CINXE.COM

<!DOCTYPE html> <html lang="fr" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# "> <head> <title>Comprendre l’amylose héréditaire à transthyrétine (hATTR) | Alnylam® France</title> <meta charset="utf-8" /> <link rel="canonical" href="https://www.alnylam.fr/amylose" /> <link rel="image_src" href="/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="description" content="L’amylose ATTR héréditaire (hATTR) est une maladie héréditaire évolutive causée par une mutation génétique qui entraîne le mauvais repliement des protéines de transthyrétine (TTR). Les symptômes de l’amylose hATTR peuvent varier d’une personne à l’autre." /> <meta name="keywords" content="alnylam, alnylam pharmaceuticals, laboratoires arni, arni thérapeutique, interférence arn, médicaments génétiques, maladies cardiométaboliques, maladies hépatiques infectieuses, maladies du système nerveux central, maladies oculaires" /> <meta property="og:url" content="https://www.alnylam.fr/amylose" /> <meta property="og:title" content="Comprendre l’amylose héréditaire à transthyrétine (hATTR) | Alnylam® France" /> <meta property="og:description" content="L’amylose ATTR héréditaire (hATTR) est une maladie héréditaire évolutive causée par une mutation génétique qui entraîne le mauvais repliement des protéines de transthyrétine (TTR). Les symptômes de l’amylose hATTR peuvent varier d’une personne à l’autre." /> <meta property="og:image" content="https://www.alnylam.fr/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="twitter:description" content="L’amylose ATTR héréditaire (hATTR) est une maladie héréditaire évolutive causée par une mutation génétique qui entraîne le mauvais repliement des protéines de transthyrétine (TTR). Les symptômes de l’amylose hATTR peuvent varier d’une personne à l’autre." /> <meta name="twitter:title" content="Comprendre l’amylose héréditaire à transthyrétine (hATTR) | Alnylam® France" /> <meta name="twitter:url" content="https://www.alnylam.fr/amylose" /> <meta name="twitter:image" content="https://www.alnylam.fr/sites/default/files/2021-07/alnylam-fr-hero-thumb.jpg" /> <meta name="Generator" content="Drupal 9 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/themes/alnylam/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="alternate" hreflang="fr" href="https://www.alnylam.fr/amylose" /> <script src="/sites/default/files/google_tag/primary/google_tag.script.js?sjarup" defer></script> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/core.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/controlgroup.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/checkboxradio.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/resizable.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/button.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/dialog.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?sjarup" /> <link rel="stylesheet" media="all" href="/core/assets/vendor/jquery.ui/themes/base/theme.css?sjarup" /> <link rel="stylesheet" media="all" href="https://use.fontawesome.com/releases/v5.8.2/css/all.css" /> <link rel="stylesheet" media="all" href="/modules/paragraphs/css/paragraphs.unpublished.css?sjarup" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/css/bootstrap.css" integrity="sha256-0XAFLBbK7DgQ8t7mRWU5BF2OMm9tjtfH945Z7TTeNIo=" crossorigin="anonymous" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/@unicorn-fail/drupal-bootstrap-styles@0.0.2/dist/3.4.0/8.x-3.x/drupal-bootstrap.css" integrity="sha512-j4mdyNbQqqp+6Q/HtootpbGoc2ZX0C/ktbXnauPFEz7A457PB6le79qasOBVcrSrOBtGAm0aVU2SOKFzBl6RhA==" crossorigin="anonymous" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/animate.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/js_composer.min.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/style.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/home-page.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/pages.