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data-history-node-id="13" role="article" about="/how-amvuttra-may-help/results-with-amvuttra" class="node node--basic-page-with-sections --view-mode--full"> <div class="node__content"> <div class="sections basic_page_with_sections__item"> <div class="sections__item --image"> <div class="image-mobile1"> <div class="image-mobile1__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/3.1-hero-mb.jpg" width="750" height="390" alt="Steve, treated with AMVUTTRA®" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/3.1-hero-dt.png" width="2760" height="540" alt="Steve, treated with AMVUTTRA®" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> <div class="text"> <div class="text__item"><p>“After a discussion with my doctor, I thought AMVUTTRA<sup>®</sup> would be the best treatment for me.”</p><span class="name">—STEVE</span>, treated with AMVUTTRA</div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --title"> <div class="title"> <div class="title__item">How did AMVUTTRA® help patients in the study?</div> </div> </div> <div class="blocks__item --large_text"> <h1 style="height:1px;overflow:hidden;">Results With AMVUTTRA</h1> <p>Patients treated with AMVUTTRA <strong>showed significant improvement in nerve function and quality of life</strong> at 9 months, and continued to improve throughout an 18-month study of 164 adult patients, while those who received placebo in a similar study had worse nerve function and quality of life.</p> </div> <div class="blocks__item --large_text"> <div style="position: relative;"> <p id="nerve-function" style="clip-path: polygon(0% 0%, 0% 0%, 0% 0%);height: 1px;position: absolute;bottom: 0px;">Nerve function</p> <p id="qol-section" style="clip-path: polygon(0% 0%, 0% 0%, 0% 0%);height: 1px;position: absolute;bottom: 0px;">Quality of Life/p></p> </div> </div> <div class="blocks__item --tab_panel"><h2 class="top-text">Choose below to see:</h2> <div class="tabs animated-tabs" data-active-tab="1"> <div class="animate"> <div class="animate__item --image"> <div class="image-mobile1"> <div class="image-mobile1__item"> <div class="media media--svg --view-mode--full"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" id="svg-2-3-tab-nerve-function-mb" viewBox="0 0 315 62" shape-rendering="geometricPrecision" text-rendering="geometricPrecision" width="315" height="62"><rect id="svg-2-3-tab-nerve-function-mb-purple_tab" width="160" height="62" rx="0" ry="0" fill="#ffffff"/><g id="svg-2-3-tab-nerve-function-mb-g1" 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</div> </div> </div> </div> </div> </div> <div class="tab-link active" data-target="1"> Nerve function </div> <div class="tab-link" data-target="2"> Quality of life </div> </div> <div class="panels"> <div class="panel active" data-panel="1"> <div class="inner-container"> <div class="--container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/3.1-improved-nerve-function.png" width="625" height="429" alt="Amvuttra v Placebo" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <p>At 9 months, <strong>AMVUTTRA significantly improved nerve function</strong> while patients who received placebo had worse nerve function.</p> </div> </div> </div> <div class="--container_block"> <div class="blocks"> <div class="blocks__item --large_text"> <p>At 18 months, <strong>48%</strong> of patients who received AMVUTTRA <strong>regained some nerve function</strong> from the start of treatment while <strong>4% of those who received placebo</strong> regained some nerve function.</p> <ul><li>For the patients who received AMVUTTRA and did not regain some nerve function, <strong>progression of their neuropathy was slowed</strong> while the neuropathy of those who received placebo worsened</li> </ul> </div> </div> </div> <div class="--large_text"> <p><strong>Nerve function</strong> was assessed using a scale called mNIS+7 that measured strength and sensation in the hands, feet, arms, and legs; reflexes; and blood pressure upon standing.</p> </div> </div> </div> <div class="panel " data-panel="2"> <div class="inner-container"> <div class="--container_block"> <div class="blocks"> <div class="blocks__item --image"> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/3.1-improved-nerve-function.png" width="625" height="429" alt="Amvuttra v Placebo" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> <div class="blocks__item --large_text"> <p>At 9 months, <strong>AMVUTTRA significantly improved quality of life</strong> while patients who received placebo had a worse quality of life.</p> </div> </div> </div> <div class="--container_block"> <div class="blocks"> <div class="blocks__item --large_text"> <p>At 18 months, <strong>57%</strong> of patients who received AMVUTTRA <strong>reported better quality of life</strong> from the start of treatment, while <strong>10% of those who received placebo</strong> reported better quality of life.