosocial interventions.<a id="xref-ref-114-3" class="xref-bibr" href="#ref-114">114</a><a id="xref-ref-119-1" class="xref-bibr" href="#ref-119">119</a> There is very limited evidence to support the use of medication in reducing harmful non-dependent drinking, and it is not generally recommended.<a id="xref-ref-114-4" class="xref-bibr" href="#ref-114">114</a></p><div id="sec-18" class="subsection"><h4>Detoxification</h4><p id="p-41">Alcohol withdrawal is potentially life threatening, and people who are alcohol dependent commonly require medication such as a reducing regimen of a benzodiazepine to prevent these complications.<a id="xref-ref-114-5" class="xref-bibr" href="#ref-114">114</a><a id="xref-ref-120-1" class="xref-bibr" href="#ref-120">120</a> In those with hepatic impairment, consideration can be given to using lorazepam or oxazepam due to their pharmacokinetics. Although anticonvulsants such as carbamazepine have been used in some countries for alcohol detoxification, their use is not widespread in the UK.<a id="xref-ref-119-2" class="xref-bibr" href="#ref-119">119</a></p></div><div id="sec-19" class="subsection"><h4>Preventing complications: thiamine</h4><p id="p-42">Thiamine is an essential cofactor for enzymes involved in brain metabolism of glucose, and in its absence anaerobic metabolism ensues, resulting in brain damage. Thiamine deficiency can be manifest as a range of signs and symptoms, but at its most serious, Wernicke’s encephalopathy, it is a medical emergency. The triad of ophthalmoplegia (nystagmus on lateral gaze), ataxia, and confusion are present in only about 10% of cases so a high index of suspicion is needed. It has been proposed that presence of any two of the criteria are sufficient for diagnosis.<a id="xref-ref-121-1" class="xref-bibr" href="#ref-121">121</a> Treatment of thiamine deficiency is with the parenteral thiamine preparation Pabrinex until no improvement is seen.<a id="xref-ref-119-3" class="xref-bibr" href="#ref-119">119</a> Everyone should be assessed for risk of thiamine deficiency—for example, poor nutrition or signs suggestive of deficiency (such as peripheral neuropathy)—so that they can receive Pabrinex.<a id="xref-ref-119-4" class="xref-bibr" href="#ref-119">119</a> It must be remembered that thiamine deficiency is not only seen during alcohol withdrawal and may occur with another condition increasing metabolic demands, such as infection. Therefore, any change in an individual’s condition such as increase in confusion or ataxia should prompt assessment of potential thiamine deficiency. Parenteral thiamine must be used if someone is thiamine deficient or at risk of deficiency, absorption of oral thiamine through the gut and transport into the brain is insufficient to replenish stores.<a id="xref-ref-122-1" class="xref-bibr" href="#ref-122">122</a> For all other patients with alcohol use disorder undergoing detoxification, oral thiamine can be used.<a id="xref-ref-119-5" class="xref-bibr" href="#ref-119">119</a></p></div><div id="sec-20" class="subsection"><h4>Relapse prevention</h4><p id="p-43">As an adjunct to psychosocial interventions, medication for relapse prevention should be considered for everyone with moderate to severe alcohol dependence. Based on extensive evidence from RCTs, the National Institute for Health and Care Excellence (NICE) recommends the NMDA receptor modulator (glutamate modulator) acamprosate or the non-selective opiate antagonist naltrexone as first line to support abstinence and to start when abstinent.<a id="xref-ref-114-6" class="xref-bibr" href="#ref-114">114</a> Meta-analyses of clinical trials suggest that acamprosate compared with placebo is efficacious in supporting abstinence (RR = 0.83 (95% CI 0.77 to 0.88)), while naltrexone prevents a lapse becoming a full-blown relapse (RR = 0.83 (0.75 to 0.91)).<a id="xref-ref-119-6" class="xref-bibr" href="#ref-119">119</a> Disulfiram, an aldehyde dehydrogenase inhibitor, was suggested by NICE as a second line treatment to support abstinence because of its potential adverse effects if combined with alcohol and the range of conditions in which it is absolutely or relatively contraindicated. In the UK, baclofen, a GABA-B agonist, is used off-label based on some evidence showing efficacy in supporting abstinence, particularly among those who are more severely dependent and anxious and have not responded licensed medications, although not all meta-analyses have found baclofen superior to placebo.<a id="xref-ref-123-1" class="xref-bibr" href="#ref-123">123</a><a id="xref-ref-124-1" class="xref-bibr" href="#ref-124">124</a><a id="xref-ref-125-1" class="xref-bibr" href="#ref-125">125</a><a id="xref-ref-126-1" class="xref-bibr" href="#ref-126">126</a><a id="xref-ref-127-1" class="xref-bibr" href="#ref-127">127</a> Other medications such as topiramate or gabapentin have been recommended as second line in the US but are not widely used or recommended in the UK.<a id="xref-ref-128-1" class="xref-bibr" href="#ref-128">128</a></p><p id="p-44">All the above relapse prevention medications are started once the person is abstinent and are to be taken every day. In contrast, nalmefene is licensed to start while a person is still drinking and “as needed.” Nalmefene is another opiate antagonist with slightly different pharmacology to naltrexone as it is a partial agonist at κ-opioid receptors rather than an antagonist. Nalmefene is licensed for use in alcohol dependence to support reduction in drinking in those who do not need immediate detoxification and whose drinking has not changed with psychosocial interventions. Combinations of relapse prevention medications can be used, but there is little evidence to guide which work best.</p><p id="p-45">All of these relapse prevention medications have been used in patients with abnormal liver function tests, and improvement is generally reported in clinical trials, but careful consideration is required if they are to be used for patients with severe hepatic impairment, and SmPCs (summaries of product characteristics), reviews, and guidelines should be consulted.<a id="xref-ref-114-7" class="xref-bibr" href="#ref-114">114</a><a id="xref-ref-119-7" class="xref-bibr" href="#ref-119">119</a><a id="xref-ref-123-2" class="xref-bibr" href="#ref-123">123</a><a id="xref-ref-129-1" class="xref-bibr" href="#ref-129">129</a> Because of the risk of hepatotoxicity, disulfiram and naltrexone should not be used in severe or acute hepatic impairment, acute hepatitis, or hepatic failure. On the other hand, trials of baclofen have been conducted safely in those with cirrhosis.<a id="xref-ref-130-1" class="xref-bibr" href="#ref-130">130</a></p><p id="p-46">It is notable, however, that increasingly fewer people are offered relapse prevention medication or continue beyond a few weeks of taking the medication despite their effectiveness in improving outcomes in those with liver disease.<a id="xref-ref-131-1" class="xref-bibr" href="#ref-131">131</a><a id="xref-ref-132-1" class="xref-bibr" href="#ref-132">132</a><a id="xref-ref-133-1" class="xref-bibr" href="#ref-133">133</a> Barriers to overcome include lack of knowledge of and confidence in the evidence base, concerns about cost, and philosophical views about “medicalizing” addiction and not using medication.<a id="xref-ref-134-1" class="xref-bibr" href="#ref-134">134</a></p></div></div></div><div class="section other12" id="sec-21"><h2 class="">Integration of hepatology and addiction services in secondary or primary care</h2><p id="p-47">To ensure optimal likelihood of recovery, people with ALD need to be supported to achieve abstinence from alcohol and to maintain it. This is best achieved via integrated cooperation of hepatology, addiction services, and general practice.<a id="xref-ref-135-1" class="xref-bibr" href="#ref-135">135</a><a id="xref-ref-136-1" class="xref-bibr" href="#ref-136">136</a> Despite this, such integration is rarely evident, with both patient-related and clinician-related barriers including stigma in patients and clinicians.<a id="xref-ref-137-1" class="xref-bibr" href="#ref-137">137</a> In parts of the UK, addiction services are now led by the third sector and outside the NHS, whereas hepatology services are within the NHS. This has had an immense impact on working together. For instance, staff in NHS and third sector involved in treatment of an individual may be able to communicate only with explicit patient consent, which might not be given.</p><p id="p-48">Many general hospitals have “alcohol care teams” which provide valuable expertise, assistance, and links with primary care and other community-based teams during any inpatient stays in a general hospital.<a id="xref-ref-138-1" class="xref-bibr" href="#ref-138">138</a> A joint outpatient clinic with hepatology and addiction services is a useful model to deliver and coordinate care, particularly for those patients reluctant to attend a community-based addiction service. Similarly, an alcohol specialist embedded in primary care, working alongside other professionals, can result in a more coordinated delivery of care.<a id="xref-ref-139-1" class="xref-bibr" href="#ref-139">139</a> While many hepatologists and GPs are comfortable prescribing medication for detoxification and relapse prevention, not all feel adequately skilled, so most of the prescribing is initiated in an addiction service. The patient’s GP is generally requested by community addiction services to organize any blood tests and physical investigations as required.</p><p id="p-49">In the UK, most dedicated inpatient units have closed, resulting in waiting lists of several weeks; this means that treatment for alcohol dependence, even complex cases, is largely community based. Because of changes in how addiction services are delivered in the UK, it is notable that most inpatient alcohol detoxifications now take place in non-specialist settings.<a id="xref-ref-140-1" class="xref-bibr" href="#ref-140">140</a> Similarly, relapse prevention treatment, such as psychosocial treatment, occurs primarily in the community. Assessment for residential rehabilitation can take many weeks, and, even when it is approved, waiting lists are long. Many community-based services offer a similar range of one-to-one and group sessions that someone may receive in a residential setting.</p><p id="p-50">As most addiction services rely on self referral, some patients may not go through with presenting to a local service despite expressing a willingness to seek treatment to their hepatologist or GP. Having an alcohol specialist in the hospital or primary care can provide greater support to increase the likelihood that the patient engages with addiction treatment. While addiction services will include input from psychiatry, psychology, and mental health nurses, assessment and treatment of any substantial psychiatric disorder will need referral to a mental health service. For some patients, a regular multi-professional meeting may be required to ensure all mental and physical health and social care needs are being optimally met along with management of any risks.</p></div><div class="section other13" id="sec-22"><h2 class="">Treatment of alcohol-related liver disease</h2><p id="p-51">At all stages of ALD, the key therapeutic intervention is to achieve alcohol abstinence. Even at the stage of decompensated cirrhosis, the withdrawal of alcohol makes a substantial impact on patient survival (see above). Unlike those at other stages of disease, patients with AH may continue to deteriorate and experience high mortality for up to 90 days after presentation despite cessation of alcohol. Urgent treatment is therefore required to treat AH specifically while not neglecting the need to support patients becoming abstinent after discharge from hospital.</p><p id="p-52">Despite the high prevalence of ALD cirrhosis, there have been remarkably few clinical trials of therapeutic interventions. The nature of the condition, variation in natural course in response to abstinence, and the complicated nature of patients’ lives when suffering with addiction undoubtedly make the conduct of clinical trials challenging. However, lack of investment by public and commercial funders also plays an important role. One randomized controlled trial, conducted over 20 years ago, randomized 123 patients with Childs-Pugh class A or B cirrhosis to treatment with the antioxidant S-adenosyl methionine (S-AME) or placebo. Overall there was a numerical mortality advantage (16% <em>v</em> 30%, P=0.077), but in patients in the Child-Pugh C class there was a significant mortality advantage (12% <em>v</em> 29%, P=0.025) for S-AME treatment.<a id="xref-ref-141-1" class="xref-bibr" href="#ref-141">141</a> Unfortunately, this study has never been repeated, although S-AME is available in many countries as an over-the-counter medication.</p><p id="p-53">A single double-blinded placebo-controlled trial evaluated the treatment of 68 patients (<em>v</em> 68 controls) with non-cirrhotic ALD using rifaximin to improve gut barrier function and reduce hepatic inflammation. The primary endpoint was improvement in histologically assessed liver fibrosis. While the primary endpoint was not achieved, the rate of fibrosis progression was reduced in the rifaximin treated group (0.42 (95% CI 0.18 to 0.98), P=0.044).<a id="xref-ref-142-1" class="xref-bibr" href="#ref-142">142</a></p><p id="p-54">AH is classified as severe when the Maddrey’s discriminant function, based on measurement of bilirubin and prothrombin time, is ≥32. The mortality for AH is around 20% at one month and 30% at three months.<a id="xref-ref-143-1" class="xref-bibr" href="#ref-143">143</a> The only treatment currently recommended is corticosteroids, such as prednisolone, with the aim of reducing inflammation in the liver.<a id="xref-ref-3-4" class="xref-bibr" href="#ref-3">3</a> In large trials and meta-analyses of 2111 patients, prednisolone treatment results in a small, short term survival advantage at one month (hazard ratio 0.64 (95% CI 0.48 to 0.86)) but no benefit at three months.<a id="xref-ref-59-2" class="xref-bibr" href="#ref-59">59</a><a id="xref-ref-144-1" class="xref-bibr" href="#ref-144">144</a> This loss of benefit is probably due to the increased rates of severe infections seen in patients treated with steroids.<a id="xref-ref-145-1" class="xref-bibr" href="#ref-145">145</a> However, subgroup analyses in patients who were enrolled in the STOPAH trial suggest that those with a neutrophil:lymphocyte ratio between 5 and 8 or those with a serum level of the cytokeratin 18 M30 fragment (CK18-M30) >5000 may derive a durable benefit from prednisolone treatment.<a id="xref-ref-146-1" class="xref-bibr" href="#ref-146">146</a><a id="xref-ref-147-1" class="xref-bibr" href="#ref-147">147</a></p><div id="sec-23" class="subsection"><h3>Transplantation</h3><p id="p-55">An orthotopic liver transplant is an option for patients with decompensated ALD cirrhosis and severe AH. Outcomes from transplantation for ALD cirrhosis are good, with one-year and five-year graft survival of 84% and 73% respectively.<a id="xref-ref-148-1" class="xref-bibr" href="#ref-148">148</a> Most patients with decompensated cirrhosis due to ALD will recompensate once they achieve alcohol abstinence, but approximately 10% will continue to deteriorate. Nevertheless, in the UK ALD is the most common indication for liver transplantation, representing 27% of all adult transplants in 2021-22 in the UK.<a id="xref-ref-11-2" class="xref-bibr" href="#ref-11">11</a> In many transplant centers a six-month abstinence rule is applied; this allows time for the effects of abstinence to be fully assessed, but, more controversially, this period of abstinence is thought to predict alcohol behavior after transplantation.<a id="xref-ref-149-1" class="xref-bibr" href="#ref-149">149</a> Selection for transplantation and priority for organ allocation is based on measures of residual liver function, commonly the Model for End Stage Liver Disease (MELD) based on creatinine, bilirubin, INR, and sodium. A MELD score of 20-29 indicates a mortality risk of 19.6% over three months and is a level at which transplantation may be considered.<a id="xref-ref-150-1" class="xref-bibr" href="#ref-150">150</a> In contrast to the US and much of the rest of Europe, the UK system employs a variant of the MELD score termed UKELD. A score greater than 49 is associated with a 9% one-year risk of mortality and represents the minimum criterion for listing.<a id="xref-ref-151-1" class="xref-bibr" href="#ref-151">151</a></p><p id="p-56">Disease recurrence after transplantation is a common and a widely accepted risk in most types of liver disease. However, in ALD the resumption of alcohol use after transplantation is often viewed as a calamity in a way that is, perhaps, disproportionate to its risk. A recent meta-analysis indicated that only around a fifth of individuals resumed alcohol consumption within five years of transplantation for decompensated ALD cirrhosis; recurrence of heavy drinking was less prevalent at 14%.<a id="xref-ref-152-1" class="xref-bibr" href="#ref-152">152</a> Psychiatric comorbidities, pre-transplant abstinence of less than six months, lack of social support including unmarried status, and smoking were associated with an increased risk of relapse. Harmful levels of drinking after transplantation may lead to an accelerated course of liver disease. Patients transplanted for ALD are at higher risk of cardiovascular disease and malignancy than patients transplanted for other indications.</p><p id="p-57">For many years, the six-month abstinence “rule” excluded transplantation in patients with severe AH despite the high short term mortality. A European consortium conducted landmark studies demonstrating that early transplantation improved survival compared with matched controls (77 ± 8% <em>v</em> 23 ± 8%, P<0.001 at six months) with only three of the 26 patients resuming any level of alcohol consumption.<a id="xref-ref-153-1" class="xref-bibr" href="#ref-153">153</a> Subsequent studies have replicated these results.<a id="xref-ref-154-1" class="xref-bibr" href="#ref-154">154</a> Despite this apparent effectiveness, controversy persists. The prognostic scoring systems used in AH are not sufficiently precise to identify those patients who will die without transplantation.<a id="xref-ref-155-1" class="xref-bibr" href="#ref-155">155</a> In a recent study, only four of 49 patients listed for early transplant recovered without transplant. However, 34 of the 95 patients who were not listed experienced a spontaneous recovery, though only a minority (7/34, 20%) achieved recompensated liver function.<a id="xref-ref-156-1" class="xref-bibr" href="#ref-156">156</a> The selection criteria for transplant candidates are not well defined, leading to heterogeneity between centers. Additionally, the recent surge in incidence of severe AH, secondary to mental health disorders arising during the covid-19 pandemic, have placed enormous additional demands on the limited supply of donor organs, leading to prolonged waiting times for patients with other liver disorders on transplant waiting lists.<a id="xref-ref-157-1" class="xref-bibr" href="#ref-157">157</a> Finally, a combination of legislation and professional attitudes make access to transplantation unavailable in some countries or centers. The UK, for example, currently has no program for transplantation for patients with AH.</p></div><div id="sec-24" class="subsection"><h3>Emerging treatments</h3><p id="p-58">As our understanding of the pathogenesis of AH improves, new treatment options are emerging. Therapeutic manipulation of the gut microbiome is a rational approach to treatment, although the sophisticated tools required for precision treatment are not yet available. However, early studies with fecal microbial transplantation (FMT) have been promising. A trial in India of FMT derived from healthy relatives in patients with AH and contraindications to steroids demonstrated remarkable improvement in survival relative to historical controls.<a id="xref-ref-158-1" class="xref-bibr" href="#ref-158">158</a> Clearly these results need to be replicated in prospective randomized trials, and it will be important to identify the crucial mechanisms conferring benefit to develop more specific interventions. The identification of the <em>E faecalis</em> cytolysin toxin provides one opportunity for more precise treatment targeting. Potentially this strain of <em>E faecalis</em> may be targeted using highly selective phages which could eliminate the bacterium from the host microbiome.<a id="xref-ref-30-3" class="xref-bibr" href="#ref-30">30</a></p><p id="p-59">Alternative targets for treatment are the regenerative failure and epigenetic dysregulation. Larsucosterol is an epigenetic modifier which has been evaluated in a phase 2 trial in patients with severe AH.<a id="xref-ref-159-1" class="xref-bibr" href="#ref-159">159</a> Early responses, judged by the Lille score, were superior to historical controls, providing support for an ongoing phase 3 study. Interleukin 22 (IL-22) is a pleotropic cytokine which stimulates both intestinal and hepatic epithelial regeneration. The IL-22 agonist F-652 has been evaluated in a phase 2 trial in AH demonstrating superior Lille responses and MELD score improvements relative to propensity-matched historical controls.<a id="xref-ref-160-1" class="xref-bibr" href="#ref-160">160</a></p></div></div><div class="section other14" id="sec-25"><h2 class="">Guidelines</h2><p id="p-60">Several specialist societies and healthcare bodies produce and maintain clinical management guidelines for ALD. The latest guidelines from the European Association for the Study of the Liver (EASL),<a id="xref-ref-3-5" class="xref-bibr" href="#ref-3">3</a> American Association for the Study of Liver Disease (AASLD),<a id="xref-ref-5-2" class="xref-bibr" href="#ref-5">5</a> American College of Gastroenterology (ACG)<a id="xref-ref-161-1" class="xref-bibr" href="#ref-161">161</a> and Latin American Association for the Study of the Liver (ALEH)<a id="xref-ref-162-1" class="xref-bibr" href="#ref-162">162</a> are summarized and compared in <a id="xref-table-wrap-2-1" class="xref-table" href="#T2">Table 2</a>.</p><div id="T2" class="table pos-float"><div class="table"><div class="table-caption"><span class="table-label">Table 2</span> <p id="p-61" class="first-child">A comparative assessment of recommendations from different specialist society guidelines on the management of alcohol-related liver disease (ALD)</p><div class="sb-div caption-clear"></div></div><div class="table-inline"><div class="callout"><span>View this table:</span><ul class="callout-links"><li><a href="/highwire/markup/1089997/expansion?width=1000&height=500&iframe=true&postprocessors=highwire_figures%2Chighwire_math" class="colorbox colorbox-load table-expand-popup" rel="gallery-fragment-tables">View popup</a></li><li><a href="" class="table-expand-inline" data-table-url="/highwire/markup/1089997/expansion?postprocessors=highwire_figures%2Chighwire_math">View inline</a></li></ul></div></div></div><div></div></div></div><div class="section conclusions" id="sec-26"><h2 class="">Conclusions</h2><p id="p-63">The link between alcohol excess and the development of liver disease is long established. However, population-level changes in drinking behaviors and a lack of concerted global and national public health interventions mean that ALD disease burden is rising. Significant recent efforts and technological developments offer the opportunity to use non-invasive tools to screen for, diagnose, and stage ALD before the development of cirrhosis, giving a window for intervention before the development of established disease. Alcohol abstinence is and always will be the mainstay of disease therapy. Brief interventions help reduce harmful alcohol use, but a more holistic and integrated approach to the management of alcohol use disorders, incorporating primary care, mental health, addiction and liver specialists with consideration of pharmacotherapy, is likely necessary to improve outcomes in those with severe dependence. Beyond this, there is a total absence of disease-modifying treatments in ALD. As the body of knowledge regarding the pathogenetic mechanisms increases, the opportunity to identify new targets for therapies does too. The shared genetic liability with non-alcoholic fatty liver disease, another liver disease with significant unmet clinical need, hints at the possibility that certain treatments may show common benefit in both conditions. Translating these opportunities into successful treatment strategies will require an enabling environment, which, in large part, requires a commitment from policymakers to give ALD the attention and resource commensurate to its prevalence and associated disease burden.</p><div class="boxed-text" id="boxed-text-1"><h3>Questions for future research </h3><ul class="list-unord " id="list-1"><li id="list-item-1"><p id="p-64">Are we able to develop and implement early diagnosis strategies to prevent progression to identify harmful drinking behavior and prevent end-stage liver disease?</p></li><li id="list-item-2"><p id="p-65">Can we develop a strategy to reduce stigmatization in alcohol use disorder among medical professionals and public?</p></li><li id="list-item-3"><p id="p-66">Can the intestinal microbiome be manipulated to treat or prevent alcohol-related liver disease without resorting to fecal microbial transplantation?</p></li><li id="list-item-4"><p id="p-67">Is it possible to develop pharmacotherapy to preserve or restore liver function while awaiting resolution of alcohol use?</p></li><li id="list-item-5"><p id="p-68">Can we improve the pharmacotherapy for alcohol use disorder in patients with advanced liver disease?</p></li></ul></div><div class="boxed-text" id="boxed-text-2"><h3>Glossary of abbreviations</h3><ul class="list-simple " id="list-2"><li id="list-item-6"><p id="p-69">AASLD: American Association for the Study of Liver Disease</p></li><li id="list-item-7"><p id="p-70">AH: Alcohol-related hepatitis</p></li><li id="list-item-8"><p id="p-71">ALD: Alcohol-related liver disease</p></li><li id="list-item-9"><p id="p-72">APRI: AST to platelet ratio index</p></li><li id="list-item-10"><p id="p-73">ASH: Steatohepatitis due to alcohol-related liver disease</p></li><li id="list-item-11"><p id="p-74">AUD: Alcohol use disorder</p></li><li id="list-item-12"><p id="p-75">CIWA: Clinical Institute Withdrawal Assessment for Alcohol protocol</p></li><li id="list-item-13"><p id="p-76">DSM: Diagnostic and Statistical Manual of Mental Disorders</p></li><li id="list-item-14"><p id="p-77">EASL: European Association for the Study of the Liver</p></li><li id="list-item-15"><p id="p-78">FIB-4: Fibrosis-4</p></li><li id="list-item-16"><p id="p-79">HCC: Hepatocellular carcinoma</p></li><li id="list-item-17"><p id="p-80">ICD: International classification of disease</p></li><li id="list-item-18"><p id="p-81">LSM: Liver stiffness measurement</p></li><li id="list-item-19"><p id="p-82">MOR: Mu opiate receptor</p></li><li id="list-item-20"><p id="p-83">MUP: Minimum unit price</p></li><li id="list-item-21"><p id="p-84">TLR: Toll-like receptor</p></li><li id="list-item-22"><p id="p-85">VTA: Ventral tegmental area</p></li></ul></div></div><div class="section ack" id="ack-1"><h2>Acknowledgments</h2><p id="p-86">We acknowledge support from the NIHR-Imperial Biomedical Research Centre. We are grateful for critical input from Dr Stephen Atkinson.