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class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Therapeutic horse riding is often employed for disabled children. The aim of the present paper was to determine the influence of exercise in a mechanical saddle, imitating horse&#39;s walk, on the skin temperature responses in lower limbs... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_69578121" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Therapeutic horse riding is often employed for disabled children. The aim of the present paper was to determine the influence of exercise in a mechanical saddle, imitating horse&#39;s walk, on the skin temperature responses in lower limbs in children with cerebral palsy. Sixteen children, aged 14-16, were enrolled into the study. Skin surface temperature was assessed with thermography, using an infrared thermovision camera, AGEMA 550, before and directly after 20 +/-5 min of exercise. The findings demonstrate that mechanical hippotherapy provides an exercise stimulus that is capable of inducing a visible change in skin temperature of paralyzed limbs. The change, however, is one of a decrease in skin temperature, which points to acute vasoconstrictive effects of exercise and to decreased skin blood flow. The results, therefore, do not support the use of mechanical hippotherapy in children suffering from cerebral palsy, with a hope to stimulate blood circulation to spastically altered...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/69578121" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d3aa76f319776ef892ff4e0a999d1ec0" rel="nofollow" data-download="{"attachment_id":79620400,"asset_id":69578121,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/79620400/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="186141888" href="https://independent.academia.edu/KrzysztofDudek7">Krzysztof Dudek</a><script data-card-contents-for-user="186141888" type="text/json">{"id":186141888,"first_name":"Krzysztof","last_name":"Dudek","domain_name":"independent","page_name":"KrzysztofDudek7","display_name":"Krzysztof Dudek","profile_url":"https://independent.academia.edu/KrzysztofDudek7?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_69578121 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="69578121"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 69578121, container: ".js-paper-rank-work_69578121", }); 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The aim of the present paper was to determine the influence of exercise in a mechanical saddle, imitating horse\u0026#39;s walk, on the skin temperature responses in lower limbs in children with cerebral palsy. Sixteen children, aged 14-16, were enrolled into the study. Skin surface temperature was assessed with thermography, using an infrared thermovision camera, AGEMA 550, before and directly after 20 +/-5 min of exercise. The findings demonstrate that mechanical hippotherapy provides an exercise stimulus that is capable of inducing a visible change in skin temperature of paralyzed limbs. The change, however, is one of a decrease in skin temperature, which points to acute vasoconstrictive effects of exercise and to decreased skin blood flow. The results, therefore, do not support the use of mechanical hippotherapy in children suffering from cerebral palsy, with a hope to stimulate blood circulation to spastically altered...","downloadable_attachments":[{"id":79620400,"asset_id":69578121,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":186141888,"first_name":"Krzysztof","last_name":"Dudek","domain_name":"independent","page_name":"KrzysztofDudek7","display_name":"Krzysztof Dudek","profile_url":"https://independent.academia.edu/KrzysztofDudek7?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":15635,"name":"Thermography","url":"https://www.academia.edu/Documents/in/Thermography?f_ri=186234","nofollow":false},{"id":17845,"name":"Cerebral 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href="https://www.academia.edu/10676971/The_calcium_sensing_receptor_a_key_factor_in_the_pathogenesis_of_secondary_hyperparathyroidism">The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10676971" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="61c5ea7d5e58310c72d37bee16b03d9b" rel="nofollow" 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diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a>, <script data-card-contents-for-ri="9534" type="text/json">{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=10676971]'), work: {"id":10676971,"title":"The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism","created_at":"2015-02-10T07:58:55.786-08:00","url":"https://www.academia.edu/10676971/The_calcium_sensing_receptor_a_key_factor_in_the_pathogenesis_of_secondary_hyperparathyroidism?f_ri=186234","dom_id":"work_10676971","summary":null,"downloadable_attachments":[{"id":47211897,"asset_id":10676971,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26067230,"first_name":"Mariano","last_name":"Rodriguez","domain_name":"independent","page_name":"MarianoRodriguez4","display_name":"Mariano Rodriguez","profile_url":"https://independent.academia.edu/MarianoRodriguez4?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":8999,"name":"Kidney diseases","url":"https://www.academia.edu/Documents/in/Kidney_diseases?f_ri=186234","nofollow":false},{"id":9534,"name":"Calcium","url":"https://www.academia.edu/Documents/in/Calcium?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=186234"},{"id":146046,"name":"Calcium Sensing Receptor","url":"https://www.academia.edu/Documents/in/Calcium_Sensing_Receptor?f_ri=186234"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":379889,"name":"Homeostasis","url":"https://www.academia.edu/Documents/in/Homeostasis?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45216415" data-work_id="45216415" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45216415/A_multiscale_model_of_mechanotransduction_by_the_ankyrin_chains_of_the_NOMPC_channel">A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Our senses of touch and hearing are dependent on the conversion of external mechanical forces into electrical impulses by the opening of mechanosensitive channels in sensory cells. This remarkable feat involves the conversion of a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_45216415" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Our senses of touch and hearing are dependent on the conversion of external mechanical forces into electrical impulses by the opening of mechanosensitive channels in sensory cells. This remarkable feat involves the conversion of a macroscopic mechanical displacement into a subnanoscopic conformational change within the ion channel. The mechanosensitive channel NOMPC, responsible for hearing and touch in flies, is a homotetramer composed of four pore-forming transmembrane domains and four helical chains of 29 ankyrin repeats that extend 150 Å into the cytoplasm. Previous work has shown that the ankyrin chains behave as biological springs under extension and that tethering them to microtubules could be involved in the transmission of external forces to the NOMPC gate. Here we combine normal mode analysis (NMA), full-atom molecular dynamics simulations, and continuum mechanics to characterize the material properties of the chains under extreme compression and extension. NMA reveals tha...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45216415" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a770fdd9209caa2805526021a102517d" rel="nofollow" data-download="{"attachment_id":65795962,"asset_id":45216415,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/65795962/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3039660" href="https://upenn.academia.edu/DavidArgudo">David Argudo</a><script data-card-contents-for-user="3039660" type="text/json">{"id":3039660,"first_name":"David","last_name":"Argudo","domain_name":"upenn","page_name":"DavidArgudo","display_name":"David Argudo","profile_url":"https://upenn.academia.edu/DavidArgudo?f_ri=186234","photo":"https://0.academia-photos.com/3039660/1918531/2272368/s65_david.argudo.jpg"}</script></span></span></li><li class="js-paper-rank-work_45216415 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="45216415"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 45216415, container: ".js-paper-rank-work_45216415", }); 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$(".js-view-count[data-work-id=45216415]").text(description); $(".js-view-count-work_45216415").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_45216415").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="45216415"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="167" href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="186234" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a>, <script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1439670" href="https://www.academia.edu/Documents/in/General_Physiology">General Physiology</a><script data-card-contents-for-ri="1439670" type="text/json">{"id":1439670,"name":"General Physiology","url":"https://www.academia.edu/Documents/in/General_Physiology?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=45216415]'), work: {"id":45216415,"title":"A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel","created_at":"2021-02-26T13:30:26.885-08:00","url":"https://www.academia.edu/45216415/A_multiscale_model_of_mechanotransduction_by_the_ankyrin_chains_of_the_NOMPC_channel?f_ri=186234","dom_id":"work_45216415","summary":"Our senses of touch and hearing are dependent on the conversion of external mechanical forces into electrical impulses by the opening of mechanosensitive channels in sensory cells. This remarkable feat involves the conversion of a macroscopic mechanical displacement into a subnanoscopic conformational change within the ion channel. The mechanosensitive channel NOMPC, responsible for hearing and touch in flies, is a homotetramer composed of four pore-forming transmembrane domains and four helical chains of 29 ankyrin repeats that extend 150 Å into the cytoplasm. Previous work has shown that the ankyrin chains behave as biological springs under extension and that tethering them to microtubules could be involved in the transmission of external forces to the NOMPC gate. Here we combine normal mode analysis (NMA), full-atom molecular dynamics simulations, and continuum mechanics to characterize the material properties of the chains under extreme compression and extension. NMA reveals tha...","downloadable_attachments":[{"id":65795962,"asset_id":45216415,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3039660,"first_name":"David","last_name":"Argudo","domain_name":"upenn","page_name":"DavidArgudo","display_name":"David Argudo","profile_url":"https://upenn.academia.edu/DavidArgudo?f_ri=186234","photo":"https://0.academia-photos.com/3039660/1918531/2272368/s65_david.argudo.jpg"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false},{"id":1439670,"name":"General Physiology","url":"https://www.academia.edu/Documents/in/General_Physiology?f_ri=186234","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_56623934" data-work_id="56623934" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/56623934/The_apical_hPepT1_and_basolateral_peptide_transport_systems_of_Caco_2_cells_are_regulated_by_AMP_activated_protein_kinase">The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [3H]-D-Phe-L-Gln was investigated in the human epithelial colon... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_56623934" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) activation of the AMP-activated protein kinase (AMPK) on the transport of the model radiolabeled dipeptide [3H]-D-Phe-L-Gln was investigated in the human epithelial colon cancer cell line Caco-2. Uptake and transepithelial fluxes of [3H]-D-Phe-L-Gln were carried out in differentiated Caco-2 cell monolayers, and hPepT1 and glucose transporter 2 (GLUT2) protein levels were quantified by immunogold electron microscopy. AICAR treatment of Caco-2 cells significantly inhibited apical [3H]-D-Phe-L-Gln uptake, matched by a decrease in brush-border membrane hPepT1 protein but with a concomitant increase in the facilitated glucose transporter GLUT2. A restructuring of the apical brush-border membrane was seen by electron microscopy. The hPepT1-mediated transepithelial (A-to-B) peptide flux across the Caco-2 monolayers showed no significant alteration in AICAR-treated cells. The electrical resistance in the AICAR-treated monol...