</p> </div> </div> </div> <div class="--large_text"> <p><strong>Quality of life</strong> was evaluated by the Norfolk QoL-DN questionnaire that asked patients about the severity of their polyneuropathy symptoms, how often they experienced them, and what impact they felt they had on their daily lives.</p> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --accordion"> <div class="title"> <div class="title__item">What other improvements did patients experience?</div> </div> <div class="large-text"> <div class="large-text__item"><p>The effects of AMVUTTRA on other aspects of the disease, including <strong>walking speed, nutritional health, and ability to perform activities of daily living,</strong> were also evaluated after 18 months and compared with the effects of placebo in a similar study.</p></div> </div> <div class="accordion-items" id=""> <div class="item"> <div class="header accordion-header flex justify-start items-center" tabindex="0" aria-label="Toggle accordion" aria-expanded="false"> <div class="image1"> <div class="image1__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div 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width="14" height="24" > </div> </div> <div class="body"> <div class="flex flex-col sm:flex-row"> <div class="large-text"> <div class="large-text__item"><h3>Patients treated with AMVUTTRA maintained a better walking speed, compared with patients who received placebo</h3> <ul><li>Evaluated using the 10-meter walk test, a stopwatch-timed measure of a patient’s walking speed over 10 meters</li> </ul></div> </div> </div> </div> </div> <div class="item"> <div class="header accordion-header flex justify-start items-center" tabindex="0" aria-label="Toggle accordion" aria-expanded="false"> <div class="image1"> <div class="image1__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Layer_1" x="0px" y="0px" viewBox="0 0 62 48" style="enable-background:new 0 0 62 48;" xml:space="preserve"> <style type="text/css"> 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received placebo</h3> <ul><li>Evaluated using modified body mass index, an assessment of height, weight, and the balance of fluids in the body, and was maintained with continued dosing at 18 months</li> </ul></div> </div> </div> </div> </div> <div class="item"> <div class="header accordion-header flex justify-start items-center" tabindex="0" aria-label="Toggle accordion" aria-expanded="false"> <div class="image1"> <div class="image1__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" id="Layer_1" x="0px" y="0px" viewBox="0 0 60 60" style="enable-background:new 0 0 60 60;" xml:space="preserve"> <style type="text/css"> .st-everday-activities-0{fill:#C9C5DA;} .st-everday-activities-1{fill:#4D4084;} </style> <g> <path class="st-everday-activities-0" 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living</div> </div> <div class="arrow"> <img src="/themes/amvuttra/src/images/0.0-icn-vertical-carrot-red-sm.svg" alt="Toggle item" width="14" height="24" > </div> </div> <div class="body"> <div class="flex flex-col sm:flex-row"> <div class="large-text"> <div class="large-text__item"><h3>Patients treated with AMVUTTRA were better able to perform common daily activities compared with patients who received placebo</h3> <ul><li>Evaluated using a questionnaire called R-ODS to assess ability to perform activities</li> <li>Common daily activities included:</li> </ul><img alt="Showering, brushing teeth, dressing upper body, going shopping, doing the dishes, walking up a flight of stairs" class="activities-dt align-center" data-entity-type="file" data-entity-uuid="a2f1ee0d-7223-407b-8437-62aec2784124" src="/sites/default/files/inline-images/3.1-results-common-activities-dt_0.png" width="1362" height="192" loading="lazy" /><p> </p> <img alt="Perform daily activities, like showering, brushing teeth, dressing upper body, going shopping, doing the dishes, walking up a flight of stairs" class="activities-mb align-center" data-entity-type="file" data-entity-uuid="ac226770-eb96-4b9e-aed6-7e0c04778e6f" src="/sites/default/files/inline-images/3.1-results-common-activities-mb_0.png" width="468" height="658" loading="lazy" /></div> </div> </div> </div> </div> </div> </div> <div class="sections__item --big_blue_link"><a class="link" href="/possible-side-effects" title="Learn about possible side effects"> <span class="up-next">Up next</span> <span class="title text-right">Learn about possible side effects</span> <span class="arrow"> <svg cache-id="18a3c6d249ce44cbb9ffbddd8d1dc4b3" id="ePvaDMrUYOV1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" viewBox="0 0 34 34" shape-rendering="geometricPrecision" text-rendering="geometricPrecision" width="34" height="34"><rect width="34" height="34" rx="0" ry="0" fill="#4d4084"/><g id="ePvaDMrUYOV3" 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</a></div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h2>Important Safety Information and Indication</h2> <h3>Important Safety Information</h3> <h4>What are the most important things I should know about AMVUTTRA<sup>®</sup> (vutrisiran)?