</p></div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-other" id="fn-1"><p id="p-2">State of the Art Reviews are commissioned on the basis of their relevance to academics and specialists in the US and internationally. For this reason they are written predominantly by US authors</p></li><li class="fn-other" id="fn-3"><p id="p-87">Contributors: All authors contributed to the planning, writing and review of the article. The corresponding author acts as the guarantor for the article and attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.</p></li><li class="fn-conflict" id="fn-4"><p id="p-88">Competing interests: ALH declares honorarium from Lundbeck for lecture/training and royalties from editorship of <em>Edwards' Treatment of Drinking Problems: A Guide for the Helping Professions</em>. MT declares consultancy fees from GSK, Durect, Intercept, and Surrozen.</p></li><li class="fn-other" id="fn-5"><p id="p-89">Patient involvement: No patients were asked for input in the creation of this article.</p></li><li class="fn-other" id="fn-6"><p id="p-90">Provenance and peer review: Commissioned; externally peer reviewed.</p></li></ul></div><div class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.1" data-doi="10.1111/j.1365-2036.2008.03831.x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Nguyen-Khac</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chatelain</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tramier</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Assessment of asymptomatic liver fibrosis in alcoholic patients using fibroscan: prospective comparison with seven non-invasive laboratory tests</span>. <abbr class="cit-jnl-abbrev">Aliment Pharmacol Ther</abbr><span class="cit-pub-date">2008</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">1188</span>-<span class="cit-lpage">98</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1365-2036.2008.03831.x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18705692</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlimentary%2Bpharmacology%2B%2526%2Btherapeutics%26rft.stitle%253DAliment%2BPharmacol%2BTher%26rft.aulast%253DNguyen-Khac%26rft.auinit1%253DE.%26rft.volume%253D28%26rft.issue%253D10%26rft.spage%253D1188%26rft.epage%253D1198%26rft.atitle%253DAssessment%2Bof%2Basymptomatic%2Bliver%2Bfibrosis%2Bin%2Balcoholic%2Bpatients%2Busing%2Bfibroscan%253A%2Bprospective%2Bcomparison%2Bwith%2Bseven%2Bnon-invasive%2Blaboratory%2Btests.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1365-2036.2008.03831.x%26rft_id%253Dinfo%253Apmid%252F18705692%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/j.1365-2036.2008.03831.x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18705692&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2 in text" id="ref-2">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.2" data-doi="10.1016/j.ebiom.2019.03.046"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Parker</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span> <span class="cit-name-given-names">SJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Im</span> <span class="cit-name-given-names">GY</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Obesity in acute alcoholic hepatitis increases morbidity and mortality</span>. <abbr class="cit-jnl-abbrev">EBioMedicine</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">45</span>:<span class="cit-fpage">511</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.ebiom.2019.03.046</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31278069</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DEBioMedicine%26rft.volume%253D45%26rft.spage%253D511%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.ebiom.2019.03.046%26rft_id%253Dinfo%253Apmid%252F31278069%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.ebiom.2019.03.046&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31278069&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3 in text" id="ref-3">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.3" data-doi="10.1016/j.jhep.2018.03.018"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">European Association for the Study of the Liver</span></li></ol><cite>. <span class="cit-article-title">EASL Clinical Practice Guidelines: Management of alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">69</span>:<span class="cit-fpage">154</span>-<span class="cit-lpage">81</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2018.03.018</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29628280</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D69%26rft.spage%253D154%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2018.03.018%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2018.03.018&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4 in text" id="ref-4">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.4" data-doi="10.1053/j.gastro.2016.02.042"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Crabb</span> <span class="cit-name-given-names">DW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bataller</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chalasani</span> <span class="cit-name-given-names">NP</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">NIAAA Alcoholic Hepatitis Consortia</span></li></ol><cite>. <span class="cit-article-title">Standard definitions and common data elements for clinical trials in patients with alcoholic hepatitis: recommendation from the NIAAA Alcoholic Hepatitis Consortia</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">150</span>:<span class="cit-fpage">785</span>-<span class="cit-lpage">90</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2016.02.042</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26921783</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D150%26rft.spage%253D785%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2016.02.042%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2016.02.042&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5 in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.5" data-doi="10.1002/hep.30866"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Crabb</span> <span class="cit-name-given-names">DW</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Im</span> <span class="cit-name-given-names">GY</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Szabo</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mellinger</span> <span class="cit-name-given-names">JL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lucey</span> <span class="cit-name-given-names">MR</span></span></li></ol><cite>. <span class="cit-article-title">Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American Association for the Study of Liver Diseases</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">71</span>:<span class="cit-fpage">306</span>-<span class="cit-lpage">33</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.30866</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31314133</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D71%26rft.spage%253D306%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.30866%26rft_id%253Dinfo%253Apmid%252F31314133%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.30866&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31314133&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-6-1" title="View reference 6 in text" id="ref-6">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.6" data-doi="10.1016/S0140-6736(18)31310-2"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">GBD 2016 Alcohol Collaborators</span></li></ol><cite>. <span class="cit-article-title">Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016</span>. <abbr class="cit-jnl-abbrev">Lancet</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">392</span>:<span class="cit-fpage">1015</span>-<span class="cit-lpage">35</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0140-6736(18)31310-2</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30146330</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252818%252931310-2%26rft_id%253Dinfo%253Apmid%252F30146330%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S0140-6736(18)31310-2&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30146330&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-7-1" title="View reference 7 in text" id="ref-7">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.7" data-doi="10.1016/S2215-0366(18)30337-7"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">GBD 2016 Alcohol and Drug Use Collaborators</span></li></ol><cite>. <span class="cit-article-title">The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016</span>. <abbr class="cit-jnl-abbrev">Lancet Psychiatry</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">987</span>-<span class="cit-lpage">1012</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2215-0366(18)30337-7</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30392731</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BPsychiatry%26rft.volume%253D5%26rft.spage%253D987%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2215-0366%252818%252930337-7%26rft_id%253Dinfo%253Apmid%252F30392731%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2215-0366(18)30337-7&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30392731&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-8-1" title="View reference 8 in text" id="ref-8">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.8" data-doi="10.1016/S2468-1253(19)30349-8"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">GBD 2017 Cirrhosis Collaborators</span></li></ol><cite>. <span class="cit-article-title">The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">245</span>-<span class="cit-lpage">66</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(19)30349-8</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31981519</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D5%26rft.spage%253D245%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252819%252930349-8%26rft_id%253Dinfo%253Apmid%252F31981519%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(19)30349-8&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31981519&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-9-1" title="View reference 9 in text" id="ref-9">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.9" data-doi="10.1001/jamainternmed.2018.6536"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lee</span> <span class="cit-name-given-names">BP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vittinghoff</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dodge</span> <span class="cit-name-given-names">JL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cullaro</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Terrault</span> <span class="cit-name-given-names">NA</span></span></li></ol><cite>. <span class="cit-article-title">National trends and long-term outcomes of liver transplant for alcohol-associated liver disease in the United States</span>. <abbr class="cit-jnl-abbrev">JAMA Intern Med</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">179</span>:<span class="cit-fpage">340</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1001/jamainternmed.2018.6536</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30667468</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJAMA%2BIntern%2BMed%26rft.volume%253D179%26rft.spage%253D340%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjamainternmed.2018.6536%26rft_id%253Dinfo%253Apmid%252F30667468%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1001/jamainternmed.2018.6536&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30667468&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-10-1" title="View reference 10 in text" id="ref-10">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.10"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">European Liver Transplant Registry</span></li></ol><cite>. <span class="cit-pub-date">2011</span><a href="http://www.eltr.org">http://www.eltr.org</a>.</cite></div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-11-1" title="View reference 11 in text" id="ref-11">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.11"><div class="cit-metadata unstructured">NHS Blood and Transplant. Annual report on liver transplantation 2021/2022. 2022 <a href="https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/27814/nhsbt-liver-transplant-report-2122-final.pdf">https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/27814/nhsbt-liver-transplant-report-2122-final.pdf</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-12-1" title="View reference 12 in text" id="ref-12">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.12" data-doi="10.1016/j.jhep.2015.11.006"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Sheron</span> <span class="cit-name-given-names">N</span></span></li></ol><cite>. <span class="cit-article-title">Alcohol and liver disease in Europe--Simple measures have the potential to prevent tens of thousands of premature deaths</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">64</span>:<span class="cit-fpage">957</span>-<span class="cit-lpage">67</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2015.11.006</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26592352</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D64%26rft.spage%253D957%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2015.11.006%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2015.11.006&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-13-1" title="View reference 13 in text" id="ref-13">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.13" data-doi="10.1016/S0140-6736(18)32744-2"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Manthey</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shield</span> <span class="cit-name-given-names">KD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rylett</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hasan</span> <span class="cit-name-given-names">OSM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Probst</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rehm</span> <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study</span>. <abbr class="cit-jnl-abbrev">Lancet</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">393</span>:<span class="cit-fpage">2493</span>-<span class="cit-lpage">502</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0140-6736(18)32744-2</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31076174</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252818%252932744-2%26rft_id%253Dinfo%253Apmid%252F31076174%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S0140-6736(18)32744-2&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31076174&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-14-1" title="View reference 14 in text" id="ref-14">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.14" data-doi="10.1016/S2468-2667(20)30062-1"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Julien</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ayer</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bethea</span> <span class="cit-name-given-names">ED</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tapper</span> <span class="cit-name-given-names">EB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chhatwal</span> <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019-40: a modelling study</span>. <abbr class="cit-jnl-abbrev">Lancet Public Health</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">e316</span>-<span class="cit-lpage">23</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-2667(20)30062-1</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32504584</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BPublic%2BHealth%26rft.volume%253D5%26rft.spage%253D316e%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-2667%252820%252930062-1%26rft_id%253Dinfo%253Apmid%252F32504584%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-2667(20)30062-1&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32504584&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-15-1" title="View reference 15 in text" id="ref-15">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.15" data-doi="10.1097/MCG.0000000000001665"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Damjanovska</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Karb</span> <span class="cit-name-given-names">DB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cohen</span> <span class="cit-name-given-names">SM</span></span></li></ol><cite>. <span class="cit-article-title">Increasing prevalence and racial disparity of alcohol-related gastrointestinal and liver disease during the COVID-19 pandemic: a population-based national study</span>. <abbr class="cit-jnl-abbrev">J Clin Gastroenterol</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">57</span>:<span class="cit-fpage">185</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/MCG.0000000000001665</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34999643</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BClin%2BGastroenterol%26rft.volume%253D57%26rft.spage%253D185%26rft_id%253Dinfo%253Adoi%252F10.1097%252FMCG.0000000000001665%26rft_id%253Dinfo%253Apmid%252F34999643%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1097/MCG.0000000000001665&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34999643&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-16-1" title="View reference 16 in text" id="ref-16">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.16" data-doi="10.1016/S2468-1253(20)30251-X"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kim</span> <span class="cit-name-given-names">JU</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Majid</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Judge</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Effect of COVID-19 lockdown on alcohol consumption in patients with pre-existing alcohol use disorder</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">886</span>-<span class="cit-lpage">7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(20)30251-X</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32763197</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D5%26rft.spage%253D886%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252820%252930251-X%26rft_id%253Dinfo%253Apmid%252F32763197%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(20)30251-X&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32763197&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-17-1" title="View reference 17 in text" id="ref-17">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.17" data-doi="10.1111/dar.13446"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kilian</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">O’Donnell</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Potapova</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Changes in alcohol use during the COVID-19 pandemic in Europe: A meta-analysis of observational studies</span>. <abbr class="cit-jnl-abbrev">Drug Alcohol Rev</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">41</span>:<span class="cit-fpage">918</span>-<span class="cit-lpage">31</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/dar.13446</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35187739</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DDrug%2BAlcohol%2BRev%26rft.volume%253D41%26rft.spage%253D918%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fdar.13446%26rft_id%253Dinfo%253Apmid%252F35187739%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/dar.13446&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35187739&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-18-1" title="View reference 18 in text" id="ref-18">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.18"><div class="cit-metadata unstructured">National Institute for Health and Care Excellence. Alcohol-use disorders: prevention (public health guideline PH24). 2010. <a href="https://www.nice.org.uk/guidance/ph24">https://www.nice.org.uk/guidance/ph24</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-19-1" title="View reference 19 in text" id="ref-19">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.19"><div class="cit-metadata unstructured">World Health Organization. Tackling NCDs: 'best buys' and other recommended interventions for the prevention and control of noncommunicable diseases. 2017. <a href="https://apps.who.int/iris/handle/10665/259232">https://apps.who.int/iris/handle/10665/259232</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-20-1" title="View reference 20 in text" id="ref-20">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.20"><div class="cit-metadata unstructured">Institute of Alcohol Studies. Alcohol information and education factsheet. 2014. <a href="https://www.ias.org.uk/uploads/pdf/Factsheets/Alcohol%20information%20and%20education%20factsheet%20March%202014.pdf">https://www.ias.org.uk/uploads/pdf/Factsheets/Alcohol%20information%20and%20education%20factsheet%20March%202014.pdf</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-21-1" title="View reference 21 in text" id="ref-21">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.21"><div class="cit-metadata unstructured">World Health Organization. No place for cheap alcohol: the potential value of minimum pricing for protecting lives. 2022. <a href="https://www.who.int/europe/publications/i/item/9789289058094">https://www.who.int/europe/publications/i/item/9789289058094</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-22-1" title="View reference 22 in text" id="ref-22">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.22" data-doi="10.1016/S2468-2667(21)00052-9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Anderson</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">O’Donnell</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kaner</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Llopis</span> <span class="cit-name-given-names">EJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Manthey</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rehm</span> <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Impact of minimum unit pricing on alcohol purchases in Scotland and Wales: controlled interrupted time series analyses</span>. <abbr class="cit-jnl-abbrev">Lancet Public Health</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">6</span>:<span class="cit-fpage">e557</span>-<span class="cit-lpage">65</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-2667(21)00052-9</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34058125</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BPublic%2BHealth%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-2667%252821%252900052-9%26rft_id%253Dinfo%253Apmid%252F34058125%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-2667(21)00052-9&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34058125&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-23-1" title="View reference 23 in text" id="ref-23">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.23" data-doi="10.1136/bmjopen-2021-054161"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Rehm</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">O’Donnell</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kaner</span> <span class="cit-name-given-names">EFS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jane LLopis</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Manthey</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Anderson</span> <span class="cit-name-given-names">P</span></span></li></ol><cite>. <span class="cit-article-title">Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis</span>. <abbr class="cit-jnl-abbrev">BMJ Open</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">12</span>:<span class="cit-elocation-id">e054161</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/bmjopen-2021-054161</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35851006</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBMJ%2BOpen%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fbmjopen-2021-054161%26rft_id%253Dinfo%253Apmid%252F35851006%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NzoiYm1qb3BlbiI7czo1OiJyZXNpZCI7czoxMjoiMTIvNy9lMDU0MTYxIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-24-1" title="View reference 24 in text" id="ref-24">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.24" data-doi="10.3310/phr09110"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">So</span> <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Millard</span> <span class="cit-name-given-names">AD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Katikireddi</span> <span class="cit-name-given-names">SV</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Intended and unintended consequences of the implementation of minimum unit pricing of alcohol in Scotland: a natural experiment</span>. <abbr class="cit-jnl-abbrev">Public Health Research</abbr><span class="cit-pub-date">2021</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3310/phr09110</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34699154</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPublic%2BHealth%2BResearch%26rft_id%253Dinfo%253Adoi%252F10.3310%252Fphr09110%26rft_id%253Dinfo%253Apmid%252F34699154%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.3310/phr09110&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34699154&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-25-1" title="View reference 25 in text" id="ref-25">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.25"><div class="cit-metadata unstructured">Holmes J. Evaluating the impact of Minimum Unit Pricing in Scotland on people who are drinking at harmful levels: Final report. Public Health Scotland, 2022. <a href="https://www.publichealthscotland.scot/media/13486/evaluating-the-impact-of-minimum-unit-pricing-in-scotland-on-people-who-are-drinking-at-harmful-levels-report.pdf">https://www.publichealthscotland.scot/media/13486/evaluating-the-impact-of-minimum-unit-pricing-in-scotland-on-people-who-are-drinking-at-harmful-levels-report.pdf</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-26-1" title="View reference 26 in text" id="ref-26">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.26" data-doi="10.1093/alcalc/agab051"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Chaudhary</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">MacKey</span> <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Duncan</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Forrest</span> <span class="cit-name-given-names">EH</span></span></li></ol><cite>. <span class="cit-article-title">Changes in hospital discharges with alcohol-related liver disease in a gastroenterology and general medical unit following the introduction of minimum unit pricing of alcohol: the GRI Q4 Study</span>. <abbr class="cit-jnl-abbrev">Alcohol Alcohol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">57</span>:<span class="cit-fpage">477</span>-<span