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/custom.css?sjarup" /> <link rel="stylesheet" media="all" href="/themes/alnylam/css/to_maintain.css?sjarup" /> <meta name="google-site-verification" content="wF8nTWS-uAoED-60sNRfPcoR_DhO1j2XObykXt72IJs" /> <link href="https://fonts.googleapis.com/css?family=Source+Sans+Pro:300,300i,400,400i,600,600i,700,700i,900,900i" rel="stylesheet"> </head> <body class="node-13 path-node page-node-type-page has-glyphicons"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-KR7Z8ZV" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <header class="navbar has_top scroll_header_top_area stick menu_bottom scrolled_not_transparent with_border page_header navbar-default container menu_bottom" id="navbar" role="banner"> <div class="navbar-header"> <div class="region region-navigation"> <section id="block-topnav" class="block block-block-content block-block-content7ad3e5f0-bbf9-431a-9b67-137ecd8d72cf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="header_top clearfix" style=""> <div class="container"> <div class="container_inner clearfix"> <div class="left"> <div class="inner"> </div> </div> <div class="right"> <div class="inner"> <div class="header-widget widget_text header-right-widget"> <div class="textwidget"> <div class="top_wrapper_links top-menu" style="padding-right:0;"> <ul> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://www.alnylam.com/about-alnylam/transparency-french-france">Transparence</a></li> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://investors.alnylam.com/">Investisseurs</a></li> <li><a data-target="#NachrichtenModal" data-toggle="modal" href="https://www.alnylam.com/careers/">Carrières</a></li> <li id="selector_list" style="padding-right:0;"><a href="javascript:void(0);" id="language_selector"><img id="actual-lang" src="/themes/alnylam/images/flags/flag-FR.png" />(FRA)<i aria-hidden="true" class="fa fa-chevron-down"> </i></a> <nav id="languages"> <div class="row row1"> <div class="lang-col"> <div class="lang-cell"><strong id="lang-title-strong">Pays actuel</strong><span id="lang-title-normal"> et options de langue:<span> </span></span></div> </div> <div class="lang-col lang-indicator"> <div class="lang-cell"><img id="actual-lang-inside" src="/themes/alnylam/images/flags/flag-FR.png" /><strong>France</strong> Français (FRA)</div> </div> </div> <div class="row row2"> <ul class="lang-col"> <li class="lang-au ">Autriche <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-austria/" target="_blank">Deutsch</a></li> <li class="lang-be ">Belgique <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-belgium-dutch/" target="_blank">Nederlands</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-belgium-french/" target="_blank">Français</a></li> <li class="lang-br ">Brésil <a data-target="#extSiteModal" data-toggle="modal" href="https://alnylam.com.br" target="_blank">Português</a></li> <li class="lang-ca">Canada <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.ca/fr" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.ca/" target="_blank">English</a></li> <li class="lang-cz">République tchèque <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-czech-republic/" target="_blank">Čeština</a></li> <li class="lang-da">Danemark <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-denmark/" target="_blank">Dansk</a></li> <li class="lang-fr selected-parent">France <a class="selected" href="/">Français</a></li> <li class="lang-de ">Allemagne <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.de/" target="_blank">Deutsch</a></li> <li class="lang-ie ">Irlande <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-ireland/" target="_blank">English</a></li> <li class="lang-it ">Italie <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.it/" target="_blank">Italiano</a></li> </ul> <ul class="lang-col"> <li class="lang-jp ">Japon <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-japan/" target="_blank">Japanese</a></li> <li class="lang-lu ">Luxembourg <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-luxembourg-french/" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-luxembourg-german/" target="_blank">Deutsch</a></li> <li class="lang-nl">Pays-Bas <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-netherlands/" target="_blank">Nederlands</a></li> <li class="lang-pt">Portugal <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-portugal/" target="_blank">Português</a></li> <li class="lang-es">Espagne <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-espana/" target="_blank">Español</a></li> <li class="lang-sv">Suède <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-sverige/" target="_blank">Svenska</a></li> <li class="lang-ch">Suisse <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-french/" target="_blank">Français</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-german/" target="_blank">Deutsch</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-switzerland-italian/" target="_blank">Italiano</a></li> <li class="lang-tw ">Taiwan <a class="selected" data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-taiwan/" target="_blank">Traditional Chinese</a></li> <li class="lang-uk ">Royaume-Uni <a class="selected" data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/alnylam-uk/" target="_blank">English</a></li> </ul> <ul class="lang-col last"> <li class="lang-GLOBAL">Global <a data-target="#extSiteModal" data-toggle="modal" href="https://www.alnylam.com/" target="_blank">English</a></li> </ul> <div class="clear-nav"> </div> </div> </nav> <script> //custom title form Canada French if ( document.body.className.match("alnylam-canada-french") ) { document.getElementById("lang-title-normal").innerHTML = " et options de langue :"; } //customized for Global/US menu if ( document.body.className.match( "page-template-full_width_languages-php" ) ) { jQuery( "#languages .row1 .lang-col:not(.lang-indicator) .lang-cell" ).html( "<strong>Current country</strong> and language options:" ); jQuery( "#languages .row1 .lang-col.lang-indicator .lang-cell" ).html( '<img id="actual-lang" src="https://www.alnylam.com/wp-content/themes/bridge-child/img/flags/flag-global.png"> <strong>Global</strong> (ENG)' ); jQuery("li.lang-GLOBAL").addClass("selected-parent"); } </script></li> </ul> </div> <div id="top-bar-mobile"><i class="fa fa-angle-down"> </i></div> </div> </div> </div> </div>  <ul id="global_languages"> </ul> </div> </div> </div> </div> </section> <section id="block-header" class="block block-block-content block-block-contentb248b87e-d1ec-4b92-9a40-a9e24a847599 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div id="main-header"> <header class="has_top scroll_header_top_area stick menu_bottom scrolled_not_transparent with_border page_header"> <div class="header_inner clearfix"> <div class="header_top_bottom_holder"> <div class="header_bottom clearfix"> <div class="container"> <div class="container_inner clearfix"> <div class="header_inner_left"> <div class="mobile_menu_button"><span><i class="qode_icon_font_awesome fa fa-bars "> </i> </span></div> <div class="logo_wrapper"> <div class="q_logo"><a href="/" itemprop="url" style="height: 90px; visibility: visible;"><img alt="Alnylam Pharmaceuticals Logo" class="normal" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> <img alt="Alnylam Pharmaceuticals Logo" class="sticky" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> <img alt="Alnylam Pharmaceuticals Logo" class="mobile" itemprop="image" src="/sites/default/files/inline-images/Logo_Alnylam_460-1.png" style="height: 100%;" /> </a></div> </div> </div> <div class="header_menu_bottom"> <div class="header_menu_bottom_inner"> <div class="main_menu_header_inner_right_holder"> <nav class="main_menu drop_down"> <ul class="clearfix" id="menu-main-menu"> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16202"><a class="apropos" href="/a-propos-alnylam"><span>À propos<br /> d’Alnylam</span></a></li> <li class="our-science-menu menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16382"><a class="science" href="/notre-science"><span>Notre science</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-20119"><a class="portefeuille" href="/nos-produits-en-developpement"><span>Notre portefeuille<br /> de développement</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children has_sub narrow" id="nav-menu-item-16409"><a class="domaines" href="#"><span>Nos domaines<br /> thérapeutiques</span></a> <div class="second" style="height: 0px;"> <div class="inner"> <ul> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16480"><a class="amylose" href="/amylose" target=""><i class="menu_icon blank fa"> </i><span>Amylose héréditaire à transthyrétine</span></a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16478"><a class="porphyrie" href="/porphyrie-hépatique-aiguë" target=""><i class="menu_icon blank fa"> </i><span>Porphyrie hépatique aiguë</span></a></li> <li class="menu-item menu-item-type-custom menu-item-object-custom " id="nav-menu-item-16479"><a class="hyperoxalurie" href="/hyperoxalurie-primitive" target=""><i