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href="https://www.academia.edu/101350693/Synergistic_Cooperation_between_Hypoxia_and_Transforming_Growth_Factor_%CE%B2_Pathways_on_Human_Vascular_Endothelial_Growth_Factor_Gene_Expression"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="53207412" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53207412/Induction_of_Hypoxia_inducible_Factor_1_Gene_Expression_by_Vascular_Endothelial_Growth_Factor">Induction of Hypoxia-inducible Factor 1 Gene Expression by Vascular Endothelial Growth Factor</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="67585714" 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href="https://www.academia.edu/53207412/Induction_of_Hypoxia_inducible_Factor_1_Gene_Expression_by_Vascular_Endothelial_Growth_Factor"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="56655698" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56655698/Oncogenic_transformation_and_hypoxia_synergistically_act_to_modulate_vascular_endothelial_growth_factor_expression">Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="66588090" href="https://independent.academia.edu/KeithLaderoute">Keith Laderoute</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1996</p><p class="ds-related-work--abstract ds2-5-body-sm">Hypoxia can select for cells that have lost their apoptotic potential, thereby making them resistant to adverse conditions. However, long-term survival of transformed cells which have diminished apoptotic sensitivity when exposed to low oxygen conditions would require the activation of their angiogenic program to compensate for an insufficient oxygen supply. In this report, we show that the activity (of oncogenic Ha-ras, either constitutively or transiently, enhances the induction of the angiogenic mitogen, vascular endothelial growth factor (VEGF), by hypoxia. Analysis of the 5&#39; flanking region of the VEGF promoter indicates that a HIF-1-like sequence is to promote a 15-fold increase in reporter gene activity in Ha-ras-transformed cells when exposed to hypoxia, whereas mutations in the same site totally inhibited VEGF induction. Under low oxygen conditions, VEGF induction is inhibited in cells expressing a mutant inhibitory allele of Ha-ras (RasN17), indicating a direct role fo...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression","attachmentId":71934702,"attachmentType":"pdf","work_url":"https://www.academia.edu/56655698/Oncogenic_transformation_and_hypoxia_synergistically_act_to_modulate_vascular_endothelial_growth_factor_expression","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56655698/Oncogenic_transformation_and_hypoxia_synergistically_act_to_modulate_vascular_endothelial_growth_factor_expression"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="52798346" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/52798346/Synergistic_Cooperation_between_Hypoxia_and_Transforming_Growth_Factor_beta_Pathways_on_Human_Vascular_Endothelial_Growth_Factor_Gene_Expression">Synergistic Cooperation between Hypoxia and Transforming Growth Factor-beta Pathways on Human Vascular Endothelial Growth Factor Gene Expression</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33247403" href="https://csic.academia.edu/CarmeloBernabeu">Carmelo Bernabeu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Synergistic Cooperation between Hypoxia and Transforming Growth Factor-beta Pathways on Human Vascular Endothelial Growth Factor Gene Expression","attachmentId":69889584,"attachmentType":"pdf","work_url":"https://www.academia.edu/52798346/Synergistic_Cooperation_between_Hypoxia_and_Transforming_Growth_Factor_beta_Pathways_on_Human_Vascular_Endothelial_Growth_Factor_Gene_Expression","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/52798346/Synergistic_Cooperation_between_Hypoxia_and_Transforming_Growth_Factor_beta_Pathways_on_Human_Vascular_Endothelial_Growth_Factor_Gene_Expression"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":71245007,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":71245007,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_71245007" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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data-collection-position="5" data-entity-id="16515859" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/16515859/The_hypoxia_inducible_factor_1_NOR_1_axis_regulates_the_survival_response_of_endothelial_cells_to_hypoxia">The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35758793" href="https://csic.academia.edu/JordiRius">Jordi Rius</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to 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translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="58118896" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/58118896/Regulation_of_gene_expression_by_hypoxia">Regulation of gene expression by hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51182548" href="https://independent.academia.edu/SoniaRocha12">Sonia Rocha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical Journal, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Regulation of gene expression by 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