class="cit-lpage">82</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/alcalc/agab051</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34343256</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlcohol%2BAlcohol%26rft.volume%253D57%26rft.spage%253D477%26rft_id%253Dinfo%253Adoi%252F10.1093%252Falcalc%252Fagab051%26rft_id%253Dinfo%253Apmid%252F34343256%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1093/alcalc/agab051&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34343256&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-27-1" title="View reference 27 in text" id="ref-27">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.27" data-doi="10.1111/add.13902"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Zhao</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stockwell</span> <span class="cit-name-given-names">T</span></span></li></ol><cite>. <span class="cit-article-title">The impacts of minimum alcohol pricing on alcohol attributable morbidity in regions of British Colombia, Canada with low, medium and high mean family income</span>. <abbr class="cit-jnl-abbrev">Addiction</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">112</span>:<span class="cit-fpage">1942</span>-<span class="cit-lpage">51</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/add.13902</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28600882</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddiction%26rft.volume%253D112%26rft.spage%253D1942%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fadd.13902%26rft_id%253Dinfo%253Apmid%252F28600882%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/add.13902&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28600882&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-28-1" title="View reference 28 in text" id="ref-28">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.28" data-doi="10.1016/j.jhepr.2020.100220"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Fairfield</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schnabl</span> <span class="cit-name-given-names">B</span></span></li></ol><cite>. <span class="cit-article-title">Gut dysbiosis as a driver in alcohol-induced liver injury</span>. <abbr class="cit-jnl-abbrev">JHEP Rep</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">3</span>:<span class="cit-elocation-id">100220</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhepr.2020.100220</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33598648</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJHEP%2BRep%26rft.volume%253D3%26rft.spage%253D100220%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhepr.2020.100220%26rft_id%253Dinfo%253Apmid%252F33598648%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhepr.2020.100220&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33598648&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-29-1" title="View reference 29 in text" id="ref-29">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.29" data-doi="10.1136/gutjnl-2015-310585"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Llopis</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cassard</span> <span class="cit-name-given-names">AM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wrzosek</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Gut</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">65</span>:<span class="cit-fpage">830</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/gutjnl-2015-310585</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26642859</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgutjnl-2015-310585%26rft_id%253Dinfo%253Apmid%252F26642859%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NjoiZ3V0am5sIjtzOjU6InJlc2lkIjtzOjg6IjY1LzUvODMwIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-30-1" title="View reference 30 in text" id="ref-30">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.30" data-doi="10.1038/s41586-019-1742-x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Duan</span> <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Llorente</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lang</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Nature</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">575</span>:<span class="cit-fpage">505</span>-<span class="cit-lpage">11</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41586-019-1742-x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31723265</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNature%26rft.volume%253D575%26rft.spage%253D505%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41586-019-1742-x%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41586-019-1742-x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-31-1" title="View reference 31 in text" id="ref-31">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.31" data-doi="10.1080/19490976.2020.1782157"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Maccioni</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gao</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leclercq</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans</span>. <abbr class="cit-jnl-abbrev">Gut Microbes</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">12</span>:<span class="cit-elocation-id">1782157</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1080/19490976.2020.1782157</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32588725</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%2BMicrobes%26rft.volume%253D12%26rft.spage%253D1782157%26rft_id%253Dinfo%253Adoi%252F10.1080%252F19490976.2020.1782157%26rft_id%253Dinfo%253Apmid%252F32588725%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1080/19490976.2020.1782157&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32588725&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-32-1" title="View reference 32 in text" id="ref-32">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.32" data-doi="10.1002/hep.28456"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Tilg</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Moschen</span> <span class="cit-name-given-names">AR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Szabo</span> <span class="cit-name-given-names">G</span></span></li></ol><cite>. <span class="cit-article-title">Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">64</span>:<span class="cit-fpage">955</span>-<span class="cit-lpage">65</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.28456</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26773297</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D64%26rft.spage%253D955%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.28456%26rft_id%253Dinfo%253Apmid%252F26773297%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.28456&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26773297&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-33-1" title="View reference 33 in text" id="ref-33">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.33" data-doi="10.1152/physrev.1997.77.2.517"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lieber</span> <span class="cit-name-given-names">CS</span></span></li></ol><cite>. <span class="cit-article-title">Cytochrome P-4502E1: its physiological and pathological role</span>. <abbr class="cit-jnl-abbrev">Physiol Rev</abbr><span class="cit-pub-date">1997</span>;<span class="cit-vol">77</span>:<span class="cit-fpage">517</span>-<span class="cit-lpage">44</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1152/physrev.1997.77.2.517</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9114822</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPhysiological%2BReviews%26rft.stitle%253DPhysiol.%2BRev.%26rft.aulast%253DLieber%26rft.auinit1%253DC.%2BS.%26rft.volume%253D77%26rft.issue%253D2%26rft.spage%253D517%26rft.epage%253D544%26rft.atitle%253DCytochrome%2BP-4502E1%253A%2Bits%2Bphysiological%2Band%2Bpathological%2Brole%26rft_id%253Dinfo%253Adoi%252F10.1152%252Fphysrev.1997.77.2.517%26rft_id%253Dinfo%253Apmid%252F9114822%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1152/physrev.1997.77.2.517&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9114822&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1997WV25700007&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-34-1" title="View reference 34 in text" id="ref-34">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.34" data-doi="10.1093/ajcn/76.5.1177S"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Martínez-Chantar</span> <span class="cit-name-given-names">ML</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">García-Trevijano</span> <span class="cit-name-given-names">ER</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Latasa</span> <span class="cit-name-given-names">MU</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury</span>. <abbr class="cit-jnl-abbrev">Am J Clin Nutr</abbr><span class="cit-pub-date">2002</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">1177S</span>-<span class="cit-lpage">82S</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/ajcn/76.5.1177S</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12418501</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DThe%2BAmerican%2BJournal%2Bof%2BClinical%2BNutrition%26rft.stitle%253DAm%2BJ%2BClin%2BNutr%26rft.aulast%253DMartinez-Chantar%26rft.auinit1%253DM%2BL.%26rft.volume%253D76%26rft.issue%253D5%26rft.spage%253D1177S%26rft.epage%253D1182S%26rft.atitle%253DImportance%2Bof%2Ba%2Bdeficiency%2Bin%2BS-adenosyl-L-methionine%2Bsynthesis%2Bin%2Bthe%2Bpathogenesis%2Bof%2Bliver%2Binjury%26rft_id%253Dinfo%253Adoi%252F10.1093%252Fajcn%252F76.5.1177S%26rft_id%253Dinfo%253Apmid%252F12418501%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpjbiI7czo1OiJyZXNpZCI7czoxMDoiNzYvNS8xMTc3UyI7czo0OiJhdG9tIjtzOjI5OiIvYm1qLzM4My9ibWotMjAyMy0wNzcwOTAuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-35-1" title="View reference 35 in text" id="ref-35">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.35" data-doi="10.1016/j.jhep.2018.10.037"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">You</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Arteel</span> <span class="cit-name-given-names">GE</span></span></li></ol><cite>. <span class="cit-article-title">Effect of ethanol on lipid metabolism</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">70</span>:<span class="cit-fpage">237</span>-<span class="cit-lpage">48</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2018.10.037</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30658725</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D70%26rft.spage%253D237%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2018.10.037%26rft_id%253Dinfo%253Apmid%252F30658725%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2018.10.037&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30658725&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-36-1" title="View reference 36 in text" id="ref-36">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.36" data-doi="10.1074/jbc.M202411200"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">You</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fischer</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Deeg</span> <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Crabb</span> <span class="cit-name-given-names">DW</span></span></li></ol><cite>. <span class="cit-article-title">Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)</span>. <abbr class="cit-jnl-abbrev">J Biol Chem</abbr><span class="cit-pub-date">2002</span>;<span class="cit-vol">277</span>:<span class="cit-fpage">29342</span>-<span class="cit-lpage">7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1074/jbc.M202411200</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>12036955</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BBiol%2BChem%26rft_id%253Dinfo%253Adoi%252F10.1074%252Fjbc.M202411200%26rft_id%253Dinfo%253Apmid%252F12036955%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamJjIjtzOjU6InJlc2lkIjtzOjEyOiIyNzcvMzIvMjkzNDIiO3M6NDoiYXRvbSI7czoyOToiL2Jtai8zODMvYm1qLTIwMjMtMDc3MDkwLmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-37-1" title="View reference 37 in text" id="ref-37">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.37" data-doi="10.2310/JIM.0b013e31827c2795"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Liangpunsakul</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ross</span> <span class="cit-name-given-names">RA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Crabb</span> <span class="cit-name-given-names">DW</span></span></li></ol><cite>. <span class="cit-article-title">Activation of carbohydrate response element-binding protein by ethanol</span>. <abbr class="cit-jnl-abbrev">J Investig Med</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">61</span>:<span class="cit-fpage">270</span>-<span class="cit-lpage">7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.2310/JIM.0b013e31827c2795</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23266705</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJournal%2Bof%2BInvestigative%2BMedicine%26rft.stitle%253DJ%2BInvestig%2BMed%26rft.aulast%253DLiangpunsakul%26rft.auinit1%253DS.%26rft.volume%253D61%26rft.issue%253D2%26rft.spage%253D270%26rft.epage%253D277%26rft.atitle%253DActivation%2Bof%2BCarbohydrate%2BResponse%2BElement-Binding%2BProtein%2Bby%2BEthanol%26rft_id%253Dinfo%253Adoi%252F10.2310%252FJIM.0b013e31827c2795%26rft_id%253Dinfo%253Apmid%252F23266705%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamltIjtzOjU6InJlc2lkIjtzOjg6IjYxLzIvMjcwIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-38-1" title="View reference 38 in text" id="ref-38">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.38" data-doi="10.7861/clinmedicine.18-2-s54"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Scott</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Anstee</span> <span class="cit-name-given-names">QM</span></span></li></ol><cite>. <span class="cit-article-title">Genetics of alcoholic liver disease and non-alcoholic steatohepatitis</span>. <abbr class="cit-jnl-abbrev">Clin Med (Lond)</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">18</span>(<span class="cit-supplement">Suppl 2</span>):<span class="cit-fpage">s54</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.7861/clinmedicine.18-2-s54</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29700094</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClinical%2BMedicine%26rft.stitle%253DClin%2BMed%26rft.aulast%253DScott%26rft.auinit1%253DE.%26rft.volume%253D18%26rft.issue%253DSuppl_2%26rft.spage%253Ds54%26rft.epage%253Ds59%26rft.atitle%253DGenetics%2Bof%2Balcoholic%2Bliver%2Bdisease%2Band%2Bnon-alcoholic%2Bsteatohepatitis%26rft_id%253Dinfo%253Adoi%252F10.7861%252Fclinmedicine.18-2-s54%26rft_id%253Dinfo%253Apmid%252F29700094%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MTI6ImNsaW5tZWRpY2luZSI7czo1OiJyZXNpZCI7czoxNDoiMTgvU3VwcGxfMi9zNTQiO3M6NDoiYXRvbSI7czoyOToiL2Jtai8zODMvYm1qLTIwMjMtMDc3MDkwLmF0b20iO31zOjg6ImZyYWdtZW50IjtzOjA6IiI7fQ==" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-39-1" title="View reference 39 in text" id="ref-39">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.39" data-doi="10.1056/NEJMra0805786"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lucey</span> <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mathurin</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morgan</span> <span class="cit-name-given-names">TR</span></span></li></ol><cite>. <span class="cit-article-title">Alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr><span class="cit-pub-date">2009</span>;<span class="cit-vol">360</span>:<span class="cit-fpage">2758</span>-<span class="cit-lpage">69</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMra0805786</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19553649</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DLucey%26rft.auinit1%253DM.%2BR.%26rft.volume%253D360%26rft.issue%253D26%26rft.spage%253D2758%26rft.epage%253D2769%26rft.atitle%253DAlcoholic%2Bhepatitis.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMra0805786%26rft_id%253Dinfo%253Apmid%252F19553649%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1056/NEJMra0805786&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19553649&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000267286600010&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-40-1" title="View reference 40 in text" id="ref-40">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.40" data-doi="10.1038/s41467-019-11004-3"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Argemi</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Latasa</span> <span class="cit-name-given-names">MU</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Atkinson</span> <span class="cit-name-given-names">SR</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">Nat Commun</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">10</span>:<span class="cit-fpage">3126</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41467-019-11004-3</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31311938</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNat%2BCommun%26rft.volume%253D10%26rft.spage%253D3126%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41467-019-11004-3%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41467-019-11004-3&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-41-1" title="View reference 41 in text" id="ref-41">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.41" data-doi="10.1371/journal.pone.0072904"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Aravinthan</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pietrosi</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hoare</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">PLoS One</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">8</span>:<span class="cit-elocation-id">e72904</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1371/journal.pone.0072904</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24086266</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPLoS%2BOne%26rft.volume%253D8%26rft.spage%253De72904%26rft_id%253Dinfo%253Adoi%252F10.1371%252Fjournal.pone.0072904%26rft_id%253Dinfo%253Apmid%252F24086266%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1371/journal.pone.0072904&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24086266&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-42-1" title="View reference 42 in text" id="ref-42">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.42" data-doi="10.1136/gutjnl-2014-308410"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Dubuquoy</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Louvet</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lassailly</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">Gut</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">64</span>:<span class="cit-fpage">1949</span>-<span class="cit-lpage">60</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/gutjnl-2014-308410</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25731872</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgutjnl-2014-308410%26rft_id%253Dinfo%253Apmid%252F25731872%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NjoiZ3V0am5sIjtzOjU6InJlc2lkIjtzOjEwOiI2NC8xMi8xOTQ5IjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-43-1" title="View reference 43 in text" id="ref-43">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.43" data-doi="10.1016/j.jhep.2016.11.011"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lackner</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Spindelboeck</span> <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Haybaeck</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">66</span>:<span class="cit-fpage">610</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2016.11.011</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27894795</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D66%26rft.spage%253D610%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2016.11.011%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2016.11.011&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-44-1" title="View reference 44 in text" id="ref-44">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.44" data-doi="10.1016/j.jhep.2021.05.029"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lackner</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stauber</span> <span class="cit-name-given-names">RE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Davies</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">75</span>:<span class="cit-fpage">810</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2021.05.029</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34126105</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D75%26rft.spage%253D810%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2021.05.029%26rft_id%253Dinfo%253Apmid%252F34126105%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2021.05.029&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34126105&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-45-1" title="View reference 45 in text" id="ref-45">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.45" data-doi="10.1111/liv.12242"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Masson</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Emmerson</span> <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Henderson</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Clinical but not histological factors predict long-term prognosis in patients with histologically advanced non-decompensated alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Liver Int</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">235</span>-<span class="cit-lpage">42</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/liv.12242</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23834275</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLiver%2BInt%26rft.volume%253D34%26rft.spage%253D235%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fliv.12242%26rft_id%253Dinfo%253Apmid%252F23834275%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/liv.12242&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23834275&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-46-1" title="View reference 46 in text" id="ref-46">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.46" data-doi="10.1016/j.jhep.2019.12.023"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Degré</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stauber</span> <span class="cit-name-given-names">RE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Englebert</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Long-term outcomes in patients with decompensated alcohol-related liver disease, steatohepatitis and Maddrey’s discriminant function <32</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">72</span>:<span class="cit-fpage">636</span>-<span class="cit-lpage">42</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2019.12.023</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31954208</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D72%26rft.spage%253D636%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2019.12.023%26rft_id%253Dinfo%253Apmid%252F31954208%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2019.12.023&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31954208&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-47-1" title="View reference 47 in text" id="ref-47">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.47" data-doi="10.1136/gutjnl-2019-320446"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Hagström</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Roelstraete</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Söderling</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ludvigsson</span> <span class="cit-name-given-names">JF</span></span></li></ol><cite>. <span class="cit-article-title">Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients</span>. <abbr class="cit-jnl-abbrev">Gut</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">70</span>:<span class="cit-fpage">170</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/gutjnl-2019-320446</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32220902</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgutjnl-2019-320446%26rft_id%253Dinfo%253Apmid%252F32220902%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NjoiZ3V0am5sIjtzOjU6InJlc2lkIjtzOjg6IjcwLzEvMTcwIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-48-1" title="View reference 48 in text" id="ref-48">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.48" data-doi="10.1186/1471-230X-14-166"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Haflidadottir</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jonasson</span> <span class="cit-name-given-names">JG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Norland</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Long-term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic related fatty liver disease</span>. <abbr class="cit-jnl-abbrev">BMC Gastroenterol</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">14</span>:<span class="cit-fpage">166</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/1471-230X-14-166</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25260964</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBMC%2BGastroenterol%26rft.volume%253D14%26rft.spage%253D166%26rft_id%253Dinfo%253Adoi%252F10.1186%252F1471-230X-14-166%26rft_id%253Dinfo%253Apmid%252F25260964%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1186/1471-230X-14-166&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25260964&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-49-1" title="View reference 49 in text" id="ref-49">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.49" data-doi="10.5604/16652681.1193707"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Shoreibah</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Raff</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bloomer</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver diseas</span>. <abbr class="cit-jnl-abbrev">Ann Hepatol</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">15</span>:<span class="cit-fpage">183</span>-<span class="cit-lpage">9</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.5604/16652681.1193707</span><span class="cit-pub-id-sep cit-pub-id-doi-sep">.