class="menu_icon blank fa"> </i><span>Hyperoxalurie primitive de type 1</span></a></li> </ul> </div> </div> </li> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-16525"><a class="produits" href="/nos-produits"><span>Nos<br /> produits</span></a></li> <li class="patients-menu menu-item menu-item-type-post_type menu-item-object-page narrow" id="nav-menu-item-15990"><a class="contacter" href="/nous-contacter"><span>Nous contacter</span></a></li> <li class="m3level investors menu-item menu-item-type-custom menu-item-object-custom narrow" id="nav-menu-item-16555"><a class="engagement" href="/notre-engagement"><span>Notre<br /> engagement</span></a></li> </ul> </nav> <div class="header_inner_right"> <div class="side_menu_button_wrapper right"> <div class="side_menu_button"><a class="search_button search_slides_from_window_top normal" href="javascript:void(0)" style="display: none;"><span>Search</span> </a></div> </div> </div> </div> </div> </div> <nav class="mobile_menu"> <ul id="menu-main-menu-1" style="display: none;"> <li class="menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16202"><a href="/a-propos-alnylam"><span>À propos d’Alnylam</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="our-science-menu menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16382"><a href="/notre-science"><span>Notre science</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-20119"><a href="/nos-produits-en-developpement"><span>Notre portefeuille de développement</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children has_sub" id="mobile-menu-item-16409"><a class="domaines" href="#"><span>Nos domaines thérapeutiques</span></a><span class="mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span> <ul class="sub_menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-16364"><a class="amylose" href="/amylose"><span>Amylose héréditaire à transthyrétine</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-17430"><a class="porphyrie" href="/porphyrie-hépatique-aiguë"><span>Porphyrie hépatique aiguë</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="menu-item menu-item-type-post_type menu-item-object-page " id="mobile-menu-item-17431"><a class="hyperoxalurie" href="/hyperoxalurie-primitive"><span>Hyperoxalurie primitive de type 1</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> </ul> </li> <li class="m3level menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-16525"><a href="/nos-produits"><span>Nos produits</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="patients-menu menu-item menu-item-type-post_type menu-item-object-page" id="mobile-menu-item-15990"><a href="/nous-contacter"><span>Nous contacter</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> <li class="m3level investors menu-item menu-item-type-custom menu-item-object-custom" id="mobile-menu-item-16555"><a href="/notre-engagement"><span>Notre engagement</span></a><span class="show-mob mobile_arrow"><i class="fa fa-angle-right"> </i><i class="fa fa-angle-down"> </i></span></li> </ul> </nav> </div> </div> </div> </div> </div> </header> </div> </div> </section> </div> </div> </header> <div role="main" class="main-container container js-quickedit-main-content"> <div class="row"> <section class="col-sm-12"> <a id="main-content"></a> <div class="region region-content"> <section id="block-interstitialexternalsite" class="block block-block-content block-block-contentd669e2b4-ac98-4fb2-9aab-8bc18270635d clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div aria-labelledby="myModalLabel" class="modal fade in" id="extSiteModal" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>VOUS QUITTEZ À PRÉSENT WWW.ALNYLAM.FR</h3> <h4>Vous êtes maintenant dirigé vers un autre site web.