Talking to your doctor | AMVUTTRA® (vutrisiran)

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# "> <head> <link rel="preconnect" "href=https://cdn.fonts.net"> <link href="https://cdn.fonts.net/kit/536f8cf7-1547-4379-8e77-69345f0120c3/536f8cf7-1547-4379-8e77-69345f0120c3.css" rel="stylesheet" /> <meta charset="utf-8" /> <meta name="description" content="AMVUTTRA® is a prescription medicine given once every 3 months by a healthcare professional to treat the polyneuropathy caused by hATTR amyloidosis in adults. See Important Safety Information on low vitamin A levels." /> <meta name="robots" content="index, follow" /> <link rel="canonical" href="https://www.amvuttra.com/talking-to-your-doctor" /> <meta property="og:site_name" content="AMVUTTRA® (vutrisiran)" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://www.amvuttra.com/talking-to-your-doctor" /> <meta property="og:title" content="Talking to your doctor | AMVUTTRA® (vutrisiran)" /> <meta property="og:description" content="AMVUTTRA® is a prescription medicine given once every 3 months by a healthcare professional to treat the polyneuropathy caused by hATTR amyloidosis in adults. See Important Safety Information on low vitamin A levels." /> <meta property="og:image" content="https://www.amvuttra.com/sites/default/files/AMVUTTRA_Patient_facebook_og.png" /> <meta property="og:locale" content="en_US" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:title" content="Talking to your doctor | AMVUTTRA® (vutrisiran)" /> <meta name="twitter:description" content="AMVUTTRA® is a prescription medicine given once every 3 months by a healthcare professional to treat the polyneuropathy caused by hATTR amyloidosis in adults. See Important Safety Information on low vitamin A levels." /> <meta name="twitter:site" content="https://www.amvuttra.com/talking-to-your-doctor" /> <meta name="twitter:image" content="https://www.amvuttra.com/sites/default/files/AMVUTTRA_Patient_twitter_og.png" /> <meta name="Generator" content="Drupal 9 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/amvuttra/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Talking to your doctor | AMVUTTRA® (vutrisiran)</title> <link rel="apple-touch-icon-precomposed" sizes="57x57" href="/sites/default/files/apple-touch-icon-57x57.png" /> <link rel="apple-touch-icon-precomposed" sizes="114x114" href="/sites/default/files/apple-touch-icon-114x114.png" /> <link rel="apple-touch-icon-precomposed" sizes="72x72" href="/sites/default/files/apple-touch-icon-72x72.png" /> <link rel="apple-touch-icon-precomposed" sizes="144x144" href="/sites/default/files/apple-touch-icon-144x144.png" /> <link rel="apple-touch-icon-precomposed" sizes="120x120" href="/sites/default/files/apple-touch-icon-120x120.png" /> <link rel="apple-touch-icon-precomposed" sizes="152x152" href="/sites/default/files/apple-touch-icon-152x152.png" /> <link rel="icon" type="image/png" href="/sites/default/files/favicon-32x32.png" sizes="32x32" /> <link rel="icon" type="image/png" href="/sites/default/files/favicon-16x16.png" sizes="16x16" /> <meta name="application-name" content="AMVUTTRA is now approved | AMVUTTRA™ (vutrisiran)"/> <meta name="msapplication-TileColor" content="#FFFFFF" /> <meta name="msapplication-TileImage" content="/sites/default/files/mstile-144x144.png" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_JQyZ9StD4-4I5jikYtL8icbvn1b-f6xMTWUzpXDhKlc.css" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/slick-carousel@1.8.1/slick/slick.css" defer /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_aGpHy4Vo74yJcpOFus362tYZwwtQhEY3N6EfUTmkPWI.css" defer /> <meta name="google-site-verification" content="aWdzAC5piEa49SIiq0eal5COU8RO_NqdCeRdri7zCmQ" />  <script> (function(h,o,t,j,a,r){ h.hj=h.hj||function(){(h.hj.q=h.hj.q||[]).push(arguments)}; h._hjSettings={hjid:3724776,hjsv:6}; a=o.getElementsByTagName('head')[0]; r=o.createElement('script');r.async=1; r.src=t+h._hjSettings.hjid+j+h._hjSettings.hjsv; a.appendChild(r); })(window,document,'https://static.hotjar.com/c/hotjar-','.js?sv='); </script>  <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5TV86HH');</script>  </head> <body class="talking-to-your-doctor">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-WXXDWPXP" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <a href="#main-content" class="skip-to-content visually-hidden focusable"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <header class="header fixed w-full z-[600]" role="banner"> <div class="h-1 w-full bg-cranberry header-bar-desktop"></div> <div class="header-top"> <div class="container"> <div class="inner-container"> <div class="region region--navbar-top"> <nav class="topmenudesktop-menu" role="navigation" aria-labelledby="block-topmenudesktop-menu" id="block-topmenudesktop"> <div class="visually-hidden" id="block-topmenudesktop-menu">Top Menu Desktop</div> <ul class="navbar"> <li class="nav-item" > <a href="" class="nav-link "> For US audiences only </a> </li> <li class="nav-item" > <a href="https://www.alnylam.com/amvuttra-us-prescribing-information" class="nav-link "> Prescribing Information </a> </li> <li class="nav-item" > <a href="/patient-educator" class="nav-link "> Connect With an Alnylam Educator </a> </li> <li class="nav-item" > <a href="https://instagram.com/amvuttra_vutrisiran" class="nav-link "> Instagram </a> </li> <li class="nav-item" > <a href="https://www.facebook.com/AMVUTTRA" class="nav-link "> Facebook </a> </li> </ul> </nav> <nav class="topmenumobile-menu" role="navigation" aria-labelledby="block-topmenumobile-menu" id="block-topmenumobile"> <div class="visually-hidden" id="block-topmenumobile-menu">Top Menu Mobile</div> <ul class="navbar"> <li class="nav-item" > <a href="https://www.alnylam.com/amvuttra-us-prescribing-information" class="nav-link "> Prescribing Information </a> </li> <li class="nav-item" > <a href="#isi" class="nav-link "> Important Safety Information </a> </li> </ul> </nav> </div> </div> </div> </div> <div class="h-1 w-full bg-cranberry header-bar-mobile"></div> <div class="header-content"> <div class="container grid grid-flow-col justify-between items-center"> <div class="header-logo"> <a href="/"><img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA® (vutrisiran) logo" srcset="" width="195" height="auto"></a> </div> <div class="region region--navbar"> <nav class="amvuttra-main-menu-menu" role="navigation" aria-labelledby="block-amvuttra-main-menu-menu" id="block-amvuttra-main-menu"> <div class="visually-hidden" id="block-amvuttra-main-menu-menu">Main navigation</div> <ul class="navbar"> <li class="nav-item" > <a href="/disease-overview" class="nav-link "> Disease Overview </a> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="/about-amvuttra" class="nav-link nav-link-submenu"> About AMVUTTRA <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/about-amvuttra/how-amvuttra-works" class="nav-link "> How AMVUTTRA Works </a> </li> <li class="nav-item" > <a href="/about-amvuttra/how-amvuttra-was-studied" class="nav-link "> How AMVUTTRA Was Studied </a> </li> </ul> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="/how-amvuttra-may-help" class="nav-link nav-link-submenu"> How AMVUTTRA May Help <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/how-amvuttra-may-help/results-with-amvuttra" class="nav-link "> Results With AMVUTTRA </a> </li> <li class="nav-item" > <a href="/how-amvuttra-may-help/possible-side-effects" class="nav-link "> Possible Side Effects </a> </li> </ul> </li> <li class="nav-item" > <a href="/dosing" class="nav-link "> Dosing </a> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="/resources-support" class="nav-link nav-link-submenu"> Resources & Support <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/resources-support/resources" class="nav-link "> Resources </a> </li> <li class="nav-item" > <a href="/resources-support/video-resources" class="nav-link "> Video Resources </a> </li> <li class="nav-item" > <a href="/resources-support/alnylam-assist" class="nav-link "> Alnylam Assist<sup>®</sup> </a> </li> <li class="nav-item" > <a href="/patient-educator" class="nav-link "> Connect With an Alnylam Educator </a> </li> <li class="nav-item" > <a href="/resources-support/programs-and-events" class="nav-link "> Programs and Events </a> </li> <li class="nav-item" > <a href="/resources-support/find-a-treatment-center" class="nav-link "> Find a Treatment Center </a> </li> </ul> </li> </ul> </nav> <nav class="mainmenumobile-menu" role="navigation" aria-labelledby="block-mainmenumobile-menu" id="block-mainmenumobile"> <div class="visually-hidden" id="block-mainmenumobile-menu">Main Menu Mobile</div> <ul class="navbar"> <li class="nav-item" > <a href="/disease-overview" class="nav-link "> Disease Overview </a> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="/about-amvuttra" class="nav-link