</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26845595</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAnn%2BHepatol%26rft.volume%253D15%26rft.spage%253D183%26rft_id%253Dinfo%253Adoi%252F10.5604%252F16652681.1193707%26rft_id%253Dinfo%253Apmid%252F26845595%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.5604/16652681.1193707&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26845595&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-50-1" title="View reference 50 in text" id="ref-50">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.50" data-doi="10.1016/j.cgh.2012.09.007"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mancebo</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">González-Diéguez</span> <span class="cit-name-given-names">ML</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cadahía</span> <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Annual incidence of hepatocellular carcinoma among patients with alcoholic cirrhosis and identification of risk groups</span>. <abbr class="cit-jnl-abbrev">Clin Gastroenterol Hepatol</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">11</span>:<span class="cit-fpage">95</span>-<span class="cit-lpage">101</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.cgh.2012.09.007</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22982095</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClin%2BGastroenterol%2BHepatol%26rft.volume%253D11%26rft.spage%253D95%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.cgh.2012.09.007%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.cgh.2012.09.007&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-51-1" title="View reference 51 in text" id="ref-51">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.51" data-doi="10.1016/j.jhep.2018.07.022"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ganne-Carrié</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chaffaut</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bourcier</span> <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">for CIRRAL Group</span></li></ol><cite>. <span class="cit-article-title">Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">69</span>:<span class="cit-fpage">1274</span>-<span class="cit-lpage">83</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2018.07.022</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30092234</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D69%26rft.spage%253D1274%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2018.07.022%26rft_id%253Dinfo%253Apmid%252F30092234%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2018.07.022&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30092234&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-52-1" title="View reference 52 in text" id="ref-52">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.52" data-doi="10.1016/j.jhep.2019.05.008"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Ioannou</span> <span class="cit-name-given-names">GN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Green</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kerr</span> <span class="cit-name-given-names">KF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Berry</span> <span class="cit-name-given-names">K</span></span></li></ol><cite>. <span class="cit-article-title">Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">71</span>:<span class="cit-fpage">523</span>-<span class="cit-lpage">33</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2019.05.008</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31145929</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D71%26rft.spage%253D523%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2019.05.008%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2019.05.008&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-53-1" title="View reference 53 in text" id="ref-53">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.53" data-doi="10.1038/s41598-022-05196-w"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lee</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Choi</span> <span class="cit-name-given-names">GH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jang</span> <span class="cit-name-given-names">ES</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jeong</span> <span class="cit-name-given-names">SH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span> <span class="cit-name-given-names">JW</span></span></li></ol><cite>. <span class="cit-article-title">A scoring system for predicting hepatocellular carcinoma risk in alcoholic cirrhosis</span>. <abbr class="cit-jnl-abbrev">Sci Rep</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">12</span>:<span class="cit-fpage">1717</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41598-022-05196-w</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35110551</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DSci%2BRep%26rft.volume%253D12%26rft.spage%253D1717%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41598-022-05196-w%26rft_id%253Dinfo%253Apmid%252F35110551%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41598-022-05196-w&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35110551&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-54-1" title="View reference 54 in text" id="ref-54">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.54" data-doi="10.1016/j.jhep.2010.07.016"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Sandahl</span> <span class="cit-name-given-names">TD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jepsen</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thomsen</span> <span class="cit-name-given-names">KL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Vilstrup</span> <span class="cit-name-given-names">H</span></span></li></ol><cite>. <span class="cit-article-title">Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2011</span>;<span class="cit-vol">54</span>:<span class="cit-fpage">760</span>-<span class="cit-lpage">4</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2010.07.016</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21126790</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D54%26rft.spage%253D760%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2010.07.016%26rft_id%253Dinfo%253Apmid%252F21126790%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2010.07.016&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21126790&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000288831400022&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-55-1" title="View reference 55 in text" id="ref-55">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.55" data-doi="10.1111/jgh.14513"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lee</span> <span class="cit-name-given-names">JY</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cho</span> <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hong</span> <span class="cit-name-given-names">MH</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Incidence, inhospital mortality, and readmission among patients with alcoholic hepatitis in Korea: A nationwide study</span>. <abbr class="cit-jnl-abbrev">J Gastroenterol Hepatol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">747</span>-<span class="cit-lpage">54</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/jgh.14513</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30345539</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BGastroenterol%2BHepatol%26rft.volume%253D34%26rft.spage%253D747%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjgh.14513%26rft_id%253Dinfo%253Apmid%252F30345539%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/jgh.14513&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30345539&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-56-1" title="View reference 56 in text" id="ref-56">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.56" data-doi="10.1097/MCG.0000000000001378"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Shirazi</span> <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Singal</span> <span class="cit-name-given-names">AK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wong</span> <span class="cit-name-given-names">RJ</span></span></li></ol><cite>. <span class="cit-article-title">Alcohol-associated cirrhosis and alcoholic hepatitis hospitalization trends in the United States</span>. <abbr class="cit-jnl-abbrev">J Clin Gastroenterol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">55</span>:<span class="cit-fpage">174</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1097/MCG.0000000000001378</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32520887</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BClin%2BGastroenterol%26rft.volume%253D55%26rft.spage%253D174%26rft_id%253Dinfo%253Adoi%252F10.1097%252FMCG.0000000000001378%26rft_id%253Dinfo%253Apmid%252F32520887%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1097/MCG.0000000000001378&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32520887&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-57-1" title="View reference 57 in text" id="ref-57">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.57" data-doi="10.1007/s10620-020-06346-8"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Doshi</span> <span class="cit-name-given-names">SD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stotts</span> <span class="cit-name-given-names">MJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hubbard</span> <span class="cit-name-given-names">RA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Goldberg</span> <span class="cit-name-given-names">DS</span></span></li></ol><cite>. <span class="cit-article-title">The changing burden of alcoholic hepatitis: rising incidence and associations with age, gender, race, and geography</span>. <abbr class="cit-jnl-abbrev">Dig Dis Sci</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">66</span>:<span class="cit-fpage">1707</span>-<span class="cit-lpage">14</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s10620-020-06346-8</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32436122</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DDig%2BDis%2BSci%26rft.volume%253D66%26rft.spage%253D1707%26rft_id%253Dinfo%253Adoi%252F10.1007%252Fs10620-020-06346-8%26rft_id%253Dinfo%253Apmid%252F32436122%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1007/s10620-020-06346-8&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32436122&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-58-1" title="View reference 58 in text" id="ref-58">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.58" data-doi="10.1056/NEJMoa1101214"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Nguyen-Khac</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thevenot</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Piquet</span> <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">AAH-NAC Study Group</span></li></ol><cite>. <span class="cit-article-title">Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr><span class="cit-pub-date">2011</span>;<span class="cit-vol">365</span>:<span class="cit-fpage">1781</span>-<span class="cit-lpage">9</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMoa1101214</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22070475</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DNguyen-Khac%26rft.auinit1%253DE.%26rft.volume%253D365%26rft.issue%253D19%26rft.spage%253D1781%26rft.epage%253D1789%26rft.atitle%253DGlucocorticoids%2Bplus%2BN-acetylcysteine%2Bin%2Bsevere%2Balcoholic%2Bhepatitis.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1101214%26rft_id%253Dinfo%253Apmid%252F22070475%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1056/NEJMoa1101214&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22070475&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000296762800007&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-59-1" title="View reference 59 in text" id="ref-59">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.59" data-doi="10.1056/NEJMoa1412278"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Thursz</span> <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Richardson</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Allison</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">STOPAH Trial</span></li></ol><cite>. <span class="cit-article-title">Prednisolone or pentoxifylline for alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">372</span>:<span class="cit-fpage">1619</span>-<span class="cit-lpage">28</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMoa1412278</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25901427</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D372%26rft.spage%253D1619%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1412278%26rft_id%253Dinfo%253Apmid%252F25901427%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1056/NEJMoa1412278&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25901427&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-60-1" title="View reference 60 in text" id="ref-60">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.60" data-doi="10.1371/journal.pone.0192393"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Hughes</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hopkins</span> <span class="cit-name-given-names">LJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Parker</span> <span class="cit-name-given-names">R</span></span></li></ol><cite>. <span class="cit-article-title">Survival from alcoholic hepatitis has not improved over time</span>. <abbr class="cit-jnl-abbrev">PLoS One</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">13</span>:<span class="cit-elocation-id">e0192393</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1371/journal.pone.0192393</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29444123</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPLoS%2BOne%26rft.volume%253D13%26rft.spage%253De0192393%26rft_id%253Dinfo%253Adoi%252F10.1371%252Fjournal.pone.0192393%26rft_id%253Dinfo%253Apmid%252F29444123%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1371/journal.pone.0192393&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29444123&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-61-1" title="View reference 61 in text" id="ref-61">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.61" data-doi="10.1038/ng.3417"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Buch</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stickel</span> <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Trépo</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis</span>. <abbr class="cit-jnl-abbrev">Nat Genet</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">47</span>:<span class="cit-fpage">1443</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/ng.3417</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26482880</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNat%2BGenet%26rft.volume%253D47%26rft.spage%253D1443%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fng.3417%26rft_id%253Dinfo%253Apmid%252F26482880%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/ng.3417&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26482880&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-62-1" title="View reference 62 in text" id="ref-62">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.62" data-doi="10.1053/j.gastro.2020.06.014"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Innes</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Buch</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hutchinson</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Genome-wide association study for alcohol-related cirrhosis identifies risk loci in MARC1 and HNRNPUL1</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">159</span>:<span class="cit-fpage">1276</span>-<span class="cit-lpage">1289.e7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2020.06.014</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32561361</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D159%26rft.spage%253D1276%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2020.06.014%26rft_id%253Dinfo%253Apmid%252F32561361%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2020.06.014&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32561361&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-63-1" title="View reference 63 in text" id="ref-63">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.63" data-doi="10.1002/hep.31535"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Schwantes-An</span> <span class="cit-name-given-names">TH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Darlay</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mathurin</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">GenomALC Consortium</span></li></ol><cite>. <span class="cit-article-title">Genome-wide association study and meta-analysis on alcohol-associated liver cirrhosis identifies genetic risk factors</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">73</span>:<span class="cit-fpage">1920</span>-<span class="cit-lpage">31</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.31535</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32853455</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.31535%26rft_id%253Dinfo%253Apmid%252F32853455%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.31535&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32853455&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-64-1" title="View reference 64 in text" id="ref-64">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.64" data-doi="10.1038/ajg.2013.476"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Singal</span> <span class="cit-name-given-names">AG</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Manjunath</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yopp</span> <span class="cit-name-given-names">AC</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis</span>. <abbr class="cit-jnl-abbrev">Am J Gastroenterol</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">109</span>:<span class="cit-fpage">325</span>-<span class="cit-lpage">34</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/ajg.2013.476</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24445574</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAm%2BJ%2BGastroenterol%26rft.volume%253D109%26rft.spage%253D325%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fajg.2013.476%26rft_id%253Dinfo%253Apmid%252F24445574%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/ajg.2013.476&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24445574&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-65-1" title="View reference 65 in text" id="ref-65">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.65" data-doi="10.1016/j.jhep.2017.01.018"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Atkinson</span> <span class="cit-name-given-names">SR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Way</span> <span class="cit-name-given-names">MJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McQuillin</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morgan</span> <span class="cit-name-given-names">MY</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thursz</span> <span class="cit-name-given-names">MR</span></span></li></ol><cite>. <span class="cit-article-title">Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">120</span>-<span class="cit-lpage">7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2017.01.018</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28161471</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D67%26rft.spage%253D120%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2017.01.018%26rft_id%253Dinfo%253Apmid%252F28161471%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2017.01.018&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28161471&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-66-1" title="View reference 66 in text" id="ref-66">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.66" data-doi="10.1111/liv.12310"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Burza</span> <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Molinaro</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Attilia</span> <span class="cit-name-given-names">ML</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis</span>. <abbr class="cit-jnl-abbrev">Liver Int</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">34</span>:<span class="cit-fpage">514</span>-<span class="cit-lpage">20</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/liv.12310</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24102786</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLiver%2BInt%26rft.volume%253D34%26rft.spage%253D514%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fliv.12310%26rft_id%253Dinfo%253Apmid%252F24102786%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/liv.12310&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24102786&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-67-1" title="View reference 67 in text" id="ref-67">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.67" data-doi="10.1111/jgh.12540"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Friedrich</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Wannhoff</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kattner</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">PNPLA3 in end-stage liver disease: alcohol consumption, hepatocellular carcinoma development, and transplantation-free survival</span>. <abbr class="cit-jnl-abbrev">J Gastroenterol Hepatol</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">29</span>:<span class="cit-fpage">1477</span>-<span class="cit-lpage">84</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/jgh.12540</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25273282</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BGastroenterol%2BHepatol%26rft.volume%253D29%26rft.spage%253D1477%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjgh.12540%26rft_id%253Dinfo%253Apmid%252F25273282%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/jgh.12540&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25273282&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-68-1" title="View reference 68 in text" id="ref-68">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.68" data-doi="10.1371/journal.pone.0075982"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Valenti</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Motta</span> <span class="cit-name-given-names">BM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Soardo</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">PNPLA3 I148M polymorphism, clinical presentation, and survival in patients with hepatocellular carcinoma</span>. <abbr class="cit-jnl-abbrev">PLoS One</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">8</span>:<span class="cit-elocation-id">e75982</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1371/journal.pone.0075982</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24155878</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPLoS%2BOne%26rft.volume%253D8%26rft.spage%253De75982%26rft_id%253Dinfo%253Adoi%252F10.1371%252Fjournal.pone.0075982%26rft_id%253Dinfo%253Apmid%252F24155878%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1371/journal.pone.0075982&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24155878&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-69-1" title="View reference 69 in text" id="ref-69">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.69" data-doi="10.1016/S1470-2045(21)00603-3"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Trépo</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Caruso</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yang</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">GENTHEP Consortium</span></li></ol><cite>. <span class="cit-article-title">Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study</span>. <abbr class="cit-jnl-abbrev">Lancet Oncol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">23</span>:<span class="cit-fpage">161</span>-<span class="cit-lpage">71</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S1470-2045(21)00603-3</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34902334</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BOncol%26rft.volume%253D23%26rft.spage%253D161%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS1470-2045%252821%252900603-3%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S1470-2045(21)00603-3&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-70-1" title="View reference 70 in text" id="ref-70">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.70" data-doi="10.1136/gutjnl-2022-327196"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Buch</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Innes</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lutz</span> <span class="cit-name-given-names">PL</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Genetic variation in <em>TERT</em> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study</span>. <abbr class="cit-jnl-abbrev">Gut</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">72</span>:<span class="cit-fpage">381</span>-<span class="cit-lpage">91</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/gutjnl-2022-327196</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35788059</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgutjnl-2022-327196%26rft_id%253Dinfo%253Apmid%252F35788059%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NjoiZ3V0am5sIjtzOjU6InJlc2lkIjtzOjg6IjcyLzIvMzgxIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-71-1" title="View reference 71 in text" id="ref-71">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.71" data-doi="10.1111/add.13081"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Otete</span> <span class="cit-name-given-names">HE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Orton</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">West</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fleming</span> <span class="cit-name-given-names">KM</span></span></li></ol><cite>. <span class="cit-article-title">Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis</span>. <abbr class="cit-jnl-abbrev">Addiction</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">110</span>:<span class="cit-fpage">1932</span>-<span class="cit-lpage">40</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/add.13081</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26235801</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddiction%26rft.volume%253D110%26rft.spage%253D1932%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fadd.13081%26rft_id%253Dinfo%253Apmid%252F26235801%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/add.13081&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26235801&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-72-1" title="View reference 72 in text" id="ref-72">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.72" data-doi="10.1038/s41395-018-0282-6"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Askgaard</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kjær</span> <span class="cit-name-given-names">MS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tolstrup</span> <span class="cit-name-given-names">JS</span></span></li></ol><cite>. <span class="cit-article-title">Opportunities to prevent alcoholic liver cirrhosis in high-risk populations: a systematic review with meta-analysis</span>. <abbr class="cit-jnl-abbrev">Am J Gastroenterol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">114</span>:<span class="cit-fpage">221</span>-<span