Educational Resources | AMVUTTRA® (vutrisiran)

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src="/sites/default/files/2024-04/AMVUTTRA-vutrisiran-Treatment-Brochure%402x_0.png" width="360" height="340" alt="Treatment Brochure" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Treatment Brochure</h3> <p>Learn more about treatment with AMVUTTRA®</p> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --embed_block"> <div class="block"> <div class="block__item"><div id="block-webform" class="block-webform"> <span id="webform-submission-select-treatment-brochure-node-14-form-ajax-content"></span><div id="webform-submission-select-treatment-brochure-node-14-form-ajax" class="webform-ajax-form-wrapper" data-effect="none" data-progress-type="fullscreen"><form class="webform-submission-form webform-submission-add-form webform-submission-select-treatment-brochure-form webform-submission-select-treatment-brochure-add-form 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value="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Treatment-Brochure.pdf" selected="selected">English</option><option value="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Treatment-Brochure-Spanish.pdf">Español</option><option value="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Treatment-Brochure-European-Portuguese.pdf">Português Europeu</option></select> </div> <input autocomplete="off" data-drupal-selector="form-qs1p-z9v1uw1j0hcxrvkqgh8qowqnijlbgmibjdllk" type="hidden" name="form_build_id" value="form-Qs1p__z9v1uW1j0HCxrvkQgH8QoWqNIjlbgmIBJDLLk" /> <input data-drupal-selector="edit-webform-submission-select-treatment-brochure-node-14-add-form" type="hidden" name="form_id" value="webform_submission_select_treatment_brochure_node_14_add_form" /> </form> </div> </div> </div> </div> </div> <div class="blocks__item --link_icon"><a class="link" href="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Treatment-Brochure.pdf" title="Download" > Download <div class="image-default"> <div 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aria-hidden="true">Icon Download</span> <svg xmlns="http://www.w3.org/2000/svg" width="39.474" height="50.124" viewBox="0 0 39.474 50.124"><g transform="translate(-11030.176 928.331)"><g transform="translate(11031.276 -927.231)"><path d="M29.572,44.357H4.929A4.929,4.929,0,0,1,0,39.429V4.929A4.929,4.929,0,0,1,4.929,0h17.25L34.5,12.321V39.429A4.929,4.929,0,0,1,29.572,44.357Z" transform="translate(3.361 3.361)" fill="#c9c5da"/><path d="M0,0V10.65a2.662,2.662,0,0,0,2.662,2.662h10.65" transform="translate(23.962)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/><path d="M31.949,47.924H5.325A5.325,5.325,0,0,1,0,42.6V5.325A5.325,5.325,0,0,1,5.325,0H23.962L37.274,13.312V42.6A5.325,5.325,0,0,1,31.949,47.924Z" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/></g><g transform="translate(11043.045 -907.052)"><path d="M.917,0V15.975" transform="translate(7.072 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--view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-03/AMVUTTRA-vutrisiran-Treatment-Journal%402x_0.png" width="360" height="268" alt="Treatment Journal and Planner" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Treatment Journal & Planner</h3> <p>Keep track of your treatment</p> </div> <div class="blocks__item --link_icon"><a class="link" href="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Treatment-Journal.pdf" title="Download" > Download <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Icon Download</span> <svg xmlns="http://www.w3.org/2000/svg" width="39.474" height="50.124" viewBox="0 0 39.474 50.124"><g transform="translate(-11030.176 928.331)"><g transform="translate(11031.276 -927.231)"><path d="M29.572,44.357H4.929A4.929,4.929,0,0,1,0,39.429V4.929A4.929,4.929,0,0,1,4.929,0h17.25L34.5,12.321V39.429A4.929,4.929,0,0,1,29.572,44.357Z" transform="translate(3.361 3.361)" fill="#c9c5da"/><path d="M0,0V10.65a2.662,2.662,0,0,0,2.662,2.662h10.65" transform="translate(23.962)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/><path d="M31.949,47.924H5.325A5.325,5.325,0,0,1,0,42.6V5.325A5.325,5.325,0,0,1,5.325,0H23.962L37.274,13.312V42.6A5.325,5.325,0,0,1,31.949,47.924Z" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/></g><g transform="translate(11043.045 -907.052)"><path d="M.917,0V15.975" transform="translate(7.072 0)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/></g><g transform="translate(11041.925 -908.172)"><path d="M.917,0V15.975" transform="translate(7.072)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/></g></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --link_image"> <div class="link-image"> <div class="link-image__item"> <div class="media media--image --view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-03/AlnylamAssistProviderBrochurePatient.jpg" width="734" height="471" alt="Alnylam