CINXE.COM

<!DOCTYPE html> <html lang="fr" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# "> <head> <title>Comprendre l’hyperoxalurie primitive (HP) | Alnylam® France</title> <meta charset="utf-8" /> <link rel="canonical" href="https://www.alnylam.fr/hyperoxalurie-primitive" /> <link rel="image_src" href="/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="description" content="L’Hyperoxalurie Primitive (HP) constitue un groupe de maladies héréditaires rares du foie caractérisées par la surproduction d’oxalate, un produit final du métabolisme. L’HP1 est la forme la plus courante et la plus grave, représentant 70 à 80 % des cas." /> <meta name="keywords" content="alnylam, alnylam pharmaceuticals, laboratoires arni, arni thérapeutique, interférence arn, médicaments génétiques, maladies cardiométaboliques, maladies hépatiques infectieuses, maladies du système nerveux central, maladies oculaires" /> <meta property="og:url" content="https://www.alnylam.fr/hyperoxalurie-primitive" /> <meta property="og:title" content="Comprendre l’hyperoxalurie primitive (HP) | Alnylam® France" /> <meta property="og:description" content="L’Hyperoxalurie Primitive (HP) constitue un groupe de maladies héréditaires rares du foie caractérisées par la surproduction d’oxalate, un produit final du métabolisme. L’HP1 est la forme la plus courante et la plus grave, représentant 70 à 80 % des cas." /> <meta property="og:image" content="https://www.alnylam.fr/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="twitter:description" content="L’Hyperoxalurie Primitive (HP) constitue un groupe de maladies héréditaires rares du foie caractérisées par la surproduction d’oxalate, un produit final du métabolisme. L’HP1 est la forme la plus courante et la plus grave, représentant 70 à 80 % des cas." /> <meta name="twitter:title" content="Comprendre l’hyperoxalurie primitive (HP) | Alnylam® France" /> <meta name="twitter:url" content="https://www.alnylam.fr/hyperoxalurie-primitive" /> <meta name="twitter:image" content="https://www.alnylam.fr/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="Generator" content="Drupal 9 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/alnylam/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="alternate" hreflang="fr" href="https://www.alnylam.fr/hyperoxalurie-primitive" /> <script src="/sites/default/files/google_tag/primary/google_tag.script.js?snkmi2" defer></script> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/core.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/controlgroup.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/checkboxradio.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/resizable.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/button.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/dialog.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?snkmi2" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/theme.css?snkmi2" /> <link rel="stylesheet" media="all" href="https://use.fontawesome.com/releases/v5.8.2/css/all.css" /> <link rel="stylesheet" media="all" href="/modules/paragraphs/css/paragraphs.unpublished.css?snkmi2" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/css/bootstrap.css" integrity="sha256-0XAFLBbK7DgQ8t7mRWU5BF2OMm9tjtfH945Z7TTeNIo=" crossorigin="anonymous" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/@unicorn-fail/drupal-bootstrap-styles@0.0.2/dist/3.4.0/8.x-3.x/drupal-bootstrap.css" integrity="sha512-j4mdyNbQqqp+6Q/HtootpbGoc2ZX0C/ktbXnauPFEz7A457PB6le79qasOBVcrSrOBtGAm0aVU2SOKFzBl6RhA==" crossorigin="anonymous" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/animate.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/js_composer.min.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/style.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/home-page.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/pages.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/custom.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/to_maintain.css?snkmi2" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/pipeline.css?snkmi2" /> <meta name="google-site-verification" content="wF8nTWS-uAoED-60sNRfPcoR_DhO1j2XObykXt72IJs" /> <link href="https://fonts.googleapis.com/css?family=Source+Sans+Pro:300,300i,400,400i,600,600i,700,700i,900,900i" rel="stylesheet"> </head> <body class="node-15 path-node page-node-type-page has-glyphicons"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-KR7Z8ZV" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <header class="navbar has_top scroll_header_top_area stick menu_bottom scrolled_not_transparent with_border page_header navbar-default container menu_bottom" id="navbar" role="banner"> <div class="navbar-header"> <div class="region region-navigation"> <section id="block-topnav" class="block block-block-content block-block-content7ad3e5f0-bbf9-431a-9b67-137ecd8d72cf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="header_top