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/56623934" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0357815a8bca2d0d1a1b6932b391665b" rel="nofollow" data-download="{"attachment_id":71919947,"asset_id":56623934,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71919947/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42324845" href="https://oxford.academia.edu/RichardBoyd">Richard Boyd</a><script data-card-contents-for-user="42324845" type="text/json">{"id":42324845,"first_name":"Richard","last_name":"Boyd","domain_name":"oxford","page_name":"RichardBoyd","display_name":"Richard Boyd","profile_url":"https://oxford.academia.edu/RichardBoyd?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_56623934 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="56623934"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 56623934, container: ".js-paper-rank-work_56623934", }); 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Uptake and transepithelial fluxes of [3H]-D-Phe-L-Gln were carried out in differentiated Caco-2 cell monolayers, and hPepT1 and glucose transporter 2 (GLUT2) protein levels were quantified by immunogold electron microscopy. AICAR treatment of Caco-2 cells significantly inhibited apical [3H]-D-Phe-L-Gln uptake, matched by a decrease in brush-border membrane hPepT1 protein but with a concomitant increase in the facilitated glucose transporter GLUT2. A restructuring of the apical brush-border membrane was seen by electron microscopy. The hPepT1-mediated transepithelial (A-to-B) peptide flux across the Caco-2 monolayers showed no significant alteration in AICAR-treated cells. The electrical resistance in the AICAR-treated monol...","downloadable_attachments":[{"id":71919947,"asset_id":56623934,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42324845,"first_name":"Richard","last_name":"Boyd","domain_name":"oxford","page_name":"RichardBoyd","display_name":"Richard Boyd","profile_url":"https://oxford.academia.edu/RichardBoyd?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=186234","nofollow":false},{"id":14079,"name":"Scanning Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Scanning_Transmission_Electron_Microscopy?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":71471,"name":"Intestinal Mucosa","url":"https://www.academia.edu/Documents/in/Intestinal_Mucosa?f_ri=186234"},{"id":115896,"name":"Membrane transport","url":"https://www.academia.edu/Documents/in/Membrane_transport?f_ri=186234"},{"id":122569,"name":"Cell Polarity","url":"https://www.academia.edu/Documents/in/Cell_Polarity?f_ri=186234"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":314125,"name":"Caco-2 cells","url":"https://www.academia.edu/Documents/in/Caco-2_cells?f_ri=186234"},{"id":336223,"name":"Digestive System","url":"https://www.academia.edu/Documents/in/Digestive_System?f_ri=186234"},{"id":379416,"name":"Epithelial cells","url":"https://www.academia.edu/Documents/in/Epithelial_cells?f_ri=186234"},{"id":499747,"name":"Cell Shape","url":"https://www.academia.edu/Documents/in/Cell_Shape?f_ri=186234"},{"id":801416,"name":"Guanidines","url":"https://www.academia.edu/Documents/in/Guanidines?f_ri=186234"},{"id":1015261,"name":"Ribonucleotides","url":"https://www.academia.edu/Documents/in/Ribonucleotides?f_ri=186234"},{"id":1137254,"name":"Hydrogen-Ion Concentration","url":"https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration?f_ri=186234"},{"id":1232950,"name":"Fluorometry","url":"https://www.academia.edu/Documents/in/Fluorometry?f_ri=186234"},{"id":1272890,"name":"Electric Impedance","url":"https://www.academia.edu/Documents/in/Electric_Impedance?f_ri=186234"},{"id":2756775,"name":"transport system","url":"https://www.academia.edu/Documents/in/transport_system?f_ri=186234"},{"id":4045205,"name":"Methacrylates","url":"https://www.academia.edu/Documents/in/Methacrylates?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_20324478" data-work_id="20324478" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/20324478/Dielectric_properties_of_blood_an_investigation_of_haematocrit_dependence">Dielectric properties of blood: an investigation of haematocrit dependence</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/20324478" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1df6e6113871d5f6045493fcea316855" rel="nofollow" data-download="{"attachment_id":41285159,"asset_id":20324478,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41285159/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="41607379" href="https://independent.academia.edu/ARouane">A. 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spontaneous conventional recordings?</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Perforated whole-cell patch-clamp recordings obtained with nystatin are frequently used to preserve intracellular integrity. However, the perforated-patch configuration may sometimes undergo a spontaneous change into the conventional... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_17918074" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Perforated whole-cell patch-clamp recordings obtained with nystatin are frequently used to preserve intracellular integrity. However, the perforated-patch configuration may sometimes undergo a spontaneous change into the conventional whole-cell configuration, especially when lymphocytes are investigated. The electrophysiological criteria-- previously described--for establishing the existence of the perforated whole-cell configuration have been shown to be insufficient. Thus, the dye eosin, applied to the pipette solution, was tested as a tool for discriminating between the perforated and the conventional whole-cell configurations on rat T-lymphocytes. The dye never entered the cell from the pipette during the entire measurement in the perforated whole-cell configuration. In contrast, all cells in the conventional whole-cell configuration became red immediately after membrane rupture. Eosin barely changed the currents studied. The results suggest that eosin is a dye of choice for verifying a true perforated-patch configuration.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/17918074" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a2bf479cc824fcaddea99a04713db22d" rel="nofollow" data-download="{"attachment_id":42217946,"asset_id":17918074,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42217946/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="37834596" href="https://independent.academia.edu/UlfStrauss">Ulf Strauss</a><script data-card-contents-for-user="37834596" type="text/json">{"id":37834596,"first_name":"Ulf","last_name":"Strauss","domain_name":"independent","page_name":"UlfStrauss","display_name":"Ulf Strauss","profile_url":"https://independent.academia.edu/UlfStrauss?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_17918074 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="17918074"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 17918074, container: ".js-paper-rank-work_17918074", }); 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However, the perforated-patch configuration may sometimes undergo a spontaneous change into the conventional whole-cell configuration, especially when lymphocytes are investigated. The electrophysiological criteria-- previously described--for establishing the existence of the perforated whole-cell configuration have been shown to be insufficient. Thus, the dye eosin, applied to the pipette solution, was tested as a tool for discriminating between the perforated and the conventional whole-cell configurations on rat T-lymphocytes. The dye never entered the cell from the pipette during the entire measurement in the perforated whole-cell configuration. In contrast, all cells in the conventional whole-cell configuration became red immediately after membrane rupture. Eosin barely changed the currents studied. 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u-tcGrayDark u-linkUnstyled" data-container=".work_9014404" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">This study examines the relationship between a computerized neuropsychological assessment battery, the Automated Neuropsychological Assessment Metrics (ANAM) and a widely used ability measure, Woodcock-Johnson III Tests of Cognitive Ability (WJ-III). Results indicated substantial relationship between the ANAM throughput (accuracy/response time) scores and the WJ-III Cognitive Efficiency cluster. An unexpectedly strong relationship was evident between accuracy scores on the ANAM Logical Reasoning scale and the WJ-III General Intellectual Ability score, purporting to measure the g factor. The findings support the viability of the ANAM as a time- and cost-effective tool for appraisal of cognitive function.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9014404" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="154b5337e3111b4a12e1809fec0e755c" rel="nofollow" data-download="{"attachment_id":47914900,"asset_id":9014404,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47914900/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="20271185" href="https://unlv.academia.edu/SKathleenKrach">S. 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polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61430544" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Signalling interactions between the polarizing region, which produces SHH, and the apical ectodermal ridge, which produces FGFs, are essential for outgrowth and patterning of vertebrate limbs. However, mechanisms that mediate translation of early positional information of cells into ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61430544" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="889734fd689af789a136b452dff2d20c" rel="nofollow" data-download="{"attachment_id":74461967,"asset_id":61430544,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74461967/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44225144" href="https://independent.academia.edu/JuanjoSanzEzquerro">Juanjo Sanz Ezquerro</a><script data-card-contents-for-user="44225144" type="text/json">{"id":44225144,"first_name":"Juanjo","last_name":"Sanz Ezquerro","domain_name":"independent","page_name":"JuanjoSanzEzquerro","display_name":"Juanjo Sanz Ezquerro","profile_url":"https://independent.academia.edu/JuanjoSanzEzquerro?f_ri=186234","photo":"https://0.academia-photos.com/44225144/78995989/67555456/s65_juanjo.sanz_ezquerro.png"}</script></span></span></li><li class="js-paper-rank-work_61430544 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61430544"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61430544, container: ".js-paper-rank-work_61430544", }); 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However, mechanisms that mediate translation of early positional information of cells into ...","downloadable_attachments":[{"id":74461967,"asset_id":61430544,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44225144,"first_name":"Juanjo","last_name":"Sanz Ezquerro","domain_name":"independent","page_name":"JuanjoSanzEzquerro","display_name":"Juanjo Sanz Ezquerro","profile_url":"https://independent.academia.edu/JuanjoSanzEzquerro?f_ri=186234","photo":"https://0.academia-photos.com/44225144/78995989/67555456/s65_juanjo.sanz_ezquerro.png"}],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering?f_ri=186234","nofollow":false},{"id":24124,"name":"Morphogenesis","url":"https://www.academia.edu/Documents/in/Morphogenesis?f_ri=186234","nofollow":false},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=186234","nofollow":false},{"id":43160,"name":"Embryo","url":"https://www.academia.edu/Documents/in/Embryo?f_ri=186234","nofollow":false},{"id":54589,"name":"Anatomy","url":"https://www.academia.edu/Documents/in/Anatomy?f_ri=186234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":534656,"name":"Joint","url":"https://www.academia.edu/Documents/in/Joint?f_ri=186234"},{"id":670043,"name":"Joints","url":"https://www.academia.edu/Documents/in/Joints?f_ri=186234"},{"id":2197154,"name":"Extremities","url":"https://www.academia.edu/Documents/in/Extremities?f_ri=186234"},{"id":3675689,"name":"Chick embryo","url":"https://www.academia.edu/Documents/in/Chick_embryo?