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Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","author":[{"@context":"https://schema.org","@type":"Person","name":"Yisheng Lee"}],"contributor":[],"dateCreated":"2022-11-17","dateModified":null,"datePublished":"1987-01-01","headline":"Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration","inLanguage":"en","keywords":["Kinetics","Cancer","Medicine","Cell line","Humans","Glioma","Mice","Animals","Monoclonal Antibodies","Biodistribution","Antibody","Monoclonal Antibody","Radioisotopes","Brain Neoplasms"],"locationCreated":null,"publication":"Cancer research","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" 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Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...","publication_date":"1987,,","publication_name":"Cancer research"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [231568456]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":94406988,"attachmentType":"pdf"}"><img alt="First page of “Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/94406988/mini_magick20221117-1-r5z3ti.png?1668696044" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="231568456" href="https://independent.academia.edu/YishengLee5"><img alt="Profile image of Yisheng Lee" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Yisheng Lee</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">1987, Cancer research</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">7 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 90996435; 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} }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Monoclonal antibody 81C6, which is directed against a human gliomamesenchymal extracellular matrix antigen, was used to evaluate the potential advantage of intracarotid (i.c.) administration versus i.v. delivery to D-54 MG human glioma intracranial xenografts in immunosuppressed rats. Two approaches were taken. In paired-label analysis, 125I-labeled 81C6 and 131I-labeled isotype control antibody were given to separate groups of animals by either the i.v. or i.c. route. Biodistribution measurements as a function of time were analyzed in terms of the percentage of injected dose/g of tissue and localization indices. No significant difference (P greater than 0.19 to P greater than 0.56) was demonstrated between the i.v. and i.c. routes. To control for the large localization variation inherent in the animal model used, an alternative experimental design, paired-injection analysis, was performed in which 125I- and 131I-labeled 81C6 were simultaneously administered by the i.c. and i.v. rou...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":94406988,"attachmentType":"pdf","workUrl":"https://www.academia.edu/90996435/Comparison_of_monoclonal_antibody_delivery_to_intracranial_glioma_xenografts_by_intravenous_and_intracarotid_administration"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" 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ds2-5-body-xs">Journal of Neuroimmunology, 1987</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model","attachmentId":44329558,"attachmentType":"pdf","work_url":"https://www.academia.edu/23944586/Comparative_localization_of_glioma_reactive_monoclonal_antibodies_in_vivo_in_an_athymic_mouse_human_glioma_xenograft_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" 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Bullard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Research</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Production and Characterization of Two Human Glioma Xenograft-localizing Monoclonal Antibodies","attachmentId":44329566,"attachmentType":"pdf","work_url":"https://www.academia.edu/23944621/Production_and_Characterization_of_Two_Human_Glioma_Xenograft_localizing_Monoclonal_Antibodies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23944621/Production_and_Characterization_of_Two_Human_Glioma_Xenograft_localizing_Monoclonal_Antibodies"><span 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js-wsj-grid-card" data-collection-position="3" data-entity-id="23944614" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23944614/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model">Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46247298" href="https://dukemedschool.academia.edu/DennisBullard">Dennis Bullard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1988</p><p class="ds-related-work--abstract ds2-5-body-sm">The development of Mabs, particularly those reactive with primary brain tumors but not with normal brain, provides a potential means of delivering therapeutic agents selectively to human malignant gliomas. Mab 81C6, an IgG2b immunoglobulin, which defines an epitope of the glioma-associated extracellular matrix protein tenascin, has been shown to bind to human glioma cell lines, glioma xenografts in nude mice, and primary human gliomas, but not to normal adult or fetal brain. To test the therapeutic potential of this Mab for targeted delivery of isotopes, nude mice bearing progressively growing s.c. xenografts of D-54 MG, a human glioma cell line, were given injections via the tail vein of either buffer, unlabeled 81C6, 131I-labeled 81C6, or 131I-labeled 45.6, a nonspecific control Mab of the same isotype. Specific activities of the Mab range from 6.0 to 15.5 mCi/mg with protein doses from 7.6 to 167 micrograms. The doses given by injection per animal for labeled 81C6 were 50, 250, 5...