nav-link-submenu"> About AMVUTTRA <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/about-amvuttra/how-amvuttra-works" class="nav-link "> How AMVUTTRA Works </a> </li> <li class="nav-item" > <a href="/about-amvuttra/how-amvuttra-was-studied" class="nav-link "> How AMVUTTRA Was Studied </a> </li> </ul> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="" class="nav-link nav-link-submenu"> How AMVUTTRA May Help <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/how-amvuttra-may-help/results-with-amvuttra" class="nav-link "> Results With AMVUTTRA </a> </li> <li class="nav-item" > <a href="/how-amvuttra-may-help/possible-side-effects" class="nav-link "> Possible Side Effects </a> </li> </ul> </li> <li class="nav-item" > <a href="/dosing" class="nav-link "> Dosing </a> </li> <li class="nav-item" data-nav-item-submenu="true"> <a href="/resources-support" class="nav-link nav-link-submenu"> Resources & Support <button class="toggle-submenu desktop"></button> </a> <button class="toggle-submenu mobile"></button> <ul class="navbar submenu"> <li class="nav-item" > <a href="/resources-support/resources" class="nav-link "> Resources </a> </li> <li class="nav-item" > <a href="/resources-support/video-resources" class="nav-link "> Video Resources </a> </li> <li class="nav-item" > <a href="/resources-support/alnylam-assist" class="nav-link "> Alnylam Assist® </a> </li> <li class="nav-item" > <a href="/patient-educator" class="nav-link "> Connect With an Alnylam Educator </a> </li> <li class="nav-item" > <a href="/resources-support/programs-and-events" class="nav-link "> Programs and Events </a> </li> <li class="nav-item" > <a href="/resources-support/find-a-treatment-center" class="nav-link "> Find a Treatment Center </a> </li> </ul> </li> <li class="nav-item" > <a href="/patient-educator" class="nav-link "> Connect With an Alnylam Educator </a> </li> <li class="nav-item" > <a href="/stay-informed" class="nav-link "> Stay Informed </a> </li> <li class="nav-item" > <a href="https://www.facebook.com/AMVUTTRA" class="nav-link "> Facebook </a> </li> <li class="nav-item" > <a href="https://instagram.com/amvuttra_vutrisiran" class="nav-link "> Instagram </a> </li> <li class="nav-item" > <a href="https://www.amvuttrahcp.com" class="nav-link "> For healthcare providers </a> </li> </ul> </nav> </div> <div class="flex items-center lg1:hidden"> <a href="/patient-educator" class="connect-with-educator-mobile"> <img class="red" src="/themes/amvuttra/assets/images/0.0-icon-connect-with-educator-red.svg" width="18" height="22" alt="Connect with an Alnylam Educator icon"> <span>Connect</span> </a> <div class="toggle-menu flex justify-end ml-auto"> <img class="touch-none open show" src="/themes/amvuttra/assets/images/0.0-icn-hamburger.svg" width="30" height="23" alt="Open menu"> <img class="touch-none close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" width="30" height="30" alt="Close menu"> </div> </div> </div> </div> </header> <main class="main" role="main"> <a id="main-content" tabindex="-1"></a> <div class="main__content_top"> </div> <div class="main__content relative"> <div class="region region--content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-amvuttra-page-title" class="block-page-title"> <div class="container"> </div> </div> <div id="block-amvuttra-content" class="block-system-main"> <article data-history-node-id="21" role="article" about="/talking-to-your-doctor" class="node node--basic-page-with-sections --view-mode--full"> <div class="node__content"> <div class="sections basic_page_with_sections__item"> <div class="sections__item --custom_html_code"> <div class="html-code"> <div class="html-code__item"><h1 style="height:1px;overflow:hidden;">Talking to your doctor</h1> <style type="text/css"> <![CDATA[/* ><!]]