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_15182118" data-work_id="15182118" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/15182118/Onset_related_differences_in_neural_substrates_of_tinnitus_related_distress_the_anterior_cingulate_cortex_in_late_onset_tinnitus_and_the_frontal_cortex_in_early_onset_tinnitus">Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_15182118" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD-LOT participants than in LD-LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dors...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/15182118" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="15cd487e36e7d0ab1d0eeb2510c969ac" rel="nofollow" data-download="{"attachment_id":43490382,"asset_id":15182118,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43490382/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34239583" href="https://independent.academia.edu/SvenVanneste">Sven Vanneste</a><script data-card-contents-for-user="34239583" type="text/json">{"id":34239583,"first_name":"Sven","last_name":"Vanneste","domain_name":"independent","page_name":"SvenVanneste","display_name":"Sven Vanneste","profile_url":"https://independent.academia.edu/SvenVanneste?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_15182118 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="15182118"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 15182118, container: ".js-paper-rank-work_15182118", }); 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$(".js-view-count[data-work-id=15182118]").text(description); $(".js-view-count-work_15182118").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_15182118").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="15182118"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5069" href="https://www.academia.edu/Documents/in/Principal_Component_Analysis">Principal Component Analysis</a>, <script data-card-contents-for-ri="5069" type="text/json">{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10904" href="https://www.academia.edu/Documents/in/Electroencephalography">Electroencephalography</a>, <script data-card-contents-for-ri="10904" type="text/json">{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="28576" href="https://www.academia.edu/Documents/in/Prefrontal_Cortex">Prefrontal Cortex</a><script data-card-contents-for-ri="28576" type="text/json">{"id":28576,"name":"Prefrontal Cortex","url":"https://www.academia.edu/Documents/in/Prefrontal_Cortex?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=15182118]'), work: {"id":15182118,"title":"Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus","created_at":"2015-08-25T20:45:50.032-07:00","url":"https://www.academia.edu/15182118/Onset_related_differences_in_neural_substrates_of_tinnitus_related_distress_the_anterior_cingulate_cortex_in_late_onset_tinnitus_and_the_frontal_cortex_in_early_onset_tinnitus?f_ri=186234","dom_id":"work_15182118","summary":"Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD-LOT participants than in LD-LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dors...","downloadable_attachments":[{"id":43490382,"asset_id":15182118,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34239583,"first_name":"Sven","last_name":"Vanneste","domain_name":"independent","page_name":"SvenVanneste","display_name":"Sven Vanneste","profile_url":"https://independent.academia.edu/SvenVanneste?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=186234","nofollow":false},{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=186234","nofollow":false},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=186234","nofollow":false},{"id":28576,"name":"Prefrontal Cortex","url":"https://www.academia.edu/Documents/in/Prefrontal_Cortex?f_ri=186234","nofollow":false},{"id":52176,"name":"Brain Mapping","url":"https://www.academia.edu/Documents/in/Brain_Mapping?f_ri=186234"},{"id":61516,"name":"Evoked Potentials","url":"https://www.academia.edu/Documents/in/Evoked_Potentials?f_ri=186234"},{"id":62841,"name":"Tinnitus","url":"https://www.academia.edu/Documents/in/Tinnitus?f_ri=186234"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=186234"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=186234"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=186234"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=186234"},{"id":1489115,"name":"Age of Onset","url":"https://www.academia.edu/Documents/in/Age_of_Onset?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16690936" data-work_id="16690936" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16690936/Immunohistochemical_localization_of_facilitated_diffusion_glucose_transporters_in_rat_pancreatic_islets">Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The subcellular localization of five isoforms of facilitated-diffusion glucose transporters (GLUTs), from GLUT1 to GLUT5, in rat pancreatic islets was studied by immunohistochemistry using rabbit polyclonal antisera against mouse or rat... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16690936" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The subcellular localization of five isoforms of facilitated-diffusion glucose transporters (GLUTs), from GLUT1 to GLUT5, in rat pancreatic islets was studied by immunohistochemistry using rabbit polyclonal antisera against mouse or rat GLUT peptides. Animals were perfusion-fixed with phosphate-buffered 4% paraformaldehyde and the pancreases were removed. Some specimens were embedded in paraffin, serially sectioned, and immunostained for glucagon, insulin, somatostatin, and the GLUTs for light microscopic observation. Others were prepared for immunoelectron microscopy by the post-embedding method. By these methods, GLUT2 immunostaining was observed on the lateral membranes of pancreatic beta-cells, whereas GLUT3 immunoreaction was predominantly localized in the cytoplasm of beta-cells and was not found in alpha-cells. In contrast, GLUT5 immunostaining was preferentially localized in the cytoplasm of alpha-cells compared to that of beta-cells. However, GLUT1 and GLUT4 were either barely or not at all detectable in any cells. These results suggest that rat islets take up glucose by at least three different processes and that blood glucose levels could be modulated differentially by: a high Km glucose transporter, GLUT2, in beta-cells; by a low Km glucose transporter, GLUT3, in beta-cells; and by a low Km glucose transporter, GLUT5, in alpha-cells.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16690936" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="574ce425d403cba4fd91ea193e60363b" rel="nofollow" data-download="{"attachment_id":42415420,"asset_id":16690936,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42415420/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36070066" href="https://independent.academia.edu/TIto7">T. Ito</a><script data-card-contents-for-user="36070066" type="text/json">{"id":36070066,"first_name":"T.","last_name":"Ito","domain_name":"independent","page_name":"TIto7","display_name":"T. Ito","profile_url":"https://independent.academia.edu/TIto7?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16690936 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16690936"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16690936, container: ".js-paper-rank-work_16690936", }); });</script></li><li class="js-percentile-work_16690936 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16690936; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16690936"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16690936 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16690936"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16690936; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16690936]").text(description); $(".js-view-count-work_16690936").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16690936").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="16690936"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="12071" href="https://www.academia.edu/Documents/in/Immunohistochemistry">Immunohistochemistry</a>, <script data-card-contents-for-ri="12071" type="text/json">{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62660" href="https://www.academia.edu/Documents/in/Cell_and_Tissue_Transplantation">Cell and Tissue Transplantation</a>, <script data-card-contents-for-ri="62660" type="text/json">{"id":62660,"name":"Cell and Tissue Transplantation","url":"https://www.academia.edu/Documents/in/Cell_and_Tissue_Transplantation?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71300" href="https://www.academia.edu/Documents/in/Blood_Glucose">Blood Glucose</a>, <script data-card-contents-for-ri="71300" type="text/json">{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71400" href="https://www.academia.edu/Documents/in/Insulin">Insulin</a><script data-card-contents-for-ri="71400" type="text/json">{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=16690936]'), work: {"id":16690936,"title":"Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets","created_at":"2015-10-12T04:44:29.804-07:00","url":"https://www.academia.edu/16690936/Immunohistochemical_localization_of_facilitated_diffusion_glucose_transporters_in_rat_pancreatic_islets?f_ri=186234","dom_id":"work_16690936","summary":"The subcellular localization of five isoforms of facilitated-diffusion glucose transporters (GLUTs), from GLUT1 to GLUT5, in rat pancreatic islets was studied by immunohistochemistry using rabbit polyclonal antisera against mouse or rat GLUT peptides. Animals were perfusion-fixed with phosphate-buffered 4% paraformaldehyde and the pancreases were removed. Some specimens were embedded in paraffin, serially sectioned, and immunostained for glucagon, insulin, somatostatin, and the GLUTs for light microscopic observation. Others were prepared for immunoelectron microscopy by the post-embedding method. By these methods, GLUT2 immunostaining was observed on the lateral membranes of pancreatic beta-cells, whereas GLUT3 immunoreaction was predominantly localized in the cytoplasm of beta-cells and was not found in alpha-cells. In contrast, GLUT5 immunostaining was preferentially localized in the cytoplasm of alpha-cells compared to that of beta-cells. However, GLUT1 and GLUT4 were either barely or not at all detectable in any cells. These results suggest that rat islets take up glucose by at least three different processes and that blood glucose levels could be modulated differentially by: a high Km glucose transporter, GLUT2, in beta-cells; by a low Km glucose transporter, GLUT3, in beta-cells; and by a low Km glucose transporter, GLUT5, in alpha-cells.","downloadable_attachments":[{"id":42415420,"asset_id":16690936,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36070066,"first_name":"T.","last_name":"Ito","domain_name":"independent","page_name":"TIto7","display_name":"T. Ito","profile_url":"https://independent.academia.edu/TIto7?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=186234","nofollow":false},{"id":62660,"name":"Cell and Tissue Transplantation","url":"https://www.academia.edu/Documents/in/Cell_and_Tissue_Transplantation?f_ri=186234","nofollow":false},{"id":71300,"name":"Blood Glucose","url":"https://www.academia.edu/Documents/in/Blood_Glucose?f_ri=186234","nofollow":false},{"id":71400,"name":"Insulin","url":"https://www.academia.edu/Documents/in/Insulin?f_ri=186234","nofollow":false},{"id":71402,"name":"Glucagon","url":"https://www.academia.edu/Documents/in/Glucagon?f_ri=186234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=186234"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":240853,"name":"Subcellular Localization","url":"https://www.academia.edu/Documents/in/Subcellular_Localization?f_ri=186234"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats?f_ri=186234"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=186234"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=186234"},{"id":1705044,"name":"islets of Langerhans","url":"https://www.academia.edu/Documents/in/islets_of_Langerhans?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_80220330" data-work_id="80220330" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/80220330/Therapeutic_effect_of_lecithinized_superoxide_dismutase_on_bleomycin_induced_pulmonary_fibrosis">Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species (ROS), in particular superoxide anion, and fibrosis (collagen deposition). No treatment has... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_80220330" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species (ROS), in particular superoxide anion, and fibrosis (collagen deposition). No treatment has been shown to improve definitively the prognosis for IPF patients. Superoxide dismutase (SOD) catalyzes the dismutation of superoxide anion to hydrogen peroxide, which is subsequently detoxified by catalase. Lecithinized SOD (PC-SOD) has overcome clinical limitations of SOD, including low tissue affinity and low stability in plasma. In this study, we examined the effect of PC-SOD on bleomycin-induced pulmonary fibrosis. Severity of the bleomycin-induced fibrosis in mice was assessed by various methods, including determination of hydroxyproline levels in lung tissue. Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and incr...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/80220330" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="767b51ca4dfb1bb56e68efd0e110e0f7" rel="nofollow" data-download="{"attachment_id":86674597,"asset_id":80220330,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86674597/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="47000873" href="https://independent.academia.edu/MitsukoTakenaga">Mitsuko Takenaga</a><script data-card-contents-for-user="47000873" type="text/json">{"id":47000873,"first_name":"Mitsuko","last_name":"Takenaga","domain_name":"independent","page_name":"MitsukoTakenaga","display_name":"Mitsuko Takenaga","profile_url":"https://independent.academia.edu/MitsukoTakenaga?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_80220330 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="80220330"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 80220330, container: ".js-paper-rank-work_80220330", }); });</script></li><li class="js-percentile-work_80220330 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 80220330; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_80220330"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_80220330 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="80220330"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 80220330; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=80220330]").text(description); $(".js-view-count-work_80220330").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_80220330").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="80220330"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="167" href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71308" href="https://www.academia.edu/Documents/in/Pulmonary_fibrosis">Pulmonary fibrosis</a><script data-card-contents-for-ri="71308" type="text/json">{"id":71308,"name":"Pulmonary fibrosis","url":"https://www.academia.edu/Documents/in/Pulmonary_fibrosis?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=80220330]'), work: {"id":80220330,"title":"Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis","created_at":"2022-05-29T17:24:02.002-07:00","url":"https://www.academia.edu/80220330/Therapeutic_effect_of_lecithinized_superoxide_dismutase_on_bleomycin_induced_pulmonary_fibrosis?f_ri=186234","dom_id":"work_80220330","summary":"Idiopathic pulmonary fibrosis (IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species (ROS), in particular superoxide anion, and fibrosis (collagen deposition). No treatment has been shown to improve definitively the prognosis for IPF patients. Superoxide dismutase (SOD) catalyzes the dismutation of superoxide anion to hydrogen peroxide, which is subsequently detoxified by catalase. Lecithinized SOD (PC-SOD) has overcome clinical limitations of SOD, including low tissue affinity and low stability in plasma. In this study, we examined the effect of PC-SOD on bleomycin-induced pulmonary fibrosis. Severity of the bleomycin-induced fibrosis in mice was assessed by various methods, including determination of hydroxyproline levels in lung tissue. Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and incr...","downloadable_attachments":[{"id":86674597,"asset_id":80220330,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":47000873,"first_name":"Mitsuko","last_name":"Takenaga","domain_name":"independent","page_name":"MitsukoTakenaga","display_name":"Mitsuko Takenaga","profile_url":"https://independent.academia.edu/MitsukoTakenaga?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=186234","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false},{"id":71308,"name":"Pulmonary fibrosis","url":"https://www.academia.edu/Documents/in/Pulmonary_fibrosis?f_ri=186234","nofollow":false},{"id":79808,"name":"Collagen","url":"https://www.academia.edu/Documents/in/Collagen?f_ri=186234"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=186234"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=186234"},{"id":111112,"name":"Pneumonia","url":"https://www.academia.edu/Documents/in/Pneumonia?f_ri=186234"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=186234"},{"id":139007,"name":"Catalase","url":"https://www.academia.edu/Documents/in/Catalase?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=186234"},{"id":213343,"name":"Superoxide Dismutase","url":"https://www.academia.edu/Documents/in/Superoxide_Dismutase?f_ri=186234"},{"id":274826,"name":"Hydrogen Peroxide","url":"https://www.academia.edu/Documents/in/Hydrogen_Peroxide?f_ri=186234"},{"id":376494,"name":"Epithelium","url":"https://www.academia.edu/Documents/in/Epithelium?f_ri=186234"},{"id":695493,"name":"Bleomycin","url":"https://www.academia.edu/Documents/in/Bleomycin?f_ri=186234"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79548710" data-work_id="79548710" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79548710/Effects_of_reduced_muscle_temperature_on_the_oxygen_uptake_kinetics_at_the_start_of_exercise">Effects of reduced muscle temperature on the oxygen uptake kinetics at the start of exercise</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79548710" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="38ab7415c4e827a4941115a32da3ac43" rel="nofollow" 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}); });</script></span><script>$(function() { $(".js-view-count-work_79548710").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79548710"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="4987" href="https://www.academia.edu/Documents/in/Kinetics">Kinetics</a>, <script data-card-contents-for-ri="4987" type="text/json">{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="74347" href="https://www.academia.edu/Documents/in/Hemodynamics">Hemodynamics</a>, <script data-card-contents-for-ri="74347" type="text/json">{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="111545" href="https://www.academia.edu/Documents/in/Male">Male</a><script data-card-contents-for-ri="111545" type="text/json">{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79548710]'), work: {"id":79548710,"title":"Effects of reduced muscle temperature on the oxygen uptake kinetics at the start of exercise","created_at":"2022-05-20T17:28:09.122-07:00","url":"https://www.academia.edu/79548710/Effects_of_reduced_muscle_temperature_on_the_oxygen_uptake_kinetics_at_the_start_of_exercise?f_ri=186234","dom_id":"work_79548710","summary":null,"downloadable_attachments":[{"id":86226294,"asset_id":79548710,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":213507176,"first_name":"Manabu","last_name":"Shibasaki","domain_name":"independent","page_name":"ManabuShibasaki","display_name":"Manabu Shibasaki","profile_url":"https://independent.academia.edu/ManabuShibasaki?f_ri=186234","photo":"https://0.academia-photos.com/213507176/72377688/60841268/s65_manabu.shibasaki.png"}],"research_interests":[{"id":4987,"name":"Kinetics","url":"https://www.academia.edu/Documents/in/Kinetics?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics?f_ri=186234","nofollow":false},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234","nofollow":false},{"id":133177,"name":"Temperature","url":"https://www.academia.edu/Documents/in/Temperature?f_ri=186234"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":240716,"name":"Body Temperature","url":"https://www.academia.edu/Documents/in/Body_Temperature?f_ri=186234"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen?f_ri=186234"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=186234"},{"id":638048,"name":"Physical Exercise","url":"https://www.academia.edu/Documents/in/Physical_Exercise?f_ri=186234"},{"id":1193624,"name":"Oxygen Consumption","url":"https://www.academia.edu/Documents/in/Oxygen_Consumption?f_ri=186234"},{"id":2937977,"name":"Cardiac output","url":"https://www.academia.edu/Documents/in/Cardiac_output?f_ri=186234"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79315376" data-work_id="79315376" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79315376/Within_Subject_Reliability_and_between_Subject_Variability_of_Oxidative_Stress_Markers_in_Saliva_of_Healthy_Subjects_A_Longitudinal_Pilot_Study">Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79315376" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and uric acid (UA) were analyzed using spectrophotometric methods, while 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) were determined using immunoassays. No significant differences for salivary OS markers between men and women were observed. For all examined OS markers, no significant day-to-day variations were demonstrated. Significant diurnal variations were found in salivary GPX, TAC and MDA levels. For SOD, TAC, GPX, and UA, good-to-moderate intraindividual coefficients of variations (CVs) were observed in more than 75% of the subjects. For MDA and 8-OHdG, intraindividual CVs &gt; 35% were observed in 60% and 40% of the subjects, respectively. Bet...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79315376" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2400df98e1f6af2713475076f44dd696" rel="nofollow" data-download="{"attachment_id":86071634,"asset_id":79315376,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86071634/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="101875209" href="https://independent.academia.edu/IvanaLapi%C4%87">Ivana Lapić</a><script data-card-contents-for-user="101875209" type="text/json">{"id":101875209,"first_name":"Ivana","last_name":"Lapić","domain_name":"independent","page_name":"IvanaLapić","display_name":"Ivana Lapić","profile_url":"https://independent.academia.edu/IvanaLapi%C4%87?f_ri=186234","photo":"https://0.academia-photos.com/101875209/23574923/22621141/s65_ivana.lapi_.jpg"}</script></span></span></li><li class="js-paper-rank-work_79315376 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79315376"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79315376, container: ".js-paper-rank-work_79315376", }); });</script></li><li class="js-percentile-work_79315376 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79315376; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_79315376"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_79315376 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="79315376"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79315376; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79315376]").text(description); $(".js-view-count-work_79315376").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79315376").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79315376"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="14292" href="https://www.academia.edu/Documents/in/Oxidative_Stress">Oxidative Stress</a>, <script data-card-contents-for-ri="14292" type="text/json">{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="186234" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a>, <script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="344106" href="https://www.academia.edu/Documents/in/Saliva">Saliva</a><script data-card-contents-for-ri="344106" type="text/json">{"id":344106,"name":"Saliva","url":"https://www.academia.edu/Documents/in/Saliva?