CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Yisheng Lee - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="a3cgDIqhS6FeBDKCNnn2i4Xp8/Q03LnuHRoUAJ3OQ8LmrJquHtareu12Nol0dLLgyBuhgRVdptnenfAv6ueYlw==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-1c712297ae3ac71207193b1bae0ecf1aae125886850f62c9c0139dd867630797.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="yisheng lee" /> <meta name="description" content="Yisheng Lee: 3 Following, 18 Research papers. Research interests: Cardiovascular medicine and haematology and Clinical Sciences." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '640e319a5feb821ef61cccaf77c34b260ff56349'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15272,"monthly_visitors":"113 million","monthly_visitor_count":113784677,"monthly_visitor_count_in_millions":113,"user_count":277488091,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732744957000); window.Aedu.timeDifference = new Date().getTime() - 1732744957000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-296162c7af6fd81dcdd76f1a94f1fad04fb5f647401337d136fe8b68742170b1.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-7734a8b54dedb8fefe75ef934203d0ef41d066c1c5cfa6ba2a13dd7ec8bce449.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-9eaa790b1139e2d88eb4ac931dcbc6d7cea4403a763db5cc5a695dd2eaa34151.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/YishengLee5" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-533ab26e53b28997c1064a839643ef40d866d497c665279ed26b743aacb62042.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/YishengLee5","location":"/YishengLee5","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/YishengLee5","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-f991f4fe-0a42-45a8-8f55-597e61ec1acb"></div> <div id="ProfileCheckPaperUpdate-react-component-f991f4fe-0a42-45a8-8f55-597e61ec1acb"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Yisheng Lee</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Yisheng" data-follow-user-id="231568456" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="231568456"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">0</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">3</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="231568456" href="https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/YishengLee5","location":"/YishengLee5","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/YishengLee5","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Cardiovascular medicine and haematology"]}" data-trace="false" data-dom-id="Pill-react-component-933ff998-213c-47a3-afa5-c4947c838eab"></div> <div id="Pill-react-component-933ff998-213c-47a3-afa5-c4947c838eab"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="231568456" href="https://www.academia.edu/Documents/in/Clinical_Sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Clinical Sciences"]}" data-trace="false" data-dom-id="Pill-react-component-c208733f-1153-42dc-b7f3-cd14614a8cbc"></div> <div id="Pill-react-component-c208733f-1153-42dc-b7f3-cd14614a8cbc"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Yisheng Lee</h3></div><div class="js-work-strip profile--work_container" data-work-id="121154712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects"><img alt="Research paper thumbnail of Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects">Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects</a></div><div class="wp-workCard_item"><span>Allergy and immunology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154712]").text(description); $(".js-view-count[data-work-id=121154712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154712, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121154712]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154712,"title":"Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects","translated_title":"","metadata":{"publisher":"European Respiratory Society","publication_name":"Allergy and immunology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects","translated_internal_url":"","created_at":"2024-06-17T16:18:11.723-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[{"id":43021062,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2023.OA2494"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121154711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies"><img alt="Research paper thumbnail of Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies">Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, Dec 1, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154711]").text(description); $(".js-view-count[data-work-id=121154711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154711, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121154711]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154711,"title":"Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies","translated_title":"","metadata":{"abstract":"A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.","publisher":"Elsevier BV","publication_date":{"day":1,"month":12,"year":1986,"errors":{}},"publication_name":"Journal of Neuroimmunology"},"translated_abstract":"A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.","internal_url":"https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies","translated_internal_url":"","created_at":"2024-06-17T16:18:11.527-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3398462,"name":"epitope","url":"https://www.academia.edu/Documents/in/epitope"}],"urls":[{"id":43021061,"url":"https://doi.org/10.1016/0165-5728(86)90065-2"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121154710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects"><img alt="Research paper thumbnail of First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects" class="work-thumbnail" src="https://attachments.academia-assets.com/116110832/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects">First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects</a></div><div class="wp-workCard_item"><span>Clinical Drug Investigation</span><span>, Dec 17, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c692546bc93031df4ed7e19ed06de377" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116110832,"asset_id":121154710,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154710]").text(description); $(".js-view-count[data-work-id=121154710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154710, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c692546bc93031df4ed7e19ed06de377" } } $('.js-work-strip[data-work-id=121154710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154710,"title":"First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects","translated_title":"","metadata":{"publisher":"Adis, Springer Healthcare","grobid_abstract":"Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.","publication_date":{"day":17,"month":12,"year":2020,"errors":{}},"publication_name":"Clinical Drug Investigation","grobid_abstract_attachment_id":116110832},"translated_abstract":null,"internal_url":"https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects","translated_internal_url":"","created_at":"2024-06-17T16:18:11.290-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116110832,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110832/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110832/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=Vl~W6k0lg4mjKDrd~CXdYcNew41MeUnp52~yzhBrJL8CkCP2XdZTUtWQoU-ed2Uuln0Lj-bKss8~4oZ74REE8mu1naIrxZ4Zcb7VrST3zprtL81dlTKc4ZRGMKqHerFoedj-EhTN0rCGvzPtWvBSXPmwgxKd7wOjiuqus0s6S0clztK129DthU7quqgMA5bWpA1tt9cgnaUKDWNwxtOcETDEK9ISK2-JteD62Hbp21eVj5GE1DPdoSZWOnIeZDybARehQJzXMzpRRLRFWnE~Uhug~xLAgAZ4WmNg7jny0f04wupzqR4aOcGKJjPLRtdt7DcP9Pq08DK3djPgnrc57w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":116110832,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110832/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110832/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=Vl~W6k0lg4mjKDrd~CXdYcNew41MeUnp52~yzhBrJL8CkCP2XdZTUtWQoU-ed2Uuln0Lj-bKss8~4oZ74REE8mu1naIrxZ4Zcb7VrST3zprtL81dlTKc4ZRGMKqHerFoedj-EhTN0rCGvzPtWvBSXPmwgxKd7wOjiuqus0s6S0clztK129DthU7quqgMA5bWpA1tt9cgnaUKDWNwxtOcETDEK9ISK2-JteD62Hbp21eVj5GE1DPdoSZWOnIeZDybARehQJzXMzpRRLRFWnE~Uhug~xLAgAZ4WmNg7jny0f04wupzqR4aOcGKJjPLRtdt7DcP9Pq08DK3djPgnrc57w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116110833,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110833/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110833/download_file","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110833/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=G2pBat0W5-0fuk~IYHw2MduiX3-iE8zcmkNBpYkPOzsRReM99AvJ9JvkpPYDt-~1ycJy1zRpJAqOzJf6EvBwdrtxDDX2P7ox8iCivocvT75nenbBwpogfLFk91oaUZC40RfayBXhZOoaPPu~GBT-07X46KI4OQCav0HrFq7sTkknnKQ36dfye7i7B5yHp4RqfxuuoLkN9Fl6CAHU2V5AljtHXogbqFRB5tRrgBKyR5wE-c2x8lOOVI-FdUU65P~cBKhCmrxs1EUOnh8rc54hzCanvw2e0EvdCNxd5r-PyquuOrtqfm7ZwB1D9bHKMSg3foBqhvKDIqytwGbRAg1VvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":11111,"name":"Pharmacokinetics","url":"https://www.academia.edu/Documents/in/Pharmacokinetics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":89956,"name":"Pharmaceutical Sciences","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Sciences"},{"id":612887,"name":"Capsule","url":"https://www.academia.edu/Documents/in/Capsule"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect"},{"id":2641150,"name":"Tolerability","url":"https://www.academia.edu/Documents/in/Tolerability"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":43021060,"url":"https://pure.rug.nl/ws/files/632784246/s40261_020_00981_9.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996464"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology"><img alt="Research paper thumbnail of The Applications of Monoclonal Antibodies in Neuro-Oncology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology">The Applications of Monoclonal Antibodies in Neuro-Oncology</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. M...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996464"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996464"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996464; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996464]").text(description); $(".js-view-count[data-work-id=90996464]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996464; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996464']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996464, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996464]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996464,"title":"The Applications of Monoclonal Antibodies in Neuro-Oncology","translated_title":"","metadata":{"abstract":"Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}}},"translated_abstract":"Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.","internal_url":"https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology","translated_internal_url":"","created_at":"2022-11-17T06:37:32.142-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients"><img alt="Research paper thumbnail of A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients" class="work-thumbnail" src="https://attachments.academia-assets.com/94406936/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients">A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients</a></div><div class="wp-workCard_item"><span>World Journal of Urology</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="135ddbd546037bdd2a95dc872d2c613d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406936,"asset_id":90996455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996455; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996455]").text(description); $(".js-view-count[data-work-id=90996455]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996455; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996455']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996455, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "135ddbd546037bdd2a95dc872d2c613d" } } $('.js-work-strip[data-work-id=90996455]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996455,"title":"A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Objectives To determine the safety, efficacy and pharmacokinetic (PK) profile of a pre-mixed depot formulation of leuprolide mesylate subcutaneous injectable suspension (LMIS) 50 mg for up to 1 year of treatment for subjects with advanced prostate cancer. Patients and methods In this open-label, multicenter study, prostate cancer patients with indication for androgen ablation therapy received two subcutaneous injection of LMIS 50 mg 6 months apart and were followed for an additional 6 months. Two efficacy primary end points were the percentage of subjects with a serum testosterone level ≤ 50 ng/dL by Day 28 as well as the percentage of subjects with similar testosterone suppression from Day 28 to Day 336. Results Of the 137 enrolled subjects, 15 (10.9%) subjects did not complete the study, including 5 subjects who terminated early due to an adverse event. By Day 28, 98.5% (95% confidence interval 94.8-99.8) of the subjects achieved a castrate testosterone level. At the end of the study, 97% and 95.9% of the subjects had serum testosterone level ≤ 50 ng/dL and ≤ 20 ng/ dL, respectively. LMIS 50 mg significantly reduced serum prostate-specific antigen levels after its first injection and this PSA declination effect remained until the end of the study. No statistically significant change was observed in worsening bone pain or urinary symptom assessments during the study. Hot flush (48.9%) and hypertension (14.6%) were the two most common adverse events reported. Conclusions LMIS 50 mg, administered at 6-month intervals, effectively suppressed serum testosterone level, and demonstrated a consistent safety profile.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"World Journal of Urology","grobid_abstract_attachment_id":94406936},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients","translated_internal_url":"","created_at":"2022-11-17T06:37:26.018-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406936/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406936/s00345-019-02741-7-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=ElWae4lUYuwFPOo8LLIbpi0IG3yyBMIyJhsqezZZJswoV8wVJ-E9IcwzPT23YqA66gDOwu0cE6BJrEsagsibo8tiibtX3QHovb~EWRpPwdXJymi4NFSTHM3IFSsV5EFwcutksNJfMIwreZpHUDRJLZ3wU4FdAeGxgPchZ-VG2HBUBNavLIUP6JE7CmesEpJHWHm9J5ne1fhJCNCPfc681CMMIiqEcvs0OvbNh0353YDII5nwmj0~7YCyoBim1hDzefl3QrSTXI7PlVhxYr6uUs3dWjbgRuJ~hhrq59bB3xNsd43Wj8CszAk80GnSCHyM324DC2JFf04Isr6uM0pfwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406936/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406936/s00345-019-02741-7-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=ElWae4lUYuwFPOo8LLIbpi0IG3yyBMIyJhsqezZZJswoV8wVJ-E9IcwzPT23YqA66gDOwu0cE6BJrEsagsibo8tiibtX3QHovb~EWRpPwdXJymi4NFSTHM3IFSsV5EFwcutksNJfMIwreZpHUDRJLZ3wU4FdAeGxgPchZ-VG2HBUBNavLIUP6JE7CmesEpJHWHm9J5ne1fhJCNCPfc681CMMIiqEcvs0OvbNh0353YDII5nwmj0~7YCyoBim1hDzefl3QrSTXI7PlVhxYr6uUs3dWjbgRuJ~hhrq59bB3xNsd43Wj8CszAk80GnSCHyM324DC2JFf04Isr6uM0pfwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":94406937,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406937/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406937/download_file","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406937/s00345-019-02741-7-libre.pdf?1668696091=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=OhQic3y~QiJA-N7fyibHli~V~vqeCS088pwhOqmJXEBI09loN-YKjv~wqhCdXTCRI46EgAgB0WV4ACIcj6-GcXo~OFqnf67aKhcM3mHzowrg2R5acfJG0jQd991~F1jWM~PgJiyltSx3XtdfiEjBtweCnikasgNP-v3Drn73ES3VUHXM~-XCYFa1NLtbodLdNcP6S-2V6f~PvG9g3DwZRnoIF0UK2GRU1I--xIYDOiaGkuqOrYQYfL~xKNpW6J2AjX~oXFXSbTrYAgxB9YOgSQ~ocW1kWiZn~Q4aSC~DhQPsDqzts11X7pGA1DuFeiNpMx18c02ZlOue2VtF3ww9Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[{"id":26082049,"url":"http://link.springer.com/content/pdf/10.1007/s00345-019-02741-7.