clearfix" style=""> <div class="container"> <div class="container_inner clearfix"> <div class="left"> <div class="inner"> </div> </div> <div class="right"> <div class="inner"> <div class="header-widget widget_text header-right-widget"> <div class="textwidget"> <div class="top_wrapper_links top-menu" style="padding-right:0;"> <ul> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://www.alnylam.com/about-alnylam/transparency-french-france">Transparence</a></li> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://investors.alnylam.com/">Investisseurs</a></li> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://www.alnylam.com/careers/">Carrières</a></li> <li id="selector_list" style="padding-right:0;"><a href="javascript:void(0);" id="language_selector"><img id="actual-lang" src="/themes/alnylam/images/flags/flag-FR.png" />(FRA)<i aria-hidden="true" class="fa fa-chevron-down"> </i></a> <nav id="languages"> <div class="row row1"> <div class="lang-col"> <div class="lang-cell"><strong id="lang-title-strong">Pays actuel</strong><span id="lang-title-normal"> et options de langue:<span> </span></span></div> </div> <div class="lang-col lang-indicator"> <div class="lang-cell"><img id="actual-lang-inside" src="/themes/alnylam/images/flags/flag-FR.png" /><strong>France</strong> Français (FRA)</div> </div> </div> <div class="row row2"> <ul class="lang-col"> <li class="lang-au ">Autriche <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-austria/" target="_blank">Deutsch</a></li> <li class="lang-be ">Belgique <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-belgium-dutch/" target="_blank">Nederlands</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-belgium-french/" target="_blank">Français</a></li> <li class="lang-br ">Brésil <a data-target="#extSiteModal" data-toggle="modal" href="https://alnylam.com.br" target="_blank">Português</a></li> <li class="lang-ca">Canada <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.ca/fr" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.ca/" target="_blank">English</a></li> <li class="lang-cz">République tchèque <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-czech-republic/" target="_blank">Čeština</a></li> <li class="lang-da">Danemark <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-denmark/" target="_blank">Dansk</a></li> <li class="lang-fr selected-parent">France <a class="selected" href="/">Français</a></li> <li class="lang-de ">Allemagne <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.de/" target="_blank">Deutsch</a></li> <li class="lang-ie ">Irlande <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-ireland/" target="_blank">English</a></li> <li class="lang-it ">Italie <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.it/" target="_blank">Italiano</a></li> </ul> <ul class="lang-col"> <li class="lang-jp ">Japon <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-japan/" target="_blank">Japanese</a></li> <li class="lang-lu ">Luxembourg <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-luxembourg-french/" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-luxembourg-german/" target="_blank">Deutsch</a></li> <li class="lang-nl">Pays-Bas <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-netherlands/" target="_blank">Nederlands</a></li> <li class="lang-pt">Portugal <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-portugal/" target="_blank">Português</a></li> <li class="lang-es">Espagne <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-espana/" target="_blank">Español</a></li> <li class="lang-sv">Suède <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-sverige/" target="_blank">Svenska</a></li> <li class="lang-ch">Suisse <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-french/" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-german/" target="_blank">Deutsch</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-italian/" target="_blank">Italiano</a></li> <li class="lang-tw ">Taiwan <a class="selected" data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-taiwan/" target="_blank">Traditional Chinese</a></li> <li class="lang-uk ">Royaume-Uni <a class="selected" data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-uk/" target="_blank">English</a></li> </ul> <ul class="lang-col last"> <li class="lang-GLOBAL">Global <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/" target="_blank">English</a></li> </ul> <div class="clear-nav"> </div> </div> </nav> <script> //custom title form Canada French if ( document.body.className.match("alnylam-canada-french") ) { document.getElementById("lang-title-normal").innerHTML = " et options de langue :"; } //customized for Global/US menu if ( document.body.className.match( "page-template-full_width_languages-php" ) ) { jQuery( "#languages .row1 .lang-col:not(.lang-indicator) .lang-cell" ).html( "<strong>Current