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79315376]'), work: {"id":79315376,"title":"Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study","created_at":"2022-05-17T08:31:48.431-07:00","url":"https://www.academia.edu/79315376/Within_Subject_Reliability_and_between_Subject_Variability_of_Oxidative_Stress_Markers_in_Saliva_of_Healthy_Subjects_A_Longitudinal_Pilot_Study?f_ri=186234","dom_id":"work_79315376","summary":"The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and uric acid (UA) were analyzed using spectrophotometric methods, while 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) were determined using immunoassays. No significant differences for salivary OS markers between men and women were observed. For all examined OS markers, no significant day-to-day variations were demonstrated. Significant diurnal variations were found in salivary GPX, TAC and MDA levels. For SOD, TAC, GPX, and UA, good-to-moderate intraindividual coefficients of variations (CVs) were observed in more than 75% of the subjects. For MDA and 8-OHdG, intraindividual CVs \u0026gt; 35% were observed in 60% and 40% of the subjects, respectively. Bet...","downloadable_attachments":[{"id":86071634,"asset_id":79315376,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":101875209,"first_name":"Ivana","last_name":"Lapić","domain_name":"independent","page_name":"IvanaLapić","display_name":"Ivana Lapić","profile_url":"https://independent.academia.edu/IvanaLapi%C4%87?f_ri=186234","photo":"https://0.academia-photos.com/101875209/23574923/22621141/s65_ivana.lapi_.jpg"}],"research_interests":[{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=186234","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false},{"id":344106,"name":"Saliva","url":"https://www.academia.edu/Documents/in/Saliva?f_ri=186234","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73639762" data-work_id="73639762" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73639762/Intraoperative_ventilator_settings_and_their_association_with_postoperative_pulmonary_complications_in_neurosurgical_patients_post_hoc_analysis_of_LAS_VEGAS_study">Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73639762" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0fbb04844f48b3a31f24a9d863492dc9" rel="nofollow" data-download="{"attachment_id":82082588,"asset_id":73639762,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82082588/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36353963" href="https://independent.academia.edu/MonaMomeni">Mona Momeni</a><script data-card-contents-for-user="36353963" type="text/json">{"id":36353963,"first_name":"Mona","last_name":"Momeni","domain_name":"independent","page_name":"MonaMomeni","display_name":"Mona Momeni","profile_url":"https://independent.academia.edu/MonaMomeni?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73639762 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73639762"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73639762, container: ".js-paper-rank-work_73639762", }); });</script></li><li class="js-percentile-work_73639762 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73639762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73639762"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73639762 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73639762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73639762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73639762]").text(description); $(".js-view-count-work_73639762").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73639762").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73639762"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="186234" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a><script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73639762]'), work: {"id":73639762,"title":"Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: post-hoc analysis of LAS VEGAS study","created_at":"2022-03-12T23:17:52.686-08:00","url":"https://www.academia.edu/73639762/Intraoperative_ventilator_settings_and_their_association_with_postoperative_pulmonary_complications_in_neurosurgical_patients_post_hoc_analysis_of_LAS_VEGAS_study?f_ri=186234","dom_id":"work_73639762","summary":null,"downloadable_attachments":[{"id":82082588,"asset_id":73639762,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36353963,"first_name":"Mona","last_name":"Momeni","domain_name":"independent","page_name":"MonaMomeni","display_name":"Mona Momeni","profile_url":"https://independent.academia.edu/MonaMomeni?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=186234","nofollow":false},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_72578596" data-work_id="72578596" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72578596/Structure_and_composition_of_tubular_aggregates_of_skeletal_muscle_fibres">Structure and composition of tubular aggregates of skeletal muscle fibres</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Unusual regions of densely packed membranous tubules known as tubular aggregates (TAs) have been observed in skeletal muscle fibres of mammals under numerous pathological conditions but also in health. Their causality is unclear. It is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72578596" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Unusual regions of densely packed membranous tubules known as tubular aggregates (TAs) have been observed in skeletal muscle fibres of mammals under numerous pathological conditions but also in health. Their causality is unclear. It is neither known whether TAs are destructive and should be treated or whether they have a compensating function in an endangered muscle. In spite of many similarities, the histochemical, immunocytochemical and ultrastructural characteristics of tubular aggregates do vary. Histochemistry provided an overall characteristic of TAs as membranous inclusions with a variety of enzymatic activities. Immunocytochemical evidence revealed that tubular aggregates contain miscellaneous proteins and that derive from membranes of sarcoplasmic reticulum and mitochondria. No evidence for the presence of contractile and cytoskeletal proteins in TAs was found. Ultrastructurally, TAs are characterized as more or less densely packed aggregates of vesicular or tubular membran...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72578596" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d8f278447547dba08d4ab6a1f55a24d8" rel="nofollow" data-download="{"attachment_id":81452681,"asset_id":72578596,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81452681/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="68173233" href="https://independent.academia.edu/MNovotov%C3%A1">M. Novotová</a><script data-card-contents-for-user="68173233" type="text/json">{"id":68173233,"first_name":"M.","last_name":"Novotová","domain_name":"independent","page_name":"MNovotová","display_name":"M. Novotová","profile_url":"https://independent.academia.edu/MNovotov%C3%A1?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_72578596 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72578596"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72578596, container: ".js-paper-rank-work_72578596", }); });</script></li><li class="js-percentile-work_72578596 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 72578596; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_72578596"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_72578596 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="72578596"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 72578596; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=72578596]").text(description); $(".js-view-count-work_72578596").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72578596").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72578596"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="167" href="https://www.academia.edu/Documents/in/Physiology">Physiology</a>, <script data-card-contents-for-ri="167" type="text/json">{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4228" href="https://www.academia.edu/Documents/in/Skeletal_muscle_biology">Skeletal muscle biology</a>, <script data-card-contents-for-ri="4228" type="text/json">{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="15719" href="https://www.academia.edu/Documents/in/Mitochondria">Mitochondria</a>, <script data-card-contents-for-ri="15719" type="text/json">{"id":15719,"name":"Mitochondria","url":"https://www.academia.edu/Documents/in/Mitochondria?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72578596]'), work: {"id":72578596,"title":"Structure and composition of tubular aggregates of skeletal muscle fibres","created_at":"2022-02-28T02:03:37.953-08:00","url":"https://www.academia.edu/72578596/Structure_and_composition_of_tubular_aggregates_of_skeletal_muscle_fibres?f_ri=186234","dom_id":"work_72578596","summary":"Unusual regions of densely packed membranous tubules known as tubular aggregates (TAs) have been observed in skeletal muscle fibres of mammals under numerous pathological conditions but also in health. Their causality is unclear. It is neither known whether TAs are destructive and should be treated or whether they have a compensating function in an endangered muscle. In spite of many similarities, the histochemical, immunocytochemical and ultrastructural characteristics of tubular aggregates do vary. Histochemistry provided an overall characteristic of TAs as membranous inclusions with a variety of enzymatic activities. Immunocytochemical evidence revealed that tubular aggregates contain miscellaneous proteins and that derive from membranes of sarcoplasmic reticulum and mitochondria. No evidence for the presence of contractile and cytoskeletal proteins in TAs was found. Ultrastructurally, TAs are characterized as more or less densely packed aggregates of vesicular or tubular membran...","downloadable_attachments":[{"id":81452681,"asset_id":72578596,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":68173233,"first_name":"M.","last_name":"Novotová","domain_name":"independent","page_name":"MNovotová","display_name":"M. Novotová","profile_url":"https://independent.academia.edu/MNovotov%C3%A1?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":4228,"name":"Skeletal muscle biology","url":"https://www.academia.edu/Documents/in/Skeletal_muscle_biology?f_ri=186234","nofollow":false},{"id":15719,"name":"Mitochondria","url":"https://www.academia.edu/Documents/in/Mitochondria?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=186234"},{"id":172350,"name":"Microtubules","url":"https://www.academia.edu/Documents/in/Microtubules?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":357849,"name":"Skeletal Muscle","url":"https://www.academia.edu/Documents/in/Skeletal_Muscle?f_ri=186234"},{"id":4037511,"name":"Muscle fibers skeletal","url":"https://www.academia.edu/Documents/in/Muscle_fibers_skeletal?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_65769185" data-work_id="65769185" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/65769185/Effect_of_Khaini_a_form_of_smokeless_chewing_tobacco_on_pulmonary_functions">Effect of 'Khaini'--a form of smokeless chewing tobacco on pulmonary functions</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Tobacco use is a public health concern worldwide as well as in India. Tobacco consumption is mainly done in two forms: smoked tobacco and smokeless tobacco. The tobacco use without burning is referred to as smokeless tobacco (SLT) use.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_65769185" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Tobacco use is a public health concern worldwide as well as in India. Tobacco consumption is mainly done in two forms: smoked tobacco and smokeless tobacco. The tobacco use without burning is referred to as smokeless tobacco (SLT) use. SLT use has been increased rapidly throughout the world especially among adolescent boys and young men by considering it as safe alternative of smoking. Because of vigorous efforts toward increasing awareness of the adverse effects of tobacco, smoking has been declined and paradoxically the use of SLT has been greatly increased (1). ‘Khaini’, tobacco with slaked lime, is one of the widely used SLT in India (2). Cigarette smoking has extensive effects on respiratory function (3). Like cigarette the most important constituent of ‘khaini is tobacco. This study attempts to f ind out whether ‘khaini ’ causes any unfavorable effects for the lungs by using PFTs. In this study pulmonary function indices of ‘khaini‘sers were compared with those of nonusers con...