class="cit-lpage">32</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41395-018-0282-6</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30353053</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAm%2BJ%2BGastroenterol%26rft.volume%253D114%26rft.spage%253D221%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41395-018-0282-6%26rft_id%253Dinfo%253Apmid%252F30353053%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41395-018-0282-6&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30353053&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-73-1" title="View reference 73 in text" id="ref-73">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.73" data-doi="10.1002/hep.28943"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Askgaard</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leon</span> <span class="cit-name-given-names">DA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kjaer</span> <span class="cit-name-given-names">MS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Deleuran</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gerds</span> <span class="cit-name-given-names">TA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tolstrup</span> <span class="cit-name-given-names">JS</span></span></li></ol><cite>. <span class="cit-article-title">Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">65</span>:<span class="cit-fpage">929</span>-<span class="cit-lpage">37</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.28943</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27862159</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D65%26rft.spage%253D929%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.28943%26rft_id%253Dinfo%253Apmid%252F27862159%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.28943&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27862159&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-74-1" title="View reference 74 in text" id="ref-74">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.74" data-doi="10.1177/1403494818763436"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Askgaard</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tolstrup</span> <span class="cit-name-given-names">JS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kjær</span> <span class="cit-name-given-names">MS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leon</span> <span class="cit-name-given-names">DA</span></span></li></ol><cite>. <span class="cit-article-title">Number of hospital contacts with alcohol problems predicts later risk of alcoholic liver cirrhosis</span>. <abbr class="cit-jnl-abbrev">Scand J Public Health</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">47</span>:<span class="cit-fpage">417</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1177/1403494818763436</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29528775</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DScand%2BJ%2BPublic%2BHealth%26rft.volume%253D47%26rft.spage%253D417%26rft_id%253Dinfo%253Adoi%252F10.1177%252F1403494818763436%26rft_id%253Dinfo%253Apmid%252F29528775%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1177/1403494818763436&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29528775&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-75-1" title="View reference 75 in text" id="ref-75">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.75" data-doi="10.1186/s12889-015-1860-9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Cook</span> <span class="cit-name-given-names">PA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morleo</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Billington</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study</span>. <abbr class="cit-jnl-abbrev">BMC Public Health</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">15</span>:<span class="cit-fpage">532</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/s12889-015-1860-9</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26041363</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBMC%2BPublic%2BHealth%26rft.volume%253D15%26rft.spage%253D532%26rft_id%253Dinfo%253Adoi%252F10.1186%252Fs12889-015-1860-9%26rft_id%253Dinfo%253Apmid%252F26041363%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1186/s12889-015-1860-9&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26041363&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-76-1" title="View reference 76 in text" id="ref-76">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.76" data-doi="10.1111/j.1478-3231.2008.01691.x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Myers</span> <span class="cit-name-given-names">RP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fong</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shaheen</span> <span class="cit-name-given-names">AA</span></span></li></ol><cite>. <span class="cit-article-title">Utilization rates, complications and costs of percutaneous liver biopsy: a population-based study including 4275 biopsies</span>. <abbr class="cit-jnl-abbrev">Liver Int</abbr><span class="cit-pub-date">2008</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">705</span>-<span class="cit-lpage">12</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1478-3231.2008.01691.x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18433397</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLiver%2Binternational%2B%253A%2B%2Bofficial%2Bjournal%2Bof%2Bthe%2BInternational%2BAssociation%2Bfor%2Bthe%2BStudy%2Bof%2Bthe%2BLiver%26rft.stitle%253DLiver%2BInt%26rft.aulast%253DMyers%26rft.auinit1%253DR.%2BP.%26rft.volume%253D28%26rft.issue%253D5%26rft.spage%253D705%26rft.epage%253D712%26rft.atitle%253DUtilization%2Brates%252C%2Bcomplications%2Band%2Bcosts%2Bof%2Bpercutaneous%2Bliver%2Bbiopsy%253A%2Ba%2Bpopulation-based%2Bstudy%2Bincluding%2B4275%2Bbiopsies.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1478-3231.2008.01691.x%26rft_id%253Dinfo%253Apmid%252F18433397%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/j.1478-3231.2008.01691.x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18433397&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000254859000018&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-77-1" title="View reference 77 in text" id="ref-77">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.77" data-doi="10.1007/s10620-021-07089-w"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Thomaides-Brears</span> <span class="cit-name-given-names">HB</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Alkhouri</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Allende</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Incidence of complications from percutaneous biopsy in chronic liver disease: a systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">Dig Dis Sci</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">3366</span>-<span class="cit-lpage">94</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s10620-021-07089-w</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34129125</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DDig%2BDis%2BSci%26rft.volume%253D67%26rft.spage%253D3366%26rft_id%253Dinfo%253Adoi%252F10.1007%252Fs10620-021-07089-w%26rft_id%253Dinfo%253Apmid%252F34129125%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1007/s10620-021-07089-w&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34129125&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-78-1" title="View reference 78 in text" id="ref-78">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.78" data-doi="10.1016/j.jhep.2009.05.023"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Schwenzer</span> <span class="cit-name-given-names">NF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Springer</span> <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schraml</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stefan</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Machann</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schick</span> <span class="cit-name-given-names">F</span></span></li></ol><cite>. <span class="cit-article-title">Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2009</span>;<span class="cit-vol">51</span>:<span class="cit-fpage">433</span>-<span class="cit-lpage">45</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2009.05.023</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19604596</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D51%26rft.spage%253D433%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2009.05.023%26rft_id%253Dinfo%253Apmid%252F19604596%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2009.05.023&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19604596&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000269735300005&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-79-1" title="View reference 79 in text" id="ref-79">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.79" data-doi="10.1002/14651858.CD011602.pub2"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Pavlov</span> <span class="cit-name-given-names">CS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Casazza</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Semenistaia</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Cochrane Database Syst Rev</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">3</span>:<span class="cit-elocation-id">CD011602</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/14651858.CD011602.pub2</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26934429</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DCochrane%2BDatabase%2BSyst%2BRev%26rft.volume%253D3%26rft.spage%253DCD011602%26rft_id%253Dinfo%253Adoi%252F10.1002%252F14651858.CD011602.pub2%26rft_id%253Dinfo%253Apmid%252F26934429%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/14651858.CD011602.pub2&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26934429&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-80-1" title="View reference 80 in text" id="ref-80">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.80" data-doi="10.1053/j.gastro.2018.01.005"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Madsen</span> <span class="cit-name-given-names">BS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hansen</span> <span class="cit-name-given-names">JF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Detlefsen</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Antonsen</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Krag</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Accuracy of the enhanced liver fibrosis test vs FibroTest, elastography, and indirect markers in detection of advanced fibrosis in patients with alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">154</span>:<span class="cit-fpage">1369</span>-<span class="cit-lpage">79</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2018.01.005</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29317276</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D154%26rft.spage%253D1369%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2018.01.005%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2018.01.005&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-81-1" title="View reference 81 in text" id="ref-81">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.81" data-doi="10.1186/s12876-021-01795-5"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Connoley</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Patel</span> <span class="cit-name-given-names">PJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hogan</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">The enhanced liver fibrosis test maintains its diagnostic and prognostic performance in alcohol-related liver disease: a cohort study</span>. <abbr class="cit-jnl-abbrev">BMC Gastroenterol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">21</span>:<span class="cit-fpage">268</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/s12876-021-01795-5</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34182924</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBMC%2BGastroenterol%26rft.volume%253D21%26rft.spage%253D268%26rft_id%253Dinfo%253Adoi%252F10.1186%252Fs12876-021-01795-5%26rft_id%253Dinfo%253Apmid%252F34182924%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1186/s12876-021-01795-5&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34182924&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-82-1" title="View reference 82 in text" id="ref-82">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.82" data-doi="10.1016/j.cgh.2021.02.021"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Legros</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bardou-Jacquet</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Turlin</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Transient elastography accurately screens for compensated advanced chronic liver disease in patients with ongoing or recent alcohol withdrawal</span>. <abbr class="cit-jnl-abbrev">Clin Gastroenterol Hepatol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">20</span>:<span class="cit-fpage">1542</span>-<span class="cit-lpage">1552.e6</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.cgh.2021.02.021</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33588101</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClin%2BGastroenterol%2BHepatol%26rft.volume%253D20%26rft.spage%253D1542%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.cgh.2021.02.021%26rft_id%253Dinfo%253Apmid%252F33588101%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.cgh.2021.02.021&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33588101&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-83-1" title="View reference 83 in text" id="ref-83">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.83" data-doi="10.1002/14651858.CD010542.pub2"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Pavlov</span> <span class="cit-name-given-names">CS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Casazza</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nikolova</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Cochrane Database Syst Rev</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">1</span>:<span class="cit-elocation-id">CD010542</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/14651858.CD010542.pub2</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>25612182</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DCochrane%2BDatabase%2BSyst%2BRev%26rft.volume%253D1%26rft.spage%253DCD010542%26rft_id%253Dinfo%253Adoi%252F10.1002%252F14651858.CD010542.pub2%26rft_id%253Dinfo%253Apmid%252F25612182%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/14651858.CD010542.pub2&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=25612182&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-84-1" title="View reference 84 in text" id="ref-84">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.84" data-doi="10.1016/S2468-1253(18)30124-9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Nguyen-Khac</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Voican</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Non-invasive diagnosis of liver fibrosis in patients with alcohol-related liver disease by transient elastography: an individual patient data meta-analysis</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">3</span>:<span class="cit-fpage">614</span>-<span class="cit-lpage">25</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(18)30124-9</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29983372</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D3%26rft.spage%253D614%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252818%252930124-9%26rft_id%253Dinfo%253Apmid%252F29983372%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(18)30124-9&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29983372&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-85-1" title="View reference 85 in text" id="ref-85">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.85" data-doi="10.1002/hep.29179"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Herrmann</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">de Lédinghen</span> <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cassinotto</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">67</span>:<span class="cit-fpage">260</span>-<span class="cit-lpage">72</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.29179</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28370257</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D67%26rft.spage%253D260%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.29179%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.29179&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-86-1" title="View reference 86 in text" id="ref-86">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.86" data-doi="10.3748/wjg.v16.i8.966"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mueller</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Millonig</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sarovska</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis</span>. <abbr class="cit-jnl-abbrev">World J Gastroenterol</abbr><span class="cit-pub-date">2010</span>;<span class="cit-vol">16</span>:<span class="cit-fpage">966</span>-<span class="cit-lpage">72</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3748/wjg.v16.i8.966</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>20180235</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DWorld%2Bjournal%2Bof%2Bgastroenterology%2B%253A%2B%2BWJG%26rft.stitle%253DWorld%2BJ%2BGastroenterol%26rft.aulast%253DMueller%26rft.auinit1%253DS.%26rft.volume%253D16%26rft.issue%253D8%26rft.spage%253D966%26rft.epage%253D972%26rft.atitle%253DIncreased%2Bliver%2Bstiffness%2Bin%2Balcoholic%2Bliver%2Bdisease%253A%2Bdifferentiating%2Bfibrosis%2Bfrom%2Bsteatohepatitis.%26rft_id%253Dinfo%253Adoi%252F10.3748%252Fwjg.v16.i8.966%26rft_id%253Dinfo%253Apmid%252F20180235%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.3748/wjg.v16.i8.966&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=20180235&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000275156900008&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-87-1" title="View reference 87 in text" id="ref-87">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.87" data-doi="10.1002/hep.30979"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Asphaug</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Krag</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Melberg</span> <span class="cit-name-given-names">HO</span></span></li></ol><cite>. <span class="cit-article-title">Cost-effectiveness of noninvasive screening for alcohol-related liver fibrosis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">71</span>:<span class="cit-fpage">2093</span>-<span class="cit-lpage">104</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.30979</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31595545</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D71%26rft.spage%253D2093%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.30979%26rft_id%253Dinfo%253Apmid%252F31595545%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.30979&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31595545&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-88-1" title="View reference 88 in text" id="ref-88">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.88" data-doi="10.1016/j.jhep.2023.04.002"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kjaergaard</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lindvig</span> <span class="cit-name-given-names">KP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thorhauge</span> <span class="cit-name-given-names">KH</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Using the ELF test, FIB-4 and NAFLD fibrosis score to screen the population for liver disease</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">79</span>:<span class="cit-fpage">277</span>-<span class="cit-lpage">86</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2023.04.002</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>37088311</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D79%26rft.spage%253D277%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2023.04.002%26rft_id%253Dinfo%253Apmid%252F37088311%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2023.04.002&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=37088311&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-89-1" title="View reference 89 in text" id="ref-89">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.89" data-doi="10.1038/s41598-022-06998-8"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Blanes-Vidal</span> <span class="cit-name-given-names">V</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lindvig</span> <span class="cit-name-given-names">KP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nadimi</span> <span class="cit-name-given-names">ES</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Krag</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Artificial intelligence outperforms standard blood-based scores in identifying liver fibrosis patients in primary care</span>. <abbr class="cit-jnl-abbrev">Sci Rep</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">12</span>:<span class="cit-fpage">2914</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41598-022-06998-8</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35190650</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DSci%2BRep%26rft.volume%253D12%26rft.spage%253D2914%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41598-022-06998-8%26rft_id%253Dinfo%253Apmid%252F35190650%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41598-022-06998-8&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35190650&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-90-1" title="View reference 90 in text" id="ref-90">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.90" data-doi="10.1111/jgh.15335"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Rhodes</span> <span class="cit-name-given-names">FA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Trembling</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Panovska-Griffiths</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Systematic review: Investigating the prognostic performance of four non-invasive tests in alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">J Gastroenterol Hepatol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">36</span>:<span class="cit-fpage">1435</span>-<span class="cit-lpage">49</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/jgh.15335</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33171534</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BGastroenterol%2BHepatol%26rft.volume%253D36%26rft.spage%253D1435%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fjgh.15335%26rft_id%253Dinfo%253Apmid%252F33171534%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/jgh.15335&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33171534&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-91-1" title="View reference 91 in text" id="ref-91">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.91" data-doi="10.1016/j.jhep.2021.05.037"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Rasmussen</span> <span class="cit-name-given-names">DN</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Johansen</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">GALAXY</span>, </li><li><span class="cit-auth cit-collab">MicrobLiver consortia</span></li></ol><cite>. <span class="cit-article-title">Prognostic performance of 7 biomarkers compared to liver biopsy in early alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">75</span>:<span class="cit-fpage">1017</span>-<span class="cit-lpage">25</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2021.05.037</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34118335</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D75%26rft.spage%253D1017%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2021.05.037%26rft_id%253Dinfo%253Apmid%252F34118335%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2021.05.037&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34118335&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-92-1" title="View reference 92 in text" id="ref-92">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.92" data-doi="10.1016/j.jhep.2015.05.022"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">de Franchis</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth cit-collab">Baveno VI Faculty</span></li></ol><cite>. <span class="cit-article-title">Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2015</span>;<span class="cit-vol">63</span>:<span class="cit-fpage">743</span>-<span class="cit-lpage">52</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2015.05.022</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26047908</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D63%26rft.spage%253D743%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2015.05.022%26rft_id%253Dinfo%253Apmid%252F26047908%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2015.05.022&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26047908&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-93-1" title="View reference 93 in text" id="ref-93">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.93" data-doi="10.1002/hep.29363"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Augustin</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pons</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Maurice</span> <span class="cit-name-given-names">JB</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">66</span>:<span class="cit-fpage">1980</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.29363</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28696510</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D66%26rft.spage%253D1980%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.29363%26rft_id%253Dinfo%253Apmid%252F28696510%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.29363&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28696510&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-94-1" title="View reference 94 in text" id="ref-94">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.94" data-doi="10.51821/88.2.9553"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Pizzamiglio</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Weicker</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">de Terwangne</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Henrion</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Descamps</span> <span class="cit-name-given-names">OS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">De Vos</span> <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Validation of Baveno VI and Expanded-Baveno VI Criteria for predicting gastroesophageal varices in patients with alcoholic and non-alcoholic fatty liver disease</span>. <abbr class="cit-jnl-abbrev">Acta Gastroenterol Belg</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">85</span>:<span class="cit-fpage">321</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.51821/88.2.9553</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35709776</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DActa%2BGastroenterol%2BBelg%26rft.volume%253D85%26rft.spage%253D321%26rft_id%253Dinfo%253Adoi%252F10.51821%252F88.2.9553%26rft_id%253Dinfo%253Apmid%252F35709776%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.51821/88.2.9553&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35709776&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-95-1" title="View reference 95 in text" id="ref-95">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.95" data-doi="10.1016/j.jhep.2021.12.022"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">de Franchis</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bosch</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Garcia-Tsao</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Reiberger</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ripoll</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth cit-collab">Baveno VII Faculty</span></li></ol><cite>. <span class="cit-article-title">Baveno VII - Renewing consensus in portal hypertension</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">959</span>-<span class="cit-lpage">74</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2021.12.022</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35120736</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2021.12.022%26rft_id%253Dinfo%253Apmid%252F35120736%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2021.12.022&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35120736&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-96-1" title="View reference 96 in text" id="ref-96">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.96" data-doi="10.1038/s41591-022-01850-y"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Niu</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thiele</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Geyer</span> <span class="cit-name-given-names">PE</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Noninvasive proteomic biomarkers for alcohol-related liver disease</span>. <abbr class="cit-jnl-abbrev">Nat Med</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">1277</span>-<span class="cit-lpage">87</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41591-022-01850-y</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35654907</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNat%2BMed%26rft.volume%253D28%26rft.spage%253D1277%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41591-022-01850-y%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41591-022-01850-y&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-97-1" title="View reference 97 in text" id="ref-97">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.97"><div class="cit-metadata unstructured">World Health Organization. <em>International Classification of Diseases 11th revision (ICD-11)</em>. 