CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Martin Hauer-jensen - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="4kp8mV0Atd0ulPIy9Qpk35L8yCEUPy5FAzRBnCb02lSabCXnoRomZih9IXP1hS3gN6w61cD379ApOq7H5KjAcA" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-d1941ab08e91e29ee143084c4749da4aaffa350a2ac6eec2306b1d7a352d911a.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="martin hauer-jensen" /> <meta name="description" content="Director of Radiation Health at UAMS." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '29cbb9485f79f49ca3eb38b6f0905739256f19a4'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14022,"monthly_visitors":"104 million","monthly_visitor_count":104255865,"monthly_visitor_count_in_millions":104,"user_count":283564330,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1740388055000); window.Aedu.timeDifference = new Date().getTime() - 1740388055000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-1eb081e01ca8bc0c1b1d866df79d9eb4dd2c484e4beecf76e79a7806c72fee08.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-b42d48e01e9cb3bf5ae55ea154ab7133fe47240c1d7c59b0249065c67d6f65ab.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-f3fdf92d2e211a3fd7a717a75adb7bf4af30f5d7651964d9f223129f218112cd.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/MartinHauerjensen" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-6e7abecbfd0bf8149b30c67f14f697778b51c925ffaf0902383f452f4270c74f.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":303607,"name":"Epistemology of environmental sciences","url":"https://www.academia.edu/Documents/in/Epistemology_of_environmental_sciences"},{"id":21967,"name":"Ancient DNA (Archaeology)","url":"https://www.academia.edu/Documents/in/Ancient_DNA_Archaeology_"},{"id":13338,"name":"Invasion Ecology","url":"https://www.academia.edu/Documents/in/Invasion_Ecology"},{"id":4341,"name":"Transcriptomics","url":"https://www.academia.edu/Documents/in/Transcriptomics"},{"id":153569,"name":"Plant sciences","url":"https://www.academia.edu/Documents/in/Plant_sciences"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/MartinHauerjensen","location":"/MartinHauerjensen","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/MartinHauerjensen","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-836a0d78-6599-4fef-962b-d67dddb7270c"></div> <div id="ProfileCheckPaperUpdate-react-component-836a0d78-6599-4fef-962b-d67dddb7270c"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Martin Hauer-jensen</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Martin" data-follow-user-id="33653594" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="33653594"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">11</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-author</p><p class="data">1</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/MartinHauerjensen/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Director of Radiation Health at UAMS.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://tcd.academia.edu/JulianReynolds"><img class="profile-avatar u-positionAbsolute" alt="Julian D Reynolds" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/10761/3636/3596/s200_julian.reynolds.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://tcd.academia.edu/JulianReynolds">Julian D Reynolds</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Trinity College Dublin</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://klyuniv.academia.edu/JayjitMajumdar"><img class="profile-avatar u-positionAbsolute" alt="Jayjit Majumdar" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/30581/9917/54070/s200_jayjit.majumdar.30581" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://klyuniv.academia.edu/JayjitMajumdar">Jayjit Majumdar</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Kalyani</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ksu.academia.edu/DavidSeamon"><img class="profile-avatar u-positionAbsolute" alt="David Seamon" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/93547/25922/29662134/s200_david.seamon.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ksu.academia.edu/DavidSeamon">David Seamon</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Kansas State University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ucdavis.academia.edu/AlisonBerry"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ucdavis.academia.edu/AlisonBerry">Alison Berry</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of California, Davis</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://usf.academia.edu/ChristinaRichards"><img class="profile-avatar u-positionAbsolute" alt="Christina Richards" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/446356/144457/167907/s200_christina.richards.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://usf.academia.edu/ChristinaRichards">Christina Richards</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of South Florida</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://atree.academia.edu/AravindNA"><img class="profile-avatar u-positionAbsolute" alt="Aravind N.A." border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/570221/203617/237597/s200_aravind.n.a..jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://atree.academia.edu/AravindNA">Aravind N.A.</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Ashoka Trust for Research in Ecology and the Environment (ATREE)</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://eva-mpg.academia.edu/AlissaMittnik"><img class="profile-avatar u-positionAbsolute" alt="Alissa Mittnik" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/963339/2717598/16472628/s200_alissa.mittnik.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://eva-mpg.academia.edu/AlissaMittnik">Alissa Mittnik</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Max Planck Institute for Evolutionary Anthropology</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://su-se.academia.edu/ViacheslavKuleshov"><img class="profile-avatar u-positionAbsolute" alt="Viacheslav Kuleshov" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/1895779/1756649/167070895/s200_viacheslav.kuleshov.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://su-se.academia.edu/ViacheslavKuleshov">Viacheslav Kuleshov</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Stockholm University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://hms-harvard.academia.edu/JakobSedig"><img class="profile-avatar u-positionAbsolute" alt="Jakob Sedig" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/3441101/1168494/22140898/s200_jakob.sedig.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://hms-harvard.academia.edu/JakobSedig">Jakob Sedig</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Harvard Medical School</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://sinop.academia.edu/AhmetOzer"><img class="profile-avatar u-positionAbsolute" alt="Ahmet Ozer" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/4493176/1847369/80618698/s200_ahmet.ozer.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://sinop.academia.edu/AhmetOzer">Ahmet Ozer</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Sinop Üniversitesi</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33653594" href="https://www.academia.edu/Documents/in/Epistemology_of_environmental_sciences"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/MartinHauerjensen","location":"/MartinHauerjensen","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/MartinHauerjensen","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Epistemology of environmental sciences"]}" data-trace="false" data-dom-id="Pill-react-component-f23f5822-1689-4375-8a16-bcd303fdb898"></div> <div id="Pill-react-component-f23f5822-1689-4375-8a16-bcd303fdb898"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33653594" href="https://www.academia.edu/Documents/in/Ancient_DNA_Archaeology_"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Ancient DNA (Archaeology)"]}" data-trace="false" data-dom-id="Pill-react-component-5e93325f-ccb1-4e1a-9ab5-a45c57de0a8f"></div> <div id="Pill-react-component-5e93325f-ccb1-4e1a-9ab5-a45c57de0a8f"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33653594" href="https://www.academia.edu/Documents/in/Invasion_Ecology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Invasion Ecology"]}" data-trace="false" data-dom-id="Pill-react-component-90bb47f1-7f67-4a97-ab89-f8dfcf3fd7e5"></div> <div id="Pill-react-component-90bb47f1-7f67-4a97-ab89-f8dfcf3fd7e5"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33653594" href="https://www.academia.edu/Documents/in/Transcriptomics"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Transcriptomics"]}" data-trace="false" data-dom-id="Pill-react-component-e6145ded-d515-4c5b-83c0-8bdd447e0b12"></div> <div id="Pill-react-component-e6145ded-d515-4c5b-83c0-8bdd447e0b12"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="33653594" href="https://www.academia.edu/Documents/in/Plant_sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Plant sciences"]}" data-trace="false" data-dom-id="Pill-react-component-fa8988fc-2d9d-4b5d-ac26-495123cd60c5"></div> <div id="Pill-react-component-fa8988fc-2d9d-4b5d-ac26-495123cd60c5"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li><a class="ds2-5-text-link ds2-5-text-link--small" href="https://martinhauerjensen.academia.edu/"><span class="ds2-5-text-link__content"><i class="fa fa-laptop"></i></span></a></li><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Martin Hauer-jensen</h3></div><div class="js-work-strip profile--work_container" data-work-id="127218268"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism"><img alt="Research paper thumbnail of γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism" class="work-thumbnail" src="https://attachments.academia-assets.com/120984458/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism">γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism</a></div><div class="wp-workCard_item"><span>Radiation Research</span><span>, May 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analogs of vitamin E (tocols) are under development as radioprophylactic agents because of their ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analogs of vitamin E (tocols) are under development as radioprophylactic agents because of their high efficacy and lack of toxicity. Gamma-tocotrienol (GT3) is of particular interest because, in addition to being an antioxidant, it also inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and accumulates to greater extent in endothelial cells than other tocols. We addressed in vivo whether HMG-CoA reductase inhibition contributes to the radioprotection conferred by GT3. Groups of mice were treated with vehicle, mevalonate (the product of the reaction catalyzed by HMG-CoA reductase), GT3 alone or GT3 in combination with mevalonate. Lethality and standard parameters of injury to the hematopoietic, intestinal and vascular/ endothelial systems were assessed after exposure to total-body irradiation. GT3 improved postirradiation survival and decreased radiation-induced vascular oxidative stress, an effect that was reversible by mevalonate. GT3 also enhanced hematopoietic recovery, reduced intestinal radiation injury, and accelerated the recovery of soluble markers of endothelial function. These parameters were not reversed by mevalonate co-administration. Our data confirm GT3's radioprophylactic properties against hematopoietic injury and, for the first time, demonstrate benefits in terms of protection against gastrointestinal and vascular injury. The radioprotective efficacy of GT3 against vascular injury is related to its properties as an HMG-CoA reductase inhibitor.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ee61e41dd32a856ba65bb0a90a9eb1ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":120984458,"asset_id":127218268,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/120984458/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="127218268"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="127218268"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 127218268; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=127218268]").text(description); $(".js-view-count[data-work-id=127218268]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 127218268; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='127218268']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ee61e41dd32a856ba65bb0a90a9eb1ea" } } $('.js-work-strip[data-work-id=127218268]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":127218268,"title":"γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism","internal_url":"https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":120984458,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/120984458/thumbnails/1.jpg","file_name":"pmc2713014.pdf","download_url":"https://www.academia.edu/attachments/120984458/download_file","bulk_download_file_name":"Tocotrienol_Ameliorates_Intestinal_Rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/120984458/pmc2713014-libre.pdf?1737675669=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_Ameliorates_Intestinal_Rad.pdf\u0026Expires=1740391655\u0026Signature=ZkCofkufEryRQ0FTdln5p7d5cD40M926Z6HsAHx~C5oJ-a~Vl7stuasmKBbG9A9AbfGgKpjRVIi7ISX7g6RxVb8OpYH32mQt4DHdClYW1dcjtHRDm63RYyUxzbyzzjqeRXEXLnGp-VsWLF0oRnNSbxOKLIcie3zj-UsATnI3uODfxs6Ghmx9H2jnT5P27mwXaHPkH7WE5J0QhcfJEHtdic0AWOK-iWkAGO7EOF3vgDAj-eQMvPcjY-hSY9LRLiDgdM06xPI6OLVCsUVbAL70qibwrstet~keSBooSWb~GF8fbJ8O3dTrbM0WP616hFKgAId7ezhz3dC81iBWDLGbxg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":120984457,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/120984457/thumbnails/1.jpg","file_name":"pmc2713014.pdf","download_url":"https://www.academia.edu/attachments/120984457/download_file","bulk_download_file_name":"Tocotrienol_Ameliorates_Intestinal_Rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/120984457/pmc2713014-libre.pdf?1737675674=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_Ameliorates_Intestinal_Rad.pdf\u0026Expires=1740391655\u0026Signature=Klnb~Uqfy30c8rkJEbd-MnTgKhIKRet0r2IQbkvixoeMImR7VYp593MblKM~2yvQb4QQv76KPKl9DjVUE3qal-2R2p0cVQJBCjd-LnqpwvWVN7ZzJgxIbZ7LkmobpoIzlygexRkDmcHeNlruHFF35GCCv5claSiB2RrnSnK6C-jTAN1LFqMNg0EhiWbszTeQh5-hyunE--v9NqtelKALTFv8wE8Zq4oiE1O6f9dh4RuHAN678t0xY37RkdbXOxFTho5EzwJLew2YPyL6vN7Ol~1SOnsG8-1PNphesb8aclH0XDHjHN9JOysn2NJyQxjSZwbo107MmTDVgbV5udsBNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124689624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine"><img alt="Research paper thumbnail of Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine" class="work-thumbnail" src="https://attachments.academia-assets.com/118868787/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine">Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine</a></div><div class="wp-workCard_item"><span>Antioxidants & Redox Signaling</span><span>, Mar 20, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The biological effects of ionizing radiation (IR) from environmental, medical, and man-made sourc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The biological effects of ionizing radiation (IR) from environmental, medical, and man-made sources, as well as from space exploration are of broad health concern. During the last 40 years it has become evident that, in addition to short-lived free radical-mediated events initiated within microseconds of exposure and generally thought to dissipate within milliseconds, IR-induced production of reactive oxygen and nitrogen species as well as changes in redox signaling linked to disruption of metabolic processes persist long after radiation exposure. Furthermore, persistent IR-induced increases in the metabolic production of reactive oxygen and nitrogen species appear to significantly contribute to the delayed effects of IR exposure, including induction of adaptive responses at low doses as well as carcinogenesis, fibrosis, inflammation, genomic instability, and acceleration of the onset of degenerative tissue injury processes associated with aging. The ability to identify the specific metabolic mechanisms and dose-response relationships that contribute to adaptive responses as well as persistent IR-induced injury processes holds great promise for identifying novel strategies to mitigate the deleterious effects of IR exposure as well as for gathering mechanistic information critical for risk assessment. This Forum contains original and review articles authored by experts in the field of radiobiology focusing on novel mechanisms involving redox biology and metabolism that significantly contribute to the persistent biological effects seen following IR exposure. Antioxid. Redox Signal. 20, 1407-1409.