Saul Villeda, PhD - American Federation for Aging Research

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section--padxs-bottom section--bgclr color-green section--bgimg"> <div class="section__bg section__bg--img poster inlay__bg--block-612929"></div> <style> .inlay__bg--block-612929 { background-image: url(/imager/sciencebackgroundphotos/313958/AFAR-Molecules_10_Floating_Right_White_b616f0dd1c9e12ac293f80067c1526ee.jpg); } @media (max-width: 1024px) { .inlay__bg--block-612929 { background-image: url(/imager/sciencebackgroundphotos/313958/AFAR-Molecules_10_Floating_Right_White_775dfc64901f4612608e87a7497e295b.jpg); } } @media (max-width: 480px) { .inlay__bg--block-612929 { background-image: url(/imager/sciencebackgroundphotos/313958/AFAR-Molecules_10_Floating_Right_White_4de3145e4a5f7b68a5e3a7333ae49011.jpg); } } </style> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad "> <div class="shell"> <div class="grid grid--sm"> <div class="grid__inner grid__inner--two-columns"> <div class="grid-item grid-item--three-forths grid-item--card-wide"> <div class="component component--inherit "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <h5>Grantee Spotlight Interview</h5><h1>Saul Villeda, PhD</h1><p>Associate Professor, University of California, San Francisco<br /><strong>McKnight Brain Research Foundation Innovator Awards in Cognitive Aging and Memory Loss </strong><strong>- 2021</strong></p> </div> </div> </div> </div> </div> </div> </div> <div class="grid-item grid-item--one-forth grid-item--card-wide"> <div class="component component--inherit"> <div class="photo"> <div class="photo__inner"> <div class="photo__image"> <img class="lazyload" data-src="/imager/general/612820/Villeda-Headshot_8c3db02c789aac09497d19c3bbf7ce48.jpg" alt="Villeda Headshot"> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_62" data-name="Path 62" d="M11651-12341l24,32-24,32" transform="translate(11677.5 -12275.801) rotate(180)" fill="none" stroke="currentColor" stroke-width="4"> </path></svg> </span> </div> <div class="slider__arrow slider__next swiper-button-next component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="28.1" height="66.398" viewBox="0 0 28.1 66.398"> <path id="Path_63" data-name="Path 63" d="M11651-12341l24,32-24,32" transform="translate(-11649.4 12342.199)" fill="none" stroke="currentColor" stroke-width="4"></path> </svg> </span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section section--padxs-top section--padxs-bottom "> <div class="section__bg section__bg--clr"></div> <div class="section__inner section__pad"> <div class="shell"> <div class="grid grid--xs"> <div class="grid__inner"> <div class="grid-item grid-item--full"> <div class="component "> <div class="inlay"> <div class="shadow"></div> <div class="inlay__bg inlay__bg--clr component__bgclr"></div> <div class="inlay__inner"> <div class="article color-blue"> <div class="article__inner component__cols"> <div class="article__main" data-aos="fade-up"> <p><strong>What inspired you to pursue aging research?</strong></p><p>My interest in the fields of aging and rejuvenation is grounded in my fascination with development and tissue plasticity. The initial spark that led me to this field came as an undergraduate when I first learned about the discovery of the Spemann organizer. In this study, performed almost 100 years ago, scientists transplanted a small portion of a newt embryo onto another and induced organismal changes that resulted in the formation of a twin embryo. This fundamental concept that organismal changes could be influenced by inter-tissue interactions has molded my research program. Could latent plasticity remaining at old age mirror plasticity observed in development to rejuvenate aging tissues? </p><p><strong>In your view, what does AFAR mean to the field, and what does it mean, for you, to receive an AFAR grant now?</strong></p><p>AFAR serves as both the nexus and launching pad for the biology of aging research field. AFAR provides a mechanism in which innovative and oftentimes high-risk high-reward research is supported at the very early stages. To me, receiving an AFAR grant represents both validation and encouragement to pursue areas of research in which we seek to develop therapeutics that can treat cognitive decline in the aging brain by targeting molecular mechanisms of aging in blood independent of the brain itself.</p><p><strong>What is exciting about your research’s potential impact?</strong></p><p>The proposed research aims to challenge long-standing views of brain aging as a rigid process, by identifying caloric restriction-induced blood factors as molecular targets to delay and potentially reverse age-related cognitive decline. The ability to counter brain aging through blood-based therapeutic interventions could enable the mitigation of vulnerability to dementia-related disorders in the elderly, fulfilling an unmet need that is growing more pressing as the human population ages. </p><p><strong>How would you describe your research to a non-scientist?