>*/ </style><p><iframe allowfullscreen="" class="jebbit-iframe" frameborder="0" id="jebbit-iframe" mozallowfullscreen="" onload="function embedJebbit(a) { var b = document.querySelector(a); function c() { var c, a, d, e; a = (c = b).getBoundingClientRect(), d = c.clientHeight / 2, e = c.clientWidth / 2, a.top >= 0 && a.left >= 0 && a.top <= (window.innerHeight || document.documentElement.clientHeight) - d && a.left <= (window.innerWidth || document.documentElement.clientWidth) - e && b.contentWindow.postMessage("startJebbitCampaign", "*") } window.addEventListener("message", function(a) { a && ("jebbitSessionCreated" === a.data ? ((f = window.removeEventListener)("DOMContentLoaded", c, !1), f("load", c, !1), f("scroll", c, !1), f("resize", c, !1)) : "jebbitCampaignLoaded" === a.data ? c() : a.data && "redirect" === a.data.action && a.data.options && a.data.options.link && (window.location.href = a.data.options.link)); var e, f, d = a.data; if (a.data.height) { document.querySelector("#jebbit-iframe").style.height = a.data.height + "px"; } }, !1)}embedJebbit(".jebbit-iframe")" seamless="true" src="https://alnylam.jebbit.com/4w9gzjmp?L=Full+Page&deferred=true" style="min-width: 100%; min-height: 600px;" webkitallowfullscreen=""></iframe></p> </div> </div> </div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h2>Important Safety Information and Indication</h2> <h3>Important Safety Information</h3> <h4>What are the most important things I should know about AMVUTTRA<sup>®</sup> (vutrisiran)?</h4> <p>AMVUTTRA can cause:</p> <ul><li> <h4>Low Vitamin A Levels</h4> <p>Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</p> <p>Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</p> </li> </ul><h4>What are the common side effects of AMVUTTRA?</h4> <p>The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</p> <p>These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</p> <h3>Indication</h3> <h4>What is AMVUTTRA?</h4> <p>AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</p> <h4>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h4> <div class="w-full text-center"><a class="for-hcp" href="https://www.amvuttrahcp.com">For healthcare providers</a></div></div> </div> </div> </div><div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --embed_block"> <div class="block"> <div class="block__item"><div id="block-isicontent" class="block-block-content:0a26fb4c-c9db-4f7e-9c83-83eee0fd1104"> <div class="body"> <div class="body__item"><div class="h1">Important Safety Information and Indication</div> <div class="h2">Important Safety Information</div> <div class="h3">What are the most important things I should know about AMVUTTRA® (vutrisiran)?</div> <div class="p">AMVUTTRA can cause:</div> <div class="ul"> <div class="li"> <div class="h3">Low Vitamin A Levels</div> <div class="p">Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</div> <div class="p">Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</div> </div> </div> <div class="h3">What are the common side effects of AMVUTTRA?</div> <div class="p">The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</div> <div class="p">These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</div> <div class="h2">Indication</div> <div class="h3">What is AMVUTTRA?</div> <div class="p">AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</div> <div class="h3">For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf">Prescribing Information</a>.</div> <div class="p"><a href="https://www.amvuttrahcp.com">For healthcare providers</a></div> </div> </div> </div> </div> </div> </div> <div class="paragraphs__item --container_block"> <div class="blocks"> <div class="blocks__item --link"> <div class="link"> <div class="link__item"><a href="/stay-informed">Stay Informed</a></div> </div> </div> <div class="blocks__item --link_icon"><a class="link" href="https://www.amvuttrahcp.com" title="For healthcare providers" > For healthcare providers <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Go to page icon</span> <svg xmlns="http://www.w3.org/2000/svg" width="15.811" height="15.811" viewBox="0 0 15.811 15.811"><g transform="translate(0.75 1.061)"><path d="M6.125,0H1.75A1.75,1.75,0,0,0,0,1.75V9.625a1.75,1.75,0,0,0,1.75,1.75H9.625a1.75,1.75,0,0,0,1.75-1.75V5.25" transform="translate(0 2.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,8.75,8.75,0" transform="translate(5.25 0)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,0H4.375V4.375" transform="translate(9.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div>  <div class="fixed hidden inset-0 overflow-y-auto h-full w-full items-start md:items-center" id="modals-overflow">  <div class="modal" id="welcome-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">The site you are about to enter is intended for US healthcare professionals.</h2> <p class="description">Are you a US healthcare professional?