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996442"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas"><img alt="Research paper thumbnail of Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas" class="work-thumbnail" src="https://attachments.academia-assets.com/94406996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas">Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas</a></div><div class="wp-workCard_item"><span>Neurologic Clinics</span><span>, 1985</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0519dda9f32550cb2ba6ca1052252d3f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406996,"asset_id":90996442,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996442"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996442"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996442; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996442]").text(description); $(".js-view-count[data-work-id=90996442]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996442; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996442']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996442, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0519dda9f32550cb2ba6ca1052252d3f" } } $('.js-work-strip[data-work-id=90996442]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996442,"title":"Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Neurologic Clinics"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas","translated_internal_url":"","created_at":"2022-11-17T06:37:20.612-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406996,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406996/thumbnails/1.jpg","file_name":"s0733-8619_2818_2931221-020221117-1-1x6akdf.pdf","download_url":"https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Aspects_of_Immunobiology_and_Immunothera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406996/s0733-8619_2818_2931221-020221117-1-1x6akdf-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DAspects_of_Immunobiology_and_Immunothera.pdf\u0026Expires=1732748557\u0026Signature=I0wHUWfGac3WT8wajhL9z5-v9O8ZK6xU4ZpuHeIj9aQRCuu-BNM4yuXn3eiJac41JzI2UZqJC-99XOKb0YGJ0oSoEEHvRAR7yniJ2GzBHv~Hkfr4cyn2EnTp6YFvuH5XIyQlltYzRdwxewxT7xDvEmZmFNmlomMBl-4dQAxPqnB46zzbhSmLXVEBJDBaM7eOss7Oiif7yiKgiW43gks~nILd1awTcqVZnTA5RETQ~KSxqK7YIZmcrwZkFZfUI-vGHPyOBolObibm1DqTkmt87WKD2r6esuU9HSa3swqvQQbKkfBn2~iujimRKfpc5aIM~Fka3OcL670mOiEmciv1aQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406996,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406996/thumbnails/1.jpg","file_name":"s0733-8619_2818_2931221-020221117-1-1x6akdf.pdf","download_url":"https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Aspects_of_Immunobiology_and_Immunothera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406996/s0733-8619_2818_2931221-020221117-1-1x6akdf-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DAspects_of_Immunobiology_and_Immunothera.pdf\u0026Expires=1732748557\u0026Signature=I0wHUWfGac3WT8wajhL9z5-v9O8ZK6xU4ZpuHeIj9aQRCuu-BNM4yuXn3eiJac41JzI2UZqJC-99XOKb0YGJ0oSoEEHvRAR7yniJ2GzBHv~Hkfr4cyn2EnTp6YFvuH5XIyQlltYzRdwxewxT7xDvEmZmFNmlomMBl-4dQAxPqnB46zzbhSmLXVEBJDBaM7eOss7Oiif7yiKgiW43gks~nILd1awTcqVZnTA5RETQ~KSxqK7YIZmcrwZkFZfUI-vGHPyOBolObibm1DqTkmt87WKD2r6esuU9HSa3swqvQQbKkfBn2~iujimRKfpc5aIM~Fka3OcL670mOiEmciv1aQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":485569,"name":"Glial Fibrillary Acidic Protein","url":"https://www.academia.edu/Documents/in/Glial_Fibrillary_Acidic_Protein"},{"id":637718,"name":"Nervous System","url":"https://www.academia.edu/Documents/in/Nervous_System"},{"id":868560,"name":"Lymphocytes","url":"https://www.academia.edu/Documents/in/Lymphocytes"},{"id":894787,"name":"Immune Tolerance","url":"https://www.academia.edu/Documents/in/Immune_Tolerance"},{"id":1159038,"name":"Epitopes","url":"https://www.academia.edu/Documents/in/Epitopes"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1274458,"name":"Antigens","url":"https://www.academia.edu/Documents/in/Antigens"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[{"id":26082044,"url":"https://api.elsevier.com/content/article/PII:S0733861918312210?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996435"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration"><img alt="Research paper thumbnail of Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration" class="work-thumbnail" src="https://attachments.academia-assets.com/94406988/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration">Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="41ba888e4232af22b388f0a9bf2de0c6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406988,"asset_id":90996435,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996435"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996435"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996435; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996435]").text(description); $(".js-view-count[data-work-id=90996435]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996435; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996435']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996435, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "41ba888e4232af22b388f0a9bf2de0c6" } } $('.js-work-strip[data-work-id=90996435]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996435,"title":"Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration","translated_title":"","metadata":{"abstract":"Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","internal_url":"https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration","translated_internal_url":"","created_at":"2022-11-17T06:37:16.893-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406988,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406988/thumbnails/1.jpg","file_name":"1941.full.pdf","download_url":"https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_of_monoclonal_antibody_delive.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406988/1941.full-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DComparison_of_monoclonal_antibody_delive.pdf\u0026Expires=1732748557\u0026Signature=D1L1IUe04R-mOKES60fEranMTNZ7sZnCZdOr0PSHps2vipplyCSijq4o5UZeFdNWETOr4jzS~UFga~e2B71eTBEraXxgXow-kTJbhCcDG8aXvRTHxDAIxRDvo8i1DXwEQyJYWINNNuAN54KiGhak99BGI7lEKh~SKFifyti5DtmVErZFe2o2D7F5bODuR6xnM04ZxAGoNm-iGlr5UfjCMQDFw1I~X0NI9pus30nmz2Nz4wxfvJwT7ANXwQrTxkcFRnQcJClKOgp4mlFSL6D3cnLeLJ8jUCBR5MmKp9gF3b7cr1nirTz2zc49hiAkLF8fJ6yMxoFuX-0lTp0REg44BA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406988,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406988/thumbnails/1.jpg","file_name":"1941.full.pdf","download_url":"https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_of_monoclonal_antibody_delive.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406988/1941.full-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DComparison_of_monoclonal_antibody_delive.pdf\u0026Expires=1732748557\u0026Signature=D1L1IUe04R-mOKES60fEranMTNZ7sZnCZdOr0PSHps2vipplyCSijq4o5UZeFdNWETOr4jzS~UFga~e2B71eTBEraXxgXow-kTJbhCcDG8aXvRTHxDAIxRDvo8i1DXwEQyJYWINNNuAN54KiGhak99BGI7lEKh~SKFifyti5DtmVErZFe2o2D7F5bODuR6xnM04ZxAGoNm-iGlr5UfjCMQDFw1I~X0NI9pus30nmz2Nz4wxfvJwT7ANXwQrTxkcFRnQcJClKOgp4mlFSL6D3cnLeLJ8jUCBR5MmKp9gF3b7cr1nirTz2zc49hiAkLF8fJ6yMxoFuX-0lTp0REg44BA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":249714,"name":"Biodistribution","url":"https://www.academia.edu/Documents/in/Biodistribution"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":967378,"name":"Radioisotopes","url":"https://www.academia.edu/Documents/in/Radioisotopes"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996428"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6"><img alt="Research paper thumbnail of Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6" class="work-thumbnail" src="https://attachments.academia-assets.com/94406986/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6">Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, Jan 15, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. T...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3459763f19404861aafd451d9c53c79f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406986,"asset_id":90996428,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996428"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996428; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996428]").text(description); $(".js-view-count[data-work-id=90996428]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996428; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996428']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996428, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3459763f19404861aafd451d9c53c79f" } } $('.js-work-strip[data-work-id=90996428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996428,"title":"Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6","translated_title":"","metadata":{"abstract":"Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...","publication_date":{"day":15,"month":1,"year":1988,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...","internal_url":"https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6","translated_internal_url":"","created_at":"2022-11-17T06:37:13.088-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406986,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406986/thumbnails/1.jpg","file_name":"2904.full.pdf","download_url":"https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_intracranial_human_glioma_x.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406986/2904.full-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_intracranial_human_glioma_x.pdf\u0026Expires=1732748557\u0026Signature=DYCdMPyxz~g0Tg8WHj~Hu6a5aHW06cBHEfOHvY6c~ZTAQbtCEhGJkSroqzYog9rG2KpFAGzLbpcycBvQt3IKOTr2DBK7SmqTqpADaKoeB7AWifbAhSFY5aD2oCMr8SONH27O0ZM6oUs03JHmOAeQ1WXJfqtqFH0Yoz1gP39DCKPBUp0cjBrmO8NJ4FQIvEvWeuousGJv1Z4r8Mu8JUcCcIH9vaILwQn~v0B8IR8EDj9f8O4Opzurt0GYllExFhqF1zAk1pi314aaqsFd-8fHiREsWneK0lr87e9WvqjeJeJLMSYFk15MvVANtHaCE9e-PofXsCLdIwoNykKhl7pj-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406986,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406986/thumbnails/1.jpg","file_name":"2904.full.pdf","download_url":"https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_intracranial_human_glioma_x.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406986/2904.full-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_intracranial_human_glioma_x.pdf\u0026Expires=1732748557\u0026Signature=DYCdMPyxz~g0Tg8WHj~Hu6a5aHW06cBHEfOHvY6c~ZTAQbtCEhGJkSroqzYog9rG2KpFAGzLbpcycBvQt3IKOTr2DBK7SmqTqpADaKoeB7AWifbAhSFY5aD2oCMr8SONH27O0ZM6oUs03JHmOAeQ1WXJfqtqFH0Yoz1gP39DCKPBUp0cjBrmO8NJ4FQIvEvWeuousGJv1Z4r8Mu8JUcCcIH9vaILwQn~v0B8IR8EDj9f8O4Opzurt0GYllExFhqF1zAk1pi314aaqsFd-8fHiREsWneK0lr87e9WvqjeJeJLMSYFk15MvVANtHaCE9e-PofXsCLdIwoNykKhl7pj-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":74479,"name":"Isotype","url":"https://www.academia.edu/Documents/in/Isotype"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":2921967,"name":"Tenascin","url":"https://www.academia.edu/Documents/in/Tenascin"},{"id":2950651,"name":"Tissue distribution","url":"https://www.academia.edu/Documents/in/Tissue_distribution"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model"><img alt="Research paper thumbnail of Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model" class="work-thumbnail" src="https://attachments.academia-assets.com/94407015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model">Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The development of Mabs, particularly those reactive with primary brain tumors but not with norma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1dfcbbe29fb10d439e9f64763a99731d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94407015,"asset_id":90996422,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996422; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996422]").text(description); $(".js-view-count[data-work-id=90996422]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996422; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996422']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996422, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1dfcbbe29fb10d439e9f64763a99731d" } } $('.js-work-strip[data-work-id=90996422]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996422,"title":"Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model","translated_title":"","metadata":{"abstract":"The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...","internal_url":"https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model","translated_internal_url":"","created_at":"2022-11-17T06:37:09.043-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94407015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407015/thumbnails/1.jpg","file_name":"559.full.pdf","download_url":"https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_efficacy_of_antiglioma_mesen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407015/559.full-libre.pdf?1668696086=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_efficacy_of_antiglioma_mesen.pdf\u0026Expires=1732748557\u0026Signature=L-QPTxmjM9dnOgOVaLKjAb4bLM5uauXl1lJB3aAWWMRERB~5QHXPPdlM4LzuQ18sz4ZNZ-BxRMFQ02Hd-l4DsbQju8eaXYEhKLfafJN2bVhhXr3zaZ~b6MNZDGJcvU1sq-ZvRb4-~TIVaweQr1lXoD~sBDIZlZQs52JCx5NQqeM4ov~gpdfX8NgpxAMSFmAi2C7W1UyglZIoSrOrOZYm04ii817ehnk3SkZgshgjDo24IDRvH5tBtCLMSBSp~IwSlcP1aO4RouSJYRYxNC6jFGRyw7AFFMjguh2~51th8RprLxVoogGpF04AUWBOnIcxFjPFcktpcnYJuupsulaXAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94407015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407015/thumbnails/1.jpg","file_name":"559.full.pdf","download_url":"https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_efficacy_of_antiglioma_mesen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407015/559.full-libre.pdf?1668696086=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_efficacy_of_antiglioma_mesen.pdf\u0026Expires=1732748557\u0026Signature=L-QPTxmjM9dnOgOVaLKjAb4bLM5uauXl1lJB3aAWWMRERB~5QHXPPdlM4LzuQ18sz4ZNZ-BxRMFQ02Hd-l4DsbQju8eaXYEhKLfafJN2bVhhXr3zaZ~b6MNZDGJcvU1sq-ZvRb4-~TIVaweQr1lXoD~sBDIZlZQs52JCx5NQqeM4ov~gpdfX8NgpxAMSFmAi2C7W1UyglZIoSrOrOZYm04ii817ehnk3SkZgshgjDo24IDRvH5tBtCLMSBSp~IwSlcP1aO4RouSJYRYxNC6jFGRyw7AFFMjguh2~51th8RprLxVoogGpF04AUWBOnIcxFjPFcktpcnYJuupsulaXAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":51883,"name":"Brain Tumor","url":"https://www.academia.edu/Documents/in/Brain_Tumor"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":151951,"name":"Animal Model","url":"https://www.academia.edu/Documents/in/Animal_Model"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":389506,"name":"Radiation Dose","url":"https://www.academia.edu/Documents/in/Radiation_Dose"},{"id":399886,"name":"Specific Activity","url":"https://www.academia.edu/Documents/in/Specific_Activity"},{"id":573989,"name":"Malignant Glioma","url":"https://www.academia.edu/Documents/in/Malignant_Glioma"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1426712,"name":"Immunoglobulin","url":"https://www.academia.edu/Documents/in/Immunoglobulin"},{"id":1662977,"name":"Nude mice","url":"https://www.academia.edu/Documents/in/Nude_mice"},{"id":1817281,"name":"Extracellular Matrix Proteins","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix_Proteins"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996417"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma"><img alt="Research paper thumbnail of A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma">A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma</a></div><div class="wp-workCard_item"><span>Journal of Neuropathology and Experimental Neurology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996417"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996417"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996417; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996417]").text(description); $(".js-view-count[data-work-id=90996417]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996417; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996417']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996417, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996417]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996417,"title":"A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma","translated_title":"","metadata":{"abstract":"A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Journal of Neuropathology and Experimental Neurology"},"translated_abstract":"A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.","internal_url":"https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma","translated_internal_url":"","created_at":"2022-11-17T06:37:02.547-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":118793,"name":"Sarcoma","url":"https://www.academia.edu/Documents/in/Sarcoma"},{"id":153639,"name":"Karyotyping","url":"https://www.academia.edu/Documents/in/Karyotyping"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":485569,"name":"Glial Fibrillary Acidic Protein","url":"https://www.academia.edu/Documents/in/Glial_Fibrillary_Acidic_Protein"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":1757315,"name":"Injections","url":"https://www.academia.edu/Documents/in/Injections"}],"urls":[{"id":26082034,"url":"http://academic.oup.com/jnen/article-pdf/45/6/704/8136883/45-6-704.