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/65769185" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ae74e436055fe97b3af428203d3adef3" rel="nofollow" data-download="{"attachment_id":77222177,"asset_id":65769185,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77222177/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="8978905" href="https://independent.academia.edu/PurushottamPramanik">Purushottam Pramanik</a><script data-card-contents-for-user="8978905" type="text/json">{"id":8978905,"first_name":"Purushottam","last_name":"Pramanik","domain_name":"independent","page_name":"PurushottamPramanik","display_name":"Purushottam Pramanik","profile_url":"https://independent.academia.edu/PurushottamPramanik?f_ri=186234","photo":"https://0.academia-photos.com/8978905/2930588/3429530/s65_purushottam.pramanik.jpg"}</script></span></span></li><li class="js-paper-rank-work_65769185 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="65769185"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 65769185, container: ".js-paper-rank-work_65769185", }); 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Tobacco consumption is mainly done in two forms: smoked tobacco and smokeless tobacco. The tobacco use without burning is referred to as smokeless tobacco (SLT) use. SLT use has been increased rapidly throughout the world especially among adolescent boys and young men by considering it as safe alternative of smoking. Because of vigorous efforts toward increasing awareness of the adverse effects of tobacco, smoking has been declined and paradoxically the use of SLT has been greatly increased (1). ‘Khaini’, tobacco with slaked lime, is one of the widely used SLT in India (2). Cigarette smoking has extensive effects on respiratory function (3). Like cigarette the most important constituent of ‘khaini is tobacco. This study attempts to f ind out whether ‘khaini ’ causes any unfavorable effects for the lungs by using PFTs. 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Results from the national probabilistic survey ENSANUT 2006","created_at":"2021-12-18T21:47:08.214-08:00","url":"https://www.academia.edu/65052390/Anemia_and_iron_deficiency_prevalence_in_Mexican_adolescents_Results_from_the_national_probabilistic_survey_ENSANUT_2006?f_ri=186234","dom_id":"work_65052390","summary":null,"downloadable_attachments":[],"ordered_authors":[{"id":51824050,"first_name":"Vanessa De la Cruz","last_name":"Gongora","domain_name":"independent","page_name":"VanessaDelaCruzGongora","display_name":"Vanessa De la Cruz Gongora","profile_url":"https://independent.academia.edu/VanessaDelaCruzGongora?f_ri=186234","photo":"/images/s65_no_pic.png"},{"id":212560250,"first_name":"Elsa Berenice","last_name":"Gaona Pineda","domain_name":"independent","page_name":"ElsaBereniceGaonaPineda","display_name":"Elsa Berenice Gaona Pineda","profile_url":"https://independent.academia.edu/ElsaBereniceGaonaPineda?f_ri=186234","photo":"https://0.academia-photos.com/212560250/71645667/60094618/s65_elsa_berenice.gaona_pineda.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=186234","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58307073" data-work_id="58307073" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58307073/Development_of_pigment_dispersing_hormone_immunoreactive_neurons_in_the_American_lobster_homology_to_the_insect_circadian_pacemaker_system">Development of pigment-dispersing hormone-immunoreactive neurons in the American lobster: homology to the insect circadian pacemaker system?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58307073" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7fd4f0324a182387002c1a8b2d51fd99" rel="nofollow" data-download="{"attachment_id":72783001,"asset_id":58307073,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/72783001/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51812042" href="https://su-se.academia.edu/HDircksen">Heinrich Dircksen</a><script data-card-contents-for-user="51812042" type="text/json">{"id":51812042,"first_name":"Heinrich","last_name":"Dircksen","domain_name":"su-se","page_name":"HDircksen","display_name":"Heinrich Dircksen","profile_url":"https://su-se.academia.edu/HDircksen?f_ri=186234","photo":"https://0.academia-photos.com/51812042/33654408/29899552/s65_heinrich.dircksen.jpg"}</script></span></span></li><li class="js-paper-rank-work_58307073 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="58307073"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 58307073, container: ".js-paper-rank-work_58307073", }); 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Shoot cultures were cold-hardened at 5 degree C on MS medium... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_56294640" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A cryopreservation procedure using an aluminium cryo-plate was successfully developed using in vitro-grown Dalmatian chrysanthemum (Tanacetum cinerariifolium) shoot tips. Shoot cultures were cold-hardened at 5 degree C on MS medium containing 0.5 M sucrose over a period of 20 to 40 days. Shoot tips with basal plate (1.0-1.5 x 1.0 mm) were dissected from shoot cultures and precultured at 5 degree C for 2 days on MS medium containing 0.5 M sucrose. Precultured shoot tips were placed on aluminium cryo-plates (7 mm x 37 mm x 0.5 mm) with 10 wells (diameter 1.5 mm, depth 0.75 mm) and embedded in alginate gel. Osmoprotection was performed by immersing the cryo-plates for 30 or 60 min in 25 ml pipetting reservoirs filled with loading solution (2 M glycerol + 1.4 M sucrose). For dehydration, the loading solution was replaced with PVS 7M vitrification solution (30 percent glycerol, 19.5 percent ethylene glycol and 0.6 M sucrose in liquid MS basal medium), which was applied for 40 min. After ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/56294640" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4dd17b91925ccae3a3f58c05fae04c73" rel="nofollow" data-download="{"attachment_id":71751046,"asset_id":56294640,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71751046/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="51943208" href="https://independent.academia.edu/TariqRafique4">Tariq Rafique</a><script data-card-contents-for-user="51943208" type="text/json">{"id":51943208,"first_name":"Tariq","last_name":"Rafique","domain_name":"independent","page_name":"TariqRafique4","display_name":"Tariq Rafique","profile_url":"https://independent.academia.edu/TariqRafique4?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_56294640 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="56294640"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 56294640, container: ".js-paper-rank-work_56294640", }); 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Shoot cultures were cold-hardened at 5 degree C on MS medium containing 0.5 M sucrose over a period of 20 to 40 days. Shoot tips with basal plate (1.0-1.5 x 1.0 mm) were dissected from shoot cultures and precultured at 5 degree C for 2 days on MS medium containing 0.5 M sucrose. Precultured shoot tips were placed on aluminium cryo-plates (7 mm x 37 mm x 0.5 mm) with 10 wells (diameter 1.5 mm, depth 0.75 mm) and embedded in alginate gel. Osmoprotection was performed by immersing the cryo-plates for 30 or 60 min in 25 ml pipetting reservoirs filled with loading solution (2 M glycerol + 1.4 M sucrose). For dehydration, the loading solution was replaced with PVS 7M vitrification solution (30 percent glycerol, 19.5 percent ethylene glycol and 0.6 M sucrose in liquid MS basal medium), which was applied for 40 min. After ...","downloadable_attachments":[{"id":71751046,"asset_id":56294640,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":51943208,"first_name":"Tariq","last_name":"Rafique","domain_name":"independent","page_name":"TariqRafique4","display_name":"Tariq Rafique","profile_url":"https://independent.academia.edu/TariqRafique4?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":151,"name":"Cryobiology","url":"https://www.academia.edu/Documents/in/Cryobiology?f_ri=186234","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=186234","nofollow":false},{"id":19295,"name":"Cryopreservation","url":"https://www.academia.edu/Documents/in/Cryopreservation?f_ri=186234","nofollow":false},{"id":27497,"name":"Instrumentation","url":"https://www.academia.edu/Documents/in/Instrumentation?f_ri=186234","nofollow":false},{"id":55258,"name":"Aluminum","url":"https://www.academia.edu/Documents/in/Aluminum?f_ri=186234"},{"id":121939,"name":"Technique","url":"https://www.academia.edu/Documents/in/Technique?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":448182,"name":"Vitrification","url":"https://www.academia.edu/Documents/in/Vitrification?f_ri=186234"},{"id":2150526,"name":"Shoot","url":"https://www.academia.edu/Documents/in/Shoot?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_55383334" data-work_id="55383334" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/55383334/Regulation_of_secretion_of_PTHrP_by_Ca_2_sensing_receptor_in_human_astrocytes_astrocytomas_and_meningiomas">Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Parathyroid hormone-related protein (PTHrP) is the major mediator of the humoral hypercalcemia of malignancy and of malignant osteolysis associated with skeletal metastases of common epithelial cancers. PTHrP secretion is regulated by the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_55383334" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Parathyroid hormone-related protein (PTHrP) is the major mediator of the humoral hypercalcemia of malignancy and of malignant osteolysis associated with skeletal metastases of common epithelial cancers. PTHrP secretion is regulated by the extracellular calcium concentration ([Ca(2+)](o)) in several types of normal and malignant cells. Because the [Ca(2+)](o)-sensing receptor (CaR) is a key mediator of [Ca(2+)](o)-regulated hormone secretion [e.g., of parathyroid hormone (PTH) by parathyroid chief cells], we investigated the expression of the CaR and PTHrP in normal and neoplastic glial cells and studied the effects of [Ca(2+)](o) on PTHrP secretion. Our results show that primary embryonic human astrocytes (HPA) express CaR mRNA and protein as detected by RT-PCR and Western analysis, respectively. Furthermore, astrocytomas and meningiomas also express the CaR at similar levels as assessed by RT-PCR and Northern and Western blot analyses. HPA and astrocytomas express transcripts encod...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55383334" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a6b75f52fd82f218c0e1b843ba6c95fa" rel="nofollow" data-download="{"attachment_id":71278410,"asset_id":55383334,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/71278410/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42187918" href="https://istanbulbilim.academia.edu/CetinEvliyaoglu">Cetin Evliyaoglu</a><script data-card-contents-for-user="42187918" type="text/json">{"id":42187918,"first_name":"Cetin","last_name":"Evliyaoglu","domain_name":"istanbulbilim","page_name":"CetinEvliyaoglu","display_name":"Cetin Evliyaoglu","profile_url":"https://istanbulbilim.academia.edu/CetinEvliyaoglu?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_55383334 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="55383334"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 55383334, container: ".js-paper-rank-work_55383334", }); 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PTHrP secretion is regulated by the extracellular calcium concentration ([Ca(2+)](o)) in several types of normal and malignant cells. Because the [Ca(2+)](o)-sensing receptor (CaR) is a key mediator of [Ca(2+)](o)-regulated hormone secretion [e.g., of parathyroid hormone (PTH) by parathyroid chief cells], we investigated the expression of the CaR and PTHrP in normal and neoplastic glial cells and studied the effects of [Ca(2+)](o) on PTHrP secretion. Our results show that primary embryonic human astrocytes (HPA) express CaR mRNA and protein as detected by RT-PCR and Western analysis, respectively. Furthermore, astrocytomas and meningiomas also express the CaR at similar levels as assessed by RT-PCR and Northern and Western blot analyses. HPA and astrocytomas express transcripts encod...","downloadable_attachments":[{"id":71278410,"asset_id":55383334,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42187918,"first_name":"Cetin","last_name":"Evliyaoglu","domain_name":"istanbulbilim","page_name":"CetinEvliyaoglu","display_name":"Cetin Evliyaoglu","profile_url":"https://istanbulbilim.academia.edu/CetinEvliyaoglu?