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="972c5310f57003c4e2451fe68a380119" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118868787,"asset_id":124689624,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118868787/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124689624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124689624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124689624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124689624]").text(description); $(".js-view-count[data-work-id=124689624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124689624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124689624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "972c5310f57003c4e2451fe68a380119" } } $('.js-work-strip[data-work-id=124689624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124689624,"title":"Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine","internal_url":"https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":118868787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118868787/thumbnails/1.jpg","file_name":"pmc3936498.pdf","download_url":"https://www.academia.edu/attachments/118868787/download_file","bulk_download_file_name":"Ionizing_Radiation_Induced_Responses_Whe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118868787/pmc3936498-libre.pdf?1728860500=\u0026response-content-disposition=attachment%3B+filename%3DIonizing_Radiation_Induced_Responses_Whe.pdf\u0026Expires=1740391655\u0026Signature=J8IE42S~v5i0MO-uhmuaGU9BqjTLUVYSwfPO4qtNCwvCcd57W~WyC-52EWbn65xJF-C8zqady16yW~h0PTaxBzLoQy800x~EctK0PVE5Hgp7dPol6vgQKwRacqJuPYATd-PYQ-DkAhjtFOtMJNy5~K2A0AL8c9ivAyBXHbf9vnLyhtOTzL6DYhizWgkU6yGA4UWOD-x~lhTkoGhG81iF2EHBKS-qRPd0Kb6QEacYP-K9icLGDaGc0T2om4ZoulyNf054TBVfSRx3otgaYvhPO4fA9uy6NISb4Pv-OaGD9PVw5P7CVLKqueJMgKg9fXONNn71ntnqP-vxTYlaDJfokA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":118868788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118868788/thumbnails/1.jpg","file_name":"pmc3936498.pdf","download_url":"https://www.academia.edu/attachments/118868788/download_file","bulk_download_file_name":"Ionizing_Radiation_Induced_Responses_Whe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118868788/pmc3936498-libre.pdf?1728860502=\u0026response-content-disposition=attachment%3B+filename%3DIonizing_Radiation_Induced_Responses_Whe.pdf\u0026Expires=1740391655\u0026Signature=HsRwVWCDPwwA1qbjW4~SrwE7ZnVOfSml6bor7S3zA~JRNmxj2u44wDYrFb1WEFoFYtr5NpzoReWPS4E-jCXsdJCGvdeYE0ulYfsqnb19go41EL~cb6r7zUjchwNjIfbczG0D39AdnO5mZx8O~LPrJuE~9updd1kMazlAnZum0Z2xUCOynhNYJzH97Eu5qnbbE6kJKatDwelh3RoWdwF9MZD~9r2AXrDwN~4HaUf4rPA-VmJuC~5pWdhaW1gGpDCML1I~P31GQg5pL7rHg67xApV5tGd--heJP~-X-nbVthFQi3abXVTSw1UQLVFEU5XES3NnZNugvF7kJtgdItDJDQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043046"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells"><img alt="Research paper thumbnail of Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells" class="work-thumbnail" src="https://attachments.academia-assets.com/116784447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells">Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells</a></div><div class="wp-workCard_item"><span>Differentiation</span><span>, Sep 1, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Induced pluripotent stem (iPS) cells are derived from reprogrammed somatic cells and are similar ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Induced pluripotent stem (iPS) cells are derived from reprogrammed somatic cells and are similar to embryonic stem (ES) cells in morphology, gene/protein expression, and pluripotency. In this study, we explored the potential of iPS cells to differentiate into alveolar Type II (ATII)-like epithelial cells. Analysis using quantitative real time polymerase chain reaction and immunofluorescence staining showed that pulmonary surfactant proteins commonly expressed by ATII cells such as surfactant protein A (SPA), surfactant protein B (SPB), and surfactant protein C (SPC) were upregulated in the differentiated cells. Microphilopodia characteristics and lamellar bodies were observed by transmission electron microscopy and lipid deposits were verified by Nile Red and Periodic Acid Schiff staining. C3 complement protein, a specific feature of ATII cells, was present at high levels in culture supernatants demonstrating functionality of these cells in culture. These data show that the differentiated cells generated from iPS cells using a culture method developed previously (Rippon et al., 2006) are ATII-like cells. To further characterize these ATII-like cells, we tested whether they could undergo epithelial to mesenchymal transition (EMT) by exposure to drugs that induce lung fibrosis in mice, such as bleomycin, and the combination of transforming growth factor beta1 (TGF b1) and epidermal growth factor (EGF). When the ATII-like cells were exposed to either bleomycin or a TGF b1-EGF cocktail, they underwent phenotypic changes including acquisition of a mesenchymal/fibroblastic morphology, upregulation of mesenchymal markers (Col1, Vim, a-Sma, and S100A4), and downregulation of surfactant proteins and E-cadherin. We have shown that ATII-like cells can be derived from skin fibroblasts and that they respond to fibrotic stimuli. These cells provide a valuable tool for screening of agents that can potentially ameliorate or prevent diseases involving lung fibrosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8979fd08f36e0e7813eb617f98cf4ae2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784447,"asset_id":122043046,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043046"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043046; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043046]").text(description); $(".js-view-count[data-work-id=122043046]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043046; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043046']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8979fd08f36e0e7813eb617f98cf4ae2" } } $('.js-work-strip[data-work-id=122043046]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043046,"title":"Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells","internal_url":"https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784447/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/116784447/download_file","bulk_download_file_name":"Epithelial_to_mesenchymal_transition_EMT.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784447/viewcontent-libre.pdf?1720980930=\u0026response-content-disposition=attachment%3B+filename%3DEpithelial_to_mesenchymal_transition_EMT.pdf\u0026Expires=1740391655\u0026Signature=RQq54thGUqh3Zn6JeHY4mB8oh57u7o0iCeaU0oYIWIaerPegUlrA~EkDIHWeCeBpzbNsOa9w7aV4AN6MOjMMryTdQIdGeZiivn6QWZa1KcT28V1~-XTgmn~dwdgHLDhO5~l5ZkgNN0mmny~oaA7rl0OVzdAt9S9nJKmjEC9-lrnUHXMKscmNMyDqeVwW7XIJqhdqgUjg7GvjTgyJehBeowWu0EGk3uTpWexzedTmOA0L3UzIYzhp3SSS~VwviTV9uxpi1UxKutuleLUnvhoDzJZLaR54ajt1ompt-YDYzL7gwgB6zMep5N2JMYDM9nVuoEYwXNOqCn42xAoi9D05QQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784448,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784448/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/116784448/download_file","bulk_download_file_name":"Epithelial_to_mesenchymal_transition_EMT.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784448/viewcontent-libre.pdf?1720980934=\u0026response-content-disposition=attachment%3B+filename%3DEpithelial_to_mesenchymal_transition_EMT.pdf\u0026Expires=1740391655\u0026Signature=cNDWO3teZWL5JN9vbo83GpBVf5KrtkBNkR5xOvRfpaHQ43h7-bWeJeo~7GymClynYloEThuYq7cxsjyv~3oHX0lxGKlGKAAelFniZ1xJ9LWbX7SJ1I6LRi1OONMyXkRYJmNJuhIf9Z6sCx4y6IAh-HAThtR9l0njCwnb5GvCWgP2N7C5U6oj~PMHNXvwFJf1i~wVBIqPUHqUAvGTbYUuhdMr~4df3CtHabMqbce5vJ~z4cAdUYH90M1iNV4XYSW3oJdLxmSaPp6w-svZ6Zsjf0nPT-Q2EZ-epYfioMkxBY-jz19haRtu5AHN7BNETipVad47W9xyWHyoTFiBHg6Kbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model"><img alt="Research paper thumbnail of Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model" class="work-thumbnail" src="https://attachments.academia-assets.com/116784446/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model">Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no radioprotectors available to mitigate hematopoietic injury after radiation exposure. Gamma-tocotrienol (GT3) has demonstrated promising radioprotective efficacy in the mouse and nonhuman primate (NHP) models. We determined GT3-mediated hematopoietic recovery in total-body irradiated (TBI) NHPs. Sixteen rhesus macaques divided into two groups received either vehicle or GT3, 24 h prior to TBI. Four animals in each treatment group were exposed to either 4 or 5.8 Gy TBI. Flow cytometry was used to immunophenotype the bone marrow (BM) lymphoid cell populations, while clonogenic ability of hematopoietic stem cells (HSCs) was assessed by colony forming unit (CFU) assays on day 8 prior to irradiation and days 2, 7, 14, and 30 post-irradiation. Both radiation doses showed significant changes in the frequencies of B and T-cell subsets, including the self-renewable capacity of HSCs. Importantly, GT3...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a44813704ff3bd4cdff7c90a660d0884" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784446,"asset_id":122043045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784446/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043045]").text(description); $(".js-view-count[data-work-id=122043045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a44813704ff3bd4cdff7c90a660d0884" } } $('.js-work-strip[data-work-id=122043045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043045,"title":"Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model","internal_url":"https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784446,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784446/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784446/download_file","bulk_download_file_name":"Gamma_Tocotrienol_Modulates_Total_Body_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784446/pdf-libre.pdf?1720980947=\u0026response-content-disposition=attachment%3B+filename%3DGamma_Tocotrienol_Modulates_Total_Body_I.pdf\u0026Expires=1740391655\u0026Signature=DCSeFzRt3fI9Im~MbzIfokbnguxtcf0e0xrCa1Hc6F2Ednj3uW4IiPN3yUQGwbDiUNhdfMr2WGk1PyTqTO75Htiq3PJOzKDfztozpvvuv3JEb1QlsrgGjRgWALvq6mLJpQN~79Dp5fXTqET~YGUXcXbH5tTZvCXOCbvORzlyvCd78h6w1VXM9Haeg7iWFbfm8jXTqbEAAUl8ripoaQ9mmjhy-C4nywh6TrJDHyrA7ne6anSiQiZz8kAPLxgBNQWV4jYuqI78aXy80aUKzTzsAhZBKWReXPktbZxm6dB5FNJWWQ1x0k1w-QrmFCrF9~QbgL8eK7-94D8BQTsgvgnnoA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043044"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model"><img alt="Research paper thumbnail of Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model" class="work-thumbnail" src="https://attachments.academia-assets.com/116784444/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model">Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model</a></div><div class="wp-workCard_item"><span>Antioxidants</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Exposure to high doses of radiation, accidental or therapeutic, often results in gastrointestinal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Exposure to high doses of radiation, accidental or therapeutic, often results in gastrointestinal (GI) injury. To date, there are no therapies available to mitigate GI injury after radiation exposure. Gamma-tocotrienol (GT3) is a promising radioprotector under investigation in nonhuman primates (NHP). We have shown that GT3 has radioprotective function in intestinal epithelial and crypt cells in NHPs exposed to 12 Gy total-body irradiation (TBI). Here, we determined GT3 potential in accelerating the GI recovery in partial-body irradiated (PBI) NHPs using X-rays, sparing 5% bone marrow. Sixteen rhesus macaques were treated with either vehicle or GT3 24 h prior to 12 Gy PBI. Structural injuries and crypt survival were examined in proximal jejunum on days 4 and 7. Plasma citrulline was assessed using liquid chromatography–tandem mass spectrometry (LC-MS/MS). Crypt cell proliferation and apoptotic cell death were evaluated using Ki-67 and TUNEL staining. PBI significantly decreased muco...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c95bcc75a09d1302f805268ad5bc95ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784444,"asset_id":122043044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784444/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043044]").text(description); $(".js-view-count[data-work-id=122043044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c95bcc75a09d1302f805268ad5bc95ec" } } $('.js-work-strip[data-work-id=122043044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043044,"title":"Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model","internal_url":"https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784444,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784444/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784444/download_file","bulk_download_file_name":"Effects_of_Gamma_Tocotrienol_on_Partial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784444/pdf-libre.pdf?1720980942=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Gamma_Tocotrienol_on_Partial.pdf\u0026Expires=1740391655\u0026Signature=RQ96U-0oEBAzJ1fbmS-wHc-sKPb~F7EM39U~8jTNSW4begrSRYmfqkCR247o3tO5SC5PRWtJTy-1WHD4guZKoH7uT2N5zIkBtRPNwuLC6BkBb~yO7NyBMX45T7RKg3j6tyF1xc~AFqoeCCtP-NjwmR7xkox2k6icnMrG4C~8LF5nH7ZhdPMkTKm1YsSge9B5kuMNFXb2GCg4N9PT6vg-o02ioNs~uxdb5~tQffbh3m~GVUo7JAXdrhJOMWydK2XQJyigbubas8mV6C2rHsTlmVyIvdbxUDMkTyx311IFw3fF3axuFGJEnGLeLKME5ph~Rbr-JnVmfyTra6-oqVvRpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784445,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784445/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784445/download_file","bulk_download_file_name":"Effects_of_Gamma_Tocotrienol_on_Partial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784445/pdf-libre.pdf?1720980943=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Gamma_Tocotrienol_on_Partial.pdf\u0026Expires=1740391655\u0026Signature=XCa3bxBq6pnliKzTTL2ZI4faeVSZwL-JUAOnUP8lXVH0jvjPXpRyZeWE12Q15LXIfQsw0zxxQlavw-Y8cJKZnLJP6qWSH8Elm3VuP08DT~exKTAYdoK0d~aO2K~aAteHLY5rbJR2xfCxjlYAexaLNdSSTl4PcHt5UwCn5mJsgvhyDYLsD7AowZk2AVcw9DtuJUnUNvE8DECDjiPSKnpp0JK3iwLodZx0dfFNlfnS9bAozNaxsS6Yw2uIpYBLil8fDp0Q5TIhkZWAH~p8s3h43DIwsQZ6jnYu7GjDfheXDSxwR~kKRr-5VMG4AYMAHE1aBRmg6MDUeFj1z9aGNsSAPA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043043"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure"><img alt="Research paper thumbnail of Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure" class="work-thumbnail" src="https://attachments.academia-assets.com/116784470/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure">Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure</a></div><div class="wp-workCard_item"><span>Metabolites</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependent changes in plasma metabolites in a nonhuman primate model of whole abdominal irradiation. Male and female adult Rhesus monkeys were exposed to 6 MV photons to the abdomen at doses ranging between 8 and 14 Gy. At time points from 1 to 60 days after irradiation, plasma samples were collected and subjected to untargeted metabolomics. With the limited sample size of females, different discovery times after irradiation between males and females were observed in metabolomics pattern. Detailed analyses are restricted to only males for the discovery power. Radiation caused an increase in fatty acid oxidation and circulating levels of corticosteroids which may be an indication of physiological stress, and amino acids, indicative of a cellular repair respo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a31a31e06176d9d9ab6892492ffbc5e1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784470,"asset_id":122043043,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784470/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043043"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043043"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043043; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043043]").text(description); $(".js-view-count[data-work-id=122043043]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043043; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043043']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a31a31e06176d9d9ab6892492ffbc5e1" } } $('.js-work-strip[data-work-id=122043043]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043043,"title":"Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure","internal_url":"https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784470,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784470/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784470/download_file","bulk_download_file_name":"Plasma_Metabolomics_in_a_Nonhuman_Primat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784470/pdf-libre.pdf?1720980929=\u0026response-content-disposition=attachment%3B+filename%3DPlasma_Metabolomics_in_a_Nonhuman_Primat.pdf\u0026Expires=1740391655\u0026Signature=TYhRLjM7x1cEBw-L9r9KLBqnnBfs9nFIJAjaS7xP7VSUC7CaUvEs8och7GY1J6R0u35vLKkVXRAcBXLpH8k~FJ59vMEwk8697BLK7~snSuqSP9hdKvblofzx2gxZNq5XPY4FcPMR5Qv6D6xV42zUcWTHIb6owZtKo8zpGOsZp-FxcjshN8KpqrZAtRO9YzIBOV9R50~8nXp~GBAcjdFCXImWIHvwdtMga7nKeAX20avyG0HfwOGsEHZGlNVnlLQkUN07DVN4HabO6JZtF3~yp7Gvtlkv8JfmRM7JFMf9~PwSiuJvLaWrZYGQMAoIRwCzzapAdGq4XZg~Q7Rcb-mGaA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043042"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells"><img alt="Research paper thumbnail of Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/116784443/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells">Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both cell and animal studies have shown that complete or partial deficiency of methionine inhibit...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Both cell and animal studies have shown that complete or partial deficiency of methionine inhibits tumor growth. Consequently, the potential implementation of this nutritional intervention has recently been of great interest for the treatment of cancer patients. Unfortunately, diet alteration can also affect healthy immune cells such as monocytes/macrophages and their precursor cells in bone marrow. As around half of cancer patients are treated with radiotherapy, the potential deleterious effect of dietary methionine deficiency on immune cells prior to and/or following irradiation needs to be evaluated. Therefore, we examined whether modulation of methionine content alters genetic stability in the murine RAW 264.7 monocyte/macrophage cell line in vitro by chromosomal analysis after 1-month culture in a methionine-deficient or supplemented medium. We also analyzed chromosomal aberrations in the bone marrow cells of CBA/J mice fed with methionine-deficient or supplemented diet for 2 m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f24f0334c31fed4765e436dafb11a89" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784443,"asset_id":122043042,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784443/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043042"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043042"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043042; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043042]").text(description); $(".js-view-count[data-work-id=122043042]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043042; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043042']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f24f0334c31fed4765e436dafb11a89" } } $('.js-work-strip[data-work-id=122043042]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043042,"title":"Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells","internal_url":"https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784443,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784443/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784443/download_file","bulk_download_file_name":"Dietary_Methionine_Deficiency_Enhances_G.