Assist® Brochure" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Alnylam Assist<sup>®</sup> Brochure</h3> <p>Learn more about available patient support</p> </div> <div class="blocks__item --link_icon"><a class="link" href="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Alnylam-Assist-Provider-Brochure-Patient.pdf" title="Download" > Download <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Icon Download</span> <svg xmlns="http://www.w3.org/2000/svg" width="39.474" height="50.124" viewBox="0 0 39.474 50.124"><g transform="translate(-11030.176 928.331)"><g transform="translate(11031.276 -927.231)"><path d="M29.572,44.357H4.929A4.929,4.929,0,0,1,0,39.429V4.929A4.929,4.929,0,0,1,4.929,0h17.25L34.5,12.321V39.429A4.929,4.929,0,0,1,29.572,44.357Z" transform="translate(3.361 3.361)" fill="#c9c5da"/><path d="M0,0V10.65a2.662,2.662,0,0,0,2.662,2.662h10.65" transform="translate(23.962)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/><path d="M31.949,47.924H5.325A5.325,5.325,0,0,1,0,42.6V5.325A5.325,5.325,0,0,1,5.325,0H23.962L37.274,13.312V42.6A5.325,5.325,0,0,1,31.949,47.924Z" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/></g><g transform="translate(11043.045 -907.052)"><path d="M.917,0V15.975" transform="translate(7.072 0)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/></g><g transform="translate(11041.925 -908.172)"><path d="M.917,0V15.975" transform="translate(7.072)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/></g></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --link_image"> <div class="link-image"> <div class="link-image__item"> <div class="media media--image --view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-03/AMVUTTRA-vutrisiran-Doctor-Discussion-Guide%402x.png" width="360" height="430" alt="Doctor Discussion Guide" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Doctor Discussion Guide</h3> <p>Fill out this guide and use it to facilitate conversations with your doctor. Try our <a href="/talking-to-your-doctor" style="text-decoration: underline;color: #e7004c;">interactive guide</a>.</p> </div> <div class="blocks__item --link_icon"><a class="link" href="/sites/default/files/pdfs/AMVUTTRA-vutrisiran-Doctor-Discussion-Guide.pdf" title="Download" > Download <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Icon Download</span> <svg xmlns="http://www.w3.org/2000/svg" width="39.474" height="50.124" viewBox="0 0 39.474 50.124"><g transform="translate(-11030.176 928.331)"><g transform="translate(11031.276 -927.231)"><path d="M29.572,44.357H4.929A4.929,4.929,0,0,1,0,39.429V4.929A4.929,4.929,0,0,1,4.929,0h17.25L34.5,12.321V39.429A4.929,4.929,0,0,1,29.572,44.357Z" transform="translate(3.361 3.361)" fill="#c9c5da"/><path d="M0,0V10.65a2.662,2.662,0,0,0,2.662,2.662h10.65" transform="translate(23.962)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/><path d="M31.949,47.924H5.325A5.325,5.325,0,0,1,0,42.6V5.325A5.325,5.325,0,0,1,5.325,0H23.962L37.274,13.312V42.6A5.325,5.325,0,0,1,31.949,47.924Z" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.2"/></g><g transform="translate(11043.045 -907.052)"><path d="M.917,0V15.975" transform="translate(7.072 0)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.75"/></g><g transform="translate(11041.925 -908.172)"><path d="M.917,0V15.975" transform="translate(7.072)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/><path d="M0,0,7.987,7.987,15.975,0" transform="translate(0 7.987)" fill="none" stroke="#4d4084" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.25"/></g></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --link_image"> <div class="link-image"> <div class="link-image__item"> <div class="media media--image --view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/videos-icon.png" width="448" height="230" alt="Video resources" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Videos</h3> <p>Hear from those who have experience with AMVUTTRA</p> </div> <div class="blocks__item --link_icon"><a class="link" href="/video-resources" title="Watch now" > Watch now <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="39.038" height="39.038" viewBox="0 0 39.038 39.038"> <defs> <clipPath id="clip-path"> <rect id="Rectangle_1706" data-name="Rectangle 1706" width="39.038" height="39.038" fill="none"/> </clipPath> </defs> <g id="Group_7315" data-name="Group 7315" transform="translate(0 -2.781)"> <g id="Group_7314" data-name="Group 7314" transform="translate(0 2.781)" clip-path="url(#clip-path)"> <path id="Path_34966" data-name="Path 34966" d="M38.69,21.359A17.189,17.189,0,0,1,21.77,38.806,17.189,17.189,0,0,1,4.851,21.359,17.189,17.189,0,0,1,21.77,3.913,17.189,17.189,0,0,1,38.69,21.359" transform="translate(-0.806 -0.65)" fill="#c9c5da"/> <path id="Path_34967" data-name="Path 34967" d="M38.37,19.685A18.685,18.685,0,1,1,19.685,1,18.685,18.685,0,0,1,38.37,19.685Z" transform="translate(-0.166 -0.166)" fill="none" stroke="#4d4084" stroke-miterlimit="10" stroke-width="2"/> <path id="Path_34968" data-name="Path 34968" d="M17.184,17.021c.134,1.062,0,10.307,0,10.307s.134,1.74,2.543.535l8.317-4.949s1.469-.82-.085-1.865c-.8-.535-8.988-5.681-8.988-5.681S16.923,14.944,17.184,17.021Z" transform="translate(-2.852 -2.548)" fill="none" stroke="#fff" stroke-miterlimit="10" stroke-width="2"/> <path id="Path_34969" data-name="Path 34969" d="M18.5,18.028c.134,1.062,0,10.307,0,10.307s.134,1.74,2.543.535l8.317-4.949s1.469-.82-.085-1.865c-.8-.535-8.988-5.681-8.988-5.681S18.24,15.951,18.5,18.028Z" transform="translate(-3.071 -2.716)" fill="none" stroke="#4d4084" stroke-miterlimit="10" stroke-width="2"/> </g> </g> </svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> <div class="sections__item --single_video"> <div class="title"> <div class="title__item">Watch the video to learn more about the treatment process with AMVUTTRA</div> </div> <div class="image"> <div class="image__item"> <img src="/sites/default/files/2022-09/Treatment-Process-video-screen.jpg" width="770" height="433" alt="Treatment Process With AMVUTTRA video thumbnail" loading="lazy" typeof="foaf:Image" /> </div> </div> <div class="video"> <div class="video__item"> <div class="media media--video --view-mode--default"> <div class="media-video-file"> <div class="media-video-file__item"><a id="video-treatment"></a> <div class="video-item"> <video width="640" height="480" playsinline="playsinline"> <source src="/sites/default/files/2023-03/video-treatment.mp4" type="video/mp4" /> </video> <button class="inner-play-video"></button> <div class="controls"> <button class="play"></button> <div class="time"> <div class="current">00:00</div> </div> <div class="timeline"> <input type="range" name="" id="" min="0" max="100" value="0" step="0.01"> <div class="inner"></div> <div class="bar"></div> </div> <div class="volume-control"> <button class="volume"></button> <input type="range" name="" id="" min="0" max="100" value="100" step="0.05"> <div class="bar"></div> </div>  <button class="fullscreen"></button> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--full"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" id="Layer_2" viewBox="0 0 54.93 54.93"><defs><style>.cls-emailicon-emailicon-1{fill:#c9c5da;}.cls-emailicon-2,.cls-emailicon-3,.cls-emailicon-4{fill:none;stroke-width:2px;}.cls-emailicon-2,.cls-emailicon-4{stroke:#4d4084;}.cls-emailicon-3{stroke:#fff;}.cls-emailicon-3,.cls-emailicon-4{stroke-linecap:round;stroke-linejoin:round;}</style></defs><g id="Layer_1-2"><g id="Mail_icon"><g id="Group_345"><circle id="Oval" class="cls-emailicon-emailicon-1" cx="29.47" cy="29.47" r="23.2"/><path id="Shape" class="cls-emailicon-2" d="M1,27.47C1,12.85,12.85,1,27.47,1s26.47,11.85,26.47,26.47-11.85,26.47-26.47,26.47h0C12.85,53.93,1,42.08,1,27.47Z"/></g><g id="Group_347"><rect id="Rectangle_86" class="cls-emailicon-3" x="15.91" y="17.54" width="26.47" height="21.17" rx="2" ry="2"/><path id="Path_4851" class="cls-emailicon-3" d="M15.91,21.21l13.23,7.94,13.23-7.94"/></g><g id="Group_348"><rect id="Rectangle_86-2" class="cls-emailicon-4" x="14.59" y="16.21" width="26.47" height="21.17" rx="2" ry="2"/><path id="Path_4851-2" class="cls-emailicon-4" d="M14.59,19.89l13.23,7.94,13.23-7.94"/></g></g></g></svg> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <h3>Want to stay informed?</h3> <p>Sign up for email updates <a href="/stay-informed">here</a></p> </div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --title"> <div class="title"> <div class="title__item">Alnylam Patient Education Liaison (PEL)</div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--full"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Start a conversation with your doctor</span> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="Layer_2" viewBox="0 0 56.2 66.78"><defs><style>.cls-have-question-1{fill:none;}.cls-have-question-2{clip-path:url(#clippath);}.cls-have-question-3{fill:#c9c5da;}.cls-have-question-4{fill:#4d4084;}</style><clipPath id="clippath"><rect class="cls-have-question-1" width="56.2" height="66.78"/></clipPath></defs><g id="Layer_1-2"><g class="cls-have-question-2"><g id="ALN_PEL_two_people"><path id="Path_32100" class="cls-have-question-3" 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They are not acting as healthcare providers and are not part of your healthcare team.