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996414"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion"><img alt="Research paper thumbnail of Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion" class="work-thumbnail" src="https://attachments.academia-assets.com/94406967/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion">Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, 1985</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ead4962114287d2fb473cb261fe156d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406967,"asset_id":90996414,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996414"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996414; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996414]").text(description); $(".js-view-count[data-work-id=90996414]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996414; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996414']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996414, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0ead4962114287d2fb473cb261fe156d" } } $('.js-work-strip[data-work-id=90996414]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996414,"title":"Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Journal of Neuroimmunology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion","translated_internal_url":"","created_at":"2022-11-17T06:36:58.533-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406967,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406967/thumbnails/1.jpg","file_name":"0165-5728_2885_2990008-620221117-1-1g60a2d.pdf","download_url":"https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Restricted_specificity_monoclonal_antibo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406967/0165-5728_2885_2990008-620221117-1-1g60a2d-libre.pdf?1668696090=\u0026response-content-disposition=attachment%3B+filename%3DRestricted_specificity_monoclonal_antibo.pdf\u0026Expires=1732748557\u0026Signature=G7LomEJwC7WopdAUzhIfRx939bVz0K-7Bsf8YWBa20wKpkJ-50F8SK1aqBQzz~Jyj07MiLw6eDYTX-E0D8hGCMHg0HBkAn2Nhfaam48HeQorgYRAKh0Ro6aqoDPJ7uKULOAIBCSV50MpEvSkG3nRa-5Nc6CaLAZnbkz~V1F8diPh2U4Nul-l7YufyBdtnsHclbC3G1OZBUEoogpzZWLioiQJtmuDXVCMpU4a1t5H8T2BYUtI~puXJzBdd7Q7yTzuFMdLYWvgMO~RWxMuEGyqR9kwUOigZ67UcWs-WU~uCAWZDMITxl2Se8hXJrBC3kc4wXt4HEgAuEEJNM3aHmkLSQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406967,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406967/thumbnails/1.jpg","file_name":"0165-5728_2885_2990008-620221117-1-1g60a2d.pdf","download_url":"https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Restricted_specificity_monoclonal_antibo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406967/0165-5728_2885_2990008-620221117-1-1g60a2d-libre.pdf?1668696090=\u0026response-content-disposition=attachment%3B+filename%3DRestricted_specificity_monoclonal_antibo.pdf\u0026Expires=1732748557\u0026Signature=G7LomEJwC7WopdAUzhIfRx939bVz0K-7Bsf8YWBa20wKpkJ-50F8SK1aqBQzz~Jyj07MiLw6eDYTX-E0D8hGCMHg0HBkAn2Nhfaam48HeQorgYRAKh0Ro6aqoDPJ7uKULOAIBCSV50MpEvSkG3nRa-5Nc6CaLAZnbkz~V1F8diPh2U4Nul-l7YufyBdtnsHclbC3G1OZBUEoogpzZWLioiQJtmuDXVCMpU4a1t5H8T2BYUtI~puXJzBdd7Q7yTzuFMdLYWvgMO~RWxMuEGyqR9kwUOigZ67UcWs-WU~uCAWZDMITxl2Se8hXJrBC3kc4wXt4HEgAuEEJNM3aHmkLSQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996410"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma"><img alt="Research paper thumbnail of Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma" class="work-thumbnail" src="https://attachments.academia-assets.com/94406968/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma">Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, 1986</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b5b7c8272788034ef457864089bfb16" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406968,"asset_id":90996410,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996410"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996410"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996410; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996410]").text(description); $(".js-view-count[data-work-id=90996410]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996410; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996410']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996410, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8b5b7c8272788034ef457864089bfb16" } } $('.js-work-strip[data-work-id=90996410]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996410,"title":"Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Summaff $69-c15 is a highly immunogenic cell line derived from an avian sarcoma virus (ASV)-induced astrocytoma in F-344 rats. Monoclonal antibody (Mab) production was attempted by fusing F-344 rat splenocytes and mouse P3 × 63/Ag8.653 myeloma cells after a syngeneic immunization protocol. 336 fusion clones were screened by cell surface radioimmunoassay (CS-RIA) against the immunizing line $69-c15, rat kidney fibroblast line $203-cll and Walker rat carcinoma line. Mabs 7G4, 9F1, 10E3 and 10E7 which reacted only with $69-c15 were chosen. Further analysis demonstrated that these Mabs reacted only with rat (13/23 astrocytomas, 2/4 gliomas, 1/11 neurinomas) or mouse (2/10 astrocytomas) neurogenic tumor cells induced by both viral and chemical agents. Reciprocal competition assays suggested that 7G4, 9F1 and 10E3 recognized the same epitope and that 10E7 reacted with a spatially close determinant. Antigen activity could not be found in adult rat tissues (brain, heart, lung, liver, kidney, spleen, thymus, intestine, muscle and peripheral nerve) and fetal brain (8, 12, 20 days gestation) by either absorption analysis or tissue staining. Preliminary characterization indicated that the epitope may be polypeptide-associated. Further antigen purification and tumor localization can be attempted with these Mabs.","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Journal of Neuroimmunology","grobid_abstract_attachment_id":94406968},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma","translated_internal_url":"","created_at":"2022-11-17T06:36:54.558-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406968/thumbnails/1.jpg","file_name":"0165-5728_2886_2990064-020221117-1-sckxlx.pdf","download_url":"https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glioma_associated_antigens_defined_by_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406968/0165-5728_2886_2990064-020221117-1-sckxlx-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DGlioma_associated_antigens_defined_by_mo.pdf\u0026Expires=1732748557\u0026Signature=aahNnUZbOShyUbxKGLFGPsTMmKVnSGha4y9wgOfaFVA7GywFKh0kbui7pwnIdvp-xIPaV~bImPOFnZUNXNIr0uhw6xjvyCe32aWBWhLrh~kZUPR3ATGp55og6luzDKuAjHKa8ylinPcdcCMveIq32sISpyd2GUur83VBgDVMpIRRyxDM8RUspZVGIp-tKc~aFNM2OkRPI3I0TWrC3kb5CNgSHelIIOX8bpGHKjqJ1rKtKV4kfmS~bQEFFdjlWQdelTS4v99D6zT5SXSXrRCJSdkiIixJkxFyElFLdstE681dPxsLLxvJPUytHMl6HlFylAHIRlmHi5l2B64SPRujPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma","translated_slug":"","page_count":20,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406968/thumbnails/1.jpg","file_name":"0165-5728_2886_2990064-020221117-1-sckxlx.pdf","download_url":"https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glioma_associated_antigens_defined_by_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406968/0165-5728_2886_2990064-020221117-1-sckxlx-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DGlioma_associated_antigens_defined_by_mo.pdf\u0026Expires=1732748557\u0026Signature=aahNnUZbOShyUbxKGLFGPsTMmKVnSGha4y9wgOfaFVA7GywFKh0kbui7pwnIdvp-xIPaV~bImPOFnZUNXNIr0uhw6xjvyCe32aWBWhLrh~kZUPR3ATGp55og6luzDKuAjHKa8ylinPcdcCMveIq32sISpyd2GUur83VBgDVMpIRRyxDM8RUspZVGIp-tKc~aFNM2OkRPI3I0TWrC3kb5CNgSHelIIOX8bpGHKjqJ1rKtKV4kfmS~bQEFFdjlWQdelTS4v99D6zT5SXSXrRCJSdkiIixJkxFyElFLdstE681dPxsLLxvJPUytHMl6HlFylAHIRlmHi5l2B64SPRujPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1159038,"name":"Epitopes","url":"https://www.academia.edu/Documents/in/Epitopes"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3398462,"name":"epitope","url":"https://www.academia.edu/Documents/in/epitope"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996404"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration"><img alt="Research paper thumbnail of Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration" class="work-thumbnail" src="https://attachments.academia-assets.com/94407036/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration">Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 1989</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="94a3e9edc40e856d19d7a49312e1b206" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94407036,"asset_id":90996404,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996404"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996404"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996404; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996404]").text(description); $(".js-view-count[data-work-id=90996404]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996404; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996404']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996404, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "94a3e9edc40e856d19d7a49312e1b206" } } $('.js-work-strip[data-work-id=90996404]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996404,"title":"Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Catecholamines, acting via the alpha-l adrenergic receptor, have been demonstrated to influence adult rat hepatocyte DNA synthesis in primary culture and in vivo during liver regeneration following partial hepatectomy (PHX). Earlier investigations have suggested that the alpha-1 effect on DNA synthesis is significant only during the first day following PHX. We examined receptor binding at several early and late time points after surgery, and we observed a significant loss of specific ['H]-prazosin binding to cells isolated from rat livers 48 and 72 hr after PHX. In contrast, the ability of norepinephrine to stimulate inositol phosphate production in isolated cells prelabeled with [3H]-myo-inositol was transiently reduced between 8 and 16 hr, when alpha-1 binding capacity was virtually unchanged. This uncoupling of phosphoinositide turnover from binding was preceded by a drop in hepatic membrane ras p21 content, as assayed by liquid competition radioimmunoassay. The loss of immunoreactive p21 from membranes was significant by 2 hr after PHX. These findings suggest a role for alpha-1 receptors and ras protein in the early events of liver regeneration.","publication_date":{"day":null,"month":null,"year":1989,"errors":{}},"publication_name":"Journal of Cellular Physiology","grobid_abstract_attachment_id":94407036},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration","translated_internal_url":"","created_at":"2022-11-17T06:36:50.407-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94407036,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407036/thumbnails/1.jpg","file_name":"jcp.104140020220221117-1-1va7vwm.pdf","download_url":"https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regulation_of_hepatocyte_growth_Alpha_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407036/jcp.104140020220221117-1-1va7vwm-libre.pdf?1668696083=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_hepatocyte_growth_Alpha_1.pdf\u0026Expires=1732748557\u0026Signature=A3AXeuQQboDekd~ck5AP~7pT9i~-tYt2egMT76v~IiRUSAxLmB9eVvCxmfC3byubCBjaVUY45dKWUMZNwrNl2gOUaEkN3NO66vpzGKAnsyEuqxE0yPTFpYtcK2ybWXWBvSsLq3wBWVIQHzc9A1kS5KRXB1Ig41tHkBtkkRIr0YanhaEVjV3ivX0rqFzGoV7PZP6U~ChaN~FMYHOtwSJP2tT-YHN4DTr3gcuy5~RIffazoyR0fK~h9LXHJSt9cg0NfqvdG9xk8OLCXUN6Xv2EfJTIesWYlDF91bB8IHOf85K1mX35HeBIOlte2cYegqnF1mFQy1hiA~jg5kCbUYW2lQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94407036,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407036/thumbnails/1.jpg","file_name":"jcp.104140020220221117-1-1va7vwm.pdf","download_url":"https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regulation_of_hepatocyte_growth_Alpha_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407036/jcp.104140020220221117-1-1va7vwm-libre.pdf?1668696083=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_hepatocyte_growth_Alpha_1.pdf\u0026Expires=1732748557\u0026Signature=A3AXeuQQboDekd~ck5AP~7pT9i~-tYt2egMT76v~IiRUSAxLmB9eVvCxmfC3byubCBjaVUY45dKWUMZNwrNl2gOUaEkN3NO66vpzGKAnsyEuqxE0yPTFpYtcK2ybWXWBvSsLq3wBWVIQHzc9A1kS5KRXB1Ig41tHkBtkkRIr0YanhaEVjV3ivX0rqFzGoV7PZP6U~ChaN~FMYHOtwSJP2tT-YHN4DTr3gcuy5~RIffazoyR0fK~h9LXHJSt9cg0NfqvdG9xk8OLCXUN6Xv2EfJTIesWYlDF91bB8IHOf85K1mX35HeBIOlte2cYegqnF1mFQy1hiA~jg5kCbUYW2lQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":168638,"name":"Inositol","url":"https://www.academia.edu/Documents/in/Inositol"},{"id":177688,"name":"Cellular Physiology","url":"https://www.academia.edu/Documents/in/Cellular_Physiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":404319,"name":"Liver regeneration","url":"https://www.academia.edu/Documents/in/Liver_regeneration"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"},{"id":664203,"name":"Hepatocyte","url":"https://www.academia.edu/Documents/in/Hepatocyte"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":2235833,"name":"Dna Synthesis","url":"https://www.academia.edu/Documents/in/Dna_Synthesis"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996396"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice"><img alt="Research paper thumbnail of The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice">The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice</a></div><div class="wp-workCard_item"><span>British Journal of Neurosurgery</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab&amp;#39;)2 fragments are required.