country</strong> and language options:" ); jQuery( "#languages .row1 .lang-col.lang-indicator .lang-cell" ).html( '<img id="actual-lang" src="https://www.alnylam.com/wp-content/themes/bridge-child/img/flags/flag-global.png"> <strong>Global</strong> (ENG)' ); jQuery("li.lang-GLOBAL").addClass("selected-parent"); } </script></li> </ul> </div> <div id="top-bar-mobile"><i class="fa fa-angle-down"> </i></div> </div> </div> </div> </div>  <ul id="global_languages"> </ul> </div> </div> </div> </div> </section> <section id="block-header" class="block block-block-content block-block-contentb248b87e-d1ec-4b92-9a40-a9e24a847599 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div id="main-header"> <header class="has_top scroll_header_top_area stick menu_bottom scrolled_not_transparent with_border page_header"> <div class="header_inner clearfix"> <div class="header_top_bottom_holder"> <div class="header_bottom clearfix"> <div class="container"> <div class="container_inner clearfix"> <div class="header_inner_left"> <div class="mobile_menu_button"><span><i class="qode_icon_font_awesome fa fa-bars "> </i> </span></div> <div class="logo_wrapper"> <div class="q_logo"><a href="/" itemprop="url" style="height: 90px; visibility: visible;"><img alt="Alnylam Pharmaceuticals Logo" class="normal" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> <img alt="Alnylam Pharmaceuticals Logo" class="sticky" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> <img alt="Alnylam Pharmaceuticals Logo" class="mobile" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> </a></div> </div> </div> <div class="header_menu_bottom"> <div class="header_menu_bottom_inner"> <div class="main_menu_header_inner_right_holder"> <nav class="main_menu drop_down"> <ul class="clearfix" id="menu-main-menu"> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16202"><a class="apropos" href="/a-propos-alnylam"><span>À propos<br /> d’Alnylam</span></a></li> <li class="our-science-menu menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16382"><a class="science" href="/notre-science"><span>Notre science</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-20119"><a class="portefeuille" href="/nos-produits-en-developpement"><span>Notre portefeuille<br /> de développement</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children has_sub narrow" id="nav-menu-item-16409"><a class="domaines" href="#"><span>Nos domaines<br /> thérapeutiques</span></a> <div class="second" style="height: 0px;"> <div class="inner"> <ul> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16480"><a class="amylose" href="/amylose" target=""><i class="menu_icon blank fa"> </i><span>Amylose héréditaire à transthyrétine</span></a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16478"><a class="porphyrie" href="/porphyrie-hépatique-aiguë" target=""><i class="menu_icon blank fa"> </i><span>Porphyrie hépatique aiguë</span></a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16479"><a class="hyperoxalurie" href="/hyperoxalurie-primitive" target=""><i class="menu_icon blank fa"> </i><span>Hyperoxalurie primitive de type 1</span></a></li> </ul> </div> </div> </li> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16525"><a class="produits" href="/nos-produits"><span>Nos<br /> produits</span></a></li> <li class="patients-menu menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-15990"><a class="contacter" href="/nous-contacter"><span>Nous contacter</span></a></li> <li class="m3level investors menu-item menu-item-type-custom menu-item-object-custom narrow" id="nav-menu-item-16555"><a class="engagement" href="/notre-engagement"><span>Notre<br /> engagement</span></a></li> </ul> </nav> <div class="header_inner_right"> <div class="side_menu_button_wrapper right"> <div class="side_menu_button"><a class="search_button search_slides_from_window_top normal" href="javascript:void(0)" style="display: none;"><span>Search</span> </a></div> </div> </div> </div> </div> </div> <nav class="mobile_menu"> <ul id="menu-main-menu-1" style="display: none;"> <li class="menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16202"><a href="/a-propos-alnylam"><span>À propos d’Alnylam</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="our-science-menu menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16382"><a href="/notre-science"><span>Notre science</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-20119"><a href="/nos-produits-en-developpement"><span>Notre portefeuille de développement</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children has_sub" id="mobile-menu-item-16409"><a class="domaines" href="#"><span>Nos domaines thérapeutiques</span></a><span class="mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span> <ul class="sub_menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-16364"><a class="amylose" href="/amylose"><span>Amylose héréditaire à