2018 <a href="https://icd.who.int/browse11/l-m/en">https://icd.who.int/browse11/l-m/en</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-98-1" title="View reference 98 in text" id="ref-98">↵</a><div class="cit ref-cit ref-book" id="cit-383.nov20_5.e077090.98"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth cit-collab">American Psychiatric Association</span></li></ol><cite>. <span class="cit-source">Diagnostic and Statistical Manual of Mental Disorders (DSM-5)</span>. APA, <span class="cit-pub-date">2013</span>.</cite></div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-99-1" title="View reference 99 in text" id="ref-99">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.99" data-doi="10.1093/bmb/ldq032"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lingford-Hughes</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Watson</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kalk</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Reid</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Neuropharmacology of addiction and how it informs treatment</span>. <abbr class="cit-jnl-abbrev">Br Med Bull</abbr><span class="cit-pub-date">2010</span>;<span class="cit-vol">96</span>:<span class="cit-fpage">93</span>-<span class="cit-lpage">110</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/bmb/ldq032</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21044987</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBr%2BMed%2BBull%26rft_id%253Dinfo%253Adoi%252F10.1093%252Fbmb%252Fldq032%26rft_id%253Dinfo%253Apmid%252F21044987%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1093/bmb/ldq032&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21044987&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000284637600007&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-100-1" title="View reference 100 in text" id="ref-100">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.100" data-doi="10.1016/S2215-0366(16)00104-8"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Koob</span> <span class="cit-name-given-names">GF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Volkow</span> <span class="cit-name-given-names">ND</span></span></li></ol><cite>. <span class="cit-article-title">Neurobiology of addiction: a neurocircuitry analysis</span>. <abbr class="cit-jnl-abbrev">Lancet Psychiatry</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">3</span>:<span class="cit-fpage">760</span>-<span class="cit-lpage">73</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2215-0366(16)00104-8</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27475769</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BPsychiatry%26rft.volume%253D3%26rft.spage%253D760%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2215-0366%252816%252900104-8%26rft_id%253Dinfo%253Apmid%252F27475769%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2215-0366(16)00104-8&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=27475769&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-101-1" title="View reference 101 in text" id="ref-101">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.101" data-doi="10.1007/s002130050169"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Herz</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Endogenous opioid systems and alcohol addiction</span>. <abbr class="cit-jnl-abbrev">Psychopharmacology (Berl)</abbr><span class="cit-pub-date">1997</span>;<span class="cit-vol">129</span>:<span class="cit-fpage">99</span>-<span class="cit-lpage">111</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1007/s002130050169</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9040115</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPsychopharmacologia%26rft.stitle%253DPsychopharmacologia%26rft.aulast%253DHerz%26rft.auinit1%253DA.%26rft.volume%253D129%26rft.issue%253D2%26rft.spage%253D99%26rft.epage%253D111%26rft.atitle%253DEndogenous%2Bopioid%2Bsystems%2Band%2Balcohol%2Baddiction.%26rft_id%253Dinfo%253Adoi%252F10.1007%252Fs002130050169%26rft_id%253Dinfo%253Apmid%252F9040115%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1007/s002130050169&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=9040115&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-102-1" title="View reference 102 in text" id="ref-102">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.102" data-doi="10.1016/j.biopsych.2014.04.017"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Trifilieff</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Martinez</span> <span class="cit-name-given-names">D</span></span></li></ol><cite>. <span class="cit-article-title">Blunted dopamine release as a biomarker for vulnerability for substance use disorders</span>. <abbr class="cit-jnl-abbrev">Biol Psychiatry</abbr><span class="cit-pub-date">2014</span>;<span class="cit-vol">76</span>:<span class="cit-fpage">4</span>-<span class="cit-lpage">5</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.biopsych.2014.04.017</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>24925889</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBiol%2BPsychiatry%26rft.volume%253D76%26rft.spage%253D4%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.biopsych.2014.04.017%26rft_id%253Dinfo%253Apmid%252F24925889%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.biopsych.2014.04.017&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=24925889&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-103-1" title="View reference 103 in text" id="ref-103">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.103" data-doi="10.1038/s41380-018-0107-4"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Turton</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Myers</span> <span class="cit-name-given-names">JF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mick</span> <span class="cit-name-given-names">I</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals</span>. <abbr class="cit-jnl-abbrev">Mol Psychiatry</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">25</span>:<span class="cit-fpage">1749</span>-<span class="cit-lpage">58</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41380-018-0107-4</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29942043</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DMol%2BPsychiatry%26rft.volume%253D25%26rft.spage%253D1749%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41380-018-0107-4%26rft_id%253Dinfo%253Apmid%252F29942043%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41380-018-0107-4&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29942043&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-104-1" title="View reference 104 in text" id="ref-104">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.104" data-doi="10.1111/j.1369-1600.2012.00464.x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Schacht</span> <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Anton</span> <span class="cit-name-given-names">RF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Myrick</span> <span class="cit-name-given-names">H</span></span></li></ol><cite>. <span class="cit-article-title">Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review</span>. <abbr class="cit-jnl-abbrev">Addict Biol</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">18</span>:<span class="cit-fpage">121</span>-<span class="cit-lpage">33</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1369-1600.2012.00464.x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22574861</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddict%2BBiol%26rft.volume%253D18%26rft.spage%253D121%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1369-1600.2012.00464.x%26rft_id%253Dinfo%253Apmid%252F22574861%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/j.1369-1600.2012.00464.x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22574861&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-105-1" title="View reference 105 in text" id="ref-105">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.105" data-doi="10.1016/j.neubiorev.2013.02.002"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Sescousse</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Caldú</span> <span class="cit-name-given-names">X</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Segura</span> <span class="cit-name-given-names">B</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dreher</span> <span class="cit-name-given-names">JC</span></span></li></ol><cite>. <span class="cit-article-title">Processing of primary and secondary rewards: a quantitative meta-analysis and review of human functional neuroimaging studies</span>. <abbr class="cit-jnl-abbrev">Neurosci Biobehav Rev</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">681</span>-<span class="cit-lpage">96</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neubiorev.2013.02.002</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23415703</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNeuroscience%2Band%2Bbiobehavioral%2Breviews%26rft.stitle%253DNeurosci%2BBiobehav%2BRev%26rft.aulast%253DSescousse%26rft.auinit1%253DG.%26rft.volume%253D37%26rft.spage%253D681%26rft.atitle%253DProcessing%2Bof%2Bprimary%2Band%2Bsecondary%2Brewards%253A%2BA%2Bquantitative%2Bmeta-analysis%2Band%2Breview%2Bof%2Bhuman%2Bfunctional%2Bneuroimaging%2Bstudies.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.neubiorev.2013.02.002%26rft_id%253Dinfo%253Apmid%252F23415703%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.neubiorev.2013.02.002&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23415703&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-106-1" title="View reference 106 in text" id="ref-106">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.106" data-doi="10.1038/npp.2017.99"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Murphy</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nestor</span> <span class="cit-name-given-names">LJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">McGonigle</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">ICCAM Platform</span></li></ol><cite>. <span class="cit-article-title">Acute D3 antagonist GSK598809 selectively enhances neural response during monetary reward anticipation in drug and alcohol dependence</span>. <abbr class="cit-jnl-abbrev">Neuropsychopharmacology</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">42</span>:<span class="cit-fpage">1925</span>-<span class="cit-lpage">6</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/npp.2017.99</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28701746</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNeuropsychopharmacology%26rft.volume%253D42%26rft.spage%253D1925%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fnpp.2017.99%26rft_id%253Dinfo%253Apmid%252F28701746%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/npp.2017.99&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28701746&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-107-1" title="View reference 107 in text" id="ref-107">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.107" data-doi="10.1016/j.neubiorev.2021.06.031"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Zeng</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yu</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cao</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Su</span> <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Dong</span> <span class="cit-name-given-names">Z</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yang</span> <span class="cit-name-given-names">X</span></span></li></ol><cite>. <span class="cit-article-title">Neurobiological correlates of cue-reactivity in alcohol-use disorders: A voxel-wise meta-analysis of fMRI studies</span>. <abbr class="cit-jnl-abbrev">Neurosci Biobehav Rev</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">128</span>:<span class="cit-fpage">294</span>-<span class="cit-lpage">310</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.neubiorev.2021.06.031</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34171325</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNeurosci%2BBiobehav%2BRev%26rft.volume%253D128%26rft.spage%253D294%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.neubiorev.2021.06.031%26rft_id%253Dinfo%253Apmid%252F34171325%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.neubiorev.2021.06.031&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34171325&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-108-1" title="View reference 108 in text" id="ref-108">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.108" data-doi="10.1111/adb.12314"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Courtney</span> <span class="cit-name-given-names">KE</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Schacht</span> <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Hutchison</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Roche</span> <span class="cit-name-given-names">DJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ray</span> <span class="cit-name-given-names">LA</span></span></li></ol><cite>. <span class="cit-article-title">Neural substrates of cue reactivity: association with treatment outcomes and relapse</span>. <abbr class="cit-jnl-abbrev">Addict Biol</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">21</span>:<span class="cit-fpage">3</span>-<span class="cit-lpage">22</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/adb.12314</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26435524</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddict%2BBiol%26rft.volume%253D21%26rft.spage%253D3%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fadb.12314%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/adb.12314&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-109-1" title="View reference 109 in text" id="ref-109">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.109" data-doi="10.1124/pharmrev.120.000083"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Koob</span> <span class="cit-name-given-names">GF</span></span></li></ol><cite>. <span class="cit-article-title">Drug addiction: Hyperkatifeia/negative reinforcement as a framework for medications development</span>. <abbr class="cit-jnl-abbrev">Pharmacol Rev</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">73</span>:<span class="cit-fpage">163</span>-<span class="cit-lpage">201</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1124/pharmrev.120.000083</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33318153</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DPharmacol%2BRev%26rft.volume%253D73%26rft.spage%253D163%26rft_id%253Dinfo%253Adoi%252F10.1124%252Fpharmrev.120.000083%26rft_id%253Dinfo%253Apmid%252F33318153%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1124/pharmrev.120.000083&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33318153&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-110-1" title="View reference 110 in text" id="ref-110">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.110" data-doi="10.1038/nrneurol.2011.42"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Zahr</span> <span class="cit-name-given-names">NM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kaufman</span> <span class="cit-name-given-names">KL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Harper</span> <span class="cit-name-given-names">CG</span></span></li></ol><cite>. <span class="cit-article-title">Clinical and pathological features of alcohol-related brain damage</span>. <abbr class="cit-jnl-abbrev">Nat Rev Neurol</abbr><span class="cit-pub-date">2011</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">284</span>-<span class="cit-lpage">94</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/nrneurol.2011.42</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>21487421</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.stitle%253DNat%2BRev%2BNeurol%26rft.aulast%253DZahr%26rft.auinit1%253DN.%2BM.%26rft.volume%253D7%26rft.issue%253D5%26rft.spage%253D284%26rft.epage%253D294%26rft.atitle%253DClinical%2Band%2Bpathological%2Bfeatures%2Bof%2Balcohol-related%2Bbrain%2Bdamage.%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fnrneurol.2011.42%26rft_id%253Dinfo%253Apmid%252F21487421%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/nrneurol.2011.42&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21487421&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-111-1" title="View reference 111 in text" id="ref-111">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.111" data-doi="10.3389/fpsyt.2022.863734"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Agarwal</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Manza</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Chapman</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Inflammatory markers in substance use and mood disorders: a neuroimaging perspective</span>. <abbr class="cit-jnl-abbrev">Front Psychiatry</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">13</span>:<span class="cit-elocation-id">863734</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.3389/fpsyt.2022.863734</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35558424</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DFront%2BPsychiatry%26rft.volume%253D13%26rft.spage%253D863734%26rft_id%253Dinfo%253Adoi%252F10.3389%252Ffpsyt.2022.863734%26rft_id%253Dinfo%253Apmid%252F35558424%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.3389/fpsyt.2022.863734&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35558424&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-112-1" title="View reference 112 in text" id="ref-112">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.112" data-doi="10.1016/j.drugalcdep.2022.109319"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Parvaz</span> <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rabin</span> <span class="cit-name-given-names">RA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Adams</span> <span class="cit-name-given-names">F</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Goldstein</span> <span class="cit-name-given-names">RZ</span></span></li></ol><cite>. <span class="cit-article-title">Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies</span>. <abbr class="cit-jnl-abbrev">Drug Alcohol Depend</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">232</span>:<span class="cit-elocation-id">109319</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.drugalcdep.2022.109319</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35077955</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DDrug%2BAlcohol%2BDepend%26rft.volume%253D232%26rft.spage%253D109319%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.drugalcdep.2022.109319%26rft_id%253Dinfo%253Apmid%252F35077955%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.drugalcdep.2022.109319&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35077955&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-113-1" title="View reference 113 in text" id="ref-113">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.113" data-doi="10.1016/j.alcohol.2022.06.002"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Sullivan</span> <span class="cit-name-given-names">EV</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pfefferbaum</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia</span>. <abbr class="cit-jnl-abbrev">Alcohol</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">107</span>:<span class="cit-fpage">44</span>-<span class="cit-lpage">55</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.alcohol.2022.06.002</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35781021</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlcohol%26rft.volume%253D107%26rft.spage%253D44%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.alcohol.2022.06.002%26rft_id%253Dinfo%253Apmid%252F35781021%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.alcohol.2022.06.002&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35781021&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-114-1" title="View reference 114 in text" id="ref-114">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.114"><div class="cit-metadata unstructured">National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis, assessment and management of harmful drinking (high-risk drinking) and alcohol dependence (clinical guideline CG115). 2011. <a href="https://www.nice.org.uk/guidance/cg115">https://www.nice.org.uk/guidance/cg115</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-115-1" title="View reference 115 in text" id="ref-115">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.115" data-doi="10.1111/j.1360-0443.1993.tb00820.x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Bien</span> <span class="cit-name-given-names">TH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Miller</span> <span class="cit-name-given-names">WR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tonigan</span> <span class="cit-name-given-names">JS</span></span></li></ol><cite>. <span class="cit-article-title">Brief interventions for alcohol problems: a review</span>. <abbr class="cit-jnl-abbrev">Addiction</abbr><span class="cit-pub-date">1993</span>;<span class="cit-vol">88</span>:<span class="cit-fpage">315</span>-<span class="cit-lpage">35</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1360-0443.1993.tb00820.x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>8461850</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddiction%2B%2528Abingdon%252C%2BEngland%2529%26rft.stitle%253DAddiction%26rft.aulast%253DBien%26rft.auinit1%253DT.%2BH.%26rft.volume%253D88%26rft.issue%253D3%26rft.spage%253D315%26rft.epage%253D335%26rft.atitle%253DBrief%2Binterventions%2Bfor%2Balcohol%2Bproblems%253A%2Ba%2Breview.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1360-0443.1993.tb00820.x%26rft_id%253Dinfo%253Apmid%252F8461850%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/j.1360-0443.1993.tb00820.x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=8461850&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=A1993KR15200002&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-116-1" title="View reference 116 in text" id="ref-116">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.116" data-doi="10.1002/14651858.CD004148.pub4"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kaner</span> <span class="cit-name-given-names">EF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Beyer</span> <span class="cit-name-given-names">FR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Muirhead</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Effectiveness of brief alcohol interventions in primary care populations</span>. <abbr class="cit-jnl-abbrev">Cochrane Database Syst Rev</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">2</span>:<span class="cit-elocation-id">CD004148</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/14651858.CD004148.pub4</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29476653</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DCochrane%2BDatabase%2BSyst%2BRev%26rft.volume%253D2%26rft.spage%253DCD004148%26rft_id%253Dinfo%253Adoi%252F10.1002%252F14651858.CD004148.pub4%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/14651858.CD004148.pub4&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-117-1" title="View reference 117 in text" id="ref-117">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.117" data-doi="10.1111/acer.12117"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Addolorato</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mirijello</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leggio</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">Gemelli OLT Group</span></li></ol><cite>. <span class="cit-article-title">Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center</span>. <abbr class="cit-jnl-abbrev">Alcohol Clin Exp Res</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">37</span>:<span class="cit-fpage">1601</span>-<span class="cit-lpage">8</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/acer.12117</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23578009</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlcohol%2BClin%2BExp%2BRes%26rft.volume%253D37%26rft.spage%253D1601%26rft_id%253Dinfo%253Adoi%252F10.1111%252Facer.12117%26rft_id%253Dinfo%253Apmid%252F23578009%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/acer.12117&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23578009&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-118-1" title="View reference 118 in text" id="ref-118">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.118" data-doi="10.1002/14651858.CD012880.pub2"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kelly</span> <span class="cit-name-given-names">JF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Humphreys</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ferri</span> <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Alcoholics Anonymous and other 12-step programs for alcohol use disorder</span>. <abbr class="cit-jnl-abbrev">Cochrane Database Syst Rev</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">3</span>:<span class="cit-elocation-id">CD012880</span>.