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996396"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996396"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996396; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996396]").text(description); $(".js-view-count[data-work-id=90996396]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996396; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996396']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996396, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996396]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996396,"title":"The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice","translated_title":"","metadata":{"abstract":"ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab\u0026amp;#39;)2 fragments are required.","publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"British Journal of Neurosurgery"},"translated_abstract":"ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab\u0026amp;#39;)2 fragments are required.","internal_url":"https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice","translated_internal_url":"","created_at":"2022-11-17T06:36:43.780-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1686435,"name":"Monoclonal","url":"https://www.academia.edu/Documents/in/Monoclonal"}],"urls":[{"id":26082025,"url":"http://www.tandfonline.com/doi/pdf/10.3109/02688698808992668"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes"><img alt="Research paper thumbnail of Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes">Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996389; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996389]").text(description); $(".js-view-count[data-work-id=90996389]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996389; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996389']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996389, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996389]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996389,"title":"Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes","translated_title":"","metadata":{"abstract":"Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"British Journal of Haematology"},"translated_abstract":"Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.","internal_url":"https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes","translated_internal_url":"","created_at":"2022-11-17T06:36:38.021-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52136,"name":"Platelet","url":"https://www.academia.edu/Documents/in/Platelet"},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":138603,"name":"Thrombocytopenia","url":"https://www.academia.edu/Documents/in/Thrombocytopenia"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":1159037,"name":"Fusion Protein","url":"https://www.academia.edu/Documents/in/Fusion_Protein"},{"id":1281375,"name":"Hematocrit","url":"https://www.academia.edu/Documents/in/Hematocrit"},{"id":1281380,"name":"Platelet Count","url":"https://www.academia.edu/Documents/in/Platelet_Count"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":3360152,"name":"Absolute Neutrophil Count","url":"https://www.academia.edu/Documents/in/Absolute_Neutrophil_Count"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":26082022,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.1998.01012.x"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996384"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity"><img alt="Research paper thumbnail of New Cytokines with Thrombopoietic Activity" class="work-thumbnail" src="https://attachments.academia-assets.com/94406941/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity">New Cytokines with Thrombopoietic Activity</a></div><div class="wp-workCard_item"><span>Clinical Immunotherapeutics</span><span>, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f1459a517fd7b26c669e51d0f8a234ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406941,"asset_id":90996384,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996384"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996384"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996384; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996384]").text(description); $(".js-view-count[data-work-id=90996384]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996384; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996384']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996384, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f1459a517fd7b26c669e51d0f8a234ea" } } $('.js-work-strip[data-work-id=90996384]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996384,"title":"New Cytokines with Thrombopoietic Activity","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Clinical Immunotherapeutics"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity","translated_internal_url":"","created_at":"2022-11-17T06:36:33.458-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406941/thumbnails/1.jpg","file_name":"BF0325926020221117-1-2ygvgv.pdf","download_url":"https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_Cytokines_with_Thrombopoietic_Activi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406941/BF0325926020221117-1-2ygvgv-libre.pdf?1668696104=\u0026response-content-disposition=attachment%3B+filename%3DNew_Cytokines_with_Thrombopoietic_Activi.pdf\u0026Expires=1732748557\u0026Signature=bdr6QglPcV8uoCcZThnlw~p27RvBlBE~Mot4a24NnvT1RFYtn8aigYyEYU6mVMPH8NYQDojsFDsIxCtq9HZdj1I~NROxFnp7tNVkTU9a76ij5q-Q7IOWoLKg2K3IXgGS-aN19Of26QM~m18AX0nefnpesyMPFrh0Tv8pdeREU67~btVHBP0xBw2U-qfqM0YjxOmuoO22l-Nh2~67TFg2hJ52cDPXGMcXorpz~GGyRH~UeUIe4AzGEuu~fbqHKeqm3Ev37KKPr~unnl97fmg8hGM98~vV9nvcoPjMMpG~ck1XXtCQou5RsfhTOCDlaI4e3RndR6cS87zQCifOIyGoig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"New_Cytokines_with_Thrombopoietic_Activity","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406941/thumbnails/1.jpg","file_name":"BF0325926020221117-1-2ygvgv.pdf","download_url":"https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_Cytokines_with_Thrombopoietic_Activi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406941/BF0325926020221117-1-2ygvgv-libre.pdf?1668696104=\u0026response-content-disposition=attachment%3B+filename%3DNew_Cytokines_with_Thrombopoietic_Activi.pdf\u0026Expires=1732748557\u0026Signature=bdr6QglPcV8uoCcZThnlw~p27RvBlBE~Mot4a24NnvT1RFYtn8aigYyEYU6mVMPH8NYQDojsFDsIxCtq9HZdj1I~NROxFnp7tNVkTU9a76ij5q-Q7IOWoLKg2K3IXgGS-aN19Of26QM~m18AX0nefnpesyMPFrh0Tv8pdeREU67~btVHBP0xBw2U-qfqM0YjxOmuoO22l-Nh2~67TFg2hJ52cDPXGMcXorpz~GGyRH~UeUIe4AzGEuu~fbqHKeqm3Ev37KKPr~unnl97fmg8hGM98~vV9nvcoPjMMpG~ck1XXtCQou5RsfhTOCDlaI4e3RndR6cS87zQCifOIyGoig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":204384,"name":"Haematopoiesis","url":"https://www.academia.edu/Documents/in/Haematopoiesis"},{"id":295233,"name":"Cytokine","url":"https://www.academia.edu/Documents/in/Cytokine"},{"id":3670392,"name":"Thrombopoiesis","url":"https://www.academia.edu/Documents/in/Thrombopoiesis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":26082020,"url":"http://link.springer.com/content/pdf/10.1007/BF03259260.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996381"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts"><img alt="Research paper thumbnail of Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts" class="work-thumbnail" src="https://attachments.academia-assets.com/94406939/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts">Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts</a></div><div class="wp-workCard_item"><span>Biochemical Pharmacology</span><span>, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2c6f8ba93a56f7adbb8c044f1e97804" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406939,"asset_id":90996381,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996381"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996381"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996381; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996381]").text(description); $(".js-view-count[data-work-id=90996381]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996381; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996381']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996381, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d2c6f8ba93a56f7adbb8c044f1e97804" } } $('.js-work-strip[data-work-id=90996381]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996381,"title":"Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Biochemical Pharmacology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts","translated_internal_url":"","created_at":"2022-11-17T06:36:30.893-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406939,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406939/thumbnails/1.jpg","file_name":"0006-2952_2888_2990612-020221117-1-11s12e7.pdf","download_url":"https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Buthionine_sulfoximine_mediated_depletio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406939/0006-2952_2888_2990612-020221117-1-11s12e7-libre.pdf?1668696097=\u0026response-content-disposition=attachment%3B+filename%3DButhionine_sulfoximine_mediated_depletio.pdf\u0026Expires=1732748557\u0026Signature=YBpLhQKo5KzAmBafujgmyufGIyxoZAMOS3~EiB8EedjQ5PX3-qXFQ0y02664p5KfJtE2YOzR-TO2CNRRrPJstBcIRaJAJGbBoV1dJQLRwckEDY1wFBxBJ6Lgmm7KkmqCDlpq5c8npcVbdccjsjGWdNY7miNxAaCqVn0jTCXBtuce7F-pKAY71o0Bc7S9HjQtUHD4SiX-43aRlZfA2B-WIE87DUIlYAK8ZX4EXUXmVHnWXNqrc4hS3GaZuadyaTsGyqmMNAlLh9oYsz0l1NVK~nD9C642HLYRz1mm9DIFwzhbjPYwWe5nQzGIpEhNrjXqpSYRjt6XyQnfIUb-4TuAIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406939,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406939/thumbnails/1.jpg","file_name":"0006-2952_2888_2990612-020221117-1-11s12e7.pdf","download_url":"https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Buthionine_sulfoximine_mediated_depletio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406939/0006-2952_2888_2990612-020221117-1-11s12e7-libre.pdf?1668696097=\u0026response-content-disposition=attachment%3B+filename%3DButhionine_sulfoximine_mediated_depletio.pdf\u0026Expires=1732748557\u0026Signature=YBpLhQKo5KzAmBafujgmyufGIyxoZAMOS3~EiB8EedjQ5PX3-qXFQ0y02664p5KfJtE2YOzR-TO2CNRRrPJstBcIRaJAJGbBoV1dJQLRwckEDY1wFBxBJ6Lgmm7KkmqCDlpq5c8npcVbdccjsjGWdNY7miNxAaCqVn0jTCXBtuce7F-pKAY71o0Bc7S9HjQtUHD4SiX-43aRlZfA2B-WIE87DUIlYAK8ZX4EXUXmVHnWXNqrc4hS3GaZuadyaTsGyqmMNAlLh9oYsz0l1NVK~nD9C642HLYRz1mm9DIFwzhbjPYwWe5nQzGIpEhNrjXqpSYRjt6XyQnfIUb-4TuAIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":648326,"name":"BIOCHEMICAL PHARMACOLOGY","url":"https://www.academia.edu/Documents/in/BIOCHEMICAL_PHARMACOLOGY"},{"id":1014097,"name":"Methionine Sulfoximine","url":"https://www.academia.edu/Documents/in/Methionine_Sulfoximine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE"><img alt="Research paper thumbnail of 25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE">25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE</a></div><div class="wp-workCard_item"><span>Journal of Neuropathology and Experimental Neurology</span><span>, 1984</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996115]").text(description); $(".js-view-count[data-work-id=90996115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996115, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996115,"title":"25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":1984,"errors":{}},"publication_name":"Journal of Neuropathology and Experimental Neurology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE","translated_internal_url":"","created_at":"2022-11-17T06:34:09.719-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":118793,"name":"Sarcoma","url":"https://www.academia.edu/Documents/in/Sarcoma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="16407309" id="papers"><div class="js-work-strip profile--work_container" data-work-id="121154712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects"><img alt="Research paper thumbnail of Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects">Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects</a></div><div class="wp-workCard_item"><span>Allergy and immunology</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154712]").text(description); $(".js-view-count[data-work-id=121154712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154712, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121154712]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154712,"title":"Late Breaking Abstract - Effect of MMP-12 inhibitor, Adermastat-(FP-025), on allergen-induced late response in asthmatic subjects","translated_title":"","metadata":{"publisher":"European Respiratory Society","publication_name":"Allergy and immunology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/121154712/Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects","translated_internal_url":"","created_at":"2024-06-17T16:18:11.723-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Late_Breaking_Abstract_Effect_of_MMP_12_inhibitor_Adermastat_FP_025_on_allergen_induced_late_response_in_asthmatic_subjects","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology"}],"urls":[{"id":43021062,"url":"https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2023.OA2494"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121154711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies"><img alt="Research paper thumbnail of Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies">Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, Dec 1, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154711]").text(description); $(".js-view-count[data-work-id=121154711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154711, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121154711]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154711,"title":"Partial purification and characterization of a murine glioma-associated antigen defined by syngeneic rat monoclonal antibodies","translated_title":"","metadata":{"abstract":"A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.","publisher":"Elsevier BV","publication_date":{"day":1,"month":12,"year":1986,"errors":{}},"publication_name":"Journal of Neuroimmunology"},"translated_abstract":"A glioma-associated antigen was previously identified on an avian sarcoma virus-induced F-344 rat astrocytoma cell line S69-c15 by four rat monoclonal antibodies (7G4, 9F1, 10E3 and 10E7) produced after syngeneic immunization. Earlier data suggested all four antibodies reacted with a polypeptide-associated epitope. We report here that the antigen activity was detected in the supernatant of tumor homogenates and could pass through a 1000 Da molecular weight cut-off dialysis membrane, as determined by antibody binding inhibition in a cell surface radioimmunoassay. When the dialysate was fractionated by Bio-Gel P-2 chromatography, antibody inhibiting activity eluted in the range of 300-600 Da. A highly purified material was further isolated by ion exchange high pressure liquid chromatography. Parallel purification product from an antigen-negative cell line failed to demonstrate antibody inhibiting activity. We conclude that greater than 400-fold purification enrichment of antigen can be achieved. We postulate that the partially purified antigenic determinant is a glioma-associated determinant of highly restricted expression and is presented in hapten-carrier form by the glioma cells.","internal_url":"https://www.academia.edu/121154711/Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies","translated_internal_url":"","created_at":"2024-06-17T16:18:11.527-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Partial_purification_and_characterization_of_a_murine_glioma_associated_antigen_defined_by_syngeneic_rat_monoclonal_antibodies","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3398462,"name":"epitope","url":"https://www.academia.edu/Documents/in/epitope"}],"urls":[{"id":43021061,"url":"https://doi.org/10.1016/0165-5728(86)90065-2"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121154710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects"><img alt="Research paper thumbnail of First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects" class="work-thumbnail" src="https://attachments.academia-assets.com/116110832/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects">First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects</a></div><div class="wp-workCard_item"><span>Clinical Drug Investigation</span><span>, Dec 17, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c692546bc93031df4ed7e19ed06de377" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116110832,"asset_id":121154710,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121154710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121154710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121154710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121154710]").text(description); $(".js-view-count[data-work-id=121154710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121154710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121154710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121154710, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c692546bc93031df4ed7e19ed06de377" } } $('.js-work-strip[data-work-id=121154710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121154710,"title":"First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects","translated_title":"","metadata":{"publisher":"Adis, Springer Healthcare","grobid_abstract":"Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.","publication_date":{"day":17,"month":12,"year":2020,"errors":{}},"publication_name":"Clinical Drug Investigation","grobid_abstract_attachment_id":116110832},"translated_abstract":null,"internal_url":"https://www.academia.edu/121154710/First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects","translated_internal_url":"","created_at":"2024-06-17T16:18:11.290-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116110832,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110832/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110832/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=Vl~W6k0lg4mjKDrd~CXdYcNew41MeUnp52~yzhBrJL8CkCP2XdZTUtWQoU-ed2Uuln0Lj-bKss8~4oZ74REE8mu1naIrxZ4Zcb7VrST3zprtL81dlTKc4ZRGMKqHerFoedj-EhTN0rCGvzPtWvBSXPmwgxKd7wOjiuqus0s6S0clztK129DthU7quqgMA5bWpA1tt9cgnaUKDWNwxtOcETDEK9ISK2-JteD62Hbp21eVj5GE1DPdoSZWOnIeZDybARehQJzXMzpRRLRFWnE~Uhug~xLAgAZ4WmNg7jny0f04wupzqR4aOcGKJjPLRtdt7DcP9Pq08DK3djPgnrc57w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"First_in_Man_Safety_Tolerability_and_Pharmacokinetics_of_a_Novel_and_Highly_Selective_Inhibitor_of_Matrix_Metalloproteinase_12_FP_025_Results_from_Two_Randomized_Studies_in_Healthy_Subjects","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":116110832,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110832/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110832/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110832/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=Vl~W6k0lg4mjKDrd~CXdYcNew41MeUnp52~yzhBrJL8CkCP2XdZTUtWQoU-ed2Uuln0Lj-bKss8~4oZ74REE8mu1naIrxZ4Zcb7VrST3zprtL81dlTKc4ZRGMKqHerFoedj-EhTN0rCGvzPtWvBSXPmwgxKd7wOjiuqus0s6S0clztK129DthU7quqgMA5bWpA1tt9cgnaUKDWNwxtOcETDEK9ISK2-JteD62Hbp21eVj5GE1DPdoSZWOnIeZDybARehQJzXMzpRRLRFWnE~Uhug~xLAgAZ4WmNg7jny0f04wupzqR4aOcGKJjPLRtdt7DcP9Pq08DK3djPgnrc57w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116110833,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116110833/thumbnails/1.jpg","file_name":"s40261_020_00981_9.pdf","download_url":"https://www.academia.edu/attachments/116110833/download_file","bulk_download_file_name":"First_in_Man_Safety_Tolerability_and_Pha.