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(PDF) Skeletal Muscle Capillarity during Hypoxia: VEGF and Its Activation
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{"work":{"id":19477386,"created_at":"2015-12-04T12:10:34.179-08:00","from_world_paper_id":145616437,"updated_at":"2025-01-12T01:36:42.378-08:00","_data":{"ai_abstract":"This review explores the regulation of vascular endothelial growth factor (VEGF) in skeletal muscle during hypoxic conditions, primarily focusing on the role of hypoxia-inducible factor (HIF-1␣) and other pathways that might influence VEGF expression. Long-standing beliefs that VEGF expression is predominantly driven by hypoxia are challenged, suggesting a more complex interplay of various signals including inflammation and cellular energy status. Understanding these mechanisms could have implications for conditions such as chronic obstructive pulmonary disease (COPD) and for individuals exposed to high altitudes.","publication_date":"2008,,","publication_name":"High Altitude Medicine \u0026 Biology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Skeletal Muscle Capillarity during Hypoxia: VEGF and Its Activation","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [39751345]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card ds-work-card--no-bottom-spacing"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":40642128,"attachmentType":"pdf"}"><img alt="First page of “Skeletal Muscle Capillarity during Hypoxia: VEGF and Its Activation”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/40642128/mini_magick20190220-28704-1rc4m18.png?1550709549" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Skeletal Muscle Capillarity during Hypoxia: VEGF and Its Activation</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="39751345" href="https://ucsd.academia.edu/EllenBreen"><img alt="Profile image of Ellen Breen" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Ellen Breen</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2008, High Altitude Medicine & Biology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">9 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 19477386; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=19477386"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--detail ds2-5-body-md">AI-generated Abstract</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">This review explores the regulation of vascular endothelial growth factor (VEGF) in skeletal muscle during hypoxic conditions, primarily focusing on the role of hypoxia-inducible factor (HIF-1␣) and other pathways that might influence VEGF expression. Long-standing beliefs that VEGF expression is predominantly driven by hypoxia are challenged, suggesting a more complex interplay of various signals including inflammation and cellular energy status. 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5371749" href="https://unibe-ch.academia.edu/UrbanDeutsch">Urban Deutsch</a></div><p class="ds-related-work--metadata ds2-5-body-xs">FEBS Letters, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability","attachmentId":42295080,"attachmentType":"pdf","work_url":"https://www.academia.edu/17192426/Hypoxic_induction_of_vascular_endothelial_growth_factor_VEGF_in_human_epithelial_cells_is_mediated_by_increases_in_mRNA_stability","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a 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href="https://independent.academia.edu/wegrzynjoanna">joanna wegrzyn</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1","attachmentId":72622569,"attachmentType":"pdf","work_url":"https://www.academia.edu/57995928/Opposite_effects_of_prostaglandin_J2_on_VEGF_in_normoxia_and_hypoxia_role_of_HIF_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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href="https://independent.academia.edu/KeithLaderoute">Keith Laderoute</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression","attachmentId":71934702,"attachmentType":"pdf","work_url":"https://www.academia.edu/56655698/Oncogenic_transformation_and_hypoxia_synergistically_act_to_modulate_vascular_endothelial_growth_factor_expression","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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ds2-5-body-xs">Circulation, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interindividual Heterogeneity in the Hypoxic Regulation of VEGF","attachmentId":87486177,"attachmentType":"pdf","work_url":"https://www.academia.edu/81445392/Interindividual_Heterogeneity_in_the_Hypoxic_Regulation_of_VEGF","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/81445392/Interindividual_Heterogeneity_in_the_Hypoxic_Regulation_of_VEGF"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" 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