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784443/pdf-libre.pdf?1720980938=\u0026response-content-disposition=attachment%3B+filename%3DDietary_Methionine_Deficiency_Enhances_G.pdf\u0026Expires=1740391655\u0026Signature=OpCuOri9N7JqqMiTWaaAuYz1-ck~Uk3Vwlt1NDZZi7hSBwyOUxvqZrvBXPu1hnt~vzFHOe1w2Lh1K~hf1Vike2fdhy3KROl3mvpG~Fw-4cq6ILitjbEJD8KlBFnXDJ1TMlS6tw5H7ubHnWst1VJ7qTu0iYt02lV4xUcUKTBCAoSkUIJGW31hscus-qI4DytfRsk9hYfLvweflqXG2H2LYIbZ29K-SkLkd6KzoY8moplYH8CmqHF1m9Nj0GMDYK7bCRwMf5F~G9F2Q55ruFssX3Q0YBTxJJIZ3BW412i0g2-FWGUxPTQmqknhUk0X3D5eIuX4GRttc1RNGoOLfrKPvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043041"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome"><img alt="Research paper thumbnail of Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/116784471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome">Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Gastrointestinal and Liver Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Methionine is an essential amino acid needed for a variety of processes in living organisms. Ioni...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Methionine is an essential amino acid needed for a variety of processes in living organisms. Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA methylation and decreased synthesis of glutathione. In this study, we aimed to investigate the effects of methionine dietary supplementation in CBA/CaJ mice after exposure to doses ranging from 3 to 8.5 Gy of 137Cs of total body irradiation. We report that mice fed a methionine-supplemented diet (MSD; 19.5 vs. 6.5 mg/kg in a methionine-adequate diet, MAD) developed acute radiation toxicity at doses as low as 3 Gy. Partial body irradiation performed with hindlimb shielding resulted in a 50% mortality rate in MSD-fed mice exposed to 8.5 Gy, suggesting prevalence of radiation-induced gastrointestinal syndrome in the development of acute radiation toxicity. Analysis of the intestinal microbiome demonstrated shifts in the gut ecology, observed along with the development of leaky gut syndrome and bacterial tr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4dd6cabda8c0243d85bf0318193df3a3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784471,"asset_id":122043041,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043041"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043041"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043041; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043041]").text(description); $(".js-view-count[data-work-id=122043041]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043041; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043041']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4dd6cabda8c0243d85bf0318193df3a3" } } $('.js-work-strip[data-work-id=122043041]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043041,"title":"Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome","internal_url":"https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784471/thumbnails/1.jpg","file_name":"ajpgi.00351.pdf","download_url":"https://www.academia.edu/attachments/116784471/download_file","bulk_download_file_name":"Methionine_dietary_supplementation_poten.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784471/ajpgi.00351-libre.pdf?1720980933=\u0026response-content-disposition=attachment%3B+filename%3DMethionine_dietary_supplementation_poten.pdf\u0026Expires=1740391655\u0026Signature=QLz~ZIcqS2LuM8ZE9WsiFLtNT4IDmyjjO98spT2ymXSHOjrrUCa~toMR9xQcgWlaackfKvXX5N2Y2UqXoxDLpyC19xGqUh5XzWjv8pf8nRVCMgQkCrAUVRO7Q6iqsop2dXbc9r6~Gl8ma6ha1hGLhd0l8RMaPRduinH3nffoBZKEfRSyZxVb7YDQ5Ni2HPo48bwela9v~q6agzC8d2UZQeNjzb3lV7w8JPtnbaePbYdo4R9lBzjsXVWlOdUkJCzvwiKpMbgT~d4~7OzREFk2MZY84hb1PqfwOeKGzcoKKfX~YEOl0RBlj5PWNWONtWKRe4bwOixYa5fw0~0xRIg4NQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043040"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress"><img alt="Research paper thumbnail of C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress" class="work-thumbnail" src="https://attachments.academia-assets.com/116784442/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress">C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress</a></div><div class="wp-workCard_item"><span>Scientific Reports</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt cells, intestinal barrier disruption and translocation of intestinal microflora resulting in sepsis-mediated lethality. We have shown that mice lacking C/EBPδ display IR-induced intestinal and hematopoietic injury and lethality. The purpose of this study was to investigate whether increased IR-induced inflammatory, oxidative and nitrosative stress promote intestinal injury and sepsis-mediated lethality in Cebpd−/− mice. We found that irradiated Cebpd−/− mice show decreased villous height, crypt depth, crypt to villi ratio and expression of the proliferation marker, proliferating cell nuclear antigen, indicative of intestinal injury. Cebpd−/− mice show increased expression of the pro-inflammatory cytokines (Il-6, Tnf-α) and chemokines (Cxcl1, Mcp-1, Mif-1α) and Nos2 in the intestinal tissues compared to Cebpd+/+ mice after exposure to TBI. Cebpd−/− mice show decreased GSH/GSSG ratio, incr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d7a7e6cce5d44ac4cd66707008d7137d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784442,"asset_id":122043040,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784442/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043040"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043040"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043040; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043040]").text(description); $(".js-view-count[data-work-id=122043040]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043040; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043040']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d7a7e6cce5d44ac4cd66707008d7137d" } } $('.js-work-strip[data-work-id=122043040]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043040,"title":"C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress","internal_url":"https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784442,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784442/thumbnails/1.jpg","file_name":"s41598-019-49437-x.pdf","download_url":"https://www.academia.edu/attachments/116784442/download_file","bulk_download_file_name":"C_EBP_protects_from_radiation_induced_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784442/s41598-019-49437-x-libre.pdf?1720980943=\u0026response-content-disposition=attachment%3B+filename%3DC_EBP_protects_from_radiation_induced_i.pdf\u0026Expires=1740391655\u0026Signature=RPQ2zmcf1Va~Ix1VYJhXnpYsSAHztTtL-7G0y2kTVhzLz~H85UzOBFEJn0Zv~M5JPQTCBDV8rxb2fM21aSWpA6dOOcZz77cYIyXWdJrEwcVfjOi8143zvrOBzI8YCmfOhDoPO~Kl0m4gtF7YCXf6qrzc5DiIwVJrfnua7m02Y6hVvjRb81VFuoVcYZ-y2tE4Qhn20njnxpsP89qgNYZAxzng65RVP-pXV6y8ev1H8c6ZxeYJrUTVQ1kk~2lfIA0hBDTw4tTmBalEIxzmDum8MCMzQBuBbxLtesuxPlDrMiHTpMXzWEYNlUS0EY8zc~1bEEQsKmW3-ufwWo9Y1gMw6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043039"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation"><img alt="Research paper thumbnail of Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation" class="work-thumbnail" src="https://attachments.academia-assets.com/116784439/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation">Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation</a></div><div class="wp-workCard_item"><span>Scientific Reports</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The human kidney embryonic 293 cell line (293 cells) is extensively used in biomedical and pharma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The human kidney embryonic 293 cell line (293 cells) is extensively used in biomedical and pharmaceutical research. These cells exhibit a number of numerical and structural chromosomal anomalies. However, the breakpoints responsible for these structural chromosomal rearrangements have not been comprehensively characterized. In addition, it is not known whether chromosomes with structural rearrangement are more sensitive to external toxic agents, such as ionizing radiation. We used G-banding, spectral karyotyping (SKY), and locus- and region-specific fluorescence in situ hybridization (FISH) probes designed in our lab or obtained from commercial vendor to address this gap. Our G-banding analysis revealed that the chromosome number varies from 66 to 71, with multiple rearrangements and partial additions and deletions. SKY analysis confirmed 3 consistent rearrangements, two simple and one complex in nature. Multicolor FISH analysis identified an array of breakpoints responsible for loc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d62f967dc0f3a6efb3291e4872e14d2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784439,"asset_id":122043039,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784439/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043039"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043039"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043039; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043039]").text(description); $(".js-view-count[data-work-id=122043039]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043039; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043039']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d62f967dc0f3a6efb3291e4872e14d2a" } } $('.js-work-strip[data-work-id=122043039]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043039,"title":"Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation","internal_url":"https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784439,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784439/thumbnails/1.jpg","file_name":"s41598-019-47002-0.pdf","download_url":"https://www.academia.edu/attachments/116784439/download_file","bulk_download_file_name":"Identification_of_novel_breakpoints_for.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784439/s41598-019-47002-0-libre.pdf?1720980941=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_novel_breakpoints_for.pdf\u0026Expires=1740391655\u0026Signature=Tq0StG~xElg6kGhyu0egaC893YwVDG4JQE26gYJsdB8EZZ-F2nbELPQMs2dHvGHDvzPfDgZa7ViFZtrlzKev-l2iCPzXHUnzUs-REUfuGxU~pS68MtdQ5c3Ps2ttdzMP2fvfuC308h1wHSEwHZUztmfMrNDF6dMK~zr6bor7u1FgsR4li9utbUOXj5RXnxiBnGx5u3TOWQvzQWfb9Pvzi9RoojcqT-gA6yLgQ5I45bIOcIANAI4hMzhBe~8uAxCSrmAfXxC44graDAEeA09vM3bke-D~shgHhKOfcnyXCYVHeLMouTeb0YFGjkKEDh1TG0TkrD6KLYqqrHcrjspUFw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784440,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784440/thumbnails/1.jpg","file_name":"s41598-019-47002-0.pdf","download_url":"https://www.academia.edu/attachments/116784440/download_file","bulk_download_file_name":"Identification_of_novel_breakpoints_for.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784440/s41598-019-47002-0-libre.pdf?1720980940=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_novel_breakpoints_for.pdf\u0026Expires=1740391655\u0026Signature=RR3nd1JpLZifoxpAM21ojIkZd5KlzXobzqRWMHt8qORsvblF4VifQPy7YD6h3EyFxNOeD9MrAEUdb7saEYvxV2~IxW~R7IWCPAvqNxDQal8rVj85y7vNhmQG0rj0QUeErTezE~ayP0LigFt7W8j6rR9S9xHsJXKoNj08JvQborKa57kg8ApStCbFQfVYN0biJOuuv73-xHp2pJOmQkGsKsYvfpNPWjOe7ahMm3YL1NAOioizhJLZ3HOSfYtA0rqWAk6Cv4hVUsfoq0RHm10RQYTRFNSZYVhU-Q6T6w0Kg3uEp3c494IrL4ezsi96Q246L-sRg2tVsozAQ1bLBtj1cA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043038"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery"><img alt="Research paper thumbnail of Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery" class="work-thumbnail" src="https://attachments.academia-assets.com/116784441/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery">Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery</a></div><div class="wp-workCard_item"><span>Antioxidants</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Natural antioxidant gamma-tocotrienol (GT3), a vitamin E family member, provides intestinal radia...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Natural antioxidant gamma-tocotrienol (GT3), a vitamin E family member, provides intestinal radiation protection. We seek to understand whether this protection is mediated via mucosal epithelial stem cells or sub-mucosal mesenchymal immune cells. Vehicle- or GT3-treated male CD2F1 mice were exposed to total body irradiation (TBI). Cell death was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Villus height and crypt depth were measured with computer-assisted software in tissue sections. Functional activity was determined with an intestinal permeability assay. Immune cell recovery was measured with immunohistochemistry and Western blot, and the regeneration of intestinal crypts was assessed with ex vivo organoid culture. A single dose of GT3 (200 mg/kg body weight (bwt)) administered 24 h before TBI suppressed cell death, prevented a decrease in villus height, increased crypt depth, attenuated intestinal permeability, and upregulated occludin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7711dd7ceb7f7a6a9a4bee6df671e945" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784441,"asset_id":122043038,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784441/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043038"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043038"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043038; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043038]").text(description); $(".js-view-count[data-work-id=122043038]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043038; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043038']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7711dd7ceb7f7a6a9a4bee6df671e945" } } $('.js-work-strip[data-work-id=122043038]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043038,"title":"Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery","internal_url":"https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784441,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784441/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784441/download_file","bulk_download_file_name":"Gamma_Tocotrienol_Protects_the_Intestine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784441/pdf-libre.pdf?1720980944=\u0026response-content-disposition=attachment%3B+filename%3DGamma_Tocotrienol_Protects_the_Intestine.pdf\u0026Expires=1740391655\u0026Signature=eg5vjcQkiiBLCDmdCPWpEw4qbDdHrgt8R84cinj6luupLZBpvKwArXnADUsW9otHoAVzLbVOgCGpVyJulYnTGmZ5wRTUJKMzUxIBtIGhkBnCEyEGgkkZk4ZeQjy-kKW5aTuO~TLMuT8KZSRBQXQDATmCcUvTYvRhTrcPXQ7GzJn70sGD-8DpDCePVpghjTDk31vXc3cRJ-axreONy8p623ZCL4Qq-HunUfV~lj6gWnLIcPyLguWqByj0dSd5JBHro0Urrg9XGxYwWO64zxHWiSGTUcu4dZ~MhYP8wOvmBz6StscT~ke6bYVUFXL8AIa6rt-9USV8VUvrkmvGUf0T1Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043037"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity"><img alt="Research paper thumbnail of NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/116784468/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity">NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose.-Growing rates of metabolic syndrome and associated obesity warrant the development of ap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose.-Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure. Materials and Methods.-We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (137 Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis. Results.-Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD 100/30 values at a dose of 8.5Gy. Alterations in the expression of various tight junction-related proteins coupled with activation of inflammatory responses and cell death were the main contributors to the gastrointestinal syndrome. Conclusions.-We demonstrate that metabolic syndrome with exhibited hyperglycemia but without alterations to the microvasculature is not a prerequisite of the increased sensitivity to TBI at high doses. Our studies indicate the potential of NZO/HlLtJ mice for the studies on the role of metabolic syndrome in acute radiation toxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d2485364659744520937a1f0cfcfbbc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784468,"asset_id":122043037,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784468/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043037"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043037"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043037; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043037]").text(description); $(".js-view-count[data-work-id=122043037]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043037; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043037']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d2485364659744520937a1f0cfcfbbc" } } $('.js-work-strip[data-work-id=122043037]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043037,"title":"NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity","internal_url":"https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784468,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784468/thumbnails/1.jpg","file_name":"pmc6581619.pdf","download_url":"https://www.academia.edu/attachments/116784468/download_file","bulk_download_file_name":"NZO_HlLtJ_as_a_novel_model_for_the_studi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784468/pmc6581619-libre.pdf?1720980928=\u0026response-content-disposition=attachment%3B+filename%3DNZO_HlLtJ_as_a_novel_model_for_the_studi.pdf\u0026Expires=1740391655\u0026Signature=Z3WLvAYTmmaEj0z7iXphSSnvVpMubDuJNQDcF1LJnj1JTV9pmGiMWiMohmoKUdhTaop-cB9D~86C0abUExvCcDbb~qWZaLr-K7QiDRIaBBNhdM3GzBdLvggI0SyZ02QAkjs--ln8mO3zSlH4uL57WCBy~yconWL~KwxrbLWM21~6~JD2NDQE2C~jkHTGG7mGveWk2pUcvz-kiiYF6jyzGzzGN4m2idC62gaR73TqVlXyOrh7i2XClef9jBsbkY1JV0~jbOn2eaXm00fqeGtYEZevkAL~4~DLqdITAO51mAD4JFoA5h6I9umHf5yb36YpCbplSa6v4MtaJuDQD64UVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043036"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine"><img alt="Research paper thumbnail of Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine">Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine</a></div><div class="wp-workCard_item"><span>Thrombosis and Haemostasis</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SummaryEndothelial dysfunction and increased platelet aggregation may be involved in the pathogen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SummaryEndothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy).Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-β1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR.Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased TGF-β1 expression. Clopidogrel reduced ADP-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043036"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043036"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043036; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043036]").text(description); $(".js-view-count[data-work-id=122043036]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043036; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043036']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043036]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043036,"title":"Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine","internal_url":"https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043035"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation"><img alt="Research paper thumbnail of Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation" class="work-thumbnail" src="https://attachments.academia-assets.com/116784469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation">Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation</a></div><div class="wp-workCard_item"><span>International journal of molecular sciences</span><span>, Jan 4, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements in mammalian genomes. LINE-1s are well-accepted as driving forces of evolution and critical regulators of the expression of genetic information. Alterations in LINE-1 DNA methylation may lead to its aberrant activity and are reported in virtually all human cancers and in experimental carcinogenesis. In this study, we investigated the endogenous DNA methylation status of the 5&#39; untranslated region (UTR) of LINE-1 elements in the bone marrow hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs), and mononuclear cells (MNCs) in radioresistant C57BL/6J and radiosensitive CBA/J mice and in response to ionizing radiation (IR). We demonstrated that basal levels of DNA methylation within the 5&#39;-UTRs of LINE-1 elements did not differ significantly between the two mouse strains and were negatively correlated with the evolutionary age of LINE-1 elements. Meanwhile, the expre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef083fb0e6cae081553ce2353a3fed99" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784469,"asset_id":122043035,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784469/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043035"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043035"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043035; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043035]").text(description); $(".js-view-count[data-work-id=122043035]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043035; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043035']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef083fb0e6cae081553ce2353a3fed99" } } $('.js-work-strip[data-work-id=122043035]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043035,"title":"Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation","internal_url":"https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784469/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784469/download_file","bulk_download_file_name":"Inter_Strain_Differences_in_LINE_1_DNA_M.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784469/pdf-libre.pdf?1720980930=\u0026response-content-disposition=attachment%3B+filename%3DInter_Strain_Differences_in_LINE_1_DNA_M.pdf\u0026Expires=1740391655\u0026Signature=VWIymDYpZHn3megBU3cFtu4pQsTDwGnidK38tntHiqpy9rqM6nrzZXdQGJZtztqlz43xgeOiDovR8rbs9NGtq8yUclGp-dPUNSx1g1belaOn3RqigFrPrGTELbpOIjTElStem2tZqjPWriy1YfJkVTg~kGKoBetqvNwpMQuBIuF7-XUGubAj-CqO6Sg9jluZ1iErqE42dnc5PhyZyH6sVp6Fu8JWVPOWmcZzvAtmosN7RTGPLRAWRS3G2h0eAdXJptpf~BKM9HZacFXu73fWguNWB0~09EeTwQY-SfvE6Q0IH7m~MXgsAH-VVmt9NmbfmP2xYccz6Ai04MU7sxUtag__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043034"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status"><img alt="Research paper thumbnail of γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status" class="work-thumbnail" src="https://attachments.academia-assets.com/116784467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status">γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status</a></div><div class="wp-workCard_item"><span>International journal of molecular sciences</span><span>, Jan 3, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever increasing. Despite decades of research, still, there is a shortage of non-toxic, safe and effective medical countermeasures for radiological and nuclear emergency. To date, the U.S. Food and Drug Administration (U.S. FDA) has approved only two growth factors, Neupogen (granulocyte colony-stimulating factor (G-CSF), filgrastim) and Neulasta (PEGylated G-CSF, pegfilgrastim) for the treatment of hematopoietic acute radiation syndrome (H-ARS) following the Animal Efficacy Rule. Promising radioprotective efficacy results of γ-tocotrienol (GT3; a member of the vitamin E family) in the mouse model encouraged its further evaluation in the nonhuman primate (NHP) model. These studies demonstrated that GT3 significantly aided the recovery of radiation-induced neutropenia and thrombocytopenia compared to the vehicle controls; these results particularly significant after exposure to 5.8 or 6.5 Gray (...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9562f186e218e629fd84fe9819369873" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784467,"asset_id":122043034,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784467/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043034"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043034"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043034; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043034]").text(description); $(".js-view-count[data-work-id=122043034]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043034; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043034']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9562f186e218e629fd84fe9819369873" } } $('.js-work-strip[data-work-id=122043034]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043034,"title":"γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status","internal_url":"https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784467/download_file","bulk_download_file_name":"Tocotrienol_as_a_Promising_Countermeas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784467/pdf-libre.pdf?1720980939=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_as_a_Promising_Countermeas.pdf\u0026Expires=1740391655\u0026Signature=J8ec1VGUrAvmAShgYpi30nt4XlCI2YA1g89iJlIuxOXglvxjO1tqxR9IBpw-lZpIdFgJiEypwENk-ou0IoHAGJglUXsGOjKICdP6YxCsRNGbUFrkAH-i8tq0Y4nTzH2jWn-Oqnln0gGMHZGXbx6ATG6-8GQ-REnCSPhJWa15wEjlscWVJBCp8WwkcE8lksr8sHFNydUcyd1pv2XCV-cAyQEz6b0pzLPQdN83-tNa59LUbOiU4aCWI24RhDnRSh8yZAJdFgzieiWqsFqctzzZOxbDOc9qZu6s1RSKg7BcfXzt0MBBD6TRAs5oUQL1f7R45sdKRN5D5Byou7xuhSOT9A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043033"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway"><img alt="Research paper thumbnail of Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/116784480/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway">Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway</a></div><div class="wp-workCard_item"><span>Cell death & disease</span><span>, Jan 23, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells. Whether Lxn functions as a tumor suppressor in leukemia and what molecular and cellular mechanisms are involved are unknown. In this study, the myeloid leukemogenic FDC-P1 cell line was used as a model system and Lxn was ectopically expressed in these cells. Using the protein pull-down assay and mass spectrometry, ribosomal protein subunit 3 (Rps3) was identified as a novel Lxn binding protein. Ectopic expression of Lxn inhibited FDC-P1 growth in vitro. More surprisingly, Lxn enhanced gamma irradiation-induced DNA damages and induced cell-cycle arrest and massive necrosis, leading to depletion of FDC-P1 cells. Mechanistically, Lxn inhibited the nuclear translocation of Rps3 upon radiation, resulting in abnormal mitotic spindle formation ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78b5aba0171aef445924e10a953ef16a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784480,"asset_id":122043033,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784480/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043033"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043033"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043033; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043033]").text(description); $(".js-view-count[data-work-id=122043033]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043033; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043033']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78b5aba0171aef445924e10a953ef16a" } } $('.js-work-strip[data-work-id=122043033]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043033,"title":"Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway","internal_url":"https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784480,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784480/thumbnails/1.jpg","file_name":"cddis2014443.pdf","download_url":"https://www.academia.edu/attachments/116784480/download_file","bulk_download_file_name":"Latexin_sensitizes_leukemogenic_cells_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784480/cddis2014443-libre.pdf?1720980923=\u0026response-content-disposition=attachment%3B+filename%3DLatexin_sensitizes_leukemogenic_cells_to.pdf\u0026Expires=1740391655\u0026Signature=NguDOHCOivRcC2Y2o4gEh1OqiwyNb4QtEL9nV2MgNv5ge7lKHDOwCgKu~yOCD-MiUB3s4G1CTSDsiHBWdfQKKZo4Yt-ujT-d4IVXJEShsq3g5JOrLI2SgXmXx7Cwx~-jAtWMSGqLVij5OxqfT5TWHepqOEB5DFR8t8K6jxK6ws-~gdpwVTXyb-AAntxNNv2WZnSdvivawZqoYEnBaQD5EcRnvg7x1HND-6j67T~~tHrVFrnGouNAhwDLQPkIKe4xsSWZTQxaGjkKTDHLk2LP1PLO901PhvhOLDEqnbzxgpyYnx8KoLbPRibAX-c8g1Sz5o8IH7yvqoTmZR01JQ8bHA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043032"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy"><img alt="Research paper thumbnail of Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy">Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy</a></div><div class="wp-workCard_item"><span>Radiation Research</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Martin Hauer-Jensen, Konrad K. Richter, Junru Wang, Etsuko Abe, Ching-Ching Sung and James W....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Martin Hauer-Jensen, Konrad K. Richter, Junru Wang, Etsuko Abe, Ching-Ching Sung and James W. Hardin Departments of Surgery, Medicine and Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043032; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043032]").text(description); $(".js-view-count[data-work-id=122043032]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043032; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043032']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043032]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043032,"title":"Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy","internal_url":"https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043031"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity"><img alt="Research paper thumbnail of Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/116852859/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity">Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity</a></div><div class="wp-workCard_item"><span>Nature Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">AUTHOR CONTRIBUTION H. Geiger, designed and performed experiments, wrote the paper S.A. Pawar, co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">AUTHOR CONTRIBUTION H. Geiger, designed and performed experiments, wrote the paper S.A. Pawar, collected, analyzed, and summarized data E.J. Kerschen, performed experiments K. Nattamai, performed experiments, wrote parts of the paper I. Hernandez, performed experiments H.P. Liang, performed experiments J. A. Fernandez, provided reagents and advised on experimental design J.A. Cancelas, performed experiments M.A. Ryan, performed experiments O. Kustikova, advised on experimental design and provided experimental expertise A. Schambach, advised on experimental design and provided reagents Q. Fu, performed in vivo studies J. Wang, performed in vitro studies L.M. Fink, advised on experimental design and participated in writing the manuscript K-U. Petersen, performed PK studies with solulin and advised on experimental details D. Zhou, advised on experimental design and provided experimental expertise J. H. Griffin, provided reagents and advised on experimental design C. Baum, advised on experimental design and provided experimental expertise H. Weiler, designed and performed experiments, wrote the paper M. Hauer-Jensen, designed experiments, wrote the paper</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="26ead6672439f0805e71bba7e7e03ebb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116852859,"asset_id":122043031,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116852859/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043031"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043031"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043031; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043031]").text(description); $(".js-view-count[data-work-id=122043031]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043031; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043031']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "26ead6672439f0805e71bba7e7e03ebb" } } $('.js-work-strip[data-work-id=122043031]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043031,"title":"Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity","internal_url":"https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116852859,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116852859/thumbnails/1.jpg","file_name":"pmc3491776.pdf","download_url":"https://www.academia.edu/attachments/116852859/download_file","bulk_download_file_name":"Pharmacological_targeting_of_the_thrombo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116852859/pmc3491776-libre.pdf?1721227302=\u0026response-content-disposition=attachment%3B+filename%3DPharmacological_targeting_of_the_thrombo.pdf\u0026Expires=1740391655\u0026Signature=V-vODytfPd-RPbp-Dnue2n~DQULOHsSitg3Q7won6KFg5-nt4jYazezBwaw4TAwIU3FaahzpMXXmziiPV73694Uuh78w2JR5oFGeLlrju0w-OddycuOL572uD07Noj2tPfM-6835GKh4GuomBtqnGpxAOIQfX3JSxd~DWZu7xP3DCIQ6PyBRTCqwLf9sk4JNhwX5NgPypTPIzfhqUMrAv4xfu8rftsp-IUEGR4C0X5VTn2Re6uWVWVhLhnv7yzhBv0E5T49S0GLvd8ACvoUXTNK~sF73o1D0gLP4zXAYrpOK5LqfO3IF9wonEnMEZv-7gZXJldGwg5rI5vWgA1bznw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin"><img alt="Research paper thumbnail of Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin" class="work-thumbnail" src="https://attachments.academia-assets.com/116784438/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin">Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin</a></div><div class="wp-workCard_item"><span>Current Drug Targets</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="136a904f4e404d3fd2464eb0e21b7b1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784438,"asset_id":122043030,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784438/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043030]").text(description); $(".js-view-count[data-work-id=122043030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "136a904f4e404d3fd2464eb0e21b7b1a" } } $('.js-work-strip[data-work-id=122043030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043030,"title":"Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin","internal_url":"https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784438,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784438/thumbnails/1.jpg","file_name":"72533.txt","download_url":"https://www.academia.edu/attachments/116784438/download_file","bulk_download_file_name":"Novel_Strategies_to_Ameliorate_Radiation.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784438/72533.txt?1720976984=\u0026response-content-disposition=attachment%3B+filename%3DNovel_Strategies_to_Ameliorate_Radiation.txt\u0026Expires=1740391655\u0026Signature=VJTy4q~5mKgcABSzdeypIJwwrh96k3CnUW2QhWKBL-OJA2q3QaBss8vE0dpM500H1XZX9S-ZbPlzWV2EykBPQTF4TGJDBkO~Wl6O5FJ2vsRcP6hQiNk7k1HvwvR~L~0qL8E9FOAX6m9dzVAgcIBA6x46l97LqvFGha-rz1DxSEVyuX-kao9skGRBFFTaafNm0Z5GigR0zSPmkpL2Cxw-rdOikdG6J7ma9FmhZi3AysNqkNJbif7nGDtdsux-DONKDD4fx7UZRGMlMSZfJ22n-a4FAv7P6WUJR5LwM-tIq4gHgOabiPokBlUok5niGoUbGqLorPu6GXc~EnrVCGS~aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784437,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784437/thumbnails/1.jpg","file_name":"72533.txt","download_url":"https://www.academia.edu/attachments/116784437/download_file","bulk_download_file_name":"Novel_Strategies_to_Ameliorate_Radiation.