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116110833/s40261_020_00981_9-libre.pdf?1718673718=\u0026response-content-disposition=attachment%3B+filename%3DFirst_in_Man_Safety_Tolerability_and_Pha.pdf\u0026Expires=1732748557\u0026Signature=G2pBat0W5-0fuk~IYHw2MduiX3-iE8zcmkNBpYkPOzsRReM99AvJ9JvkpPYDt-~1ycJy1zRpJAqOzJf6EvBwdrtxDDX2P7ox8iCivocvT75nenbBwpogfLFk91oaUZC40RfayBXhZOoaPPu~GBT-07X46KI4OQCav0HrFq7sTkknnKQ36dfye7i7B5yHp4RqfxuuoLkN9Fl6CAHU2V5AljtHXogbqFRB5tRrgBKyR5wE-c2x8lOOVI-FdUU65P~cBKhCmrxs1EUOnh8rc54hzCanvw2e0EvdCNxd5r-PyquuOrtqfm7ZwB1D9bHKMSg3foBqhvKDIqytwGbRAg1VvA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":11111,"name":"Pharmacokinetics","url":"https://www.academia.edu/Documents/in/Pharmacokinetics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":89956,"name":"Pharmaceutical Sciences","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Sciences"},{"id":612887,"name":"Capsule","url":"https://www.academia.edu/Documents/in/Capsule"},{"id":2601211,"name":"Adverse effect","url":"https://www.academia.edu/Documents/in/Adverse_effect"},{"id":2641150,"name":"Tolerability","url":"https://www.academia.edu/Documents/in/Tolerability"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":43021060,"url":"https://pure.rug.nl/ws/files/632784246/s40261_020_00981_9.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996464"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology"><img alt="Research paper thumbnail of The Applications of Monoclonal Antibodies in Neuro-Oncology" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology">The Applications of Monoclonal Antibodies in Neuro-Oncology</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. M...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996464"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996464"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996464; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996464]").text(description); $(".js-view-count[data-work-id=90996464]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996464; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996464']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996464, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996464]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996464,"title":"The Applications of Monoclonal Antibodies in Neuro-Oncology","translated_title":"","metadata":{"abstract":"Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.","publication_date":{"day":null,"month":null,"year":1987,"errors":{}}},"translated_abstract":"Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis despite surgery and combined radiation and chemotherapy (1, 2). Immunological approaches to diagnosis and treatment have seemed attractive, but in the past have been frustrated by technological limitations (3, 4). Monoclonal antibody methodology offers major advantages over conventional methods of antiserum production: a practically unlimited source of homogeneous, highly specific reagent which may be prepared using impure or complex antigens. This has led to a new age in neuroimmunology and neuro-oncology, with the potential for better understanding of the basic cell biology of CNS neoplasia, and for improvement in diagnosis, imaging, and therapy.","internal_url":"https://www.academia.edu/90996464/The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology","translated_internal_url":"","created_at":"2022-11-17T06:37:32.142-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Applications_of_Monoclonal_Antibodies_in_Neuro_Oncology","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996455"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients"><img alt="Research paper thumbnail of A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients" class="work-thumbnail" src="https://attachments.academia-assets.com/94406936/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients">A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients</a></div><div class="wp-workCard_item"><span>World Journal of Urology</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="135ddbd546037bdd2a95dc872d2c613d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406936,"asset_id":90996455,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996455"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996455"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996455; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996455]").text(description); $(".js-view-count[data-work-id=90996455]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996455; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996455']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996455, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "135ddbd546037bdd2a95dc872d2c613d" } } $('.js-work-strip[data-work-id=90996455]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996455,"title":"A phase 3, open-label, multicenter study of a 6-month pre-mixed depot formulation of leuprolide mesylate in advanced prostate cancer patients","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Objectives To determine the safety, efficacy and pharmacokinetic (PK) profile of a pre-mixed depot formulation of leuprolide mesylate subcutaneous injectable suspension (LMIS) 50 mg for up to 1 year of treatment for subjects with advanced prostate cancer. Patients and methods In this open-label, multicenter study, prostate cancer patients with indication for androgen ablation therapy received two subcutaneous injection of LMIS 50 mg 6 months apart and were followed for an additional 6 months. Two efficacy primary end points were the percentage of subjects with a serum testosterone level ≤ 50 ng/dL by Day 28 as well as the percentage of subjects with similar testosterone suppression from Day 28 to Day 336. Results Of the 137 enrolled subjects, 15 (10.9%) subjects did not complete the study, including 5 subjects who terminated early due to an adverse event. By Day 28, 98.5% (95% confidence interval 94.8-99.8) of the subjects achieved a castrate testosterone level. At the end of the study, 97% and 95.9% of the subjects had serum testosterone level ≤ 50 ng/dL and ≤ 20 ng/ dL, respectively. LMIS 50 mg significantly reduced serum prostate-specific antigen levels after its first injection and this PSA declination effect remained until the end of the study. No statistically significant change was observed in worsening bone pain or urinary symptom assessments during the study. Hot flush (48.9%) and hypertension (14.6%) were the two most common adverse events reported. Conclusions LMIS 50 mg, administered at 6-month intervals, effectively suppressed serum testosterone level, and demonstrated a consistent safety profile.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"World Journal of Urology","grobid_abstract_attachment_id":94406936},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996455/A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients","translated_internal_url":"","created_at":"2022-11-17T06:37:26.018-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406936/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406936/s00345-019-02741-7-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=ElWae4lUYuwFPOo8LLIbpi0IG3yyBMIyJhsqezZZJswoV8wVJ-E9IcwzPT23YqA66gDOwu0cE6BJrEsagsibo8tiibtX3QHovb~EWRpPwdXJymi4NFSTHM3IFSsV5EFwcutksNJfMIwreZpHUDRJLZ3wU4FdAeGxgPchZ-VG2HBUBNavLIUP6JE7CmesEpJHWHm9J5ne1fhJCNCPfc681CMMIiqEcvs0OvbNh0353YDII5nwmj0~7YCyoBim1hDzefl3QrSTXI7PlVhxYr6uUs3dWjbgRuJ~hhrq59bB3xNsd43Wj8CszAk80GnSCHyM324DC2JFf04Isr6uM0pfwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_phase_3_open_label_multicenter_study_of_a_6_month_pre_mixed_depot_formulation_of_leuprolide_mesylate_in_advanced_prostate_cancer_patients","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406936,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406936/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406936/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406936/s00345-019-02741-7-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=ElWae4lUYuwFPOo8LLIbpi0IG3yyBMIyJhsqezZZJswoV8wVJ-E9IcwzPT23YqA66gDOwu0cE6BJrEsagsibo8tiibtX3QHovb~EWRpPwdXJymi4NFSTHM3IFSsV5EFwcutksNJfMIwreZpHUDRJLZ3wU4FdAeGxgPchZ-VG2HBUBNavLIUP6JE7CmesEpJHWHm9J5ne1fhJCNCPfc681CMMIiqEcvs0OvbNh0353YDII5nwmj0~7YCyoBim1hDzefl3QrSTXI7PlVhxYr6uUs3dWjbgRuJ~hhrq59bB3xNsd43Wj8CszAk80GnSCHyM324DC2JFf04Isr6uM0pfwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":94406937,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406937/thumbnails/1.jpg","file_name":"s00345-019-02741-7.pdf","download_url":"https://www.academia.edu/attachments/94406937/download_file","bulk_download_file_name":"A_phase_3_open_label_multicenter_study_o.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406937/s00345-019-02741-7-libre.pdf?1668696091=\u0026response-content-disposition=attachment%3B+filename%3DA_phase_3_open_label_multicenter_study_o.pdf\u0026Expires=1732748557\u0026Signature=OhQic3y~QiJA-N7fyibHli~V~vqeCS088pwhOqmJXEBI09loN-YKjv~wqhCdXTCRI46EgAgB0WV4ACIcj6-GcXo~OFqnf67aKhcM3mHzowrg2R5acfJG0jQd991~F1jWM~PgJiyltSx3XtdfiEjBtweCnikasgNP-v3Drn73ES3VUHXM~-XCYFa1NLtbodLdNcP6S-2V6f~PvG9g3DwZRnoIF0UK2GRU1I--xIYDOiaGkuqOrYQYfL~xKNpW6J2AjX~oXFXSbTrYAgxB9YOgSQ~ocW1kWiZn~Q4aSC~DhQPsDqzts11X7pGA1DuFeiNpMx18c02ZlOue2VtF3ww9Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[{"id":26082049,"url":"http://link.springer.com/content/pdf/10.1007/s00345-019-02741-7.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996442"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas"><img alt="Research paper thumbnail of Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas" class="work-thumbnail" src="https://attachments.academia-assets.com/94406996/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas">Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas</a></div><div class="wp-workCard_item"><span>Neurologic Clinics</span><span>, 1985</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0519dda9f32550cb2ba6ca1052252d3f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406996,"asset_id":90996442,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996442"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996442"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996442; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996442]").text(description); $(".js-view-count[data-work-id=90996442]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996442; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996442']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996442, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0519dda9f32550cb2ba6ca1052252d3f" } } $('.js-work-strip[data-work-id=90996442]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996442,"title":"Aspects of Immunobiology and Immunotherapy and Uses of Monoclonal Antibodies and Biologic Immune Modifiers in Human Gliomas","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Neurologic Clinics"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996442/Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas","translated_internal_url":"","created_at":"2022-11-17T06:37:20.612-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406996,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406996/thumbnails/1.jpg","file_name":"s0733-8619_2818_2931221-020221117-1-1x6akdf.pdf","download_url":"https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Aspects_of_Immunobiology_and_Immunothera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406996/s0733-8619_2818_2931221-020221117-1-1x6akdf-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DAspects_of_Immunobiology_and_Immunothera.pdf\u0026Expires=1732748557\u0026Signature=I0wHUWfGac3WT8wajhL9z5-v9O8ZK6xU4ZpuHeIj9aQRCuu-BNM4yuXn3eiJac41JzI2UZqJC-99XOKb0YGJ0oSoEEHvRAR7yniJ2GzBHv~Hkfr4cyn2EnTp6YFvuH5XIyQlltYzRdwxewxT7xDvEmZmFNmlomMBl-4dQAxPqnB46zzbhSmLXVEBJDBaM7eOss7Oiif7yiKgiW43gks~nILd1awTcqVZnTA5RETQ~KSxqK7YIZmcrwZkFZfUI-vGHPyOBolObibm1DqTkmt87WKD2r6esuU9HSa3swqvQQbKkfBn2~iujimRKfpc5aIM~Fka3OcL670mOiEmciv1aQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Aspects_of_Immunobiology_and_Immunotherapy_and_Uses_of_Monoclonal_Antibodies_and_Biologic_Immune_Modifiers_in_Human_Gliomas","translated_slug":"","page_count":17,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406996,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406996/thumbnails/1.jpg","file_name":"s0733-8619_2818_2931221-020221117-1-1x6akdf.pdf","download_url":"https://www.academia.edu/attachments/94406996/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Aspects_of_Immunobiology_and_Immunothera.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406996/s0733-8619_2818_2931221-020221117-1-1x6akdf-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DAspects_of_Immunobiology_and_Immunothera.pdf\u0026Expires=1732748557\u0026Signature=I0wHUWfGac3WT8wajhL9z5-v9O8ZK6xU4ZpuHeIj9aQRCuu-BNM4yuXn3eiJac41JzI2UZqJC-99XOKb0YGJ0oSoEEHvRAR7yniJ2GzBHv~Hkfr4cyn2EnTp6YFvuH5XIyQlltYzRdwxewxT7xDvEmZmFNmlomMBl-4dQAxPqnB46zzbhSmLXVEBJDBaM7eOss7Oiif7yiKgiW43gks~nILd1awTcqVZnTA5RETQ~KSxqK7YIZmcrwZkFZfUI-vGHPyOBolObibm1DqTkmt87WKD2r6esuU9HSa3swqvQQbKkfBn2~iujimRKfpc5aIM~Fka3OcL670mOiEmciv1aQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":485569,"name":"Glial Fibrillary Acidic Protein","url":"https://www.academia.edu/Documents/in/Glial_Fibrillary_Acidic_Protein"},{"id":637718,"name":"Nervous System","url":"https://www.academia.edu/Documents/in/Nervous_System"},{"id":868560,"name":"Lymphocytes","url":"https://www.academia.edu/Documents/in/Lymphocytes"},{"id":894787,"name":"Immune Tolerance","url":"https://www.academia.edu/Documents/in/Immune_Tolerance"},{"id":1159038,"name":"Epitopes","url":"https://www.academia.edu/Documents/in/Epitopes"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1274458,"name":"Antigens","url":"https://www.academia.edu/Documents/in/Antigens"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[{"id":26082044,"url":"https://api.elsevier.com/content/article/PII:S0733861918312210?