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model","attachmentId":44329565,"attachmentType":"pdf","work_url":"https://www.academia.edu/23944614/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23944614/Therapeutic_efficacy_of_antiglioma_mesenchymal_extracellular_matrix_131I_radiolabeled_murine_monoclonal_antibody_in_a_human_glioma_xenograft_model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="99651637" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/99651637/Quantitative_comparison_of_radiolabeled_antibody_therapy_and_external_beam_radiotherapy_in_the_treatment_of_human_glioma_xenografts">Quantitative comparison of radiolabeled antibody therapy and external beam radiotherapy in the treatment of human glioma xenografts</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="229927278" href="https://independent.academia.edu/LarryDillehay">Larry Dillehay</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Radiation Oncology*Biology*Physics, 1992</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Quantitative comparison of radiolabeled antibody therapy and external beam radiotherapy in the treatment of human glioma xenografts","attachmentId":100684296,"attachmentType":"pdf","work_url":"https://www.academia.edu/99651637/Quantitative_comparison_of_radiolabeled_antibody_therapy_and_external_beam_radiotherapy_in_the_treatment_of_human_glioma_xenografts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/99651637/Quantitative_comparison_of_radiolabeled_antibody_therapy_and_external_beam_radiotherapy_in_the_treatment_of_human_glioma_xenografts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="90996428" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6">Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="231568456" href="https://independent.academia.edu/YishengLee5">Yisheng Lee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1988</p><p class="ds-related-work--abstract ds2-5-body-sm">Lack of tumor specificity renders current modalities for treating malignant glioma ineffective. The administration of 131I-labeled monoclonal antibody (Mab) 81C6, which reacts with the glioma-associated extracellular matrix antigen, tenascin, to nude mice carrying s.c. human glioma xenografts has resulted in significant tumor growth delay and tumor regression. In this study, we evaluated the therapeutic efficacy of 131I-labeled 81C6 in athymic rats bearing intracranial human glioma xenografts, a more appropriate model for human gliomas. Mab 81C6, an IgG2b immunoglobulin, and an isotype-matched control Mab, 45.6, were labeled at 12.5-23.6 mCi/mg with chloramine-T. The Mabs were given i.v. at 1.25 and 2.5 mCi/animal for 131I-labeled 81C6, and 1.25 mCi for 131I-labeled 45.6 control. Therapeutic response was evaluated by survival prolongation using Wilcoxon rank sum analysis. Three experiments were done. No significant survival prolongation was found in the trial in which the average tu...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6","attachmentId":94406986,"attachmentType":"pdf","work_url":"https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/90996428/Treatment_of_intracranial_human_glioma_xenografts_with_131I_labeled_anti_tenascin_monoclonal_antibody_81C6"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="34404287" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/34404287/Radioimmunodetection_of_human_glioma_xenografts_by_monoclonal_antibody_to_epidermal_growth_factor_receptor">Radioimmunodetection of human glioma xenografts by monoclonal antibody to epidermal growth factor receptor</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35075800" href="https://independent.academia.edu/AbassAlavi">Abass Alavi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1987</p><p class="ds-related-work--abstract ds2-5-body-sm">Murine IgG2a monoclonal antibody (MAb) 425 specifically detects epidermal growth factor receptor, which is expressed on human gliomas and tumors of other tissue origin but rarely on normal brain tissues, and not at all on bone marrow and peripheral blood cells. 131I-labeled F(ab&#39;)2 fragments of this MAb injected into nude mice grafted with U-87 MG glioma cells preferentially localized in tumor tissue compared to normal mouse tissues, as determined by differential tissue counting of radioactivity. The mean tumor-to-tissue ratios of radioactivity ranged between 8.2 (blood) and 55.8 (muscle) at 2 days after the injection of 15 muCi of 131I-425 F(ab&#39;)2/mouse. Radiolabeled fragments of an anti-hepatitis virus IgG2a MAb did not localize in tumors. The localization index derived from the ratios of specific antibody to indifferent antibody in tumor tissue relative to blood was 9.94 at 2 days following the MAb injection. The labeled MAb did not localize in a xenograft of colorectal c...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Radioimmunodetection of human glioma xenografts by monoclonal antibody to epidermal growth factor receptor","attachmentId":54285649,"attachmentType":"pdf","work_url":"https://www.academia.edu/34404287/Radioimmunodetection_of_human_glioma_xenografts_by_monoclonal_antibody_to_epidermal_growth_factor_receptor","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/34404287/Radioimmunodetection_of_human_glioma_xenografts_by_monoclonal_antibody_to_epidermal_growth_factor_receptor"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="92956603" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92956603/Treatment_of_recurrent_and_cystic_malignant_gliomas_by_a_single_intracavity_injection_of_131I_monoclonal_antibody_feasibility_pharmacokinetics_and_dosimetry">Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58594560" href="https://independent.academia.edu/HughCoakham">Hugh Coakham</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Journal of Cancer, 