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784437/72533.txt?1720976984=\u0026response-content-disposition=attachment%3B+filename%3DNovel_Strategies_to_Ameliorate_Radiation.txt\u0026Expires=1740391655\u0026Signature=NzVOk94uUFvGz72c6vHAnJ7PSyknj9VZcl7xTf~lqywDoypHnWmw0FqCXmxmHpBJvlbLaUzn6BgMe5i2PC~qKjBiM8OGVMW078hHJpasLoh~LEx3Liyn4~HdnguBIFuKWoyaeFxToW2TI-wVIUcvq~N0tLeAGPeW8~RMBENmNalKrVYNfZFIxqCKgG0ALgmj~9Y9E1NPTFtJY1n~VAmleBPV3O8RhXgpWshVUOIaLUPz3-zxz5gtW2s~46sSAqqNNie-zqVunRb9FHpp3xEvg8fdVPjSWTiIQMuh-bEUF63B-JVbbfj-eM1PtYxcVKEwrxcordsZz92uzCT4JKQDtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia"><img alt="Research paper thumbnail of Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia">Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia</a></div><div class="wp-workCard_item"><span>Blood Coagulation & Fibrinolysis</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thrombomodulin (TM) plays an important role in anticoagulation by forming a complex with thrombin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thrombomodulin (TM) plays an important role in anticoagulation by forming a complex with thrombin, which subsequently activates protein C. TM is inactivated and downregulated by inflammatory cell mediators. This study examined whether bronchopneumonia is associated with changes in TM immunoreactivity, and whether a decrease in TM is accompanied by evidence of hypercoagulability, i.e. local deposition of fibrin. Double antibody staining for TM and fibrin was performed on lung tissue sections from patients who had died of pneumonia and from patients who had died rapidly, secondary to trauma. Inflammatory changes were assessed histologically and immunohistochemically using antibodies against interleukin-1alpha, tumor necrosis factor-alpha, and myeloperoxidase. Areas with bronchopneumonia exhibited markedly decreased endothelial TM staining of alveolar walls and small vessels. These changes were associated with prominent fibrin immunoreactivity. Some areas exhibited mild to moderate inflammation with little fibrin deposition and variable amounts of TM in adjacent vessels. This study is the first to relate changes of TM immunoreactivity levels to fibrin deposition in a human disease process. These data may have implications for pulmonary pathophysiology in patients with bronchopneumonia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043029]").text(description); $(".js-view-count[data-work-id=122043029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043029,"title":"Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia","internal_url":"https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3339855" id="papers"><div class="js-work-strip profile--work_container" data-work-id="127218268"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism"><img alt="Research paper thumbnail of γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism" class="work-thumbnail" src="https://attachments.academia-assets.com/120984458/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism">γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism</a></div><div class="wp-workCard_item"><span>Radiation Research</span><span>, May 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Analogs of vitamin E (tocols) are under development as radioprophylactic agents because of their ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analogs of vitamin E (tocols) are under development as radioprophylactic agents because of their high efficacy and lack of toxicity. Gamma-tocotrienol (GT3) is of particular interest because, in addition to being an antioxidant, it also inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and accumulates to greater extent in endothelial cells than other tocols. We addressed in vivo whether HMG-CoA reductase inhibition contributes to the radioprotection conferred by GT3. Groups of mice were treated with vehicle, mevalonate (the product of the reaction catalyzed by HMG-CoA reductase), GT3 alone or GT3 in combination with mevalonate. Lethality and standard parameters of injury to the hematopoietic, intestinal and vascular/ endothelial systems were assessed after exposure to total-body irradiation. GT3 improved postirradiation survival and decreased radiation-induced vascular oxidative stress, an effect that was reversible by mevalonate. GT3 also enhanced hematopoietic recovery, reduced intestinal radiation injury, and accelerated the recovery of soluble markers of endothelial function. These parameters were not reversed by mevalonate co-administration. Our data confirm GT3's radioprophylactic properties against hematopoietic injury and, for the first time, demonstrate benefits in terms of protection against gastrointestinal and vascular injury. The radioprotective efficacy of GT3 against vascular injury is related to its properties as an HMG-CoA reductase inhibitor.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ee61e41dd32a856ba65bb0a90a9eb1ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":120984458,"asset_id":127218268,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/120984458/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="127218268"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="127218268"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 127218268; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=127218268]").text(description); $(".js-view-count[data-work-id=127218268]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 127218268; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='127218268']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ee61e41dd32a856ba65bb0a90a9eb1ea" } } $('.js-work-strip[data-work-id=127218268]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":127218268,"title":"γ-Tocotrienol Ameliorates Intestinal Radiation Injury and Reduces Vascular Oxidative Stress after Total-Body Irradiation by an HMG-CoA Reductase-Dependent Mechanism","internal_url":"https://www.academia.edu/127218268/%CE%B3_Tocotrienol_Ameliorates_Intestinal_Radiation_Injury_and_Reduces_Vascular_Oxidative_Stress_after_Total_Body_Irradiation_by_an_HMG_CoA_Reductase_Dependent_Mechanism","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":120984458,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/120984458/thumbnails/1.jpg","file_name":"pmc2713014.pdf","download_url":"https://www.academia.edu/attachments/120984458/download_file","bulk_download_file_name":"Tocotrienol_Ameliorates_Intestinal_Rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/120984458/pmc2713014-libre.pdf?1737675669=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_Ameliorates_Intestinal_Rad.pdf\u0026Expires=1740391655\u0026Signature=ZkCofkufEryRQ0FTdln5p7d5cD40M926Z6HsAHx~C5oJ-a~Vl7stuasmKBbG9A9AbfGgKpjRVIi7ISX7g6RxVb8OpYH32mQt4DHdClYW1dcjtHRDm63RYyUxzbyzzjqeRXEXLnGp-VsWLF0oRnNSbxOKLIcie3zj-UsATnI3uODfxs6Ghmx9H2jnT5P27mwXaHPkH7WE5J0QhcfJEHtdic0AWOK-iWkAGO7EOF3vgDAj-eQMvPcjY-hSY9LRLiDgdM06xPI6OLVCsUVbAL70qibwrstet~keSBooSWb~GF8fbJ8O3dTrbM0WP616hFKgAId7ezhz3dC81iBWDLGbxg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":120984457,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/120984457/thumbnails/1.jpg","file_name":"pmc2713014.pdf","download_url":"https://www.academia.edu/attachments/120984457/download_file","bulk_download_file_name":"Tocotrienol_Ameliorates_Intestinal_Rad.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/120984457/pmc2713014-libre.pdf?1737675674=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_Ameliorates_Intestinal_Rad.pdf\u0026Expires=1740391655\u0026Signature=Klnb~Uqfy30c8rkJEbd-MnTgKhIKRet0r2IQbkvixoeMImR7VYp593MblKM~2yvQb4QQv76KPKl9DjVUE3qal-2R2p0cVQJBCjd-LnqpwvWVN7ZzJgxIbZ7LkmobpoIzlygexRkDmcHeNlruHFF35GCCv5claSiB2RrnSnK6C-jTAN1LFqMNg0EhiWbszTeQh5-hyunE--v9NqtelKALTFv8wE8Zq4oiE1O6f9dh4RuHAN678t0xY37RkdbXOxFTho5EzwJLew2YPyL6vN7Ol~1SOnsG8-1PNphesb8aclH0XDHjHN9JOysn2NJyQxjSZwbo107MmTDVgbV5udsBNQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="124689624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine"><img alt="Research paper thumbnail of Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine" class="work-thumbnail" src="https://attachments.academia-assets.com/118868787/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine">Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine</a></div><div class="wp-workCard_item"><span>Antioxidants & Redox Signaling</span><span>, Mar 20, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The biological effects of ionizing radiation (IR) from environmental, medical, and man-made sourc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The biological effects of ionizing radiation (IR) from environmental, medical, and man-made sources, as well as from space exploration are of broad health concern. During the last 40 years it has become evident that, in addition to short-lived free radical-mediated events initiated within microseconds of exposure and generally thought to dissipate within milliseconds, IR-induced production of reactive oxygen and nitrogen species as well as changes in redox signaling linked to disruption of metabolic processes persist long after radiation exposure. Furthermore, persistent IR-induced increases in the metabolic production of reactive oxygen and nitrogen species appear to significantly contribute to the delayed effects of IR exposure, including induction of adaptive responses at low doses as well as carcinogenesis, fibrosis, inflammation, genomic instability, and acceleration of the onset of degenerative tissue injury processes associated with aging. The ability to identify the specific metabolic mechanisms and dose-response relationships that contribute to adaptive responses as well as persistent IR-induced injury processes holds great promise for identifying novel strategies to mitigate the deleterious effects of IR exposure as well as for gathering mechanistic information critical for risk assessment. This Forum contains original and review articles authored by experts in the field of radiobiology focusing on novel mechanisms involving redox biology and metabolism that significantly contribute to the persistent biological effects seen following IR exposure. Antioxid. Redox Signal. 20, 1407-1409.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="972c5310f57003c4e2451fe68a380119" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118868787,"asset_id":124689624,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118868787/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="124689624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="124689624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124689624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124689624]").text(description); $(".js-view-count[data-work-id=124689624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124689624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='124689624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "972c5310f57003c4e2451fe68a380119" } } $('.js-work-strip[data-work-id=124689624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":124689624,"title":"Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine","internal_url":"https://www.academia.edu/124689624/Ionizing_Radiation_Induced_Responses_Where_Free_Radical_Chemistry_Meets_Redox_Biology_and_Medicine","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":118868787,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118868787/thumbnails/1.jpg","file_name":"pmc3936498.pdf","download_url":"https://www.academia.edu/attachments/118868787/download_file","bulk_download_file_name":"Ionizing_Radiation_Induced_Responses_Whe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118868787/pmc3936498-libre.pdf?1728860500=\u0026response-content-disposition=attachment%3B+filename%3DIonizing_Radiation_Induced_Responses_Whe.pdf\u0026Expires=1740391655\u0026Signature=J8IE42S~v5i0MO-uhmuaGU9BqjTLUVYSwfPO4qtNCwvCcd57W~WyC-52EWbn65xJF-C8zqady16yW~h0PTaxBzLoQy800x~EctK0PVE5Hgp7dPol6vgQKwRacqJuPYATd-PYQ-DkAhjtFOtMJNy5~K2A0AL8c9ivAyBXHbf9vnLyhtOTzL6DYhizWgkU6yGA4UWOD-x~lhTkoGhG81iF2EHBKS-qRPd0Kb6QEacYP-K9icLGDaGc0T2om4ZoulyNf054TBVfSRx3otgaYvhPO4fA9uy6NISb4Pv-OaGD9PVw5P7CVLKqueJMgKg9fXONNn71ntnqP-vxTYlaDJfokA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":118868788,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/118868788/thumbnails/1.jpg","file_name":"pmc3936498.pdf","download_url":"https://www.academia.edu/attachments/118868788/download_file","bulk_download_file_name":"Ionizing_Radiation_Induced_Responses_Whe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/118868788/pmc3936498-libre.pdf?1728860502=\u0026response-content-disposition=attachment%3B+filename%3DIonizing_Radiation_Induced_Responses_Whe.pdf\u0026Expires=1740391655\u0026Signature=HsRwVWCDPwwA1qbjW4~SrwE7ZnVOfSml6bor7S3zA~JRNmxj2u44wDYrFb1WEFoFYtr5NpzoReWPS4E-jCXsdJCGvdeYE0ulYfsqnb19go41EL~cb6r7zUjchwNjIfbczG0D39AdnO5mZx8O~LPrJuE~9updd1kMazlAnZum0Z2xUCOynhNYJzH97Eu5qnbbE6kJKatDwelh3RoWdwF9MZD~9r2AXrDwN~4HaUf4rPA-VmJuC~5pWdhaW1gGpDCML1I~P31GQg5pL7rHg67xApV5tGd--heJP~-X-nbVthFQi3abXVTSw1UQLVFEU5XES3NnZNugvF7kJtgdItDJDQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043046"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells"><img alt="Research paper thumbnail of Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells" class="work-thumbnail" src="https://attachments.academia-assets.com/116784447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells">Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells</a></div><div class="wp-workCard_item"><span>Differentiation</span><span>, Sep 1, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Induced pluripotent stem (iPS) cells are derived from reprogrammed somatic cells and are similar ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Induced pluripotent stem (iPS) cells are derived from reprogrammed somatic cells and are similar to embryonic stem (ES) cells in morphology, gene/protein expression, and pluripotency. In this study, we explored the potential of iPS cells to differentiate into alveolar Type II (ATII)-like epithelial cells. Analysis using quantitative real time polymerase chain reaction and immunofluorescence staining showed that pulmonary surfactant proteins commonly expressed by ATII cells such as surfactant protein A (SPA), surfactant protein B (SPB), and surfactant protein C (SPC) were upregulated in the differentiated cells. Microphilopodia characteristics and lamellar bodies were observed by transmission electron microscopy and lipid deposits were verified by Nile Red and Periodic Acid Schiff staining. C3 complement protein, a specific feature of ATII cells, was present at high levels in culture supernatants demonstrating functionality of these cells in culture. These data show that the differentiated cells generated from iPS cells using a culture method developed previously (Rippon et al., 2006) are ATII-like cells. To further characterize these ATII-like cells, we tested whether they could undergo epithelial to mesenchymal transition (EMT) by exposure to drugs that induce lung fibrosis in mice, such as bleomycin, and the combination of transforming growth factor beta1 (TGF b1) and epidermal growth factor (EGF). When the ATII-like cells were exposed to either bleomycin or a TGF b1-EGF cocktail, they underwent phenotypic changes including acquisition of a mesenchymal/fibroblastic morphology, upregulation of mesenchymal markers (Col1, Vim, a-Sma, and S100A4), and downregulation of surfactant proteins and E-cadherin. We have shown that ATII-like cells can be derived from skin fibroblasts and that they respond to fibrotic stimuli. These cells provide a valuable tool for screening of agents that can potentially ameliorate or prevent diseases involving lung fibrosis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8979fd08f36e0e7813eb617f98cf4ae2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784447,"asset_id":122043046,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043046"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043046; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043046]").text(description); $(".js-view-count[data-work-id=122043046]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043046; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043046']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8979fd08f36e0e7813eb617f98cf4ae2" } } $('.js-work-strip[data-work-id=122043046]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043046,"title":"Epithelial to mesenchymal transition (EMT) induced by bleomycin or TFGb1/EGF in murine induced pluripotent stem cell-derived alveolar Type II-like cells","internal_url":"https://www.academia.edu/122043046/Epithelial_to_mesenchymal_transition_EMT_induced_by_bleomycin_or_TFGb1_EGF_in_murine_induced_pluripotent_stem_cell_derived_alveolar_Type_II_like_cells","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784447/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/116784447/download_file","bulk_download_file_name":"Epithelial_to_mesenchymal_transition_EMT.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784447/viewcontent-libre.pdf?1720980930=\u0026response-content-disposition=attachment%3B+filename%3DEpithelial_to_mesenchymal_transition_EMT.pdf\u0026Expires=1740391655\u0026Signature=RQq54thGUqh3Zn6JeHY4mB8oh57u7o0iCeaU0oYIWIaerPegUlrA~EkDIHWeCeBpzbNsOa9w7aV4AN6MOjMMryTdQIdGeZiivn6QWZa1KcT28V1~-XTgmn~dwdgHLDhO5~l5ZkgNN0mmny~oaA7rl0OVzdAt9S9nJKmjEC9-lrnUHXMKscmNMyDqeVwW7XIJqhdqgUjg7GvjTgyJehBeowWu0EGk3uTpWexzedTmOA0L3UzIYzhp3SSS~VwviTV9uxpi1UxKutuleLUnvhoDzJZLaR54ajt1ompt-YDYzL7gwgB6zMep5N2JMYDM9nVuoEYwXNOqCn42xAoi9D05QQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784448,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784448/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/116784448/download_file","bulk_download_file_name":"Epithelial_to_mesenchymal_transition_EMT.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784448/viewcontent-libre.pdf?1720980934=\u0026response-content-disposition=attachment%3B+filename%3DEpithelial_to_mesenchymal_transition_EMT.pdf\u0026Expires=1740391655\u0026Signature=cNDWO3teZWL5JN9vbo83GpBVf5KrtkBNkR5xOvRfpaHQ43h7-bWeJeo~7GymClynYloEThuYq7cxsjyv~3oHX0lxGKlGKAAelFniZ1xJ9LWbX7SJ1I6LRi1OONMyXkRYJmNJuhIf9Z6sCx4y6IAh-HAThtR9l0njCwnb5GvCWgP2N7C5U6oj~PMHNXvwFJf1i~wVBIqPUHqUAvGTbYUuhdMr~4df3CtHabMqbce5vJ~z4cAdUYH90M1iNV4XYSW3oJdLxmSaPp6w-svZ6Zsjf0nPT-Q2EZ-epYfioMkxBY-jz19haRtu5AHN7BNETipVad47W9xyWHyoTFiBHg6Kbw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model"><img alt="Research paper thumbnail of Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model" class="work-thumbnail" src="https://attachments.academia-assets.com/116784446/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model">Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radiation exposure causes acute damage to hematopoietic and immune cells. To date, there are no radioprotectors available to mitigate hematopoietic injury after radiation exposure. Gamma-tocotrienol (GT3) has demonstrated promising radioprotective efficacy in the mouse and nonhuman primate (NHP) models. We determined GT3-mediated hematopoietic recovery in total-body irradiated (TBI) NHPs. Sixteen rhesus macaques divided into two groups received either vehicle or GT3, 24 h prior to TBI. Four animals in each treatment group were exposed to either 4 or 5.8 Gy TBI. Flow cytometry was used to immunophenotype the bone marrow (BM) lymphoid cell populations, while clonogenic ability of hematopoietic stem cells (HSCs) was assessed by colony forming unit (CFU) assays on day 8 prior to irradiation and days 2, 7, 14, and 30 post-irradiation. Both radiation doses showed significant changes in the frequencies of B and T-cell subsets, including the self-renewable capacity of HSCs. Importantly, GT3...