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996435"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration"><img alt="Research paper thumbnail of Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration" class="work-thumbnail" src="https://attachments.academia-assets.com/94406988/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration">Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="41ba888e4232af22b388f0a9bf2de0c6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406988,"asset_id":90996435,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996435"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996435"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996435; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996435]").text(description); $(".js-view-count[data-work-id=90996435]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996435; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996435']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996435, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "41ba888e4232af22b388f0a9bf2de0c6" } } $('.js-work-strip[data-work-id=90996435]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996435,"title":"Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration","translated_title":"","metadata":{"abstract":"Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","internal_url":"https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration","translated_internal_url":"","created_at":"2022-11-17T06:37:16.893-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406988,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406988/thumbnails/1.jpg","file_name":"1941.full.pdf","download_url":"https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_of_monoclonal_antibody_delive.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406988/1941.full-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DComparison_of_monoclonal_antibody_delive.pdf\u0026Expires=1732748557\u0026Signature=D1L1IUe04R-mOKES60fEranMTNZ7sZnCZdOr0PSHps2vipplyCSijq4o5UZeFdNWETOr4jzS~UFga~e2B71eTBEraXxgXow-kTJbhCcDG8aXvRTHxDAIxRDvo8i1DXwEQyJYWINNNuAN54KiGhak99BGI7lEKh~SKFifyti5DtmVErZFe2o2D7F5bODuR6xnM04ZxAGoNm-iGlr5UfjCMQDFw1I~X0NI9pus30nmz2Nz4wxfvJwT7ANXwQrTxkcFRnQcJClKOgp4mlFSL6D3cnLeLJ8jUCBR5MmKp9gF3b7cr1nirTz2zc49hiAkLF8fJ6yMxoFuX-0lTp0REg44BA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406988,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406988/thumbnails/1.jpg","file_name":"1941.full.pdf","download_url":"https://www.academia.edu/attachments/94406988/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_of_monoclonal_antibody_delive.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406988/1941.full-libre.pdf?1668696087=\u0026response-content-disposition=attachment%3B+filename%3DComparison_of_monoclonal_antibody_delive.pdf\u0026Expires=1732748557\u0026Signature=D1L1IUe04R-mOKES60fEranMTNZ7sZnCZdOr0PSHps2vipplyCSijq4o5UZeFdNWETOr4jzS~UFga~e2B71eTBEraXxgXow-kTJbhCcDG8aXvRTHxDAIxRDvo8i1DXwEQyJYWINNNuAN54KiGhak99BGI7lEKh~SKFifyti5DtmVErZFe2o2D7F5bODuR6xnM04ZxAGoNm-iGlr5UfjCMQDFw1I~X0NI9pus30nmz2Nz4wxfvJwT7ANXwQrTxkcFRnQcJClKOgp4mlFSL6D3cnLeLJ8jUCBR5MmKp9gF3b7cr1nirTz2zc49hiAkLF8fJ6yMxoFuX-0lTp0REg44BA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":249714,"name":"Biodistribution","url":"https://www.academia.edu/Documents/in/Biodistribution"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":967378,"name":"Radioisotopes","url":"https://www.academia.edu/Documents/in/Radioisotopes"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996428"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6"><img alt="Research paper thumbnail of Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6" class="work-thumbnail" src="https://attachments.academia-assets.com/94406986/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6">Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, Jan 15, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. T...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3459763f19404861aafd451d9c53c79f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406986,"asset_id":90996428,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996428"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996428"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996428; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996428]").text(description); $(".js-view-count[data-work-id=90996428]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996428; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996428']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996428, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3459763f19404861aafd451d9c53c79f" } } $('.js-work-strip[data-work-id=90996428]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996428,"title":"Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6","translated_title":"","metadata":{"abstract":"Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...","publication_date":{"day":15,"month":1,"year":1988,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...","internal_url":"https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6","translated_internal_url":"","created_at":"2022-11-17T06:37:13.088-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406986,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406986/thumbnails/1.jpg","file_name":"2904.full.pdf","download_url":"https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_intracranial_human_glioma_x.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406986/2904.full-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_intracranial_human_glioma_x.pdf\u0026Expires=1732748557\u0026Signature=DYCdMPyxz~g0Tg8WHj~Hu6a5aHW06cBHEfOHvY6c~ZTAQbtCEhGJkSroqzYog9rG2KpFAGzLbpcycBvQt3IKOTr2DBK7SmqTqpADaKoeB7AWifbAhSFY5aD2oCMr8SONH27O0ZM6oUs03JHmOAeQ1WXJfqtqFH0Yoz1gP39DCKPBUp0cjBrmO8NJ4FQIvEvWeuousGJv1Z4r8Mu8JUcCcIH9vaILwQn~v0B8IR8EDj9f8O4Opzurt0GYllExFhqF1zAk1pi314aaqsFd-8fHiREsWneK0lr87e9WvqjeJeJLMSYFk15MvVANtHaCE9e-PofXsCLdIwoNykKhl7pj-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406986,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406986/thumbnails/1.jpg","file_name":"2904.full.pdf","download_url":"https://www.academia.edu/attachments/94406986/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Treatment_of_intracranial_human_glioma_x.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406986/2904.full-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DTreatment_of_intracranial_human_glioma_x.pdf\u0026Expires=1732748557\u0026Signature=DYCdMPyxz~g0Tg8WHj~Hu6a5aHW06cBHEfOHvY6c~ZTAQbtCEhGJkSroqzYog9rG2KpFAGzLbpcycBvQt3IKOTr2DBK7SmqTqpADaKoeB7AWifbAhSFY5aD2oCMr8SONH27O0ZM6oUs03JHmOAeQ1WXJfqtqFH0Yoz1gP39DCKPBUp0cjBrmO8NJ4FQIvEvWeuousGJv1Z4r8Mu8JUcCcIH9vaILwQn~v0B8IR8EDj9f8O4Opzurt0GYllExFhqF1zAk1pi314aaqsFd-8fHiREsWneK0lr87e9WvqjeJeJLMSYFk15MvVANtHaCE9e-PofXsCLdIwoNykKhl7pj-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":74479,"name":"Isotype","url":"https://www.academia.edu/Documents/in/Isotype"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":2921967,"name":"Tenascin","url":"https://www.academia.edu/Documents/in/Tenascin"},{"id":2950651,"name":"Tissue distribution","url":"https://www.academia.edu/Documents/in/Tissue_distribution"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996422"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model"><img alt="Research paper thumbnail of Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model" class="work-thumbnail" src="https://attachments.academia-assets.com/94407015/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model">Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model</a></div><div class="wp-workCard_item"><span>Cancer research</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The development of Mabs, particularly those reactive with primary brain tumors but not with norma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1dfcbbe29fb10d439e9f64763a99731d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94407015,"asset_id":90996422,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996422"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996422"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996422; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996422]").text(description); $(".js-view-count[data-work-id=90996422]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996422; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996422']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996422, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1dfcbbe29fb10d439e9f64763a99731d" } } $('.js-work-strip[data-work-id=90996422]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996422,"title":"Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model","translated_title":"","metadata":{"abstract":"The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Cancer research"},"translated_abstract":"The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...","internal_url":"https://www.academia.edu/90996422/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model","translated_internal_url":"","created_at":"2022-11-17T06:37:09.043-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94407015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407015/thumbnails/1.jpg","file_name":"559.full.pdf","download_url":"https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_efficacy_of_antiglioma_mesen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407015/559.full-libre.pdf?1668696086=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_efficacy_of_antiglioma_mesen.pdf\u0026Expires=1732748557\u0026Signature=L-QPTxmjM9dnOgOVaLKjAb4bLM5uauXl1lJB3aAWWMRERB~5QHXPPdlM4LzuQ18sz4ZNZ-BxRMFQ02Hd-l4DsbQju8eaXYEhKLfafJN2bVhhXr3zaZ~b6MNZDGJcvU1sq-ZvRb4-~TIVaweQr1lXoD~sBDIZlZQs52JCx5NQqeM4ov~gpdfX8NgpxAMSFmAi2C7W1UyglZIoSrOrOZYm04ii817ehnk3SkZgshgjDo24IDRvH5tBtCLMSBSp~IwSlcP1aO4RouSJYRYxNC6jFGRyw7AFFMjguh2~51th8RprLxVoogGpF04AUWBOnIcxFjPFcktpcnYJuupsulaXAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94407015,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407015/thumbnails/1.jpg","file_name":"559.full.pdf","download_url":"https://www.academia.edu/attachments/94407015/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Therapeutic_efficacy_of_antiglioma_mesen.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407015/559.full-libre.pdf?1668696086=\u0026response-content-disposition=attachment%3B+filename%3DTherapeutic_efficacy_of_antiglioma_mesen.pdf\u0026Expires=1732748557\u0026Signature=L-QPTxmjM9dnOgOVaLKjAb4bLM5uauXl1lJB3aAWWMRERB~5QHXPPdlM4LzuQ18sz4ZNZ-BxRMFQ02Hd-l4DsbQju8eaXYEhKLfafJN2bVhhXr3zaZ~b6MNZDGJcvU1sq-ZvRb4-~TIVaweQr1lXoD~sBDIZlZQs52JCx5NQqeM4ov~gpdfX8NgpxAMSFmAi2C7W1UyglZIoSrOrOZYm04ii817ehnk3SkZgshgjDo24IDRvH5tBtCLMSBSp~IwSlcP1aO4RouSJYRYxNC6jFGRyw7AFFMjguh2~51th8RprLxVoogGpF04AUWBOnIcxFjPFcktpcnYJuupsulaXAQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":51883,"name":"Brain Tumor","url":"https://www.academia.edu/Documents/in/Brain_Tumor"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":151951,"name":"Animal Model","url":"https://www.academia.edu/Documents/in/Animal_Model"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins"},{"id":389506,"name":"Radiation Dose","url":"https://www.academia.edu/Documents/in/Radiation_Dose"},{"id":399886,"name":"Specific Activity","url":"https://www.academia.edu/Documents/in/Specific_Activity"},{"id":573989,"name":"Malignant Glioma","url":"https://www.academia.edu/Documents/in/Malignant_Glioma"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1426712,"name":"Immunoglobulin","url":"https://www.academia.edu/Documents/in/Immunoglobulin"},{"id":1662977,"name":"Nude mice","url":"https://www.academia.edu/Documents/in/Nude_mice"},{"id":1817281,"name":"Extracellular Matrix Proteins","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix_Proteins"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996417"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma"><img alt="Research paper thumbnail of A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma">A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma</a></div><div class="wp-workCard_item"><span>Journal of Neuropathology and Experimental Neurology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996417"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996417"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996417; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996417]").text(description); $(".js-view-count[data-work-id=90996417]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996417; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996417']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996417, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996417]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996417,"title":"A Glial Fibrillary Acidic Protein-Expressing and Tumorigenic Cell Line Derived from an Avian Sarcoma Virus-Induced Rat Astrocytoma","translated_title":"","metadata":{"abstract":"A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.","publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Journal of Neuropathology and Experimental Neurology"},"translated_abstract":"A permanent cell line, S635c15, was derived from an anaplastic astrocytoma induced by the Schmidt-Ruppin strain of avian sarcoma virus (ASV) in a female F-344 rat. Persistent expression of the astrocytic differentiation protein, glial fibrillary acidic protein (GFAP), was detected both in cultured cells after 100 passages in vitro and in transplanted tumors. Subcutaneous and intracerebral transplantation of S635c15 cells in syngeneic rats resulted in a 100% tumor incidence and a reproducible mortality distribution. S635c15 cells formed discrete masses after subcutaneous injection but grew intracranially as infiltrative lesions. Tumor blood flow and blood-to-tissue transport studies yield comparable values to other rat glioma models; S635c15 intracranial tumors proved to be a homogeneous model with little variation within and between tumors with respect to morphology, GFAP expression, blood flow, and permeability. This cell line provides a GFAP-expressing brain tumor model that extends the use of autochthonous ASV-induced astrocytomas by allowing in vitro and in vivo studies. It may be useful for further studies in neurobiology and brain tumor biology, diagnosis, and therapy.","internal_url":"https://www.academia.edu/90996417/A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma","translated_internal_url":"","created_at":"2022-11-17T06:37:02.547-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_Glial_Fibrillary_Acidic_Protein_Expressing_and_Tumorigenic_Cell_Line_Derived_from_an_Avian_Sarcoma_Virus_Induced_Rat_Astrocytoma","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":165,"name":"Pathology","url":"https://www.academia.edu/Documents/in/Pathology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38650,"name":"Cell Division","url":"https://www.academia.edu/Documents/in/Cell_Division"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":118793,"name":"Sarcoma","url":"https://www.academia.edu/Documents/in/Sarcoma"},{"id":153639,"name":"Karyotyping","url":"https://www.academia.edu/Documents/in/Karyotyping"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":485569,"name":"Glial Fibrillary Acidic Protein","url":"https://www.academia.edu/Documents/in/Glial_Fibrillary_Acidic_Protein"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms"},{"id":1757315,"name":"Injections","url":"https://www.academia.edu/Documents/in/Injections"}],"urls":[{"id":26082034,"url":"http://academic.oup.com/jnen/article-pdf/45/6/704/8136883/45-6-704.