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology?f_ri=186234","nofollow":false},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry?f_ri=186234","nofollow":false},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":91499,"name":"Glioblastoma","url":"https://www.academia.edu/Documents/in/Glioblastoma?f_ri=186234"},{"id":151448,"name":"American","url":"https://www.academia.edu/Documents/in/American?f_ri=186234"},{"id":168200,"name":"Meningioma","url":"https://www.academia.edu/Documents/in/Meningioma?f_ri=186234"},{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":196442,"name":"Astrocytes","url":"https://www.academia.edu/Documents/in/Astrocytes?f_ri=186234"},{"id":332062,"name":"Parathyroid Hormone Related Protein","url":"https://www.academia.edu/Documents/in/Parathyroid_Hormone_Related_Protein?f_ri=186234"},{"id":859051,"name":"Astrocytoma","url":"https://www.academia.edu/Documents/in/Astrocytoma?f_ri=186234"},{"id":1425045,"name":"Brain Neoplasms","url":"https://www.academia.edu/Documents/in/Brain_Neoplasms?f_ri=186234"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology?f_ri=186234"},{"id":3067128,"name":"reverse transcriptase polymerase chain reaction","url":"https://www.academia.edu/Documents/in/reverse_transcriptase_polymerase_chain_reaction?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_49610797" data-work_id="49610797" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/49610797/Correlation_among_routine_semen_parameters_sperm_viabilty_and_malondialdehyde_levels_in_human_subjects_with_different_fertility_potential">Correlation among routine semen parameters, sperm viabilty and malondialdehyde levels in human subjects with different fertility potential</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Percentage of viable sperms has good potential to reflect male fertilizing potential. In the present study, an attempt was made to find out the percentage of viable sperms in normal and abnormal ejaculates and influence of reactive oxygen... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_49610797" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Percentage of viable sperms has good potential to reflect male fertilizing potential. In the present study, an attempt was made to find out the percentage of viable sperms in normal and abnormal ejaculates and influence of reactive oxygen species in affecting the viability of sperm. Malondialdehyde (MDA) in seminal plasma of normal and abnormal ejaculates was measured by Thiobarbituric Acid method and percentage of viable sperms was assessed by Eosin-Nigrosin staining. The results revealed that the abnormal semen samples have significantly lower number of viable spermatozoa (59.06 +/- 9.63% vs. 68.33 +/- 5.46%, P &lt; 0.05) and higher levels of MDA (2.53 +/- 0.66 vs. 1.66 +/- 0.37 nmol/ml, P &lt; 0.05) as compared to normal. A significant negative correlation was found between seminal MDA level and sperm viability. Based on the results obtained from the present study, we suggest that viability of sperm is an authentic parameter to assess male fertility potential and it can be affect...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/49610797" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="af989c90b2479676406274f2bfd02dda" rel="nofollow" data-download="{"attachment_id":67924596,"asset_id":49610797,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/67924596/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="145322156" href="https://independent.academia.edu/PiyaliDas34">Piyali Das</a><script data-card-contents-for-user="145322156" type="text/json">{"id":145322156,"first_name":"Piyali","last_name":"Das","domain_name":"independent","page_name":"PiyaliDas34","display_name":"Piyali Das","profile_url":"https://independent.academia.edu/PiyaliDas34?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_49610797 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="49610797"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 49610797, container: ".js-paper-rank-work_49610797", }); 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In the present study, an attempt was made to find out the percentage of viable sperms in normal and abnormal ejaculates and influence of reactive oxygen species in affecting the viability of sperm. Malondialdehyde (MDA) in seminal plasma of normal and abnormal ejaculates was measured by Thiobarbituric Acid method and percentage of viable sperms was assessed by Eosin-Nigrosin staining. The results revealed that the abnormal semen samples have significantly lower number of viable spermatozoa (59.06 +/- 9.63% vs. 68.33 +/- 5.46%, P \u0026lt; 0.05) and higher levels of MDA (2.53 +/- 0.66 vs. 1.66 +/- 0.37 nmol/ml, P \u0026lt; 0.05) as compared to normal. A significant negative correlation was found between seminal MDA level and sperm viability. Based on the results obtained from the present study, we suggest that viability of sperm is an authentic parameter to assess male fertility potential and it can be affect...","downloadable_attachments":[{"id":67924596,"asset_id":49610797,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":145322156,"first_name":"Piyali","last_name":"Das","domain_name":"independent","page_name":"PiyaliDas34","display_name":"Piyali Das","profile_url":"https://independent.academia.edu/PiyaliDas34?f_ri=186234","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":8954,"name":"Fertility","url":"https://www.academia.edu/Documents/in/Fertility?f_ri=186234","nofollow":false},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=186234","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=186234","nofollow":false},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=186234"},{"id":141898,"name":"Semen Analysis","url":"https://www.academia.edu/Documents/in/Semen_Analysis?f_ri=186234"},{"id":178928,"name":"Male Infertility","url":"https://www.academia.edu/Documents/in/Male_Infertility?f_ri=186234"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation?f_ri=186234"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=186234"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=186234"},{"id":862371,"name":"Spermatozoa","url":"https://www.academia.edu/Documents/in/Spermatozoa?f_ri=186234"},{"id":963536,"name":"Sperm Count","url":"https://www.academia.edu/Documents/in/Sperm_Count?f_ri=186234"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival?f_ri=186234"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=186234"},{"id":1446339,"name":"Malondialdehyde","url":"https://www.academia.edu/Documents/in/Malondialdehyde?f_ri=186234"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 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class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47310058/Long_term_evaluation_of_corneal_sub_basal_nerve_recovery_after_photorefractive_keratectomy_and_influence_of_pars_plana_vitrectomy">Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47310058" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li 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href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5525" href="https://www.academia.edu/Documents/in/Clinical_Neuroscience">Clinical Neuroscience</a><script data-card-contents-for-ri="5525" type="text/json">{"id":5525,"name":"Clinical Neuroscience","url":"https://www.academia.edu/Documents/in/Clinical_Neuroscience?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=47308480]'), work: {"id":47308480,"title":"Congenital myasthenic 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Analysis","url":"https://www.academia.edu/Documents/in/Genetic_Analysis?f_ri=186234"},{"id":995334,"name":"Neuromuscular Junction","url":"https://www.academia.edu/Documents/in/Neuromuscular_Junction?f_ri=186234"},{"id":2746952,"name":"cholinergic mechanisms","url":"https://www.academia.edu/Documents/in/cholinergic_mechanisms?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_44077757" data-work_id="44077757" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/44077757/Peripartum_cardiomyopathy_presenting_with_ventricular_tachycardia_a_rare_presentation">Peripartum cardiomyopathy presenting with ventricular tachycardia: a rare presentation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">A 25-year-old previously asymptomatic pregnant woman at 36 weeks&#39; gestation was noticed to have repetitive monomorphic ventricular tachycardia. A dilated left ventricle with moderately reduced systolic function was found on... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_44077757" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">A 25-year-old previously asymptomatic pregnant woman at 36 weeks&#39; gestation was noticed to have repetitive monomorphic ventricular tachycardia. A dilated left ventricle with moderately reduced systolic function was found on echocardiographic examination. This is a very rare presentation of peripartum cardiomyopathy (PPCMP) presenting with repetitive monomorphic ventricular tachycardia.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/44077757" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="483b995675087747d6e3c2f9c34e0458" rel="nofollow" data-download="{"attachment_id":64422043,"asset_id":44077757,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/64422043/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="170074956" href="https://independent.academia.edu/varunnarain2">varun narain</a><script data-card-contents-for-user="170074956" type="text/json">{"id":170074956,"first_name":"varun","last_name":"narain","domain_name":"independent","page_name":"varunnarain2","display_name":"varun narain","profile_url":"https://independent.academia.edu/varunnarain2?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_44077757 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="44077757"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 44077757, container: ".js-paper-rank-work_44077757", }); });</script></li><li class="js-percentile-work_44077757 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 44077757; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_44077757"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_44077757 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="44077757"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 44077757; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=44077757]").text(description); $(".js-view-count-work_44077757").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_44077757").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="44077757"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="186234" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a><script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=44077757]'), work: {"id":44077757,"title":"Peripartum cardiomyopathy presenting with ventricular tachycardia: a rare presentation","created_at":"2020-09-13T01:19:10.927-07:00","url":"https://www.academia.edu/44077757/Peripartum_cardiomyopathy_presenting_with_ventricular_tachycardia_a_rare_presentation?f_ri=186234","dom_id":"work_44077757","summary":"A 25-year-old previously asymptomatic pregnant woman at 36 weeks\u0026#39; gestation was noticed to have repetitive monomorphic ventricular tachycardia. 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href="https://www.academia.edu/Documents/in/Carbon_Dioxide">Carbon Dioxide</a>, <script data-card-contents-for-ri="4594" type="text/json">{"id":4594,"name":"Carbon Dioxide","url":"https://www.academia.edu/Documents/in/Carbon_Dioxide?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="86785" href="https://www.academia.edu/Documents/in/Applied_Ergonomics">Applied Ergonomics</a><script data-card-contents-for-ri="86785" type="text/json">{"id":86785,"name":"Applied Ergonomics","url":"https://www.academia.edu/Documents/in/Applied_Ergonomics?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6625106]'), work: {"id":6625106,"title":"Influence of inspiratory resistance on performance during graded exercise tests on a cycle 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Mechanics","url":"https://www.academia.edu/Documents/in/Respiratory_Mechanics?f_ri=186234"},{"id":2195595,"name":"Tidal volume","url":"https://www.academia.edu/Documents/in/Tidal_volume?