</strong></p><p>My research is focused on understanding what drives functional and cognitive impairments in the aging brain, and importantly how the effects of aging can be reversed in the old brain. We focus our investigations on the beneficial effects of systemic interventions - including young blood administration, exercise, and caloric restriction – in animal models of brain aging. Our goal is to identify therapeutic targets in blood to prevent, ameliorate and reverse dementia-related neurodegenerative diseases in the elderly. </p><p><strong>AFAR turned 40 in 2021. What is your vision for the next 40 years of healthy aging? </strong></p><p>I turned 40 in 2021 too! My vision for the next 40 years of healthy aging involves the translation of lifestyle interventions, such as exercise and caloric restriction, into tractable therapeutic targets that can not only delay but restore function late in life. Given the unique trajectory for each aging individual, I believe decoding broad lifestyle interventions into combinatorial sets of molecular targets will enable a personalized medicine approach in which individual hallmarks of aging specific to each person can be ameliorated. </p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="section"> <div class="section__inner section__pad"> <div class="shell"> <div class="more-content-title"> <h2>More Grantee Spotlight Interviews</h2> </div> </div> </div> </div> <div class="section section--padxs-top section--padsm-bottom slider"> <div class="section__inner section__pad"> <div class="slider__inner"> <div class="shell"> <div class="grid swiper-container js-slider"> <div class="grid__inner swiper-wrapper slider__slides"> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Ana Daugherty</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2023</h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/ana-daugherty-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746167/Daugherty-Headshot_8c9f4034d45e49a8e70c8b471fce2dcf.jpg" alt="Ana Daugherty"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/ana-daugherty-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Jude Phillip</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2023</h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/jude-phillip-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746184/Phillip-Headshot_12fec0858df9e8af9b485b2f528398e2.png" alt="Jude Phillip"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/jude-phillip-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Caitlin Davis</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research - 2023 </h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/caitlin-davis-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/granteeprofileimages/773568/Davis-Headshot_1cd66a754a55febef2e5e916bb146edf.jpg" alt="Caitlin Davis"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/caitlin-davis-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Sreemathi Logan</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research - 2023 </h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/sreemathi-logan-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/granteeprofileimages/773535/Logan-Headshot_8a38644c0146fad98e5d60944c4077cc.png" alt="Sreemathi Logan"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/sreemathi-logan-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Timothy Rhoads</h5> <p><small><em>March 12, 2024</em></small></p> <h4>The Sagol Network GerOmic Award for Junior Faculty - 2023 </h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/timothy-rhoads" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746204/Rhoads-Headshot_bbe9ae3df5b14ea5eeb45536f9314a28.jpg" alt="Timothy Rhoads"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/timothy-rhoads" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Jiping Yang</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research - 2023 </h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/jiping-yang" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746301/Yang-Headshot_9fe8a25ca44a6fa5979b2229a9152181.jpeg" alt="Jiping Yang"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/jiping-yang" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Hilary Grosso Jasutkar</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2023</h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/hilary-grosso-jasutkar-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746171/Jasutkar-Headshot_83d39b5f812eb273970834eb0baa1aa1.jpg" alt="Hilary Grosso Jasutkar"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/hilary-grosso-jasutkar-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Jesscia Spinelli</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty - 2023</h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/jesscia-spinelli-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/general/746188/Spinelli-Headshot_b45c9ae1545e889085e37e5acaccf264.jpg" alt="Jesscia Spinelli"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/jesscia-spinelli-spotlight" class="card__link component__link"></a> </div> </div> </div> <div class="grid-item slider__slide swiper-slide"> <div class="component component--separator"> <div class="card card--index"> <div class="shadow"></div> <div class="card__image"> <div class="separator component--separator color-yellow"></div> </div> <div class="card__inner"> <div class="card__content"> <h5>Jason DeFreitas</h5> <p><small><em>March 12, 2024</em></small></p> <h4>Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research - 2023 </h4> </div> <div class="card__actions component__actions"> <a href="https://www.afar.org/grantee-spotlight-interviews/jason-defreitas-spotlight" class="color-yellow">Read Interview</a> </div> <div class="card__image-inline"> <img class="lazyload slider__image" data-src="/imager/granteeprofileimages/773564/DeFreitas-Headshot_161ed30778f59f711d1690d7ef7ea098.jpg" alt="Jason DeFreitas"> </div> </div> <a href="https://www.afar.org/grantee-spotlight-interviews/jason-defreitas-spotlight" class="card__link component__link"></a> </div> </div> </div> </div> </div> <div class="slider-nav"> <div class="slider__arrow slider__prev swiper-button-prev component-arrow"> <span class="icon"> <svg xmlns="http://www.w3.org/2000/svg" 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Saul Villeda, PhD - American Federation for Aging Research