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996414"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion"><img alt="Research paper thumbnail of Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion" class="work-thumbnail" src="https://attachments.academia-assets.com/94406967/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion">Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, 1985</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0ead4962114287d2fb473cb261fe156d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406967,"asset_id":90996414,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996414"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996414"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996414; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996414]").text(description); $(".js-view-count[data-work-id=90996414]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996414; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996414']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996414, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0ead4962114287d2fb473cb261fe156d" } } $('.js-work-strip[data-work-id=90996414]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996414,"title":"Restricted specificity monoclonal antibodies against murine astrocytomas produced by syngeneic immunization and rat-mouse fusion","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1985,"errors":{}},"publication_name":"Journal of Neuroimmunology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996414/Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion","translated_internal_url":"","created_at":"2022-11-17T06:36:58.533-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406967,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406967/thumbnails/1.jpg","file_name":"0165-5728_2885_2990008-620221117-1-1g60a2d.pdf","download_url":"https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Restricted_specificity_monoclonal_antibo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406967/0165-5728_2885_2990008-620221117-1-1g60a2d-libre.pdf?1668696090=\u0026response-content-disposition=attachment%3B+filename%3DRestricted_specificity_monoclonal_antibo.pdf\u0026Expires=1732748557\u0026Signature=G7LomEJwC7WopdAUzhIfRx939bVz0K-7Bsf8YWBa20wKpkJ-50F8SK1aqBQzz~Jyj07MiLw6eDYTX-E0D8hGCMHg0HBkAn2Nhfaam48HeQorgYRAKh0Ro6aqoDPJ7uKULOAIBCSV50MpEvSkG3nRa-5Nc6CaLAZnbkz~V1F8diPh2U4Nul-l7YufyBdtnsHclbC3G1OZBUEoogpzZWLioiQJtmuDXVCMpU4a1t5H8T2BYUtI~puXJzBdd7Q7yTzuFMdLYWvgMO~RWxMuEGyqR9kwUOigZ67UcWs-WU~uCAWZDMITxl2Se8hXJrBC3kc4wXt4HEgAuEEJNM3aHmkLSQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Restricted_specificity_monoclonal_antibodies_against_murine_astrocytomas_produced_by_syngeneic_immunization_and_rat_mouse_fusion","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406967,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406967/thumbnails/1.jpg","file_name":"0165-5728_2885_2990008-620221117-1-1g60a2d.pdf","download_url":"https://www.academia.edu/attachments/94406967/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Restricted_specificity_monoclonal_antibo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406967/0165-5728_2885_2990008-620221117-1-1g60a2d-libre.pdf?1668696090=\u0026response-content-disposition=attachment%3B+filename%3DRestricted_specificity_monoclonal_antibo.pdf\u0026Expires=1732748557\u0026Signature=G7LomEJwC7WopdAUzhIfRx939bVz0K-7Bsf8YWBa20wKpkJ-50F8SK1aqBQzz~Jyj07MiLw6eDYTX-E0D8hGCMHg0HBkAn2Nhfaam48HeQorgYRAKh0Ro6aqoDPJ7uKULOAIBCSV50MpEvSkG3nRa-5Nc6CaLAZnbkz~V1F8diPh2U4Nul-l7YufyBdtnsHclbC3G1OZBUEoogpzZWLioiQJtmuDXVCMpU4a1t5H8T2BYUtI~puXJzBdd7Q7yTzuFMdLYWvgMO~RWxMuEGyqR9kwUOigZ67UcWs-WU~uCAWZDMITxl2Se8hXJrBC3kc4wXt4HEgAuEEJNM3aHmkLSQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":136892,"name":"Immunization","url":"https://www.academia.edu/Documents/in/Immunization"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996410"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma"><img alt="Research paper thumbnail of Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma" class="work-thumbnail" src="https://attachments.academia-assets.com/94406968/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma">Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma</a></div><div class="wp-workCard_item"><span>Journal of Neuroimmunology</span><span>, 1986</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8b5b7c8272788034ef457864089bfb16" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406968,"asset_id":90996410,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996410"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996410"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996410; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996410]").text(description); $(".js-view-count[data-work-id=90996410]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996410; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996410']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996410, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8b5b7c8272788034ef457864089bfb16" } } $('.js-work-strip[data-work-id=90996410]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996410,"title":"Glioma-associated antigens defined by monoclonal antibodies against an avian sarcoma virus-induced rat astrocytoma","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Summaff $69-c15 is a highly immunogenic cell line derived from an avian sarcoma virus (ASV)-induced astrocytoma in F-344 rats. Monoclonal antibody (Mab) production was attempted by fusing F-344 rat splenocytes and mouse P3 × 63/Ag8.653 myeloma cells after a syngeneic immunization protocol. 336 fusion clones were screened by cell surface radioimmunoassay (CS-RIA) against the immunizing line $69-c15, rat kidney fibroblast line $203-cll and Walker rat carcinoma line. Mabs 7G4, 9F1, 10E3 and 10E7 which reacted only with $69-c15 were chosen. Further analysis demonstrated that these Mabs reacted only with rat (13/23 astrocytomas, 2/4 gliomas, 1/11 neurinomas) or mouse (2/10 astrocytomas) neurogenic tumor cells induced by both viral and chemical agents. Reciprocal competition assays suggested that 7G4, 9F1 and 10E3 recognized the same epitope and that 10E7 reacted with a spatially close determinant. Antigen activity could not be found in adult rat tissues (brain, heart, lung, liver, kidney, spleen, thymus, intestine, muscle and peripheral nerve) and fetal brain (8, 12, 20 days gestation) by either absorption analysis or tissue staining. Preliminary characterization indicated that the epitope may be polypeptide-associated. Further antigen purification and tumor localization can be attempted with these Mabs.","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Journal of Neuroimmunology","grobid_abstract_attachment_id":94406968},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996410/Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma","translated_internal_url":"","created_at":"2022-11-17T06:36:54.558-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406968/thumbnails/1.jpg","file_name":"0165-5728_2886_2990064-020221117-1-sckxlx.pdf","download_url":"https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glioma_associated_antigens_defined_by_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406968/0165-5728_2886_2990064-020221117-1-sckxlx-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DGlioma_associated_antigens_defined_by_mo.pdf\u0026Expires=1732748557\u0026Signature=aahNnUZbOShyUbxKGLFGPsTMmKVnSGha4y9wgOfaFVA7GywFKh0kbui7pwnIdvp-xIPaV~bImPOFnZUNXNIr0uhw6xjvyCe32aWBWhLrh~kZUPR3ATGp55og6luzDKuAjHKa8ylinPcdcCMveIq32sISpyd2GUur83VBgDVMpIRRyxDM8RUspZVGIp-tKc~aFNM2OkRPI3I0TWrC3kb5CNgSHelIIOX8bpGHKjqJ1rKtKV4kfmS~bQEFFdjlWQdelTS4v99D6zT5SXSXrRCJSdkiIixJkxFyElFLdstE681dPxsLLxvJPUytHMl6HlFylAHIRlmHi5l2B64SPRujPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Glioma_associated_antigens_defined_by_monoclonal_antibodies_against_an_avian_sarcoma_virus_induced_rat_astrocytoma","translated_slug":"","page_count":20,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406968,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406968/thumbnails/1.jpg","file_name":"0165-5728_2886_2990064-020221117-1-sckxlx.pdf","download_url":"https://www.academia.edu/attachments/94406968/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glioma_associated_antigens_defined_by_mo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406968/0165-5728_2886_2990064-020221117-1-sckxlx-libre.pdf?1668696092=\u0026response-content-disposition=attachment%3B+filename%3DGlioma_associated_antigens_defined_by_mo.pdf\u0026Expires=1732748557\u0026Signature=aahNnUZbOShyUbxKGLFGPsTMmKVnSGha4y9wgOfaFVA7GywFKh0kbui7pwnIdvp-xIPaV~bImPOFnZUNXNIr0uhw6xjvyCe32aWBWhLrh~kZUPR3ATGp55og6luzDKuAjHKa8ylinPcdcCMveIq32sISpyd2GUur83VBgDVMpIRRyxDM8RUspZVGIp-tKc~aFNM2OkRPI3I0TWrC3kb5CNgSHelIIOX8bpGHKjqJ1rKtKV4kfmS~bQEFFdjlWQdelTS4v99D6zT5SXSXrRCJSdkiIixJkxFyElFLdstE681dPxsLLxvJPUytHMl6HlFylAHIRlmHi5l2B64SPRujPg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":32913,"name":"Neuroimmunology","url":"https://www.academia.edu/Documents/in/Neuroimmunology"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma"},{"id":1159038,"name":"Epitopes","url":"https://www.academia.edu/Documents/in/Epitopes"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":3398462,"name":"epitope","url":"https://www.academia.edu/Documents/in/epitope"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996404"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration"><img alt="Research paper thumbnail of Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration" class="work-thumbnail" src="https://attachments.academia-assets.com/94407036/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration">Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 1989</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="94a3e9edc40e856d19d7a49312e1b206" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94407036,"asset_id":90996404,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996404"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996404"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996404; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996404]").text(description); $(".js-view-count[data-work-id=90996404]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996404; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996404']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996404, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "94a3e9edc40e856d19d7a49312e1b206" } } $('.js-work-strip[data-work-id=90996404]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996404,"title":"Regulation of hepatocyte growth: Alpha-1 adrenergic receptor andras p21 changes in liver regeneration","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Catecholamines, acting via the alpha-l adrenergic receptor, have been demonstrated to influence adult rat hepatocyte DNA synthesis in primary culture and in vivo during liver regeneration following partial hepatectomy (PHX). Earlier investigations have suggested that the alpha-1 effect on DNA synthesis is significant only during the first day following PHX. We examined receptor binding at several early and late time points after surgery, and we observed a significant loss of specific ['H]-prazosin binding to cells isolated from rat livers 48 and 72 hr after PHX. In contrast, the ability of norepinephrine to stimulate inositol phosphate production in isolated cells prelabeled with [3H]-myo-inositol was transiently reduced between 8 and 16 hr, when alpha-1 binding capacity was virtually unchanged. This uncoupling of phosphoinositide turnover from binding was preceded by a drop in hepatic membrane ras p21 content, as assayed by liquid competition radioimmunoassay. The loss of immunoreactive p21 from membranes was significant by 2 hr after PHX. These findings suggest a role for alpha-1 receptors and ras protein in the early events of liver regeneration.","publication_date":{"day":null,"month":null,"year":1989,"errors":{}},"publication_name":"Journal of Cellular Physiology","grobid_abstract_attachment_id":94407036},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996404/Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration","translated_internal_url":"","created_at":"2022-11-17T06:36:50.407-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94407036,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407036/thumbnails/1.jpg","file_name":"jcp.104140020220221117-1-1va7vwm.pdf","download_url":"https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regulation_of_hepatocyte_growth_Alpha_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407036/jcp.104140020220221117-1-1va7vwm-libre.pdf?1668696083=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_hepatocyte_growth_Alpha_1.pdf\u0026Expires=1732748557\u0026Signature=A3AXeuQQboDekd~ck5AP~7pT9i~-tYt2egMT76v~IiRUSAxLmB9eVvCxmfC3byubCBjaVUY45dKWUMZNwrNl2gOUaEkN3NO66vpzGKAnsyEuqxE0yPTFpYtcK2ybWXWBvSsLq3wBWVIQHzc9A1kS5KRXB1Ig41tHkBtkkRIr0YanhaEVjV3ivX0rqFzGoV7PZP6U~ChaN~FMYHOtwSJP2tT-YHN4DTr3gcuy5~RIffazoyR0fK~h9LXHJSt9cg0NfqvdG9xk8OLCXUN6Xv2EfJTIesWYlDF91bB8IHOf85K1mX35HeBIOlte2cYegqnF1mFQy1hiA~jg5kCbUYW2lQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Regulation_of_hepatocyte_growth_Alpha_1_adrenergic_receptor_andras_p21_changes_in_liver_regeneration","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94407036,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94407036/thumbnails/1.jpg","file_name":"jcp.104140020220221117-1-1va7vwm.pdf","download_url":"https://www.academia.edu/attachments/94407036/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Regulation_of_hepatocyte_growth_Alpha_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94407036/jcp.104140020220221117-1-1va7vwm-libre.pdf?1668696083=\u0026response-content-disposition=attachment%3B+filename%3DRegulation_of_hepatocyte_growth_Alpha_1.pdf\u0026Expires=1732748557\u0026Signature=A3AXeuQQboDekd~ck5AP~7pT9i~-tYt2egMT76v~IiRUSAxLmB9eVvCxmfC3byubCBjaVUY45dKWUMZNwrNl2gOUaEkN3NO66vpzGKAnsyEuqxE0yPTFpYtcK2ybWXWBvSsLq3wBWVIQHzc9A1kS5KRXB1Ig41tHkBtkkRIr0YanhaEVjV3ivX0rqFzGoV7PZP6U~ChaN~FMYHOtwSJP2tT-YHN4DTr3gcuy5~RIffazoyR0fK~h9LXHJSt9cg0NfqvdG9xk8OLCXUN6Xv2EfJTIesWYlDF91bB8IHOf85K1mX35HeBIOlte2cYegqnF1mFQy1hiA~jg5kCbUYW2lQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":60915,"name":"Cellular","url":"https://www.academia.edu/Documents/in/Cellular"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":168638,"name":"Inositol","url":"https://www.academia.edu/Documents/in/Inositol"},{"id":177688,"name":"Cellular Physiology","url":"https://www.academia.edu/Documents/in/Cellular_Physiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":404319,"name":"Liver regeneration","url":"https://www.academia.edu/Documents/in/Liver_regeneration"},{"id":555007,"name":"Receptor","url":"https://www.academia.edu/Documents/in/Receptor"},{"id":664203,"name":"Hepatocyte","url":"https://www.academia.edu/Documents/in/Hepatocyte"},{"id":1648955,"name":"Radioimmunoassay","url":"https://www.academia.edu/Documents/in/Radioimmunoassay"},{"id":2235833,"name":"Dna Synthesis","url":"https://www.academia.edu/Documents/in/Dna_Synthesis"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996396"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice"><img alt="Research paper thumbnail of The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice">The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice</a></div><div class="wp-workCard_item"><span>British Journal of Neurosurgery</span><span>, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab&amp;#39;)2 fragments are required.