transthyrétine</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-17430"><a class="porphyrie" href="/porphyrie-hépatique-aiguë"><span>Porphyrie hépatique aiguë</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-17431"><a class="hyperoxalurie" href="/hyperoxalurie-primitive"><span>Hyperoxalurie primitive de type 1</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> </ul> </li> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16525"><a href="/nos-produits"><span>Nos produits</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="patients-menu menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-15990"><a href="/nous-contacter"><span>Nous contacter</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="m3level investors menu-item menu-item-type-custom menu-item-object-custom" id="mobile-menu-item-16555"><a href="/notre-engagement"><span>Notre engagement</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> </ul> </nav> </div> </div> </div> </div> </div> </header> </div> </div> </section> </div> </div> </header> <div role="main" class="main-container container js-quickedit-main-content"> <div class="row"> <section class="col-sm-12"> <a id="main-content"></a> <div class="region region-content"> <section id="block-interstitialexternalsite" class="block block-block-content block-block-contentd669e2b4-ac98-4fb2-9aab-8bc18270635d clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div aria-labelledby="myModalLabel" class="modal fade in" id="extSiteModal" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>VOUS QUITTEZ À PRÉSENT WWW.ALNYLAM.FR</h3> <h4>Vous êtes maintenant dirigé vers un autre site web.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div> </div> </section> <article data-history-node-id="15" role="article" about="/hyperoxalurie-primitive" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="HYPEROXALURIE PRIMITIVE" class="hidden"></span> <div class="content"> <div class="field field--name-field-header field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--header-image paragraph--view-mode--default"> <div class="field field--name-field-header- field--type-image field--label-hidden field--item"> <img loading="lazy" src="/sites/default/files/2020-12/hyperoxalurie-primitive.jpg" width="1280" height="384" alt="" typeof="foaf:Image" class="img-responsive" /> </div> </div> </div> </div> <div class="field field--name-field-subpage-body field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--page-title paragraph--view-mode--default"> <div class="field field--name-field-page-ti field--type-text field--label-hidden field--item">HYPEROXALURIE PRIMITIVE</div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--intro-para paragraph--view-mode--default"> <div class="field field--name-field-intro-para field--type-text-long field--label-hidden field--items"> <div class="field--item"><h3 class="mb-24 sub-header">Comprendre l’hyperoxalurie primitive de type 1</h3> <p class="alt">L’Hyperoxalurie Primitive (HP) constitue un groupe de maladies héréditaires rares du foie caractérisées par la surproduction d’oxalate, un produit final du métabolisme. Des niveaux élevés d’oxalate sont toxiques car l’oxalate ne peut pas être assimilé par le corps humain et s’accumule dans les reins.</p> <p class="sub-para main-para-2 mt-24">Il existe 3 types d’HP : type 1 (HP1), type 2 (HP2) et type 3 (HP3). L’HP1 est la forme la plus courante et la plus grave, représentant 70 à 80 % des cas. L’HP1 est une maladie héréditaire rare dans laquelle des quantités excessives d’oxalate sont produites par le foie. L’HP1 touche environ 1 à 3 cas par million d’habitants.</p> <p class="sub-para main-para-2 mt-24">La prévalence pourrait être sous-estimée puisque 5% à 10% des patients reçoivent un diagnostic d’hyperoxalurie primitive (HP) lors d’une récidive de la maladie après transplantation rénale. Dans certaines régions, telles que le Moyen-Orient et l’Afrique du Nord, la prévalence génétique de l’HP1 est plus élevée.</p> </div> <div class="field--item"><h3>Quels sont les symptômes de l’HP1 ?</h3> <p class="alignment">Les personnes atteintes d’HP1 sont souvent confrontées à la formation de calculs d’oxalate dans les voies urinaires et les reins. Lorsqu’une personne atteinte d’HP1 a un calcul rénal, les symptômes peuvent comprendre :</p> <div class="col-list"><span class="inline-block"><span class="bullet">•</span>  Douleur au flanc <br /> <span class="bullet">•</span> Infections des voies urinaires </span> <span class="break"> </span> <span class="inline-block"> <span class="bullet">•</span> Miction douloureuse<br /> <span class="bullet">•</span> Sang dans les urines </span></div> <p class="alignment sub-para">Certaines personnes ne sont diagnostiquées qu’après une défaillance rénale et nécessitent une dialyse pour aider à filtrer les déchets du sang.