</h4> <p>AMVUTTRA can cause:</p> <ul><li> <h4>Low Vitamin A Levels</h4> <p>Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</p> <p>Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</p> </li> </ul><h4>What are the common side effects of AMVUTTRA?</h4> <p>The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</p> <p>These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</p> <h3>Indication</h3> <h4>What is AMVUTTRA?</h4> <p>AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</p> <h4>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h4> <div class="w-full text-center"><a class="for-hcp" href="https://www.amvuttrahcp.com">For healthcare providers</a></div></div> </div> </div> </div><div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --embed_block"> <div class="block"> <div class="block__item"><div id="block-isicontent" class="block-block-content:0a26fb4c-c9db-4f7e-9c83-83eee0fd1104"> <div class="body"> <div class="body__item"><div class="h1">Important Safety Information and Indication</div> <div class="h2">Important Safety Information</div> <div class="h3">What are the most important things I should know about AMVUTTRA® (vutrisiran)?</div> <div class="p">AMVUTTRA can cause:</div> <div class="ul"> <div class="li"> <div class="h3">Low Vitamin A Levels</div> <div class="p">Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</div> <div class="p">Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</div> </div> </div> <div class="h3">What are the common side effects of AMVUTTRA?</div> <div class="p">The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</div> <div class="p">These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</div> <div class="h2">Indication</div> <div class="h3">What is AMVUTTRA?</div> <div class="p">AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</div> <div class="h3">For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf">Prescribing Information</a>.</div> <div class="p"><a href="https://www.amvuttrahcp.com">For healthcare providers</a></div> </div> </div> </div> </div> </div> </div> <div class="paragraphs__item --container_block"> <div class="blocks"> <div class="blocks__item --link"> <div class="link"> <div class="link__item"><a href="/stay-informed">Stay Informed</a></div> </div> </div> <div class="blocks__item --link_icon"><a class="link" href="https://www.amvuttrahcp.com" title="For healthcare providers" > For healthcare providers <div class="image-default"> <div class="image-default__item"> <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <span class="svg-title" aria-hidden="true">Go to page icon</span> <svg xmlns="http://www.w3.org/2000/svg" width="15.811" height="15.811" viewBox="0 0 15.811 15.811"><g transform="translate(0.75 1.061)"><path d="M6.125,0H1.75A1.75,1.75,0,0,0,0,1.75V9.625a1.75,1.75,0,0,0,1.75,1.75H9.625a1.75,1.75,0,0,0,1.75-1.75V5.25" transform="translate(0 2.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,8.75,8.75,0" transform="translate(5.25 0)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/><path d="M0,0H4.375V4.375" transform="translate(9.625)" fill="none" stroke="#e7004c" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="1.5"/></g></svg> </div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div>  <div class="fixed hidden inset-0 overflow-y-auto h-full w-full items-start md:items-center" id="modals-overflow">  <div class="modal" id="welcome-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">The site you are about to enter is intended for US healthcare professionals.</h2> <p class="description">Are you a US healthcare professional?</p> <a href="#" tabindex="1" class="confirm-btn" data-modal-target="1"> Confirm and enter <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn icon-link-external-right" href="#" data-modal-target="1">Visit patient site</a> </div> </div> </div> <div class="modal" id="corporative-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description">You are now being directed to another Alnylam website.</p> <a class="confirm-btn" href="#" target="_blank" data-modal-target="2"> Proceed <svg class="inline" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" width="18px" height="18px" viewBox="0 0 20 20" style="enable-background:new 0 0 20 20;" xml:space="preserve"> <path class="st0" d="M18.995,10c0-0.282-0.118-0.534-0.306-0.716l-7.019-7.018c-0.391-0.391-1.023-0.391-1.414,0 s-0.391,1.023,0,1.414L15.577,9H1.595c-0.552,0-1,0.448-1,1s0.448,1,1,1h13.982l-5.32,5.319c-0.391,0.391-0.391,1.023,0,1.414 c0.195,0.195,0.451,0.293,0.707,0.293s0.512-0.098,0.707-0.293l7.019-7.018C18.878,10.534,18.995,10.281,18.995,10z" /> </svg> </a> <a tabindex="2" class="close-btn" href="#" data-modal-target="2">Cancel</a> </div> </div> </div> <div class="modal" id="thirdparty-popup"> <div class="modal-body px-4"> <div class="logo"> <img src="/themes/amvuttra/logo.svg" alt="AMVUTTRA™ (vutrisiran) logo"> </div> <div class="content"> <h2 class="title">You are now leaving amvuttra.com.</h2> <p class="description"> Links to all outside sites are provided as a reference for our visitors. 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