1993</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetry","attachmentId":95828193,"attachmentType":"pdf","work_url":"https://www.academia.edu/92956603/Treatment_of_recurrent_and_cystic_malignant_gliomas_by_a_single_intracavity_injection_of_131I_monoclonal_antibody_feasibility_pharmacokinetics_and_dosimetry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92956603/Treatment_of_recurrent_and_cystic_malignant_gliomas_by_a_single_intracavity_injection_of_131I_monoclonal_antibody_feasibility_pharmacokinetics_and_dosimetry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="94535375" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94535375/Local_treatment_of_malignant_gliomas_by_direct_infusion_of_specific_monoclonal_antibodies_labeled_with_131I_comparison_of_the_results_obtained_in_recurrent_and_newly_diagnosed_tumors">Local treatment of malignant gliomas by direct infusion of specific monoclonal antibodies labeled with 131I: comparison of the results obtained in recurrent and newly diagnosed tumors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55901434" href="https://independent.academia.edu/agostinoarista">agostino arista</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1995</p><p class="ds-related-work--abstract ds2-5-body-sm">Two murine monoclonal antibodies, BC-2 and BC-4, raised against tenascin and labeled with 131I were infused locally in the site of neoplastic disease by means of a removable (16 patients) or indwelling (34 patients) catheter. Fifty patients bearing a malignant glioma were treated. Twenty-six of these were suffering from recurrent disease; their tumors relapsed within 9 months (median) after treatment. The remaining 24 cases had a newly diagnosed tumor, and local radioimmunotherapy (RIT) was given immediately after surgery and radiochemotherapy. All efforts were made to reduce the tumor before the infusion of the radiopharmaceutical. Therefore, 22 cases with relapsing glioma underwent additional debulking surgery, which led to total or subtotal removal of tumor in 9 of the patients. Altogether, 28 patients had intralesional RIT when the disease was minimal or microscopic. Conversely, 22 cases underwent local RIT with a tumor the diameter of which was &gt; 2 cm. In many cases, the inf...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Local treatment of malignant gliomas by direct infusion of specific monoclonal antibodies labeled with 131I: comparison of the results obtained in recurrent and newly diagnosed tumors","attachmentId":96964076,"attachmentType":"pdf","work_url":"https://www.academia.edu/94535375/Local_treatment_of_malignant_gliomas_by_direct_infusion_of_specific_monoclonal_antibodies_labeled_with_131I_comparison_of_the_results_obtained_in_recurrent_and_newly_diagnosed_tumors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94535375/Local_treatment_of_malignant_gliomas_by_direct_infusion_of_specific_monoclonal_antibodies_labeled_with_131I_comparison_of_the_results_obtained_in_recurrent_and_newly_diagnosed_tumors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="78587058" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78587058/Loco_regional_radioimmunotherapy_of_high_grade_malignant_gliomas_using_specific_monoclonal_antibodies_labeled_with_90Y_a_phase_I_study">Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: a phase I study</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32632191" href="https://independent.academia.edu/NRiva1">N. Riva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical cancer research : an official journal of the American Association for Cancer Research, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">A Phase I radioimmunotherapy trial was conducted in which radioconjugated monoclonal antibody (MAb) was directly infused into the tumor or postoperative tumoral bed in patients with high-grade malignant glioma. BC-4, a murine MAb that recognizes tenascin, was used in these studies. The MAb was labeled with 90Y, a pure beta emitter with maximum energy of 2.284 MeV, which can penetrate into tissue up to 0.5-0.7 cm. Stable 90Y-labeled MAb conjugates were prepared using the chelator p-isothiocyanatobenzyl derivative of diethylenetriaminepentaacetic acid (ITC-Bz-DTPA), obtaining &gt;95% labeling efficiency and conserving the antibodies&#39; immunoreactivity (&gt;85%). Twenty patients, 2 with anaplastic astrocytoma and 18 with glioblastoma, were included in the study. All of the patients had been treated previously with conventional therapies (surgery, external radiotherapy, and chemotherapy) and presented with progressive disease not amenable to further treatment. A dose-escalation study...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: a phase I study","attachmentId":85583562,"attachmentType":"pdf","work_url":"https://www.academia.edu/78587058/Loco_regional_radioimmunotherapy_of_high_grade_malignant_gliomas_using_specific_monoclonal_antibodies_labeled_with_90Y_a_phase_I_study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/78587058/Loco_regional_radioimmunotherapy_of_high_grade_malignant_gliomas_using_specific_monoclonal_antibodies_labeled_with_90Y_a_phase_I_study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":94406988,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":94406988,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_94406988" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="5204778" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5204778/Monoclonal_Antibody_in_Newly_Diagnosed_Patients_with_Malignant_Gliomas_A_Phase_II_Study">Monoclonal Antibody in Newly Diagnosed Patients with Malignant Gliomas: A Phase II Study</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="7079923" href="https://tamu.academia.edu/GamalAkabani">Gamal