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a44813704ff3bd4cdff7c90a660d0884" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784446,"asset_id":122043045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784446/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043045]").text(description); $(".js-view-count[data-work-id=122043045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a44813704ff3bd4cdff7c90a660d0884" } } $('.js-work-strip[data-work-id=122043045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043045,"title":"Gamma-Tocotrienol Modulates Total-Body Irradiation-Induced Hematopoietic Injury in a Nonhuman Primate Model","internal_url":"https://www.academia.edu/122043045/Gamma_Tocotrienol_Modulates_Total_Body_Irradiation_Induced_Hematopoietic_Injury_in_a_Nonhuman_Primate_Model","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784446,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784446/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784446/download_file","bulk_download_file_name":"Gamma_Tocotrienol_Modulates_Total_Body_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784446/pdf-libre.pdf?1720980947=\u0026response-content-disposition=attachment%3B+filename%3DGamma_Tocotrienol_Modulates_Total_Body_I.pdf\u0026Expires=1740391655\u0026Signature=DCSeFzRt3fI9Im~MbzIfokbnguxtcf0e0xrCa1Hc6F2Ednj3uW4IiPN3yUQGwbDiUNhdfMr2WGk1PyTqTO75Htiq3PJOzKDfztozpvvuv3JEb1QlsrgGjRgWALvq6mLJpQN~79Dp5fXTqET~YGUXcXbH5tTZvCXOCbvORzlyvCd78h6w1VXM9Haeg7iWFbfm8jXTqbEAAUl8ripoaQ9mmjhy-C4nywh6TrJDHyrA7ne6anSiQiZz8kAPLxgBNQWV4jYuqI78aXy80aUKzTzsAhZBKWReXPktbZxm6dB5FNJWWQ1x0k1w-QrmFCrF9~QbgL8eK7-94D8BQTsgvgnnoA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043044"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model"><img alt="Research paper thumbnail of Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model" class="work-thumbnail" src="https://attachments.academia-assets.com/116784444/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model">Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model</a></div><div class="wp-workCard_item"><span>Antioxidants</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Exposure to high doses of radiation, accidental or therapeutic, often results in gastrointestinal...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Exposure to high doses of radiation, accidental or therapeutic, often results in gastrointestinal (GI) injury. To date, there are no therapies available to mitigate GI injury after radiation exposure. Gamma-tocotrienol (GT3) is a promising radioprotector under investigation in nonhuman primates (NHP). We have shown that GT3 has radioprotective function in intestinal epithelial and crypt cells in NHPs exposed to 12 Gy total-body irradiation (TBI). Here, we determined GT3 potential in accelerating the GI recovery in partial-body irradiated (PBI) NHPs using X-rays, sparing 5% bone marrow. Sixteen rhesus macaques were treated with either vehicle or GT3 24 h prior to 12 Gy PBI. Structural injuries and crypt survival were examined in proximal jejunum on days 4 and 7. Plasma citrulline was assessed using liquid chromatography–tandem mass spectrometry (LC-MS/MS). Crypt cell proliferation and apoptotic cell death were evaluated using Ki-67 and TUNEL staining. PBI significantly decreased muco...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c95bcc75a09d1302f805268ad5bc95ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784444,"asset_id":122043044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784444/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043044]").text(description); $(".js-view-count[data-work-id=122043044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c95bcc75a09d1302f805268ad5bc95ec" } } $('.js-work-strip[data-work-id=122043044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043044,"title":"Effects of Gamma-Tocotrienol on Partial-Body Irradiation-Induced Intestinal Injury in a Nonhuman Primate Model","internal_url":"https://www.academia.edu/122043044/Effects_of_Gamma_Tocotrienol_on_Partial_Body_Irradiation_Induced_Intestinal_Injury_in_a_Nonhuman_Primate_Model","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784444,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784444/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784444/download_file","bulk_download_file_name":"Effects_of_Gamma_Tocotrienol_on_Partial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784444/pdf-libre.pdf?1720980942=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Gamma_Tocotrienol_on_Partial.pdf\u0026Expires=1740391655\u0026Signature=RQ96U-0oEBAzJ1fbmS-wHc-sKPb~F7EM39U~8jTNSW4begrSRYmfqkCR247o3tO5SC5PRWtJTy-1WHD4guZKoH7uT2N5zIkBtRPNwuLC6BkBb~yO7NyBMX45T7RKg3j6tyF1xc~AFqoeCCtP-NjwmR7xkox2k6icnMrG4C~8LF5nH7ZhdPMkTKm1YsSge9B5kuMNFXb2GCg4N9PT6vg-o02ioNs~uxdb5~tQffbh3m~GVUo7JAXdrhJOMWydK2XQJyigbubas8mV6C2rHsTlmVyIvdbxUDMkTyx311IFw3fF3axuFGJEnGLeLKME5ph~Rbr-JnVmfyTra6-oqVvRpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784445,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784445/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784445/download_file","bulk_download_file_name":"Effects_of_Gamma_Tocotrienol_on_Partial.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784445/pdf-libre.pdf?1720980943=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Gamma_Tocotrienol_on_Partial.pdf\u0026Expires=1740391655\u0026Signature=XCa3bxBq6pnliKzTTL2ZI4faeVSZwL-JUAOnUP8lXVH0jvjPXpRyZeWE12Q15LXIfQsw0zxxQlavw-Y8cJKZnLJP6qWSH8Elm3VuP08DT~exKTAYdoK0d~aO2K~aAteHLY5rbJR2xfCxjlYAexaLNdSSTl4PcHt5UwCn5mJsgvhyDYLsD7AowZk2AVcw9DtuJUnUNvE8DECDjiPSKnpp0JK3iwLodZx0dfFNlfnS9bAozNaxsS6Yw2uIpYBLil8fDp0Q5TIhkZWAH~p8s3h43DIwsQZ6jnYu7GjDfheXDSxwR~kKRr-5VMG4AYMAHE1aBRmg6MDUeFj1z9aGNsSAPA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043043"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure"><img alt="Research paper thumbnail of Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure" class="work-thumbnail" src="https://attachments.academia-assets.com/116784470/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure">Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure</a></div><div class="wp-workCard_item"><span>Metabolites</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways involved in radiation-induced GI injury, this study assessed dose- and time-dependent changes in plasma metabolites in a nonhuman primate model of whole abdominal irradiation. Male and female adult Rhesus monkeys were exposed to 6 MV photons to the abdomen at doses ranging between 8 and 14 Gy. At time points from 1 to 60 days after irradiation, plasma samples were collected and subjected to untargeted metabolomics. With the limited sample size of females, different discovery times after irradiation between males and females were observed in metabolomics pattern. Detailed analyses are restricted to only males for the discovery power. Radiation caused an increase in fatty acid oxidation and circulating levels of corticosteroids which may be an indication of physiological stress, and amino acids, indicative of a cellular repair respo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a31a31e06176d9d9ab6892492ffbc5e1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784470,"asset_id":122043043,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784470/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043043"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043043"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043043; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043043]").text(description); $(".js-view-count[data-work-id=122043043]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043043; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043043']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a31a31e06176d9d9ab6892492ffbc5e1" } } $('.js-work-strip[data-work-id=122043043]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043043,"title":"Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure","internal_url":"https://www.academia.edu/122043043/Plasma_Metabolomics_in_a_Nonhuman_Primate_Model_of_Abdominal_Radiation_Exposure","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784470,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784470/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784470/download_file","bulk_download_file_name":"Plasma_Metabolomics_in_a_Nonhuman_Primat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784470/pdf-libre.pdf?1720980929=\u0026response-content-disposition=attachment%3B+filename%3DPlasma_Metabolomics_in_a_Nonhuman_Primat.pdf\u0026Expires=1740391655\u0026Signature=TYhRLjM7x1cEBw-L9r9KLBqnnBfs9nFIJAjaS7xP7VSUC7CaUvEs8och7GY1J6R0u35vLKkVXRAcBXLpH8k~FJ59vMEwk8697BLK7~snSuqSP9hdKvblofzx2gxZNq5XPY4FcPMR5Qv6D6xV42zUcWTHIb6owZtKo8zpGOsZp-FxcjshN8KpqrZAtRO9YzIBOV9R50~8nXp~GBAcjdFCXImWIHvwdtMga7nKeAX20avyG0HfwOGsEHZGlNVnlLQkUN07DVN4HabO6JZtF3~yp7Gvtlkv8JfmRM7JFMf9~PwSiuJvLaWrZYGQMAoIRwCzzapAdGq4XZg~Q7Rcb-mGaA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043042"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells"><img alt="Research paper thumbnail of Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/116784443/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells">Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both cell and animal studies have shown that complete or partial deficiency of methionine inhibit...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Both cell and animal studies have shown that complete or partial deficiency of methionine inhibits tumor growth. Consequently, the potential implementation of this nutritional intervention has recently been of great interest for the treatment of cancer patients. Unfortunately, diet alteration can also affect healthy immune cells such as monocytes/macrophages and their precursor cells in bone marrow. As around half of cancer patients are treated with radiotherapy, the potential deleterious effect of dietary methionine deficiency on immune cells prior to and/or following irradiation needs to be evaluated. Therefore, we examined whether modulation of methionine content alters genetic stability in the murine RAW 264.7 monocyte/macrophage cell line in vitro by chromosomal analysis after 1-month culture in a methionine-deficient or supplemented medium. We also analyzed chromosomal aberrations in the bone marrow cells of CBA/J mice fed with methionine-deficient or supplemented diet for 2 m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f24f0334c31fed4765e436dafb11a89" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784443,"asset_id":122043042,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784443/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043042"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043042"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043042; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043042]").text(description); $(".js-view-count[data-work-id=122043042]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043042; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043042']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f24f0334c31fed4765e436dafb11a89" } } $('.js-work-strip[data-work-id=122043042]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043042,"title":"Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells","internal_url":"https://www.academia.edu/122043042/Dietary_Methionine_Deficiency_Enhances_Genetic_Instability_in_Murine_Immune_Cells","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784443,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784443/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784443/download_file","bulk_download_file_name":"Dietary_Methionine_Deficiency_Enhances_G.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784443/pdf-libre.pdf?1720980938=\u0026response-content-disposition=attachment%3B+filename%3DDietary_Methionine_Deficiency_Enhances_G.pdf\u0026Expires=1740391655\u0026Signature=OpCuOri9N7JqqMiTWaaAuYz1-ck~Uk3Vwlt1NDZZi7hSBwyOUxvqZrvBXPu1hnt~vzFHOe1w2Lh1K~hf1Vike2fdhy3KROl3mvpG~Fw-4cq6ILitjbEJD8KlBFnXDJ1TMlS6tw5H7ubHnWst1VJ7qTu0iYt02lV4xUcUKTBCAoSkUIJGW31hscus-qI4DytfRsk9hYfLvweflqXG2H2LYIbZ29K-SkLkd6KzoY8moplYH8CmqHF1m9Nj0GMDYK7bCRwMf5F~G9F2Q55ruFssX3Q0YBTxJJIZ3BW412i0g2-FWGUxPTQmqknhUk0X3D5eIuX4GRttc1RNGoOLfrKPvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043041"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome"><img alt="Research paper thumbnail of Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/116784471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome">Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Gastrointestinal and Liver Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Methionine is an essential amino acid needed for a variety of processes in living organisms. Ioni...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Methionine is an essential amino acid needed for a variety of processes in living organisms. Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA methylation and decreased synthesis of glutathione. In this study, we aimed to investigate the effects of methionine dietary supplementation in CBA/CaJ mice after exposure to doses ranging from 3 to 8.5 Gy of 137Cs of total body irradiation. We report that mice fed a methionine-supplemented diet (MSD; 19.5 vs. 6.5 mg/kg in a methionine-adequate diet, MAD) developed acute radiation toxicity at doses as low as 3 Gy. Partial body irradiation performed with hindlimb shielding resulted in a 50% mortality rate in MSD-fed mice exposed to 8.5 Gy, suggesting prevalence of radiation-induced gastrointestinal syndrome in the development of acute radiation toxicity. Analysis of the intestinal microbiome demonstrated shifts in the gut ecology, observed along with the development of leaky gut syndrome and bacterial tr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4dd6cabda8c0243d85bf0318193df3a3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784471,"asset_id":122043041,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043041"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043041"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043041; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043041]").text(description); $(".js-view-count[data-work-id=122043041]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043041; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043041']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4dd6cabda8c0243d85bf0318193df3a3" } } $('.js-work-strip[data-work-id=122043041]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043041,"title":"Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome","internal_url":"https://www.academia.edu/122043041/Methionine_dietary_supplementation_potentiates_ionizing_radiation_induced_gastrointestinal_syndrome","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784471/thumbnails/1.jpg","file_name":"ajpgi.00351.pdf","download_url":"https://www.academia.edu/attachments/116784471/download_file","bulk_download_file_name":"Methionine_dietary_supplementation_poten.