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div> </div> </section> <article data-history-node-id="13" role="article" about="/amylose" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="For hATTR" class="hidden"></span> <div class="content"> <div class="field field--name-field-header field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--header-image paragraph--view-mode--default"> <div class="field field--name-field-header- field--type-image field--label-hidden field--item"> <img loading="lazy" src="/sites/default/files/2020-11/hero-module.png" width="1280" height="384" alt="" typeof="foaf:Image" class="img-responsive" /> </div> </div> </div> </div> <div class="field field--name-field-subpage-body field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--intro-para paragraph--view-mode--default"> <div class="field field--name-field-intro-para field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="second-section-wrapper"> <h1 class="title">Amylose héréditaire à transthyrétine</h1> <h3 class="sub-title">Comprendre l’amylose héréditaire à transthyrétine hATTR</h3> <p class="descr alt">L’amylose ATTR héréditaire (hATTR) est une maladie héréditaire évolutive causée par une mutation génétique qui entraîne le mauvais repliement des protéines de transthyrétine (TTR). Il en résulte la formation de fibrilles amyloïdes pouvant se déposer dans les nerfs, le cœur et/ou le tractus gastro-intestinal (GI).</p> <p class="sub-descr alt">L’amylose hATTR touche environ 50 000 personnes dans le monde. De nombreuses personnes demeurent non ou mal diagnostiquées.</p> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--intro-para paragraph--view-mode--default"> <div class="field field--name-field-intro-para field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="div-wrapper"> <h3 class="sub-title mt-0 mb-24">Comment amylose hATTR affecte-t-elle l’organisme ?</h3> <div class="third-section-wrapper"> <div class="third-descr"> <p class="third-para">Les personnes atteintes d’amylose hATTR sont porteuses d’une mutation génétique qui empêche la protéine TTR, fabriquée dans le foie, d’adopter sa structure normale. La TTR, au contraire, se replie mal et s’accumule sous forme de dépôts amyloïdes dans l’organisme, notamment le cœur, les nerfs et le tractus GI ainsi que d’autres organes, ce qui entraîne des symptômes invalidants.</p> </div> <div class="first-image"><img alt="L’amylose ATTR héréditaire (hATTR) - la TTR se replie mal et s’accumule sous forme de dépôts amyloïdes" class="img-responsive" src="/sites/default/files/inline-images/amyloidosis-graphic.png" /></div> </div> </div> <div class="sec-part"> <div class="second-image"><img alt="" data-entity-type="file" data-entity-uuid="e4dafb82-9858-4de8-bb42-6c82160234bd" src="/sites/default/files/inline-images/image2131.png" width="470" height="304" loading="lazy" /></div> <div class="dev-flex"> <h3 class="second-head">Symptômes associés à cette maladie</h3> <p class="second-para mt-0">Les symptômes de l’amylose hATTR peuvent varier d’une personne à l’autre, en fonction des organes ou des tissus touchés, et peuvent s’aggraver à mesure que la maladie évolue. Les symptômes peuvent comprendre :</p> <ul class="colored-ul mt-0 pt-0"><li>Perte de sensibilité, faiblesse et douleur dans les membres</li> <li>Alternance d’épisodes de diarrhée, constipation, nausées et vomissements</li> <li>Problèmes cardiaques</li> </ul></div> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-body-full-width field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--gray-band paragraph--view-mode--default"> <div class="field field--name-field-gray-band-content field--type-text-long field--label-hidden field--items"> <div class="field--item"><h3 class="science-h3 pt-0 pour mt-0 mb-32">En savoir plus sur l'amylose héréditaire à transthyrétine</h3> </div> </div> <div class="field field--name-field-wrapper field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--video-flex paragraph--view-mode--default"> <div class="field field--name-field-video-flex field--type-entity-reference-revisions field--label-above"> <div class="field--label">Video Flex</div> <div class="field--items"> <div class="field--item"> <div class="paragraph paragraph--type--video paragraph--view-mode--default"> <div class="field field--name-field-video-icon- field--type-text-long field--label-hidden field--item"><p><a class="take-link"><img alt="" src="/sites/default/files/video/Jean-Christophe-Vivre-avec-l-hATTR.png" /></a></p> </div> <div class="field field--name-field-video-link field--type-string field--label-hidden field--item">https://www.youtube.com/embed/IoijwWPYjNo?rel=0&amp;autoplay=1</div> <div class="field field--name-field-video-title field--type-string field--label-hidden field--item">Jean-Christophe:</div> <div class="field field--name-field-video-describtion field--type-string field--label-hidden field--item">Vivre avec