Akabani</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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js-related-work-sidebar-card" data-collection-position="1" data-entity-id="79492411" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79492411/Visualization_of_Connexin_43_positive_cells_of_glioma_and_the_periglioma_zone_by_means_of_intravenously_injected_monoclonal_antibodies">Visualization of Connexin 43-positive cells of glioma and the periglioma zone by means of intravenously injected monoclonal antibodies</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39555313" href="https://independent.academia.edu/GaukharYusubalieva">Gaukhar Yusubalieva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug Delivery, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" 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style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="13137558" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13137558/Distribution_of_labelled_anti_tenascin_antibodies_and_fragments_after_injection_into_intact_or_partly_resected_C6_gliomas_in_rats">Distribution of labelled anti-tenascin antibodies and fragments after injection into intact or partly resected C6-gliomas in rats</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32393668" href="https://uni-karlsruhe.academia.edu/KlausTatsch">Klaus Tatsch</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer Immunology, Immunotherapy, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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href="https://independent.academia.edu/JohnMcKean7">John McKean</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1991</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Development of a Large-Animal Human Brain Tumor Xenograft Model In Immunosuppressed Cats","attachmentId":79830311,"attachmentType":"pdf","work_url":"https://www.academia.edu/69915782/Development_of_a_Large_Animal_Human_Brain_Tumor_Xenograft_Model_In_Immunosuppressed_Cats","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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Supplement Series B: Biomedical Chemistry, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biodegradation of 125 I-Labeled monoclonal antibodies after intravenous administration to rats with experimental C6 glioma","attachmentId":86195320,"attachmentType":"pdf","work_url":"https://www.academia.edu/79501916/Biodegradation_of_125_I_Labeled_monoclonal_antibodies_after_intravenous_administration_to_rats_with_experimental_C6_glioma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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Schijns</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Anti-Cancer Agents in Medicinal Chemistry, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Immunotherapy of Malignant Gliomas Using Autologous and Allogeneic Tissue Cells","attachmentId":83465067,"attachmentType":"pdf","work_url":"https://www.academia.edu/75791710/Immunotherapy_of_Malignant_Gliomas_Using_Autologous_and_Allogeneic_Tissue_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/75791710/Immunotherapy_of_Malignant_Gliomas_Using_Autologous_and_Allogeneic_Tissue_Cells"><span 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class="ds-related-work--metadata ds2-5-body-xs">Bulletin of Experimental Biology and Medicine, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Treatment of Poorly Differentiated Glioma Using a Combination of Monoclonal Antibodies to Extracellular Connexin-43 Fragment, Temozolomide, and Radiotherapy","attachmentId":114180259,"attachmentType":"pdf","work_url":"https://www.academia.edu/118590386/Treatment_of_Poorly_Differentiated_Glioma_Using_a_Combination_of_Monoclonal_Antibodies_to_Extracellular_Connexin_43_Fragment_Temozolomide_and_Radiotherapy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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ds2-5-body-sm ds2-5-body-link" data-author-id="37320207" href="https://uni-lj.academia.edu/TamaraLah">Tamara Lah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Anticancer research</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Experimental model and immunohistochemical analyses of U87 human glioblastoma cell xenografts in immunosuppressed rat brains","attachmentId":45949327,"attachmentType":"pdf","work_url":"https://www.academia.edu/25619155/Experimental_model_and_immunohistochemical_analyses_of_U87_human_glioblastoma_cell_xenografts_in_immunosuppressed_rat_brains","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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data-author-id="55901434" href="https://independent.academia.edu/agostinoarista">agostino arista</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell Biophysics, 1994</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glioblastoma therapy by direct intralesional administration of I-131 radioiodine labeled antitenascin antibodies","attachmentId":96964042,"attachmentType":"pdf","work_url":"https://www.academia.edu/94535294/Glioblastoma_therapy_by_direct_intralesional_administration_of_I_131_radioiodine_labeled_antitenascin_antibodies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/94535294/Glioblastoma_therapy_by_direct_intralesional_administration_of_I_131_radioiodine_labeled_antitenascin_antibodies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="17952690" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17952690/Development_of_a_method_to_measure_kinetics_of_radiolabelled_monoclonal_antibody_in_human_tumour_with_applications_to_microdosimetry_positron_emission_tomography_studies_of_iodine_124_labelled_3F8_monoclonal_antibody_in_glioma">Development of a method to measure kinetics of radiolabelled monoclonal antibody in human tumour with applications to microdosimetry: positron emission tomography 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