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7676574" data-work_id="7676574" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7676574/134th_ENMC_International_Workshop_Outcome_Measures_and_Treatment_of_Spinal_Muscular_Atrophy11_13_February_2005Naarden_The_Netherlands">134th ENMC International Workshop: Outcome Measures and Treatment of Spinal Muscular Atrophy11–13 February 2005Naarden, The Netherlands</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item 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href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62692" href="https://www.academia.edu/Documents/in/Spinal_Muscular_Atrophy">Spinal Muscular Atrophy</a>, <script data-card-contents-for-ri="62692" type="text/json">{"id":62692,"name":"Spinal Muscular Atrophy","url":"https://www.academia.edu/Documents/in/Spinal_Muscular_Atrophy?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="99234" href="https://www.academia.edu/Documents/in/Animals">Animals</a><script data-card-contents-for-ri="99234" type="text/json">{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7676574]'), work: {"id":7676574,"title":"134th ENMC International Workshop: Outcome Measures and Treatment of Spinal Muscular Atrophy11–13 February 2005Naarden, The 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href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="111545" href="https://www.academia.edu/Documents/in/Male">Male</a>, <script data-card-contents-for-ri="111545" type="text/json">{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="186234" href="https://www.academia.edu/Documents/in/Medical_Physiology">Medical Physiology</a>, <script data-card-contents-for-ri="186234" type="text/json">{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology?f_ri=186234","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="218464" href="https://www.academia.edu/Documents/in/Dilated_cardiomyopathy">Dilated cardiomyopathy</a><script data-card-contents-for-ri="218464" type="text/json">{"id":218464,"name":"Dilated cardiomyopathy","url":"https://www.academia.edu/Documents/in/Dilated_cardiomyopathy?f_ri=186234","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26111941]'), work: {"id":26111941,"title":"Weaning failure from mechanical ventilation due to dilated cardiomyopathy: successful use of 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href="https://www.academia.edu/21458270/Clothing_surface_area_as_related_to_body_volume_and_clothing_microenvironment_volume">Clothing surface area as related to body volume and clothing microenvironment volume</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The evaluation of clothing surface area becomes important in analyses of heat exchange between the clothed body and its environment. The evidence accumulated in the studies of radiation area has led to the conclusion that the ratio of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21458270" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The evaluation of clothing surface area becomes important in analyses of heat exchange between the clothed body and its environment. The evidence accumulated in the studies of radiation area has led to the conclusion that the ratio of clothing surface area to body surface area (fcl) may be defined as a function of clothing insulation. However, the effects of clothing fit have been disregarded. Radiation area factors (Ar/AD) were derived from pictures of five subjects wearing four different helicopter pilot suits. While sitting on a seat suspended in the center of a box-shaped frame, photographs were taken of the subjects with a fish-eye lens at 90 equidistant points on the six sides of the frame. The derived Ar/AD of 0.7 +/- 0.18 for the unclothed subjects closely agreed with that reported by Fanger, while it scattered in a relatively wide range for a given suit. The present study proposes a new approach for predicting fcl as related to body volume and the clothing microenvironment ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21458270" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="138b31b913309544bdd3bbaea712739c" rel="nofollow" data-download="{"attachment_id":41888227,"asset_id":21458270,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41888227/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36435558" href="https://ijs.academia.edu/IgorMekjavic">Igor Mekjavic</a><script data-card-contents-for-user="36435558" type="text/json">{"id":36435558,"first_name":"Igor","last_name":"Mekjavic","domain_name":"ijs","page_name":"IgorMekjavic","display_name":"Igor Mekjavic","profile_url":"https://ijs.academia.edu/IgorMekjavic?f_ri=186234","photo":"https://0.academia-photos.com/36435558/12003878/13373575/s65_igor.mekjavic.jpg_oh_e14941d5bd25cef27ccd801485c4930f_oe_579218d5"}</script></span></span></li><li class="js-paper-rank-work_21458270 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21458270"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21458270, container: ".js-paper-rank-work_21458270", }); 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The evidence accumulated in the studies of radiation area has led to the conclusion that the ratio of clothing surface area to body surface area (fcl) may be defined as a function of clothing insulation. However, the effects of clothing fit have been disregarded. Radiation area factors (Ar/AD) were derived from pictures of five subjects wearing four different helicopter pilot suits. While sitting on a seat suspended in the center of a box-shaped frame, photographs were taken of the subjects with a fish-eye lens at 90 equidistant points on the six sides of the frame. The derived Ar/AD of 0.7 +/- 0.18 for the unclothed subjects closely agreed with that reported by Fanger, while it scattered in a relatively wide range for a given suit. 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Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=186234"},{"id":1823382,"name":"Intracellular Calcium","url":"https://www.academia.edu/Documents/in/Intracellular_Calcium?f_ri=186234"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16668003 coauthored" data-work_id="16668003" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16668003/Expression_of_the_voltage_gated_potassium_channel_KCNQ1_in_mammalian_taste_bud_cells_and_the_effect_of_its_null_mutation_on_taste_preferences">Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Vertebrate taste buds undergo continual cell turnover. To understand how the gustatory progenitor cells in the stratified lingual epithelium migrate and differentiate into different types of mature taste cells, we sought to identify genes... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16668003" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Vertebrate taste buds undergo continual cell turnover. To understand how the gustatory progenitor cells in the stratified lingual epithelium migrate and differentiate into different types of mature taste cells, we sought to identify genes that were selectively expressed in taste cells at different maturation stages. Here we report the expression of the voltage-gated potassium channel KCNQ1 in mammalian taste buds of mouse, rat, and human. Immunohistochemistry and nuclear staining showed that nearly all rodent and human taste cells express this channel. Double immunostaining with antibodies against type II and III taste cell markers validated the presence of KCNQ1 in these two types of cells. Co-localization studies with cytokeratin 14 indicated that KCNQ1 is also expressed in type IV basal precursor cells. Null mutation of the kcnq1 gene in mouse, however, did not alter the gross structure of taste buds or the expression of taste signaling molecules. Behavioral assays showed that the mutant mice display reduced preference to some umami substances, but not to any other taste compounds tested. Gustatory nerve recordings, however, were unable to detect any significant change in the integrated nerve responses of the mutant mice to umami stimuli. These results suggest that although it is expressed in nearly all taste bud cells, the function of KCNQ1 is not required for gross taste bud development or peripheral taste transduction pathways, and the reduced preference of kcnq1-null mice in the behavioral assays may be attributable to the deficiency in the central nervous system or other organs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16668003" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fd4fa056743c26b40bdb6e67b557f329" rel="nofollow" data-download="{"attachment_id":42418940,"asset_id":16668003,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42418940/download_file?st=MTczMjM4MDA3Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36032973" href="https://independent.academia.edu/RobertMargolskee">Robert Margolskee</a><script data-card-contents-for-user="36032973" type="text/json">{"id":36032973,"first_name":"Robert","last_name":"Margolskee","domain_name":"independent","page_name":"RobertMargolskee","display_name":"Robert Margolskee","profile_url":"https://independent.academia.edu/RobertMargolskee?f_ri=186234","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16668003">+1</span><div class="hidden js-additional-users-16668003"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://monell.academia.edu/AlexanderBachmanov">Alexander A Bachmanov</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16668003'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16668003').html(); 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To understand how the gustatory progenitor cells in the stratified lingual epithelium migrate and differentiate into different types of mature taste cells, we sought to identify genes that were selectively expressed in taste cells at different maturation stages. Here we report the expression of the voltage-gated potassium channel KCNQ1 in mammalian taste buds of mouse, rat, and human. Immunohistochemistry and nuclear staining showed that nearly all rodent and human taste cells express this channel. Double immunostaining with antibodies against type II and III taste cell markers validated the presence of KCNQ1 in these two types of cells. Co-localization studies with cytokeratin 14 indicated that KCNQ1 is also expressed in type IV basal precursor cells. Null mutation of the kcnq1 gene in mouse, however, did not alter the gross structure of taste buds or the expression of taste signaling molecules. Behavioral assays showed that the mutant mice display reduced preference to some umami substances, but not to any other taste compounds tested. Gustatory nerve recordings, however, were unable to detect any significant change in the integrated nerve responses of the mutant mice to umami stimuli. These results suggest that although it is expressed in nearly all taste bud cells, the function of KCNQ1 is not required for gross taste bud development or peripheral taste transduction pathways, and the reduced preference of kcnq1-null mice in the behavioral assays may be attributable to the deficiency in the central nervous system or other organs.","downloadable_attachments":[{"id":42418940,"asset_id":16668003,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36032973,"first_name":"Robert","last_name":"Margolskee","domain_name":"independent","page_name":"RobertMargolskee","display_name":"Robert Margolskee","profile_url":"https://independent.academia.edu/RobertMargolskee?f_ri=186234","photo":"/images/s65_no_pic.png"},{"id":35878990,"first_name":"Alexander","last_name":"Bachmanov","domain_name":"monell","page_name":"AlexanderBachmanov","display_name":"Alexander A 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data-unfollow-ri-id="1239755">Following</a></div></li></ul></div></div></div></div></div></div><script>// MIT License // Copyright © 2011 Sebastian Tschan, https://blueimp.net // Permission is hereby granted, free of charge, to any person obtaining a copy of // this software and associated documentation files (the "Software"), to deal in // the Software without restriction, including without limitation the rights to // use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of // the Software, and to permit persons to whom the Software is furnished to do so, // subject to the following conditions: // The above copyright notice and this permission notice shall be included in all // copies or substantial portions of the Software. // THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR // IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS // FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. 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