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784471/ajpgi.00351-libre.pdf?1720980933=\u0026response-content-disposition=attachment%3B+filename%3DMethionine_dietary_supplementation_poten.pdf\u0026Expires=1740391655\u0026Signature=QLz~ZIcqS2LuM8ZE9WsiFLtNT4IDmyjjO98spT2ymXSHOjrrUCa~toMR9xQcgWlaackfKvXX5N2Y2UqXoxDLpyC19xGqUh5XzWjv8pf8nRVCMgQkCrAUVRO7Q6iqsop2dXbc9r6~Gl8ma6ha1hGLhd0l8RMaPRduinH3nffoBZKEfRSyZxVb7YDQ5Ni2HPo48bwela9v~q6agzC8d2UZQeNjzb3lV7w8JPtnbaePbYdo4R9lBzjsXVWlOdUkJCzvwiKpMbgT~d4~7OzREFk2MZY84hb1PqfwOeKGzcoKKfX~YEOl0RBlj5PWNWONtWKRe4bwOixYa5fw0~0xRIg4NQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043040"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress"><img alt="Research paper thumbnail of C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress" class="work-thumbnail" src="https://attachments.academia-assets.com/116784442/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress">C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress</a></div><div class="wp-workCard_item"><span>Scientific Reports</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ionizing radiation (IR)-induced intestinal damage is characterized by a loss of intestinal crypt cells, intestinal barrier disruption and translocation of intestinal microflora resulting in sepsis-mediated lethality. We have shown that mice lacking C/EBPδ display IR-induced intestinal and hematopoietic injury and lethality. The purpose of this study was to investigate whether increased IR-induced inflammatory, oxidative and nitrosative stress promote intestinal injury and sepsis-mediated lethality in Cebpd−/− mice. We found that irradiated Cebpd−/− mice show decreased villous height, crypt depth, crypt to villi ratio and expression of the proliferation marker, proliferating cell nuclear antigen, indicative of intestinal injury. Cebpd−/− mice show increased expression of the pro-inflammatory cytokines (Il-6, Tnf-α) and chemokines (Cxcl1, Mcp-1, Mif-1α) and Nos2 in the intestinal tissues compared to Cebpd+/+ mice after exposure to TBI. Cebpd−/− mice show decreased GSH/GSSG ratio, incr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d7a7e6cce5d44ac4cd66707008d7137d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784442,"asset_id":122043040,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784442/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043040"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043040"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043040; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043040]").text(description); $(".js-view-count[data-work-id=122043040]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043040; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043040']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d7a7e6cce5d44ac4cd66707008d7137d" } } $('.js-work-strip[data-work-id=122043040]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043040,"title":"C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress","internal_url":"https://www.academia.edu/122043040/C_EBP%CE%B4_protects_from_radiation_induced_intestinal_injury_and_sepsis_by_suppression_of_inflammatory_and_nitrosative_stress","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784442,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784442/thumbnails/1.jpg","file_name":"s41598-019-49437-x.pdf","download_url":"https://www.academia.edu/attachments/116784442/download_file","bulk_download_file_name":"C_EBP_protects_from_radiation_induced_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784442/s41598-019-49437-x-libre.pdf?1720980943=\u0026response-content-disposition=attachment%3B+filename%3DC_EBP_protects_from_radiation_induced_i.pdf\u0026Expires=1740391655\u0026Signature=RPQ2zmcf1Va~Ix1VYJhXnpYsSAHztTtL-7G0y2kTVhzLz~H85UzOBFEJn0Zv~M5JPQTCBDV8rxb2fM21aSWpA6dOOcZz77cYIyXWdJrEwcVfjOi8143zvrOBzI8YCmfOhDoPO~Kl0m4gtF7YCXf6qrzc5DiIwVJrfnua7m02Y6hVvjRb81VFuoVcYZ-y2tE4Qhn20njnxpsP89qgNYZAxzng65RVP-pXV6y8ev1H8c6ZxeYJrUTVQ1kk~2lfIA0hBDTw4tTmBalEIxzmDum8MCMzQBuBbxLtesuxPlDrMiHTpMXzWEYNlUS0EY8zc~1bEEQsKmW3-ufwWo9Y1gMw6Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043039"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation"><img alt="Research paper thumbnail of Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation" class="work-thumbnail" src="https://attachments.academia-assets.com/116784439/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation">Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation</a></div><div class="wp-workCard_item"><span>Scientific Reports</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The human kidney embryonic 293 cell line (293 cells) is extensively used in biomedical and pharma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The human kidney embryonic 293 cell line (293 cells) is extensively used in biomedical and pharmaceutical research. These cells exhibit a number of numerical and structural chromosomal anomalies. However, the breakpoints responsible for these structural chromosomal rearrangements have not been comprehensively characterized. In addition, it is not known whether chromosomes with structural rearrangement are more sensitive to external toxic agents, such as ionizing radiation. We used G-banding, spectral karyotyping (SKY), and locus- and region-specific fluorescence in situ hybridization (FISH) probes designed in our lab or obtained from commercial vendor to address this gap. Our G-banding analysis revealed that the chromosome number varies from 66 to 71, with multiple rearrangements and partial additions and deletions. SKY analysis confirmed 3 consistent rearrangements, two simple and one complex in nature. Multicolor FISH analysis identified an array of breakpoints responsible for loc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d62f967dc0f3a6efb3291e4872e14d2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784439,"asset_id":122043039,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784439/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043039"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043039"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043039; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043039]").text(description); $(".js-view-count[data-work-id=122043039]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043039; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043039']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d62f967dc0f3a6efb3291e4872e14d2a" } } $('.js-work-strip[data-work-id=122043039]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043039,"title":"Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation","internal_url":"https://www.academia.edu/122043039/Identification_of_novel_breakpoints_for_locus_and_region_specific_translocations_in_293_cells_by_molecular_cytogenetics_before_and_after_irradiation","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784439,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784439/thumbnails/1.jpg","file_name":"s41598-019-47002-0.pdf","download_url":"https://www.academia.edu/attachments/116784439/download_file","bulk_download_file_name":"Identification_of_novel_breakpoints_for.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784439/s41598-019-47002-0-libre.pdf?1720980941=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_novel_breakpoints_for.pdf\u0026Expires=1740391655\u0026Signature=Tq0StG~xElg6kGhyu0egaC893YwVDG4JQE26gYJsdB8EZZ-F2nbELPQMs2dHvGHDvzPfDgZa7ViFZtrlzKev-l2iCPzXHUnzUs-REUfuGxU~pS68MtdQ5c3Ps2ttdzMP2fvfuC308h1wHSEwHZUztmfMrNDF6dMK~zr6bor7u1FgsR4li9utbUOXj5RXnxiBnGx5u3TOWQvzQWfb9Pvzi9RoojcqT-gA6yLgQ5I45bIOcIANAI4hMzhBe~8uAxCSrmAfXxC44graDAEeA09vM3bke-D~shgHhKOfcnyXCYVHeLMouTeb0YFGjkKEDh1TG0TkrD6KLYqqrHcrjspUFw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784440,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784440/thumbnails/1.jpg","file_name":"s41598-019-47002-0.pdf","download_url":"https://www.academia.edu/attachments/116784440/download_file","bulk_download_file_name":"Identification_of_novel_breakpoints_for.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784440/s41598-019-47002-0-libre.pdf?1720980940=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_novel_breakpoints_for.pdf\u0026Expires=1740391655\u0026Signature=RR3nd1JpLZifoxpAM21ojIkZd5KlzXobzqRWMHt8qORsvblF4VifQPy7YD6h3EyFxNOeD9MrAEUdb7saEYvxV2~IxW~R7IWCPAvqNxDQal8rVj85y7vNhmQG0rj0QUeErTezE~ayP0LigFt7W8j6rR9S9xHsJXKoNj08JvQborKa57kg8ApStCbFQfVYN0biJOuuv73-xHp2pJOmQkGsKsYvfpNPWjOe7ahMm3YL1NAOioizhJLZ3HOSfYtA0rqWAk6Cv4hVUsfoq0RHm10RQYTRFNSZYVhU-Q6T6w0Kg3uEp3c494IrL4ezsi96Q246L-sRg2tVsozAQ1bLBtj1cA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043038"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery"><img alt="Research paper thumbnail of Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery" class="work-thumbnail" src="https://attachments.academia-assets.com/116784441/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery">Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery</a></div><div class="wp-workCard_item"><span>Antioxidants</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Natural antioxidant gamma-tocotrienol (GT3), a vitamin E family member, provides intestinal radia...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Natural antioxidant gamma-tocotrienol (GT3), a vitamin E family member, provides intestinal radiation protection. We seek to understand whether this protection is mediated via mucosal epithelial stem cells or sub-mucosal mesenchymal immune cells. Vehicle- or GT3-treated male CD2F1 mice were exposed to total body irradiation (TBI). Cell death was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Villus height and crypt depth were measured with computer-assisted software in tissue sections. Functional activity was determined with an intestinal permeability assay. Immune cell recovery was measured with immunohistochemistry and Western blot, and the regeneration of intestinal crypts was assessed with ex vivo organoid culture. A single dose of GT3 (200 mg/kg body weight (bwt)) administered 24 h before TBI suppressed cell death, prevented a decrease in villus height, increased crypt depth, attenuated intestinal permeability, and upregulated occludin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7711dd7ceb7f7a6a9a4bee6df671e945" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784441,"asset_id":122043038,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784441/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043038"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043038"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043038; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043038]").text(description); $(".js-view-count[data-work-id=122043038]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043038; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043038']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7711dd7ceb7f7a6a9a4bee6df671e945" } } $('.js-work-strip[data-work-id=122043038]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043038,"title":"Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery","internal_url":"https://www.academia.edu/122043038/Gamma_Tocotrienol_Protects_the_Intestine_from_Radiation_Potentially_by_Accelerating_Mesenchymal_Immune_Cell_Recovery","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784441,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784441/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784441/download_file","bulk_download_file_name":"Gamma_Tocotrienol_Protects_the_Intestine.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784441/pdf-libre.pdf?1720980944=\u0026response-content-disposition=attachment%3B+filename%3DGamma_Tocotrienol_Protects_the_Intestine.pdf\u0026Expires=1740391655\u0026Signature=eg5vjcQkiiBLCDmdCPWpEw4qbDdHrgt8R84cinj6luupLZBpvKwArXnADUsW9otHoAVzLbVOgCGpVyJulYnTGmZ5wRTUJKMzUxIBtIGhkBnCEyEGgkkZk4ZeQjy-kKW5aTuO~TLMuT8KZSRBQXQDATmCcUvTYvRhTrcPXQ7GzJn70sGD-8DpDCePVpghjTDk31vXc3cRJ-axreONy8p623ZCL4Qq-HunUfV~lj6gWnLIcPyLguWqByj0dSd5JBHro0Urrg9XGxYwWO64zxHWiSGTUcu4dZ~MhYP8wOvmBz6StscT~ke6bYVUFXL8AIa6rt-9USV8VUvrkmvGUf0T1Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043037"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity"><img alt="Research paper thumbnail of NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/116784468/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity">NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity</a></div><div class="wp-workCard_item"><span>International Journal of Radiation Biology</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose.-Growing rates of metabolic syndrome and associated obesity warrant the development of ap...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose.-Growing rates of metabolic syndrome and associated obesity warrant the development of appropriate animal models for better understanding of how those conditions may affect sensitivity to IR exposure. Materials and Methods.-We subjected male NZO/HlLtJ mice, a strain prone to spontaneous obesity and diabetes, to 0, 5.5, 6.37, 7.4 or 8.5 Gy (137 Cs) of total body irradiation (TBI). Mice were monitored for 30 days, after which proximal jejunum and colon tissues were collected for further histological and molecular analysis. Results.-Obese NZO/HlLtJ male mice are characterized by their lower sensitivity to IR at doses of 6.37Gy and under, compared to other strains. Further escalation of the dose, however, results in a steep survival curve, reaching LD 100/30 values at a dose of 8.5Gy. Alterations in the expression of various tight junction-related proteins coupled with activation of inflammatory responses and cell death were the main contributors to the gastrointestinal syndrome. Conclusions.-We demonstrate that metabolic syndrome with exhibited hyperglycemia but without alterations to the microvasculature is not a prerequisite of the increased sensitivity to TBI at high doses. Our studies indicate the potential of NZO/HlLtJ mice for the studies on the role of metabolic syndrome in acute radiation toxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d2485364659744520937a1f0cfcfbbc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784468,"asset_id":122043037,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784468/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043037"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043037"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043037; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043037]").text(description); $(".js-view-count[data-work-id=122043037]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043037; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043037']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d2485364659744520937a1f0cfcfbbc" } } $('.js-work-strip[data-work-id=122043037]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043037,"title":"NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity","internal_url":"https://www.academia.edu/122043037/NZO_HlLtJ_as_a_novel_model_for_the_studies_on_the_role_of_metabolic_syndrome_in_acute_radiation_toxicity","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784468,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784468/thumbnails/1.jpg","file_name":"pmc6581619.pdf","download_url":"https://www.academia.edu/attachments/116784468/download_file","bulk_download_file_name":"NZO_HlLtJ_as_a_novel_model_for_the_studi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784468/pmc6581619-libre.pdf?1720980928=\u0026response-content-disposition=attachment%3B+filename%3DNZO_HlLtJ_as_a_novel_model_for_the_studi.pdf\u0026Expires=1740391655\u0026Signature=Z3WLvAYTmmaEj0z7iXphSSnvVpMubDuJNQDcF1LJnj1JTV9pmGiMWiMohmoKUdhTaop-cB9D~86C0abUExvCcDbb~qWZaLr-K7QiDRIaBBNhdM3GzBdLvggI0SyZ02QAkjs--ln8mO3zSlH4uL57WCBy~yconWL~KwxrbLWM21~6~JD2NDQE2C~jkHTGG7mGveWk2pUcvz-kiiYF6jyzGzzGN4m2idC62gaR73TqVlXyOrh7i2XClef9jBsbkY1JV0~jbOn2eaXm00fqeGtYEZevkAL~4~DLqdITAO51mAD4JFoA5h6I9umHf5yb36YpCbplSa6v4MtaJuDQD64UVA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043036"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine"><img alt="Research paper thumbnail of Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine">Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine</a></div><div class="wp-workCard_item"><span>Thrombosis and Haemostasis</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">SummaryEndothelial dysfunction and increased platelet aggregation may be involved in the pathogen...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">SummaryEndothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy).Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-β1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR.Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased TGF-β1 expression. Clopidogrel reduced ADP-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043036"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043036"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043036; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043036]").text(description); $(".js-view-count[data-work-id=122043036]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043036; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043036']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043036]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043036,"title":"Short-Term Inhibition of ADP-Induced Platelet Aggregation by Clopidogrel Ameliorates Radiation-Induced Toxicity in Rat Small Intestine","internal_url":"https://www.academia.edu/122043036/Short_Term_Inhibition_of_ADP_Induced_Platelet_Aggregation_by_Clopidogrel_Ameliorates_Radiation_Induced_Toxicity_in_Rat_Small_Intestine","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043035"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation"><img alt="Research paper thumbnail of Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation" class="work-thumbnail" src="https://attachments.academia-assets.com/116784469/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation">Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation</a></div><div class="wp-workCard_item"><span>International journal of molecular sciences</span><span>, Jan 4, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements in mammalian genomes. LINE-1s are well-accepted as driving forces of evolution and critical regulators of the expression of genetic information. Alterations in LINE-1 DNA methylation may lead to its aberrant activity and are reported in virtually all human cancers and in experimental carcinogenesis. In this study, we investigated the endogenous DNA methylation status of the 5&#39; untranslated region (UTR) of LINE-1 elements in the bone marrow hematopoietic stem cells (HSCs), hematopoietic progenitor cells (HPCs), and mononuclear cells (MNCs) in radioresistant C57BL/6J and radiosensitive CBA/J mice and in response to ionizing radiation (IR). We demonstrated that basal levels of DNA methylation within the 5&#39;-UTRs of LINE-1 elements did not differ significantly between the two mouse strains and were negatively correlated with the evolutionary age of LINE-1 elements. Meanwhile, the expre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ef083fb0e6cae081553ce2353a3fed99" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784469,"asset_id":122043035,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784469/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043035"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043035"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043035; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043035]").text(description); $(".js-view-count[data-work-id=122043035]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043035; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043035']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ef083fb0e6cae081553ce2353a3fed99" } } $('.js-work-strip[data-work-id=122043035]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043035,"title":"Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation","internal_url":"https://www.academia.edu/122043035/Inter_Strain_Differences_in_LINE_1_DNA_Methylation_in_the_Mouse_Hematopoietic_System_in_Response_to_Exposure_to_Ionizing_Radiation","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784469/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784469/download_file","bulk_download_file_name":"Inter_Strain_Differences_in_LINE_1_DNA_M.