l’hATTR</div> </div> </div> </div> </div> <div class="field field--name-field-video-popup field--type-text-long field--label-above"> <div class="field--label">Video Popup</div> <div class="field--item"><div aria-labelledby="myModalLabel" class="modal fade" id="Videopopup" role="dialog" tabindex="-1"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span></button></div> <div class="modal-body modal-data"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--wrapper paragraph--view-mode--default"> <div class="field field--name-field-wrapper-content field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--subpage-text paragraph--view-mode--default"> <div class="field field--name-field-sub field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="container challenge-accepted fix-spacing"> <div class="ca-img"><img alt="" data-entity-type="file" data-entity-uuid="2c7588e4-4eaa-4e99-8dc9-0c4cf1a8b954" src="/sites/default/files/inline-images/module-52.png" width="470" height="304" loading="lazy" /></div> <div class="ca-text"> <h3>Ressources destinées<br /> aux patients</h3> <ul><li class="li-link"><a class="Link" data-target="#extSiteModal" data-toggle="modal" href="https://www.hattrbridge.fr/" target="_blank">Hattrbridge.fr</a></li> <li class="li-link"><a class="Link" data-target="#NachrichtenModalInv" data-toggle="modal" href="https://www.Amylose.asso.fr/" target="_blank">Amylose.asso.fr</a></li> </ul></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--gray-band paragraph--view-mode--default"> <div class="field field--name-field-wrapper field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--subpage-text paragraph--view-mode--default"> <div class="field field--name-field-sub field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="challenge-accepted"> <div class="ca-text"> <h3>Ressources destinées aux professionnels de santé</h3> <ul><li class="li-link"><a class="Link" data-target="#extSiteModal" data-toggle="modal" href="https://www.Attryvoirplusclair.fr/" target="_blank">Attryvoirplusclair.fr</a></li> <li class="li-link"><a class="Link" data-target="#extSiteModal" data-toggle="modal" href="https://hattramyloidosis.fr/
" target="_blank">Hattramyloidosis.fr</a></li> <li class="li-link"><a class="Link" data-target="#extSiteModal" data-toggle="modal" href="https://www.arni-academie.fr/
" target="_blank">Arni-academie.fr</a></li> </ul></div> <div class="ca-img"><img alt="" data-entity-type="file" data-entity-uuid="642692db-0aad-4df8-920f-03cbe02c9463" src="/sites/default/files/inline-images/section-3.png" /></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--wrapper paragraph--view-mode--default"> <div class="field field--name-field-wrapper-content field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--intro-para paragraph--view-mode--default"> <div class="field field--name-field-intro-para field--type-text-long field--label-hidden field--items"> <div class="field--item"><div class="last-section"> <div class="reference"> <h3 class="reference-h">Références</h3> <p class="reference-p">Gertz MA, Benson MD, Dyck PJ, et al. <em>J Am Coll Cardiol</em>. 2015;66(21):2451-2466.</p> <p class="reference-p">Hawkins PN, Ando Y, Dispenzeri A, et al. <em>Ann Med</em>. 2015;47(8):625-638.</p> <p class="reference-p">Plante-Bordeneuve V. <em>J Neurol</em>. 2014;261(6):1227-1233.</p> <p class="reference-p">Hanna M. <em>Curr Heart Fail Rep</em>. 2014;11(1):50-57.</p> <p class="reference-p">Damy T, Judge DP, Kristen AV, et al. <em>J Cardiovasc Transl Res</em>. 2015;8(2):117-127.</p> <p class="reference-p">Conceição I, González-Duarte A, Obici L, et al. <em>J Peripher Nerv Syst</em>. 2016;21(1):5-9.</p> <p class="reference-p">Mohty D, Damy T, Cosnay P, et al. <em>Arch Cardiovasc Dis</em>. 2013;106(10):528-540.</p> <p class="reference-p">Sekijima Y, Yoshida K, Tokuda T, Ikeda S. 2001 Nov 5 [Updated 2012 Jan 26]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. <em>GeneReviews</em>® [Internet]. Seattle, WA: University of Washington, Seattle; 1993-2017. <a href="https://www.ncbi.nlm.nih.gov/books/NBK1194/">https://www.ncbi.nlm.nih.gov/books/NBK1194/</a>.</p> <p class="reference-p">Ando Y, Coelho T, Berk JL, et al. <em>Orphanet J Rare Dis</em>. 2013;8:31.