</p> <h3>L’HP1 dans l’organisme</h3> <div class="hyperoxalurie"><img alt="L’hyperoxalurie primitive de type 1 (HP1) dans l'organisme " class="hyperoxalurie desktop" src="/sites/default/files/inline-images/ph1-inside-the-body-lg.png" /><img alt="L’hyperoxalurie primitive de type 1 (HP1) dans l'organisme " class="hyperoxalurie mobile" src="/sites/default/files/inline-images/ph1-inside-the-body-sm.png" /></div> </div> </div> </div> </div> </div> <div class="field field--name-field-body-full-width field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--gray-band paragraph--view-mode--default"> <div class="field field--name-field-gray-band-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h3>Apparition et progression de la maladie</h3> </div> <div class="field--item"><div class="chart"><img alt="Symptômes de l’hyperoxalurie primitive de type 1: petite enfance, enfance, adolescence, et âge adulte " class="desktop" src="/sites/default/files/inline-images/ph1-graphic-lg.png" /><img alt="Symptômes de l’hyperoxalurie primitive de type 1: petite enfance, enfance, adolescence, et âge adulte " class="mobile" src="/sites/default/files/inline-images/ph1-graphic-sm.png" /></div> <p class="left">Les patients peuvent être diagnostiqués d’une HP1 à tout âge, mais la plupart des personnes ressentent leurs premiers symptômes dans la petite enfance.</p> <p class="left">Pour de nombreux patients, l’HP1 n’est pas diagnostiquée immédiatement. Étant donné que les calculs rénaux sont plus courants chez l’adulte, les patients adultes atteints d’HP1 passent souvent de nombreuses années sans être diagnostiqués, jusqu’à ce qu’ils présentent une maladie rénale avancée.</p> <p class="left">À mesure que l’HP1 progresse, elle se traduit souvent par une insuffisance rénale terminale, une affection qui met la vie en danger et qui empêche les reins de filtrer efficacement les fluides et les déchets de l’organisme.</p> <p class="left" style="">Par conséquent, l’accumulation d’oxalate peut entraîner le dépôt de cristaux d’oxalate dans les yeux, les os, la peau, le cœur et le système nerveux central, provoquant une diminution de la vision, des fractures osseuses, des ulcères, une insuffisance cardiaque et d’autres complications.</p> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--wrapper paragraph--view-mode--default"> <div class="field field--name-field-wrapper-content field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--subpage-text paragraph--view-mode--default"> <div class="field field--name-field-sub field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="container img-para-block challenge-accepted pt-32 pb-64"> <div class="ca-img imag-block first-block"><img alt="" src="/sites/default/files/inline-images/PH_resources_Image.png" /></div> <div class="ca-text tex-block first-block"> <h3>Ressources destinées aux patients </h3> <ul> <li class="li-link about-link"><a class="Link " data-target="#extSiteModal" data-toggle="modal" href="https://www.livingwithph1.eu/fr" target="_blank">Vivreavecunehp1.fr</a></li> <li class="li-link about-link"><a class="Link " data-target="#NachrichtenModalInv" data-toggle="modal" href="https://www.airg-france.fr/" target="_blank">AIRG-france.fr </a></li> <li class="li-link about-link second-block"><a class="Link " data-target="#NachrichtenModalInv" data-toggle="modal" href="https://www.facebook.com/AIRG.France" target="_blank">Page Facebook AIRG France</a></li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-strips field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--gray-band paragraph--view-mode--default"> <div class="field field--name-field-wrapper field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--subpage-text paragraph--view-mode--default"> <div class="field field--name-field-sub field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="img-para-block challenge-accepted"> <div class="ca-text tex-block second-block"> <h3>Ressources destinées aux professionnels de santé</h3> <ul> <li class="li-link about-link"><a class="Link" data-target="#extSiteModal" data-toggle="modal" href="https://www.arni-academie.fr/" tabindex="-1" target="_blank">ARNi-academie.fr</a></li> </ul> </div> <div class="ca-img imag-block second-block"><img alt="" src="/sites/default/files/inline-images/professionnels.png" /></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-subpage-body-lower field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--subpage-text paragraph--view-mode--default"> <div class="field field--name-field-sub field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="last-section"> <div class="reference"> <h3 class="reference-h">Références</h3> <p class="reference-p">Edvardsson VO, Goldfarb DS, Lieske JC, et al. Hereditary causes of kidney stones and chronic kidney disease. <em>Peadiatr Nephrol</em>. 2013;28:1923-1942.</p> <p class="reference-p">Hopp K, Cogal A, Bergstralh E, et al. Phenotype-genotype correlations and estimated carrier frequencies of primary hyperoxaluria. <em>J Am Soc Nephrol</em>. 