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784469/pdf-libre.pdf?1720980930=\u0026response-content-disposition=attachment%3B+filename%3DInter_Strain_Differences_in_LINE_1_DNA_M.pdf\u0026Expires=1740391655\u0026Signature=VWIymDYpZHn3megBU3cFtu4pQsTDwGnidK38tntHiqpy9rqM6nrzZXdQGJZtztqlz43xgeOiDovR8rbs9NGtq8yUclGp-dPUNSx1g1belaOn3RqigFrPrGTELbpOIjTElStem2tZqjPWriy1YfJkVTg~kGKoBetqvNwpMQuBIuF7-XUGubAj-CqO6Sg9jluZ1iErqE42dnc5PhyZyH6sVp6Fu8JWVPOWmcZzvAtmosN7RTGPLRAWRS3G2h0eAdXJptpf~BKM9HZacFXu73fWguNWB0~09EeTwQY-SfvE6Q0IH7m~MXgsAH-VVmt9NmbfmP2xYccz6Ai04MU7sxUtag__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043034"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status"><img alt="Research paper thumbnail of γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status" class="work-thumbnail" src="https://attachments.academia-assets.com/116784467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status">γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status</a></div><div class="wp-workCard_item"><span>International journal of molecular sciences</span><span>, Jan 3, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The hazard of ionizing radiation exposure due to nuclear accidents or terrorist attacks is ever increasing. Despite decades of research, still, there is a shortage of non-toxic, safe and effective medical countermeasures for radiological and nuclear emergency. To date, the U.S. Food and Drug Administration (U.S. FDA) has approved only two growth factors, Neupogen (granulocyte colony-stimulating factor (G-CSF), filgrastim) and Neulasta (PEGylated G-CSF, pegfilgrastim) for the treatment of hematopoietic acute radiation syndrome (H-ARS) following the Animal Efficacy Rule. Promising radioprotective efficacy results of γ-tocotrienol (GT3; a member of the vitamin E family) in the mouse model encouraged its further evaluation in the nonhuman primate (NHP) model. These studies demonstrated that GT3 significantly aided the recovery of radiation-induced neutropenia and thrombocytopenia compared to the vehicle controls; these results particularly significant after exposure to 5.8 or 6.5 Gray (...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9562f186e218e629fd84fe9819369873" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784467,"asset_id":122043034,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784467/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043034"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043034"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043034; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043034]").text(description); $(".js-view-count[data-work-id=122043034]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043034; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043034']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9562f186e218e629fd84fe9819369873" } } $('.js-work-strip[data-work-id=122043034]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043034,"title":"γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status","internal_url":"https://www.academia.edu/122043034/%CE%B3_Tocotrienol_as_a_Promising_Countermeasure_for_Acute_Radiation_Syndrome_Current_Status","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784467/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116784467/download_file","bulk_download_file_name":"Tocotrienol_as_a_Promising_Countermeas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784467/pdf-libre.pdf?1720980939=\u0026response-content-disposition=attachment%3B+filename%3DTocotrienol_as_a_Promising_Countermeas.pdf\u0026Expires=1740391655\u0026Signature=J8ec1VGUrAvmAShgYpi30nt4XlCI2YA1g89iJlIuxOXglvxjO1tqxR9IBpw-lZpIdFgJiEypwENk-ou0IoHAGJglUXsGOjKICdP6YxCsRNGbUFrkAH-i8tq0Y4nTzH2jWn-Oqnln0gGMHZGXbx6ATG6-8GQ-REnCSPhJWa15wEjlscWVJBCp8WwkcE8lksr8sHFNydUcyd1pv2XCV-cAyQEz6b0pzLPQdN83-tNa59LUbOiU4aCWI24RhDnRSh8yZAJdFgzieiWqsFqctzzZOxbDOc9qZu6s1RSKg7BcfXzt0MBBD6TRAs5oUQL1f7R45sdKRN5D5Byou7xuhSOT9A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043033"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway"><img alt="Research paper thumbnail of Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/116784480/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway">Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway</a></div><div class="wp-workCard_item"><span>Cell death & disease</span><span>, Jan 23, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells. Whether Lxn functions as a tumor suppressor in leukemia and what molecular and cellular mechanisms are involved are unknown. In this study, the myeloid leukemogenic FDC-P1 cell line was used as a model system and Lxn was ectopically expressed in these cells. Using the protein pull-down assay and mass spectrometry, ribosomal protein subunit 3 (Rps3) was identified as a novel Lxn binding protein. Ectopic expression of Lxn inhibited FDC-P1 growth in vitro. More surprisingly, Lxn enhanced gamma irradiation-induced DNA damages and induced cell-cycle arrest and massive necrosis, leading to depletion of FDC-P1 cells. Mechanistically, Lxn inhibited the nuclear translocation of Rps3 upon radiation, resulting in abnormal mitotic spindle formation ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78b5aba0171aef445924e10a953ef16a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784480,"asset_id":122043033,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784480/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043033"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043033"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043033; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043033]").text(description); $(".js-view-count[data-work-id=122043033]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043033; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043033']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78b5aba0171aef445924e10a953ef16a" } } $('.js-work-strip[data-work-id=122043033]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043033,"title":"Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway","internal_url":"https://www.academia.edu/122043033/Latexin_sensitizes_leukemogenic_cells_to_gamma_irradiation_induced_cell_cycle_arrest_and_cell_death_through_Rps3_pathway","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784480,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784480/thumbnails/1.jpg","file_name":"cddis2014443.pdf","download_url":"https://www.academia.edu/attachments/116784480/download_file","bulk_download_file_name":"Latexin_sensitizes_leukemogenic_cells_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784480/cddis2014443-libre.pdf?1720980923=\u0026response-content-disposition=attachment%3B+filename%3DLatexin_sensitizes_leukemogenic_cells_to.pdf\u0026Expires=1740391655\u0026Signature=NguDOHCOivRcC2Y2o4gEh1OqiwyNb4QtEL9nV2MgNv5ge7lKHDOwCgKu~yOCD-MiUB3s4G1CTSDsiHBWdfQKKZo4Yt-ujT-d4IVXJEShsq3g5JOrLI2SgXmXx7Cwx~-jAtWMSGqLVij5OxqfT5TWHepqOEB5DFR8t8K6jxK6ws-~gdpwVTXyb-AAntxNNv2WZnSdvivawZqoYEnBaQD5EcRnvg7x1HND-6j67T~~tHrVFrnGouNAhwDLQPkIKe4xsSWZTQxaGjkKTDHLk2LP1PLO901PhvhOLDEqnbzxgpyYnx8KoLbPRibAX-c8g1Sz5o8IH7yvqoTmZR01JQ8bHA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043032"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy"><img alt="Research paper thumbnail of Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy">Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy</a></div><div class="wp-workCard_item"><span>Radiation Research</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Martin Hauer-Jensen, Konrad K. Richter, Junru Wang, Etsuko Abe, Ching-Ching Sung and James W....</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Martin Hauer-Jensen, Konrad K. Richter, Junru Wang, Etsuko Abe, Ching-Ching Sung and James W. Hardin Departments of Surgery, Medicine and Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043032; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043032]").text(description); $(".js-view-count[data-work-id=122043032]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043032; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043032']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043032]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043032,"title":"Changes in Transforming Growth Factor β1 Gene Expression and Immunoreactivity Levels during Development of Chronic Radiation Enteropathy","internal_url":"https://www.academia.edu/122043032/Changes_in_Transforming_Growth_Factor_%CE%B21_Gene_Expression_and_Immunoreactivity_Levels_during_Development_of_Chronic_Radiation_Enteropathy","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043031"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity"><img alt="Research paper thumbnail of Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity" class="work-thumbnail" src="https://attachments.academia-assets.com/116852859/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity">Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity</a></div><div class="wp-workCard_item"><span>Nature Medicine</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">AUTHOR CONTRIBUTION H. Geiger, designed and performed experiments, wrote the paper S.A. Pawar, co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">AUTHOR CONTRIBUTION H. Geiger, designed and performed experiments, wrote the paper S.A. Pawar, collected, analyzed, and summarized data E.J. Kerschen, performed experiments K. Nattamai, performed experiments, wrote parts of the paper I. Hernandez, performed experiments H.P. Liang, performed experiments J. A. Fernandez, provided reagents and advised on experimental design J.A. Cancelas, performed experiments M.A. Ryan, performed experiments O. Kustikova, advised on experimental design and provided experimental expertise A. Schambach, advised on experimental design and provided reagents Q. Fu, performed in vivo studies J. Wang, performed in vitro studies L.M. Fink, advised on experimental design and participated in writing the manuscript K-U. Petersen, performed PK studies with solulin and advised on experimental details D. Zhou, advised on experimental design and provided experimental expertise J. H. Griffin, provided reagents and advised on experimental design C. Baum, advised on experimental design and provided experimental expertise H. Weiler, designed and performed experiments, wrote the paper M. Hauer-Jensen, designed experiments, wrote the paper</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="26ead6672439f0805e71bba7e7e03ebb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116852859,"asset_id":122043031,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116852859/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043031"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043031"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043031; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043031]").text(description); $(".js-view-count[data-work-id=122043031]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043031; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043031']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "26ead6672439f0805e71bba7e7e03ebb" } } $('.js-work-strip[data-work-id=122043031]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043031,"title":"Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity","internal_url":"https://www.academia.edu/122043031/Pharmacological_targeting_of_the_thrombomodulin_activated_protein_C_pathway_mitigates_radiation_toxicity","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116852859,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116852859/thumbnails/1.jpg","file_name":"pmc3491776.pdf","download_url":"https://www.academia.edu/attachments/116852859/download_file","bulk_download_file_name":"Pharmacological_targeting_of_the_thrombo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116852859/pmc3491776-libre.pdf?1721227302=\u0026response-content-disposition=attachment%3B+filename%3DPharmacological_targeting_of_the_thrombo.pdf\u0026Expires=1740391655\u0026Signature=V-vODytfPd-RPbp-Dnue2n~DQULOHsSitg3Q7won6KFg5-nt4jYazezBwaw4TAwIU3FaahzpMXXmziiPV73694Uuh78w2JR5oFGeLlrju0w-OddycuOL572uD07Noj2tPfM-6835GKh4GuomBtqnGpxAOIQfX3JSxd~DWZu7xP3DCIQ6PyBRTCqwLf9sk4JNhwX5NgPypTPIzfhqUMrAv4xfu8rftsp-IUEGR4C0X5VTn2Re6uWVWVhLhnv7yzhBv0E5T49S0GLvd8ACvoUXTNK~sF73o1D0gLP4zXAYrpOK5LqfO3IF9wonEnMEZv-7gZXJldGwg5rI5vWgA1bznw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin"><img alt="Research paper thumbnail of Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin" class="work-thumbnail" src="https://attachments.academia-assets.com/116784438/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin">Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin</a></div><div class="wp-workCard_item"><span>Current Drug Targets</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="136a904f4e404d3fd2464eb0e21b7b1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116784438,"asset_id":122043030,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116784438/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043030]").text(description); $(".js-view-count[data-work-id=122043030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "136a904f4e404d3fd2464eb0e21b7b1a" } } $('.js-work-strip[data-work-id=122043030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043030,"title":"Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin","internal_url":"https://www.academia.edu/122043030/Novel_Strategies_to_Ameliorate_Radiation_Injury_A_Possible_Role_for_Tetrahydrobiopterin","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[{"id":116784438,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784438/thumbnails/1.jpg","file_name":"72533.txt","download_url":"https://www.academia.edu/attachments/116784438/download_file","bulk_download_file_name":"Novel_Strategies_to_Ameliorate_Radiation.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784438/72533.txt?1720976984=\u0026response-content-disposition=attachment%3B+filename%3DNovel_Strategies_to_Ameliorate_Radiation.txt\u0026Expires=1740391655\u0026Signature=VJTy4q~5mKgcABSzdeypIJwwrh96k3CnUW2QhWKBL-OJA2q3QaBss8vE0dpM500H1XZX9S-ZbPlzWV2EykBPQTF4TGJDBkO~Wl6O5FJ2vsRcP6hQiNk7k1HvwvR~L~0qL8E9FOAX6m9dzVAgcIBA6x46l97LqvFGha-rz1DxSEVyuX-kao9skGRBFFTaafNm0Z5GigR0zSPmkpL2Cxw-rdOikdG6J7ma9FmhZi3AysNqkNJbif7nGDtdsux-DONKDD4fx7UZRGMlMSZfJ22n-a4FAv7P6WUJR5LwM-tIq4gHgOabiPokBlUok5niGoUbGqLorPu6GXc~EnrVCGS~aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116784437,"title":"","file_type":"txt","scribd_thumbnail_url":"https://attachments.academia-assets.com/116784437/thumbnails/1.jpg","file_name":"72533.txt","download_url":"https://www.academia.edu/attachments/116784437/download_file","bulk_download_file_name":"Novel_Strategies_to_Ameliorate_Radiation.txt","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116784437/72533.txt?1720976984=\u0026response-content-disposition=attachment%3B+filename%3DNovel_Strategies_to_Ameliorate_Radiation.txt\u0026Expires=1740391655\u0026Signature=NzVOk94uUFvGz72c6vHAnJ7PSyknj9VZcl7xTf~lqywDoypHnWmw0FqCXmxmHpBJvlbLaUzn6BgMe5i2PC~qKjBiM8OGVMW078hHJpasLoh~LEx3Liyn4~HdnguBIFuKWoyaeFxToW2TI-wVIUcvq~N0tLeAGPeW8~RMBENmNalKrVYNfZFIxqCKgG0ALgmj~9Y9E1NPTFtJY1n~VAmleBPV3O8RhXgpWshVUOIaLUPz3-zxz5gtW2s~46sSAqqNNie-zqVunRb9FHpp3xEvg8fdVPjSWTiIQMuh-bEUF63B-JVbbfj-eM1PtYxcVKEwrxcordsZz92uzCT4JKQDtw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122043029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia"><img alt="Research paper thumbnail of Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia">Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia</a></div><div class="wp-workCard_item"><span>Blood Coagulation & Fibrinolysis</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Thrombomodulin (TM) plays an important role in anticoagulation by forming a complex with thrombin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Thrombomodulin (TM) plays an important role in anticoagulation by forming a complex with thrombin, which subsequently activates protein C. TM is inactivated and downregulated by inflammatory cell mediators. This study examined whether bronchopneumonia is associated with changes in TM immunoreactivity, and whether a decrease in TM is accompanied by evidence of hypercoagulability, i.e. local deposition of fibrin. Double antibody staining for TM and fibrin was performed on lung tissue sections from patients who had died of pneumonia and from patients who had died rapidly, secondary to trauma. Inflammatory changes were assessed histologically and immunohistochemically using antibodies against interleukin-1alpha, tumor necrosis factor-alpha, and myeloperoxidase. Areas with bronchopneumonia exhibited markedly decreased endothelial TM staining of alveolar walls and small vessels. These changes were associated with prominent fibrin immunoreactivity. Some areas exhibited mild to moderate inflammation with little fibrin deposition and variable amounts of TM in adjacent vessels. This study is the first to relate changes of TM immunoreactivity levels to fibrin deposition in a human disease process. These data may have implications for pulmonary pathophysiology in patients with bronchopneumonia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122043029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122043029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122043029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122043029]").text(description); $(".js-view-count[data-work-id=122043029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122043029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122043029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122043029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122043029,"title":"Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumonia","internal_url":"https://www.academia.edu/122043029/Association_between_decreased_pulmonary_endothelial_cell_thrombomodulin_and_local_fibrin_deposition_in_pneumonia","owner_id":33653594,"coauthors_can_edit":true,"owner":{"id":33653594,"first_name":"Martin","middle_initials":null,"last_name":"Hauer-jensen","page_name":"MartinHauerjensen","domain_name":"independent","created_at":"2015-08-05T18:22:01.774-07:00","display_name":"Martin Hauer-jensen","url":"https://independent.academia.edu/MartinHauerjensen"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "316606d3b0f928bc7a882b01d379e05cb3aa65caa088ca52a23159f4f6870b5e", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="KxdJZOjSB79xSFyM4g5GKLjJA8slwRBKgroDKlWhFSVTMRAaFMiUBHehj83igQ8XHZnxP_EJ0d-otOxxl_0PAQ" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/MartinHauerjensen" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="nc1hKBBj6b8q97UUpa3oF-TAQsLUkeiPtb7teoVk1FLl6zhW7Hl6BCweZlWlIqEoQZCwNgBZKRqfsAIhRzjOdg" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>