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996396"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996396"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996396; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996396]").text(description); $(".js-view-count[data-work-id=90996396]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996396; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996396']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996396, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996396]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996396,"title":"The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice","translated_title":"","metadata":{"abstract":"ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab\u0026amp;#39;)2 fragments are required.","publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"British Journal of Neurosurgery"},"translated_abstract":"ABSTRACT The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells. In vitro 81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6. In vivo the plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for 131I-81C6 Fab than 131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab\u0026amp;#39;)2 fragments are required.","internal_url":"https://www.academia.edu/90996396/The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice","translated_internal_url":"","created_at":"2022-11-17T06:36:43.780-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Localisation_of_Radiolabeled_Murine_Monoclonal_Antibody_81C6_and_its_Fab_Fragment_in_Human_Glioma_Xenografts_in_Athymic_Mice","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":302037,"name":"In Vivo","url":"https://www.academia.edu/Documents/in/In_Vivo"},{"id":357811,"name":"Antibody","url":"https://www.academia.edu/Documents/in/Antibody"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"},{"id":1686435,"name":"Monoclonal","url":"https://www.academia.edu/Documents/in/Monoclonal"}],"urls":[{"id":26082025,"url":"http://www.tandfonline.com/doi/pdf/10.3109/02688698808992668"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996389"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes"><img alt="Research paper thumbnail of Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes">Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes</a></div><div class="wp-workCard_item"><span>British Journal of Haematology</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996389"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996389"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996389; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996389]").text(description); $(".js-view-count[data-work-id=90996389]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996389; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996389']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996389, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996389]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996389,"title":"Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes","translated_title":"","metadata":{"abstract":"Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.","publisher":"Wiley","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"British Journal of Haematology"},"translated_abstract":"Fourteen paediatric patients with advanced amegakaryocytic thrombocytopenia (AMT) or other bone marrow (BM) failure syndromes were enrolled on one of two phase I/II dose escalation studies of PIXY321. PIXY321 was administered subcutaneously in doses ranging from 250 to 750 mg/m2/d. No dose-limiting toxicity was observed. Peak absolute neutrophil count (ANC) was higher than baseline in all patients. Most transfusion-independent patients demonstrated elevation in haematocrit and/or platelet count. Trilineage haemopoietic responsiveness was evident in the three transfusion-independent patients. In these paediatric populations PIXY321 is well tolerated and merits consideration as a potential therapy.","internal_url":"https://www.academia.edu/90996389/Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes","translated_internal_url":"","created_at":"2022-11-17T06:36:38.021-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Phase_I_II_trial_of_PIXY321_granulocyte_macrophage_colony_stimulating_factor_interleukin_3_fusion_protein_for_treatment_of_inherited_and_acquired_marrow_failure_syndromes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52136,"name":"Platelet","url":"https://www.academia.edu/Documents/in/Platelet"},{"id":53113,"name":"Hematopoietic Stem Cells","url":"https://www.academia.edu/Documents/in/Hematopoietic_Stem_Cells"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant"},{"id":138603,"name":"Thrombocytopenia","url":"https://www.academia.edu/Documents/in/Thrombocytopenia"},{"id":159239,"name":"Bone marrow","url":"https://www.academia.edu/Documents/in/Bone_marrow"},{"id":1159037,"name":"Fusion Protein","url":"https://www.academia.edu/Documents/in/Fusion_Protein"},{"id":1281375,"name":"Hematocrit","url":"https://www.academia.edu/Documents/in/Hematocrit"},{"id":1281380,"name":"Platelet Count","url":"https://www.academia.edu/Documents/in/Platelet_Count"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":3360152,"name":"Absolute Neutrophil Count","url":"https://www.academia.edu/Documents/in/Absolute_Neutrophil_Count"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"}],"urls":[{"id":26082022,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.1998.01012.x"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996384"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity"><img alt="Research paper thumbnail of New Cytokines with Thrombopoietic Activity" class="work-thumbnail" src="https://attachments.academia-assets.com/94406941/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity">New Cytokines with Thrombopoietic Activity</a></div><div class="wp-workCard_item"><span>Clinical Immunotherapeutics</span><span>, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f1459a517fd7b26c669e51d0f8a234ea" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406941,"asset_id":90996384,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996384"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996384"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996384; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996384]").text(description); $(".js-view-count[data-work-id=90996384]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996384; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996384']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996384, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f1459a517fd7b26c669e51d0f8a234ea" } } $('.js-work-strip[data-work-id=90996384]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996384,"title":"New Cytokines with Thrombopoietic Activity","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":1994,"errors":{}},"publication_name":"Clinical Immunotherapeutics"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996384/New_Cytokines_with_Thrombopoietic_Activity","translated_internal_url":"","created_at":"2022-11-17T06:36:33.458-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406941/thumbnails/1.jpg","file_name":"BF0325926020221117-1-2ygvgv.pdf","download_url":"https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_Cytokines_with_Thrombopoietic_Activi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406941/BF0325926020221117-1-2ygvgv-libre.pdf?1668696104=\u0026response-content-disposition=attachment%3B+filename%3DNew_Cytokines_with_Thrombopoietic_Activi.pdf\u0026Expires=1732748557\u0026Signature=bdr6QglPcV8uoCcZThnlw~p27RvBlBE~Mot4a24NnvT1RFYtn8aigYyEYU6mVMPH8NYQDojsFDsIxCtq9HZdj1I~NROxFnp7tNVkTU9a76ij5q-Q7IOWoLKg2K3IXgGS-aN19Of26QM~m18AX0nefnpesyMPFrh0Tv8pdeREU67~btVHBP0xBw2U-qfqM0YjxOmuoO22l-Nh2~67TFg2hJ52cDPXGMcXorpz~GGyRH~UeUIe4AzGEuu~fbqHKeqm3Ev37KKPr~unnl97fmg8hGM98~vV9nvcoPjMMpG~ck1XXtCQou5RsfhTOCDlaI4e3RndR6cS87zQCifOIyGoig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"New_Cytokines_with_Thrombopoietic_Activity","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406941,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406941/thumbnails/1.jpg","file_name":"BF0325926020221117-1-2ygvgv.pdf","download_url":"https://www.academia.edu/attachments/94406941/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"New_Cytokines_with_Thrombopoietic_Activi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406941/BF0325926020221117-1-2ygvgv-libre.pdf?1668696104=\u0026response-content-disposition=attachment%3B+filename%3DNew_Cytokines_with_Thrombopoietic_Activi.pdf\u0026Expires=1732748557\u0026Signature=bdr6QglPcV8uoCcZThnlw~p27RvBlBE~Mot4a24NnvT1RFYtn8aigYyEYU6mVMPH8NYQDojsFDsIxCtq9HZdj1I~NROxFnp7tNVkTU9a76ij5q-Q7IOWoLKg2K3IXgGS-aN19Of26QM~m18AX0nefnpesyMPFrh0Tv8pdeREU67~btVHBP0xBw2U-qfqM0YjxOmuoO22l-Nh2~67TFg2hJ52cDPXGMcXorpz~GGyRH~UeUIe4AzGEuu~fbqHKeqm3Ev37KKPr~unnl97fmg8hGM98~vV9nvcoPjMMpG~ck1XXtCQou5RsfhTOCDlaI4e3RndR6cS87zQCifOIyGoig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":204384,"name":"Haematopoiesis","url":"https://www.academia.edu/Documents/in/Haematopoiesis"},{"id":295233,"name":"Cytokine","url":"https://www.academia.edu/Documents/in/Cytokine"},{"id":3670392,"name":"Thrombopoiesis","url":"https://www.academia.edu/Documents/in/Thrombopoiesis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":26082020,"url":"http://link.springer.com/content/pdf/10.1007/BF03259260.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996381"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts"><img alt="Research paper thumbnail of Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts" class="work-thumbnail" src="https://attachments.academia-assets.com/94406939/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts">Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts</a></div><div class="wp-workCard_item"><span>Biochemical Pharmacology</span><span>, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2c6f8ba93a56f7adbb8c044f1e97804" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94406939,"asset_id":90996381,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996381"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996381"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996381; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996381]").text(description); $(".js-view-count[data-work-id=90996381]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996381; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996381']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996381, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d2c6f8ba93a56f7adbb8c044f1e97804" } } $('.js-work-strip[data-work-id=90996381]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996381,"title":"Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":1988,"errors":{}},"publication_name":"Biochemical Pharmacology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996381/Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts","translated_internal_url":"","created_at":"2022-11-17T06:36:30.893-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":94406939,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406939/thumbnails/1.jpg","file_name":"0006-2952_2888_2990612-020221117-1-11s12e7.pdf","download_url":"https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Buthionine_sulfoximine_mediated_depletio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406939/0006-2952_2888_2990612-020221117-1-11s12e7-libre.pdf?1668696097=\u0026response-content-disposition=attachment%3B+filename%3DButhionine_sulfoximine_mediated_depletio.pdf\u0026Expires=1732748557\u0026Signature=YBpLhQKo5KzAmBafujgmyufGIyxoZAMOS3~EiB8EedjQ5PX3-qXFQ0y02664p5KfJtE2YOzR-TO2CNRRrPJstBcIRaJAJGbBoV1dJQLRwckEDY1wFBxBJ6Lgmm7KkmqCDlpq5c8npcVbdccjsjGWdNY7miNxAaCqVn0jTCXBtuce7F-pKAY71o0Bc7S9HjQtUHD4SiX-43aRlZfA2B-WIE87DUIlYAK8ZX4EXUXmVHnWXNqrc4hS3GaZuadyaTsGyqmMNAlLh9oYsz0l1NVK~nD9C642HLYRz1mm9DIFwzhbjPYwWe5nQzGIpEhNrjXqpSYRjt6XyQnfIUb-4TuAIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Buthionine_sulfoximine_mediated_depletion_of_glutathione_in_intracranial_human_glioma_derived_xenografts","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[{"id":94406939,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94406939/thumbnails/1.jpg","file_name":"0006-2952_2888_2990612-020221117-1-11s12e7.pdf","download_url":"https://www.academia.edu/attachments/94406939/download_file?st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc0NDk1Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Buthionine_sulfoximine_mediated_depletio.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94406939/0006-2952_2888_2990612-020221117-1-11s12e7-libre.pdf?1668696097=\u0026response-content-disposition=attachment%3B+filename%3DButhionine_sulfoximine_mediated_depletio.pdf\u0026Expires=1732748557\u0026Signature=YBpLhQKo5KzAmBafujgmyufGIyxoZAMOS3~EiB8EedjQ5PX3-qXFQ0y02664p5KfJtE2YOzR-TO2CNRRrPJstBcIRaJAJGbBoV1dJQLRwckEDY1wFBxBJ6Lgmm7KkmqCDlpq5c8npcVbdccjsjGWdNY7miNxAaCqVn0jTCXBtuce7F-pKAY71o0Bc7S9HjQtUHD4SiX-43aRlZfA2B-WIE87DUIlYAK8ZX4EXUXmVHnWXNqrc4hS3GaZuadyaTsGyqmMNAlLh9oYsz0l1NVK~nD9C642HLYRz1mm9DIFwzhbjPYwWe5nQzGIpEhNrjXqpSYRjt6XyQnfIUb-4TuAIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":118450,"name":"Glutathione","url":"https://www.academia.edu/Documents/in/Glutathione"},{"id":648326,"name":"BIOCHEMICAL PHARMACOLOGY","url":"https://www.academia.edu/Documents/in/BIOCHEMICAL_PHARMACOLOGY"},{"id":1014097,"name":"Methionine Sulfoximine","url":"https://www.academia.edu/Documents/in/Methionine_Sulfoximine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90996115"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE"><img alt="Research paper thumbnail of 25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE">25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE</a></div><div class="wp-workCard_item"><span>Journal of Neuropathology and Experimental Neurology</span><span>, 1984</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90996115"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90996115"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90996115; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90996115]").text(description); $(".js-view-count[data-work-id=90996115]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90996115; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90996115']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90996115, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90996115]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90996115,"title":"25 GLIOMA-ASSOCIATED ANTIGEN DEFINED BY MONOCLONAL ANTIBODIES (MAs) AGAINST AN AVIAN SARCOMA VIRUS (ASV)-INDUCED RAT ASTROCYTOMA CELL LINE","translated_title":"","metadata":{"publisher":"Oxford University Press (OUP)","publication_date":{"day":null,"month":null,"year":1984,"errors":{}},"publication_name":"Journal of Neuropathology and Experimental Neurology"},"translated_abstract":null,"internal_url":"https://www.academia.edu/90996115/25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE","translated_internal_url":"","created_at":"2022-11-17T06:34:09.719-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":231568456,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"25_GLIOMA_ASSOCIATED_ANTIGEN_DEFINED_BY_MONOCLONAL_ANTIBODIES_MAs_AGAINST_AN_AVIAN_SARCOMA_VIRUS_ASV_INDUCED_RAT_ASTROCYTOMA_CELL_LINE","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":231568456,"first_name":"Yisheng","middle_initials":null,"last_name":"Lee","page_name":"YishengLee5","domain_name":"independent","created_at":"2022-08-10T08:39:54.542-07:00","display_name":"Yisheng Lee","url":"https://independent.academia.edu/YishengLee5"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":8089,"name":"Virology","url":"https://www.academia.edu/Documents/in/Virology"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":76383,"name":"Glioma","url":"https://www.academia.edu/Documents/in/Glioma"},{"id":118793,"name":"Sarcoma","url":"https://www.academia.edu/Documents/in/Sarcoma"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":766014,"name":"Monoclonal Antibody","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibody"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1426713,"name":"Antigen","url":"https://www.academia.edu/Documents/in/Antigen"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "77cc45ef8c3442df6f8b7d00f801a823809f8e55edd917b4464e4cb66d7acb17", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="BX/27LnOxPeWjZWb2EFb54a6mXaHCvAWqrV9VQOtylaIpExOLbkkLCX/kZCaTB+My0jLA6aL7yFpMpl6dIQRAw==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/YishengLee5" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="0fwURL7N6OSgdJnHPREuGmE7NnhGGayZ/2BzcaD8LOBcJ67mKroIPxMGncx/HGpxLMlkDWeYs64855de19X3tQ==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>