<span class="cit-pub-id-sep cit-pub-id-pmid-sep"> .</span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32159228</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DCochrane%2BDatabase%2BSyst%2BRev%26rft.volume%253D3%26rft.spage%253DCD012880%26rft_id%253Dinfo%253Adoi%252F10.1002%252F14651858.CD012880.pub2%26rft_id%253Dinfo%253Apmid%252F32159228%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/14651858.CD012880.pub2&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32159228&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-119-1" title="View reference 119 in text" id="ref-119">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.119" data-doi="10.1177/0269881112444324"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Lingford-Hughes</span> <span class="cit-name-given-names">AR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Welch</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Peters</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Nutt</span> <span class="cit-name-given-names">DJ</span></span>, </li><li><span class="cit-auth cit-collab">British Association for Psychopharmacology, Expert Reviewers Group</span></li></ol><cite>. <span class="cit-article-title">BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP</span>. <abbr class="cit-jnl-abbrev">J Psychopharmacol</abbr><span class="cit-pub-date">2012</span>;<span class="cit-vol">26</span>:<span class="cit-fpage">899</span>-<span class="cit-lpage">952</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1177/0269881112444324</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22628390</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BPsychopharmacol%26rft_id%253Dinfo%253Adoi%252F10.1177%252F0269881112444324%26rft_id%253Dinfo%253Apmid%252F22628390%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1177/0269881112444324&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22628390&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000305625900001&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-120-1" title="View reference 120 in text" id="ref-120">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.120"><div class="cit-metadata unstructured">National Clinical Guideline Centre. Alcohol use disorders: diagnosis and clinical management of alcohol-related physical complications. 2010. <a href="https://www.nice.org.uk/guidance/cg100/evidence/full-guideline-pdf-134509213">https://www.nice.org.uk/guidance/cg100/evidence/full-guideline-pdf-134509213</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-121-1" title="View reference 121 in text" id="ref-121">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.121" data-doi="10.1136/jnnp.62.1.51"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Caine</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Halliday</span> <span class="cit-name-given-names">GM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kril</span> <span class="cit-name-given-names">JJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Harper</span> <span class="cit-name-given-names">CG</span></span></li></ol><cite>. <span class="cit-article-title">Operational criteria for the classification of chronic alcoholics: identification of Wernicke’s encephalopathy</span>. <abbr class="cit-jnl-abbrev">J Neurol Neurosurg Psychiatry</abbr><span class="cit-pub-date">1997</span>;<span class="cit-vol">62</span>:<span class="cit-fpage">51</span>-<span class="cit-lpage">60</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/jnnp.62.1.51</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>9010400</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJournal%2Bof%2BNeurology%252C%2BNeurosurgery%2B%2526%2BPsychiatry%26rft.stitle%253DJ.%2BNeurol.%2BNeurosurg.%2BPsychiatry%26rft.aulast%253DCaine%26rft.auinit1%253DD%26rft.volume%253D62%26rft.issue%253D1%26rft.spage%253D51%26rft.epage%253D60%26rft.atitle%253DOperational%2Bcriteria%2Bfor%2Bthe%2Bclassification%2Bof%2Bchronic%2Balcoholics%253A%2Bidentification%2Bof%2BWernicke%2527s%2Bencephalopathy.%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fjnnp.62.1.51%26rft_id%253Dinfo%253Apmid%252F9010400%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiam5ucCI7czo1OiJyZXNpZCI7czo3OiI2Mi8xLzUxIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-122-1" title="View reference 122 in text" id="ref-122">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.122" data-doi="10.1093/alcalc/ags111"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Thomson</span> <span class="cit-name-given-names">AD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Marshall</span> <span class="cit-name-given-names">EJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bell</span> <span class="cit-name-given-names">D</span></span></li></ol><cite>. <span class="cit-article-title">Time to act on the inadequate management of Wernicke’s encephalopathy in the UK</span>. <abbr class="cit-jnl-abbrev">Alcohol Alcohol</abbr><span class="cit-pub-date">2013</span>;<span class="cit-vol">48</span>:<span class="cit-fpage">4</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/alcalc/ags111</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>23065147</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlcohol%2BAlcohol%26rft_id%253Dinfo%253Adoi%252F10.1093%252Falcalc%252Fags111%26rft_id%253Dinfo%253Apmid%252F23065147%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1093/alcalc/ags111&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=23065147&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000312652300002&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-123-1" title="View reference 123 in text" id="ref-123">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.123" data-doi="10.1016/S2215-0366(18)30303-1"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Agabio</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sinclair</span> <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Addolorato</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Baclofen for the treatment of alcohol use disorder: the Cagliari Statement</span>. <abbr class="cit-jnl-abbrev">Lancet Psychiatry</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">5</span>:<span class="cit-fpage">957</span>-<span class="cit-lpage">60</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2215-0366(18)30303-1</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30413394</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BPsychiatry%26rft.volume%253D5%26rft.spage%253D957%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2215-0366%252818%252930303-1%26rft_id%253Dinfo%253Apmid%252F30413394%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2215-0366(18)30303-1&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30413394&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-124-1" title="View reference 124 in text" id="ref-124">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.124" data-doi="10.1111/add.14191"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Rose</span> <span class="cit-name-given-names">AK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Jones</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis</span>. <abbr class="cit-jnl-abbrev">Addiction</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">113</span>:<span class="cit-fpage">1396</span>-<span class="cit-lpage">406</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/add.14191</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29479827</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAddiction%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fadd.14191%26rft_id%253Dinfo%253Apmid%252F29479827%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/add.14191&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29479827&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-125-1" title="View reference 125 in text" id="ref-125">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.125" data-doi="10.1016/j.euroneuro.2018.03.017"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Pierce</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sutterland</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Beraha</span> <span class="cit-name-given-names">EM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morley</span> <span class="cit-name-given-names">K</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">van den Brink</span> <span class="cit-name-given-names">W</span></span></li></ol><cite>. <span class="cit-article-title">Efficacy, tolerability, and safety of low-dose and high-dose baclofen in the treatment of alcohol dependence: A systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">Eur Neuropsychopharmacol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">28</span>:<span class="cit-fpage">795</span>-<span class="cit-lpage">806</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.euroneuro.2018.03.017</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29934090</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DEur%2BNeuropsychopharmacol%26rft.volume%253D28%26rft.spage%253D795%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.euroneuro.2018.03.017%26rft_id%253Dinfo%253Apmid%252F29934090%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.euroneuro.2018.03.017&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29934090&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-126-1" title="View reference 126 in text" id="ref-126">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.126" data-doi="10.1111/acps.12905"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Bschor</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Henssler</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Müller</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Baethge</span> <span class="cit-name-given-names">C</span></span></li></ol><cite>. <span class="cit-article-title">Baclofen for alcohol use disorder-a systematic meta-analysis</span>. <abbr class="cit-jnl-abbrev">Acta Psychiatr Scand</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">138</span>:<span class="cit-fpage">232</span>-<span class="cit-lpage">42</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/acps.12905</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29888478</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DActa%2BPsychiatr%2BScand%26rft.volume%253D138%26rft.spage%253D232%26rft_id%253Dinfo%253Adoi%252F10.1111%252Facps.12905%26rft_id%253Dinfo%253Apmid%252F29888478%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/acps.12905&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29888478&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-127-1" title="View reference 127 in text" id="ref-127">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.127"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Minozzi</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Saulle</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rösner</span> <span class="cit-name-given-names">S</span></span></li></ol><cite>. <span class="cit-article-title">Baclofen for alcohol use disorder</span>. <abbr class="cit-jnl-abbrev">Cochrane Database Syst Rev</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">11</span>:<span class="cit-elocation-id">CD012557</span>.<span class="cit-pub-id-sep cit-pub-id-pmid-sep"> .</span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30484285</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DCochrane%2BDatabase%2BSyst%2BRev%26rft.volume%253D11%26rft.spage%253DCD012557%26rft_id%253Dinfo%253Apmid%252F30484285%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=30484285&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-128-1" title="View reference 128 in text" id="ref-128">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.128" data-doi="10.1176/appi.ajp.2017.1750101"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Reus</span> <span class="cit-name-given-names">VI</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fochtmann</span> <span class="cit-name-given-names">LJ</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bukstein</span> <span class="cit-name-given-names">O</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder</span>. <abbr class="cit-jnl-abbrev">Am J Psychiatry</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">175</span>:<span class="cit-fpage">86</span>-<span class="cit-lpage">90</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1176/appi.ajp.2017.1750101</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29301420</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAm%2BJ%2BPsychiatry%26rft.volume%253D175%26rft.spage%253D86%26rft_id%253Dinfo%253Adoi%252F10.1176%252Fappi.ajp.2017.1750101%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1176/appi.ajp.2017.1750101&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-129-1" title="View reference 129 in text" id="ref-129">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.129" data-doi="10.1038/s41575-021-00527-0"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Arab</span> <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Izzy</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leggio</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bataller</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shah</span> <span class="cit-name-given-names">VH</span></span></li></ol><cite>. <span class="cit-article-title">Management of alcohol use disorder in patients with cirrhosis in the setting of liver transplantation</span>. <abbr class="cit-jnl-abbrev">Nat Rev Gastroenterol Hepatol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">19</span>:<span class="cit-fpage">45</span>-<span class="cit-lpage">59</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/s41575-021-00527-0</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34725498</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNat%2BRev%2BGastroenterol%2BHepatol%26rft.volume%253D19%26rft.spage%253D45%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fs41575-021-00527-0%26rft_id%253Dinfo%253Apmid%252F34725498%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1038/s41575-021-00527-0&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34725498&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-130-1" title="View reference 130 in text" id="ref-130">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.130" data-doi="10.1016/S0140-6736(07)61814-5"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Addolorato</span> <span class="cit-name-given-names">G</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leggio</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ferrulli</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study</span>. <abbr class="cit-jnl-abbrev">Lancet</abbr><span class="cit-pub-date">2007</span>;<span class="cit-vol">370</span>:<span class="cit-fpage">1915</span>-<span class="cit-lpage">22</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0140-6736(07)61814-5</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>18068515</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DAddolorato%26rft.auinit1%253DG.%26rft.volume%253D370%26rft.issue%253D9603%26rft.spage%253D1915%26rft.epage%253D1922%26rft.atitle%253DEffectiveness%2Band%2Bsafety%2Bof%2Bbaclofen%2Bfor%2Bmaintenance%2Bof%2Balcohol%2Babstinence%2Bin%2Balcohol-dependent%2Bpatients%2Bwith%2Bliver%2Bcirrhosis%253A%2Brandomised%252C%2Bdouble-blind%2Bcontrolled%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252807%252961814-5%26rft_id%253Dinfo%253Apmid%252F18068515%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S0140-6736(07)61814-5&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=18068515&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000251517600029&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-131-1" title="View reference 131 in text" id="ref-131">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.131"><div class="cit-metadata unstructured">NHS Digital. Statistics on alcohol, England 2021. 2021. <a href="https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-alcohol/2021">https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-alcohol/2021</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-132-1" title="View reference 132 in text" id="ref-132">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.132" data-doi="10.1002/hep.31042"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Rogal</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Youk</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Zhang</span> <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Impact of alcohol use disorder treatment on clinical outcomes among patients with cirrhosis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">71</span>:<span class="cit-fpage">2080</span>-<span class="cit-lpage">92</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.31042</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31758811</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D71%26rft.spage%253D2080%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.31042%26rft_id%253Dinfo%253Apmid%252F31758811%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.31042&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31758811&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-133-1" title="View reference 133 in text" id="ref-133">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.133" data-doi="10.1016/j.cgh.2022.08.001"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Vannier</span> <span class="cit-name-given-names">AGL</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Przybyszewski</span> <span class="cit-name-given-names">EM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shay</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Psychotherapy for alcohol use disorder is associated with reduced risk of incident alcohol-associated liver disease</span>. <abbr class="cit-jnl-abbrev">Clin Gastroenterol Hepatol</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">21</span>:<span class="cit-fpage">1571</span>-<span class="cit-lpage">1580.e7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.cgh.2022.08.001</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35964893</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClin%2BGastroenterol%2BHepatol%26rft.volume%253D21%26rft.spage%253D1571%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.cgh.2022.08.001%26rft_id%253Dinfo%253Apmid%252F35964893%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.cgh.2022.08.001&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35964893&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-134-1" title="View reference 134 in text" id="ref-134">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.134" data-doi="10.1111/apt.13965"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Goh</span> <span class="cit-name-given-names">ET</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Morgan</span> <span class="cit-name-given-names">MY</span></span></li></ol><cite>. <span class="cit-article-title">Review article: pharmacotherapy for alcohol dependence - the why, the what and the wherefore</span>. <abbr class="cit-jnl-abbrev">Aliment Pharmacol Ther</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">45</span>:<span class="cit-fpage">865</span>-<span class="cit-lpage">82</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/apt.13965</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28220511</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAliment%2BPharmacol%2BTher%26rft.volume%253D45%26rft.spage%253D865%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fapt.13965%26rft_id%253Dinfo%253Apmid%252F28220511%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/apt.13965&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28220511&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-135-1" title="View reference 135 in text" id="ref-135">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.135"><div class="cit-metadata unstructured">Public Health England. Developing pathways for referring patients from secondary care to specialist alcohol treatment. 2018. <a href="https://www.gov.uk/government/publications/developing-pathways-for-alcohol-treatment/developing-pathways-for-referring-patients-from-secondary-care-to-specialist-alcohol-treatment">https://www.gov.uk/government/publications/developing-pathways-for-alcohol-treatment/developing-pathways-for-referring-patients-from-secondary-care-to-specialist-alcohol-treatment</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-136-1" title="View reference 136 in text" id="ref-136">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.136" data-doi="10.1016/j.cgh.2015.07.047"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Khan</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Tansel</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">White</span> <span class="cit-name-given-names">DL</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Efficacy of psychosocial interventions in inducing and maintaining alcohol abstinence in patients with chronic liver disease: a systematic review</span>. <abbr class="cit-jnl-abbrev">Clin Gastroenterol Hepatol</abbr><span class="cit-pub-date">2016</span>;<span class="cit-vol">14</span>:<span class="cit-fpage">191</span>-<span class="cit-lpage">202.e1, 4, quiz e20</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.cgh.2015.07.047</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>26256464</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClin%2BGastroenterol%2BHepatol%26rft.volume%253D14%26rft.spage%253D191%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.cgh.2015.07.047%26rft_id%253Dinfo%253Apmid%252F26256464%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.cgh.2015.07.047&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=26256464&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-137-1" title="View reference 137 in text" id="ref-137">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.137" data-doi="10.1016/S2468-1253(21)00191-6"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">DiMartini</span> <span class="cit-name-given-names">AF</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Leggio</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Singal</span> <span class="cit-name-given-names">AK</span></span></li></ol><cite>. <span class="cit-article-title">Barriers to the management of alcohol use disorder and alcohol-associated liver disease: strategies to implement integrated care models</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">186</span>-<span class="cit-lpage">95</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(21)00191-6</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35026172</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D7%26rft.spage%253D186%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252821%252900191-6%26rft_id%253Dinfo%253Apmid%252F35026172%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(21)00191-6&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35026172&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-138-1" title="View reference 138 in text" id="ref-138">↵</a><div class="cit ref-cit ref-web" id="cit-383.nov20_5.e077090.138"><div class="cit-metadata unstructured">Public Health England. Alcohol care team: core service descriptor. 2019. <a href="https://www.longtermplan.nhs.uk/wp-content/uploads/2019/11/ACT-core-service-descriptor-051119.pdf">https://www.longtermplan.nhs.uk/wp-content/uploads/2019/11/ACT-core-service-descriptor-051119.pdf</a>.</div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-139-1" title="View reference 139 in text" id="ref-139">↵</a><div class="cit ref-cit ref-book" id="cit-383.nov20_5.e077090.139"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mohan</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mitchell</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sharp</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-source">Exploring the management of alcohol problems in Deep End practices in Scotland.</span><span class="cit-publ-name">Scottish Health Action on Alcohol Problems</span>, <span class="cit-pub-date">2022</span>.</cite></div><div class="cit-extra"></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-140-1" title="View reference 140 in text" id="ref-140">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.140" data-doi="10.1093/alcalc/agaa086"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Phillips</span> <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Huang</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Roberts</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Drummond</span> <span class="cit-name-given-names">C</span></span></li></ol><cite>. <span class="cit-article-title">Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship</span>. <abbr class="cit-jnl-abbrev">Alcohol Alcohol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">56</span>:<span class="cit-fpage">28</span>-<span class="cit-lpage">33</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1093/alcalc/agaa086</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>32885812</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAlcohol%2BAlcohol%26rft.volume%253D56%26rft.spage%253D28%26rft_id%253Dinfo%253Adoi%252F10.1093%252Falcalc%252Fagaa086%26rft_id%253Dinfo%253Apmid%252F32885812%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1093/alcalc/agaa086&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=32885812&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-141-1" title="View reference 141 in text" id="ref-141">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.141" data-doi="10.1016/S0168-8278(99)80263-3"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mato</span> <span class="cit-name-given-names">JM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Cámara</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Fernández de Paz</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">1999</span>;<span class="cit-vol">30</span>:<span class="cit-fpage">1081</span>-<span class="cit-lpage">9</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S0168-8278(99)80263-3</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>10406187</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJournal%2Bof%2Bhepatology%26rft.stitle%253DJ%2BHepatol%26rft.aulast%253DMato%26rft.auinit1%253DJ.%2BM.