</p> </div> <div class="blocks__item --link"> <div class="link"> <div class="link__item"><a href="/patient-educator">Connect With an Alnylam Educator</a></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --big_blue_link"><a class="link" href="/video-resources" title="Learn about video resources"> <span class="up-next">Up next</span> <span class="title text-right">Learn about video resources</span> <span class="arrow"> <svg cache-id="18a3c6d249ce44cbb9ffbddd8d1dc4b3" id="ePvaDMrUYOV1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" viewBox="0 0 34 34" shape-rendering="geometricPrecision" text-rendering="geometricPrecision" width="34" height="34"><rect width="34" height="34" rx="0" ry="0" fill="#4d4084"/><g id="ePvaDMrUYOV3" transform="translate(3 0)"><line x1="18.9" y1="26.89" x2="28.8" y2="16.99" fill="none" stroke="#fff" 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</a></div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h2>Important Safety Information and Indication</h2> <h3>Important Safety Information</h3> <h4>What are the most important things I should know about AMVUTTRA<sup>®</sup> (vutrisiran)?</h4> <p>AMVUTTRA can cause:</p> <ul><li> <h4>Low Vitamin A Levels</h4> <p>Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</p> <p>Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</p> </li> </ul><h4>What are the common side effects of AMVUTTRA?</h4> <p>The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</p> <p>These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</p> <h3>Indication</h3> <h4>What is AMVUTTRA?</h4> <p>AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</p> <h4>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h4> <div class="w-full text-center"><a class="for-hcp" href="https://www.amvuttrahcp.com">For healthcare providers</a></div></div> </div> </div> </div><div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --embed_block"> <div class="block"> <div class="block__item"><div id="block-isicontent" class="block-block-content:0a26fb4c-c9db-4f7e-9c83-83eee0fd1104"> <div class="body"> <div class="body__item"><div class="h1">Important Safety Information and Indication</div> <div class="h2">Important Safety Information</div> <div class="h3">What are the most important things I should know about AMVUTTRA® (vutrisiran)?</div> <div class="p">AMVUTTRA can cause:</div> <div class="ul"> <div class="li"> <div class="h3">Low Vitamin A Levels</div> <div class="p">Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</div> <div class="p">Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</div> </div> </div> <div class="h3">What are the common side effects of AMVUTTRA?</div> <div class="p">The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</div> <div class="p">These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</div> <div class="h2">Indication</div> <div class="h3">What is AMVUTTRA?</div> <div class="p">AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</div> <div class="h3">For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf">Prescribing Information</a>.</div> <div class="p"><a href="https://www.amvuttrahcp.com">For healthcare providers</a></div> </div> </div> </div> </div> </div> </div> <div class="paragraphs__item --container_block"> <div class="blocks"> <div class="blocks__item --link"> <div class="link"> <div class="link__item"><a href="/stay-informed">Stay Informed</a></div> </div> </div> <div class="blocks__item --link_icon"><a class="link" href="https://www.amvuttrahcp.com" title="For healthcare providers" > For healthcare providers <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Go to page icon</span> <svg xmlns="http://www.w3.org/2000/svg" width="15.811" height="15.811" viewBox="0 0 15.811 15.811"><g transform="translate(0.75 1.061)"><path d="M6.125,0H1.75A1.75,1.75,0,0,0,0,1.75V9.625a1.75,1.75,0,0,0,1.75,1.75H9.625a1.75,1.75,0,0,0,1.75-1.75V5.25" transform="translate(0 2.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,8.75,8.75,0" transform="translate(5.25 0)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,0H4.375V4.375" transform="translate(9.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div>  <div class="fixed hidden inset-0 overflow-y-auto h-full w-full items-start md:items-center" id="modals-overflow">  <div class="modal" id="welcome-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">The site you are about to enter is intended for US healthcare professionals.</h2> <p class="description">Are you a US healthcare professional?</p> <a href="#" tabindex="1" class="confirm-btn" data-modal-target="1"> Confirm and enter <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn icon-link-external-right" href="#" data-modal-target="1">Visit patient site</a> </div> </div> </div> <div class="modal" id="corporative-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description">You are now being directed to another Alnylam website.</p> <a class="confirm-btn" href="#" target="_blank" data-modal-target="2"> Proceed <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn" href="#" data-modal-target="2">Cancel</a> </div> </div> </div> <div class="modal" id="thirdparty-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description"> Links to all outside sites are provided as a reference for our visitors. 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