</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </section> </div> </div> <footer class="footer" role="contentinfo"> <div class="footer_inner clearfix"> <div class="region region-footer"> <section id="block-thiscountryonly" class="block block-block-content block-block-content39174187-173e-4834-b922-a49e2117f37d clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="container_inner"> <div class="this-country-only"> <p>Le contenu de ce site est destiné aux personnes résidant en France.</p> <div class="footer-crop"> <p class="footer-a">Corp-FRA-00009 - Mai 2023</p> <p class="footer-b">© 2023, Alnylam France SAS, Tous droits réservés, RCS 818 575 730 100-102 avenue de Suffren, 75015 Paris, Information Médicale : <a href="mailto:medinfo@alnylam.com">medinfo@alnylam.com</a></p> </div> </div> </div> </div> </section> <section id="block-footer" class="block block-block-content block-block-content5d743e0f-f772-438d-8032-a0a431302739 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="footer_bottom_holder"> <div class="footer_bottom"> <div class="textwidget"> <div class="container_inner"> <div class="top_wrapper_links"><a data-target="#extSiteModal" data-toggle="modal" href="https://alnylampolicies.com/fr/privacy" target="_blank">Politique de confidentialité</a> <a data-target="#extSiteModal" data-toggle="modal" href="https://alnylampolicies.com/fr/legal" target="_blank">Mentions légales </a></div> <div class="left-footer-bottom" style="text-align:right;"><span class="copyright">© 2024 Tous droits réservés Alnylam France</span></div> </div> </div> </div> </div> </div> </section> <section id="block-modalblock" class="block block-block-content block-block-content9998ed11-02eb-4f21-8e5a-fe902231f2d4 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div aria-labelledby="myModalLabel" class="modal fade" id="NachrichtenModal" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>REDIRECTION EN COURS</h3> <h4>Vous quittez à présent www.alnylam.fr pour accéder à notre site Web international (www.alnylam.com), dont le contenu est rédigé en anglais.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div>  <div aria-labelledby="myModalLabel" class="modal fade" id="NachrichtenModalInv" role="dialog" tabindex="-1"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"><button aria-label="Close" class="close" data-dismiss="modal" type="button"><span aria-hidden="true">X</span></button></div> <div class="modal-body"> <h3>VOUS QUITTEZ À PRÉSENT WWW.ALNYLAM.FR</h3> <h4>Le contenu qui suit n'est pas associé à Alnylam Pharmaceuticals. Les liens vers tous les sites extérieurs sont fournis à titre de référence pour nos visiteurs. Alnylam Pharmaceuticals n’approuve pas et n’est pas responsable du contenu des sites qui ne sont ni détenus ni exploités par Alnylam Pharmaceuticals.</h4> <a class="sgcboxClose" href="http://news.alnylam.com/" id="popup_cta" rel="noopener" target="_blank">Poursuivre ›</a></div> </div> </div> </div> </div> </section> </div> </div> </footer> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","scriptPath":null,"pathPrefix":"","currentPath":"node\/13","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"fr"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"bootstrap\/popover,core\/drupal.dialog.ajax,fontawesome\/fontawesome.webfonts,paragraphs\/drupal.paragraphs.unpublished,system\/base","theme":"alnylam","theme_token":null},"ajaxTrustedUrl":[],"bootstrap":{"forms_has_error_value_toggle":1,"modal_animation":1,"modal_backdrop":"true","modal_focus_input":1,"modal_keyboard":1,"modal_select_text":1,"modal_show":1,"modal_size":"","popover_enabled":1,"popover_animation":1,"popover_auto_close":1,"popover_container":"body","popover_content":"","popover_delay":"0","popover_html":0,"popover_placement":"right","popover_selector":"","popover_title":"","popover_trigger":"click"},"user":{"uid":0,"permissionsHash":"08edc1283f26d9d2532c3830f65df5230f946390977072fe8869ac8504ebb227"}}</script> <script src="/core/assets/vendor/jquery/jquery.min.js?v=3.6.3"></script> <script src="/core/assets/vendor/underscore/underscore-min.js?v=1.13.6"></script> <script src="/core/misc/polyfills/nodelist.foreach.js?v=9.5.5"></script> <script src="/core/misc/polyfills/element.matches.js?v=9.5.5"></script> <script src="/core/misc/polyfills/object.assign.js?v=9.5.5"></script> <script src="/core/assets/vendor/css-escape/css.escape.js?v=1.5.1"></script> <script src="/core/assets/vendor/es6-promise/es6-promise.auto.min.js?v=4.2.8"></script> <script src="/modules/jquery_migrate/assets/jquery-migrate/jquery-migrate.js?v=3.1.0"></script> <script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script> <script src="/core/assets/vendor/jquery-once/jquery.once.min.js?v=9.5.5"></script> <script src="/core/misc/drupalSettingsLoader.js?v=9.5.5"></script> <script src="/core/misc/drupal.js?v=9.5.5"></script> <script src="/core/misc/drupal.init.js?v=9.5.5"></script> <script src="/core/misc/debounce.