2015;26:2559-2570.</p> <p class="reference-p">Milliner DS, Harris PC, Cogal AG, Lieske JC. Primary hyperoxaluria type 1. <em>GeneReviews</em>, University of Washington, Seattle. 1993-2018.</p> <p class="reference-p">Lorenz EC, Michet CJ, Milliner DS, Lieske JC. Update on oxalate crystal disease. <em>Curr Rheumatol Rep</em>. 2013;7:340.</p> <p class="reference-p">Zhao F, Bergstralh EJ, Mehta RA, et al. Predictors of incident ESRD among patients with primary hyperoxaluria presenting prior to kidney failure. <em>Clin J Am Soc Nephrol</em>. 2016;11:119-126.</p> <p class="reference-p">Hoppe B, Beck BB, Milliner DS. The primary hyperoxalurias. <em>Kidney Int</em>. 2009;75:1264-1271.</p> <p class="reference-p">Cochat P, Deloraine A, Rotily M, Olive F, Liponski I, Deries N. Epidemiology of primary hyperoxaluria type 1. <em>Nephrol Dial Transplant</em>. 1885;10(Suppl 8):3-7.</p> <p class="reference-p">Cochat P, Rumsby G. Primary hyperoxaluria. <em>N Engl J Med</em>. 2013,369:649-658.</p> <p class="reference-p">Harambat J, Fargue S, Acquaviva C, et al. Genotype–phenotype correlation in primary hyperoxaluria type 1: the p.Gly170Arg AGXT mutation is associated with a better outcome. <em>Kidney Int</em>. 2010;77:443–449.</p> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </section> </div> </div> <footer class="footer" role="contentinfo"> <div class="footer_inner clearfix"> <div class="region region-footer"> <section id="block-thiscountryonly" class="block block-block-content block-block-content39174187-173e-4834-b922-a49e2117f37d clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="container_inner"> <div class="this-country-only"> <p>Le contenu de ce site est destiné aux personnes résidant en France.</p> <div class="footer-crop"> <p class="footer-a">Corp-FRA-00009 - Mai 2023</p> <p class="footer-b">© 2023, Alnylam France SAS, Tous droits réservés, RCS 818 575 730 100-102 avenue de Suffren, 75015 Paris, Information Médicale : <a href="mailto:medinfo@alnylam.com">medinfo@alnylam.com</a></p> </div> </div> </div> </div> </section> <section id="block-footer" class="block block-block-content block-block-content5d743e0f-f772-438d-8032-a0a431302739 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="footer_bottom_holder"> <div class="footer_bottom"> <div class="textwidget"> <div class="container_inner"> <div class="top_wrapper_links"><a data-target="#extSiteModal" data-toggle="modal" href="https://alnylampolicies.com/fr/privacy" target="_blank">Politique de confidentialité</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://alnylampolicies.com/fr/legal" target="_blank">Mentions légales </a></div> <div class="left-footer-bottom" style="text-align:right;"><span class="copyright">© 2024 Tous droits réservés Alnylam France</span></div> </div> </div> </div> </div> </div> </section> <section id="block-modalblock" class="block block-block-content block-block-content9998ed11-02eb-4f21-8e5a-fe902231f2d4 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div aria-labelledby="myModalLabel" class="modal fade" id="NachrichtenModal" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>REDIRECTION EN COURS</h3> <h4>Vous quittez à présent www.alnylam.fr pour accéder à notre site Web international (www.alnylam.com), dont le contenu est rédigé en anglais.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div>  <div aria-labelledby="myModalLabel" class="modal fade" id="NachrichtenModalInv" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>VOUS QUITTEZ À PRÉSENT WWW.ALNYLAM.FR</h3> <h4>Le contenu qui suit n'est pas associé à Alnylam Pharmaceuticals. Les liens vers tous les sites extérieurs sont fournis à titre de référence pour nos visiteurs. Alnylam Pharmaceuticals n’approuve pas et n’est pas responsable du contenu des sites qui ne sont ni détenus ni exploités par Alnylam Pharmaceuticals.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div> </div> </section> </div> </div> </footer> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","scriptPath":null,"pathPrefix":"","currentPath":"node\/15","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"fr"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"bootstrap\/popover,core\/drupal.dialog.ajax,fontawesome\/fontawesome.webfonts,paragraphs\/drupal.paragraphs.unpublished,system\/base","theme":"alnylam","theme_token":null},"ajaxTrustedUrl":[],"bootstrap":{"forms_has_error_value_toggle":1,"modal_animation":1,"modal_backdrop":"true","modal_focus_input":1,"modal_keyboard":1,"modal_select_text":1,"modal_show":1,"modal_size":"","popover_enabled":1,"popover_animation":1,"popover_auto_close":1,"popover_container":"body","popover_content":"","popover_delay":"0","popover_html":0,"popover_placement":"right","popover_selector":"","popover_title":"","popover_trigger":"click"},"user":{"uid":0,"permissionsHash":"08edc1283f26d9d2532c3830f65df5230f946390977072fe8869ac8504ebb227"}}</script> <script