%26rft.volume%253D30%26rft.issue%253D6%26rft.spage%253D1081%26rft.epage%253D1089%26rft.atitle%253DS-adenosylmethionine%2Bin%2Balcoholic%2Bliver%2Bcirrhosis%253A%2Ba%2Brandomized%252C%2Bplacebo-controlled%252C%2Bdouble-blind%252C%2Bmulticenter%2Bclinical%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0168-8278%252899%252980263-3%26rft_id%253Dinfo%253Apmid%252F10406187%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S0168-8278(99)80263-3&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=10406187&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000080814700017&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-142-1" title="View reference 142 in text" id="ref-142">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.142" data-doi="10.1016/S2468-1253(23)00010-9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Israelsen</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Madsen</span> <span class="cit-name-given-names">BS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Torp</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">GALAXY</span>, </li><li><span class="cit-auth cit-collab">MicrobLiver Consortia</span></li></ol><cite>. <span class="cit-article-title">Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2023</span>;<span class="cit-vol">8</span>:<span class="cit-fpage">523</span>-<span class="cit-lpage">32</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(23)00010-9</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>36893774</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D8%26rft.spage%253D523%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252823%252900010-9%26rft_id%253Dinfo%253Apmid%252F36893774%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(23)00010-9&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=36893774&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-143-1" title="View reference 143 in text" id="ref-143">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.143" data-doi="10.1016/j.jhep.2018.11.005"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mathurin</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thursz</span> <span class="cit-name-given-names">M</span></span></li></ol><cite>. <span class="cit-article-title">Endpoints and patient stratification in clinical trials for alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">70</span>:<span class="cit-fpage">314</span>-<span class="cit-lpage">8</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2018.11.005</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>30658732</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D70%26rft.spage%253D314%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2018.11.005%26rft_id%253Dinfo%253Apmid%252F30658732%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2018.11.005&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=30658732&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-144-1" title="View reference 144 in text" id="ref-144">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.144" data-doi="10.1053/j.gastro.2018.05.011"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Louvet</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thursz</span> <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kim</span> <span class="cit-name-given-names">DJ</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Corticosteroids reduce risk of death within 28 days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo-a meta-analysis of individual data from controlled trials</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">155</span>:<span class="cit-fpage">458</span>-<span class="cit-lpage">468.e8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2018.05.011</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29738698</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D155%26rft.spage%253D458%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2018.05.011%26rft_id%253Dinfo%253Apmid%252F29738698%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2018.05.011&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=29738698&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-145-1" title="View reference 145 in text" id="ref-145">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.145" data-doi="10.1053/j.gastro.2016.12.019"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Vergis</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Atkinson</span> <span class="cit-name-given-names">SR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Knapp</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">In patients with severe alcoholic hepatitis, prednisolone increases susceptibility to infection and infection-related mortality, and is associated with high circulating levels of bacterial DNA</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">152</span>:<span class="cit-fpage">1068</span>-<span class="cit-lpage">1077.e4</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2016.12.019</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>28043903</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D152%26rft.spage%253D1068%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2016.12.019%26rft_id%253Dinfo%253Apmid%252F28043903%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2016.12.019&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=28043903&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-146-1" title="View reference 146 in text" id="ref-146">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.146" data-doi="10.1111/apt.15335"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Forrest</span> <span class="cit-name-given-names">EH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Storey</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sinha</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">STOPAH NLR Group</span></li></ol><cite>. <span class="cit-article-title">Baseline neutrophil-to-lymphocyte ratio predicts response to corticosteroids and is associated with infection and renal dysfunction in alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">Aliment Pharmacol Ther</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">50</span>:<span class="cit-fpage">442</span>-<span class="cit-lpage">53</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/apt.15335</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31313853</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAliment%2BPharmacol%2BTher%26rft.volume%253D50%26rft.spage%253D442%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fapt.15335%26rft_id%253Dinfo%253Apmid%252F31313853%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/apt.15335&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31313853&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-147-1" title="View reference 147 in text" id="ref-147">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.147" data-doi="10.14309/ajg.0000000000000912"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Atkinson</span> <span class="cit-name-given-names">SR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Grove</span> <span class="cit-name-given-names">JI</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Liebig</span> <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">In severe alcoholic hepatitis, serum keratin-18 fragments are diagnostic, prognostic, and theragnostic biomarkers</span>. <abbr class="cit-jnl-abbrev">Am J Gastroenterol</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">115</span>:<span class="cit-fpage">1857</span>-<span class="cit-lpage">68</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.14309/ajg.0000000000000912</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33156105</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAm%2BJ%2BGastroenterol%26rft.volume%253D115%26rft.spage%253D1857%26rft_id%253Dinfo%253Adoi%252F10.14309%252Fajg.0000000000000912%26rft_id%253Dinfo%253Apmid%252F33156105%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.14309/ajg.0000000000000912&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33156105&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-148-1" title="View reference 148 in text" id="ref-148">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.148" data-doi="10.1111/j.1600-6143.2009.02869.x"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Burra</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Senzolo</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Adam</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">ELITA</span>, </li><li><span class="cit-auth cit-collab">ELTR Liver Transplant Centers</span></li></ol><cite>. <span class="cit-article-title">Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry)</span>. <abbr class="cit-jnl-abbrev">Am J Transplant</abbr><span class="cit-pub-date">2010</span>;<span class="cit-vol">10</span>:<span class="cit-fpage">138</span>-<span class="cit-lpage">48</span>.<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1111/j.1600-6143.2009.02869.x</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>19951276</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DAmerican%2Bjournal%2Bof%2Btransplantation%2B%253A%2B%2Bofficial%2Bjournal%2Bof%2Bthe%2BAmerican%2BSociety%2Bof%2BTransplantation%2Band%2Bthe%2BAmerican%2BSociety%2Bof%2BTransplant%2BSurgeons%26rft.stitle%253DAm%2BJ%2BTransplant%26rft.aulast%253DBurra%26rft.auinit1%253DP.%26rft.volume%253D10%26rft.issue%253D1%26rft.spage%253D138%26rft.epage%253D148%26rft.atitle%253DLiver%2Btransplantation%2Bfor%2Balcoholic%2Bliver%2Bdisease%2Bin%2BEurope%253A%2Ba%2Bstudy%2Bfrom%2Bthe%2BELTR%2B%2528European%2BLiver%2BTransplant%2BRegistry%2529.%26rft_id%253Dinfo%253Adoi%252F10.1111%252Fj.1600-6143.2009.02869.x%26rft_id%253Dinfo%253Apmid%252F19951276%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1111/j.1600-6143.2009.02869.x&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19951276&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-149-1" title="View reference 149 in text" id="ref-149">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.149" data-doi="10.1016/j.jhep.2021.02.033"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Pose</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Torrents</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Reverter</span> <span class="cit-name-given-names">E</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">A notable proportion of liver transplant candidates with alcohol-related cirrhosis can be delisted because of clinical improvement</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">75</span>:<span class="cit-fpage">275</span>-<span class="cit-lpage">83</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2021.02.033</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33746085</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D75%26rft.spage%253D275%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2021.02.033%26rft_id%253Dinfo%253Apmid%252F33746085%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2021.02.033&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33746085&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-150-1" title="View reference 150 in text" id="ref-150">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.150" data-doi="10.1053/j.gastro.2021.08.050"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kim</span> <span class="cit-name-given-names">WR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Mannalithara</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Heimbach</span> <span class="cit-name-given-names">JK</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">MELD 3.0: The model for end-stage liver disease updated for the modern era</span>. <abbr class="cit-jnl-abbrev">Gastroenterology</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">161</span>:<span class="cit-fpage">1887</span>-<span class="cit-lpage">1895.e4</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1053/j.gastro.2021.08.050</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34481845</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGastroenterology%26rft.volume%253D161%26rft.spage%253D1887%26rft_id%253Dinfo%253Adoi%252F10.1053%252Fj.gastro.2021.08.050%26rft_id%253Dinfo%253Apmid%252F34481845%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1053/j.gastro.2021.08.050&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34481845&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-151-1" title="View reference 151 in text" id="ref-151">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.151" data-doi="10.1136/gut.2007.131730"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Neuberger</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Gimson</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Davies</span> <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">Liver Advisory Group</span>, </li><li><span class="cit-auth cit-collab">UK Blood and Transplant</span></li></ol><cite>. <span class="cit-article-title">Selection of patients for liver transplantation and allocation of donated livers in the UK</span>. <abbr class="cit-jnl-abbrev">Gut</abbr><span class="cit-pub-date">2008</span>;<span class="cit-vol">57</span>:<span class="cit-fpage">252</span>-<span class="cit-lpage">7</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1136/gut.2007.131730</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>17895356</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DGut%26rft_id%253Dinfo%253Adoi%252F10.1136%252Fgut.2007.131730%26rft_id%253Dinfo%253Apmid%252F17895356%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NjoiZ3V0am5sIjtzOjU6InJlc2lkIjtzOjg6IjU3LzIvMjUyIjtzOjQ6ImF0b20iO3M6Mjk6Ii9ibWovMzgzL2Jtai0yMDIzLTA3NzA5MC5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span><span class="cit-sep cit-reflinks-variant-name-sep">/</span><span class="cit-reflinks-full-text"><span class="free-full-text">FREE </span>Full Text</span></span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-152-1" title="View reference 152 in text" id="ref-152">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.152" data-doi="10.1186/s12876-019-1050-9"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Chuncharunee</span> <span class="cit-name-given-names">L</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yamashiki</span> <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Thakkinstian</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sobhonslidsuk</span> <span class="cit-name-given-names">A</span></span></li></ol><cite>. <span class="cit-article-title">Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease: a systematic review and meta-analysis</span>. <abbr class="cit-jnl-abbrev">BMC Gastroenterol</abbr><span class="cit-pub-date">2019</span>;<span class="cit-vol">19</span>:<span class="cit-fpage">150</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1186/s12876-019-1050-9</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31438857</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DBMC%2BGastroenterol%26rft.volume%253D19%26rft.spage%253D150%26rft_id%253Dinfo%253Adoi%252F10.1186%252Fs12876-019-1050-9%26rft_id%253Dinfo%253Apmid%252F31438857%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1186/s12876-019-1050-9&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31438857&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-153-1" title="View reference 153 in text" id="ref-153">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.153" data-doi="10.1056/NEJMoa1105703"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Mathurin</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Moreno</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Samuel</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Early liver transplantation for severe alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">N Engl J Med</abbr><span class="cit-pub-date">2011</span>;<span class="cit-vol">365</span>:<span class="cit-fpage">1790</span>-<span class="cit-lpage">800</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1056/NEJMoa1105703</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>22070476</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DMathurin%26rft.auinit1%253DP.%26rft.volume%253D365%26rft.issue%253D19%26rft.spage%253D1790%26rft.epage%253D1800%26rft.atitle%253DEarly%2Bliver%2Btransplantation%2Bfor%2Bsevere%2Balcoholic%2Bhepatitis.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1105703%26rft_id%253Dinfo%253Apmid%252F22070476%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1056/NEJMoa1105703&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=22070476&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a><a href="/lookup/external-ref?access_num=000296762800008&link_type=ISI" class="cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience"><span>Web of Science</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-154-1" title="View reference 154 in text" id="ref-154">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.154" data-doi="10.1016/S2468-1253(21)00430-1"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Louvet</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Labreuche</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Moreno</span> <span class="cit-name-given-names">C</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">QuickTrans trial study group</span></li></ol><cite>. <span class="cit-article-title">Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study</span>. <abbr class="cit-jnl-abbrev">Lancet Gastroenterol Hepatol</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">7</span>:<span class="cit-fpage">416</span>-<span class="cit-lpage">25</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/S2468-1253(21)00430-1</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>35202597</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DLancet%2BGastroenterol%2BHepatol%26rft.volume%253D7%26rft.spage%253D416%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS2468-1253%252821%252900430-1%26rft_id%253Dinfo%253Apmid%252F35202597%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/S2468-1253(21)00430-1&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=35202597&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-155-1" title="View reference 155 in text" id="ref-155">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.155" data-doi="10.1016/j.jhep.2017.11.017"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Forrest</span> <span class="cit-name-given-names">EH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Atkinson</span> <span class="cit-name-given-names">SR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Richardson</span> <span class="cit-name-given-names">P</span></span>, </li><li><span class="cit-etal">et al.</span>, </li><li><span class="cit-auth cit-collab">STOPAH trial Management Group</span></li></ol><cite>. <span class="cit-article-title">Application of prognostic scores in the STOPAH trial: Discriminant function is no longer the optimal scoring system in alcoholic hepatitis</span>. <abbr class="cit-jnl-abbrev">J Hepatol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">68</span>:<span class="cit-fpage">511</span>-<span class="cit-lpage">8</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jhep.2017.11.017</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29175535</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BHepatol%26rft.volume%253D68%26rft.spage%253D511%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jhep.2017.11.017%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jhep.2017.11.017&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-156-1" title="View reference 156 in text" id="ref-156">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.156" data-doi="10.1002/hep.32110"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Musto</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Stanfield</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ley</span> <span class="cit-name-given-names">D</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lucey</span> <span class="cit-name-given-names">MR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Eickhoff</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Rice</span> <span class="cit-name-given-names">JP</span></span></li></ol><cite>. <span class="cit-article-title">Recovery and outcomes of patients denied early liver transplantation for severe alcohol-associated hepatitis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2022</span>;<span class="cit-vol">75</span>:<span class="cit-fpage">104</span>-<span class="cit-lpage">14</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.32110</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34387875</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D75%26rft.spage%253D104%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.32110%26rft_id%253Dinfo%253Apmid%252F34387875%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.32110&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34387875&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-157-1" title="View reference 157 in text" id="ref-157">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.157" data-doi="10.1001/jamanetworkopen.2021.31132"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Anderson</span> <span class="cit-name-given-names">MS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Valbuena</span> <span class="cit-name-given-names">VSM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span> <span class="cit-name-given-names">CS</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Association of COVID-19 with new waiting list registrations and liver transplantation for alcoholic hepatitis in the United States</span>. <abbr class="cit-jnl-abbrev">JAMA Netw Open</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">4</span>:<span class="cit-elocation-id">e2131132</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1001/jamanetworkopen.2021.31132</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>34698851</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJAMA%2BNetw%2BOpen%26rft.volume%253D4%26rft.spage%253D2131132e%26rft_id%253Dinfo%253Adoi%252F10.1001%252Fjamanetworkopen.2021.31132%26rft_id%253Dinfo%253Apmid%252F34698851%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1001/jamanetworkopen.2021.31132&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=34698851&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-158-1" title="View reference 158 in text" id="ref-158">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.158" data-doi="10.1016/j.cgh.2016.10.029"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Philips</span> <span class="cit-name-given-names">CA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Pande</span> <span class="cit-name-given-names">A</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shasthry</span> <span class="cit-name-given-names">SM</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study</span>. <abbr class="cit-jnl-abbrev">Clin Gastroenterol Hepatol</abbr><span class="cit-pub-date">2017</span>;<span class="cit-vol">15</span>:<span class="cit-fpage">600</span>-<span class="cit-lpage">2</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.cgh.2016.10.029</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>27816755</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DClin%2BGastroenterol%2BHepatol%26rft.volume%253D15%26rft.spage%253D600%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.cgh.2016.10.029%26rft_id%253Dinfo%253Apmid%252Fhttp%253A%252F%252Fwww.n%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.cgh.2016.10.029&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=http://www.n&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-159-1" title="View reference 159 in text" id="ref-159">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.159" data-doi="10.1016/j.jlr.2021.100063"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Wang</span> <span class="cit-name-given-names">Y</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lin</span> <span class="cit-name-given-names">W</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brown</span> <span class="cit-name-given-names">JE</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes</span>. <abbr class="cit-jnl-abbrev">J Lipid Res</abbr><span class="cit-pub-date">2021</span>;<span class="cit-vol">62</span>:<span class="cit-elocation-id">100063</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1016/j.jlr.2021.100063</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>33705741</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DJ%2BLipid%2BRes%26rft.volume%253D62%26rft.spage%253D100063%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jlr.2021.100063%26rft_id%253Dinfo%253Apmid%252F33705741%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1016/j.jlr.2021.100063&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=33705741&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-160-1" title="View reference 160 in text" id="ref-160">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.160" data-doi="10.1002/hep.31046"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Arab</span> <span class="cit-name-given-names">JP</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sehrawat</span> <span class="cit-name-given-names">TS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Simonetto</span> <span class="cit-name-given-names">DA</span></span>, </li><li><span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis</span>. <abbr class="cit-jnl-abbrev">Hepatology</abbr><span class="cit-pub-date">2020</span>;<span class="cit-vol">72</span>:<span class="cit-fpage">441</span>-<span class="cit-lpage">53</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1002/hep.31046</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31774566</span></cite></div><div class="cit-extra"><a href="{openurl}?query=rft.jtitle%253DHepatology%26rft.volume%253D72%26rft.spage%253D441%26rft_id%253Dinfo%253Adoi%252F10.1002%252Fhep.31046%26rft_id%253Dinfo%253Apmid%252F31774566%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx" class="cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url"><span>OpenUrl</span></a><a href="/lookup/external-ref?access_num=10.1002/hep.31046&link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31774566&link_type=MED&atom=%2Fbmj%2F383%2Fbmj-2023-077090.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-161-1" title="View reference 161 in text" id="ref-161">↵</a><div class="cit ref-cit ref-journal" id="cit-383.nov20_5.e077090.161" data-doi="10.1038/ajg.2017.469"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Singal</span> <span class="cit-name-given-names">AK</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Bataller</span> <span class="cit-name-given-names">R</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ahn</span> <span class="cit-name-given-names">J</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kamath</span> <span class="cit-name-given-names">PS</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Shah</span> <span class="cit-name-given-names">VH</span></span></li></ol><cite>. <span class="cit-article-title">ACG clinical guideline: alcoholic liver disease</span>. <abbr class="cit-jnl-abbrev">Am J Gastroenterol</abbr><span class="cit-pub-date">2018</span>;<span class="cit-vol">113</span>:<span class="cit-fpage">175</span>-<span class="cit-lpage">94</span>. .<span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1038/ajg.2017.469</span> <span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>29336434</span></cite></div><div class="cit-extra"><a 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