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/version-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/data-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/disable-selection-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/focusable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/form-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/ie-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/jquery-patch-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/keycode-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/plugin-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/safe-active-element-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/safe-blur-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/scroll-parent-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/unique-id-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widget-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/controlgroup-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/form-reset-mixin-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/labels-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/mouse-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/checkboxradio-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/draggable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/resizable-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/button-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/jquery.ui/ui/widgets/dialog-min.js?v=9.5.5"></script> <script src="/core/assets/vendor/tabbable/index.umd.min.js?v=5.3.3"></script> <script src="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/js/bootstrap.js" integrity="sha256-29KjXnLtx9a95INIGpEvHDiqV/qydH2bBx0xcznuA6I=" crossorigin="anonymous"></script> <script src="https://player.vimeo.com/api/player.js"></script> <script src="https://cdn.jsdelivr.net/clipboard.js/1.5.10/clipboard.min.js"></script> <script src="/themes/alnylam/js/theme.js?sjarup"></script> <script src="/themes/alnylam/js/isotope.min.js?sjarup"></script> <script src="/themes/alnylam/js/waypoints.min.js?sjarup"></script> <script src="/themes/alnylam/js/js_composer_front.min.js?sjarup"></script> <script src="/themes/alnylam/js/plugins.js?sjarup"></script> <script src="/themes/alnylam/js/default-dynamic.js?sjarup"></script> <script src="/themes/alnylam/js/default.js?sjarup"></script> <script src="/themes/alnylam/js/jscookie.js?sjarup"></script> <script src="/themes/alnylam/js/script.js?sjarup"></script> <script src="/themes/alnylam/js/to_maintain.js?sjarup"></script> <script src="/themes/bootstrap/js/drupal.bootstrap.js?sjarup"></script> <script src="/themes/bootstrap/js/attributes.js?sjarup"></script> <script src="/themes/bootstrap/js/theme.js?sjarup"></script> <script src="/themes/bootstrap/js/popover.js?sjarup"></script> <script src="/core/misc/progress.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/progress.js?sjarup"></script> <script src="/core/misc/jquery.once.bc.js?v=9.5.5"></script> <script src="/core/assets/vendor/loadjs/loadjs.min.js?v=4.2.0"></script> <script src="/core/misc/ajax.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/ajax.js?sjarup"></script> <script src="/core/misc/displace.js?v=9.5.5"></script> <script src="/core/misc/jquery.tabbable.shim.js?v=9.5.5"></script> <script src="/core/misc/position.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/modal.js?sjarup"></script> <script src="/themes/bootstrap/js/dialog.js?sjarup"></script> <script src="/themes/bootstrap/js/modal.jquery.ui.bridge.js?sjarup"></script> <script src="/core/misc/dialog/dialog.js?v=9.5.5"></script> <script src="/core/misc/dialog/dialog.position.js?v=9.5.5"></script> <script src="/core/misc/dialog/dialog.ajax.js?v=9.5.5"></script> <script src="/themes/bootstrap/js/misc/dialog.ajax.js?sjarup"></script> </body> </html>