</p> <a href="#" tabindex="1" class="confirm-btn" data-modal-target="1"> Confirm and enter <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn icon-link-external-right" href="#" data-modal-target="1">Visit patient site</a> </div> </div> </div> <div class="modal" id="corporative-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description">You are now being directed to another Alnylam website.</p> <a class="confirm-btn" href="#" target="_blank" data-modal-target="2"> Proceed <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn" href="#" data-modal-target="2">Cancel</a> </div> </div> </div> <div class="modal" id="thirdparty-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description"> Links to all outside sites are provided as a reference for our visitors. Alnylam Pharmaceuticals does not endorse and is not responsible for the content on sites that are not owned and operated by Alnylam Pharmaceuticals. </p> <a class="confirm-btn" href="#" target="_blank" data-modal-target="3"> Proceed <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a class="close-btn" href="#" data-modal-target="3">Cancel</a> </div> </div> </div> <div class="modal" id="duplicate-email"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">This email address is already in use.</h2> <p class="description">Please press Cancel to enter another email, or press Update to receive an email that will allow you to update your preferences.</p> <button class="update-email-btn" data-modal-target="4"> Update <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </button> <button class="close-btn" data-modal-target="4">Cancel</button> </div> </div> </div> <div class="modal" id="email-sent"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">Email sent!</h2> <p class="description">A link has been sent to your email address.</p> <button class="confirm-email-btn" data-modal-target="5">Ok</button> </div> </div> </div> </div> <div class="waves footer"> <div class="layer"> <img class="left" src="/themes/amvuttra/assets/images/footer-waves-left.svg" alt="Footer Waves Left"> <img class="right" src="/themes/amvuttra/assets/images/footer-waves-right.svg" alt="Footer Waves Right"> </div> </div> <footer class="footer bg-cranberry pt-10 pb-14" role="contentinfo"> <div class="container"> <div class="region region--footer"> <nav class="amvuttra-footer-menu" role="navigation" aria-labelledby="block-amvuttra-footer-menu" id="block-amvuttra-footer"> <div class="visually-hidden" id="block-amvuttra-footer-menu">Footer menu</div> <ul class="navbar"> <li class="nav-item" > <a href="https://alnylampolicies.com/privacy" class="nav-link "> Privacy Policy </a> </li> <li class="nav-item" > <a href="https://alnylampolicies.com/legal" class="nav-link "> Legal Notice </a> </li> <li class="nav-item" > <a href="https://www.alnylam.com/contact-us" class="nav-link "> Contact Us </a> </li> <li class="nav-item" > <a href="/sitemap" class="nav-link "> Site Map </a> </li> </ul> </nav> </div> <a href="https://www.alnylam.com" class="ext-link-corporative" alt="Alnylam® Pharmaceuticals"> <img src="/themes/amvuttra/assets/images/0.0-alnlyam-pharmaceuticals-logo-ko.svg" alt="Alnylam Pharmaceuticals logo" /> </a> <p> AMVUTTRA, Alnylam Assist, and their associated logos are trademarks of Alnylam Pharmaceuticals, Inc. </p> <p> © 2024 Alnylam Pharmaceuticals, Inc. All rights reserved. This site is intended for US audiences. AMV-USA-00240 </p> </div> </footer> </main> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","scriptPath":null,"pathPrefix":"","currentPath":"node\/21","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"pelLookup":{"googleMapApiKey":"AIzaSyAPqmol7uZefGjLQ80QQt3gDTbpWImcD00","ipinfoApiKey":"5fa19730bfdcc1","pelLookupApiUrl":"https:\/\/euxz9xgkgd.execute-api.us-east-2.amazonaws.com\/Alnylam-PROD\/Alnylam-get-PEL-PROD","pelLookupApiKey":"kS0uEhG7aBadTSg8HBthN1rgJQMM7OOg9jfnZWBA"},"user":{"uid":0,"permissionsHash":"53dad248b9a72c27286c4be47b6468d2066464592bc4f053edc1a8535721e5ac"}}</script> <script src="/sites/default/files/js/js_AfqYzlW71UNW9PsotE5ELou-r50UGYw8JM2cS_29YYs.js"></script> <script src="https://cdn.jsdelivr.net/npm/slick-carousel@1.8.1/slick/slick.min.js" defer></script> <script src="/themes/amvuttra/vendors/tooltipster/tooltipster.bundle.min.js?slpz2w" defer></script> <script src="/themes/amvuttra/assets/js/bundle.js?v=1.x" defer></script> <script src="https://unpkg.com/axios@1.7.2/dist/axios.min.js" defer></script> <script src="/themes/amvuttra/assets/js/pel-lookup.js?slpz2w" defer></script> </body> </html>

CINXE.COM

Talking to your doctor | AMVUTTRA® (vutrisiran)