src="/core/assets/vendor/jquery/jquery.min.js?v=3.6.3"></script> <script src="/core/assets/vendor/underscore/underscore-min.js?v=1.13.6"></script> <script src="/core/misc/polyfills/nodelist.foreach.js?v=9.5.5"></script> <script src="/core/misc/polyfills/element.matches.js?v=9.5.5"></script> <script src="/core/misc/polyfills/object.assign.js?v=9.5.5"></script> <script src="/core/assets/vendor/css-escape/css.escape.js?v=1.5.1"></script> <script src="/core/assets/vendor/es6-promise/es6-promise.auto.min.js?v=4.2.8"></script> <script src="/modules/jquery_migrate/assets/jquery-migrate/jquery-migrate.js?v=3.1.0"></script> <script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script> <script src="/core/assets/vendor/jquery-once/jquery.once.min.js?v=9.5.5"></script> <script src="/core/misc/drupalSettingsLoader.js?v=9.5.5"></script> <script src="/core/misc/drupal.js?v=9.5.5"></script> <script src="/core/misc/drupal.init.js?v=9.5.5"></script> <script src="/core/misc/debounce.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/version-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/data-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/disable-selection-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/focusable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/form-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/ie-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/jquery-patch-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/keycode-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/plugin-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/safe-active-element-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/safe-blur-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/scroll-parent-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/unique-id-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widget-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/controlgroup-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/form-reset-mixin-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/labels-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/mouse-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/checkboxradio-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/draggable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/resizable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/button-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/dialog-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/tabbable/index.umd.min.js?v=5.3.3"></script> <script src="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/js/bootstrap.js" integrity="sha256-29KjXnLtx9a95INIGpEvHDiqV/qydH2bBx0xcznuA6I=" crossorigin="anonymous"></script> <script src="https://player.vimeo.com/api/player.js"></script> <script src="https://cdn.jsdelivr.net/clipboard.js/1.5.10/clipboard.min.js"></script> <script src="/themes/alnylam/js/theme.js?snkmi2"></script> <script src="/themes/alnylam/js/isotope.min.js?snkmi2"></script> <script src="/themes/alnylam/js/waypoints.min.js?snkmi2"></script> <script src="/themes/alnylam/js/js_composer_front.min.js?snkmi2"></script> <script src="/themes/alnylam/js/plugins.js?snkmi2"></script> <script src="/themes/alnylam/js/default-dynamic.js?snkmi2"></script> <script src="/themes/alnylam/js/default.js?snkmi2"></script> <script src="/themes/alnylam/js/jscookie.js?snkmi2"></script> <script src="/themes/alnylam/js/script.js?snkmi2"></script> <script src="/themes/alnylam/js/to_maintain.js?snkmi2"></script> <script src="/themes/alnylam/js/pipeline.js?snkmi2"></script> <script src="/themes/bootstrap/js/drupal.bootstrap.js?snkmi2"></script> <script src="/themes/bootstrap/js/attributes.js?snkmi2"></script> <script src="/themes/bootstrap/js/theme.js?snkmi2"></script> <script src="/themes/bootstrap/js/popover.js?snkmi2"></script> <script src="/core/misc/progress.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/progress.js?snkmi2"></script> <script src="/core/misc/jquery.once.bc.js?v=9.5.5"></script> <script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.2.0"></script> <script src="/core/misc/ajax.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/ajax.js?snkmi2"></script> <script src="/core/misc/displace.js?v=9.5.5"></script> <script src="/core/misc/jquery.tabbable.shim.js?v=9.5.5"></script> <script src="/core/misc/position.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/modal.js?snkmi2"></script> <script src="/themes/bootstrap/js/dialog.js?snkmi2"></script> <script src="/themes/bootstrap/js/modal.jquery.ui.bridge.js?snkmi2"></script> <script src="/core/misc/dialog/dialog.js?v=9.5.5"></script> <script src="/core/misc/dialog/dialog.position.js?v=9.5.5"></script> <script src="/core/misc/dialog/dialog.ajax.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/dialog.ajax.js?snkmi2"></script> </body> </html>